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lipid trials

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https://www.readbyqxmd.com/read/29690924/the-effect-of-regularly-dosed-paracetamol-versus-no-paracetamol-on-renal-function-in-plasmodium-knowlesi-malaria-packnow-study-protocol-for-a-randomised-controlled-trial
#1
Daniel J Cooper, Katherine Plewes, Matthew J Grigg, Giri S Rajahram, Kim A Piera, Timothy William, Mark D Chatfield, Tsin Wen Yeo, Arjen M Dondorp, Nicholas M Anstey, Bridget E Barber
BACKGROUND: Plasmodium knowlesi is the most common cause of human malaria in Malaysia. Acute kidney injury (AKI) is a frequent complication. AKI of any cause can have long-term consequences, including increased risk of chronic kidney disease, adverse cardiovascular events and increased mortality. Additional management strategies are therefore needed to reduce the frequency and severity of AKI in malaria. In falciparum malaria, cell-free haemoglobin (CFHb)-mediated oxidative damage contributes to AKI...
April 24, 2018: Trials
https://www.readbyqxmd.com/read/29688308/visit-to-visit-cholesterol-variability-correlates-with-coronary-atheroma-progression-and-clinical-outcomes
#2
Donald Clark, Stephen J Nicholls, Julie St John, Mohamed B Elshazly, Samir R Kapadia, E Murat Tuzcu, Steven E Nissen, Rishi Puri
Aims: Utilizing serial intravascular ultrasonography (IVUS), we aimed to exam the association of intra-individual lipid variability, coronary atheroma progression, and clinical outcomes. Methods and results: We performed a post hoc patient-level analysis of nine clinical trials involving 4976 patients with coronary artery disease who underwent serial coronary IVUS in the setting of a range of medical therapies. We assessed the associations between progression in percent atheroma volume (ΔPAV), clinical outcomes, and visit-to-visit lipid variability including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL-C, total cholesterol (TC)/HDL-C, and apolipoprotein B (ApoB)...
April 21, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29687016/dietary-patterns-and-physical-activity-correlate-with-total-cholesterol-independently-of-lipid-lowering-drugs-and-antiretroviral-therapy-in-aging-people-living-with-human-immunodeficiency-virus
#3
Alex Marzel, Roger D Kouyos, Sara Reinschmidt, Katharina Balzer, Fabienne Garon, Monica Spitaleri, Nicolas Matthes, Paolo Suter, Rainer Weber, Cornelia Staehelin, Thanh Doco Lecompte, Philip Tarr, Helen Kovari
Background: Hypercholesterolemia is a well established risk factor for coronary heart disease and is highly prevalent among human immunodeficiency virus (HIV)-positive persons. Antiretroviral therapy (ART) can both directly modify total cholesterol and have drug-drug interactions with statins. This makes investigating modifiable behavioral predictors of total cholesterol a pertinent task. Methods: To explore the association between diet and physical activity with cross-sectionally measured total cholesterol, we administered a validated Food-Frequency-Questionnaire to participants of the Swiss HIV Cohort Study ≥45 years old...
April 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29685823/the-benefits-of-yoga-practice-compared-to-physical-exercise-in-the-management-of-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#4
REVIEW
Ranil Jayawardena, Priyanga Ranasinghe, Tharindu Chathuranga, Piyusha Milani Atapattu, Anoop Misra
Yoga is increasingly used as an adjunctive therapy in the management of Type-2 Diabetes Mellitus (T2DM). The present study aims to systematically evaluate the literature and perform a meta-analysis on the effects of yoga practice compared to physical exercise in the management of T2DM. Data were obtained using a stepwise search process using keywords in the following online medical databases; PubMed, Web of Science and Scopus. All controlled clinical trials involving patients with T2DM, comparing yoga as an intervention with physical exercise and evaluating glycaemic control and other outcomes between the intervention and control groups were included in the analysis...
April 18, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29685591/cardiovascular-event-reduction-with-pcsk9-inhibition-among-1578-patients-with-familial-hypercholesterolemia-results-from-the-spire-randomized-trials-of-bococizumab
#5
Paul M Ridker, Lynda M Rose, John J P Kastelein, Raul D Santos, Caimiao Wei, James Revkin, Carla Yunis, Jean-Claude Tardif, Charles L Shear
BACKGROUND: Familial hypercholesterolemia (FH) is a dominant genetic disorder associated with elevated low-density lipoprotein cholesterol (LDL-C) and premature atherosclerotic events. Although therapeutic monoclonal antibodies that inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9) are indicated for LDL-C reduction among adult patients with FH, placebo-controlled outcome data among FH patients are scant. OBJECTIVE: Directly compare the efficacy of PCSK9 inhibition as compared to placebo on hard cardiovascular outcomes in FH patients enrolled in the Studies of PCSK9 Inhibition and the Reduction of vascular Events (SPIRE) program...
