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https://www.readbyqxmd.com/read/28432954/fully-automatic-left-ventricular-segmentation-from-long-axis-cardiac-cine-mr-scans
#1
Rahil Shahzad, Qian Tao, Oleh Dzyubachyk, Marius Staring, Boudewijn P F Lelieveldt, Rob J van der Geest
With an increasing number of large-scale population-based cardiac magnetic resonance (CMR) imaging studies being conducted nowadays, there comes the mammoth task of image annotation and image analysis. Such population-based studies would greatly benefit from automated pipelines, with an efficient CMR image analysis workflow. The purpose of this work is to investigate the feasibility of using a fully-automatic pipeline to segment the left ventricular endocardium and epicardium simultaneously on two orthogonal (vertical and horizontal) long-axis cardiac cine MRI scans...
April 13, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28432747/whole-body-adipose-tissue-and-lean-muscle-volumes-and-their-distribution-across-gender-and-age-mr-derived-normative-values-in-a-normal-weight-swiss-population
#2
Erika J Ulbrich, Daniel Nanz, Olof Dahlqvist Leinhard, Magda Marcon, Michael A Fischer
PURPOSE: To determine age- and gender-dependent whole-body adipose tissue and muscle volumes in healthy Swiss volunteers in Dixon MRI in comparison with anthropometric and bioelectrical impedance (BIA) measurements. METHODS: Fat-water-separated whole-body 3 Tesla MRI of 80 healthy volunteers (ages 20 to 62 years) with a body mass index (BMI) of 17.5 to 26.2 kg/m(2) (10 men, 10 women per decade). Age and gender-dependent volumes of total adipose tissue (TAT), visceral adipose tissue (VAT), total abdominal subcutaneous adipose tissue (ASAT) and total abdominal adipose tissue (TAAT), and the total lean muscle tissue (TLMT) normalized for body height were determined by semi-automatic segmentation, and correlated with anthropometric and BIA measurements as well as lifestyle parameters...
April 22, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28432671/investigation-of-the-physical-effects-of-respiratory-motion-compensation-in-a-large-population-of-patients-undergoing-tc-99m-cardiac-perfusion-spect-ct-stress-imaging
#3
P Hendrik Pretorius, Karen L Johnson, Seth T Dahlberg, Michael A King
BACKGROUND: Respiratory motion can deteriorate image fidelity in cardiac perfusion SPECT. We determined the extent of respiratory motion, assessed its impact on image fidelity, and investigated the existence of gender differences, thereby examining the influence of respiratory motion in a large population of patients. METHODS: One thousand one hundred and three SPECT/CT patients underwent visual tracking of markers on their anterior surface during stress acquisition to track respiratory motion...
April 21, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28431003/intracoronary-autologous-bone-marrow-cell-transfer-after-myocardial-infarction-the-boost-2-randomised-placebo-controlled-clinical-trial
#4
Kai C Wollert, Gerd P Meyer, Jochen Müller-Ehmsen, Carsten Tschöpe, Vernon Bonarjee, Alf Inge Larsen, Andreas E May, Klaus Empen, Emmanuel Chorianopoulos, Ulrich Tebbe, Johannes Waltenberger, Heiko Mahrholdt, Benedikta Ritter, Jens Pirr, Dieter Fischer, Mortimer Korf-Klingebiel, Lubomir Arseniev, Hans-Gert Heuft, Jan E Brinchmann, Diethelm Messinger, Bernd Hertenstein, Arnold Ganser, Hugo A Katus, Stephan B Felix, Meinrad P Gawaz, Kenneth Dickstein, Heinz-Peter Schultheiss, Dennis Ladage, Simon Greulich, Johann Bauersachs
Aims: Intracoronary infusion of autologous nucleated bone marrow cells (BMCs) enhanced the recovery of left ventricular ejection fraction (LVEF) after ST-segment elevation myocardial infarction (STEMI) in the randomised-controlled, open-label BOOST trial. We reassessed the therapeutic potential of nucleated BMCs in the randomised placebo-controlled, double-blind BOOST-2 trial conducted in 10 centres in Germany and Norway. Methods and results: Using a multiple arm design, we investigated the dose-response relationship and explored whether γ-irradiation which eliminates the clonogenic potential of stem and progenitor cells has an impact on BMC efficacy...
