keyword
MENU ▼
Read by QxMD icon Read
search

lipid trials

keyword
https://www.readbyqxmd.com/read/28646813/hepatoprotective-activity-of-satwa-an-ayurvedic-formulation-against-alcohol-induced-liver-injury-in-rats
#1
Tejaswi Chavan, Abhijit Ghadge, Manjiri Karandikar, Vijaya Pandit, Prabhakar Ranjekar, Omkar Kulkarni, Aniket Kuvalekar, Nitin Mantri
Context • Guduchi Satwa is an Ayurvedic formulation prepared from Tinospora species. It has been used since ancient times to treat liver disorders. Objectives • The study intended to assess the hepatoprotective potential of Satwa prepared from 3 forms of Tinospora against alcohol-induced hepatotoxicity. Design • Male, albino Wistar rats were divided into 6 groups, with 6 rats each: 3 control groups-healthy controls, negative controls, and positive controls-and 3 intervention groups-Tinospora cordifolia, Tinospora sinensis, and Neem-Guduchi...
July 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28646806/potential-of-probiotics-in-hypercholesterolemia-a-review-of-in-vitro-and-in-vivo-findings
#2
Smriti Sharma, Seema Puri, Anura V Kurpad
Context • Coronary heart disease (CHD) is a major public health problem in developing and developed countries. Elevated cholesterol levels, especially low-density lipoprotein (LDL) cholesterol, and the emergence of CHD, have been positively correlated in many clinical and epidemiological studies. The health benefits of probiotics have received a great deal of attention, including their blood cholesterol-lowering effects on humans. Objective • The research team intended to determine the current state of research examining the effects of various probiotic strains on lipid profiles, including measures in serum of total cholesterol, LDL cholesterol, triglycerides, and high-density lipoprotein (HDL) cholesterol...
June 23, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28646377/efficacy-of-an-education-course-delivered-to-community-health-workers-in-diabetes-control-a-randomized-clinical-trial
#3
Camila Furtado de Souza, Mériane Boeira Dalzochio, Alessandra Teixeira Netto Zucatti, Rosana De Nale, Marília Tavares de Almeida, Jorge Luiz Gross, Cristiane Bauermann Leitão
BACKGROUND: Community health workers are community members who provide education and care for patients for a broad range of health issues, including diabetes mellitus. However, few community health workers are trained for diabetes education and little is known about the effectiveness of their interventions. The aim of this study is to evaluate the effect of a diabetes education program delivered to community health workers in improving the metabolic control of patients with type 2 diabetes mellitus...
June 23, 2017: Endocrine
https://www.readbyqxmd.com/read/28645949/double-blind-randomised-controlled-trial-of-the-independent-and-synergistic-effect-of-spirulina-maxima-with-exercise-isese-on-general-fitness-lipid-profile-and-redox-status-in-overweight-and-obese-subjects-study-protocol
#4
Marco Antonio Hernández-Lepe, José Alberto López-Díaz, Laura Alejandra de la Rosa, Rosa Patricia Hernández-Torres, Abraham Wall-Medrano, Marco Antonio Juarez-Oropeza, José Pedraza-Chaverri, Rene Urquidez-Romero, Arnulfo Ramos-Jiménez
INTRODUCTION: In order to reduce cardiovascular disease risk factors, a healthy diet must include dietary antioxidants from different sources (eg, Spirulina maxima) and regular practice of exercise should be promoted. There is some evidence from animal studies that S. maxima and exercise decrease cardiovascular disease risks factors. However, very few studies have proved the independent or synergistic effect of S. maxima plus exercise in humans. This study attempts to address the independent and synergistic effects in overweight and obese subjects participating in a systematic physical exercise programme at moderate intensity on general fitness, plasma lipid profile and antioxidant capacity...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645636/theobromine-does-not-affect-postprandial-lipid-metabolism-and-duodenal-gene-expression-but-has-unfavorable-effects-on-postprandial-glucose-and-insulin-responses-in-humans
#5
Lotte Smolders, Ronald P Mensink, Mark V Boekschoten, Rogier J J de Ridder, Jogchum Plat
BACKGROUND & AIMS: Chocolate consumption is associated with a decreased risk for CVD. Theobromine, a compound in cocoa, may explain these effects as it favorably affected fasting serum lipids. However, long-term effects of theobromine on postprandial metabolism as well as underlying mechanisms have never been studied. The objective was to evaluate the effects of 4-week theobromine consumption (500 mg/day) on fasting and postprandial lipid, lipoprotein and glucose metabolism, and duodenal gene expression...
