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Cardiac hypertrophy

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https://www.readbyqxmd.com/read/29912308/metabolic-changes-in-hypertrophic-cardiomyopathies-scientific-update-from-the-working-group-of-myocardial-function-of-the-european-society-of-cardiology
#1
Jolanda van der Velden, Carlo Gabriele Tocchetti, Gilda Varricchi, Anna Bianco, Vasco Sequeira, Denise Hilfiker-Kleiner, Nazha Hamdani, Adelino Leite-Moreira, Manuel Mayr, Ines Falcão-Pires, Thomas Thum, Dana K Dawson, Jean-Luc Balligand, Stephane Heymans
Disturbed metabolism as a consequence of obesity and diabetes may cause cardiac diseases (recently highlighted in the CVR spotlight issue on Metabolic cardiomyopathies).1 In turn, the metabolism of the heart may also be disturbed in genetic and acquired forms of hypertrophic cardiac disease. Here, we provide an overview of recent insights on metabolic changes in genetic hypertrophic cardiomyopathy (HCM) and discuss several therapies which may be explored to target disturbed metabolism and prevent onset of cardiac hypertrophy...
June 15, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29911451/effect-of-well-controlled-gestational-diabetes-on-left-ventricular-diastolic-dysfunction-in-neonates
#2
Yazdan Ghandi, Danial Habibi, Khadijeh Nasri, Saeed Alinejad, Hassan Taherahmad, Ali Arjmand Shabestari, Ali Nematinejad
BACKGROUND: There are some evidences supporting the relation between gestational diabetes mellitus (GDM) and diastolic dysfunction. The aim of our study was to investigate the effect of well-controlled GDM on morphological and functional myocardium. MATERIALS AND METHODS: We designed a prospective cross-sectional study to evaluate left ventricular (LV) diastolic function of 60 neonates born from mothers with well-controlled GDM (case group) on days of 3-5 after birth...
June 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29910224/contemporary-septal-reduction-therapy-in-drug-refractory-hypertrophic-obstructive-cardiomyopathy
#3
Yuichiro Maekawa, Keitaro Akita, Shuichiro Takanashi
Hypertrophic cardiomyopathy (HCM) is a complex and relatively common genetic cardiac disease that has been the subject of intense investigation for over 50 years. Most patients with HCM are asymptomatic, but some develop symptoms, often many years after the appearance of electrocardiographic or echocardiographic evidence of left ventricular hypertrophy. Symptoms due to the left ventricular outflow tract obstruction frequently worsen over time, requiring septal reduction therapy (SRT) despite optimal medical therapy...
June 15, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29909753/alteration-at-transcriptional-level-of-cardiac-renin-angiotensin-system-by-letrozole-treatment
#4
Shahnaz Shekarforoush, Farhad Koohpeyma, Fatemeh Safari
INTRODUCTION: The use of aromatase inhibitors (AIs) for breast cancer led to a marked change in ventricular function. Since accumulating evidence indicates that overactivation of the cardiac renin-angiotensin system (RAS) plays an important role in the development of cardiovascular diseases such as hypertrophy and remodelling, we aimed to investigate whether letrozole alters the transcription level of RAS related genes in the cardiac tissue. METHODS: Twenty four rats were randomly divided into four groups (n = 6 per group): two groups were letrozole treated (1 and 2 mg/kg/day orally), one group was vehicle treated (DMSO) and one group was the control group without any treatment...
June 17, 2018: Acta Cardiologica
https://www.readbyqxmd.com/read/29909504/anderson-fabry-disease-in-heart-failure
#5
REVIEW
M M Akhtar, P M Elliott
Anderson-Fabry disease is an X-linked lysosomal storage disorder caused by mutations in the GLA gene that result in deficiency of the enzyme alpha-galactosidase A. The worldwide incidence of Fabry's disease is reported to be in the range of 1 in 40,000-117,000, although this value may be a significant underestimate given under recognition of symptoms and delayed or missed diagnosis. Deficiency in alpha-galactosidase A causes an accumulation of neutral glycosphingolipids such as globotriaosylceramide (Gb3) in lysosomes within various tissues including the vascular endothelium, kidneys, heart, eyes, skin and nervous system...
June 16, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29908829/pre-hypertension-and-subclinical-cardiac-damage-a-meta-analysis-of-echocardiographic-studies
#6
Cesare Cuspidi, Carla Sala, Marijana Tadic, Elisa Gherbesi, Guido Grassi, Giuseppe Mancia
AIM: The association between pre-hypertension (pre-HTN) and subclinical cardiac damage remains undefined. We performed a systematic meta-analysis of echocardiographic studies in order to provide a comprehensive information on structural and functional cardiac changes in untreated pre-HTN subjects. DESIGN: Studies were identified by crossing the following search terms: "pre-hypertension", "high normal blood pressure" "heart" "left ventricular hypertrophy", "left ventricular function", "diastolic function", "left atrial size", "aortic root size", "echocardiography...
