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(network or connectivity) AND (structural gray matter network OR cortical thickness)

Elijah Mak, Sean J Colloby, Alan Thomas, John T O'Brien
Late-life depression (LLD) has been associated with both generalized and focal neuroanatomical changes including gray matter atrophy and white matter abnormalities. However, previous literature has not been consistent and, in particular, its impact on the topology organization of brain networks remains to be established. In this multimodal study, we first examined cortical thickness, and applied graph theory to investigate structural covariance networks in LLD. Thirty-three subjects with LLD and 25 controls underwent T1-weighted, fluid-attenuated inversion recovery and clinical assessments...
August 24, 2016: Neurobiology of Aging
Paolo Frezzotti, Antonio Giorgio, Francesca Toto, Alessandro De Leucio, Nicola De Stefano
Our aim was to assess in primary open angle glaucoma (POAG), a major cause of irreversible blindness worldwide, whether diffuse brain changes recently shown in advanced stage can be detected since the early stage. We used multimodal magnetic resonance imaging (MRI) in 57 patients with the three POAG stages and in 29 age-matched normal controls (NC). Voxelwise statistics was performed with nonparametric permutation testing. Compared with NC, disrupted anatomical connectivity (AC) was found in the whole POAG group along the visual pathway and in nonvisual white matter tracts (P < 0...
August 9, 2016: Human Brain Mapping
Jin-Ju Yang, Hunki Kwon, Jong-Min Lee
Morphometric correlation networks of cortical thickness, surface area, and gray matter volume have statistically different structural topology. However, there is no report directly describing their correlation patterns in view of interregional covariance. Here, we examined the characteristics of the correlation patterns in three morphometric networks of cortical thickness, surface area, and gray matter volume using a Venn diagram concept across 314 normal subjects. We found that over 60% of all nonoverlapping correlation patterns emerged with divergent unique patterns, while there were 10% of all common edges in ipsilateral and homotopic regions among the three morphometric correlation networks...
2016: Scientific Reports
Kristen R Weaver, LeeAnne B Sherwin, Brian Walitt, Gail D'Eramo Melkus, Wendy A Henderson
AIM: To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome (IBS). METHODS: A database search for relevant literature was conducted using PubMed, Scopus and Embase in February 2015. Date filters were applied from the year 2009 and onward, and studies were limited to those written in the English language and those performed upon human subjects. The initial search yielded 797 articles, out of which 38 were pulled for full text review and 27 were included for study analysis...
May 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
Yu Mao, Na Sang, Yongchao Wang, Xin Hou, Hui Huang, Dongtao Wei, Jinfu Zhang, Jiang Qiu
Pathological narcissism is often characterized by arrogant behavior, a lack of empathy, and willingness to exploit other individuals. Generally, individuals with high levels of narcissism are more likely to suffer mental disorders. However, the brain structural basis of individual pathological narcissism trait among healthy people has not yet been investigated with surface-based morphometry. Thus, in this study, we investigated the relationship between cortical thickness (CT), cortical volume (CV), and individual pathological narcissism in a large healthy sample of 176 college students...
July 22, 2016: Neuroscience
Patrizia Dall'Acqua, Sönke Johannes, Ladislav Mica, Hans-Peter Simmen, Richard Glaab, Javier Fandino, Markus Schwendinger, Christoph Meier, Erika J Ulbrich, Andreas Müller, Lutz Jäncke, Jürgen Hänggi
Reduced integrity of white matter (WM) pathways and subtle anomalies in gray matter (GM) morphology have been hypothesized as mechanisms in mild traumatic brain injury (mTBI). However, findings on structural brain changes in early stages after mTBI are inconsistent and findings related to early symptoms severity are rare. Fifty-one patients were assessed with multimodal neuroimaging and clinical methods exclusively within 7 days following mTBI and compared to 53 controls. Whole-brain connectivity based on diffusion tensor imaging was subjected to network-based statistics, whereas cortical surface area, thickness, and volume based on T1-weighted MRI scans were investigated using surface-based morphometric analysis...
2016: Frontiers in Human Neuroscience
Budhachandra S Khundrakpam, John D Lewis, Lu Zhao, François Chouinard-Decorte, Alan C Evans
The developing human brain undergoes an astonishing sequence of events that continuously shape the structural and functional brain connectivity. Distinct regional variations in the timelines of maturational events (synaptogenesis and synaptic pruning) occurring at the synaptic level are reflected in brain measures at macroscopic resolution (cortical thickness and gray matter density). Interestingly, the observed brain changes coincide with cognitive milestones suggesting that the changing scaffold of brain circuits may subserve cognitive development...
