keyword
https://read.qxmd.com/read/38443970/operative-treatment-of-pulmonary-primitive-neuroectodermal-tumor-a-case-report-and-literature-review
#1
REVIEW
Yiyuan Zhang, Ke Shang, Jialin Li, Mengyao Sun, Xiaoying Gu
BACKGROUND: Pulmonary primitive neuroectodermal tumor (PNET), a member of the Ewing sarcoma family of tumors, is a rare malignancy that is associated with a grim prognosis. To date, fewer than 30 cases of pulmonary PNET have been reported. In this case report, we present the clinical details of a 12-year-old girl with pulmonary PNET who underwent surgical treatment. We also conducted an analysis and summary of other relevant studies and the surgical outcomes. CASE PRESENTATION: In May 2018, a 12-year-old girl was admitted with symptoms of cough and blood-tinged phlegm...
March 5, 2024: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/38411074/the-causal-relationship-between-gut-microbiota-and-neuroblastoma-a-bidirectional-mendelian-randomization-analysis-and-meta-analysis
#2
JOURNAL ARTICLE
Zexin Zhang, Dongting Li, Fengxi Xie, Haibo Zhang
Neuroblastoma (NB) is a type of neuroectodermal tumor that originates from primitive sympathetic ganglion cells. Although many risk factors contributing to the occurrence of NB have been reported in recent years, the role of the gut microbiota in its development remains unclear. A bidirectional Mendelian randomization (MR) analysis was conducted to elucidate the causal relationship between the gut microbiota and NB. In the MR analysis, we employed the inverse-variance weighted (IVW) method as the primary criterion for assessing causality, while also utilizing three additional approaches, including MR-Egger, weighted median model, and weighted mode, for comprehensive evaluation...
February 27, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38390790/-18-f-fdg-pet-ct-imaging-for-treatment-response-assessment-of-cardiac-primitive-neuroectodermal-tumor
#3
JOURNAL ARTICLE
Mehmet Emin Mavi, Murat Fani Bozkurt
Primitive neuroectodermal tumors (PNETs) are rare and aggressive members of the small round cell carcinoma family. Generally, PNETs are classified into two main groups: PNETs of the central nervous system and PNETs of the peripheral nervous system. Herein, we report the therapy response assessment of a rare case of isolated cardiac PNET using 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) imaging. Given that physiological cardiac FDG uptake is typically observed, assessing FDG avid lesions in the myocardium presents a challenge for FDG PET/CT...
February 22, 2024: Molecular Imaging and Radionuclide Therapy
https://read.qxmd.com/read/38315310/top-ihc-ish-hacks-for-and-molecular-surrogates-of-poorly-differentiated-sinonasal-small-round-cell-tumors
#4
REVIEW
Diana Bell
BACKGROUND: Poorly differentiated sinonasal small round cell tumors (SRCTs) are rare and heterogeneous, posing challenges in diagnosis and treatment. METHODS: Recent advances in molecular findings and diagnostic refinement have promoted better understanding and management of these tumors. RESULTS: The newly defined and emerging sinonasal entities demonstrate diverse morphologies, specific genomic signatures, and clinical behavior from conventional counterparts...
February 5, 2024: Head and Neck Pathology
https://read.qxmd.com/read/38213377/primitive-neuroectodermal-tumor-presenting-with-a-large-subcapsular-hematoma-in-pregnancy-a-case-report-and-current-literature-review
#5
Patrick Curtin, Kyler W Perry, Gabrielle Yankelevich, Robert L Grubb
Primitive neuroectodermal tumors (PNET) are rare, small round cell tumors that are difficult to diagnose. It is important to identify PNET early, utilizing immunohistochemistry and genetic markers, as it is often an aggressive cancer. PNET is most commonly described in men between the ages of 20 and 40, with very few case reports highlighting the development in pregnant patients. We present a case of localized renal PNET in a pregnant patient and highlight the diagnostic work-up and treatment as well as the relationship between pregnancy and the potential development of aggressive tumors...
December 2023: Curēus
https://read.qxmd.com/read/38189167/treatment-outcomes-in-patients-with-ewing-sarcoma-of-the-spine-in-a-resource-challenged-setting-17-year-experience-from-a-single-center-in-india
#6
JOURNAL ARTICLE
Archana Sasi, Sindhura Chitikela, Shuvadeep Ganguly, Bivas Biswas, Deepam Pushpam, Akash Kumar, Shah Alam Khan, Venkatesan Sampath Kumar, Shashank Sharad Kale, Ahitagni Biswas, Adarsh Barwad, Asit Ranjan Mridha, Sanjay Thulkar, Sameer Bakhshi
Ewing sarcoma (ES) of the spine is a rare childhood cancer with sparse literature on treatment outcomes. We aimed to describe survival outcomes and prognostic factors in patients with spinal ES treated at a single institute in a resource-challenged setting. We conducted a retrospective analysis of patients with spinal ES registered at a tertiary care oncology center between 2003-2019. Clinical patient data was retrieved from hospital records. Cox regression analysis was used to identify the association of baseline clinical parameters with event free survival (EFS) and overall survival (OS)...
