keyword
https://read.qxmd.com/read/38518998/the-challenge-of-downstream-processing-of-spray-dried-amorphous-solid-dispersions-into-minitablets-designed-for-the-paediatric-population-a-sustainable-product-development-approach
#21
JOURNAL ARTICLE
Anja Autzen Virtanen, Monika Myślińska, Anne Marie Healy, Eoin Power, Atif Madi, Mia Sivén
Poorly water-soluble drugs present a significant challenge in the development of oral solid dosage forms (OSDs). In formulation development the appropriate use of excipients to adjust solubility, and the choice of manufacturing method and pharmaceutical processes to obtain a dosage form to meet the needs of the patient group, is crucial. Preparing an amorphous solid dispersion (ASD) is a well-established method for solubility enhancement, and spray drying (SD) a common manufacturing method. However, the poor flowability of spray dried materials poses a significant challenge for downstream processing...
March 20, 2024: European Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38518667/organ-growth-and-fermentation-profiles-of-broilers-differing-in-body-growth-rate
#22
JOURNAL ARTICLE
Brad Gorenz, Maci L Oelschlager, Julianna C Jespersen, Chang Cao, Alexandra H Smith, Roderick I Mackie, Ryan N Dilger
This study sought to determine the relationship among broiler performance, organ development, and indicators of microbiota colonization. A total of 1,200 two-day-old male Ross 308 broiler chicks, divided among 3 cohorts of equal size, were housed in battery cages, and allotted based on body weight. On study d 11, birds were weighed, and birds with BW gain within the 10th and 90th percentiles were assigned to the Slow and Fast groups, respectively. Birds (n = 30 for each group) selected on d 11 were provided water and a corn-soybean meal-based diet ad libitum while maintained individually through study d 25 (i...
March 7, 2024: Poultry Science
https://read.qxmd.com/read/38518406/large-reductions-in-nutrient-losses-needed-to-avoid-future-coastal-eutrophication-across-europe
#23
JOURNAL ARTICLE
Aslıhan Ural-Janssen, Carolien Kroeze, Erik Meers, Maryna Strokal
Rapid technological development in agriculture and fast urbanization have increased nutrient losses in Europe. High nutrient export to seas causes coastal eutrophication and harmful algal blooms. This study aims to assess the river exports of nitrogen (N) and phosphorus (P), and identify required reductions to avoid coastal eutrophication in Europe under global change. We modelled nutrient export by 594 rivers in 2050 for a baseline scenario using the new MARINA-Nutrients model for Europe. Nutrient export to European seas is expected to increase by 13-28% under global change...
March 15, 2024: Marine Environmental Research
https://read.qxmd.com/read/38517487/a-novel-in-situ-method-for-linear-alkylbenzene-sulfonate-quantification-in-environmental-samples-using-a-digital-image-based-method
#24
JOURNAL ARTICLE
Helayne S de Sousa, Roxanny Arruda-Santos, Eliete Zanardi-Lamardo, Willian T Suarez, Josiane L de Oliveira, Renata A Farias, Vagner Bezerra Dos Santos
Surfactants from detergents, when inadequately treated in sewage treatment plants, are carried away into estuaries, resulting in the contamination of aquatic environments. It is thus necessary to develop rapid and efficient techniques that are capable of effectively monitoring these pollutants. In this context, for the first time in the literature, this study reports the development and application of a digital image-based (DIB) method for the in situ quantification of the anionic surfactant linear alkylbenzene sulfonate (LAS) in water bodies using a smartphone...
March 22, 2024: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/38516095/structure-and-dynamics-of-liquid-water-from-ab-initio-simulations-adding-minnesota-density-functionals-to-jacob-s-ladder
#25
JOURNAL ARTICLE
Justin Villard, Martin P Bircher, Ursula Rothlisberger
The accurate representation of the structural and dynamical properties of water is essential for simulating the unique behavior of this ubiquitous solvent. Here we assess the current status of describing liquid water using ab initio molecular dynamics, with a special focus on the performance of all the later generation Minnesota functionals. Findings are contextualized within the current knowledge on DFT for describing bulk water under ambient conditions and compared to experimental data. We find that, contrary to the prevalent idea that local and semilocal functionals overstructure water and underestimate dynamical properties, M06-L, revM06-L, and M11-L understructure water, while MN12-L and MN15-L overdistance water molecules due to weak cohesive effects...
