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https://www.readbyqxmd.com/read/27889490/inhibition-of-cathepsin-x-reduces-the-strength-of-microglial-mediated-neuroinflammation
#1
Anja Pišlar, Biljana Božić, Nace Zidar, Janko Kos
Inflammation plays a central role in the processes associated with neurodegeneration. The inflammatory response is mediated by activated microglia that release inflammatory mediators to the neuronal environment. Microglia-derived lysosomal cathepsins, including cathepsin X, are increasingly recognized as important mediators of the inflammation involved in lipopolysaccharide (LPS)-induced neuroinflammation. The current study was undertaken to investigate the role of cathepsin X and its molecular target, γ-enolase, in neuroinflammation and to elucidate the underlying mechanism...
November 23, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27880843/highly-divergent-clostridium-difficile-strains-isolated-from-the-environment
#2
Sandra Janezic, Mojca Potocnik, Valerija Zidaric, Maja Rupnik
Clostridium difficile is one of the most important human and animal pathogens. However, the bacterium is ubiquitous and can be isolated from various sources. Here we report the prevalence and characterization of C. difficile in less studied environmental samples, puddle water (n = 104) and soil (n = 79). C. difficile was detected in 14.4% of puddle water and in 36.7% of soil samples. Environmental strains displayed antimicrobial resistance patterns comparable to already published data of human and animal isolates...
2016: PloS One
https://www.readbyqxmd.com/read/27862875/cost-awareness-decreases-total-percutaneous-coronary-intervention-procedural-cost-the-shopping-show-how-options-in-price-for-procedures-can-be-influenced-greatly-trial
#3
Elad Asher, John Mansour, Adam Wheeler, Daniel Kendrick, Michael Cunningham, Sahil Parikh, David Zidar, Todd Harford, Daniel I Simon, Vikram S Kashyap
OBJECTIVES: We initiated the SHOPPING Trial (Show How Options in Price for Procedures can be InflueNced Greatly) to see if percutaneous coronary intervention (PCI) procedures can be performed at a lower cost in a single institution. BACKGROUND: Procedural practice variability is associated with inefficiency and increased cost. We hypothesized that announcing costs for all supplies during a catheterization procedure and reporting individual operator cost relative to peers would spur cost reduction without affecting clinical outcomes...
November 10, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27828877/elevated-red-cell-distribution-width-rdw-identifies-elevated-cardiovascular-disease-risk-in-patients-with-hiv-infection
#4
Sadeer G Al-Kindi, Chang H Kim, Stephen R Morris, Michael L Freeman, Nicholas T Funderburg, Benigno Rodriguez, Grace A McComsey, Jarrod E Dalton, Daniel I Simon, Michael M Lederman, Chris T Longenecker, David A Zidar
Red cell distribution width (RDW) is linked to cardiovascular risk in the general population, an association that might be driven by inflammation. Whether this relationship holds for patients with Human Immunodeficiency Virus (HIV) infection has not been previously studied. Using a large clinical registry, we show that elevated RDW (>14.5%) is independently associated with increased risk of coronary artery disease (odds ratio (OR) 1.39 [1.25-1.55]), peripheral vascular disease (OR 1.41 [1.29-1.53]), myocardial infarction (1...
November 4, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27808131/cytomegalovirus-reactivation-in-ulcerative-colitis-what-can-we-learn-from-pathology
#5
Nina Zidar, Katja Tepeš
No abstract text is available yet for this article.
November 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27751518/esophageal-squamous-cell-papilloma
#6
Matjaž Homan, Mario Poljak, Nina Zidar
No abstract text is available yet for this article.