April 19, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28428741/assessing-auditory-processing-deficits-in-tinnitus-and-hearing-impaired-patients-with-the-auditory-behavior-questionnaire
#5
Isabel Diges, Francisco Simón, Pedro Cobo
Background and Purpose: Auditory processing disorders (APD), tinnitus and hearing loss (HL) are typical issues reported by patients in audiologic clinics. These auditory impairments can be concomitant or mutually excluding. APD are not necessarily accompanied by significant HL, whereas many adults exhibit peripheral HL and typical cognitive deficits often associated with APD. Since HL, tinnitus and APD affects to several parts of the ascending auditory pathway from the periphery to the auditory cortex, there could be some interrelationship between them...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28428550/structure-based-dynamic-arrays-in-regulatory-domains-of-sodium-calcium-exchanger-ncx-isoforms
#6
Moshe Giladi, Su Youn Lee, Yarden Ariely, Yotam Teldan, Rotem Granit, Roi Strulovich, Yoni Haitin, Ka Young Chung, Daniel Khananshvili
Mammalian Na(+)/Ca(2+) exchangers, NCX1 and NCX3, generate splice variants, whereas NCX2 does not. The CBD1 and CBD2 domains form a regulatory tandem (CBD12), where Ca(2+) binding to CBD1 activates and Ca(2+) binding to CBD2 (bearing the splicing segment) alleviates the Na(+)-induced inactivation. Here, the NCX2-CBD12, NCX3-CBD12-B, and NCX3-CBD12-AC proteins were analyzed by small-angle X-ray scattering (SAXS) and hydrogen-deuterium exchange mass-spectrometry (HDX-MS) to resolve regulatory variances in the NCX2 and NCX3 variants...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28424763/airway-problems-in-neonates-a-review-of-the-current-investigation-and-management-strategies
#7
REVIEW
Quen Mok
Airway problems in the neonatal population are often life threatening and raise challenging issues in diagnosis and management. The airway problems can result from congenital or acquired lesions and can be broadly classified into those causing obstruction or those due to an abnormal "communication" in the airway. Many different investigations are now available to identify the diagnosis and quantify the severity of the problem, and these tests can be simple or invasive. Bronchography and bronchoscopy are essential to determine the extent and severity of the airway problem and to plan treatment strategy...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28422981/qtl-analysis-and-dissection-of-panicle-components-in-rice-using-advanced-backcross-populations-derived-from-oryza-sativa-cultivars-hr1128-and-nipponbare
#8
Zhizhong Sun, Xiaoling Yin, Jia Ding, Dong Yu, Miao Hu, Xuewu Sun, Yanning Tan, Xiabing Sheng, Ling Liu, Yi Mo, Ning Ouyang, Beibei Jiang, Guilong Yuan, Meijuan Duan, Dingyang Yuan, Jun Fang
Panicle traits are among the most important agronomic characters which directly relate to yield in rice. Grain number (GN), panicle length (PL), primary branch number (PBN), and secondary branch number (SBN) are the major components of rice panicle structure, and are all controlled by quantitative trait loci (QTLs). In our research, four advanced backcross overlapping populations (BIL152, BIL196a, BIL196b, and BIL196b-156) carrying introgressed segments from chromosome 6 were derived from an indica/japonica cross that used the super-hybrid rice restorer line HR1128 and the international sequenced japonica cultivar 'Nipponbare' as the donor and recurrent parents, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28421098/fine-mapping-the-branching-habit-trait-in-cultivated-peanut-by-combining-bulked-segregant-analysis-and-high-throughput-sequencing
#9
Galya Kayam, Yael Brand, Adi Faigenboim-Doron, Abhinandan Patil, Ilan Hedvat, Ran Hovav
The growth habit of lateral shoots (also termed "branching habit") is an important descriptive and agronomic character of peanut. Yet, both the inheritance of branching habit and the genetic mechanism that controls it in this crop remain unclear. In addition, the low degree of polymorphism among cultivated peanut varieties hinders fine-mapping of this and other traits in non-homozygous genetic structures. Here, we combined high-throughput sequencing with a well-defined genetic system to study these issues in peanut...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28420804/contemporary-trends-and-outcomes-associated-with-the-preprocedural-use-of-oral-p2y12-inhibitors-in-patients-undergoing-percutaneous-coronary-intervention-insights-from-the-blue-cross-blue-shield-of-michigan-cardiovascular-consortium-bmc2
#10
Devraj Sukul, Milan Seth, Simon R Dixon, Akshay Khandelwal, Thomas A LaLonde, Hitinder S Gurm
OBJECTIVES: We sought to describe trends in the use of preprocedural P2Y12 inhibitors and their clinical impact in patients undergoing percutaneous coronary intervention (PCI). BACKGROUND: Oral P2Y12 inhibitors are ubiquitously used medications; however, the specific timing of initial P2Y12 inhibitor administration remains intensely debated. METHODS: Our study population comprised 74,053 consecutive patients undergoing PCI at 47 hospitals in Michigan from January 2013 through June 2015...
