keyword
MENU ▼
Read by QxMD icon Read
search

zidar

keyword
https://www.readbyqxmd.com/read/29324314/down-regulation-of-mir-133a-b-in-patients-with-myocardial-infarction-correlates-with-the-presence-of-ventricular-fibrillation
#1
Emanuela Boštjančič, Tanisa Brandner, Nina Zidar, Damjan Glavač, Dušan Štajer
MicroRNAs (miRNAs) are important regulators of physiologic and pathologic conditions of the heart. Animal models of heart diseases have shown that miRNAs may contribute to the development of arrhythmias. However, little is known about the expression of muscle- and cardiac-specific miRNAs in patients with myocardial infarction (MI) who have developed ventricular fibrillation (VF). Our study included 47 patients who had died from myocardial infarction (MI), 23 with clinically proven VF and 24 without VF. Autopsy samples of infarcted tissue and remote myocardium were available (n = 94)...
January 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29304380/the-fate-of-benzotriazole-pollutants-in-an-urban-oxic-intergranular-aquifer
#2
Branka Trček, Dušan Žigon, Vlasta Kramarič Zidar, Primož Auersperger
Benzotriazoles (BTs) are considered as Contaminants of Emerging Concern (CECs); however, information about their fate in aquifers continues to be absent. This was the focus of the present study, which provides the first evidence for relevant BTs' degradation products (BTTPs) in urban aquifers that may impact the groundwater quality. The mechanisms and biotransformation pathways of BTs were investigated in an oxic intergranular medium. The BTs and BTTPs were identified and quantified by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) analytical techniques based on reference standards and internal materials...
December 26, 2017: Water Research
https://www.readbyqxmd.com/read/29239018/design-synthesis-and-biological-evaluation-of-1-ethyl-3-thiazol-2-yl-urea-derivatives-as-escherichia-coli-dna-gyrase-inhibitors
#3
Tihomir Tomašič, Michaela Barančoková, Nace Zidar, Janez Ilaš, Päivi Tammela, Danijel Kikelj
Discovery of novel DNA gyrase B inhibitors remains an attractive field in the search for new antibacterial drugs to overcome the known bacterial resistance mechanisms. In the present study, we designed and synthesized novel ethylurea derivatives of 4,5,6,7-tetrahydrobenzo[1,2-d]thiazole-2,6-diamine, 2-(2-aminothiazol-4-yl)acetic acid, and benzo[1,2-d]thiazole-2,6-diamine and evaluated their Escherichia coli DNA gyrase inhibition. The most potent DNA gyrase inhibitors in the prepared library of compounds were benzo[1,2-d]thiazoles 32-34, 36, and 37 with IC50 values in the low micromolar range...
December 14, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29216997/the-state-of-the-absorb-bioresorbable%C3%A2-scaffold-consensus-from-an-expert-panel
#4
REVIEW
Sripal Bangalore, Hiram G Bezerra, David G Rizik, Ehrin J Armstrong, Bruce Samuels, Srihari S Naidu, Cindy L Grines, Malcolm T Foster, James W Choi, Barry D Bertolet, Atman P Shah, Rebecca Torguson, Surendra B Avula, John C Wang, James P Zidar, Aziz Maksoud, Arun Kalyanasundaram, Steven J Yakubov, Bassem M Chehab, Anthony J Spaedy, Srini P Potluri, Ronald P Caputo, Ashok Kondur, Robert F Merritt, Amir Kaki, Ramon Quesada, Manish A Parikh, Catalin Toma, Fadi Matar, Joseph DeGregorio, William Nicholson, Wayne Batchelor, Raghava Gollapudi, Ethan Korngold, Riyaz Sumar, George S Chrysant, Jun Li, John B Gordon, Rajesh M Dave, Guilherme F Attizzani, Tom P Stys, Osvaldo S Gigliotti, Bruce E Murphy, Stephen G Ellis, Ron Waksman
Significant progress has been made in the percutaneous coronary intervention technique from the days of balloon angioplasty to modern-day metallic drug-eluting stents (DES). Although metallic stents solve a temporary problem of acute recoil following balloon angioplasty, they leave behind a permanent problem implicated in very late events (in addition to neoatherosclerosis). BRS were developed as a potential solution to this permanent problem, but the promise of these devices has been tempered by clinical trials showing increased risk of safety outcomes, both early and late...
