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https://www.readbyqxmd.com/read/29775758/lncrna-prncr1-regulates-osteogenic-differentiation-in-osteolysis-after-hip-replacement-by-targeting-mir-211-5p
#1
Zong-Ming Gong, Zhen-Yu Tang, Xiao-Liang Sun
BACKGROUND: Osteogenic differentiation and osteolysis after hip replacement are both associated with bone metabolism. Interaction between lncRNA PRNCR1 and miR-211-5p was analyzed to illuminate their roles in osteogenic differentiation and osteolysis. METHODS: The expression of PRNCR1, miR-211-5p and C-X-C chemokine receptor-4 (CXCR4) protein in tissues and mesenchymal stem cells (MSCs) were determined by qRT-PCR and Western blot, separately. The osteogenic differentiation was assessed by ALP activity detection and ARS staining...
May 15, 2018: Gene
https://www.readbyqxmd.com/read/29774901/hierarchical-nanopores-formed-by-block-copolymer-lithography-on-the-surfaces-of-different-materials-pre-patterned-by-nanosphere-lithography
#2
Katharina Brassat, Daniel Kool, Julius Bürger, Jörg K N Lindner
Bottom-up patterning techniques allow for the creation of surfaces with ordered arrays of nanoscale features on large areas. Two bottom-up techniques suitable for the formation of regular nanopatterns on different length scales are nanosphere lithography (NSL) and block copolymer (BCP) lithography. In this paper it is shown that NSL and BCP lithography can be combined to easily design hierarchically nanopatterned surfaces of different materials. Nanosphere lithography is used for the pre-patterning of surfaces with antidots, i...
May 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29770769/ct-fluoroscopy-guided-percutaneous-osteoplasty-with-or-without-radiofrequency-ablation-in-the-treatment-of-painful-extraspinal-and-spinal-bone-metastases-technical-outcome-and-complications-in-29-patients
#3
Caroline A Burgard, Julien Dinkel, Frederik Strobl, Philipp M Paprottka, Nicolai Schramm, Maximilian Reiser, Christoph G Trumm
PURPOSE: We aimed to assess the safety and technical outcome of computed tomography (CT) fluoroscopy-guided osteoplasty with or without prior percutaneous radiofrequency ablation (RFA) in patients with painful osteolyses. METHODS: We performed a retrospective analysis of 29 patients with painful extraspinal and spinal osteolyses (16 women, 13 men; 63.1±14.4 years) who underwent CT fluoroscopy-guided osteoplasty (10-20 mAs tube current) with or without RFA (26 and 14 lesions, respectively), in 33 consecutive procedures from 2002 to 2016...
May 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29768830/strong-hydrogen-bonding-with-inorganic-pendant-polyhedral-oligomeric-silsesquioxane-nanoparticles-provides-high-glass-transition-temperature-poly-methyl-methacrylate-copolymers
#4
Shu-Ling Yeh, Chao-Yuan Zhu, Shiao-Wei Kuo
We report a series of poly(methyl methacrylate) (PMMA) copolymers containing small amounts of methacrylamide (MAAM) and pendant polyhedral oligomeric silsesquioxane (POSS) methyl acrylate (MAPOSS) segments. The hydrogen bonding interactions of the MAAM monomer units and the inorganic POSS nanoparticle units improved the thermal and mechanical properties of the PMMA copolymers. For example, PMMA copolymerization with 5 wt% PMAAM and 5 wt% PMAPOSS monomers could enhance the glass transition temperature to 142°C, with higher modulus, higher water contact angle, and reasonably high transparency...
January 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29768010/highly-sensitive-electromechanical-piezoresistive-pressure-sensors-based-on-large-area-layered-ptse2-films
#5
Stefan Wagner, Chanyoung Yim, Niall McEvoy, Satender Kataria, Volkan Yokaribas, Agnieszka Kuc, Stephan Pindl, Claus-Peter Fritzen, Thomas Heine, Georg S Duesberg, Max C Lemme
Two-dimensional (2D) layered materials are ideal for micro- and nanoelectromechanical systems (MEMS/NEMS) due to their ultimate thinness. Platinum diselenide (PtSe2 ), an exciting and unexplored 2D transition metal dichalcogenides (TMD) material, is particularly interesting because its scalable and low temperature growth process is compatible with silicon technology. Here, we explore the potential of thin PtSe2 films as electromechanical piezoresistive sensors. All experiments have been conducted with semi-metallic PtSe2 films grown by thermally assisted conversion of Pt at a CMOS-compatible temperature of 400°C...