June 8, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29902536/aldolase-promotes-the-development-of-cardiac-hypertrophy-by-targeting-ampk-signaling
#7
Yapeng Li, Dianhong Zhang, Lingyao Kong, Huiting Shi, Xinyu Tian, Lu Gao, Yuzhou Liu, Leiming Wu, Binbin Du, Zhen Huang, Cui Liang, Zheng Wang, Rui Yao, Yanzhou Zhang
Metabolic dysfunction is a hallmark of cardiac hypertrophy and heart failure. During cardiac failure, the metabolism of cardiomyocyte switches from fatty acid oxidation to glycolysis. However, the roles of key metabolic enzymes in cardiac hypertrophy are not understood fully. Here in the present work, we identified Aldolase A (AldoA) as a core regulator of cardiac hypertrophy. The mRNA and protein levels of AldoA were significantly up-regulated in transverse aortic constriction (TAC)- and isoproterenol (ISO)-induced hypertrophic mouse hearts...
June 11, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29901150/n%C3%A2-terminal-truncated-peroxisome-proliferator%C3%A2-activated-receptor%C3%A2-%C3%AE-coactivator%C3%A2-1%C3%AE-alleviates-phenylephrine%C3%A2-induced-mitochondrial-dysfunction-and-decreases-lipid-droplet-accumulation-in-neonatal-rat-cardiomyocytes
#8
Zuheng Liu, Jinghai Hua, Wanqiang Cai, Qiong Zhan, Wenyan Lai, Qingchun Zeng, Hao Ren, Dingli Xu
N‑terminal truncated peroxisome proliferator‑activated receptor‑γ coactivator‑1α (NT‑PGC‑1α) is an alternative splice variant of PGC‑1α. NT‑PGC‑1α exhibits stronger anti‑obesity effects in adipose tissue than PGC‑1α; however, NT‑PGC‑1α has not yet been investigated in neonatal rat cardiomyocytes (NRCMs). The present study aimed to investigate the role of NT‑PGC‑1α in mitochondrial fatty acid metabolism and its possible regulatory mechanism in NRCMs. NRCMs were exposed to phenylephrine (PE) or angiotensin II (Ang II) to induce cardiac hypertrophy...
June 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29900299/dataset-on-the-use-of-3d-speckle-tracking-echocardiography-in-light-chain-amyloidosis
#9
Antonio Vitarelli, Maria Teresa Petrucci, Silvia Lai, Carlo Gaudio, Lidia Capotosto, Enrico Mangieri, Serafino Ricci, Simone De Sio, Giovanni Truscelli, Federico Vozella, Mario Sergio Pergolini
The dataset presented in this article is related to the research article entitled "Biventricular assessment of light-chain amyloidosis using 3D speckle tracking echocardiography: Differentiation from other forms of myocardial hypertrophy" (Vitarelli et al., 2018) [1], which examined the potential utility of left ventricular (LV) and right ventricular (RV) deformation and rotational parameters derived from three-dimensional speckle-tracking echocardiography (3DSTE) to diagnose cardiac amyloidosis(CA) and differentiate this disease from other forms of myocardial hypertrophy...
June 2018: Data in Brief
https://www.readbyqxmd.com/read/29895976/an-essential-role-for-wnt-%C3%AE-catenin-signaling-in-mediating-hypertensive-heart-disease
#10
Yue Zhao, Chunhong Wang, Cong Wang, Xue Hong, Jinhua Miao, Yulin Liao, Lili Zhou, Youhua Liu
Activation of the renin-angiotensin system (RAS) is associated with hypertension and heart disease. However, how RAS activation causes cardiac lesions remains elusive. Here we report the involvement of Wnt/β-catenin signaling in this process. In rats with chronic infusion of angiotensin II (Ang II), eight Wnt ligands were induced and β-catenin activated in both cardiomyocytes and cardiac fibroblasts. Blockade of Wnt/β-catenin signaling by small molecule inhibitor ICG-001 restrained Ang II-induced cardiac hypertrophy by normalizing heart size and inhibiting hypertrophic marker genes...