December 11, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29206345/synthesis-and-evaluation-of-n-phenylpyrrolamides-as-dna-gyrase-b-inhibitors
#5
Martina Durcik, Päivi Tammela, Michaela Barančoková, Tihomir Tomašič, Janez Ilaš, Danijel Kikelj, Nace Zidar
ATP-competitive inhibitors of DNA gyrase and topoisomerase IV (topo IV) are among the most interesting classes of antibacterial drugs that do not have any representative in the antibacterial pipeline. We have developed thirty-two new N-phenylpyrrolamides and evaluated them against DNA gyrase and topoisomerase IV from Escherichia coli and Staphylococcus aureus. Antibacterial activities were studied against Gram-positive and Gram-negative bacterial strains. The most potent compound displayed an IC50 of 47 nM against E...
December 5, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29189208/extraneuraxial-hemangioblastoma-clinicopathologic-features-and-review-of-the-literature
#6
Michele Bisceglia, Lucia A Muscarella, Carlos A Galliani, Nina Zidar, David Ben-Dor, Gianandrea Pasquinelli, Annamaria la Torre, Angelo Sparaneo, Julie C Fanburg-Smith, Janez Lamovec, Michal Michal, Carlos E Bacchi
Extraneuraxial hemangioblastoma occurs in nervous paraneuraxial structures, somatic tissues, and visceral organs, as part of von Hippel-Lindau disease (VHLD) or in sporadic cases. The VHL gene plausibly plays a key role in the initiation and tumorigenesis of both central nervous system and extraneuraxial hemangioblastoma, therefore, the underlying molecular and genetic mechanisms of the tumor growth are initially reviewed. The clinical criteria for the diagnosis of VHLD are summarized, with emphasis on the distinction of sporadic hemangioblastoma from the form fruste of VHLD (eg, hemangioblastoma-only VHLD)...
November 20, 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/29112065/the-effects-of-hiv-and-smoking-on-aortic-and-splenic-inflammation
#7
Chris T Longenecker, Claire E Sullivan, Justin Morrison, Corrilynn O Hileman, David A Zidar, Robert Gilkeson, James O'Donnell, Grace A McComsey
OBJECTIVE: To determine the association of smoking and HIV status with tissue specific inflammation measured by flurodeoxyglucose positron emission tomography (FDG-PET). DESIGN: Cross-sectional. METHODS: We prospectively enrolled 55 HIV+ subjects on stable antiretroviral therapy and 19 age-matched HIV-uninfected controls without known CVD. We measured aortic target-to-background ratio (TBR) and spleen standardized uptake values (SUV) three hours post-FDG, and used regression models to examine the independent association of HIV and smoking status with PET variables...
November 2, 2017: AIDS
https://www.readbyqxmd.com/read/29098203/prospective-analysis-of-lipid-composition-changes-with-antiretroviral-therapy-and-immune-activation-in-persons-living-with-hiv
#8
Martha A Belury, Emily Bowman, Janelle Gabriel, Brandon Snyder, Manjusha Kulkarni, Marilly Palettas, Xiaokui Mo, Jordan E Lake, David Zidar, Scott F Sieg, Benigno Rodriguez, Martin P Playford, Adriana Andrade, Daniel R Kuritzkes, Nehal N Mehta, Michael M Lederman, Nicholas T Funderburg
Background: Lipid profiles are altered by HIV infection and antiretroviral therapy (ART). Among HIV-uninfected (HIV-) populations the concentrations of various lipid classes (ie, lyso-phosphatidylcholine, LPC) and their saturated (SaFA), mono-unsaturated (MUFA), and polyunsaturated fatty acid (PUFA) composition are related to cardiometabolic disease risk. Associations between changes in the lipidome and immune activation in HIV-infected (HIV+) individuals beginning ART have not been described...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28847012/accuracy-of-cardiovascular-risk-prediction-varies-by-neighborhood-socioeconomic-position-a-retrospective-cohort-study
#9
Jarrod E Dalton, Adam T Perzynski, David A Zidar, Michael B Rothberg, Claudia J Coulton, Alex T Milinovich, Douglas Einstadter, James K Karichu, Neal V Dawson
Background: Inequality in health outcomes in relation to Americans' socioeconomic position is rising. Objective: First, to evaluate the spatial relationship between neighborhood disadvantage and major atherosclerotic cardiovascular disease (ASCVD)-related events; second, to evaluate the relative extent to which neighborhood disadvantage and physiologic risk account for neighborhood-level variation in ASCVD event rates. Design: Observational cohort analysis of geocoded longitudinal electronic health records...