October 14, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27703039/inflammatory-function-of-cx3cr1-cd8-t-cells-in-treated-hiv-infection-is-modulated-by-platelet-interactions
#7
Joseph C Mudd, Soumya Panigrahi, Benjamin Kyi, So Hee Moon, Maura M Manion, Souheil-Antoine Younes, Scott F Sieg, Nicholas T Funderburg, David A Zidar, Michael M Lederman, Michael L Freeman
Increases in inflammation, coagulation, and CD8 T cell numbers are associated with elevated cardiovascular disease (CVD) risk in antiretroviral therapy (ART)-treated HIV infection. Circulating memory CD8 T cells that express the vascular endothelium-homing receptor CX3CR1 (fractalkine receptor) are enriched in ART-treated HIV-infected subjects. Thrombin-activated receptor (PAR-1) expression is increased in ART-treated HIV-infected subjects and is particularly elevated on CX3CR1+ CD8 T cells, suggesting that these cells could interact with coagulation elements...
October 4, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27631161/beyond-aphasia-altered-eeg-connectivity-in-broca-s-patients-during-working-memory-task
#8
Veronika Rutar Gorišek, Vlasta Zupanc Isoski, Aleš Belič, Christina Manouilidou, Blaž Koritnik, Jure Bon, Nuška Pečarič Meglič, Matej Vrabec, Janez Žibert, Grega Repovš, Janez Zidar
Broca's region and adjacent cortex presumably take part in working memory (WM) processes. Electrophysiologically, these processes are reflected in synchronized oscillations. We present the first study exploring the effects of a stroke causing Broca's aphasia on these processes and specifically on synchronized functional WM networks. We used high-density EEG and coherence analysis to map WM networks in ten Broca's patients and ten healthy controls during verbal WM task. Our results demonstrate that a stroke resulting in Broca's aphasia also alters two distinct WM networks...
September 12, 2016: Brain and Language
https://www.readbyqxmd.com/read/27455348/genome-wide-association-analyses-identify-new-risk-variants-and-the-genetic-architecture-of-amyotrophic-lateral-sclerosis
#9
Wouter van Rheenen, Aleksey Shatunov, Annelot M Dekker, Russell L McLaughlin, Frank P Diekstra, Sara L Pulit, Rick A A van der Spek, Urmo Võsa, Simone de Jong, Matthew R Robinson, Jian Yang, Isabella Fogh, Perry Tc van Doormaal, Gijs H P Tazelaar, Max Koppers, Anna M Blokhuis, William Sproviero, Ashley R Jones, Kevin P Kenna, Kristel R van Eijk, Oliver Harschnitz, Raymond D Schellevis, William J Brands, Jelena Medic, Androniki Menelaou, Alice Vajda, Nicola Ticozzi, Kuang Lin, Boris Rogelj, Katarina Vrabec, Metka Ravnik-Glavač, Blaž Koritnik, Janez Zidar, Lea Leonardis, Leja Dolenc Grošelj, Stéphanie Millecamps, François Salachas, Vincent Meininger, Mamede de Carvalho, Susana Pinto, Jesus S Mora, Ricardo Rojas-García, Meraida Polak, Siddharthan Chandran, Shuna Colville, Robert Swingler, Karen E Morrison, Pamela J Shaw, John Hardy, Richard W Orrell, Alan Pittman, Katie Sidle, Pietro Fratta, Andrea Malaspina, Simon Topp, Susanne Petri, Susanne Abdulla, Carsten Drepper, Michael Sendtner, Thomas Meyer, Roel A Ophoff, Kim A Staats, Martina Wiedau-Pazos, Catherine Lomen-Hoerth, Vivianna M Van Deerlin, John Q Trojanowski, Lauren Elman, Leo McCluskey, A Nazli Basak, Ceren Tunca, Hamid Hamzeiy, Yesim Parman, Thomas Meitinger, Peter Lichtner, Milena Radivojkov-Blagojevic, Christian R Andres, Cindy Maurel, Gilbert Bensimon, Bernhard Landwehrmeyer, Alexis Brice, Christine A M Payan, Safaa Saker-Delye, Alexandra Dürr, Nicholas W Wood, Lukas Tittmann, Wolfgang Lieb, Andre Franke, Marcella Rietschel, Sven Cichon, Markus M Nöthen, Philippe Amouyel, Christophe Tzourio, Jean-François Dartigues, Andre