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https://www.readbyqxmd.com/read/28532774/genotype-positive-long-qt-syndrome-in-patients-with-coexisting-congenital-heart-disease
#1
Mohammed A Ebrahim, Matthew R Williams, Suzanne Shepard, James C Perry
Congenital long QT syndrome (LQTS) is characterized by QT prolongation with predisposition to life-threatening arrhythmia. There have been sporadic reports of LQTS coexisting with more common forms of congenital heart disease (CHD). However, the diagnosis of LQTS when CHD is present may be confounded by several common variables including postoperative electromechanical factors predisposing to ventricular arrhythmia, intrinsic, and postoperative QRS abnormalities. This report documents a single-center experience with patients who have both genetically confirmed LQTS and CHD to examine their modes of presentation and factors associated with making the diagnosis of LQTS in this patient population, as well as potential confounding variables that may mask or delay both LQTS diagnosis and initiation of therapy...
April 27, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28530079/-kidney-diseases-in-north-israel-according-to-kidney-biopsies-bnai-zion-medical-center-14-years-experience
#2
Shimon Storch, Nadav Willner, Aurora Toubi, Simona Croitoru, Vladimir Wolfson, Ibrahim Matar, Elinor Grushka, Majed Odeh, Efrat Wolfovits, Elad Schiff, Yitzhak Rosner, Elias Toubi, Aharon Kessel, Ofer Ben Izhak, Boaz Moskovitz, Ofer Nativ
INTRODUCTION: Little is known about the prevalence of kidney diseases according to renal biopsy in Israel. Since updated literature worldwide emphasizes changing etiologies of chronic kidney disease, it is crucial to research and define the epidemiology and pathology of kidney disease in Israel. Hereby, we introduce an original review of the prevalence of kidney diseases in our study population, which we believe reflects the prevalence of kidney diseases in the population of Israel. AIMS: To investigate the prevalence of kidney diseases diagnosed by renal biopsy, according to age, gender, race and clinical symptoms...
September 2016: Harefuah
https://www.readbyqxmd.com/read/28529092/correlation-and-prognostic-role-of-neutrophil-to-lymphocyte-ratio-and-syntax-score-in-patients-with-acute-myocardial-infarction-treated-with-percutaneous-coronary-intervention-a-six-year-experience
#3
Marco Zuin, Gianluca Rigatelli, Claudio Picariello, Fabio dell'Avvocata, Lina Marcantoni, Gianni Pastore, Mauro Carraro, Aravinda Nanjundappa, Giuseppe Faggian, Loris Roncon
BACKGROUND/PURPOSE: The neutrophil/lymphocyte ratio (NLR) has been proposed as a prognostic marker in acute myocardial infarction (AMI). The aim of our study is to demonstrates the correlation between SYNTAX score (SXs) and NLR and its association with 1-year cardiovascular (CV) mortality in patients with ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation myocardial infarction (NSTEMI) treated with percutaneous coronary intervention (PCI). METHODS/MATERIALS: Over 6 consecutive years, (1st January 2010 and 1st January 2016) 6560 patients (4841 males and 1719 females, mean age 64...
May 12, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28528904/spatially-periodic-activation-patterns-of-retrosplenial-cortex-encode-route-sub-spaces-and-distance-traveled
#4
Andrew S Alexander, Douglas A Nitz
Traversal of a complicated route is often facilitated by considering it as a set of related sub-spaces. Such compartmentalization processes could occur within retrosplenial cortex, a structure whose neurons simultaneously encode position within routes and other spatial coordinate systems. Here, retrosplenial cortex neurons were recorded as rats traversed a track having recurrent structure at multiple scales. Consistent with a major role in compartmentalization of complex routes, individual retrosplenial cortex (RSC) neurons exhibited periodic activation patterns that repeated across route segments having the same shape...
May 17, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28528380/the-rat-corticospinal-system-is-functionally-and-anatomically-segregated
#5
Rafael Olivares-Moreno, Yunuen Moreno-Lopez, Luis Concha, Guadalupe Martínez-Lorenzana, Miguel Condés-Lara, Matilde Cordero-Erausquin, Gerardo Rojas-Piloni
The descending corticospinal (CS) projection has been considered a key element for motor control, which results from direct and indirect modulation of spinal cord pre-motor interneurons in the intermediate gray matter of the spinal cord, which, in turn, influences motoneurons in the ventral horn. The CS tract (CST) is also involved in a selective and complex modulation of sensory information in the dorsal horn. However, little is known about the spinal network engaged by the CST and the organization of CS projections that may encode different cortical outputs to the spinal cord...
