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https://www.readbyqxmd.com/read/28730413/updating-the-elite-rice-variety-kongyu-131-by-improving-the-gn1a-locus
#1
Xiaomin Feng, Chen Wang, Jianzong Nan, Xiaohui Zhang, Rongsheng Wang, Guoqiang Jiang, Qingbo Yuan, Shaoyang Lin
BACKGROUND: Kongyu 131 is an elite japonica rice variety of Heilongjiang Province, China. It has the characteristics of early maturity, superior quality, high yield, cold tolerance and wide adaptability. However, there is potential to improve the yield of Kongyu 131 because of the relatively few grains per panicle compared with other varieties. Hence, we rebuilt the genome of Kongyu 131 by replacing the GRAIN NUMBER1a (Gn1a) locus with a high-yielding allele from a big panicle indica rice variety, GKBR...
December 2017: Rice
https://www.readbyqxmd.com/read/28727105/analysis-of-the-gut-bacterial-communities-in-beef-cattle-and-their-association-with-feed-intake-growth-and-efficiency
#2
P R Myer, H C Freetly, J E Wells, T P L Smith, L A Kuehn
The impetus behind the global food security challenge is direct, with the necessity to feed almost 10 billion people by 2050. Developing a food-secure world, where people have access to a safe and sustainable food supply, is the principal goal of this challenge. To achieve this end, beef production enterprises must develop methods to produce more pounds of animal protein with less. Selection for feed-efficient beef cattle using genetic improvement technologies has helped to understand and improve the stayability and longevity of such traits within the herd...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28725485/segmentation-errors-in-macular-ganglion-cell-analysis-as-determined-by-optical-coherence-tomography-in-eyes-with-macular-pathology
#3
Rayan A Alshareef, Abhilash Goud, Mikel Mikhail, Hady Saheb, Hari Kumar Peguda, Sunila Dumpala, Shruthi Rapole, Jay Chhablani
BACKGROUND: To evaluate artifacts in macular ganglion cell inner plexiform layer (GCIPL) thickness measurement in eyes with retinal pathology using spectral-domain optical coherence tomography (SD OCT). METHODS: Retrospective analysis of color-coded maps, infrared images and 128 horizontal B-scans (acquired in the macular ganglion cell inner plexiform layer scans), using the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA). The study population included 105 eyes with various macular conditions compared to 30 eyes of 30 age-matched healthy volunteers...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28725363/bridging-two-scholarly-islands-enriches-both-coi-dna-barcodes-for-species-identification-versus-human-mitochondrial-variation-for-the-study-of-migrations-and-pathologies
#4
David S Thaler, Mark Y Stoeckle
DNA barcodes for species identification and the analysis of human mitochondrial variation have developed as independent fields even though both are based on sequences from animal mitochondria. This study finds questions within each field that can be addressed by reference to the other. DNA barcodes are based on a 648-bp segment of the mitochondrially encoded cytochrome oxidase I. From most species, this segment is the only sequence available. It is impossible to know whether it fairly represents overall mitochondrial variation...
October 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/28724652/correlation-of-admission-heart-rate-with-angiographic-and-clinical-outcomes-in-patients-with-right-coronary-artery-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention-horizons-ami-the-harmonizing-outcomes-with-revascularization
#5
Ioanna Kosmidou, Thomas McAndrew, Björn Redfors, Monica Embacher, José M Dizon, Roxana Mehran, Ori Ben-Yehuda, Gary S Mintz, Gregg W Stone
BACKGROUND: Bradycardia on presentation is frequently observed in patients with right coronary artery ST-segment elevation myocardial infarction, but it is largely unknown whether it predicts poor angiographic or clinical outcomes in that patient population. We sought to determine the prognostic implications of admission heart rate (AHR) in patients with ST-segment elevation myocardial infarction and a right coronary artery culprit lesion. METHODS AND RESULTS: We analyzed 1460 patients with ST-segment elevation myocardial infarction and a right coronary artery culprit lesion enrolled in the randomized HORIZONS-AMI (Harmonizing Outcomes with Revascularization and Stents in Acute Myocardial Infarction) trial who underwent primary percutaneous coronary intervention...