April 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28420605/scalable-passive-sleep-monitoring-using-mobile-phones-opportunities-and-obstacles
#11
Sohrab Saeb, Thaddeus R Cybulski, Konrad P Kording, David C Mohr
BACKGROUND: Sleep is a critical aspect of people's well-being and as such assessing sleep is an important indicator of a person's health. Traditional methods of sleep assessment are either time- and resource-intensive or suffer from self-reporting biases. Recently, researchers have started to use mobile phones to passively assess sleep in individuals' daily lives. However, this work remains in its early stages, having only examined relatively small and homogeneous populations in carefully controlled contexts...
April 18, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28420131/work-characteristics-associated-with-physical-functioning-in-women
#12
Aimee J Palumbo, Anneclaire J De Roos, Carolyn Cannuscio, Lucy Robinson, Jana Mossey, Julie Weitlauf, Lorena Garcia, Robert Wallace, Yvonne Michael
Women make up almost half of the labor force with older women becoming a growing segment of the population. Work characteristics influence physical functioning and women are at particular risk for physical limitations. However, little research has explored the effects of work characteristics on women's physical functioning. U.S. women between the ages of 50 and 79 were enrolled in the Women's Health Initiative Observational Study between 1993 and 1998. Women provided job titles and years worked at their three longest-held jobs (n = 79,147)...
April 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28419329/effects-of-the-inclusion-of-a-bacillus-direct-fed-microbial-on-performance-parameters-bone-quality-recovered-gut-microflora-and-intestinal-morphology-in-broilers-consuming-a-grower-diet-containing-corn-distillers-dried-grains-with-solubles
#13
J D Latorre, X Hernandez-Velasco, J L Vicente, R Wolfenden, B M Hargis, G Tellez
Distillers dried grains with solubles (DDGS) have increasingly been used in poultry diets as a consequence of rising grain costs. Some, but not all, sources of DDGS have a variable compositional value, and a high inclusion of this by-product could be considered a risk factor for presentation of enteric diseases. Presently, 2 experiments were conducted using a starter corn-soybean diet (zero to 7 d) and a corn-DDGS-soybean grower diet (8 to 28 d) with or without inclusion of a Bacillus-direct-fed microbial (DFM)...
April 17, 2017: Poultry Science
https://www.readbyqxmd.com/read/28417608/comparison-of-antithrombotic-agents-during-urgent-percutaneous-coronary-intervention-following-thrombolytic-therapy-a-retrospective-cohort-study
#14
Jaya R Mallidi, Peter Robinson, Paul F Visintainer, Amir S Lotfi, Scott Mulvey, Gregory R Giugliano
BACKGROUND: The optimal antithrombotic regimen for urgent percutaneous coronary interventions (PCI) following thrombolytic therapy for ST segment myocardial infarction (STEMI) is currently unknown. METHODS: We performed a retrospective analysis of all patients referred to our institution from January 2005 to July 2014 who underwent urgent PCI within 24 hr after receiving thrombolytic therapy. The patients were divided into three cohorts based on the anticoagulation strategy during PCI-bivalirudin, heparin alone or heparin plus Glycoprotein IIb/IIIa inhibitor (GPI)...
April 18, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28417258/in-vivo-facial-soft-tissue-depths-of-a-modern-adult-population-from-germany
#15
Nicolle Thiemann, Volker Keil, Uwe Roy
Forensic facial reconstruction may be the final option available to draw public attention in cases where the identity of an individual cannot be established by standard identification methods. Two fundamental components of all forensic facial reconstruction techniques are cranial morphology and soft tissue depth databases. The purpose of this study was to extend such databases by providing a complete set of accurate facial soft tissue thickness measurements, acquired from a contemporary adult population from Germany...