June 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29895484/coping-and-cardiac-troponin-t-a-risk-for-hypertension-and-sub-clinical-ecg-left-ventricular-hypertrophy-the-sabpa-study
#11
Catharina Elizabeth Myburgh, Leoné Malan, Annemarie Wentzel, Jacobus De Wet Scheepers, Nicolaas Theodor Malan
BACKGROUND: Defensive coping (DefS) was associated with cardiovascular disease (CVD) susceptibility in Blacks. Whether coping strategies will associate with sub-clinical left ventricular hypertrophy (electrocardiographic-left ventricular hypertrophy [ECG-LVH] or Cornell product), cardiomyocyte injury and blood pressure (BP), is unclear. Therefore, we assessed relationships between ECG-LVH, cardiac troponin T (cTnT) and 24-hour BP in bi-ethnic groups when habitually utilising a certain coping style, and these groups when having a stress-related cTnT cut-point of 4...
May 31, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29893985/-management-of-hypertrophic-cardiomyopathy-the-most-common-inherited-heart-disease
#12
Peter Magnusson, Fredrik Gadler, Stellan Mörner
Hypertrophic cardiomyopathy is the most common cardiogenetic disease affecting 1/500-1/1 000 individuals. Dyspnea is common but chest pain, dizziness or fainting may also cause considerable limitation for the patient. The diagnosis can be suspected from ECG. Echocardiography confirms hypertrophy of at least 15 mm, usually in the septum. If the obstruction of the outflow tract is severe, myectomy or alcohol ablation can relieve symptoms. Genetic evaluation of family members is advisable. To reduce symptoms, betablockers are used; verapamil or disopyramide are alternatives...
June 11, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29893180/potential-adverse-cardiac-remodelling-in-highly-trained-athletes-still-unknown-clinical-significance
#13
Luigi Gabrielli, Marta Sitges, Mario Chiong, Jorge Jalil, María Ocaranza, Silvana Llevaneras, Sebastian Herrera, Rodrigo Fernandez, Rodrigo Saavedra, Fernando Yañez, Luis Vergara, Alexis Diaz, Sergio Lavandero, Pablo Castro
Moderate endurance exercise has long been considered an essential element to maintain cardiovascular health, and sedentary behaviour in the general population has been related to a significant increase in all-causes of mortality, cardiovascular disease mortality and cardiovascular disease incidence. However, a growing group of people performs an intense exercise that leads to multiple heart adaptive changes that are collectively called "athlete's heart". In this review, we discussed the evidence of cardiac remodelling process secondary to repetitive and strenuous exercise in some predisposed athletes that produces intense and probably deleterious changes in cardiac morphology and function with no clear clinical significance in long-term follow-up...
June 12, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29892269/paracrine-effects-of-fgf23-on-the-heart
#14
REVIEW
Maren Leifheit-Nestler, Dieter Haffner
Fibroblast growth factor (FGF) 23 is a phosphaturic hormone primarily secreted by osteocytes to maintain phosphate and mineral homeostasis. In patients with and without chronic kidney disease, enhanced circulating FGF23 levels associate with pathologic cardiac remodeling, i.e., left ventricular hypertrophy (LVH) and myocardial fibrosis and increased cardiovascular mortality. Experimental studies demonstrate that FGF23 promotes hypertrophic growth of cardiac myocytes via FGF receptor 4-dependent activation of phospholipase Cγ/calcineurin/nuclear factor of activated T cell signaling independent of its co-receptor klotho...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29892230/loss-of-akap1-exacerbates-pressure-overload-induced-cardiac-hypertrophy-and-heart-failure
#15
Gabriele G Schiattarella, Nicola Boccella, Roberta Paolillo, Fabio Cattaneo, Valentina Trimarco, Anna Franzone, Stefania D'Apice, Giuseppe Giugliano, Laura Rinaldi, Domenica Borzacchiello, Alessandra Gentile, Assunta Lombardi, Antonio Feliciello, Giovanni Esposito, Cinzia Perrino
Left ventricular hypertrophy (LVH) is a major contributor to the development of heart failure (HF). Alterations in cyclic adenosine monophosphate (cAMP)-dependent signaling pathways participate in cardiomyocyte hypertrophy and mitochondrial dysfunction occurring in LVH and HF. cAMP signals are received and integrated by a family of cAMP-dependent protein kinase A (PKA) anchor proteins (AKAPs), tethering PKA to discrete cellular locations. AKAPs encoded by the Akap1 gene (mitoAKAPs) promote PKA mitochondrial targeting, regulating mitochondrial structure and function, reactive oxygen species production, and cell survival...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29891738/expression-and-implication-of-clusterin-in-left-ventricular-remodeling-after-myocardial-infarction
#16
Annie Turkieh, Marie Fertin, Marion Bouvet, Paul Mulder, Hervé Drobecq, Gilles Lemesle, Nicolas Lamblin, Pascal de Groote, Sina Porouchani, Maggy Chwastyniak, Olivia Beseme, Philippe Amouyel, Frédéric Mouquet, Jean-Luc Balligand, Vincent Richard, Christophe Bauters, Florence Pinet
BACKGROUND: Left ventricular remodeling (LVR) after myocardial infarction is associated with an increased risk of heart failure and death. In spite of a modern therapeutic approach, LVR remains relatively frequent and difficult to predict in clinical practice. Our aim was to identify new biomarkers of LVR and understand their involvement in its development. METHODS AND RESULTS: Proteomic analysis of plasma from the REVE-2 study (Remodelage Ventriculaire)-a study dedicated to the analysis of LVR which included 246 patients after a first anterior myocardial infarction-identified increased plasma levels of CLU (clusterin) in patients with high LVR...