June 10, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28644688/intraosseous-administration-of-antidotes-a-systematic-review
#6
Audrée Elliott, Pierre-André Dubé, Amélie Cossette-Côté, Laura Patakfalvi, Eric Villeneuve, Martin Morris, Sophie Gosselin
CONTEXT: Intraosseous (IO) access is an established route of administration in resuscitation situations. Patients with serious poisoning presenting to the emergency department may require urgent antidote therapy. However, intravenous (IV) access is not always readily available. OBJECTIVE: This study reviews the current evidence for IO administration of antidotes that could be used in poisoning. The primary outcome was mortality as a surrogate of efficacy. Secondary outcomes included hemodynamic variables, electrocardiographic variables, neurological status, pharmacokinetics outcomes, and adverse effects as defined by each article...
June 23, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28643240/pcsk9-inhibitors-treating-the-right-patients-in-daily-practice
#7
REVIEW
Peta King, Stephen J Nicholls
PURPOSE OF REVIEW: Monoclonal antibodies that inhibit proprotein convertase subtilisin/kexin type 9 (PCSK9) have emerged as a novel approach to low-density lipoprotein cholesterol (LDL-C) lowering. The potential role of PCSK9 inhibitors in clinical practice will be reviewed. RECENT FINDINGS: Clinical trials have demonstrated that PCSK9 inhibitors produce robust LDL-C lowering when administered either as monotherapy or in combination with statins. This provides the opportunity to achieve effective lipid lowering in familial hypercholesterolemia, patients with either established atherosclerotic cardiovascular disease or high risk primary prevention and an important opportunity to treat patients with statin intolerance...
August 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28641384/acute-testosterone-deficiency-alters-adipose-tissue-fatty-acid-storage
#8
Sylvia Santosa, Nikki C Bush, Michael D Jensen
Context: Although the long-term effects of testosterone on adipose tissue lipid metabolism in men have been defined, the short-term regulation of these effects is not well understood. Objective: We examined the effects of acute testosterone withdrawal on subcutaneous abdominal and femoral adipose tissue fatty acid (FA) storage and cellular mechanisms. Design: This was a prospective, randomized trial. Setting: Mayo Clinic Clinical Research Unit...
June 21, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28641031/treatment-options-for-nonalcoholic-steatohepatitis-a-safety-evaluation
#9
Danny Issa, Julia Wattacheril, Arun J Sanyal
Introduction There is an urgent as yet unmet need to develop highly effective and safe therapeutics for nonalcoholic fatty liver disease (NAFLD). The remarkable progress in understanding NAFLD pathogenesis allowed the identification of injury pathways which may be recruited as therapy targets. Areas covered This article reviews the safety and tolerability data of the NAFLD therapies and explains the mechanistic basis for each of the established and investigational drugs. Treatment targets include: weight loss, anti-metabolic agents such as lipid lowering and anti-diabetic drugs, inflammation, fibrosis and others such as targeting gut microbiota, immune modulation and apoptosis...
June 22, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28640164/associations-between-postmenopausal-endogenous-sex-hormones-and-c-reactive-protein-a-clearer-picture-with-regional-adiposity-adjustment
#10
Shannon M Conroy, Heather K Neilson, Rachel O'Reilly, Christy G Woolcott, Frank Z Stanczyk, Kerry S Courneya, Christine M Friedenreich
OBJECTIVE: To better understand the pathogenesis of inflammatory-related diseases after menopause, we studied the adiposity-independent association between endogenous sex hormones and C-reactive protein (CRP), a biomarker of inflammation. METHODS: We conducted a secondary, cross-sectional analysis of baseline data from the Alberta Physical Activity and Breast Cancer Prevention Trial (2003-2007), including 319 healthy, postmenopausal women not using hormone therapy...