January 8, 2024: Pediatric Hematology and Oncology
https://read.qxmd.com/read/38098564/malignant-gastrointestinal-neuroectodermal-tumor-a-case-report-and-literature-review
#7
Dan Su, Hujuan Yang, Ming Zhao, Hongying Zhou, Jin Wu, Zhongkuo Zhao, Jianguo Zhong, Qian Xue, Yupeng Hong, Jie Sun, Xiaoyi Li, Tongwei Zhao
INTRODUCTION AND IMPORTANCE: A malignant gastrointestinal neuroectodermal tumor (GNET) is an extremely rare primary malignant mesenchymal tumor of the gastrointestinal tract characterized by EWSR1 gene rearrangement. An optimal systemic treatment strategy for advanced/recurrent GNET has not yet been identified. CASE PRESENTATION: A 24-year-old male patient was hospitalized with abdominal pain and underwent two operations for a tumor in his small intestine. Immunohistochemistry (IHC) showed strong expression of S-100 protein and SOX 10...
December 2023: Annals of Medicine and Surgery
https://read.qxmd.com/read/38097381/transformed-testicular-teratoma-to-embryonic-type-neuroectodermal-tumor-with-metastasis-to-mediastinum
#8
JOURNAL ARTICLE
Alanna Siegenthaler, Stephanie Niforatos, Taylor Loon, Amy Brady, Michael Sandhu, Oleksandr Kravtsov, Komal Akhtar
Testicular teratomas may present in both prepubertal and adult men; however, the prognosis differs greatly between these 2 populations. In children, teratomas (prepubertal type) most often occur before the age of 4, are generally seen in their pure form, and behave in a benign fashion. In adults (postpubertal type), teratomas are usually part of a mixed germ cell tumor, and they have the potential to be found at metastatic sites, especially following chemotherapy for non-teratomatous germ cell tumor. Analyses of metastases from germ cell tumors and teratomas from the same patient have demonstrated a high degree of concordance in the observed genetic abnormalities...
2023: Journal of Investigative Medicine High Impact Case Reports
https://read.qxmd.com/read/38088722/partial-hepatectomy-using-linear-cutter-stapler-are-there-advantages
#9
JOURNAL ARTICLE
Marcio Fernandes Chedid, Pietro Waltrick Brum, Tomaz de Jesus Maria Grezzana-Filho, Rafaela Kathrine da Silva, Pedro Funari Pereira, Aljamir Duarte Chedid, Cleber Rosito Pinto Kruel
BACKGROUND: Morbidity of liver resections is related to intraoperative bleeding and postoperative biliary fistulas. The Endo-GIA stapler (EG) in liver resections is well established, but its cost is high, limiting its use. The linear cutting stapler (LCS) is a lower cost device. AIMS: To report open liver resections, using LCS for transection of the liver parenchyma and en bloc stapling of vessels and bile ducts. METHODS: Ten patients were included in the study...
2023: Brazilian Archives of Digestive Surgery: ABCD
https://read.qxmd.com/read/38002476/neoadjuvant-chemotherapy-with-laser-interstitial-thermal-therapy-in-central-nervous-system-neuroblastoma-illustrative-case-and-literature-review
#10
Jason E Chung, Omar Iqbal, Chandra Krishnan, Virginia Harrod, Elizabeth Tyler-Kabara, Rongze O Lu, Winson S Ho
Primitive neuroectodermal tumors of the central nervous system, or CNS neuroblastoma, are rare neoplasms in children. Recently, methylation profiling enabled the discovery of four distinct entities of these tumors. The current treatment paradigm involves surgical resection followed by chemotherapy and radiation. However, upfront surgical resection carries high surgical morbidity in this patient population due to their young age, tumor vascularity, and often deep location in the brain. We report a case of CNS neuroblastoma that can be successfully treated with neoadjuvant chemotherapy followed by minimally invasive laser interstitial thermal therapy and radiation...
