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https://www.readbyqxmd.com/read/29457844/effect-of-type-d-personality-on-smoking-status-and-their-combined-impact-on-outcome-after-acute-myocardial-infarction
#1
Egidio Imbalzano, Marco Vatrano, Sebastiano Quartuccio, Roberto Ceravolo, Vincenzo Antonio Ciconte, Paola Rotella, Renato Pardeo, Giovanni Trapani, Pasquale De Fazio, Cristina Segura-Garcia, Rossella Costantino, Antonino Saitta, Giuseppe Mandraffino
BACKGROUND: Smoking cessation is correlated with several psychological, social, biological, and pharmacological aspects. The combined tendency to experience negative emotions and to inhibit the expression of these emotions is indicated as "type D personality," an independent risk marker for clinical outcome in cardiac disease. Despite this effect of type D personality on cardiovascular disease, it is still unclear whether this personality trait may influence smoking cessation after a myocardial infarction...
February 19, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29456219/descriptive-analysis-of-glomerulonephritis-by-histological-type-and-their-progression-among-adults-in-a-tertiary-care-center-in-sri-lanka
#2
Kawmadi W Gunawardena, Eranga S Wijewickrama, Carukshi Arambepola, Rushika D Lanerolle
Prevalence of different glomerulonephritides and their clinical course vary geographically. Our objectives are to assess the prevalence of different histological types of glomerulonephritis (GN) based on the light microscopic histology and to assess their progression according to histological type. A retrospective cross-sectional study was carried out among adult patients (>18 years) with a histological diagnosis of GN at the University Professorial Unit over a period of six months. Information including demographic data, renal biopsy findings, and progression of the disease through serum creatinine (SCr) level were collected through existing clinic records of consenting patients...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456184/quantified-f-actin-morphology-is-predictive-of-phagocytic-capacity-of-stem-cell-derived-retinal-pigment-epithelium
#3
Claudia Müller, Carol Charniga, Sally Temple, Silvia C Finnemann
With stem cell-derived retinal pigment epithelial (RPE) replacement therapies in clinical testing, establishing potency of RPE prior to transplantation is imperative. Phagocytosis of photoreceptor outer segment fragments (POS) is a key indicator of RPE functionality. Comparing RPE derived from different donor human adult RPE stem cell lines, we found that cells were either high-phagocytic or low-phagocytic despite sharing phagocytic receptors and ligands, junctional ZO-1, and lack of epithelial-mesenchymal transition...
February 9, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29455171/visual-motor-integration-and-fine-motor-skills-at-6%C3%A2-years-of-age-and-associations-with-neonatal-brain-volumes-in-children-born-extremely-preterm-in-sweden-a-population-based-cohort-study
#4
Jenny Bolk, Nelly Padilla, Lea Forsman, Lina Broström, Kerstin Hellgren, Ulrika Åden
OBJECTIVES: This exploratory study aimed to investigate associations between neonatal brain volumes and visual-motor integration (VMI) and fine motor skills in children born extremely preterm (EPT) when they reached 6½ years of age. SETTING: Prospective population-based cohort study in Stockholm, Sweden, during 3 years. PARTICIPANTS: All children born before gestational age, 27 weeks, during 2004-2007 in Stockholm, without major morbidities and impairments, and who underwent MRI at term-equivalent age...
February 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29452692/prognostic-significance-of-complex-ventricular-arrhythmias-complicating-st-segment-elevation-myocardial-infarction
#5
Tomasz Podolecki, Radoslaw Lenarczyk, Jacek Kowalczyk, Ewa Jedrzejczyk-Patej, Piotr Chodor, Michal Mazurek, Pawel Francuz, Witold Streb, Katarzyna Mitrega, Zbigniew Kalarus
The aim of the study was to assess the clinical significance of complex ventricular arrhythmias (VAs) (sustained ventricular tachycardia [sVT] and ventricular fibrillation [VF]) in patients with ST-segment elevation myocardial infarction (STEMI) depending on timing of arrhythmia. We analyzed 4,363 consecutive patients with STEMI treated invasively between 2004 and 2014. The median follow-up was 69.6 months (range: 0 to 139.8 months). The study population was divided into 2 main groups; VA group encompassed 476 patients (10...