June 19, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28639973/sugar-sweetened-beverages-and-cardiometabolic-health
#11
Vasanti S Malik
PURPOSE OF REVIEW: It is widely accepted that sugar sweetened beverages (SSB) are implicated in weight gain and adverse cardiometabolic heath. To make informed recommendations about SSB, new evidence needs to be considered against existing literature. The present review will provide an update on the epidemiological and trial evidence linking intake of SSB to cardiometabolic outcomes. RECENT FINDINGS: The weight of the evidence from prospective cohort studies supports a strong positive association between intake of SSB and weight gain and risk type 2 diabetes (T2D) and coronary heart disease (CHD) that is independent of adiposity...
July 20, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28639694/rancidity-development-of-refrigerated-rainbow-trout-oncorhynchus-mykiss-fillets-comparative-effects-of-in-vivo-and-in-vitro-effects-of-lycopene
#12
Ali Ehsani, Mohammad Sedigh Jasour, Naser Agh, Mohammad Hashemi, Mahdi Khodadadi
BACKGROUND: The problem of lipid oxidation in fish during storage is well known and it is related to both temperature and storage time. Antioxidants could have a main role in limiting deteriorative effects of lipid oxidation in fish. The present study was conducted to investigate the effect of dietary supplement against postmortem addition of lycopene on deterioration of trout fillets during storage at 4±1°C for 12 days. RESULTS: At the end of feeding trial, no significant differences were observed among fatty acid composition of different dietary groups...
June 22, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28639080/the-use-of-statins-and-risk-of-community-acquired-pneumonia
#13
REVIEW
Mohammed A Batais, Abdur Rahman Khan, Aref A Bin Abdulhak
PURPOSE OF THE REVIEW: Community-acquired pneumonia (CAP) is still associated with a large burden and causes significant morbidity and mortality. Besides universal vaccination and antibiotic treatment, statins as adjunctive therapy may also have a beneficial role in the prevention and treatment of CAP. Our goal from this review is to discuss the epidemiology of CAP, and role of statins as adjunctive therapy in the development of CAP. RECENT FINDINGS: Statins are lipid-lowering medications characterized by their ability to control hypercholesterolemia in addition to other pleiotropic effects that could explain their role in the pathogenesis of CAP...
June 21, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28638812/how-canola-and-sunflower-oils-affect-lipid-profile-and-anthropometric-parameters-of-participants-with-dyslipidemia
#14
Sedigheh Saedi, Mona Noroozi, Naghmeh Khosrotabar, Shadi Mazandarani, Behshid Ghadrdoost
Background: Restricted intakes of saturated and trans-fatty acids and replacement with poly or monounsaturated fatty acids are emphasized in healthy diets. This study evaluates the effects of a six-month consumption of canola oil compared to sunflower oil on lipid profile and anthropometric parameters of people affected by dyslipidemia. Methods: This randomized controlled trial was conducted on 96 patients with dyslipidemia, who were randomly assigned into canola oil or the sunflower oil groups. The participants were instructed to record the contents of their daily meals, beverages, fruits, and snacks a day before treatment, at the second clinic visit, in the third month, and at the end of study (i...
2017: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/28638702/cerebral-blood-flow-evaluation-of-intensive-rosuvastatin-therapy-in-stroke-transient-ischemic-attack-patients-with-intracranial-arterial-atherosclerotic-stenosis-study-rationale%C3%A2-and-design
#15
Xuting Zhang, Ying Zhou, Sheng Zhang, Wenhong Ding, Min Lou
INTRODUCTION: The risk of recurrent stroke is high in patients with intracranial atherosclerotic stenosis (ICAS). Statin use has been demonstrated to decrease the incidence of stroke by reducing atherosclerotic plaque burden. However, its effect on the hemodynamic situation and cerebral perfusion status has not yet been validated. With the use of computed tomography perfusion (CTP), we aim to evaluate the impact of Rosuvastatin on cerebral hemodynamic changes, as well as the downstream perfusion...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28638006/effect-of-probiotics-on-glucose-and-lipid-metabolism-in-type-2-diabetes-mellitus-a-meta-analysis-of-12-randomized-controlled-trials
#16
Kecheng Yao, Linghai Zeng, Qian He, Wei Wang, Jiao Lei, Xiulan Zou
BACKGROUND It has been unclear whether supplemental probiotics therapy improves clinical outcomes in type 2 diabetic patients. This meta-analysis aimed to summarize the effect of probiotics on glucose and lipid metabolism and C-reactive protein (CRP) from 12 randomized controlled trials (RCTs). MATERIAL AND METHODS An up-to-date search was performed for all relevant RCTs up to April 2016 from PubMed, Embase, and Cochrane Library. Standardized mean difference (SMD) and weighted mean difference (WMD) were calculated for a fixed-effect and random-effect meta-analysis to assess the impact of supplemental probiotics on fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipid profile, and CRP level...