May 16, 2018: Nano Letters
https://www.readbyqxmd.com/read/29766617/gingival-tissue-reaction-to-direct-adhesive-restoration-a-preliminary-study
#6
Carlo Bertoldi, Davide Zaffe, Luigi Generali, Andrea Lucchi, Pierpaolo Cortellini, Emanuela Monari
INTRODUCTION: It is debated if composite resin marginal/submarginal direct restoration can be usefully performed without inflammatory consequences. This histological study is the first human analysis aimed to compare, in the same tooth, the gingival tissue close to composite resin restorations with gingival tissue close to hard tissue. METHODS: Eight healthy patients with almost a residual strategic tooth needing endodontic therapy, and post-and-core restoration, then indirect prosthetic restoration, were selected...
May 16, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29766202/photochemical-device-for-selective-detection-of-phenol-in-aqueous-solutions
#7
Nianbing Zhong, Ming Chen, Zhengkun Wang, Xin Xin, Bingxin Li
We demonstrate that a lab-on-a-chip device (hereafter termed a photochemical phenol sensor) that integrates a photocatalytic long-period fiber grating (PLPFG), fiber Bragg grating (FBG), polymer membrane, ultraviolet (UV) visible light, and microchannels can be exploited to selectively detect phenol in aqueous solutions. The novel PLPFG consisted of a thinned long-period fiber grating (LPFG) and a UV-visible-light-driven Er3+:YAlO3/SiO2/TiO2 (EYST) coating. The polymer membrane with high phenol permselectivity was synthesized using PEBA2533 doped with β-cyclodextrin and was wrapped around the EYST surface, thus forming a microchannel between the membrane and PLPFG to enable the injection and outflow of standard analytes...
May 16, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29764470/joint-preserving-palliative-surgery-using-self-locking-screws-of-intramedullary-nail-and-percutaneous-cementoplasty-for-proximal-humeral-metastasis-in-the-advanced-cancer-patients
#8
Jong Woong Park, Yong-Il Kim, Hyun Guy Kang, June Hyuk Kim, Han Soo Kim
BACKGROUND: We introduced a palliative joint-preserving surgery using proximal self-locking screws of intramedullary (IM) nail and percutaneous cementoplasty (PC) in patients with proximal humeral metastases, including the head and neck, and evaluated the outcome of the surgical method. METHODS: Twenty-three patients (mean age = 63.0 ± 11.8 years, M:F = 14:9) had IM nailing with a self-locking screw system and PC for the treatment of humeral head and neck metastases...
May 15, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29764200/copper-release-rate-needed-to-inhibit-fouling-on-the-west-coast-of-sweden-and-control-of-copper-release-using-zinc-oxide
#9
J Fredrik Lindgren, Erik Ytreberg, Albin Holmqvist, Magnus Dahlström, Peter Dahl, Mattias Berglin, Anna-Lisa Wrange, Mia Dahlström
How zinc oxide influences copper release has been tested and the lowest release rate of copper from various combinations of copper and zinc in a paint matrix evaluated, whilst still deterring macrofouling, including barnacles and bryozoans. Copper (I) oxide was added to a generic AF paint in 0, 8.5, 11.7 or 16.3 wt% copper oxide in combination with 0, 10 or 20 wt% zinc oxide and applied on PMMA panels. The results show that zinc influences the release rate of copper. When 10 and 20 wt% zinc was added, the total amount of copper released significantly increased by on average 32 and 47% respectively...
May 15, 2018: Biofouling
https://www.readbyqxmd.com/read/29763970/technical-note-experimental-verification-of-magnetic-field-induced-beam-deflection-and-bragg-peak-displacement-for-mr-integrated-proton-therapy
#10
Sonja M Schellhammer, Sebastian Gantz, Armin Lühr, Bradley M Oborn, Michael Bussmann, Aswin L Hoffmann
PURPOSE: Given its sensitivity to anatomical variations, proton therapy is expected to benefit greatly from integration with magnetic resonance imaging for on-line anatomy monitoring during irradiation. Such an integration raises several challenges, as both systems mutually interact. The proton beam will experience quasi-continuous energy loss and energy-dependent electromagnetic deflection at the same time, giving rise to a deflected beam trajectory and an altered dose distribution with a displaced Bragg peak...
