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https://www.readbyqxmd.com/read/28857651/gray-matter-structural-networks-are-associated-with-cardiovascular-risk-factors-in-healthy-older-adults
#1
Shahrzad Kharabian Masouleh, Frauke Beyer, Leonie Lampe, Markus Loeffler, Tobias Luck, Steffi G Riedel-Heller, Matthias L Schroeter, Michael Stumvoll, Arno Villringer, A Veronica Witte
While recent 'big data' analyses discovered structural brain networks that alter with age and relate to cognitive decline, identifying modifiable factors that prevent these changes remains a major challenge. We therefore aimed to determine the effects of common cardiovascular risk factors on vulnerable gray matter (GM) networks in a large and well-characterized population-based cohort. In 616 healthy elderly (258 women, 60-80 years) of the LIFE-Adult-Study, we assessed the effects of obesity, smoking, blood pressure, markers of glucose and lipid metabolism as well as physical activity on major GM-networks derived using linked independent component analysis...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28823105/understanding-peripartum-depression-through-neuroimaging-a-review-of-structural-and-functional-connectivity-and-molecular-imaging-research
#2
REVIEW
Christy Duan, Jessica Cosgrove, Kristina M Deligiannidis
PURPOSE OF REVIEW: Imaging research has sought to uncover brain structure, function, and metabolism in women with postpartum depression (PPD) as little is known about its underlying pathophysiology. This review discusses the imaging modalities used to date to evaluate postpartum depression and highlights recent findings. RECENT FINDINGS: Altered functional connectivity and activity changes in brain areas implicated in executive functioning and emotion and reward processing have been identified in PPD...
August 19, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28633986/gray-matter-abnormalities-in-non-comorbid-medication-naive-patients-with-major-depressive-disorder-or-social-anxiety-disorder
#3
Youjin Zhao, Lizhou Chen, Wenjing Zhang, Yuan Xiao, Chandan Shah, Hongru Zhu, Minlan Yuan, Huaiqiang Sun, Qiang Yue, Zhiyun Jia, Wei Zhang, Weihong Kuang, Qiyong Gong, Su Lui
BACKGROUND: An overlap of clinical symptoms between major depressive disorder (MDD) and social anxiety disorder (SAD) suggests that the two disorders exhibit similar brain mechanisms. However, few studies have directly compared the brain structures of the two disorders. The aim of this study was to assess the gray matter volume (GMV) and cortical thickness alterations between non-comorbid medication-naive MDD patients and SAD patients. METHODS: High-resolution T1-weighted images were acquired from 37 non-comorbid MDD patients, 24 non-comorbid SAD patients and 41 healthy controls (HCs)...
July 2017: EBioMedicine
https://www.readbyqxmd.com/read/28588470/examining-brain-morphometry-associated-with-self-esteem-in-young-adults-using-multilevel-roi-features-based-classification-method
#4
Bo Peng, Jieru Lu, Aditya Saxena, Zhiyong Zhou, Tao Zhang, Suhong Wang, Yakang Dai
Purpose: This study is to exam self-esteem related brain morphometry on brain magnetic resonance (MR) images using multilevel-features-based classification method. Method: The multilevel region of interest (ROI) features consist of two types of features: (i) ROI features, which include gray matter volume, white matter volume, cerebrospinal fluid volume, cortical thickness, and cortical surface area, and (ii) similarity features, which are based on similarity calculation of cortical thickness between ROIs. For each feature type, a hybrid feature selection method, comprising of filter-based and wrapper-based algorithms, is used to select the most discriminating features...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28328939/multimodal-mr-imaging-reveals-large-scale-structural-and-functional-connectivity-changes-in-profound-early-blindness
#5
Corinna M Bauer, Gabriella V Hirsch, Lauren Zajac, Bang-Bon Koo, Olivier Collignon, Lotfi B Merabet
In the setting of profound ocular blindness, numerous lines of evidence demonstrate the existence of dramatic anatomical and functional changes within the brain. However, previous studies based on a variety of distinct measures have often provided inconsistent findings. To help reconcile this issue, we used a multimodal magnetic resonance (MR)-based imaging approach to provide complementary structural and functional information regarding this neuroplastic reorganization. This included gray matter structural morphometry, high angular resolution diffusion imaging (HARDI) of white matter connectivity and integrity, and resting state functional connectivity MRI (rsfcMRI) analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28324681/morphometric-mri-features-are-associated-with-surgical-outcome-in-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#6
Maria Teresa Fernandes Castilho Garcia, Larissa Botelho Gaça, Gabriel Barbosa Sandim, Idaiane Batista Assunção Leme, Henrique Carrete, Ricardo Silva Centeno, João Ricardo Sato, Elza Márcia Targas Yacubian
PURPOSE: Corticoamygdalohippocampectomy (CAH) improves seizure control, quality of life, and decreases mortality for refractory mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). One-third of patients continue having seizures, and it is pivotal to determine structural abnormalities that might influence the postoperative outcome. Studies indicate that nonhippocampal regions may play a role in the epileptogenic network in MTLE-HS and could generate seizures postoperatively...