July 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28724433/gridsample-an-r-package-to-generate-household-survey-primary-sampling-units-psus-from-gridded-population-data
#6
Dana R Thomson, Forrest R Stevens, Nick W Ruktanonchai, Andrew J Tatem, Marcia C Castro
BACKGROUND: Household survey data are collected by governments, international organizations, and companies to prioritize policies and allocate billions of dollars. Surveys are typically selected from recent census data; however, census data are often outdated or inaccurate. This paper describes how gridded population data might instead be used as a sample frame, and introduces the R GridSample algorithm for selecting primary sampling units (PSU) for complex household surveys with gridded population data...
July 19, 2017: International Journal of Health Geographics
https://www.readbyqxmd.com/read/28721146/the-role-of-selected-adipokines-and-ghrelin-in-the-prognosis-after-myocardial-infarction-in-a-12-month-follow-up-in-the-presence-of-metabolic-syndrome
#7
Błażej Michalski, Ewa Szymczyk, Lukasz Peczek, Barbara Nawrot, Karolina Kupczynska, Maria Krzemińska-Pakuła, Jan Z Peruga, Piotr Lipiec, Jarosław D Kasprzak
INTRODUCTION: The aim of this study was to evaluate the predictive value of selected adipokines in the improvement in the ejection fraction and in the development of adverse cardiac remodeling during 12 months of follow-up among patients with an ST-segment elevation acute myocardial infarction (STEMI) in the presence of metabolic syndrome (MeS). MATERIAL AND METHODS: The study population consisted of 69 patients (49 male; mean age: 59 ±10 years) with a first STEMI that was treated with a primary percutaneous coronary intervention (pPCI)...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28719068/correlation-between-the-proportion-of-stained-eggs-and-the-number-of-mites-dermanyssus-gallinae-monitored-using-a-non-parallel-board-trap
#8
Makiko Odaka, Kazumasa Ogino, Michitaka Shikada, Kenichi Asada, Syoujirou Kasa, Takahiro Inoue, Ken Maeda
The poultry red mite (Dermanyssus gallinae) is a serious problem for the poultry industry worldwide. However, the relationship between the mite population and the damage that they cause is still unclear. In this study, the mite population in poultry houses was examined using an established trap method, and the risk of blood-stained eggs caused by the mites was assessed. Traps were placed once a week outside the egg channels and/or on the floor in two poultry farms in Fukuoka Prefecture, Japan, from April 2012 to July 2014...
July 18, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28718077/early-risk-stratification-using-rubidium-82-positron-emission-tomography-in-stemi-patients
#9
Adam Ali Ghotbi, Philip Hasbak, Lars Nepper-Christensen, Jacob Lønborg, Kiril Atharovski, Thomas Christensen, Lene Holmvang, Thomas Engstrøm, Rasmus Sejersten Ripa, Andreas Kjær
BACKGROUND: Assessment of infarct size after myocardial infarction is predictive of subsequent morphological changes and clinical outcome. This study aimed to assess subacute post-intervention Rubidium-82 ((82)Rb)-PET imaging in predicting left ventricle ejection fraction, regional wall motion, and final infarct size by CMR at 3-months after STEMI. METHODS: STEMI patients undergoing percutaneous coronary intervention were included prospectively. Rest-only (82)Rb-PET perfusion imaging was performed at median 36 hours [IQR: 22 to 50] after the treatment...
July 17, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28717743/chronic-myeloid-leukemia-in-india
#10
REVIEW
Prasanth Ganesan, Lalit Kumar
BACKGROUND: In the last decade, the use of imatinib has brought a paradigm shift in the management of chronic myeloid leukemia (CML). In India, imatinib has been available for more than a decade and has been made accessible to all segments of the population because of patient assistance programs and cheaper generic versions. Despite improvements in survival, there are unique challenges in the Indian context. METHODS: We reviewed published data pertaining to CML in India for the period of 1990 to 2016, using PubMed advanced search with the terms chronic myeloid leukemia and India, and included studies that reported on epidemiology, monitoring for therapy, treatment outcomes, and resistance...
