keyword
https://read.qxmd.com/read/38465581/factors-associated-with-lamotrigine-concentration-dose-ratio-in-individuals-with-bipolar-disorders
#1
JOURNAL ARTICLE
Margot Chouchana, Clément Delage, Ophélia Godin, Jean-Eudes Fontan, Frank Bellivier, Sebastien Gard, Valérie Aubin, Raoul Belzeaux, Caroline Dubertret, Emmanuel Haffen, Marion Leboyer, Emilie Olie, Philippe Courtet, Mircea Polosan, Paul Roux, Ludovic Samalin, Raymund Schwan, Antoine Lefrere, Vanessa Bloch, Bruno Etain
Monitoring of lamotrigine levels is recommended in epilepsy. However, in bipolar disorders (BD), no study has described the therapeutic range in daily practice and factors being associated to it. We used retrospective data of individuals with BD, treated with lamotrigine, and included in the FondaMental Advanced Centers of Expertise for Bipolar Disorders cohort. We extracted clinical and biological data and explored associations between these variables and lamotrigine concentration/dose (C/D) ratio. The database included 675 individuals who received lamotrigine at inclusion, whose main characteristics were female sex (68...
August 2023: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/37942926/leukopenia-associated-with-lamotrigine-initiation-after-covid-19-vaccine-booster-a-case-report-and-literature-review
#2
JOURNAL ARTICLE
Tsukasa Murata, Katsuaki Uno, Miki Ito, Takahiko Nagamine
Adverse lamotrigine effects are more likely with concomitant use of antiepileptic drugs, rapid dose titration, and multiple drug use, highlighting the importance of measuring its concentration. Here, lamotrigine was administered the day after the third mRNA vaccination to a 20-year-old bipolar woman with these risk factors. Leukopenia occurred on day 12 without rapid concentration increase, but leukocytes gradually recovered after 22 weeks without discontinuation of lamotrigine. The second mRNA vaccination did not induce leukopenia...
November 9, 2023: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/37936783/lamotrigine-associated-toxic-epidermal-necrolysis
#3
Omair Farooq, Akifa Abbas, Muhammad Ahmad, Abu Bakr Manzoor
Toxic Epidermal Necrolysis (TEN) is an uncommon, idiosyncratic, potentially fatal dermatologic emergency affecting skin and mucous membranes. It is characterized clinically by blistering and widespread exfoliation, and pathologically by apoptosis of keratinocytes and epidermal necrosis. Drugs are one of the most common causative agents. The management ranges from nutritional support, care of denuded skin and mucosa to intravenous immunoglobulins (IVIG). The patient being reported developed TEN, secondary to lamotrigine; an anti-epileptic drug also used for bipolar disorder...
2023: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/37775363/lamotrigine-efficacy-safety-and-tolerability-for-women-of-childbearing-age-with-bipolar-i-disorder-meta-analysis-from-four-randomized-placebo-controlled-maintenance-studies
#4
JOURNAL ARTICLE
Eduard Vieta, Sanman Ghorpade, Arunangshu Biswas, Angshuman Sarkar, Abhay Phansalkar, James Cooper
This meta-analysis investigated the efficacy, safety, and tolerability of lamotrigine versus placebo in preventing relapse and recurrence of mood episodes in women of childbearing age with bipolar I disorder. Following up to 16 weeks' open-label lamotrigine treatment, responders were randomized to double-blind treatment, including lamotrigine 100-400 mg/day or placebo, in four trials of up to 76 weeks. Women aged 18-45 years who received ≥ 1 dose of study treatment and had ≥ 1 efficacy assessment in the double-blind phase were pooled for efficacy analysis...
September 27, 2023: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://read.qxmd.com/read/37098202/ketogenic-diet-in-therapy-of-bipolar-affective-disorder-case-report-and-literature-review
#5
REVIEW
Ireneusz Chmiel
Bipolar affective disorder (BPAD) is a chronic mental disorder, characterised by mood swings, alternating between depression and manic or hypomanic episodes. Unfortunately, in some patients pharmacological treatment does not bring satisfactory results, and a certain group of patients shows resistance to treatment. Therefore, other treatment methods are sought after, including a change in diet. The most promising nutrition model is the ketogenic diet. In the presented case study of a male patient, thanks to the introduction of the ketogenic diet, full remission of the disease was achieved, doses of lamotrigine were reduced and quetiapine was completely discontinued...