April 3, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29683854/increased-cholesterol-absorption-rather-than-synthesis-is-involved-in-boosted-protease-inhibitor-associated-hypercholesterolaemia
#6
Pere Leyes, Montserrat Cofan, Ana González-Cordón, Elisa de Lazzari, Joan Trabal, Pere Domingo, Eugenia Negredo, Francesc Vidal, Maria T Forga, Jose M Gatell, Emili Ros, Esteban Martínez
OBJECTIVE: The aim of this study was to compare the differential effects of first-line efavirenz (EFV)-based vs. boosted lopinavir-based antiretroviral regimens on cholesterol metabolism. DESIGN: Multicentre, open-label, randomized clinical trial. METHODS: Forty-nine naïve HIV-infected patients were randomized (1 : 1) to receive either ritonavir-boosted lopinavir (LPV/r) or EFV both in combination with tenofovir and emtricitabine (ClinicalTrials...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29682589/parenterally-administered-norovirus-gii-4-virus-like-particle-vaccine-formulated-with-aluminum-hydroxide-or-monophosphoryl-lipid-a-adjuvants-induces-systemic-but-not-mucosal-immune-responses-in-mice
#7
Suvi Heinimäki, Maria Malm, Timo Vesikari, Vesna Blazevic
Norovirus (NoV) is a main cause of acute gastroenteritis across all ages worldwide. NoV vaccine candidates currently in clinical trials are based on noninfectious highly immunogenic virus-like particles (VLPs) delivered intramuscularly (IM). Since NoV is an enteric pathogen, it is likely that mucosal immunity has a significant role in protection from infection in the intestine. Due to the fact that IM delivery of NoV VLPs does not generate mucosal immunity, we investigated whether NoV genotype GII.4 VLPs coadministered with aluminum hydroxide (Al(OH)3 ) or monophosphoryl lipid A (MPLA) would induce mucosal antibodies in mice...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29681975/mind-body-therapies-for-african-american-women-at-risk-for-cardiometabolic-disease-a-systematic-review
#8
REVIEW
Candace C Johnson, Karen M Sheffield, Roy E Brown
Background: A major determinant in cardiometabolic health is metabolic syndrome (MetS), a cluster of symptoms that portend the development of cardiovascular disease (CVD). As mind-body therapies are thought to help in lowering physiological and environmental CVD risk factors including blood pressure and psychological stress, they may also be beneficial for the primary prevention of CVD. Objectives: To synthesize and summarize existing knowledge on the effectiveness of mind-body therapies on MetS outcomes in African-American (AA) women, a US subpopulation at high risk for CVD...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29680359/effects-of-6-vs-3-eucaloric-meal-patterns-on-glycaemic-control-and-satiety-in-people-with-impaired-glucose-tolerance-or-overt-type-2-diabetes-a-randomized-trial
#9
E Papakonstantinou, M D Kontogianni, P Mitrou, E Magriplis, D Vassiliadi, T Nomikos, V Lambadiari, E Georgousopoulou, G Dimitriadis
BACKGROUND/OBJECTIVES: The study aimed to compare the effects of two eucaloric meal patterns (3 vs 6 meals/day) on glycaemic control and satiety in subjects with impaired glucose tolerance and plasma glucose (PG) levels 140-199mg/dL at 120min (IGT-A) or PG levels 140-199mg/dL at 120min and >200mg/dL at 30/60/90min post-oral glucose load on 75-g OGTT (IGT-B), or overt treatment-naïve type 2 diabetes (T2D). SUBJECTS/METHODS: In this randomized crossover study, subjects with IGT-A (n=15, BMI: 32...
