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https://www.readbyqxmd.com/read/29684373/racial-disparity-in-utilization-of-high-volume-hospitals-for-surgical-treatment-of-esophageal-cancer
#1
Sadiq S Rehmani, Bian Liu, Adnan Al-Ayoubi, Wissam Raad, Raja M Flores, Faiz Bhora, Emanuela Taioli
BACKGROUND: Utilization of high-volume hospitals (HVH) for esophagectomy has been associated with improved perioperative outcomes and reduced mortality. We aimed to test the hypothesis that black-white racial disparities exist in HVH utilization, and to identify predictors of in-hospital surgical outcomes of esophageal cancer while adjusting for HVH utilization patterns. METHODS: We queried the New York Statewide Planning and Research Cooperative System (SPARCS) database (1995-2012) for esophageal cancer patients who underwent surgical resection exclusively...
April 20, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29682509/initiation-and-propagation-of-vascular-calcification-is-regulated-by-a-concert-of-platelet-and-smooth-muscle-cell-derived-extracellular-vesicles
#2
Leon J Schurgers, Asim C Akbulut, Dawid M Kaczor, Maurice Halder, Rory R Koenen, Rafael Kramann
The ageing population continues to suffer from its primary killer, cardiovascular disease (CVD). Despite recent advances in interventional medicinal and surgical therapies towards the end of the 20th century, the epidemic of cardiovascular disease has not been halted. Yet, rather than receding globally, the burden of CVD has risen to become a top cause of morbidity and mortality worldwide. Most CVD arises from thrombotic rupture of an atherosclerotic plaque, the pathologic thickening of coronary and carotid artery segments and subsequent distal ischemia in heart or brain...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29680969/construction-of-avulsion-potential-zone-model-for-kulik-river-of-barind-tract-india-and-bangladesh
#3
Debabrata Sarkar, Swades Pal
Avulsion is a natural fluvial process but considered it as a hazard in the populated region due to the chance of immense failure of lives and properties. So, early warning indicates that the zone of avulsion can facilitate the people living there. About 317 numbers of local and regional historical imprints of channel cutoff along river Kulik claim the need of this work. The present study tried to identify avulsion potential zone (APZ) of Kulik river of Indo-Bangladesh using multi-parametric weighted combination approach...
April 21, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29676260/embryonic-and-postnatal-neurogenesis-produce-functionally-distinct-subclasses-of-dopaminergic-neuron
#4
Elisa Galliano, Eleonora Franzoni, Marine Breton, Annisa N Chand, Darren J Byrne, Venkatesh N Murthy, Matthew Grubb
Most neurogenesis in the mammalian brain is completed embryonically, but in certain areas the production of neurons continues throughout postnatal life. The functional properties of mature postnatally-generated neurons often match those of their embryonically-produced counterparts. However, we show here that in the olfactory bulb (OB), embryonic and postnatal neurogenesis produce functionally distinct subpopulations of dopaminergic (DA) neurons. We define two subclasses of OB DA neuron by the presence or absence of a key subcellular specialisation: the axon initial segment (AIS)...
April 20, 2018: ELife
https://www.readbyqxmd.com/read/29675645/fine-mapping-and-identification-of-a-novel-locus-qgl12-2-control-grain-length-in-wild-rice-oryza-rufipogon-griff
#5
Lan Qi, Yingbin Ding, Xiaoming Zheng, Rui Xu, Lizhen Zhang, Yanyan Wang, Xiaoning Wang, Lifang Zhang, Yunlian Cheng, Weihua Qiao, Qingwen Yang
A wild rice QTL qGL12.2 for grain length was fine mapped to an 82-kb interval in chromosome 12 containing six candidate genes and none was reported previously. Grain length is an important trait for yield and commercial value in rice. Wild rice seeds have a very slender shape and have many desirable genes that have been lost in cultivated rice during domestication. In this study, we identified a quantitative trait locus, qGL12.2, which controls grain length in wild rice. First, a wild rice chromosome segment substitution line, CSSL41, was selected that has longer glume and grains than does the Oryza sativa indica cultivar, 9311...
