Margot Chouchana, Clément Delage, Ophélia Godin, Jean-Eudes Fontan, Frank Bellivier, Sebastien Gard, Valérie Aubin, Raoul Belzeaux, Caroline Dubertret, Emmanuel Haffen, Marion Leboyer, Emilie Olie, Philippe Courtet, Mircea Polosan, Paul Roux, Ludovic Samalin, Raymund Schwan, Antoine Lefrere, Vanessa Bloch, Bruno Etain
Monitoring of lamotrigine levels is recommended in epilepsy. However, in bipolar disorders (BD), no study has described the therapeutic range in daily practice and factors being associated to it. We used retrospective data of individuals with BD, treated with lamotrigine, and included in the FondaMental Advanced Centers of Expertise for Bipolar Disorders cohort. We extracted clinical and biological data and explored associations between these variables and lamotrigine concentration/dose (C/D) ratio. The database included 675 individuals who received lamotrigine at inclusion, whose main characteristics were female sex (68...
August 2023: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology