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https://www.readbyqxmd.com/read/29753777/surgically-assisted-rapid-palatal-expansion-in-class-iii-malocclusion-our-experience
#1
A Barrabé, C Meyer, H Bonomi, Weber Elise, N Sigaux, A Louvrier
INTRODUCTION: Maxillary transverse deficiency (MTD) is a common facial disharmony that may need surgical assisted rapid palatal expansion (SARPE). The aim of this study was to present our SARPE technique and to report about our experience. MATERIEL AND METHOD: Medical records of all class III patients who underwent SARPE in our department from 2010 to 2015 and for whom a follow-up of at least 1 year was available, were included in a retrospective study. The technic consisted, after short orthodontic preparation allowing for divergence of the upper central incisors, in a complete Le Fort I osteotomy without down fracture, and medial sagittal submucosal separation of the hard palate under general anesthesia in an inpatient procedure...
May 10, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29735529/global-loss-of-leucine-carboxyl-methyltransferase-1-causes-severe-defects-in-fetal-liver-hematopoiesis
#2
Jocelyn A Lee, Zhengqi Wang, Danielle Sambo, Kevin D Bunting, David C Pallas
Leucine Carboxyl Methyltransferase-1 (LCMT-1)3 methylates the carboxy-terminal leucine α-carboxyl group of the catalytic subunits of the protein phosphatase 2A (PP2A) subfamily of protein phosphatases, PP2Ac, PP4c, and PP6c. LCMT-1 differentially regulates the formation and function of a subset of the heterotrimeric complexes that PP2A and PP4 form with their regulatory subunits. Global LCMT-1 knockout causes embryonic lethality in mice, but LCMT-1 function in development is unknown. In the current study, we analyzed the effects of global LCMT-1 loss on embryonic development...
May 7, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29718688/evaluation-and-reduction-of-magnetic-resonance-imaging-artifacts-induced-by-distinct-plates-for-osseous-fixation-an-in-vitro-study-3t
#3
Carsten Rendenbach, Maximilian Schoellchen, Julie Bueschel, Tobias Gauer, Jan Sedlacik, Daniel Kutzner, Pekka K Vallittu, Max Heiland, Ralf Smeets, Jens Fiehler, Susanne Siemonsen
OBJECTIVES: To analyze Magnetic Resonance Imaging (MRI) artifact induced at 3 Tesla by bioresorbable, titanium and glass fiber reinforced composite (GFRC) plates for osseous reconstruction. METHODS: Fixation plates including bioresorbable polymers (Inion CPS, Inion Oy, Tampere, Finland; Rapidsorb, DePuy Synthes, Umkirch, Germany; Resorb X, Gebrueder KLS Martin GmbH, Tuttlingen, Germany), Glass fiber reinforced composite (Skulle Implants Oy, Turku, Finland) and titanium plates of varying thickness and design (DePuy Synthes, Umkirch, Germany) were embedded in agarose gel and a 3T MRI was performed using a standard protocol for head and neck imaging including T1w and T2w sequences...
May 2, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29606318/kleine-levin-syndrome-a-neuropsychiatric-disorder
#4
REVIEW
I Arnulf, E Groos, P Dodet
Kleine-Levin syndrome (KLS) is a rare, relapsing-remitting disease that affects mostly adolescents. It is characterized by episodes lasting from 1 to several weeks, and comprises neurological (hypersomnia, confusion, slowness, amnesia) and neuropsychiatric symptoms (derealization and apathy). Some psychiatric symptoms (megaphagia, hypersexuality, anxiety, depressed mood, hallucinations, delusions) arise during episodes, albeit less frequently, while patients are normal between episodes. However, sudden severe (>18h/day of sleep) and recurrent hypersomnia helps to differentiate KLS from other psychiatric mimics...