May 15, 2018: Medical Physics
https://www.readbyqxmd.com/read/29761567/cyclometalated-nhcs-and-pyrazoles-with-starring-roles-for-developing-fully-efficient-blue-pt-ii-emitters-and-pt-ag-clusters
#11
Violeta Sicilia, Lorenzo Arnal, Sara Fuertes, Antonio Martín
New bis-pyrazole complexes [Pt(C^C*)(RpzH)2]X, containing a cyclometalated N-heterocyclic carbene ligand (HC^C* = 1-(4-(ethoxycarbonyl)phenyl)-3-methyl-1H-imidazol-2-ylidene) were prepared as chloride (X = Cl-, RpzH: 3,5-Me2pzH 1a, 4-MepzH 2a, pzH 3a), perchlorate (X = ClO4-,1b  3b), or hexafluorophosphate (X = PF6-, RpzH: 3,5-Me2pzH 1c) salts. The X-ray structure of 1a showed that the Cl- anion is trapped by the cation through two N-H***Cl bonds. In solution of methanol, acetone and THF at r.t. 1a-3a, coexist in equilibrium with the corresponding [PtCl(C^C*)(RpzH)](B) and RpzH species...
May 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29761236/different-pedicle-osteosynthesis-for-thoracolumbar-vertebral-fractures-in-elderly-patients
#12
Massimo Girardo, Alessandro Rava, Federico Fusini, Giosuè Gargiulo, Angela Coniglio, Pasquale Cinnella
INTRODUCTION: Pedicle screws' stability, especially in osteoporotic fractures, is a really problem for spinal surgeons. Nowadays, little is known about the influence of different screw types and amount of cement applied. This single-center retrospective observational study has the aim of evaluating the middle- to long-term mechanical performances of different types of screws in elderly patients with thoracolumbar fractures. MATERIALS AND METHODS: A total of 91 patients (37 males and 54 females), treated between 2011 and 2016, affected by somatic osteoporotic fractures aged over 65 years were treated...
May 14, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29761068/antibiotic-containing-bone-substitute-in-major-hip-surgery-a-long-term-gentamicin-elution-study
#13
Mindaugas Stravinskas, Malin Nilsson, Peter Horstmann, Michael Mørk Petersen, Sarunas Tarasevicius, Lars Lidgren
Objectives: The objective is to present the antibiotic elution from a locally implanted gentamicin containing hydroxyapatite and calcium sulphate bone substitute with an extended follow up of 30 days. We also compare the pharmacokinetics of the ceramic bone substitute with a published study on gentamicin containing poly (methyl methacrylate) (PMMA) bone cement used in primary total hip arthroplasty. Methods: Gentamicin release was measured in the urine for a month and the serum for 4 days in 10 patients operated for trochanteric hip fractures and 10 patients in uncemented hip revisions...
2018: Journal of Bone and Joint Infection
https://www.readbyqxmd.com/read/29752342/lncrna-prncr1-regulates-osteogenic-differentiation-in-osteolysis-after-hip-replacement-by-targeting-mir-211-5p
#14
Zong-Ming Gong, Zhen-Yu Tang, Xiao-Liang Sun
Background Osteogenic differentiation and osteolysis after hip replacement are both associated with bone metabolism. Interaction between the long non-coding RNA (lncRNA) prostate cancer non-coding RNA 1 (PRNCR1) and miR-211-5p was analyzed to illuminate their roles in osteogenic differentiation and osteolysis. Methods The expression of PRNCR1, miR-211-5p and C-X-C chemokine receptor-4 (CXCR4) protein in tissues and mesenchymal stem cells (MSCs) were determined by qRT-PCR and western blot, separately. The osteogenic differentiation was assessed with Alkaline phosphatase (ALP) activity detection and ARS staining...