May 20, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28526546/acute-coronary-syndromes-in-the-very-elderly-short-term-prognostic-performance-of-the-syntax-score
#6
Laurent Faroux, Sophie Tassan-Mangina, Benoit Herce, Pierre Nazeyrollas, Karine Bauley, Damien Metz
Acute coronary syndromes (ACS) frequently occur in elderly subjects. The high mortality associated with ACS in this population justifies the identification of factors related to poor prognosis. We aimed to evaluate the short-term prognostic performance of the SYNTAX score in a population of patients aged 85years or more presenting ACS and undergoing coronary angiography. Secondary objectives were to identify factors related to length of stay and potential markers of in-hospital death. We performed a retrospective, single-centre prognostic study including patients aged 85years or more who underwent coronary angiography for ACS over a 4year period...
May 12, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28524640/segmental-colonic-dilation-is-associated-with-premature-termination-of-high-amplitude-propagating-contractions-in-children-with-intractable-functional-constipation
#7
I J N Koppen, B P Thompson, E J Ambeba, V A Lane, D G Bates, P C Minneci, K J Deans, M A Levitt, R J Wood, M A Benninga, C Di Lorenzo, D Yacob
BACKGROUND: Colonic dilation is common in children with intractable functional constipation (FC). Our aim was to describe the association between segmental colonic dilation and colonic dysmotility in children with FC. METHODS: We performed a retrospective study on 30 children with intractable FC (according to the Rome III criteria) who had undergone colonic manometry and contrast enema within a 12-month time period. Colonic diameter was measured at 5 cm intervals from the anal verge up to the splenic flexure...
May 19, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28522735/d3-receptors-regulate-excitability-in-a-unique-class-of-prefrontal-pyramidal-cell
#8
Rebecca L Clarkson, Alayna T Liptak, Steven M Gee, Vikaas S Sohal, Kevin J Bender
The D3 dopamine receptor, a member of the Gi-coupled D2-family of dopamine receptors, is expressed throughout limbic circuits affected in neuropsychiatric disorders, including prefrontal cortex. These receptors are important for prefrontal executive function, as pharmacological and genetic manipulations that affect prefrontal D3 receptors alter anxiety, social interaction, and reversal learning. And yet, the mechanisms by which D3 receptors regulate prefrontal circuits, and whether D3 receptors regulate specific prefrontal subnetworks, remain unknown...
May 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28521831/the-sitless-project-exercise-referral-schemes-enhanced-by-self-management-strategies-to-battle-sedentary-behaviour-in-older-adults-study-protocol-for-a-randomised-controlled-trial
#9
Maria Giné-Garriga, Laura Coll-Planas, Míriam Guerra, Àlex Domingo, Marta Roqué, Paolo Caserotti, Michael Denkinger, Dietrich Rothenbacher, Mark A Tully, Frank Kee, Emma McIntosh, Carme Martín-Borràs, Guillermo R Oviedo, Javier Jerez-Roig, Marta Santiago, Oriol Sansano, Guillermo Varela, Mathias Skjødt, Katharina Wirth, Dhayana Dallmeier, Jochen Klenk, Jason J Wilson, Nicole E Blackburn, Manuela Deidda, Guillaume Lefebvre, Denise González, Antoni Salvà
BACKGROUND: Older adults are the fastest growing segment of the world's population. Recent evidence indicates that excessive sitting time is harmful to health, independent of meeting the recommended moderate to vigorous physical activity (PA) guidelines. The SITLESS project aims to determine whether exercise referral schemes (ERS) can be enhanced by self-management strategies (SMSs) to reduce sedentary behaviour (SB), increase PA and improve health, quality of life and function in the long term, as well as psychosocial outcomes in community-dwelling older European citizens from four countries, within a three-armed pragmatic randomised controlled trial, compared with ERS alone and also with general recommendations about PA...