March 30, 2018: Revue Neurologique
https://www.readbyqxmd.com/read/29572278/iv-steroids-during-long-episodes-of-kleine-levin-syndrome
#5
Antoine Léotard, Elisabeth Groos, Charlotte Chaumereuil, Laure Peter-Derex, Andrea O Rossetti, Smaranda Leu-Semenescu, Isabelle Arnulf
OBJECTIVE: To retrospectively compare the benefits (episode cessation) and risks of IV methylprednisolone (IV-MP) vs abstention during prolonged Kleine-Levin syndrome (KLS) episodes. METHODS: A total of 26 patients with KLS received 1 g/d IV-MP for 3 days during 1 to 6 episodes each (totaling 43 IV-MP sessions). The change of episode duration with IV-MP (vs previous episode duration) was compared with the change duration between 2 consecutive episodes in 48 untreated patients matched for age, sex, age at KLS onset, number of episodes, and disease duration (more treated than untreated patients had long episodes)...
March 23, 2018: Neurology
https://www.readbyqxmd.com/read/29553974/breathing-abnormalities-during-sleep-in-kleine-levin-syndrome-fact-or-coincidence
#6
Natan Gadoth
PURPOSE OF REVIEW: To highlight and critically discuss the possibility that breathing abnormalities during hypersomnolent episodes are an additional clinical feature of Kleine-Levin Syndrome (KLS). RECENT FINDINGS: A computerized literature search of breathing abnormalities in patients with KLS disclosed two old and a single recent publication describing a total of six patients with sleep apnea during hypersomnolent episodes. SUMMARY: Owing to scarce reports on complete polysomnography during and in-between hypersomnic episodes of KLS, the possibility that breathing abnormalities are an additional clinical feature of this unique episodic sleep syndrome should be further studied...
March 16, 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29536456/the-costa-study-sternal-closure-in-high-risk-patients-a-prospective-randomized-multicenter-trial
#7
Tetyana Leinberger, Claudia Heilmann, Stefan Sorg, Matthias Mueller, Sami Kueri, Claudia Schmoor, Matthias Siepe, Friedhelm Beyersdorf
BACKGROUND:  Median sternotomy in patients with risk factors for wound healing is associated with high rates of postoperative wound infections and sternum instability. METHODS:  A total of 338 patients with elective first median sternotomy and at least four predefined risk factors were randomized between Sternal Talon (Gebrüder Martin GmbH & Co. KG-KLS Martin Group, Tuttlingen, Germany) and wire cerclage. The primary end point was mediastinitis and/or sternal instability within 30 ± 5 days, and the secondary end points were mediastinitis and/or sternal instability within 60 ± 5 days; incidence of pneumonia during hospitalization within the first 30 (±5) days and chest pain intensity...
February 2, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29532411/kleine-levin-syndrome-clues-to-aetiology
#8
REVIEW
Saad Mohammed AlShareef, Richard Mark Smith, Ahmed Salem BaHammam
Kleine-Levin syndrome (KLS) is the commonest recurrent sleep disorder, with a prevalence of 1-2 per million population. Clear diagnostic criteria are now defined, but effective treatment remains elusive. The significant body of published literature allows consideration of possible aetiological mechanisms, an understanding of which could guide the development of therapeutic strategies. Functional imaging studies have been inconclusive; although diencephalic abnormalities are a common finding, no consistent pattern has emerged, and these studies have not revealed the mechanism(s) underlying the development of the abnormalities detected...
March 12, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29436797/a-case-of-kleine-levin-syndrome-diagnostic-and-therapeutic-challenge
#9
Marino Marčić, Ljiljana Marčić, Marina Titlić
Kleine-Levin syndrome (KLS) is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioral and cognitive disturbances, hyperphagia, and in some cases hyper sexuality. Etiology is unknown, and there is no specific clinical or imaging test for this syndrome even though the illness has well-defined clinical features. Also, there is no effective treatment for KLS. KLS is self-limited, so the prognosis for these patients is not so bad. This study presents our case report and comprehensive workout that led to diagnosis which is primarily clinical...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29397778/the-clinical-characteristics-of-kleine-levin-syndrome-according-to-ethnicity-and-geographic-location
#10
Saad M Al Shareef, Aljohara S Almeneessier, Richard M Smith, Ahmed S BaHammam
PURPOSE: Kleine-Levin syndrome (KLS) is a rare, relapsing-remitting, debilitating sleep disorder. Examining KLS characteristics in different ethnic populations may help elucidate the genetic basis of the disorder. No studies have examined KLS in Arabs. Therefore, we compared the clinical characteristics of Saudi Arabian KLS patients to those in other published cohorts to determine whether Arab patients have a distinct phenotype. METHODS: This study included all patients who were diagnosed with KLS at our center between June 2003 and July 2016 (P = 12; Six familial cases)...