July 1, 2016: NeuroImage
Muthuraman Muthuraman, Vinzenz Fleischer, Pierre Kolber, Felix Luessi, Frauke Zipp, Sergiu Groppa
Focal demyelinated lesions, diffuse white matter (WM) damage, and gray matter (GM) atrophy influence directly the disease progression in patients with multiple sclerosis. The aim of this study was to identify specific characteristics of GM and WM structural networks in subjects with clinically isolated syndrome (CIS) in comparison to patients with early relapsing-remitting multiple sclerosis (RRMS). Twenty patients with CIS, 33 with RRMS, and 40 healthy subjects were investigated using 3 T-MRI. Diffusion tensor imaging was applied, together with probabilistic tractography and fractional anisotropy (FA) maps for WM and cortical thickness correlation analysis for GM, to determine the structural connectivity patterns...
2016: Frontiers in Neuroscience
Shun Qi, Yun-Feng Mu, Long-Biao Cui, Rong Li, Mei Shi, Ying Liu, Jun-Qing Xu, Jian Zhang, Jian Yang, Hong Yin
Previous studies have indicated regional abnormalities of both gray and white matter in amblyopia. However, alterations of cortical thickness associated with changes in white matter integrity have rarely been reported. In this study, structural magnetic resonance imaging and diffusion tensor imaging (DTI) data were obtained from 15 children with anisometropic amblyopia and 15 age- and gender-matched children with normal sight. Combining DTI and surface-based morphometry, we examined a potential linkage between disrupted white matter integrity and altered cortical thickness...
February 2016: Neuroscience Bulletin
Ashley L Ware, Paulina A Kulesz, Victoria J Williams, Jenifer Juranek, Paul T Cirino, Jack M Fletcher
OBJECTIVES: This study examined microstructural properties of cortical and subcortical gray matter components of the dorsolateral prefrontal (DLPFC) cortical-subcortical circuit in relation to parent-rated executive function and fine motor dexterity performance in youth with spina bifida myelomeningocele (SBM). Aberrant gray matter integrity of the DLPFC, basal ganglia nuclei, and thalamus were hypothesized to differentially relate to neurobehavioral outcomes. METHODS: Forty-nine youth between 8 and 18 years (M = 12...
May 2016: Neuropsychology
J Christopher Edgar, Charles L Fisk, Song Liu, Juhi Pandey, John D Herrington, Robert T Schultz, Timothy P L Roberts
BACKGROUND: x03B3; (∼30-80 Hz) brain rhythms are thought to be abnormal in neurodevelopmental disorders such as schizophrenia and autism spectrum disorder (ASD). In adult populations, auditory 40-Hz click trains or 40-Hz amplitude-modulated tones are used to assess the integrity of superior temporal gyrus (STG) 40-Hz x03B3;-band circuits. As STG 40-Hz auditory steady-state responses (ASSRs) are not fully developed in children, tasks using these stimuli may not be optimal in younger patient populations...
2016: Developmental Neuroscience
N-Y Shin, Y S Shin, P H Lee, U Yoon, S Han, D J Kim, S-K Lee
BACKGROUND AND PURPOSE: The higher cortical burden of Lewy body and Alzheimer disease-type pathology has been reported to be associated with a faster onset of cognitive impairment of Parkinson disease. So far, there has been a few studies only about the changes of gray matter volume depending on duration of cognitive impairment in Parkinson disease. Therefore, our aim was to evaluate the different patterns of structural and functional changes in Parkinson disease with mild cognitive impairment according to the duration of parkinsonism before mild cognitive impairment...
May 2016: AJNR. American Journal of Neuroradiology
Mark Krongold, Cassandra Cooper, Signe Bray
Brain maturation across childhood and adolescence is characterized by cortical thickness (CT) and volume contraction, and early expansion of surface area (SA). These processes occur asynchronously across the cortical surface, with functional, topographic, and network-based organizing principles proposed to account for developmental patterns. Characterizing regions undergoing synchronized development can help determine whether "maturational networks" overlap with well-described functional networks, and whether they are targeted by neurodevelopmental and psychiatric disorders...
December 9, 2015: Cerebral Cortex
A Manzouri, K Kosidou, I Savic
: Gender dysphoria (GD) is characterized by incongruence between onés gender assigned at birth and the gender that one identifies with. The biological mechanisms of GD are unclear, especially in female-to-male transsexuals (FtM-TR). Here, we investigate whether distinct structural and functional patterns along cerebral midline networks processing own-body perception may constitute a biological correlate. METHOD: MRI of functional connectivity, cortical thickness, surface area, and gray matter volume was carried out in 28 female-to-male transsexuals (FtM-TR) and 68 cis-sexual controls (34 male)...