April 6, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29679303/do-the-sglt-2-inhibitors-offer-more-than-hypoglycemic-activity
#10
REVIEW
Eduardo Flores, Carlos G Santos-Gallego, Nely Diaz-Mejía, Juan Jose Badimon
Type 2 diabetes mellitus (T2DM) is one of the most common chronic health conditions in the USA; it affects approximately 10% of adults with up to one-quarter being undiagnosed. T2DM is associated with substantial cardiovascular (CV) morbidity and mortality. T2DM is a pathological condition characterized by elevated levels of glucose and associated with high CV risk. Traditional hypoglycemic drugs have demonstrated their capability for effective and maintained management of high glucose levels, but they have not significantly impacted on the incidence of CV events...
April 20, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29679149/totally-endoscopic-implant-to-effect-a-gastric-bypass-12-month-safety-and-efficacy-outcomes
#11
Bryan J Sandler, Laurent Biertho, Mehran Anvari, Roberto Rumbaut, Luis Alonso Morales-Garza, Gustavo Torres-Barrera, Simon Marceau, Dennis Hong, C Daniel Smith, Santiago Horgan
BACKGROUND: Only a small percentage of candidates for bariatric surgery ever undergo a procedure for weight loss. Devices duplicating key effects of bariatric surgeries with removable, fully trans-oral implants could extend their benefits to patients unwilling to undergo anatomy-altering abdominal surgeries. METHODS: Thirty-two obese subjects (mean BMI: 42.3) were enrolled in a prospective, multicenter, single-arm, feasibility trial of the first fully trans-oral endoscopic gastrointestinal bypass device...
April 20, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29677285/challenges-in-interpreting-the-lipid-lowering-trials-biology-vs-ecology
#12
Ann Marie Navar, Eric D Peterson
No abstract text is available yet for this article.
April 17, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29672965/acute-hematological-and-mood-perception-effects-of-bitter-orange-extract-p-synephrine-consumed-alone-and-in-combination-with-caffeine-a-placebo-controlled-double-blind-study
#13
Jill A Bush, Nicholas A Ratamess, Sidney J Stohs, Nicole L Ellis, Ira T Vought, Elizabeth A O'Grady, Jeremy D Kuper, Jie Kang, Avery D Faigenbaum
The purpose of this study was to examine acute hematological and mood perception responses to supplementation with p-synephrine alone and in combination with caffeine during quiet sitting. Sixteen subjects visited the laboratory on 6 occasions and were given (in randomized double-blind manner) 103-mg p-synephrine (S), 233-mg caffeine + 104-mg p-synephrine, 240-mg caffeine, 337-mg caffeine + 46-mg p-synephrine, 325-mg caffeine, or a placebo (PL). The subjects sat quietly for 3 hr while completing mood state questionnaires every 30 min...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29672196/the-effects-of-synbiotic-supplementation-on-body-mass-index-metabolic-and-inflammatory-biomarkers-and-appetite-in-patients-with-metabolic-syndrome-a-triple-blind-randomized-controlled-trial
#14
Samira Rabiei, Mehdi Hedayati, Bahram Rashidkhani, Navid Saadat, Rahebeh Shakerhossini
It has been shown recently that metabolic syndrome is associated with gut dysbiosis. The gut microbiota may be the main target for prevention or treatment of metabolic syndrome. We investigated the effects of synbiotic supplementation on metabolic syndrome. In this triple-blinded clinical trial, 46 Iranian patients with metabolic syndrome, from both sexes, aged 25-70 years, who fulfilled inclusion criteria were randomly categorized to receive either the synbiotic or a placebo capsule, twice a day for three months, plus a weight-loss diet using stratified random sampling based on body mass index (BMI)...
April 19, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29670837/assessing-the-effect-of-high-performance-inulin-supplementation-via-klf5-mrna-expression-in-adults-with-type-2-diabetes-a-randomized-placebo-controlled-clinical-trail
#15
Abed Ghavami, Neda Roshanravan, Shahriar Alipour, Meisam Barati, Behzad Mansoori, Faezeh Ghalichi, Elyas Nattagh-Eshtivan, Alireza Ostadrahimi
Purpose: The worldwide prevalence of metabolic disorders such as diabetes is increasing rapidly. Currently, the complications of diabetes are the major health concern. The aim of this study was to investigate the effect of high performance (HP) inulin supplementation on glucose homeostasis via KLF5 mRNA expression in adults with type 2 diabetes. Methods: In the present clinical trial conducted for a duration of 6 weeks, 46 volunteers diabetic patients referring to diabetes clinic in Tabriz, Iran, were randomly assigned into intervention (n= 23, consuming 10 gr/d HP inulin) and control groups (n= 23, consuming 10 gr/ d starch)...
