keyword
MENU ▼
Read by QxMD icon Read
search

lipid trials

keyword
https://www.readbyqxmd.com/read/29917038/serum-untargeted-metabolomic-profile-of-the-dietary-approaches-to-stop-hypertension-dash-dietary-pattern
#1
Casey M Rebholz, Alice H Lichtenstein, Zihe Zheng, Lawrence J Appel, Josef Coresh
Background: The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is recommended for cardiovascular disease risk reduction. Assessment of dietary intake has been limited to subjective measures and a few biomarkers from 24-h urine collections. Objective: The aim of the study was to use metabolomics to identify serum compounds that are associated with adherence to the DASH dietary pattern. Design: We conducted untargeted metabolomic profiling in serum specimens collected at the end of 8 wk following the DASH diet (n = 110), the fruit and vegetables diet (n = 111), or a control diet (n = 108) in a multicenter, randomized clinical feeding study (n = 329)...
June 18, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29915897/darunavir-cobicistat-emtricitabine-tenofovir-alafenamide-a-review-in-hiv-1-infection
#2
Emma D Deeks
Darunavir/cobicistat/emtricitabine/tenofovir AF (Symtuza® ) is the first protease inhibitor (PI)-based single-tablet regimen (STR) available for the treatment of adults and adolescents (aged ≥ 12 years) with HIV-1 infection. It combines the PI darunavir (which has a high genetic barrier to resistance) with the pharmacokinetic booster cobicistat and the nucleos(t)ide reverse transcriptase inhibitors emtricitabine and tenofovir alafenamide (tenofovir AF), the latter being associated with less off-target tenofovir exposure than its predecessor tenofovir disoproxil fumarate (tenofovir DF)...
June 18, 2018: Drugs
https://www.readbyqxmd.com/read/29914662/meta-analysis-indicates-that-resistant-starch-lowers-serum-total-cholesterol-and-low-density-cholesterol
#3
REVIEW
H C Yuan, Y Meng, H Bai, D Q Shen, B C Wan, L Y Chen
The effects of resistant starch (RS) on serum cholesterol levels have been previously investigated. However, the results of those studies are inconsistent. The purpose of our meta-analysis was to determine if RS affects blood lipids based on the current literature. The methods included searching databases (PubMed, Embase, Scopus, and Cochrane Library) up to September 2017, as well as hand-searching reference lists of articles published in English. The initial search yielded 1228 articles. Of these, 14 articles (20 trials) were included in our investigation focusing on the effects of RS on total cholesterol (TC; 19 trials), triglycerides (TG; 19 trials), low-density lipoprotein cholesterol (LDL-C; 16 trials), and high-density lipoprotein cholesterol (17 trials)...
June 2018: Nutrition Research
https://www.readbyqxmd.com/read/29914534/efficacy-of-low-protein-diet-for-diabetic-nephropathy-a-systematic-review-of-randomized-controlled-trials
#4
Huan-Gao Zhu, Zhao-Shun Jiang, Pi-Yun Gong, Dong-Mei Zhang, Zhi-Wei Zou, Qian-Zhang, Hui-Mei Ma, Zhen-Gang Guo, Jun-Yu Zhao, Jian-Jun Dong, Lin-Liao
BACKGROUND: A low-protein diet (LPD) is believed to be beneficial in slowing the progression of kidney disease. It is reported that low protein diet can improve protein, sugar and lipid metabolism, and reduce the symptoms and complications of renal insufficiency. However, there has been controversial regarding the effects of protein restriction on diabetic nephropathy (DN). OBJECTIVE: To investigate the efficacy of LPD on renal function in patients with type 1 or 2 DN by meta-analysis of randomized controlled trials (RCTs)...
June 19, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29914039/does-treating-vascular-risk-factors-prevent-dementia-and-alzheimer-s-disease-a-systematic-review-and-meta-analysis
#5
Susanna C Larsson, Hugh S Markus
BACKGROUND: Epidemiological evidence has associated Alzheimer's disease (AD) with vascular risk factors (VRFs), but whether treatment of VRFs reduces the incidence of dementia and AD is uncertain. OBJECTIVE: To conduct a systematic review and meta-analysis to summarize available data on the impact of treatment of VRFs on dementia and AD incidence. METHODS: Pertinent studies published until 1 January 2018 were identified from PubMed. Both randomized controlled trials (RCT) and prospective studies that investigated the impact of treatment of VRFs on dementia or AD incidence were included...