January 12, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29452689/measurements-of-lumen-areas-and-diameters-of-proximal-and-middle-coronary-artery-segments-in-subjects-without-coronary-atherosclerosis
#6
Jaroslaw Skowronski, Jerzy Pregowski, Gary S Mintz, Mariusz Kruk, Cezary Kepka, Pawel Tyczynski, Ilona Michalowska, Lukasz Kalinczuk, Maksymilian P Opolski, Michal Ciszewski, Rafal Wolny, Zbigniew Chmielak, Adam Witkowski
There are plenty of data on morphology and lumen dimensions of diseased coronary arteries. However, information on normal coronary vessel anatomy is scarce. We provided computed tomography angiography-derived reference values of lumen dimensions in proximal and middle coronary segments in a healthy population with respect to gender and vessel dominance. Consecutive 2,849 computed tomography angiography examinations were reviewed to identify 201 subjects (77 men, patient age 50 ± 13 years) whose coronary arteries were free from any sign of atherosclerosis (calcium score 0, no detectable plaque)...
February 2, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29449325/quantitative-flow-ratio-identifies-nonculprit-coronary-lesions-requiring-revascularization-in-patients-with-st-segment-elevation-myocardial-infarction-and-multivessel-disease
#7
Giosafat Spitaleri, Matteo Tebaldi, Simone Biscaglia, Jelmer Westra, Salvatore Brugaletta, Andrea Erriquez, Giulia Passarini, Alessandro Brieda, Antonio Maria Leone, Andrea Picchi, Alfonso Ielasi, Domenico Di Girolamo, Carlo Trani, Roberto Ferrari, Johan H C Reiber, Marco Valgimigli, Manel Sabatè, Gianluca Campo
BACKGROUND: The nonculprit lesion (NCL) management in ST-segment-elevation myocardial infarction patients with multivessel disease is debated. We sought to assess whether quantitative flow ratio (QFR), a noninvasive tool to identify potentially flow-limiting lesions, may be reliable in this scenario. METHODS AND RESULTS: The present proof-of-concept study is based on a 3-step process: (1) identification of the QFR reproducibility in NCLs assessment (cohort A, n=31); (2) prospective validation of QFR diagnostic accuracy in respect to fractional flow reserve (cohort B, n=45); and (3) investigation of long-term clinical outcomes of NCLs stratified according to QFR (cohort C, n=110)...
February 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29449277/modeling-early-postnatal-brain-growth-and-development-with-ct-changes-in-the-brain-radiodensity-histogram-from-birth-to-2-years
#8
K A Cauley, Y Hu, J Och, P J Yorks, S W Fielden
BACKGROUND AND PURPOSE: The majority of brain growth and development occur in the first 2 years of life. This study investigated these changes by analysis of the brain radiodensity histogram of head CT scans from the clinical population, 0-2 years of age. MATERIALS AND METHODS: One hundred twenty consecutive head CTs with normal findings meeting the inclusion criteria from children from birth to 2 years were retrospectively identified from 3 different CT scan platforms...
February 15, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29444506/the-impact-of-advanced-age-on-driving-safety-in-adults-with-medical-conditions
#9
Sanghee Moon, Maud Ranchet, Abiodun Emmanuel Akinwuntan, Mark Tant, David Brian Carr, Mukaila Ajiboye Raji, Hannes Devos
BACKGROUND: Adults aged 85 and older, often referred to as the oldest-old, are the fastest-growing segment of the population. The rapidly increasing number of older adults with chronic and multiple medical conditions poses challenges regarding their driving safety. OBJECTIVE: To investigate the effect of advanced age on driving safety in drivers with medical conditions. METHODS: We categorized 3,425 drivers with preexisting medical conditions into four age groups: middle-aged (55-64 years, n = 1,386), young-old (65-74 years, n = 1,013), old-old (75-84 years, n = 803), or oldest-old (85 years and older, n = 223)...