G Uitterlinden, Fernando Rivadeneira, Karol Estrada, Albert Hofman, Charles Curtis, Hylke M Blauw, Anneke J van der Kooi, Marianne de Visser, An Goris, Markus Weber, Christopher E Shaw, Bradley N Smith, Orietta Pansarasa, Cristina Cereda, Roberto Del Bo, Giacomo P Comi, Sandra D'Alfonso, Cinzia Bertolin, Gianni Sorarù, Letizia Mazzini, Viviana Pensato, Cinzia Gellera, Cinzia Tiloca, Antonia Ratti, Andrea Calvo, Cristina Moglia, Maura Brunetti, Simona Arcuti, Rosa Capozzo, Chiara Zecca, Christian Lunetta, Silvana Penco, Nilo Riva, Alessandro Padovani, Massimiliano Filosto, Bernard Muller, Robbert Jan Stuit, Ian Blair, Katharine Zhang, Emily P McCann, Jennifer A Fifita, Garth A Nicholson, Dominic B Rowe, Roger Pamphlett, Matthew C Kiernan, Julian Grosskreutz, Otto W Witte, Thomas Ringer, Tino Prell, Beatrice Stubendorff, Ingo Kurth, Christian A Hübner, P Nigel Leigh, Federico Casale, Adriano Chio, Ettore Beghi, Elisabetta Pupillo, Rosanna Tortelli, Giancarlo Logroscino, John Powell, Albert C Ludolph, Jochen H Weishaupt, Wim Robberecht, Philip Van Damme, Lude Franke, Tune H Pers, Robert H Brown, Jonathan D Glass, John E Landers, Orla Hardiman, Peter M Andersen, Philippe Corcia, Patrick Vourc'h, Vincenzo Silani, Naomi R Wray, Peter M Visscher, Paul I W de Bakker, Michael A van Es, R Jeroen Pasterkamp, Cathryn M Lewis, Gerome Breen, Ammar Al-Chalabi, Leonard H van den Berg, Jan H Veldink
To elucidate the genetic architecture of amyotrophic lateral sclerosis (ALS) and find associated loci, we assembled a custom imputation reference panel from whole-genome-sequenced patients with ALS and matched controls (n = 1,861). Through imputation and mixed-model association analysis in 12,577 cases and 23,475 controls, combined with 2,579 cases and 2,767 controls in an independent replication cohort, we fine-mapped a new risk locus on chromosome 21 and identified C21orf2 as a gene associated with ALS risk...
September 2016: Nature Genetics
https://www.readbyqxmd.com/read/27424053/impact-of-ionophore-monensin-on-performance-and-cu-uptake-in-earthworm-eisenia-andrei-exposed-to-copper-contaminated-soil
#10
Primož Zidar, Monika Kos, Katarina Vogel-Mikuš, Johannes Teun van Elteren, Marta Debeljak, Suzana Žižek
Exposure of beneficial soil organisms to chemical mixtures is of great concern and can result in unexpected deleterious consequences. We investigated the effects of concurrent soil contamination with monensin, a veterinary pharmaceutical and feed additive, and copper, on earthworm copper uptake and reproductive success. The animals were exposed for 14 or 28 days to both substances and the results showed that the Cu body burden of earthworms increases in the presence of monensin. The harmful effects of Cu on earthworm cocoon production were considerably higher when monensin was also present in the soil...
October 2016: Chemosphere
https://www.readbyqxmd.com/read/27329431/early-experience-affects-adult-personality-in-the-red-junglefowl-a-role-for-cognitive-stimulation
#11
Josefina Zidar, Enrico Sorato, Ann-Marie Malmqvist, Emelie Jansson, Charlotte Rosher, Per Jensen, Anna Favati, Hanne Løvlie
Despite intense research efforts, biologists are still puzzled by the existence of animal personality. While recent studies support a link between cognition and personality, the directionality of this relationship still needs to be clarified. Early-life experiences can affect adult behaviour, and among these, cognitive stimulation has been suggested theoretically to influence personality. Yet, the influence of early cognitive stimulation has rarely been explored in empirical investigations of animal behaviour and personality...