June 9, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29912604/investigation-of-the-effect-of-dietary-docosahexaenoic-acid-dha-supplementation-on-macular-function-in-subjects-with-autosomal-recessive-stargardt-macular-dystrophy
#6
Ian M MacDonald, Paul A Sieving
PURPOSE: To test the effect of docosahexanoic acid (DHA) dietary supplementation on macular function in patients with Stargardt disease. MATERIALS AND METHODS: A single center, double-masked, randomized placebo-controlled trial of 11 subjects (2 males, 9 females) with Stargardt disease in a crossover design (NCT00060749). Six participants were randomized to two sequences of three month periods of DHA supplementation (2000 mg/day) followed by three months of placebo...
June 18, 2018: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29912570/the-use-of-a-stem-and-leaf-aqueous-extract-of-cissus-quadrangularis-cqr-300-to-reduce-body-fat-and-other-components-of-metabolic-syndrome-in-overweight-participants
#7
Robert Nash, Boris Azantsa, Dieudonne Kuate, Harrinder Singh, Julius Oben
BACKGROUND: Previous work had shown the ability of an aqueous leaf and stem extract of Cissus quandrangularis (300 mg of CQR, CQR-300) to improve components of metabolic syndrome (MS) in overweight individuals. OBJECTIVE: This small pilot study aimed to confirm the efficacy of CQR-300 in reducing the percentage body fat measured using two different methods-bioelectrical impedance assay versus dual-energy X-ray absorptiometry (DEXA). DESIGN: The study was an 8-week double-blind, placebo-controlled pilot trial on 67 individuals who were requested by a dietary counselor to maintain their normal exercise and dietary routines...
June 18, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29912318/bayesian-inference-for-network-meta-regression-using-multivariate-random-effects-with-applications-to-cholesterol-lowering-drugs
#8
Hao Li, Ming-Hui Chen, Joseph G Ibrahim, Sungduk Kim, Arvind K Shah, Jianxin Lin, Andrew M Tershakovec
Low-density lipoprotein cholesterol (LDL-C) has been identified as a causative factor for atherosclerosis and related coronary heart disease, and as the main target for cholesterol- and lipid-lowering therapy. Statin drugs inhibit cholesterol synthesis in the liver and are typically the first line of therapy to lower elevated levels of LDL-C. On the other hand, a different drug, Ezetimibe, inhibits the absorption of cholesterol by the small intestine and provides a different mechanism of action. Many clinical trials have been carried out on safety and efficacy evaluation of cholesterol lowering drugs...
April 18, 2018: Biostatistics
https://www.readbyqxmd.com/read/29912307/immediate-vs-deferred-switching-from-a-boosted-protease-inhibitor-pi-r-based-regimen-to-a-dolutegravir-dtg-based-regimen-in-virologically-suppressed-patients-with-high-cardiovascular-risk-or-age-%C3%A2-50-years-final-96-weeks-results-of-neat-022-study
#9
José M Gatell, Lambert Assoumou, Graeme Moyle, Laura Waters, Margaret Johnson, Pere Domingo, Julie Fox, Esteban Martinez, Hans-Jürgen Stellbrink, Giovanni Guaraldi, Mar Masia, Mark Gompels, Stephane De Wit, Eric Florence, Stefan Esser, François Raffi, Christoph Stephan, Juergen Rockstroh, Andrea Giacomelli, Jaime Vera, José Ignacio Bernardino, Alan Winston, Maria Saumoy, Julien Gras, Christine Katlama, Anton L Pozniak
Background: Both immediate or deferred switching from a PI/r to DTG may improve lipid profile. Methods: NEAT022 is a European, open label, randomized, trial. HIV-infected adults ≥ 50 years or with a Framingham score ≥10% were eligible if HIV RNA < 50 copies/mL. Patients were randomized to switch the PI/r to DTG immediately (DTG-I) or to deferred switch at week 48 (DTG-D) . Week 96 end-points were: proportion of patients with HIV RNA < 50 copies/ml, percentage change of lipid fractions and adverse events...
June 14, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29909352/the-role-of-milk-fat-globule-membranes-in-behavior-and-cognitive-function-using-a-suckling-rat-pup-supplementation-model
#10
Lauren R Brink, Bo Lönnerdal
Milk fat globule membranes (MFGM) surround droplets delivering lipids to the breast-fed infant and are enriched with glycoproteins upon exocytosis out of the mammary cell. MFGM is typically removed during processing of cow milk for the manufacture of infant formula. Recent clinical trials have found that formula supplemented with bovine MFGM improved cognition. Here, we aimed to explore the mechanisms behind this improved developmental outcome. Sprague-Dawley rats were bred, and their litters were manipulated to either 10 pups to represent normal growth (N) or 16 pups to represent restricted growth (R) per dam...