February 20, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29346485/adverse-events-in-facial-implant-surgery-and-associated-malpractice-litigation
#11
Hani M Rayess, Peter Svider, Curtis Hanba, Vivek Sagar Patel, Michael Carron, Giancarlo Zuliani
Importance: Facial implants represent an important strategy for providing instant and long-lasting volume enhancement to address both aging and posttraumatic defects. Objective: To better understand risks of facial implants by examining national resources encompassing adverse events and considerations facilitating associated litigation. Design, Setting, and Participants: A cross-sectional study reviewed complications following facial implants...
January 18, 2018: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29332107/the-sleep-architecture-of-saudi-arabian-patients-with-kleine-levin-syndrome
#12
Saad M Al Shareef, Aljohara S Almeneessier, Omeima Hammad, Richard M Smith, Ahmed S BaHammam
To establish baseline sleep architecture during an acute attack of Kleine-Levin syndrome (KLS) in a cohort of Saudi Arabian KLS patients and compare these characteristics with other published cohorts. Methods: This was a retrospective cohort study of the polysomnographic characteristics of 10 typical symptomatic Saudi Arabian KLS patients attending the University Sleep Disorders Center, King Saud University, Riyadh, Saudi Arabia between 2002 and 2015. Data were captured by nocturnal polysomnography during an acute attack of hypersomnia and compared with other published cohorts identified via a systematic literature search...
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29302031/a-non-cell-autonomous-role-for-pml-in-the-maintenance-of-leukemia-from-the-niche
#13
Jlenia Guarnerio, Lourdes Maria Mendez, Noboru Asada, Archita Venugopal Menon, Jacqueline Fung, Kelsey Berry, Paul S Frenette, Keisuke Ito, Pier Paolo Pandolfi
Disease recurrence after therapy, due to the persistence of resistant leukemic cells, represents a fundamental problem in the treatment of leukemia. Elucidating the mechanisms responsible for the maintenance of leukemic cells, before and after treatment, is therefore critical to identify curative modalities. It has become increasingly clear that cell-autonomous mechanisms are not solely responsible for leukemia maintenance. Here, we report a role for Pml in mesenchymal stem cells (MSCs) in supporting leukemic cells of both CML and AML...
January 4, 2018: Nature Communications
https://www.readbyqxmd.com/read/29197416/joint-awareness-in-posttraumatic-osteoarthritis-of-the-knee-validation-of-the-forgotten-joint-score-in-long-term-condition-after-tibial-plateau-fracture
#14
Florian Baumann, Johannes Weber, Daniel Mahr, Martin Bäumlein, Maximilian Kerschbaum, Karolina Müller, Paavo Rillmann, Michael Nerlich, Markus Loibl
BACKGROUND: Evaluating patient-reported outcomes (PRO) in early osteoarthritis (OA) of the knee is difficult. Established measurement tools are focused on one of the two major patient groups in knee surgery: young, highly active patients, or older patients with advanced degenerative OA of the knee. Joint awareness in everyday life is a crucial criterion in measuring PRO. The purpose of this study was to validate a German version of the "Forgotten Joint Score" (FJS) in patients after surgical treatment of tibial plateau fractures...