March 1, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28259799/gray-and-white-matter-correlates-of-the-big-five-personality-traits
#7
Jesús Privado, Francisco J Román, Carlota Saénz-Urturi, Miguel Burgaleta, Roberto Colom
Personality neuroscience defines the scientific study of the neurobiological basis of personality. This field assumes that individual differences in personality traits are related with structural and functional variations of the human brain. Gray and white matters are structural properties considered separately in previous research. Available findings in this regard are largely disparate. Here we analyze the relationships between gray matter (cortical thickness (CT), cortical surface area (CSA), and cortical volume) and integrity scores obtained after several white matter tracts connecting different brain regions, with individual differences in the personality traits comprised by the Five-Factor Model (extraversion, agreeableness, conscientiousness, neuroticism, and openness to experience)...
May 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/28239524/pattern-of-gray-matter-volumes-related-to-retinal-thickness-and-its-association-with-cognitive-function-in-relapsing-remitting-ms
#8
Jan-Patrick Stellmann, Hanife Cetin, Kim Lea Young, Sibylle Hodecker, Jana Pöttgen, Diana Bittersohl, Andrea Hassenstein, Timm Oberwahrenbrock, Christoph Heesen, Susanne Siemonsen
BACKGROUND: Neurodegeneration in multiple sclerosis (MS) may be investigated in the visual system as optical coherence tomography (OCT) and magnetic resonance imaging (MRI) allows examining structural integrity in detail. The association between thickness of retinal layers and focal cortical volumes beyond the primary visual system has not been thoroughly investigated. OBJECTIVE: To investigate the association between focal cortical volume and thickness of retinal layers...
February 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28137552/small-vessel-disease-is-linked-to-disrupted-structural-network-covariance-in-alzheimer-s-disease
#9
Sean M Nestor, Bratislav Mišić, Joel Ramirez, Jiali Zhao, Simon J Graham, Nicolaas P L G Verhoeff, Donald T Stuss, Mario Masellis, Sandra E Black
INTRODUCTION: Cerebral small vessel disease (SVD) is thought to contribute to Alzheimer's disease (AD) through abnormalities in white matter networks. Gray matter (GM) hub covariance networks share only partial overlap with white matter connectivity, and their relationship with SVD has not been examined in AD. METHODS: We developed a multivariate analytical pipeline to elucidate the cortical GM thickness systems that covary with major network hubs and assessed whether SVD and neurodegenerative pathologic markers were associated with attenuated covariance network integrity in mild AD and normal elderly control subjects...
January 27, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28029706/morphological-brain-measures-of-cortico-limbic-inhibition-related-to-resilience
#10
Arpana Gupta, Aubrey Love, Lisa A Kilpatrick, Jennifer S Labus, Ravi Bhatt, Lin Chang, Kirsten Tillisch, Bruce Naliboff, Emeran A Mayer
Resilience is the ability to adequately adapt and respond to homeostatic perturbations. Although resilience has been associated with positive health outcomes, the neuro-biological basis of resilience is poorly understood. The aim of the study was to identify associations between regional brain morphology and trait resilience with a focus on resilience-related morphological differences in brain regions involved in cortico-limbic inhibition. The relationship between resilience and measures of affect were also investigated...
