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https://www.readbyqxmd.com/read/29909019/efficacy-of-ustekinumab-in-inducing-endoscopic-healing-in-patients-with-crohn-s-disease
#1
Paul Rutgeerts, Christopher Gasink, Daphne Chan, Yinghua Lang, Paul Pollack, Jean-Frederic Colombel, Douglas C Wolf, Douglas Jacobstein, Jewel Johanns, Philippe Szapary, Omoniyi J Adedokun, Brian G Feagan, William J Sandborn
BACKGROUND & AIMS: We evaluated the ability of ustekinumab, a monoclonal antibody against the p40 subunit of interleukins 12 and 23, to induce endoscopic healing in patients with moderate to severe Crohn's disease (CD). METHODS: We performed an endoscopy sub-study of 334 patients with moderate to severe CD participating in 3 randomized, controlled, phase 3 studies to determine the safety and efficacy of ustekinumab induction and maintenance therapy. All patients underwent colonoscopy at baseline and week 8 of the induction studies and at week 44 of the maintenance study; all colonoscopies were assessed by a blinded central reader...
June 14, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29908340/ureterolysis-for-laparoscopic-hysterectomy
#2
Haider Jan, Vishalli Ghai
STUDY OBJECTIVE: To demonstrate techniques of ureterolysis during complex laparoscopic hysterectomy. DESIGN: Technical video demonstrating different approaches to ureterolysis for complex benign pathology during laparoscopic hysterectomy. (Canadian Task force classification level III) SETTING: Benign gynaecology department at a University Hospital. INTERVENTION: We perform ureterolysis during laparoscopic hysterectomy for benign pathology...
June 13, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29908311/longitudinal-study-of-neonatal-brain-tissue-volumes-in-preterm-infants-and-their-ability-to-predict-neurodevelopmental-outcome
#3
REVIEW
L Gui, S Loukas, F Lazeyras, P S Hüppi, D E Meskaldji, C Borradori Tolsa
Premature birth has been associated with poor neurodevelopmental outcomes. However, the relation between such outcomes and brain growth in the neonatal period has not yet been fully elucidated. This study investigates longitudinal brain development between birth and term-equivalent age (TEA) by quantitative imaging in a cohort of premature infants born between 26 and 36 weeks gestational age (GA), to provide insight into the relation of brain growth with later neurodevelopmental outcomes. Longitudinal T2-weighted magnetic resonance images (MRI) of 84 prematurely born infants acquired shortly after birth and TEA were automatically segmented into cortical gray matter (CGM), unmyelinated white matter (UWM), subcortical gray matter (SGM), cerebellum (CB) and cerebrospinal fluid (CSF)...
June 13, 2018: NeuroImage
https://www.readbyqxmd.com/read/29907347/ophthalmological-changes-of-the-posterior-segment-in-patients-with-testicular-cancer-in-a-mixed-race-population-of-the-general-hospital-of-mexico
#4
D M Barba-Navarrete, D Moreno-Páramo, V E Corona-Montes, L E Tapia-López, E Montiel-Delgado
INTRODUCTION: The curing of a testicular tumour is currently feasible in more than 95% of patients, and in 80% of those with metastases. Until now, there has been no study or series of cases that describe the ocular changes of the posterior segment associated with testicular cancer. OBJECTIVE: To evaluate patients with a diagnosis of testicular cancer in order to determine the presence of changes in the posterior segment and the relationship to the stage. MATERIAL AND METHOD: An observational, cross-sectional, and descriptive study was conducted on 21 male patients (42 eyes) with a diagnosis of testicular cancer...
June 12, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29906667/the-high-cost-of-critical-care-unit-over-utilization-for-patients-with-nste-acs
#5
Sean van Diepen, Dat T Tran, Justin A Ezekowitz, David A Zygun, Jason N Katz, Renato D Lopes, L Kristin Newby, Finlay A McAlister, Padma Kaul
BACKGROUND: There is substantial variability among hospitals in critical care unit (CCU) utilization for patients admitted with non-ST-Segment Elevation Acute Coronary Syndromes (NSTE ACS). We estimated the potential cost saving if all hospitals adopted low CCU utilization practices for patients with NSTE ACS. METHODS: National hospital claims data were used to identify all patients with a primary diagnosis of NSTE ACS initially admitted to an acute care hospital between 2007 and 2013...