May 11, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29752107/macroporous-microbeads-containing-apatite-modified-mesoporous-bioactive-glass-nanofibres-for-bone-tissue-engineering-applications
#15
Fu-Yin Hsu, Hsien-Wen Hsu, Yu-Han Chang, Jing-Lun Yu, Lih-Rou Rau, Shiao-Wen Tsai
Mesoporous bioactive glass (MBG) has a greater surface area and pore volume than conventional BG. Hence, MBG is useful as a drug delivery carrier. Previously, MBG has been fabricated as dense or porous blocks. Compared to blocks, microbeads have a greater flexibility to fill different-shaped cavities with close packing. Moreover, fibrous materials have proven to increase cell attachment and differentiation because they mimic the three-dimensional structure of the natural extracellular matrix (ECM). Macroporous materials possess porous structures with interconnecting channels that allow the invasive growth of cells and capillaries...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29747619/clinical-results-of-the-open-ring-pmma-guider-assisted-capsulorrhexis-in-cataract-surgery
#16
Jee Hye Lee, Yong Eun Lee, Choun-Ki Joo
BACKGROUND: To compare the results of continuous curvilinear capsulorrhexis(CCC) after application of an open ring-shaped guider compared with a free-hand procedure in eyes with cataracts. METHODS: This study comprised patients undergoing cataract surgery in Seoul St.Mary's Hospital, The Catholic University of Korea. Eyes were grouped depending on the capsulotomy method; CCC was performed by free-hand procedure on 94 eyes (free-hand group), and it was performed under the guidance after introduction of an open ring-shaped guider on consecutive 89 eyes (guided group)...
May 10, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29745645/spray-coating-thin-films-on-three-dimensional-surfaces-for-a-semi-transparent-capacitive-touch-device
#17
Tian Carey, Chris Jones, Fred Le Moal, Davide Deganello, Felice Torrisi
Here we formulate low surface tension (~ 30 mN/m) and low boiling point (~ 79 °C) inks of graphene, single wall carbon nanotubes (SWNTs) and conductive polymer poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS) and demonstrate their viability for spray-coating of morphologically uniform (Sq ~ 48 ± 3 nm), transparent conducting films (TCFs) at room temperature (~ 20 °C), which conform to three dimensional (3D) curved surfaces. Large area (~ 750 cm2 ) hybrid PEDOT:PSS/graphene films achieved an optical transmission of 67% in the UV and 64% in the near-infrared (n-IR) wavelengths with a conductivity of ~104 S/m...
May 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29744453/studies-on-the-cytocompatibility-mechanical-and-antimicrobial-properties-of-3d-printed-poly-methyl-methacrylate-beads
#18
David K Mills, Uday Jammalamadaka, Karthik Tappa, Jeffery Weisman
Osteomyelitis is typically a bacterial infection (usually from Staphylococcus) or, more rarely, a fungal infection of the bone. It can occur in any bone in the body, but it most often affects the long bones (leg and arm), vertebral (spine), and bones of the foot. Microbial success in osteomyelitis is due to their ability to form biofilms which inhibit the wound healing process and increases resistance to anti-infective agents. Also, biofilms do not allow easy penetration of antibiotics into their matrix making clinical treatment a challenge...
June 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29744425/preliminary-focus-on-the-mechanical-and-antibacterial-activity-of-a-pmma-based-bone-cement-loaded-with-gold-nanoparticles
#19
T Russo, A Gloria, R De Santis, U D'Amora, G Balato, A Vollaro, O Oliviero, G Improta, M Triassi, L Ambrosio
In total knee arthroplasty (TKA) and total hip replacement (THR) the restoration of the normal joint function represents a fundamental feature. A prosthetic joint must be able to provide motions and to transmit functional loads. As reported in the literature, the stress distribution may be altered in bones after the implantation of a total joint prosthesis. Some scientific works have also correlated uncemented TKA to a progressive decrease of bone density below the tibial component. Antibiotic-loaded bone cements are commonly employed in conjunction with systemic antibiotics to treat infections...
September 2017: Bioactive Materials
https://www.readbyqxmd.com/read/29740096/transition-from-spin-dewetting-to-continuous-film-in-spin-coating-of-liquid-crystal-5cb
#20
Palash Dhara, Nandini Bhandaru, Anuja Das, Rabibrata Mukherjee
Spin dewetting refers to spontaneous rupture of the dispensed solution layer during spin coating, resulting in isolated but periodic, regular sized domains of the solute and is pre-dominant when the solute concentration (C n ) is very low. In this article we report how the morphology of liquid crystal (LC) 5CB thin films coated on flat and patterned PMMA substrate transform from spin dewetted droplets to continuous films with increase in C n . We further show that within the spin dewetted regime, with gradual increase in the solute concentration, periodicity of the isotropic droplets (λ D ) as well as their mean diameter (d D ), gradually decreases, till the film becomes continuous at a critical concentration (C n *)...
May 8, 2018: Scientific Reports
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