March 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29670474/positive-effect-of-fermented-camel-milk-on-liver-enzymes-of-adolescents-with-metabolic-syndrome-a-double-blind-randomized-cross-over-trial
#16
Zahra Fallah, Awat Feizi, Mahin Hashemipour, Roya Kelishadi
Background: Metabolic syndrome (MetS) has several health consequences. Liver enzymes elevation is among them. Aim: This study aimed to assess the effects of fermented Camel milk (FCM), as a functional food and dairy, on some features of MetS in adolescents including liver enzymes status, serum lipids and anthropometric measures. Methods: Overweight/obese adolescents with MetS were randomly assigned to FCM 250 cc per day for 8 weeks, a 4-week washout, and then to diluted Cow's yogurt (DCY) 250 cc per day for 8 weeks, or the reverse sequence...
March 2018: Materia Socio-medica
https://www.readbyqxmd.com/read/29666518/drying-kinetic-of-tucum-fruits-astrocaryum-aculeatum-meyer-physicochemical-and-functional-properties-characterization
#17
Michele Bezerra Silva, Victor Haber Perez, Nádia Rosa Pereira, Thays da Costa Silveira, Nathalia Ribeiro Ferreira da Silva, Cristilane Macharete de Andrade, Romildo Martins Sampaio
The aim of the present study was to assess the drying kinetic of tucum fruits (epicarp and mesocarp) Astrocaryum aculeatum Meyer at three different temperatures (50, 60, and 70 °C). The physicochemical characterization, water activity, moisture content, including β-carotene and vitamin C content in - natura and dried fruits were analyzed. The fruit fractions presented high β-carotene, protein and lipid levels. Fatty acid profile showed oleic acid as the major fatty acid. Different mathematical models were computed to assess the drying process...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29661196/the-women-s-heart-health-programme-a-pilot-trial-of-sex-specific-cardiovascular-management
#18
Ting Ting Low, Siew Pang Chan, Shin Hnin Wai, Zhou Ang, Kyu Kyu, Kim Yee Lee, Anne Ching, Sarah Comer, Naomi Qiu Pin Tan, Elizabeth Grace Hui En Thong, Tracy Nang, Mohan Dutta, Carolyn S P Lam
BACKGROUND: There is increasing knowledge of sex-specific differences in cardiovascular disease and recognition of sex disparities in management. In our study, we investigated whether a cardiovascular programme tailored to the specific needs of women could lead to improved outcomes. METHODS: We randomised 100 female patients to receive cardiology follow-up with the conventional sex-neutral cardiac programme (control), or the sex-tailored Women's Heart Health Programme (intervention)...
April 16, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29659896/does-metformin-treatment-during-pregnancy-modify-future-metabolic-profile-in-women-with-pcos
#19
Maria Othelie Underdal, Solhild Stridsklev, Ingrid Hennum Oppen, Kristin Høgetveit, Marianne Skovsager Andersen, Eszter Vanky
Context: Worldwide, metformin is prescribed in an attempt to improve pregnancy outcome in PCOS. Metformin may also benefit future health by modulating the increased metabolic stress during pregnancy. Objective: To investigate if metformin during pregnancy modified future metabolic health in women with PCOS. Design: Follow-up study of a randomized controlled trial, which compared metformin to placebo in women with PCOS. Mean follow-up period was 8 years (5-11)...
April 5, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29659865/effects-of-a-multi-element-trace-mineral-injection-and-vitamin-e-supplementation-on-performance-carcass-characteristics-and-color-stability-of-strip-steaks-from-feedlot-heifers
#20
B N Harsh, A C Dilger, D D Boler, D W Shike
The objective was to evaluate the interaction of a trace mineral (TM) injection (Multimin 90) and a supranutritional concentration of dietary vitamin E (VITE) on performance, carcass characteristics and color stability of strip steaks from feedlot heifers. Prior to trial initiation, Angus × Simmental cross heifers (N = 48) were managed on a common diet supplemented to meet NRC recommendations (NRC, 2000). Heifers were stratified by BW and allotted to a 2 x 2 factorial arrangement: 1) no supplemental vitamin E and saline injection (CONT+SAL), 2) 1000 IU vitamin E/heifer·d-1 and saline injection (VITE+SAL), 3) no supplemental vitamin E and TM injection (CONT+MM), or 4) vitamin E and TM injection (VITE+MM)...
April 5, 2018: Journal of Animal Science
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