October 3, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28845283/a32%C3%A2-search-for-viral-integration-insertion-sites-into-the-human-genome-strategy-matters
#10
T M Zorec, L Hošnjak, B Kocjan, N Gale, N Zidar, P Strojan, M Poljak
No abstract text is available yet for this article.
March 2017: Virus Evolution
https://www.readbyqxmd.com/read/28808819/separating-the-idea-from-the-action-a-sloreta-study
#11
Martin Rakusa, Pierpaolo Busan, Piero Paolo Battaglini, Janez Zidar
Simple imaginary movements activate similar cortical and subcortical areas to actual movements, chiefly in the sensory-motor network. However, only a few studies also examined the imagery of more skilful movements such as reaching. Ten volunteers performed reaching movements or imagined the same movements. EEG was simultaneously recorded and analysed with sLORETA, which compared the preparation for actual and imagined reaching with respect to their baseline and between tasks. Major differences between them were found at three time intervals after target presentation, always in favour of the actual reaching condition...
August 14, 2017: Brain Topography
https://www.readbyqxmd.com/read/28802123/clathrodin-hymenidin-and-oroidin-and-their-synthetic-analogues-as-inhibitors-of-the-voltage-gated-potassium-channels
#12
Nace Zidar, Aleš Žula, Tihomir Tomašič, Marc Rogers, Robert W Kirby, Jan Tytgat, Steve Peigneur, Danijel Kikelj, Janez Ilaš, Lucija Peterlin Mašič
We have prepared three alkaloids from the Agelas sponges, clathrodin, hymenidin and oroidin, and a series of their synthetic analogues, and evaluated their inhibitory effect against six isoforms of the Kv1 subfamily of voltage-gated potassium channels, Kv1.1-Kv1.6, expressed in Chinese Hamster ovary (CHO) cells using automated patch clamp electrophysiology assay. The most potent inhibitor was the (E)-N-(3-(2-amino-1H-imidazol-4-yl)allyl)-4,5-dichloro-1H-pyrrole-2-carboxamide (6g) with IC50 values between 1...
October 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28713869/association-of-anisocytosis-with-markers-of-immune-activation-and-exhaustion-in-treated-hiv
#13
Sadeer G Al-Kindi, David A Zidar, Grace A McComsey, Chris T Longenecker
BACKGROUND: Treated HIV infection is associated with heightened inflammation which can contribute to increased risk of cardiovascular disease (CVD). We have previously shown that anisocytosis, as measured by red cell distribution width (RDW), is independently associated with prevalent CVD in people living with HIV (PLHIV). In this study, we sought to identify immune correlates of RDW in PLHIV receiving antiretroviral therapy. METHODS: We performed a cross-sectional and longitudinal analysis of 147 virally-suppressed PLHIV, who had LDL < 130 mg/dL and evidence of heightened inflammation, in a randomized trial of statin therapy...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28699108/the-role-of-epithelial-mesenchymal-transition-in-squamous-cell-carcinoma-of-the-oral-cavity
#14
Nina Zidar, Emanuela Boštjančič, Marija Malgaj, Nina Gale, Tadej Dovšak, Vojko Didanovič
Epithelial-mesenchymal transition (EMT) has emerged as a possible mechanism of cancer metastasizing, but strong evidence for EMT involvement in human cancer is lacking. Our aim was to compare oral spindle cell carcinoma (SpCC) as an example of EMT with oral conventional squamous cell carcinoma (SCC) with and without nodal metastases to test the hypothesis that EMT contributes to metastasizing in oral SCC. Thirty cases of oral SCC with and without nodal metastasis and 15 cases of SpCC were included. Epithelial (cytokeratin, E-cadherin), mesenchymal (vimentin, N-cadherin), and stem cell markers (ALDH-1, CD44, Nanog, Sox-2) and transcription repressors (Snail, Slug, Twist) were analyzed immunohistochemically...