May 19, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29902824/sporadic-schwannomatosis-a-systematic-review-following-the-2005-consensus-statement
#6
Gregoire Chick, Jan Victor, Thibault Poujade, Nadine Hollevoet
AIMS:  To identify the frequency of reports of sporadic schwannomatosis, the types of patients affected, and the nerves affected. PATIENTS AND METHODS:  We identified all case reports and case series that reported on patients with sporadic schwannomatosis according to established criteria. RESULTS:  The initial search yielded 1,597 studies, of which 15 were included. A total of 38 of 55 individuals met the inclusion criteria. The mean age of the patients was 48 years; 41% were male...
June 14, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29899750/quantitative-trait-locus-mapping-and-candidate-gene-analysis-for-verticillium-wilt-resistance-using-gossypium-barbadense-chromosomal-segment-introgressed-line
#7
Jun Zhao, Jianguang Liu, Jianwen Xu, Liang Zhao, Qiaojuan Wu, Songhua Xiao
Verticillium wilt (VW) is a soil-borne fungal disease that is caused by Verticillium dahliae Kleb and seriously damages cotton production annually in China. To date, many efforts have been made to improve the resistance of upland cotton against VW, but little progress has been achieved because of a lack of resistant upland cotton to VW. G. barbadense is known to carry high resistance to VW; however, it is difficult to transfer the resistance trait from G. barbadense to upland cotton because of linkage drag and distortion in the interspecific hybrid...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29897894/the-views-of-the-general-public-on-prioritising-vaccination-programmes-against-childhood-diseases-a-qualitative-study
#8
Gemma Lasseter, Hareth Al-Janabi, Caroline L Trotter, Fran E Carroll, Hannah Christensen
BACKGROUND: Decisions regarding which vaccines are funded in the United Kingdom (UK) are increasingly informed by cost-effectiveness analyses. Such analyses use Quality Adjusted Life Years (QALYs) as a measure of effectiveness and assume that QALYs are equal regardless of where and in whom they occur in the population. However, there is increasing debate about whether this QALY approach is appropriate and whether societal preferences for childhood vaccinations should be used to help inform childhood immunisation policy...
2018: PloS One
https://www.readbyqxmd.com/read/29896246/automatic-tube-potential-selection-with-tube-current-modulation-in-coronary-ct-angiography-can-it-achieve-consistent-image-quality-among-various-individuals
#9
Xiao-Ping Wang, Xiao-Mei Zhu, Yin-Su Zhu, Wang-Yan Liu, Xiao-Han Yang, Wei-Wei Huang, Yi Xu, Li-Jun Tang
The present study included a total of 111 consecutive patients who had undergone coronary computed tomography (CT) angiography, using a first-generation dual-source CT with automatic tube potential selection and tube current modulation. Body weight (BW) and body mass index (BMI) were recorded prior to CT examinations. Image noise and attenuation of the proximal ascending aorta (AA) and descending aorta (DA) at the middle level of the left ventricle were measured. Correlations between BW, BMI and objective image quality were evaluated using linear regression...
July 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29895484/coping-and-cardiac-troponin-t-a-risk-for-hypertension-and-sub-clinical-ecg-left-ventricular-hypertrophy-the-sabpa-study
#10
Catharina Elizabeth Myburgh, Leoné Malan, Annemarie Wentzel, Jacobus De Wet Scheepers, Nicolaas Theodor Malan
BACKGROUND: Defensive coping (DefS) was associated with cardiovascular disease (CVD) susceptibility in Blacks. Whether coping strategies will associate with sub-clinical left ventricular hypertrophy (electrocardiographic-left ventricular hypertrophy [ECG-LVH] or Cornell product), cardiomyocyte injury and blood pressure (BP), is unclear. Therefore, we assessed relationships between ECG-LVH, cardiac troponin T (cTnT) and 24-hour BP in bi-ethnic groups when habitually utilising a certain coping style, and these groups when having a stress-related cTnT cut-point of 4...