December 31, 2022: Psychiatria Polska
https://read.qxmd.com/read/37006998/case-report-progressive-skin-rash-and-lymphadenopathy-associated-with-lamotrigine-valproic-acid-combination-in-a-bipolar-adolescent
#6
Yingxu Duan, Fangxinrui Qiu, Jingyuan Zhou, Shiyu Liu, Die Zhao, Changjian Qiu
Background: Lamotrigine may cause severe skin reactions. There is a known interaction between lamotrigine and valproic acid with an increase in lamotrigine levels and lamotrigine toxicity risk. Few cases of severe rash and systemic reactions in bipolar patients using lamotrigine and valproate have been reported. Here, we report a rare case of severe skin rash and lymphadenopathy associated with lamotrigine-valproic acid combination. Case presentation: An 18-year-old female adolescent with bipolar disorder type I was treated with lamotrigine, magnesium valproate, and perospirone for 12 days...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/36873912/chorea-associated-with-lamotrigine-use
#7
REVIEW
Sofia Rael, Negin Badihian, Kelsey M Smith, Elizabeth A Coon
BACKGROUND: Movement disorders, including chorea, have been cited as a side effect of lamotrigine use. However, the association is controversial and clinical characteristics in such cases are unclear. We sought to explore whether chorea may be associated with lamotrigine use. METHODS: We performed a retrospective chart review of all patients diagnosed with chorea who had concurrent use of lamotrigine between 2000-2022. Demographic information and clinical characteristics were analyzed, including medical comorbidities and concurrent medication use...
2023: Tremor and Other Hyperkinetic Movements
https://read.qxmd.com/read/36751986/pharmacological-treatment-of-bipolar-disorder-and-risk-of-diabetes-mellitus-a-nationwide-study-of-30-451-patients
#8
JOURNAL ARTICLE
Christopher Rohde, Ole Köhler-Forsberg, Andrew A Nierenberg, Søren Dinesen Østergaard
OBJECTIVE: While treatment with antipsychotics and antiepileptics have been associated with an increased risk of diabetes mellitus (DM), lithium may have the opposite effect via inhibition of glycogen synthase kinase-3. The aim of this study was to investigate whether treatment of bipolar disorder with lithium, antipsychotics, or antiepileptics is associated with the risk of DM in a real-world clinical setting. METHODS: Using nationwide registers, we identified all patients diagnosed with bipolar disorder in Danish Psychiatric Services from January 1, 1996, to January 1, 2019 (N = 30,451)...
February 8, 2023: Bipolar Disorders
https://read.qxmd.com/read/36342982/a-naturalistic-24-week-open-label-add-on-study-of-vortioxetine-in-bipolar-depression
#9
JOURNAL ARTICLE
Marcin Siwek, Adrian Andrzej Chrobak, Zbigniew Sołtys, Dominika Dudek, Anna Julia Krupa, Janusz Kazimierz Rybakowski
OBJECTIVES: The efficacy of vortioxetine in major depressive disorder has been evaluated in many studies. However, there is a lack of studies assessing vortioxetine in bipolar depression. METHODS: In 60 patients with bipolar depression, vortioxetine 10-20 mg daily was added to current mood stabilizing medication during 24-week, naturalistic, openlabel study. The most frequent mood stabilizers were lamotrigine, quetiapine, olanzapine, and valproates. The therapeutic efficacy was evaluated by the Clinical Global Impression - Improvement (CGI-I) and Clinical Global Impression - Severity (CGI-S) scales...
June 30, 2022: Psychiatria Polska
https://read.qxmd.com/read/36096797/effect-of-age-and-sex-on-prescriptions-for-outpatients-with-bipolar-disorder-in-the-musubi-study-a-cross%C3%A2-sectional-study
#10
JOURNAL ARTICLE
Yasushi Kawamata, Norio Yasui-Furukori, Naoto Adachi, Hitoshi Ueda, Seiji Hongo, Takaharu Azekawa, Yukihisa Kubota, Eiichi Katsumoto, Koji Edagawa, Eiichiro Goto, Kazuhira Miki, Masaki Kato, Atsuo Nakagawa, Toshiaki Kikuchi, Takashi Tsuboi, Reiji Yoshimura, Kazutaka Shimoda, Koichiro Watanabe
BACKGROUND: Childbearing-aged female patients and elderly patients with bipolar disorder need special attention for pharmacological treatments, but current guidelines provide little information on their pharmacological treatment. In particular, the risk/benefit balance of pharmacological treatment for childbearing-aged females with bipolar disorder is a growing concern. Therefore, we aimed to address the effect of age and sex on psychotropic drug prescription for outpatients with bipolar disorder...