May 21, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29909238/autophagy-as-an-emerging-target-in-cardiorenal-metabolic-disease-from-pathophysiology-to-management
#11
REVIEW
Yingmei Zhang, Adam T Whaley-Connell, James R Sowers, Jun Ren
Although advances in medical technology and health care have improved the early diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity, insulin resistance, diabetes, hypertension, dyslipidemia, and kidney disease remains high. Findings from numerous population-based studies, clinical trials, and experimental evidence have consolidated a number of theories for the pathogenesis of cardiorenal metabolic anomalies including resistance to the metabolic action of insulin, abnormal glucose and lipid metabolism, oxidative and nitrosative stress, endoplasmic reticulum (ER) stress, apoptosis, mitochondrial damage, and inflammation...
June 15, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29908688/the-effect-of-honey-consumption-compared-with-sucrose-on-lipid-profile-in-young-healthy-subjects-randomized-clinical-trial
#12
Hamid Rasad, Mohammad Hassan Entezari, Ehsan Ghadiri, Behzad Mahaki, Naseh Pahlavani
BACKGROUND AND AIMS: Several studies have demonstrated that honey consumption has beneficial effects on cardiovascular disease indicators. The current study aimed to investigate the effect of honey consumption compared with sucrose on lipid profile among young healthy subjects. METHODS: Sixty healthy subjects, aged 18-30 years, were randomly recruited into this double blind randomized trial and assigned into two groups: honey (received 70 g honey per day) and sucrose (received 70 g sucrose per day) groups...
August 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29908675/cocoa-ingestion-protects-plasma-lipids-in-healthy-males-against-ex-vivo-oxidative-conditions-a-randomized-clinical-trial
#13
Manuel Barrios, Luis C Orozco, Elena E Stashenko
The effects of in vivo cocoa-based supplementation were studied as a preconditioning treatment for ex vivo acute oxidative conditions in a controlled randomized clinical trial. Subjects were 100 healthy young men at Universidad Industrial de Santander blinded to the intervention and divided into two groups: The intervention group (n = 50) receiving 30 g of cocoa powder and 50 g of dark chocolate/d for 1 week with the remaining subjects receiving placebo. Cocoa products preconditioning for 1 week resulted in modifications in the susceptibility of plasma lipids over ex vivo oxidative conditions with effects of i) a significant increase in the oxidative resistance of plasma lipids measured by dienes formation (4...
August 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29908345/functional-and-physiological-adaptations-following-concurrent-training-using-sets-with-and-without-concentric-failure-in-elderly-men-a-randomized-clinical-trial
#14
Eduardo Lusa Cadore, Erik Menger, Juliana Lopes Teodoro, Larissa Xavier Neves da Silva, Francesco Pinto Boeno, Daniel Umpierre, Cíntia Ehlers Botton, Rodrigo Ferrari, Giovani Dos Santos Cunha, Mikel Izquierdo, Ronei Silveira Pinto
This study compared the functional and physiological adaptations induced by concurrent training (CT) performed with repetitions to concentric failure and not to failure in elderly men. Fifty-two individuals (66.2 ± 5.2 years) completed the pre- and post-measurements and were divided into three groups: repetitions to failure (RFG, n = 17); repetitions not to failure (NFG, n = 20); and repetitions not to failure with total volume equalized to that in the RFG (ENFG, n = 15). The participants' sit-to-stand ability, timed-up-and-go (TUG), muscle power output in squat jump (SJ) and countermovement jump (CMJ), peak oxygen uptake (VO2peak ), blood lipids and glucose, as well as blood pressure levels were assessed...
June 13, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29908257/rutin-attenuates-neurobehavioral-deficits-oxidative-stress-neuro-inflammation-and-apoptosis-in-fluoride-treated-rats
#15
Kpobari W Nkpaa, Godspower I Onyeso
Studies have shown that high exposure to fluoride (NaF) induces neurotoxicity. Rutin (RUT), a citrus flavonoid, has been reported to have antioxidant, anti-inflammatory and anti-apoptotic properties. The aim of this study was to investigate the neuroprotective mechanism(s) of RUT on NaF - induced neurotoxicity. Rats were exposed to NaF alone in drinking water at 15 mg/L alone ad libitum or orally co-treated by gavage with RUT at 50 and 100 mg/kg body weight for 31 consecutive days. A video-tracking software was used to monitor the motor and locomotive behavior during a 5 - min trial time in a novel environment...