December 2, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29026774/atypical-kleine-levin-syndrome-an-elusive-entity
#15
Swarndeep Singh, Saurabh Kumar, Rohit Verma, Nand Kumar
Kleine-Levin syndrome (KLS) is a rare disorder (around 1.5 cases per million population), often presenting with triad of recurrent episodes of hypersomnia, hyperphagia, and hypersexuality. However, cases of atypical KLS with features opposite to that being commonly reported are often misdiagnosed as psychosis and present as a diagnostic challenge for the physicians, psychiatrists, and neurologists. We describe a case of atypical KLS which was misdiagnosed as unspecified nonorganic psychosis previously, highlighting the various points which would be helpful in identifying and diagnosing cases of atypical KLS in future...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28852256/successful-long-term-management-of-a-child-with-kleine-levin-syndrome-with-low-dose-lithium
#16
Arpit Parmar, Priyanka Yadav, Bichitra Nanda Patra, Rajesh Sagar
Kleine-Levin syndrome (KLS) is a rare disorder characterized by episodic hypersomnia along with cognitive and behavioral disturbances (i.e., hyperphagia and hypersexuality). It is commonly seen in a young male. Not much is known about its long-term management; however, many reports suggest the usefulness of anticonvulsants and lithium for the same. We hereby report a case of childhood KLS from India who was successfully treated with low-dose lithium and discuss the relevant literature.
July 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28721990/neocondyle-distraction-osteogenesis-in-the-management-of-temporomandibular-joint-ankylosis-report-of-five-cases-with-review-of-literature
#17
Ravi Sharma, R Manikandhan, P Sneha, Anantanarayanan Parameswaran, J Naveen Kumar, Hermann F Sailer
INTRODUCTION AND OBJECTIVES: Management of temporomandibular joint (TMJ) ankylosis is a challenging and rather daunting task owing to complex abnormal anatomy and its sequel to craniofacial structures. Various autogenous grafts and alloplastic materials have been tried with variable success for creation of a near-normal joint. In recent years, neocondyle distraction has added a new dimension to the management of TMJ ankylosis. The aim of this paper is to describe the role of neocondyle distraction in TMJ ankylosis...
May 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28710861/differential-protein-modulation-by-ketoprofen-and-ibuprofen-underlines-different-cellular-response-by-gastric-epithelium
#18
COMPARATIVE STUDY
Laura Brandolini, Michele d'Angelo, Andrea Antonosante, Sara Villa, Loredana Cristiano, Vanessa Castelli, Elisabetta Benedetti, Mariano Catanesi, Andrea Aramini, Alberto Luini, Seetharaman Parashuraman, Emilia Mayo, Antonio Giordano, Annamaria Cimini, Marcello Allegretti
Ketoprofen L-lysine salt (KLS), is widely used due to its analgesic efficacy and tolerability, and L-lysine was reported to increase the solubility and the gastric tolerance of ketoprofen. In a recent report, L-lysine salification has been shown to exert a gastroprotective effect due to its specific ability to counteract the NSAIDs-induced oxidative stress and up-regulate gastroprotective proteins. In order to derive further insights into the safety and efficacy profile of KLS, in this study we additionally compared the effect of lysine and arginine, another amino acid counterion commonly used for NSAIDs salification, in control and in ethanol challenged human gastric mucosa model...
March 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28615776/sleeping-beauty-syndrome-a-case-report-and-review-of-female-cases-reported-from-india
#19
Naresh Nebhinani, Navratan Suthar
Kleine-Levin syndrome (KLS), also called "Sleeping beauty syndrome" is a rare, disorder predominantly reported in adolescent males, characterized by recurrent episodes of hypersomnia and to various degrees, hyperphagia, cognitive disturbances, and hypersexuality. Here, we are reporting a case of a middle-aged female, with 16 years delay in diagnosing KLS, poor response to most of the psychotropics, except good response to a combination of lithium, sertraline, and modafinil for last 12 months and also reviewing other female cases with KLS reported from India...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28493922/comparison-of-the-long-term-clinical-performance-of-a-biodegradable-and-a-titanium-fixation-system-in-maxillofacial-surgery-a-multicenter-randomized-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
B Gareb, N B van Bakelen, G J Buijs, J Jansma, J G A M de Visscher, Th J M Hoppenreijs, J E Bergsma, B van Minnen, B Stegenga, R R M Bos
BACKGROUND: Biodegradable fixation systems could reduce or eliminate problems associated with titanium removal of implants in a second operation. AIM: The aim of this study was to compare the long-term (i.e. >5 years postoperatively) clinical performance of a titanium and a biodegradable system in oral and maxillofacial surgery. MATERIALS AND METHODS: The present multicenter Randomized Controlled Trial (RCT) was performed in four hospitals in the Netherlands...
2017: PloS One
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