September 12, 2022: Annals of General Psychiatry
https://read.qxmd.com/read/35619263/optimization-of-therapy-in-patients-with-epilepsy-and-psychiatric-comorbidities-key-points
#11
JOURNAL ARTICLE
Francesco Pisani, Laura Rosa Pisani, Maria Antonietta Barbieri, Jose de Leon, Edoardo Spina
Psychiatric disorder comorbidity in patients with epilepsy (PWE) is very frequent with a mean percentage prevalence of up to 50% and even higher. Such a high frequency suggests that epilepsy and psychiatric disorders might share common pathological pathways. Various aspects contribute in making the matter very complex from a therapeutic point of view. Some antiseizure medications (ASMs), namely valproic acid, carbamazepine, and lamotrigine, have mood-stabilising effects and are routinely used for the treatment of bipolar disorder in patients who do not have epilepsy...
2023: Current Neuropharmacology
https://read.qxmd.com/read/35465195/lamotrigine-extraction-and-quantification-by-uplc-dad-in-plasma-from-patients-with-bipolar-disorder
#12
JOURNAL ARTICLE
Claudia V Palacios-Magaña, Elba M Romero-Tejeda, Nicté S Fajardo-Robledo, Luis J González-Ortiz, José G González-Mendez, Fermín P Pacheco-Moisés
A sensitive and efficient analytical process for detecting lamotrigine in acidic solution based in ultra-high-performance liquid chromatography-diode array detector (UPLC-DAD) was developed; the stationary phase used was a C8, 150 × 4.6 mm, 2.6  µ m. The mobile phase consisted of acetonitrile/acidified water (0.01% H3 PO4 and 0.005% triethylamine, pH 2.4) (25 : 75 v/v). Limits of detection and quantification were 0.02  µ g/mL and 0.05  µ g/mL, respectively. The working interval for the evaluation of the method ranged from 0...
2022: International Journal of Analytical Chemistry
https://read.qxmd.com/read/35366598/common-effects-of-bipolar-disorder-medications-on-expression-quantitative-trait-loci-genes
#13
JOURNAL ARTICLE
Trang Tt Truong, Chiara C Bortolasci, Srisaiyini Kidnapillai, Briana Spolding, Bruna Panizzutti, Zoe Sj Liu, Brad Watmuff, Jee Hyun Kim, Olivia M Dean, Mark Richardson, Michael Berk, Ken Walder
The molecular mechanism(s) underpinning the clinical efficacy of the current drugs for bipolar disorder (BD) are largely unknown. This study evaluated the transcriptional perturbations potentially playing roles in the therapeutic efficacy of four commonly prescribed psychotropic drugs used to treat BD. NT2-N cells were treated with lamotrigine, lithium, quetiapine, valproate or vehicle control for 24 h. Genome-wide mRNA expression was quantified by RNA-sequencing. Incorporating drug-induced gene expression profiles with BD-associated transcriptional changes from post-mortem brains, we identified potential therapeutic-relevant genes associated with both drug treatments and BD pathophysiology and focused on expression quantitative trait loci (eQTL) genes with genome-wide association with BD...
March 24, 2022: Journal of Psychiatric Research
https://read.qxmd.com/read/35102082/lamotrigine-induced-mania-warning-report-for-the-identification-of-vulnerable-populations-and-expert-clinical-recommendations-for-prescription
#14
JOURNAL ARTICLE
Gerard Anmella, Isabella Pacchiarotti, Diego Hidalgo-Mazzei, Giovanna Fico, Andrea Murru, Maria Sagué-Vilavella, Silvia Amoretti, Norma Verdolini, Joaquim Radua, Eduard Vieta
Lamotrigine (LTG) is an anticonvulsant drug used for the prevention of depressive episodes in bipolar disorder (BD) that might induce manic episodes in some cases. A 38-year-old man, stabilized with asenapine due to a brief psychotic episode, presented depressive symptoms and LTG was titrated up to 200 mg/day in 6 weeks. One week later he was diagnosed with a first manic episode with psychotic symptoms [Young Mania Rating Scale (YMRS = 31)] and type I BD (BD-I). LTG was withdrawn and he was treated with lithium and lurasidone...
January 31, 2022: International Clinical Psychopharmacology
https://read.qxmd.com/read/34646439/efficacy-and-safety-of-lamotrigine-in-the-treatment-of-bipolar-disorder-across-the-lifespan-a-systematic-review
#15
REVIEW
Frank M C Besag, Michael J Vasey, Aditya N Sharma, Ivan C H Lam
BACKGROUND: Bipolar disorder (BD) is a cyclic mood disorder characterised by alternating episodes of mania/hypomania and depression interspersed with euthymic periods. Lamotrigine (LTG) demonstrated some mood improvement in patients treated for epilepsy, leading to clinical studies in patients with BD and its eventual introduction as maintenance therapy for the prevention of depressive relapse in euthymic patients. Most current clinical guidelines include LTG as a recommended treatment option for the maintenance phase in adult BD, consistent with its global licencing status...