February 14, 2018: Gerontology
https://www.readbyqxmd.com/read/29441692/a-conservation-planning-tool-for-greater-sage-grouse-using-indices-of-species-distribution-resilience-and-resistance
#10
Mark A Ricca, Peter S Coates, K Benjamin Gustafson, Brianne E Brussee, Jeanne C Chambers, Shawn P Espinosa, Scott C Gardner, Sherri Lisius, Pilar Ziegler, David J Delehanty, Michael L Casazza
Managers require quantitative yet tractable tools that can identify areas for restoration yielding effective benefits for targeted wildlife species and the ecosystems they inhabit. As a contemporary example of high national significance for conservation, the persistence of greater sage-grouse (Centrocercus urophasianus, hereafter 'sage-grouse') in the Great Basin ecoregion is compromised, in part, by strongly interacting stressors of conifer encroachment, annual grass invasion, and larger and more frequent wildfires occurring in sagebrush ecosystems...
February 14, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29440869/exfoliation-syndrome-in-northern-nigeria
#11
Ugbede Idakwo, Olusola Olawoye, Benedictus Gk Ajayi, Robert Ritch
Purpose: To estimate the frequency of exfoliation syndrome (XFS) and its association with ocular diseases in Northern Nigeria. Materials and methods: Consecutive patients who presented to the outpatient department of ECWA Eye Hospital Kano from February 2015 to May 2015 were included in the study. Each patient had a complete ophthalmic examination. The anterior segment examination included tonometry, gonioscopy, and detailed slit-lamp examination to assess for the presence or absence of exfoliation material, inflammatory cells, and other abnormal findings...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29439700/ocular-dimensions-of-the-chinese-adolescents-with-keratoconus
#12
Weijun Jian, Yang Shen, Yingjun Chen, Mi Tian, Xingtao Zhou
BACKGROUND: Adolescent KC is a special segment of the general KC population because an adolescents's eyes are still susceptible to blurred vision and optical defocus during the sensitive period of ocular and visual development. In the present study, we evaluated the ocular dimensions of 53 KC adolescents. METHODS: One hundred and six KC eyes of 53 (42 boys and 11 girls) KC adolescents (age 15.5 ± 1.7 years, range 11 to 18) were involved in this retrospective study...
February 13, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29439666/prevalence-and-causes-of-low-vision-and-blindness-in-an-elderly-population-in-nepal-the-bhaktapur-retina-study
#13
Raba Thapa, Sanyam Bajimaya, Govinda Paudyal, Shankar Khanal, Stevie Tan, Suman S Thapa, G H M B van Rens
BACKGROUND: This study aims to explore the prevalence and causes of low vision and blindness focused on retinal disease in a population above 60 years in Nepal. METHODS: Two thousand one hundred subjects were enrolled in a population-based cross-sectional study. History, presenting and best corrected visual acuity after subjective refraction, anterior and posterior segment examinations was obtained in detail. RESULTS: Among the total subjects, 1860 (88...
February 13, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29439076/cohort-profile-centenari-a-trieste-cat-a-study-of-the-health-status-of-centenarians-in-a-small-defined-area-of-italy
#14
Mauro Tettamanti, Gabriella Marcon
PURPOSE: Centenarians, a segment of the population which some 50 years ago comprised only a few individuals, now count thousands in many countries, and demographic projections forecast that this growth will continue. The study of this new population will give us new information on extreme longevity and help prepare for their health and social needs. The aim of the Centenari a Trieste study is to describe the health and health service use by centenarians, with specific focus on cognitive status...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29438826/morphometric-analyses-of-small-accessory-liver-lobes-using-radiological-imaging
#15
Kumi Ozaki, Jun Yoshikawa, Toru Yamamoto
AIM: To investigate the prevalence and morphometric characteristics of small accessory liver lobes using computed tomography (CT) and magnetic resonance (MR) images. MATERIAL AND METHODS: The study population comprised 3269 patients (1671 men and 1598 women; mean age, 67.1 ± 15.2 years) who had undergone abdominal CT examination. Small accessory liver lobes were identified after verification of their continuity with the liver parenchyma on CT images. Their imaging characteristics were analyzed and presented...