May 18, 2017: Trials
https://www.readbyqxmd.com/read/28515774/complexity-and-algorithms-for-copy-number-evolution-problems
#10
Mohammed El-Kebir, Benjamin J Raphael, Ron Shamir, Roded Sharan, Simone Zaccaria, Meirav Zehavi, Ron Zeira
BACKGROUND: Cancer is an evolutionary process characterized by the accumulation of somatic mutations in a population of cells that form a tumor. One frequent type of mutations is copy number aberrations, which alter the number of copies of genomic regions. The number of copies of each position along a chromosome constitutes the chromosome's copy-number profile. Understanding how such profiles evolve in cancer can assist in both diagnosis and prognosis. RESULTS: We model the evolution of a tumor by segmental deletions and amplifications, and gauge distance from profile [Formula: see text] to [Formula: see text] by the minimum number of events needed to transform [Formula: see text] into [Formula: see text]...
2017: Algorithms for Molecular Biology: AMB
https://www.readbyqxmd.com/read/28512582/factors-affecting-utilization-of-voluntary-hiv-counseling-and-testing-services-among-teachers-in-awi-zone-northwest-ethiopia
#11
Woudneh Gereme Desta, Mulusew Alemneh Sinishaw, Kelemu Dessie Bizuneh
HIV/AIDS affects the basic educational sector which is the most productive segment of the population and vital to the creation of human capital. The loss of skilled and experienced teachers due to the problem is increasingly compromising the provision of quality education in most African countries. The study was proposed to determine the magnitude of VCT utilization and assess contributing factors that affect VCT service utilization among secondary school teachers in Awi Zone. A cross-sectional study design was conducted among 588 participants in 2014...
2017: AIDS Research and Treatment
https://www.readbyqxmd.com/read/28512097/glutathionylation-of-yersinia-pestis-lcrv-and-its-effects-on-plague-pathogenesis
#12
Anthony Mitchell, Christina Tam, Derek Elli, Thomas Charlton, Patrick Osei-Owusu, Farbod Fazlollahi, Kym F Faull, Olaf Schneewind
Glutathionylation, the formation of reversible mixed disulfides between glutathione and protein cysteine residues, is a posttranslational modification previously observed for intracellular proteins of bacteria. Here we show that Yersinia pestis LcrV, a secreted protein capping the type III secretion machine, is glutathionylated at Cys(273) and that this modification promotes association with host ribosomal protein S3 (RPS3), moderates Y. pestis type III effector transport and killing of macrophages, and enhances bubonic plague pathogenesis in mice and rats...
May 16, 2017: MBio
https://www.readbyqxmd.com/read/28511735/addenbrooke-s-cognitive-examination-revised-normative-and-accuracy-data-for-seniors-with-heterogeneous-educational-level-in-brazil
#13
Karolina G César, Mônica S Yassuda, Fabio H G Porto, Sonia M D Brucki, Ricardo Nitrini
BACKGROUND: Several cognitive tools have been developed aiming to diagnose dementia. The cognitive battery Addenbrooke's Cognitive Examination - Revised (ACE-R) has been used to detect cognitive impairment; however, there are few studies including samples with low education. The aim of the study was to provide ACE-R norms for seniors within a lower education, including illiterates. An additional aim was to examine the accuracy of the ACE-R to detect dementia and cognitive impairment no dementia (CIND)...
May 17, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28511677/a-strategy-to-improve-phasing-of-whole-genome-sequenced-individuals-through-integration-of-familial-information-from-dense-genotype-panels
#14
Pierre Faux, Tom Druet
BACKGROUND: Haplotype reconstruction (phasing) is an essential step in many applications, including imputation and genomic selection. The best phasing methods rely on both familial and linkage disequilibrium (LD) information. With whole-genome sequence (WGS) data, relatively small samples of reference individuals are generally sequenced due to prohibitive sequencing costs, thus only a limited amount of familial information is available. However, reference individuals have many relatives that have been genotyped (at lower density)...