October 26, 2023: Brain Sciences
https://read.qxmd.com/read/37956418/spinal-metastases-of-pineal-region-glioblastoma-with-primitive-neuroectodermal-features-highlighting-the-importance-of-molecular-diagnoses-illustrative-case
#11
JOURNAL ARTICLE
Aaryan Shah, Neelan J Marianayagam, Aroosa Zamarud, David J Park, Amit R Persad, Scott G Soltys, Steven D Chang, Anand Veeravagu
BACKGROUND: Glioblastoma (GBM) is the most common primary brain tumor with poor patient prognosis. Spinal leptomeningeal metastasis has been rarely reported, with long intervals between the initial discovery of the primary tumor in the brain and eventual spine metastasis. OBSERVATIONS: Here, the authors present the case of a 51-year-old male presenting with 7 days of severe headache, nausea, and vomiting. Magnetic resonance imaging of the brain and spine demonstrated a contrast-enhancing mass in the pineal region, along with spinal metastases to T8, T12, and L5...
November 13, 2023: J Neurosurg Case Lessons
https://read.qxmd.com/read/37953453/primary-intracranial-ewing-sarcoma-with-ewsr1-fli1-gene-translocation-mimicking-a-meningioma-and-a-multidisciplinary-therapeutic-approach-a-case-report-and-systematic-review-of-literatures
#12
Changjun Hyun, Yeonju Lee, Ho Kang, Hyun Joo Park, Koung Jin Suh, Byung Se Choi, Gheeyoung Choe, Chae-Yong Kim
Ewing sarcoma and peripheral primitive neuroectodermal tumor (ES/pPNET) is an undifferentiated malignant tumor that is most prevalent in children and young adults and often radiologically mimics a meningioma. A 38-year-old female patient visited our hospital with complaints of right-sided tinnitus, right hemiparesis, and imbalance. She underwent preoperative imaging and was subsequently diagnosed as having a meningioma on the petrous ridge. After partial resection, EWSR1-FLI1 gene fusion was confirmed, and she was diagnosed with ES/pPNET...
October 2023: Brain Tumor Research and Treatment
https://read.qxmd.com/read/37909999/osteosarcoma-arising-after-ewing-sarcoma-or-vice-versa-a-report-of-20-affected-patients-from-the-cooperative-osteosarcoma-study-group-coss
#13
JOURNAL ARTICLE
Stefan S Bielack, Claudia Blattmann, Wolf Hassenpflug, Leo Kager, Thomas Kuhne, Matthias Kevric, Paul-Gerhardt Schlegel, Vanessa Mettmann, Benjamin Sorg, Stefanie Hecker-Nolting
BACKGROUND/AIM: Ewing sarcoma can arise in patients after osteosarcoma or vice versa. Our aim was to learn more about which patients develop these secondary tumors, which treatments may be effective, and which patients might survive. PATIENTS AND METHODS: The database of the Cooperative Osteosarcoma Study Group (1980-09/2022) was searched for all patients with an osteosarcoma (including undifferentiated pleomorphic sarcoma of the bone) who also suffered from Ewing sarcoma (incl...
November 2023: Anticancer Research
https://read.qxmd.com/read/37887113/functionalized-gd2-electrochemical-immunosensor-to-diagnose-minimum-residual-disease-of-bone-marrow-in-neuroblastoma-effectively
#14
JOURNAL ARTICLE
Chong Chen, Chang Hu, Baixun He, Yongchang Bai, Feng He, Shuang Li, Cherie S Tan
Neuroblastoma (NB) is known as the "king of childhood tumors" due to its highly metastatic, recurrence-prone, and difficult-to-treat characteristics. International Neuroblastoma Risk Grading Group (INRG) has recommended GD2, a disialoganglioside expressed on neuroectodermal tumor cells, as the target for detecting minimal residual disease in bone marrow metastases of high-risk neuroblastoma in children. Therefore, accurately identifying GD2-positive cells is crucial for diagnosing children with high-risk NB...