July 12, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28593474/high-throughput-prediction-approach-for-monoclonal-antibody-aggregation-at-high-concentration
#15
Mitja Zidar, Ana Šušterič, Miha Ravnik, Drago Kuzman
PURPOSE: Characterization of the monoclonal antibody aggregation process and identification of stability factors that could be used as indicators of aggregation propensity with an emphasis on a large number of samples and low protein material consumption. METHODS: Differential scanning calorimetry, dynamic light scattering and size exclusion chromatography were used as the main methodological approaches. Conformational stability, colloidal stability and aggregation kinetics were assessed for two different IgG monoclonal antibody (mAbs) subclasses...
September 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28582027/restenosis-of-the-coronary-arteries-past-present-future-directions
#16
REVIEW
Julius B Elmore, Emile Mehanna, Sahil A Parikh, David A Zidar
Restenosis is a pathologic response to vascular injury, characterized by neointimal hyperplasia and progressive narrowing of a stented vessel segment. Although advances in stent design have led to a dramatic reduction in the incidence of restenosis, it continues to represent the most common cause of target lesion failure following percutaneous coronary intervention. Efforts to maximize restenosis prevention, through careful consideration of modifiable risk factors and an individualized approach, are critical, as restenosis, once established, can be particularly difficult to treat...
July 2016: Interventional Cardiology Clinics
https://www.readbyqxmd.com/read/28486514/comparative-study-of-acetylcholinesterase-and-glutathione-s-transferase-activities-of-closely-related-cave-and-surface-asellus-aquaticus-isopoda-crustacea
#17
COMPARATIVE STUDY
Anita Jemec, David Škufca, Simona Prevorčnik, Žiga Fišer, Primož Zidar
The freshwater isopod crustacean Asellus aquaticus has recently been developed as an emerging invertebrate cave model for studying evolutionary and developmental biology. Mostly morphological and genetic differences between cave and surface A. aquaticus populations have been described up to now, while scarce data are available on other aspects, including physiology. The purpose of this study was to advance our understanding of the physiological differences between cave A. aquaticus and its surface-dwelling counterparts...
2017: PloS One
https://www.readbyqxmd.com/read/28471091/superb-final-3-year-outcomes-using-interwoven-nitinol-biomimetic-supera-stent
#18
Lawrence A Garcia, Kenneth R Rosenfield, Christopher D Metzger, Frank Zidar, Ashish Pershad, Jeffrey J Popma, Margo Zaugg, Michael R Jaff
IMPORTANCE: Long-term outcomes of an interwoven nitinol stent design represent the best in class for treatment of lower limb arterial obstructive disease METHODS: The subjects were enrolled in an open single arm study comparing the outcomes to an FDA mandated objective performance goal (OPG). RESULTS: About 325 patients (264 intention-to-treat and 64 roll-in subjects) were enrolled. Mean follow-up period was 887+/- 352 days. Treated lesion lengths were 7.8 cm ± 4...
June 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28394105/introducing-scientific-writing-as-mandatory-topic-in-bachelor-nursing-program-experience-of-the-university-of-dubrovnik-croatia
#19
Mihaela Zidarić, Višnja Vičić-Hudorović, Narcis Hudorović
One of the methods that have been used to encourage student reflection skills is scientific writing. The purpose of this article is to discuss implementation of obligatory study topic with the main objective to increase the skills of scientific writing among students of Bachelor Nursing Curriculum and its relation to scientific publishing volume of Bachelor degree students from the University of Dubrovnik. By searching the local rank database called HRČAK, data were collected on publication volume of the Bachelor course students at the University of Dubrovnik from 2010 to 2014...
June 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/28270667/response-to-zidar-and-tepes
#20
S Pillet, B Pozzetto, X Roblin
No abstract text is available yet for this article.
March 2017: American Journal of Gastroenterology
keyword
keyword
92124
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"