May 16, 2017: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/28511408/estimation-of-total-length-of-femur-from-its-proximal-and-distal-segmental-measurements-of-disarticulated-femur-bones-of-nepalese-population-using-regression-equation-method
#15
Laxman Khanal, Sandip Shah, Sarun Koirala
INTRODUCTION: Length of long bones is taken as an important contributor for estimating one of the four elements of forensic anthropology i.e., stature of the individual. Since physical characteristics of the individual differ among different groups of population, population specific studies are needed for estimating the total length of femur from its segment measurements. AIM: Since femur is not always recovered intact in forensic cases, it was the aim of this study to derive regression equations from measurements of proximal and distal fragments in Nepalese population...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28508991/digital-stethoscopes-compared-to-standard-auscultation-for-detecting-abnormal-paediatric-breath-sounds
#16
Ajay C Kevat, Anaath Kalirajah, Robert Roseby
Our study aimed to objectively describe the audiological characteristics of wheeze and crackles in children by using digital stethoscope (DS) auscultation, as well as assess concordance between standard auscultation and two different DS devices in their ability to detect pathological breath sounds. Twenty children were auscultated by a paediatric consultant doctor and digitally recorded using the Littman™ 3200 Digital Electronic Stethoscope and a Clinicloud™ DS with smart device. Using spectrographic analysis, we found those with clinically described wheeze had prominent periodic waveform segments spanning expiration for a period of 0...
May 16, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28508570/a-new-transcript-in-the-tcrb-locus-unveils-the-human-ortholog-of-the-mouse-pre-d%C3%A3-1-promoter
#17
Bernard Lethé, Sylvia Snauwaert, Orian Bricard, David Schröder, Tiphanie Gomard, Gérald Hames, Catherine Muller, Christophe Lurquin, Emilie Gauthy, Ahmed Essaghir, Bart Vandekerckhove, Pierre G Coulie
INTRODUCTION: While most transcripts arising from the human T Cell Receptor locus reflect fully rearranged genes, several germline transcripts have been identified. We describe a new germline transcript arising from the human TCRB locus. METHODS: cDNA sequencing, promoter, and gene expression analyses were used to characterize the new transcript. RESULTS: The new germline transcript encoded by the human TCRB locus consists of a new exon of 103 bp, which we named TRBX1 (X1), spliced with the first exon of gene segments Cß1 or Cß2...
May 15, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28508221/rapid-reverse-genetics-systems-for-rhabdoviruses-from-forward-to-reverse-and-back-again
#18
Tobias Nolden, Stefan Finke
Methods to recover recombinant negative strand RNA viruses (rNSVs) from cloned cDNAs have been significantly improved in more than two decades of NSV reverse genetics . In particular, for non-segmented negative strand RNA viruses (NNSVs ) like rhabdoviruses , time-consuming generation of reverse genetics systems by stitching PCR subfragments of genomic rhabdovirus cDNAs using ligase-based conventional cloning approaches limited the number of available recombinant virus cDNA clones. As genetic variability is considered an intrinsic feature of RNA viruses, it is thus reasonable to conclude that reverse genetics approaches to investigate natural virus functions and pathogenesis require improved systems that reflect the complexity of naturally occurring wild-type viruses, and that largely exclude adaption to cell culture conditions...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28507757/risk-of-post-colonoscopy-colorectal-cancer-due-to-incomplete-adenoma-resection-a-nationwide-population-based-cohort-study
#19
Tim Dg Belderbos, Hendrikus Jm Pullens, Max Leenders, Marguerite Ei Schipper, Peter D Siersema, Martijn Gh van Oijen
BACKGROUND: Most post-colonoscopy colorectal cancers (PC-CRCs) are thought to develop from missed or incompletely resected adenomas. AIMS: We aimed to assess the incidence rate of PC-CRC overall and per colorectal segment, as a proxy for PC-CRC due to incomplete adenoma resection, and to identify adenoma characteristics associated with these PC-CRCs. METHODS: We performed a nationwide, population-based cohort study, including all patients with a first colorectal adenoma between 2000-2010 in the Dutch Pathology Registry (PALGA)...
April 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28505173/continental-divide-predicting-climate-mediated-fragmentation-and-biodiversity-loss-in-the-boreal-forest
#20
Dennis L Murray, Michael J L Peers, Yasmine N Majchrzak, Morgan Wehtje, Catarina Ferreira, Rob S A Pickles, Jeffrey R Row, Daniel H Thornton
Climate change threatens natural landscapes through shifting distribution and abundance of species and attendant change in the structure and function of ecosystems. However, it remains unclear how climate-mediated variation in species' environmental niche space may lead to large-scale fragmentation of species distributions, altered meta-population dynamics and gene flow, and disrupted ecosystem integrity. Such change may be especially relevant when species distributions are restricted either spatially or to a narrow environmental niche, or when environments are rapidly changing...
2017: PloS One
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