April 17, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28417145/relationship-in-pacemaker-neurons-between-the-long-term-correlations-of-membrane-voltage-fluctuations-and-the-corresponding-duration-of-the-inter-spike-interval
#16
Alberto Seseña Rubfiaro, José Rafael Godínez, Juan Carlos Echeverría
Several studies of the behavior in the voltage and frequency fluctuations of the neural electrical activity have been performed. Here, we explored the particular association between behavior of the voltage fluctuations in the inter-spike segment (VFIS) and the inter-spike intervals (ISI) of F1 pacemaker neurons from H. aspersa, by disturbing the intracellular calcium handling with cadmium and caffeine. The scaling exponent α of the VFIS, as provided by detrended fluctuations analysis, in conjunction with the corresponding duration of ISI to estimate the determination coefficient R (2) (48-50 intervals per neuron, N = 5) were all evaluated...
April 17, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28416467/early-repolarization-is-associated-with-significantly-increased-risk-for-ventricular-arrhythmias-and-sudden-cardiac-death-in-patients-with-structural-heart-diseases
#17
Yun-Jiu Cheng, Zhu-Yu Li, Feng-Juan Yao, Xiong-Jun Xu, Cheng-Cheng Ji, Xu-Miao Chen, Li-Juan Liu, Xiao-Xiong Lin, Hao Yao, Su-Hua Wu
BACKGROUND: Early repolarization pattern (ERP) has been proved to increase risk of arrhythmia death in the general population, but its prognostic significance in subjects with structural heart disease (SHD) is controversial. OBJECTIVE: To conduct a meta-analysis of studies assessing the association between ERP and risk of ventricular arrhythmias (VTAs) and sudden cardiac death (SCD) in patients with SHD. METHODS: We performed a literature search using MEDLINE (January 1, 1966 to September25, 2016) and EMBASE (January 1, 1980 to September25, 2016) with no restrictions...
April 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28412420/stress-perfusion-cmr-in-patients-with-known-and-suspected-cad-prognostic-value-and-optimal-ischemic-threshold-for-revascularization
#18
Gabriella Vincenti, Pier Giorgio Masci, Pierre Monney, Tobias Rutz, Sarah Hugelshofer, Mirdita Gaxherri, Olivier Muller, Juan F Iglesias, Eric Eeckhout, Valentina Lorenzoni, Cyril Pellaton, Christophe Sierro, Juerg Schwitter
OBJECTIVES: This study sought to determine the ischemia threshold and additional prognostic factors that identify patients for safe deferral from revascularizations in a large cohort of all-comer patients with known or suspected coronary artery disease (CAD). BACKGROUND: Stress-perfusion cardiac magnetic resonance (CMR) is increasingly used in daily practice for ischemia detection. However, there is insufficient evidence about the ischemia burden that identifies patients who benefit from revascularization versus those with a good prognosis who receive drugs only...
April 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28411350/acute-appendicitis-somatosensory-disturbances-head-zones-and-the-differential-diagnosis-of-anterior-cutaneous-nerve-entrapment-syndrome-acnes
#19
Rudi M H Roumen, Wouter Vening, Rosanne Wouda, Marc M Scheltinga
BACKGROUND: Anterior cutaneous nerve entrapment syndrome (ACNES) is a neuropathic abdominal wall pain syndrome typically characterized by locally altered skin sensations. On the other hand, visceral disease may also be associated with similar painful and altered skin sensations ("Head zones"). Aim of the study was to determine if patients with acute appendicitis demonstrated somatosensory disturbances in the corresponding right lower quadrant Head zone. METHODS: The presence of somatosensory disturbances such as hyperalgesia, hypoesthesia, altered cool perception, or positive pinch test was determined in 100 patients before and after an appendectomy...
April 14, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28409346/development-and-diseases-of-the-collecting-duct-system
#20
Lihe Chen, Paul J Higgins, Wenzheng Zhang
The collecting duct of the mammalian kidney is important for the regulation of extracellular volume, osmolarity, and pH. There are two major structurally and functionally distinct cell types: principal cells and intercalated cells. The former regulates Na(+) and water homeostasis, while the latter participates in acid-base homeostasis. In vivo lineage tracing using Cre recombinase or its derivatives such as CreGFP and CreER(T2) is a powerful new technique to identify stem/progenitor cells in their native environment and to decipher the origins of the tissue that they give rise to...
2017: Results and Problems in Cell Differentiation
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