December 4, 2015: Cerebral Cortex
Guangyao Jiang, Xuntao Yin, Chuanming Li, Lei Li, Lu Zhao, Alan C Evans, Tianzi Jiang, Jixiang Wu, Jian Wang
Accumulating evidence has indicated that amputation induces functional reorganization in the sensory and motor cortices. However, the extent of structural changes after lower limb amputation in patients without phantom pain remains uncertain. We studied 17 adult patients with right lower limb amputation and 18 healthy control subjects using T1-weighted magnetic resonance imaging and diffusion tensor imaging. Cortical thickness and fractional anisotropy (FA) of white matter (WM) were investigated. In amputees, a thinning trend was seen in the left premotor cortex (PMC)...
2015: Neural Plasticity
Christine Lycke Brandt, Nhat Trung Doan, Siren Tønnesen, Ingrid Agartz, Kenneth Hugdahl, Ingrid Melle, Ole A Andreassen, Lars T Westlye
Schizophrenia (SZ) is a psychotic disorder with significant cognitive dysfunction. Abnormal brain activation during cognitive processing has been reported, both in task-positive and task-negative networks. Further, structural cortical and subcortical brain abnormalities have been documented, but little is known about how task-related brain activation is associated with brain anatomy in SZ compared to healthy controls (HC). Utilizing linked independent component analysis (LICA), a data-driven multimodal analysis approach, we investigated structure-function associations in a large sample of SZ (n = 96) and HC (n = 142)...
2015: NeuroImage: Clinical
Susanne G Mueller, Peter Ng, Thomas Neylan, Scott Mackin, Owen Wolkowitz, Synthia Mellon, Xiaodan Yan, Janine Flory, Rachel Yehuda, Charles R Marmar, Michael W Weiner
Posttraumatic stress disorder (PTSD) is characterized by atrophy within the prefrontal-limbic network. Graph analysis was used to investigate to what degree atrophy in PTSD is associated with impaired structural connectivity within prefrontal limbic network (restricted) and how this affects the integration of the prefrontal limbic network with the rest of the brain (whole-brain). 85 male veterans (45 PTSD neg, 40 PTSD pos) underwent volumetric MRI on a 3T MR. Subfield volumes were obtained using a manual labeling scheme and cortical thickness measurements and subcortical volumes from FreeSurfer...
November 30, 2015: Psychiatry Research
Julia Richter, Romy Henze, Kilian Vomstein, Bram Stieltjes, Peter Parzer, Johann Haffner, Daniel Brandeis, Luise Poustka
Symptomatology and behavioral characteristics in autism spectrum disorders (ASD) have increasingly been linked to abnormalities in early brain growth patterns of affected children. Studies investigating specific components of gray matter structure, such as cortical thickness (CT), have produced conflicting results, and have rarely included additional measures of social impairment. In the present study, we applied a surface-based whole brain analysis to investigate CT in a sample of 36 pre-adolescent children [18 subjects with ASD (IQ mean: 111) and 18 healthy controls (IQ mean: 112...
October 30, 2015: Psychiatry Research
Anders Hougaard
Migraine sufferers with aura often report visual discomfort outside of attacks and many consider bright or flickering light an attack-precipitating factor. The nature of this visual hypersensitivity and its relation to the underlying pathophysiology of the migraine aura is unknown. A useful technology to study these features of migraine with aura (MA) is functional magnetic resonance imaging (fMRI), which has the potential not only to detect, but also to localize hypersensitive cortex. The main objective of this thesis was to investigate the cortical responsivity of patients with MA during visual stimulation using fMRI...
August 2015: Danish Medical Journal
Seong Hoon Kim, Sung-Chul Lim, Woojun Kim, Oh-Hun Kwon, Seun Jeon, Jong-Min Lee, Young-Min Shon
PURPOSE: An increasing amount of evidence has demonstrated that juvenile myoclonic epilepsy (JME) is associated with structural abnormalities in not only the thalamofrontal system but its adjacent regions such as temporal or parieto-occipital areas. The goal of this study was to systematically characterize morphological changes and the subsequent pathophysiological implications in JME patients using the combined structural and diffusion tensor MRI analysis. METHODS: Comparisons of white matter (WM) water diffusivity and gray matter (GM) cortical thickness were analyzed with tract-based spatial statistics (TBSS) and a Constrained Laplacian-based Anatomic Segmentation with Proximity (CLASP) algorithm, respectively...
August 2015: Seizure: the Journal of the British Epilepsy Association
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