June 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29891648/hypoxia-induced-mitogenic-factor-promotes-cardiac-hypertrophy-via-calcium-dependent-and-hypoxia-inducible-factor-1%C3%AE-mechanisms
#17
Santosh Kumar, Gang Wang, Wenjuan Liu, Wenwen Ding, Ming Dong, Na Zheng, Hongyu Ye, Jie Liu
HIMF (hypoxia-induced mitogenic factor/found in inflammatory zone 1/resistin like α) is a secretory and cytokine-like protein and serves as a critical stimulator of hypoxia-induced pulmonary hypertension. With a role for HIMF in heart disease unknown, we explored the possible roles for HIMF in cardiac hypertrophy by overexpressing and knocking down HIMF in cardiomyocytes and characterizing HIMF gene ( himf ) knockout mice. We found that HIMF mRNA and protein levels were upregulated in phenylephrine-stimulated cardiomyocyte hypertrophy and our mouse model of transverse aortic constriction-induced cardiac hypertrophy, as well as in human hearts with dilated cardiomyopathy...
June 11, 2018: Hypertension
https://www.readbyqxmd.com/read/29889834/pathological-presentation-of-cardiac-mitochondria-in-a-rat-model-for-chronic-kidney-disease
#18
Einat Bigelman, Lena Cohen, Genya Aharon-Hananel, Ran Levy, Zach Rozenbaum, Ann Saada, Gad Keren, Michal Entin-Meer
BACKGROUND: Mitochondria hold crucial importance in organs with high energy demand especially the heart. We investigated whether chronic kidney disease (CKD), which eventually culminates in cardiorenal syndrome, could affect cardiac mitochondria and assessed the potential involvement of angiotensin II (AngII) in the process. METHODS: Male Lewis rats underwent 5/6 nephrectomy allowing CKD development for eight months or for eleven weeks. Short-term CKD rats were administered with AngII receptor blocker (ARB)...
2018: PloS One
https://www.readbyqxmd.com/read/29887448/pten-induced-putative-kinase-1-pink1-alleviates-angiotensin-ii-induced-cardiac-injury-by-ameliorating-mitochondrial-dysfunction
#19
Wenjun Xiong, Jinghai Hua, Zuheng Liu, Wanqiang Cai, Yujia Bai, Qiong Zhan, Wenyan Lai, Qingchun Zeng, Hao Ren, Dingli Xu
BACKGROUND: Mitochondrial quality control is crucial to the development of angiotensin II (AngII)-induced cardiac hypertrophy. PTEN induced putative kinase 1 (PINK1) is rapidly degraded in normal mitochondria but accumulates in damaged mitochondria, triggering autophagy to protect cells. PINK1 mediates mitophagy in general, but whether PINK1 mediates AngII-induced mitophagy and the effects of PINK1 on AngII-induced injury are unknown. This study was designed to investigate the function of PINK1 in an AngII stimulation model and its regulation of AngII-induced mitophagy...
September 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29886624/-establishment-and-evaluation-of-a-new-method-for-determining-hemodynamics-of-pulmonary-hypertension-rats
#20
Q Y Zheng, M D Kuang, Y Li, X T Wu, J Y Huang, C T Zhang, H W Liu, W J Lu, J Wang, Y Q Chen
Objective: By evaluating the hemodynamic parameters such as cardiac output (CO), right ventricular pressure (RVP), pulmonary artery pressure (PAP) and total pulmonary resistance index (TPRI) in pulmonary hypertension rat model, we established a more comprehensive hemodynamic evaluation system, which objectively evaluated the severity of disease and exercise tolerance in rats with pulmonary hypertension. Methods: SD rats were randomly divided into a control group and a model group with 5 rats in each group. The model group was intraperitoneally injected with SU5416 (20 mg/kg) and placed in an oxygen chamber at a 10% oxygen concentration for 21 days and then placed in a normoxic environment for 14 days...
June 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
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