February 6, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29436479/the-ontogeny-of-a-neutrophil-mechanisms-of-granulopoiesis-and-homeostasis
#16
REVIEW
Shelley M Lawrence, Ross Corriden, Victor Nizet
Comprising the majority of leukocytes in humans, neutrophils are the first immune cells to respond to inflammatory or infectious etiologies and are crucial participants in the proper functioning of both innate and adaptive immune responses. From their initial appearance in the liver, thymus, and spleen at around the eighth week of human gestation to their generation in large numbers in the bone marrow at the end of term gestation, the differentiation of the pluripotent hematopoietic stem cell into a mature, segmented neutrophil is a highly controlled process where the transcriptional regulators C/EBP-α and C/EBP-ε play a vital role...
June 2018: Microbiology and Molecular Biology Reviews: MMBR
https://www.readbyqxmd.com/read/29435140/triplications-of-human-chromosome-21-orthologous-regions-in-mice-result-in-expansion-of-megakaryocyte-erythroid-progenitors-and-reduction-of-granulocyte-macrophage-progenitors
#17
Chunhong Liu, Tao Yu, Zhuo Xing, Xiaoling Jiang, Yichen Li, Annie Pao, Justin Mu, Paul K Wallace, George Stoica, Andrei V Bakin, Y Eugene Yu
Individuals with Down syndrome (DS) frequently have hematopoietic abnormalities, including transient myeloproliferative disorder and acute megakaryoblastic leukemia which are often accompanied by acquired GATA1 mutations that produce a truncated protein, GATA1s. The mouse has been used for modeling DS based on the syntenic conservation between human chromosome 21 (Hsa21) and three regions in the mouse genome located on mouse chromosome 10 (Mmu10), Mmu16 and Mmu17. To assess the impact of the dosage increase of Hsa21 gene orthologs on the hematopoietic system, we characterized the related phenotype in the Dp(10)1Yey/+;Dp(16)1Yey/+;Dp(17)1Yey/+ model which carries duplications spanning the entire Hsa21 orthologous regions on Mmu10, Mmu16 and Mmu17, and the Dp(10)1Yey /+; Dp(16)1Yey /+; Dp(17)1Yey/+ ; Gata1 Yeym2 model which carries a Gata1s mutation we engineered...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29431253/researching-the-decline-in-adolescent-drinking-the-need-for-a-global-and-generational-approach
#18
Amy Pennay, John Holmes, Jukka Törrönen, Michael Livingston, Ludwig Kraus, Robin Room
Adolescent alcohol consumption has been in decline across many high-income countries since the early to mid-2000s. This is a significant public health trend, with few documented examples from history where such a global downward shift in alcohol consumption has occurred primarily among the adolescent segment of the population. In this commentary we describe the nature and breadth of the trend; reflect on the environmental, social and policy factors that have been proffered; and argue that to adequately understand and support the maintenance of these trends, three important methodological considerations are needed for future research...
February 12, 2018: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29431033/hotspots-of-road-traffic-crashes-in-a-redeveloping-area-of-shanghai
#19
Xiuqin Chen, Limei Huang, Dajun Dai, Meiying Zhu, Kezhi Jin
To identify high-risk locations (hotspots) of road traffic crashes (RTC) in a redeveloping area of Shanghai, for formulating relevant countermeasures in similar areas. After geocoding the crash locations on electronic map, assessment of spatial clustering of accidents and hotspots spatial densities was conducted following Moran's I method, the kernel density estimation, the Ripley's K-function and the network-based kernel density estimation (NKDE). A total of 21,679 RTC incidents resulting in 24,147 victims were recorded from 2010 to 2012...
February 12, 2018: International Journal of Injury Control and Safety Promotion
https://www.readbyqxmd.com/read/29430560/epilepsy-is-associated-with-ventricular-alterations-following-convulsive-status-epilepticus-in-children
#20
Wail Ali, Beth A Bubolz, Linh Nguyen, Danny Castro, Jorge Coss-Bu, Michael M Quach, Curtis E Kennedy, Anne E Anderson, Yi-Chen Lai
Objective: Convulsive status epilepticus can exert profound cardiovascular effects in adults including ventricular depolarization-repolarization abnormalities. Whether status epilepticus adversely affects ventricular electrical properties in children is less understood. Therefore, we sought to characterize ventricular alterations and the associated clinical factors in children following convulsive status epilepticus. Methods: We conducted a 2-year retrospective, case-control study...
December 2017: Epilepsia Open
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