February 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28717047/annotated-draft-genome-assemblies-for-the-northern-bobwhite-colinus-virginianus-and-the-scaled-quail-callipepla-squamata-reveal-disparate-estimates-of-modern-genome-diversity-and-historic-effective-population-size
#11
David L Oldeschulte, Yvette A Halley, Miranda L Wilson, Eric K Bhattarai, Wesley Brashear, Joshua Hill, Richard P Metz, Charles D Johnson, Dale Rollins, Markus J Peterson, Derek M Bickhart, Jared E Decker, John F Sewell, Christopher M Seabury
Northern bobwhite (Colinus virginianus; hereafter bobwhite) and scaled quail (Callipepla squamata) populations have suffered precipitous declines across most of their U.S. ranges. Illumina-based first- (v1.0) and second-generation (v2.0) draft genome assemblies for the scaled quail and the bobwhite produced N50 scaffold sizes of 1.035 Mb and 2.042 Mb, thereby producing a 45-fold improvement in contiguity over the existing bobwhite assembly, and ≥ 90% of the assembled genomes were captured within 1,313 and 8,990 scaffolds, respectively...
July 17, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28716917/diverse-continuum-of-cd4-t-cell-states-is-determined-by-hierarchical-additive-integration-of-cytokine-signals
#12
Inbal Eizenberg-Magar, Jacob Rimer, Irina Zaretsky, David Lara-Astiaso, Shlomit Reich-Zeliger, Nir Friedman
During cell differentiation, progenitor cells integrate signals from their environment that guide their development into specialized phenotypes. The ways by which cells respond to complex signal combinations remain difficult to analyze and model. To gain additional insight into signal integration, we systematically mapped the response of CD4(+) T cells to a large number of input cytokine combinations that drive their differentiation. We find that, in response to varied input combinations, cells differentiate into a continuum of cell fates as opposed to a limited number of discrete phenotypes...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28716553/regional-analysis-of-age-related-local-bone-loss-in-the-spine-of-a-healthy-population-using-3d-voxel-based-modeling
#13
Alexander Valentinitsch, Stefano Trebeschi, Eva Alarcón, Thomas Baum, Johannes Kaesmacher, Claus Zimmer, Cristian Lorenz, Jan S Kirschke
Local variations in bone loss may be of great importance to individually predict osteoporotic fractures but are neglected by current densitometry techniques. The purpose of this study was to evaluate regional variations of normal bone loss at the spine among different age groups using voxel-based morphometry. Non-contrast MDCT scans of 16 patients under the age of 40 (mean age 26years) without spinal pathology were identified as a reference cohort, where each thoracolumbar vertebra was assessed individually...
July 14, 2017: Bone
https://www.readbyqxmd.com/read/28715558/prevalence-of-intracranial-aneurysm-in-women-with-fibromuscular-dysplasia-a-report-from-the-us-registry-for-fibromuscular-dysplasia
#14
Henry D Lather, Heather L Gornik, Jeffrey W Olin, Xiaokui Gu, Steven T Heidt, Esther S H Kim, Daniella Kadian-Dodov, Aditya Sharma, Bruce Gray, Michael R Jaff, Yung-Wei Chi, Pamela Mace, Eva Kline-Rogers, James B Froehlich
Importance: The prevalence of intracranial aneurysm in patients with fibromuscular dysplasia (FMD) is uncertain. Objective: To examine the prevalence of intracranial aneurysm in women diagnosed with FMD. Design, Setting, and Participants: This cross-sectional study included 669 women with intracranial imaging registered in the US Registry for Fibromuscular Dysplasia, an observational disease-based registry of patients with FMD confirmed by vascular imaging and currently enrolling at 14 participating US academic centers...