June 18, 2016: Behavioural Processes
https://www.readbyqxmd.com/read/27241216/evolution-of-brain-body-allometry-in-lake-tanganyika-cichlids
#12
Masahito Tsuboi, Alexander Kotrschal, Alexander Hayward, Severine Denise Buechel, Josefina Zidar, Hanne Løvlie, Niclas Kolm
Brain size is strongly associated with body size in all vertebrates. This relationship has been hypothesized to be an important constraint on adaptive brain size evolution. The essential assumption behind this idea is that static (i.e., within species) brain-body allometry has low ability to evolve. However, recent studies have reported mixed support for this view. Here, we examine brain-body static allometry in Lake Tanganyika cichlids using a phylogenetic comparative framework. We found considerable variation in the static allometric intercept, which explained the majority of variation in absolute and relative brain size...
July 2016: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/27131828/the-role-of-transcranial-magnetic-stimulation-in-evaluation-of-motor-cortex-excitability-in-rett-syndrome
#13
Natalija Krajnc, Janez Zidar
UNLABELLED: Rett syndrome (RTT) is a frequent neurodevelopmental disorder confirmed by clinical criteria and supported by the methyl-CpG-binding protein 2 gene (MECP2) mutation. A short central motor conduction time (CMCT) was reported in transcranial magnetic stimulation (TMS) studies performed in RTT. This was attributed to hyperexcitability of the motor cortex and/or spinal motor neurons, but was not studied further. AIM: We performed TMS in RTT to evaluate motor cortex excitability by determining the cortical motor threshold (CMT) and motor cortex inhibition by the cortical silent period (CSP) besides measuring CMCT...
December 0: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27113480/down-regulation-of-micrornas-of-the-mir-200-family-and-up-regulation-of-snail-and-slug-in-inflammatory-bowel-diseases-hallmark-of-epithelial-mesenchymal-transition
#14
Nina Zidar, Emanuela Boštjančič, Miha Jerala, Nika Kojc, David Drobne, Borut Štabuc, Damjan Glavač
Fibrosis is an important feature of inflammatory bowel diseases (IBD), particularly Crohn's disease (CD), but its pathogenesis is poorly understood. To determine the postulated involvement of epithelial-mesenchymal transition (EMT) in the development of fibrosis in IBD, we analysed the expression profiles of the miR-200 family which has been shown to induce EMT in experimental models and various human diseases. We also analysed the expression of Snail and Slug, postulated targets of the investigated microRNAs...
October 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27100032/new-n-phenyl-4-5-dibromopyrrolamides-and-n-phenylindolamides-as-atpase-inhibitors-of-dna-gyrase
#15
Nace Zidar, Tihomir Tomašič, Helena Macut, Anja Sirc, Matjaž Brvar, Sofia Montalvão, Päivi Tammela, Janez Ilaš, Danijel Kikelj
Following the withdrawal of novobiocin, the introduction of a new ATPase inhibitor of DNA gyrase to the clinic would add the first representative of this mechanistic class to the antibacterial pipeline. This would be of great importance because of the well-known problems associated with antibacterial resistance. Using structure-based design and starting from the recently determined crystal structure of the N-phenyl-4,5-dibromopyrrolamide inhibitor-DNA gyrase B complex, we have prepared 28 new N-phenyl-4,5-dibromopyrrolamides and N-phenylindolamides and evaluated them against DNA gyrase from Escherichia coli...
July 19, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27095618/sporulation-properties-and-antimicrobial-susceptibility-in-endemic-and-rare-clostridium-difficile-pcr-ribotypes
#16
Valerija Zidaric, Maja Rupnik
Increased sporulation and antibiotic resistance have been proposed to be associated with certain Clostridium difficile epidemic strains such as PCR ribotype 027. In this study we examined these properties in another widespread PCR ribotype, 014/020, in comparison to prevalent PCR ribotype 002 and a group of rarely represented PCR ribotypes. Highest sporulation was observed in 014/020 strains at 24 h, while after 72 h PCR ribotype 002 and rare PCR ribotypes formed higher total number of spores. PCR ribotype 014/020 strains exhibited slightly higher resistance to tested antimicrobials, followed by group of rare PCR ribotypes and less common PCR ribotype 002...