October 10, 2023: Biosensors
https://read.qxmd.com/read/37829338/case-report-the-activity-of-multi-kinase-vegf-inhibitor-pazopanib-in-metastatic-undifferentiated-round-cell-sarcomas-harboring-ewsr1-crem-fusion-clinicopathological-series-of-two-cases-and-literature-review
#15
Leticia Campoverde, Felipe Camacho, Francesco Alessandrino, Mark G Evans, Andrew Elliot, Andrew Rosenberg, Jonathan Trent
Soft tissue sarcomas harboring EWSR1::CREM fusion are rare and challenging to treat. Pazopanib, a multi-tyrosine kinase inhibitor, is FDA-approved for advanced soft tissue sarcomas, but predictive biomarkers for its efficacy remain unidentified. We conducted a study on > 240,000 neoplasms submitted to Caris Life Sciences (Phoenix, AZ) to detect rearrangements using whole transcriptome sequencing. Two sarcoma-experienced, board-certified pathologists performed histological reviews, and treatment/outcome information was collected...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37664090/a-primary-ewing-s-sarcoma-of-the-kidney-a-case-report-and-review-of-literature
#16
Ornsinee Senkhum, Worapat Attawettayanon, Choosak Pripatnanont, Virote Chalieopanyarwong
Primary Ewing's kidney sarcoma is a rare and aggressive cancer with poor treatment outcomes. Furthermore, clinical presentations are nonspecific, such as abdominal pain, abdominal mass, cachexia, or hematuria. Currently, there is no consensus guideline for the treatment of this condition. We report on a 22-year-old man who presented with gross hematuria for 3 weeks. Computed tomography demonstrated a huge right renal mass with a thrombus in the inferior vena cava (IVC) without visceral metastasis. A percutaneous tissue biopsy revealed Ewing's sarcoma (ES) and the patient received neoadjuvant chemotherapy (doxorubicin and ifosfamide) for four cycles...
2023: Urology Annals
https://read.qxmd.com/read/37575766/malignant-carotid-paraganglioma-a-case-report
#17
Maani M Archang, Seung Lee, Ismail Ziu, William Clifton, David A Miller, Mark E Jentoft, Jeffrey R Janus
Carotid body tumors (CBTs) are rare neoplasms of the neuroectoderm accounting for 0.6% of head and neck tumors, with a 2%-12.5% risk of malignancy. While surgical resection has been associated with a high rate of neurologic and vascular complications, it remains the mainstay of treatment for malignant CBTs. We present the case of a 40-year-old female with a 5-year history of progressively enlarging right-sided neck mass, with MRI and MRA showing a Shamblin grade III CBT encasement of the internal carotid artery (ICA)...
July 2023: Curēus
https://read.qxmd.com/read/37551252/a-rare-but-aggressive-malignancy-a-case-report-of-a-gastrointestinal-neuroectodermal-tumor-gnet
#18
Shahzeb Saeed, Han Grezenko, Lyba Nisar, Abdur Rehman, Amina Riyaz, Daniel E Cook, Muhammad Kamran
Gastrointestinal neuroectodermal tumors (GNETs) are extremely rare and intriguing malignancies originating from neural crest cells in the digestive tract. The digestive tract's neural crest cells can give rise to incredibly unusual and interesting gastrointestinal neuroectodermal tumors (GNETs). GNETs present considerable hurdles in diagnosis and management because of their rarity and varied expression. In this case report, a 45-year-old male patient is described who had signs of GNET, such as exhaustion, weight loss, and abdominal pain...
July 2023: Curēus
https://read.qxmd.com/read/37527675/stereotactic-radiosurgery-for-distant-brain-metastases-secondary-to-esthesioneuroblastoma-a-single-institution-series
#19
JOURNAL ARTICLE
Aroosa Zamarud, Ulas Yener, Kelly H Yoo, David J Park, Neelan J Marianayagam, Quoc-Anh Ho, Erqi Pollom, Scott Soltys, Lei Wang, Steven D Chang, Antonio Meola
OBJECTIVE: Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare, malignant tumor of neuroectodermal origin that arises from the olfactory neuroepithelium. In this study the authors present the first series in the literature on distant brain metastases (BMs) secondary to ENB that were treated with stereotactic radiosurgery (SRS), to evaluate the safety and effectiveness of SRS for this indication. METHODS: A retrospective analysis of clinical and radiological outcomes of patients with ENB who underwent CyberKnife (CK) SRS at a single center was conducted...
August 2023: Neurosurgical Focus
https://read.qxmd.com/read/37452940/embryonal-tumors-of-the-central-nervous-system-with-multilayered-rosettes-and-atypical-teratoid-rhabdoid-tumors
#20
JOURNAL ARTICLE
Margarita Kamenova, Radka Kaneva, Kamelia Genova, Nikolay Gabrovsky
The 2016 WHO classification of tumors of the central nervous system affected importantly the group of CNS embryonal tumors. Molecular analysis on methylome, genome, and transcriptome levels allowed better classification, identification of specific molecular hallmarks of the different subtypes of CNS embryonal tumors, and their more precise diagnosis. Routine application of appropriate molecular testing and standardized reporting are of pivotal importance for adequate prognosis and treatment, but also for epidemiology studies and search for efficient targeted therapies...
2023: Advances in Experimental Medicine and Biology
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