May 31, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29893358/sex-related-differences-in-short-and-long-term-outcome-among-young-and-middle-aged-patients-for-st-segment-elevation-myocardial-infarction-underwent-percutaneous-coronary-intervention
#11
Wen-Xia Fu, Tie-Nan Zhou, Xiao-Zeng Wang, Lei Zhang, Quan-Min Jing, Ya-Ling Han
Background: Females with ST-segment elevation myocardial infarction (STEMI) have higher in-hospital and short-term mortality rates compared with males in China, suggesting that a sex disparity exists. The age of onset of STEMI is ahead of time and tends to be younger. However, there are relatively little data on the significance of sex on prognosis for long-term outcomes for adult patients with STEMI after percutaneous coronary intervention (PCI) in China. This study sought to analyze the sex differences in 30-day, 1-year, and long-term net adverse clinical events (NACEs) in Chinese adult patients with STEMI after PCI...
June 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29892844/fine-mapping-and-candidate-gene-analysis-of-the-quantitative-trait-locus-gw8-1-associated-with-grain-length-in-rice
#12
Yun-Joo Kang, Kyu-Chan Shim, Hyun-Sook Lee, Yun-A Jeon, Sun-Ha Kim, Ju-Won Kang, Yeo-Tae Yun, In-Kyu Park, Sang-Nag Ahn
A quantitative trait locus (QTL) gw8.1 was detected in the population derived from a cross between the elite japonica cultivar, 'Hwaseong' and Oryza rufipogon (IRGC 105491). Near isogenic lines (NILs) harboring the O. rufipogon segment on chromosome 8 showed increased grain length and weight compared to those of the recurrent parent, Hwaseong. This QTL was mapped to a 175.3-kb region containing 28 genes, of which four were considered as candidates based on the presence of mutations in their coding regions and as per the RNA expression pattern during the inflorescence stage...
April 2018: Genes & Genomics
https://www.readbyqxmd.com/read/29892597/evidence-for-a-cyanine-link-between-propargylamine-drugs-and-monoamine-oxidase-clarifies-the-inactivation-mechanism
#13
Alen Albreht, Irena Vovk, Janez Mavri, Jose Marco-Contelles, Rona R Ramsay
Successful propargylamine drugs such as deprenyl inactivate monoamine oxidase (MAO), a target in multi-faceted approaches to prevent neurodegeneration in the aging population, but the chemical structure and mechanism of the irreversible inhibition are still debated. We characterized the covalent cyanine structure linking the multi-target propargylamine inhibitor ASS234 and the flavin adenine dinucleotide in MAO-A using a combination of ultra-high performance liquid chromatography, spectroscopy, mass spectrometry, and computational methods...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29891696/-staphylococcus-aureus-targets-the-purine-salvage-pathway-to-kill-phagocytes
#14
Volker Winstel, Dominique Missiakas, Olaf Schneewind
Staphylococcus aureus colonizes large segments of the human population and causes invasive infections due to its ability to escape phagocytic clearance. During infection, staphylococcal nuclease and adenosine synthase A convert neutrophil extracellular traps to deoxyadenosine (dAdo), which kills phagocytes. The mechanism whereby staphylococcal dAdo intoxicates phagocytes is not known. Here we used CRISPR-Cas9 mutagenesis to show that phagocyte intoxication involves uptake of dAdo via the human equilibrative nucleoside transporter 1, dAdo conversion to dAMP by deoxycytidine kinase and adenosine kinase, and signaling via subsequent dATP formation to activate caspase-3-induced cell death...
June 11, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29891037/clinical-characteristics-and-outcomes-in-young-patients-with-st-segment-elevation-myocardial-infarction-after-primary-percutaneous-coronary-intervention
#15
Ming Gao, Waiou Zhao, Zhiguo Zhang, Ling Qin, Weihua Zhang, Yang Zheng
BACKGROUND: There are few published studies of ST-segment elevation myocardial infarction (STEMI) in younger individuals. The differences between these "younger" and "older" individuals may not be fully appreciated by clinicians. The aim of this study was to determine the reasons for the earlier presentation and help to identify strategies for prevention of recurrent myocardial infarction (MI) in younger patients. METHODS: The study population was a cohort of 2,419 consecutive STEMI patients who were treated with primary percutaneous coronary intervention...