July 17, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28715070/evaluation-of-the-relationship-between-renal-resistive-index-and-extensivity-and-complexity-of-coronary-artery-disease-in-patients-with-acute-coronary-syndrome
#15
Alaa Quisi, Ibrahim Halil Kurt, Durmuş Yıldıray Şahin, Onur Kaypaklı, Gökhan Söker, Ömer Kaya, Samir Allahverdiyev, Ömer Genç, Gökhan Alıcı, Mevlüt Koç
BACKGROUND: Despite the advances in cardiovascular medicine, acute coronary syndrome (ACS) is still a major cause of morbidity and mortality worldwide. Synergy between PCI ™ with TAXUS and Cardiac Surgery (SYNTAX) score is used to determine the extensivity and complexity of coronary artery disease (CAD). Renal resistive index (RRI), a renal Doppler ultrasound parameter, is used to detect renal hemodynamics. Although some risk factors for CAD, including hypertension and diabetes mellitus were demonstrated to have an association with RRI, direct relationship between the presence...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28714755/foot-and-ankle-kinematics-during-descent-from-varying-step-heights
#16
Emily E Gerstle, Kristian O'Connor, Kevin G Keenan, Stephen C Cobb
In the general population, one-third of incidences during step negotiation occur during the transition to level walking. Furthermore, falls during curb negotiation are a common cause injury in older adults. Distal foot kinematics may be an important factor in determining injury risk associated with transition step negotiation. The purpose of this study was to identify foot and ankle kinematics of uninjured individuals during descent from varying step heights. A seven-segment foot model was used to quantify kinematics as participants walked on a level walkway, stepped down a single step (heights: 5 cm, 15 cm, 25 cm) and continued walking...
July 17, 2017: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/28714672/chemical-denaturants-smoothen-ruggedness-on-the-free-energy-landscape-of-protein-folding
#17
Pooja Malhotra, Prashant Navalbhai Jethva, Jayant B Udgaonkar
To characterize experimentally the ruggedness of the free energy landscape of protein folding is challenging, because the distributed small free energy barriers are usually dominated by one or a few, large activation free energy barriers. The present study delineates changes in the roughness of the free energy landscape by making use of the observation that a decrease in ruggedness is accompanied invariably by an increase in folding cooperativity. Hydrogen exchange coupled to mass spectrometry (HX-MS) was used to detect transient sampling of local energy minima and the global unfolded state on the free energy landscape of the small protein, single chain monellin...
July 17, 2017: Biochemistry
https://www.readbyqxmd.com/read/28713347/generic-amplicon-deep-sequencing-to-determine-ilarvirus-species-diversity-in-australian-prunus
#18
Wycliff M Kinoti, Fiona E Constable, Narelle Nancarrow, Kim M Plummer, Brendan Rodoni
The distribution of Ilarvirus species populations amongst 61 Australian Prunus trees was determined by next generation sequencing (NGS) of amplicons generated using a genus-based generic RT-PCR targeting a conserved region of the Ilarvirus RNA2 component that encodes the RNA dependent RNA polymerase (RdRp) gene. Presence of Ilarvirus sequences in each positive sample was further validated by Sanger sequencing of cloned amplicons of regions of each of RNA1, RNA2 and/or RNA3 that were generated by species specific PCRs and by metagenomic NGS...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28712176/ecg-abnormalities-in-patients-with-chronic-kidney-disease
#19
Salman Shafi, Mohammad Saleem, Roshina Anjum, Wajid Abdullah, Tahir Shafi
BACKGROUND: Chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease. Electrocardiographic (ECG) abnormalities are common in CKD patients. However, there is variation in literature regarding frequency of ECG abnormalities in CKD patients and limited information in local population. METHODS: The study design was cross-sectional in nature. All patients between ages of 20-80 years with CKD not previously on renal replacement therapy who were admitted to nephrology ward at a tertiary care facility over a 6-month period were included...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28711131/care-of-special-populations-in-an-observation-unit-pediatrics-and-geriatrics
#20
REVIEW
Sharon E Mace
Infants and children and the elderly comprise a large and growing (especially the elderly) segment of the US population. The benefits of observation medicine have been documented in these two age groups: Based on the success of observation medicine, and recognizing the growth of these special populations, it is likely that observation medicine will be expanding in the future, especially within the pediatric and geriatric populations. Future studies should be able to provide further evidence regarding the value of observation medicine in these two diverse population age groups...
August 2017: Emergency Medicine Clinics of North America
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