April 19, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29675301/deep-learning-approach-for-the-detection-and-quantification-of-intraretinal-cystoid-fluid-in-multivendor-optical-coherence-tomography
#6
Freerk G Venhuizen, Bram van Ginneken, Bart Liefers, Freekje van Asten, Vivian Schreur, Sascha Fauser, Carel Hoyng, Thomas Theelen, Clara I Sánchez
We developed a deep learning algorithm for the automatic segmentation and quantification of intraretinal cystoid fluid (IRC) in spectral domain optical coherence tomography (SD-OCT) volumes independent of the device used for acquisition. A cascade of neural networks was introduced to include prior information on the retinal anatomy, boosting performance significantly. The proposed algorithm approached human performance reaching an overall Dice coefficient of 0.754 ± 0.136 and an intraclass correlation coefficient of 0...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29674436/mapping-of-leaf-rust-resistance-genes-and-molecular-characterization-of-the-2ns-2as-translocation-in-the-wheat-cultivar-jagger
#7
Shulin Xue, James A Kolmer, Shuwen Wang, Liuling Yan
Winter wheat cultivar 'Jagger' was recently found to have an alien chromosomal segment 2NS that has Lr37 , a gene conferring resistance against leaf rust caused by Puccinia triticina The objective of this study was to map and characterize the gene(s) for seedling leaf rust resistance in Jagger. The recombinant inbred line (RIL) population of Jagger × '2174' was inoculated with leaf rust pathogen THBJG and BBBDB, and evaluated for infection type (IT) response. A major quantitative trait locus (QTL) for THBJG and BBBDB was coincidently mapped to chromosome arm 2AS, and the QTL accounted for 56...
April 19, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29673904/impact-of-2-successive-smoking-bans-on-hospital-admissions-for-cardiovascular-diseases-in-spain
#8
Iñaki Galán, Lorena Simón, Elena Boldo, Cristina Ortiz, María José Medrano, Rafael Fernández-Cuenca, Cristina Linares, Roberto Pastor-Barriuso
INTRODUCTION AND OBJECTIVES: To evaluate the impact of 2 smoking bans enacted in 2006 (partial ban) and 2011 (comprehensive ban) on hospitalizations for cardiovascular disease in the Spanish adult population. METHODS: The study was performed in 14 provinces in Spain. Hospital admission records were collected for acute myocardial infarction (AMI), ischemic heart disease (IHD), and cerebrovascular disease (CVD) in patients aged ≥ 18 years from 2003 through 2012...
April 16, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29673320/intraspecific-variation-of-residual-heterozygosity-and-its-utility-for-quantitative-genetic-studies-in-maize
#9
Nannan Liu, Jianxiao Liu, Wenqiang Li, Qingchun Pan, Jie Liu, Xiaohong Yang, Jianbing Yan, Yingjie Xiao
BACKGROUND: Residual heterozygosity (RH) in advanced inbred lines of plants benefits quantitative trait locus (QTL) mapping studies. However, knowledge of factors affecting the genome-wide distribution of RH remains limited. RESULTS: A set of 2196 heterogeneous inbred family (HIF) maize lines derived from 12 recombinant inbred line (RIL) populations was genotyped using the Maize50K SNP chip. A total of 18,615 unique RH intervals were identified, ranging from 505 to 2095 intervals per population, with average maize genome coverage of 94...
April 19, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29671389/modeling-and-correct-the-gc-bias-of-tumor-and-normal-wgs-data-for-scna-based-tumor-subclonal-population-inferring
#10
Yanshuo Chu, Mingxiang Teng, Yadong Wang
BACKGROUND: Somatic copy number alternations (SCNAs) can be utilized to infer tumor subclonal populations in whole genome seuqncing studies, where usually their read count ratios between tumor-normal paired samples serve as the inferring proxy. Existing SCNA based subclonal population inferring tools consider the GC bias of tumor and normal sample is of the same fature, and could be fully offset by read count ratio. However, we found that, the read count ratio on SCNA segments presents a Log linear biased pattern, which influence existing read count ratios based subclonal inferring tools performance...