2021: Therapeutic Advances in Psychopharmacology
https://read.qxmd.com/read/34423713/udp-glucuronosyltransferase-1a4-mediated-n2-glucuronidation-is-the-major-metabolic-pathway-of-lamotrigine-in-chimeric-nog-tkm30-mice-with-humanised-livers
#16
JOURNAL ARTICLE
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki, Hiroshi Suemizu
Lamotrigine is a phenyltriazine anticonvulsant used to treat epilepsy and bipolar disorder, with species-dependent metabolic profiles. In this study, we investigated the metabolism of lamotrigine in chimeric NOG-TKm30 mice transplanted with human hepatocytes (humanised-liver mice).Substantial lamotrigine N2-glucuronidation activities were observed in the liver microsomes from humanised-liver mice, humans, marmosets, and rabbits, compared to those from monkeys, minipigs, guinea pigs, rats, and mice. Lamotrigine N2-glucuronidation activities in the liver microsomes from humanised-liver mice were dose-dependently inhibited by hecogenin, a specific inhibitor of the human UGT1A4...
October 2021: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://read.qxmd.com/read/34181361/a-single-blind-randomized-comparison-of-lithium-and-lamotrigine-as-maintenance-treatments-for-managing-bipolar-ii-disorder
#17
RANDOMIZED CONTROLLED TRIAL
Gordon Parker, Tahlia Ricciardi, Gabriela Tavella, Dusan Hadzi-Pavlovic
PURPOSE/BACKGROUND: No study to date has compared lithium and lamotrigine as maintenance mood stabilizers for bipolar II disorder. The aim of this study was to evaluate and compare these two medications in terms of their maintenance efficacy and side effect profile, thus evaluating their comparative cost/benefit profile. METHODS/PROCEDURES: Forty-four subjects with a newly diagnosed bipolar II disorder were randomly assigned to receive either lithium or lamotrigine treatment in a 20-week single-blinded study...
July 2021: Journal of Clinical Psychopharmacology
https://read.qxmd.com/read/34092825/lamotrigine-and-stevens-johnson-syndrome-prevention
#18
REVIEW
Amber N Edinoff, Long H Nguyen, Mary Jo Fitz-Gerald, Erin Crane, Kyle Lewis, Samantha St Pierre, Alan D Kaye, Adam M Kaye, Jessica S Kaye, Rachel J Kaye, Sonja A Gennuso, Giustino Varrassi, Omar Viswanath, Ivan Urits
Stevens-Johnson Syndrome (SJS) is a rare life-threatening condition characterized by severe mucocutaneous epidermal necrolysis and detachment of the epidermis. The condition centers around a delayed-type hypersensitivity reaction with a complex etiology stemming from a variety of causes. The number one cause is medication-related-common ones including sulfonamides, antiepileptics, allopurinol, and nonsteroidal anti-inflammatory drugs. Genetics also play a role as several human leukocyte antigen (HLA) genotypes within certain ethnic groups have been implicated in adverse reactions to specific drugs...
March 16, 2021: Psychopharmacology Bulletin
https://read.qxmd.com/read/34070216/possible-antidepressant-effects-of-memantine-systematic-review-with-a-case-study
#19
REVIEW
Marek Krzystanek, Stanisław Surma, Artur Pałasz, Monika Romańczyk, Krzysztof Krysta
The treatment of bipolar depression is hampered by the inadequate efficacy of antidepressants, moderate effect of mood stabilizers, and the side effects of some second-generation antipsychotics. There is limited evidence to date regarding the antidepressant effects of memantine in bipolar depression. The aim of the article was to provide a short review of preclinical and clinical studies on the antidepressant effect of memantine, and to present the case of a bipolar depression patient successfully treated with memantine...
May 18, 2021: Pharmaceuticals
https://read.qxmd.com/read/33978231/-drug-induced-mania-and-hypomania-analysis-of-a-case-of-lamotrigine-induced-mania
#20
A Pereira-Pinto, R F Palma-Álvarez, G Ortega-Hernández, L Grau-López, J A Ramos-Quiroga
INTRODUCTION: Lamotrigine is an antiepileptic medication approved as a mood stabilizer for the prevention of depressive episodes in bipolar disorder. Among its adverse reactions, it may present maniac symptoms, despite being an idiosyncratic adverse effect and low incidence. CASE REPORT: We present the case of a 58-year-old patient, diagnosed with bipolar disorder since her youth and who has required multiple therapeutic schemes. After a pharmacological change from lithium to lamotrigine in progressive ascending doses, she presented a mania decompensation, temporally consistent with the initiation of lamotrigine, and that was accentuated with increasing dose...
May 16, 2021: Revista de Neurologia
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