September 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27721203/the-segregated-connectome-of-late-life-depression-a-combined-cortical-thickness-and-structural-covariance-analysis
#11
Elijah Mak, Sean J Colloby, Alan Thomas, John T O'Brien
Late-life depression (LLD) has been associated with both generalized and focal neuroanatomical changes including gray matter atrophy and white matter abnormalities. However, previous literature has not been consistent and, in particular, its impact on the topology organization of brain networks remains to be established. In this multimodal study, we first examined cortical thickness, and applied graph theory to investigate structural covariance networks in LLD. Thirty-three subjects with LLD and 25 controls underwent T1-weighted, fluid-attenuated inversion recovery and clinical assessments...
December 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27503699/early-changes-of-brain-connectivity-in-primary-open-angle-glaucoma
#12
Paolo Frezzotti, Antonio Giorgio, Francesca Toto, Alessandro De Leucio, Nicola De Stefano
Our aim was to assess in primary open angle glaucoma (POAG), a major cause of irreversible blindness worldwide, whether diffuse brain changes recently shown in advanced stage can be detected since the early stage. We used multimodal magnetic resonance imaging (MRI) in 57 patients with the three POAG stages and in 29 age-matched normal controls (NC). Voxelwise statistics was performed with nonparametric permutation testing. Compared with NC, disrupted anatomical connectivity (AC) was found in the whole POAG group along the visual pathway and in nonvisual white matter tracts (P < 0...
December 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27226000/complementary-characteristics-of-correlation-patterns-in-morphometric-correlation-networks-of-cortical-thickness-surface-area-and-gray-matter-volume
#13
Jin-Ju Yang, Hunki Kwon, Jong-Min Lee
Morphometric correlation networks of cortical thickness, surface area, and gray matter volume have statistically different structural topology. However, there is no report directly describing their correlation patterns in view of interregional covariance. Here, we examined the characteristics of the correlation patterns in three morphometric networks of cortical thickness, surface area, and gray matter volume using a Venn diagram concept across 314 normal subjects. We found that over 60% of all nonoverlapping correlation patterns emerged with divergent unique patterns, while there were 10% of all common edges in ipsilateral and homotopic regions among the three morphometric correlation networks...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27158548/neuroimaging-the-brain-gut-axis-in-patients-with-irritable-bowel-syndrome
#14
Kristen R Weaver, LeeAnne B Sherwin, Brian Walitt, Gail D'Eramo Melkus, Wendy A Henderson
AIM: To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome (IBS). METHODS: A database search for relevant literature was conducted using PubMed, Scopus and Embase in February 2015. Date filters were applied from the year 2009 and onward, and studies were limited to those written in the English language and those performed upon human subjects. The initial search yielded 797 articles, out of which 38 were pulled for full text review and 27 were included for study analysis...
May 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27129440/reduced-frontal-cortex-thickness-and-cortical-volume-associated-with-pathological-narcissism
#15
Yu Mao, Na Sang, Yongchao Wang, Xin Hou, Hui Huang, Dongtao Wei, Jinfu Zhang, Jiang Qiu
Pathological narcissism is often characterized by arrogant behavior, a lack of empathy, and willingness to exploit other individuals. Generally, individuals with high levels of narcissism are more likely to suffer mental disorders. However, the brain structural basis of individual pathological narcissism trait among healthy people has not yet been investigated with surface-based morphometry. Thus, in this study, we investigated the relationship between cortical thickness (CT), cortical volume (CV), and individual pathological narcissism in a large healthy sample of 176 college students...