June 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29890459/improvise-adapt-and-overcome-challenges-in-management-of-pediatric-congenital-atlantoaxial-dislocation
#16
Pravin Salunke, Madhivanan Karthigeyan, Sushanta K Sahoo, Narasimhaiah Sunil
OBJECTIVE: Congenital atlanto-axial dislocation (CAAD) often manifests in younger age group. Softer bones, deformed joints and the concern of fusing multiple segments in growing age set apart this subset of patients from adults. Objectives of this manuscript are to discuss the challenges faced and subsequent solutions during multiplanar realignment and fusion (short segment) of C1-2 joints through a direct posterior approach in pediatric CAAD. PATIENTS & METHODS: 56 pediatric patients with CAAD were operated through a direct posterior approach in the last 4 years...
June 5, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29890155/insecticide-susceptibility-status-of-phlebotomus-argentipes-and-polymorphisms-in-voltage-gated-sodium-channel-vgsc-gene-in-kala-azar-endemic-areas-of-west-bengal-india
#17
Ashif Ali Sardar, Pabitra Saha, Moytrey Chatterjee, Dilip Kumar Bera, Prasanta Biswas, Dipankar Maji, Subhasish Kamal Guha, Nandita Basu, Ardhendu Kumar Maji
Rational use of insecticides, as advocated by World Health Organisation, plays a crucial role for vector control in eliminating visceral leishmaniasis from endemic countries. Emergence and spread of resistance among vector sand flies is of increasing concern for achieving these goals. Information on insecticide susceptibility status of sand fly populations and potential association between the former and polymorphisms in the insecticide target genes is important for formulating proper vector control measures...
June 8, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29889268/is-the-red-wolf-a-listable-unit-under-the-us-endangered-species-act
#18
Robin S Waples, Roland Kays, Richard J Fredrickson, Krishna Pacifici, L Scott Mills
Defining units that can be afforded legal protection is a crucial, albeit challenging, step in conservation planning. As we illustrate with a case study of the red wolf (Canis rufus) from the southeastern United States, this step is especially complex when the evolutionary history of the focal taxon is uncertain. The US Endangered Species Act (ESA) allows listing of species, subspecies, or Distinct Population Segments (DPSs) of vertebrates. Red wolves were listed as an endangered species in 1973, and their status remains precarious...
June 8, 2018: Journal of Heredity
https://www.readbyqxmd.com/read/29887538/circulating-sulfatide-a-novel-biomarker-for-st-segment-elevation-myocardial-infarction
#19
Gang Li, Rui Hu, Yifang Guo, Lili He, Qingjuan Zuo, Yan Wang
AIMS: ST-segment elevation myocardial infarction (STEMI) is an acute inflammatory and thrombotic disease due to coronary artery atherosclerotic lesions. Studies have established the correlation of serum sulfatides with inflammation, thrombogenesis, and atherosclerosis. We observed that serum sulfatides level significantly increased in STEMI patients. In this study, we try to identify the relationship of serum sulfatides level on clinical outcomes of patients in STEMI. METHODS: Serum sulfatides level was monitored in 370 inpatients within 24 h of STEMI onset...
June 9, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29886775/acute-myocardial-infarction-experience-among-mexican-american-women
#20
John R Bowles, Marylyn M McEwen, Anne G Rosenfeld
INTRODUCTION: Health disparities in cardiovascular disease risk factors affect a burgeoning segment of the U.S. population-Mexican American (MA) women. MAs experience disparities in the prevalence of heart disease risk factors. However, there are no studies describing acute myocardial infarction (AMI) symptoms unique to this Hispanic subgroup. The aim of the study was to describe MA women's AMI symptom experience. METHODS: A qualitative descriptive design guided the study...
January 1, 2018: Hispanic Health Care International: the Official Journal of the National Association of Hispanic Nurses
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