June 13, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29904807/determinants-of-achieved-ldl-cholesterol-and-non-hdl-cholesterol-in-the-management-of-dyslipidemias
#16
REVIEW
Chris J Packard
PURPOSE OF REVIEW: The advent of combination therapy to provide LDL lowering beyond that achieved with statins necessitates the development of greater understanding of how drugs work together, what changes occur in key lipoprotein fractions, and what residual risk remains. RECENT FINDINGS: Clinical trials of agents that, when added to statins, generate profound LDL lowering have been successful in reducing further the risk of cardiovascular disease. LDL cholesterol can be now decreased to unprecedented levels, so the focus of attention then shifts to other apolipoprotein B-containing, atherogenic lipoprotein classes such as lipoprotein(a) and remnants of the metabolism of triglyceride-rich particles...
June 14, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29904777/science-behind-the-cardio-metabolic-benefits-of-omega-3-polyunsaturated-fatty-acids-biochemical-effects-vs-clinical-outcomes
#17
REVIEW
Rohith N Thota, Jessica J A Ferguson, Kylie A Abbott, Cintia B Dias, Manohar L Garg
Lower incidence of cardiovascular disease (CVD) in the Greenland Inuit, Northern Canada and Japan has been attributed to their consumption of seafood rich in long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA). While a large majority of pre-clinical and intervention trials have demonstrated heart health benefits of LCn-3PUFA, some studies have shown no effects or even negative effects. LCn-3PUFA have been shown to favourably modulate blood lipid levels, particularly a reduction in circulating levels of triglycerides...
June 15, 2018: Food & Function
https://www.readbyqxmd.com/read/29903781/how-good-are-gps-at-adhering-to-a-pragmatic-trial-protocol-in-primary-care-results-from-the-addition-cambridge-cluster-randomised-pragmatic-trial
#18
Michael Laxy, Edward C F Wilson, Clare E Boothby, Simon J Griffin
OBJECTIVE: To assess the fidelity of general practitioners' (GPs) adherence to a long-term pragmatic trial protocol. DESIGN: Retrospective analyses of electronic primary care records of participants in the pragmatic cluster-randomised ADDITION (Anglo-Danish-Dutch Study of Intensive Treatment In People with Screen Detected Diabetes in Primary Care)-Cambridge trial, comparing intensive multifactorial treatment (IT) versus routine care (RC). Data were collected from the date of diagnosis until December 2010...
June 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29903591/effect-of-combined-training-on-body-composition-and-metabolic-variables-in-people-living-with-hiv-a-randomized-clinical-trial
#19
Débora Alves Guariglia, Rafael Evangelista Pedro, Rafael Deminice, Flávia Troncon Rosa, Sidney Barnabé Peres, Solange Marta Franzói De Moraes
PURPOSE: The aim of this study was to conduct a randomized clinical trial to assess the effects of 16 weeks of combined training on body composition, lipid profile, adiponectin, C-reactive protein (CRP), and leptin levels in people living with HIV/AIDS (PLWHA). METHODS: Fifty-eight HIV-infected individuals were randomized into a training group (T) or a control group (C). Combined training consisted of aerobic and resistance exercises performed at the same training session, applied at a frequency of three times a week for a total of 16 weeks...
June 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29903515/the-nonalcoholic-fatty-liver-disease-nafld-fibrosis-score-cardiovascular-risk-stratification-and-a-strategy-for-secondary-prevention-with-ezetimibe
#20
Tracey G Simon, Kathleen E Corey, Christopher P Cannon, Michael Blazing, Jeong-Gun Park, Michelle L O'Donoghue, Raymond T Chung, Robert P Giugliano
OBJECTIVE: The nonalcoholic fatty liver disease fibrosis score (NFS) is comprised of unique metabolic risk indicators that may accurately predict residual cardiovascular (CV) risk in patients with established coronary disease and metabolic dysfunction. METHODS: We applied the NFS prospectively to 14,819 post-ACS patients randomized to ezetimibe/simvastatin (E/S) or placebo/simvastatin (P/S), in the IMPROVE-IT trial, using validated NFS cutoffs. The primary endpoint included CV death, myocardial infarction, unstable angina, revascularization or stroke...
May 26, 2018: International Journal of Cardiology
keyword
keyword
92109
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"