April 11, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29671324/discovery-of-lipidome-alterations-following-traumatic-brain-injury-via-high-resolution-metabolomics
#11
Scott R Hogan, John H Phan, Melissa Alvarado-Velez, May Dongmei Wang, Ravi V Bellamkonda, Facundo M Fernandez, Michelle C LaPlaca
Traumatic brain injury (TBI) can occur across wide segments of the population, presenting in a heterogeneous manner that makes diagnosis inconsistent and management challenging. Biomarkers offer the potential to objectively identify injury status, severity, and phenotype by measuring the relative concentrations of endogenous molecules in readily accessible biofluids. Through a data-driven, discovery approach, novel biomarker candidates for TBI were identified in the serum lipidome of adult male Sprague-Dawley rats in the first week following moderate controlled cortical impact (CCI)...
April 19, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29671107/the-etiology-of-congenital-scoliosis-genetic-vs-environmental-a-report-of-three-monozygotic-twin-cases
#12
REVIEW
Woojin Cho, Nicholas Shepard, Vincent Arlet
PURPOSE: To describe the presence of congenital scoliosis in a genetically identical population as it relates to the possible genetic vs. environmental etiologic factors. METHODS: The authors describe three cases of congenital scoliosis in monozygotic twins. The first pair includes two 4-year-old girls presenting with mirror curves, one of whom had an associated stage I Chiari malformation. The second pair is a 4-year-old girl who presented with thoracic scoliosis, a T10-11 hemivertebra, and multilevel failure of segmentation in the lumbar spine whose identical sibling is unaffected...
April 18, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29670420/first-records-of-the-genus-pelionella-kaydan-2015-in-east-asia-with-description-of-a-new-species-hemiptera-coccomorpha-pseudococcidae
#13
Hirotaka Tanaka
Two mealybug species (Hemiptera: Coccomorpha: Pseudococcidae), Pelionella osakaensis sp. n. and P. manifecta (Borchsenius, 1949), are described and illustrated based on adult female specimens collected in Japan, on the Japanese mugwort Artemisia indica Willd. var. maximowiczii (Nakai) H. Hara (Asteraceae). These are the first records of the occurrence of Pelionella species in East Asia. The new species is similar to P. grassiana (Goux, 1989) and P. proeminens (Goux, 1990), but differs in lacking multilocular pores with double loculi rings on the venter and in possessing dorsal cerarii and a circulus...
2018: ZooKeys
https://www.readbyqxmd.com/read/29668846/movement-decomposition-in-the-primary-motor-cortex
#14
Naama Kadmon Harpaz, David Ungarish, Nicholas G Hatsopoulos, Tamar Flash
A complex action can be described as the composition of a set of elementary movements. While both kinematic and dynamic elements have been proposed to compose complex actions, the structure of movement decomposition and its neural representation remain unknown. Here, we examined movement decomposition by modeling the temporal dynamics of neural populations in the primary motor cortex of macaque monkeys performing forelimb reaching movements. Using a hidden Markov model, we found that global transitions in the neural population activity are associated with a consistent segmentation of the behavioral output into acceleration and deceleration epochs with directional selectivity...
April 13, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29665924/-analysis-of-phenotype-and-l12r-mutation-in-signal-peptide-and-3-non-translation-region-c11814-insaa-mutation-of-f7-gene-in-a-family-with-hereditary-coagulation-factor-vii-deficiency
#15
Shan Liu, Jing-Yu Zhang, Zheng-Rong Li, Yan Wang, Zhi-Yun Niu, Feng-Ru Lin
OBJECTIVE: To examine one young female patient with hereditary FVII deficiency and her family members, to observe the gene mutation and clinical phenotype, and to investigate the molecular mechanism of the dysfunction. METHODS: Prothrombin time (PT), activated partial thromoploastin time (APTT), fibrinogen (Fg) and FVII activity (FVII:C) and FVII antigen (FVII:Ag) were tested. The gene mutations were sought by DNA sequencing for all of the exons and flanks, 5' and 3' non-translation region of F7 gene...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29665854/a-community-based-physical-activity-intervention-to-prevent-mobility-related-disability-for-retired-older-people-retirement-in-action-react-study-protocol-for-a-randomised-controlled-trial
#16
Afroditi Stathi, Janet Withall, Colin J Greaves, Janice L Thompson, Gordon Taylor, Antonieta Medina-Lara, Colin Green, James Bilzon, Selena Gray, Heidi Johansen-Berg, Claire E Sexton, Max J Western, Jolanthe L de Koning, Jessica C Bollen, Sarah J Moorlock, Naiara Demnitz, Poppy Seager, Jack M Guralnik, W Jack Rejeski, Ken R Fox
BACKGROUND: The REtirement in ACTion (REACT) study is a multi-centre, pragmatic, two-arm, parallel-group randomised controlled trial (RCT) with an internal pilot phase. It aims to test the effectiveness and cost-effectiveness of a community, group-based physical activity intervention for reducing, or reversing, the progression of functional limitations in older people who are at high risk of mobility-related disability. METHODS/DESIGN: A sample of 768 sedentary, community-dwelling, older people aged 65 years and over with functional limitations, but who are still ambulatory (scores between 4 and 9 out of 12 in the Short Physical Performance Battery test (SPPB)) will be randomised to receive either the REACT intervention, delivered over a period of 12 months by trained facilitators, or a minimal control intervention...