June 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28637494/euiiyin-tang-in-the-treatment-of-obesity-study-protocol-for-a-randomised-controlled-trial
#17
Chunhoo Cheon, Soobin Jang, Jeong-Su Park, Youme Ko, Doh Sun Kim, Byung Hoon Lee, Hyun Jong Song, Yun-Kyung Song, Bo-Hyoung Jang, Yong-Cheol Shin, Seong-Gyu Ko
BACKGROUND: Obesity is a public health concern in many countries due to its increasing prevalence. Euiiyin-tang is an herbal medicine formula often used as a clinical treatment for obesity. It acts to eliminate humidity and purify the blood, the causes of obesity identified by the theoretical framework of Korean medicine. The purpose of this study is to evaluate the efficacy and safety of Euiiyin-tang in treating obesity. METHODS/DESIGN: This study is a randomised, double-blinded and placebo-controlled, multicentre trial...
June 21, 2017: Trials
https://www.readbyqxmd.com/read/28636230/quantification-of-fatty-acids-in-erythrocytes-and-plasma-by-fast-gas-chromatography
#18
Cristina Cruz-Hernandez, Sagar K Thakkar, Isabelle Masserey-Elmelegy, William Bousi, Patric Fontannaz, Francesca Giuffrida
As a result of the heterogeneous nature of lipid classes in complex biological matrices such as plasma and erythrocytes, it is imperative to have a robust and validated methodology for fatty acid quantification. The effective method presented here combines available methodology of fast gas chromatography and an improvement of the sample preparation methodology before injection into the gas chromatograph. This methodology ensures complete transesterification and quantification of total and individual fatty acids (and not only in relative amounts) by addition of internal standards...
June 21, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28636182/effects-of-green-tea-on-lipid-metabolism-in-overweight-or-obese-people-a-meta-analysis-of-randomized-controlled-trials
#19
Yuan Fen, Dong Hui, Fang Ke, Gong Jing, Lu Fu Er
SCOPE: The effects of green tea on lipid metabolism were inconsistent. The objective of this meta-analysis was to evaluate the effects of green tea on lipid metabolism in overweight or obese people. METHODS AND RESULTS: We searched randomized controlled trials(RCTs) comparing green tea with a control on lipid metabolism on PUBMED and WEB OF SCIENCE (January 1990 to September 2016), COCHRANE and EMBASE (updated to October 2016), and the Chinese databases CNKI, WanFang and CBMD...
June 21, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28634491/more-favorable-metabolic-impact-of-three-times-weekly-versus-daily-growth-hormone-treatment-in-na%C3%A3-ve-gh-deficient-children
#20
Alessandro Ciresi, Floriana Cicciò, Stefano Radellini, Valentina Guarnotta, Anna Maria Calcaterra, Carla Giordano
OBJECTIVE: To evaluate whether two different regimens of weekly injections could lead to similar auxological and metabolic effects in children with growth hormone deficiency (GHD). DESIGN: 32 GHD children (25 males, mean age 10.5 ± 2.2 yr) were randomly assigned to receive daily (group A, 16 patients) or TIW (group B, 16 patients) GHT for 12 months. METHODS: Auxological parameters, insulin-like growth factor-I (IGF-I), glucose and insulin during OGTT, glycosylated hemoglobin (HbA1c), lipid profile, the oral disposition index (DIo), the homeostasis model assessment estimate of insulin resistance (Homa-IR), and the insulin sensitivity index (ISI)...
2017: International Journal of Endocrinology
keyword
keyword
92109
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"