June 2016: Anaerobe
https://www.readbyqxmd.com/read/27077123/role-of-natural-autoantibodies-in-ugandans-with-rheumatic-heart-disease-and-hiv
#17
Daniel M Huck, Emmy Okello, Grace Mirembe, Isaac Ssinabulya, David A Zidar, Gregg J Silverman, Lelise Getu, Amy S Nowacki, Leonard H Calabrese, Robert A Salata, Chris T Longenecker
BACKGROUND: Rheumatic heart disease (RHD) and HIV are prevalent diseases in sub-Saharan Africa, but little is known about their potential interrelationships. The objective of this study was to assess the prevalence of protective natural autoantibodies among patients with RHD in Uganda, and to determine whether the levels of these autoantibodies are affected by HIV status. METHODS: Participants were grouped according to RHD and HIV status. The three control groups (RHD - HIV -, RHD - HIV +, RHD + HIV -) were age-matched to the RHD + HIV + participants...
March 2016: EBioMedicine
https://www.readbyqxmd.com/read/27050445/practice-variation-among-hospitals-in-revascularization-therapy-and-its-association-with-procedure-related-mortality
#18
Jarrod E Dalton, David A Zidar, Belinda L Udeh, Manesh R Patel, Jesse D Schold, Neal V Dawson
BACKGROUND: While substantial practice variation in coronary revascularization has been described and deviation from clinical practice guidelines has been associated with worse outcomes, the degree to which this is driven by flawed decision making and/or appropriate deviation associated with comorbid conditions is unknown. We evaluated heterogeneity in procedure use, and the extent to which hospital-level practice variation is related to surgical mortality. METHODS: We analyzed data on 554,563 inpatients undergoing either percutaneous coronary intervention or coronary artery bypass grafting at 391 centers in 6 states...
June 2016: Medical Care
https://www.readbyqxmd.com/read/26991361/characterization-of-endogenous-sodium-channels-in-the-nd7-23-neuroblastoma-cell-line-implications-for-use-as-a-heterologous-ion-channel-expression-system-suitable-for-automated-patch-clamp-screening
#19
Marc Rogers, Nace Zidar, Danijel Kikelj, Robert W Kirby
The rodent neuroblastoma cell line, ND7-23, is used to express voltage-dependent sodium (Nav) and other neuronal ion channels resistant to heterologous expression in Chinese hamster ovary (CHO) or human embryonic kidney (HEK) cells. Their advantage is that they provide endogenous factors and signaling pathways to promote ion channel peptide folding, expression, and function at the cell surface and are also amenable to automated patch clamping. However, ND7-23 cells exhibit endogenous tetrodotoxin (TTX)-sensitive Nav currents, and molecular profiling has revealed the presence of Nav1...
March 2016: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/26849814/laryngeal-squamous-intraepithelial-lesions-an-updated-review-on-etiology-classification-molecular-changes-and-treatment
#20
Nina Gale, Douglas R Gnepp, Mario Poljak, Primož Strojan, Antonio Cardesa, Tim Helliwell, Robert Šifrer, Metka Volavšek, Ann Sandison, Nina Zidar
Laryngeal carcinogenesis is a multistep process, characterized by an accumulation of genetic changes associated with architectural and cytologic alterations, ranging from squamous hyperplasia to carcinoma in situ and encompassed by the terminology of squamous intraepithelial lesions (SILs). The etiology, classification, genetic changes, and malignant progression of these lesions are reviewed. Tobacco remains the principal etiological factor with gastroesophageal reflux disease recently considered as a possible factor...
March 2016: Advances in Anatomic Pathology
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