April 17, 2018: Trials
https://www.readbyqxmd.com/read/29664423/long-term-follow-up-of-antithrombotic-management-patterns-in-acute-coronary-syndrome-patients
#17
Fatih Sinan Ertaş, Lale Tokgozoglu
OBJECTIVE: The aim of this study was to evaluate the longterm, post-discharge follow-up of antithrombotic management patterns (AMPs), clinical outcomes, and real-life health status of patients hospitalized acute coronary syndrome (ACS). METHODS: A total of 1034 patients hospitalized for ACS within 24 hours of symptom onset who survived to discharge were included. Of those, 514 had ST-segment elevation myocardial infarction (STEMI) and 520 had unstable angina (UA)/non-STEMI (NSTEMI)...
April 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29663370/deformable-torso-phantoms-of-chinese-adults-for-personalized-anatomy-modelling
#18
Hongkai Wang, Xiaobang Sun, Tongning Wu, Congsheng Li, Zhonghua Chen, Meiying Liao, Mengci Li, Wen Yan, Hui Huang, Jia Yang, Ziyu Tan, Libo Hui, Yue Liu, Hang Pan, Yue Qu, Zhaofeng Chen, Liwen Tan, Lijuan Yu, Hongcheng Shi, Li Huo, Yanjun Zhang, Xin Tang, Shaoxiang Zhang, Changjian Liu
In recent years, there has been increasing demand for personalized anatomy modelling for medical and industrial applications, such as ergonomics device development, clinical radiological exposure simulation, biomechanics analysis, and 3D animation character design. In this study, we constructed deformable torso phantoms that can be deformed to match the personal anatomy of Chinese male and female adults. The phantoms were created based on a training set of 79 trunk computed tomography (CT) images (41 males and 38 females) from normal Chinese subjects...
April 16, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29662506/patterns-of-in-hospital-mortality-and-bleeding-complications-following-pci-for-very-elderly-patients-insights-from-the-dartmouth-dynamic-registry
#19
Shawn X Li, Hannah I Chaudry, Jiyong Lee, Theodore B Curran, Vishesh Kumar, Kendrew K Wong, Bruce W Andrus, James T DeVries
Background: Very elderly patients (age ≥ 85 years) are a rapidly increasing segment of the population. As a group, they experience high rates of in-hospital mortality and bleeding complications following percutaneous coronary intervention (PCI). However, the relationship between bleeding and mortality in the very elderly is unknown. Methods: Retrospective review was performed on 17,378 consecutive PCI procedures from 2000 to 2015 at Dartmouth-Hitchcock Medical Center...
February 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29661575/outcomes-of-laparoscopic-resection-of-meckel-s-diverticulum-are-equivalent-to-open-laparotomy
#20
Brian Ezekian, Harold J Leraas, Brian R Englum, Brian F Gilmore, Christopher Reed, Tamara N Fitzgerald, Henry E Rice, Elisabeth T Tracy
PURPOSE: Meckel's diverticulum (MD) is a common congenital anomaly caused by failure of involution of the omphalomesenteric duct. Enthusiasm for minimally invasive surgery (MIS) in children has burgeoned as technologies have advanced, but the outcomes of laparoscopic resection in comparison to open laparotomy for MD remain poorly defined. We queried a large national database to compare current practice patterns and clinical outcomes between surgical approaches for MD in the pediatric population...
March 15, 2018: Journal of Pediatric Surgery
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