July 22, 2016: Neuroscience
https://www.readbyqxmd.com/read/27065831/connectomic-and-surface-based-morphometric-correlates-of-acute-mild-traumatic-brain-injury
#16
Patrizia Dall'Acqua, Sönke Johannes, Ladislav Mica, Hans-Peter Simmen, Richard Glaab, Javier Fandino, Markus Schwendinger, Christoph Meier, Erika J Ulbrich, Andreas Müller, Lutz Jäncke, Jürgen Hänggi
Reduced integrity of white matter (WM) pathways and subtle anomalies in gray matter (GM) morphology have been hypothesized as mechanisms in mild traumatic brain injury (mTBI). However, findings on structural brain changes in early stages after mTBI are inconsistent and findings related to early symptoms severity are rare. Fifty-one patients were assessed with multimodal neuroimaging and clinical methods exclusively within 7 days following mTBI and compared to 53 controls. Whole-brain connectivity based on diffusion tensor imaging was subjected to network-based statistics, whereas cortical surface area, thickness, and volume based on T1-weighted MRI scans were investigated using surface-based morphometric analysis...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27054487/brain-connectivity-in-normally-developing-children-and-adolescents
#17
Budhachandra S Khundrakpam, John D Lewis, Lu Zhao, François Chouinard-Decorte, Alan C Evans
The developing human brain undergoes an astonishing sequence of events that continuously shape the structural and functional brain connectivity. Distinct regional variations in the timelines of maturational events (synaptogenesis and synaptic pruning) occurring at the synaptic level are reflected in brain measures at macroscopic resolution (cortical thickness and gray matter density). Interestingly, the observed brain changes coincide with cognitive milestones suggesting that the changing scaffold of brain circuits may subserve cognitive development...
July 1, 2016: NeuroImage
https://www.readbyqxmd.com/read/26869873/structural-brain-network-characteristics-can-differentiate-cis-from-early-rrms
#18
Muthuraman Muthuraman, Vinzenz Fleischer, Pierre Kolber, Felix Luessi, Frauke Zipp, Sergiu Groppa
Focal demyelinated lesions, diffuse white matter (WM) damage, and gray matter (GM) atrophy influence directly the disease progression in patients with multiple sclerosis. The aim of this study was to identify specific characteristics of GM and WM structural networks in subjects with clinically isolated syndrome (CIS) in comparison to patients with early relapsing-remitting multiple sclerosis (RRMS). Twenty patients with CIS, 33 with RRMS, and 40 healthy subjects were investigated using 3 T-MRI. Diffusion tensor imaging was applied, together with probabilistic tractography and fractional anisotropy (FA) maps for WM and cortical thickness correlation analysis for GM, to determine the structural connectivity patterns...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/26769488/association-of-optic-radiation-integrity-with-cortical-thickness-in-children-with-anisometropic-amblyopia
#19
Shun Qi, Yun-Feng Mu, Long-Biao Cui, Rong Li, Mei Shi, Ying Liu, Jun-Qing Xu, Jian Zhang, Jian Yang, Hong Yin
Previous studies have indicated regional abnormalities of both gray and white matter in amblyopia. However, alterations of cortical thickness associated with changes in white matter integrity have rarely been reported. In this study, structural magnetic resonance imaging and diffusion tensor imaging (DTI) data were obtained from 15 children with anisometropic amblyopia and 15 age- and gender-matched children with normal sight. Combining DTI and surface-based morphometry, we examined a potential linkage between disrupted white matter integrity and altered cortical thickness...
February 2016: Neuroscience Bulletin
https://www.readbyqxmd.com/read/26752120/gray-matter-integrity-within-regions-of-the-dorsolateral-prefrontal-cortical-subcortical-network-predicts-executive-function-and-fine-motor-dexterity-in-spina-bifida
#20
Ashley L Ware, Paulina A Kulesz, Victoria J Williams, Jenifer Juranek, Paul T Cirino, Jack M Fletcher
OBJECTIVES: This study examined microstructural properties of cortical and subcortical gray matter components of the dorsolateral prefrontal (DLPFC) cortical-subcortical circuit in relation to parent-rated executive function and fine motor dexterity performance in youth with spina bifida myelomeningocele (SBM). Aberrant gray matter integrity of the DLPFC, basal ganglia nuclei, and thalamus were hypothesized to differentially relate to neurobehavioral outcomes. METHODS: Forty-nine youth between 8 and 18 years (M = 12...
May 2016: Neuropsychology
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