March 20, 2024: Chemical Science
https://read.qxmd.com/read/38513431/analysis-of-vitamin-d-and-its-metabolites-in-biological-samples-part-i-optimization-and-comparison-of-uhpsfc-ms-ms-and-uhplc-ms-ms-methods
#26
JOURNAL ARTICLE
Veronika Pilařová, Bárbara Socas-Rodríguez, Lucie Nováková, Sofia Essén, Cecilia Holm, Charlotta Turner, Margareta Sandahl
Fat-soluble vitamin D is an essential bioactive compound important for human health. Insufficient vitamin D levels can result not only in bone disease but also in other disorders, such as cancer, metabolic disorders, and diseases related to poor immune function. The current methods commonly used for vitamin D analysis are often applied to determine the levels of the most abundant metabolite in plasma, i.e., 25-OH-D2 /D3 . These methods do not consider the presence of other hydroxylated and esterified metabolites, including isomers and epimers, which are typically found in low concentrations...
March 12, 2024: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/38512704/achieving-controllable-and-reversible-snap-through-in-pre-strained-strips-of-liquid-crystalline-elastomers
#27
JOURNAL ARTICLE
James T Waters, Anna C Balazs
Deformable, elastic materials that buckle in response to external stimuli can display "snap-through", which involves a transition between different, stable buckled states. Snap-through produces a quick release of stored potential energy, and thus can provide fast actuation for soft robots and other flexible devices. Liquid crystalline elastomers (LCEs) exposed to light undergo a phase transition and a concomitant mechanical deformation, allowing control of snap-through for rapid, large amplitude actuation. Using both a semi-analytical model and finite element simulations, we focus on a thin LCE strip that is clamped at both ends and buckles due to an initially imposed strain...
March 21, 2024: Soft Matter
https://read.qxmd.com/read/38512454/investigating-the-influence-of-solvent-type-and-ph-on-protein-adsorption-onto-silica-surface-by-evanescent-wave-cavity-ring-down-spectroscopy
#28
JOURNAL ARTICLE
Shadi A Alnaanah, Sergio B Mendes
Several studies have explored the adsorption of various proteins onto solid-liquid interfaces, revealing the crucial role of buffer solutions in biological processes. However, a comprehensive evaluation of the buffer's influence on protein absorption onto fused silica is still lacking. This study employs evanescent-wave cavity ring-down spectroscopy (EW-CRDS) to assess the influence of buffer solutions and pH on the adsorption kinetics of three globular proteins: hemoglobin (Hb), myoglobin (Mb), and cytochrome c (Cyt-C) onto fused silica...
March 21, 2024: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://read.qxmd.com/read/38512410/on-the-simulation-and-interpretation-of-substrate-water-exchange-experiments-in-photosynthetic-water-oxidation
#29
JOURNAL ARTICLE
Petko Chernev, A Orkun Aydin, Johannes Messinger
Water oxidation by photosystem II (PSII) sustains most life on Earth, but the molecular mechanism of this unique process remains controversial. The ongoing identification of the binding sites and modes of the two water-derived substrate oxygens ('substrate waters') in the various intermediates (Si states, i = 0, 1, 2, 3, 4) that the water-splitting tetra-manganese calcium penta-oxygen (Mn4 CaO5 ) cluster attains during the reaction cycle provides central information towards resolving the unique chemistry of biological water oxidation...
March 21, 2024: Photosynthesis Research
https://read.qxmd.com/read/38511828/restricted-rotational-flexibility-of-the-c5%C3%AE-methyl-substituted-carbapenem-na-1-157-leads-to-potent-inhibition-of-the-ges-5-carbapenemase
#30
JOURNAL ARTICLE
Nichole K Stewart, Marta Toth, Pojun Quan, Michael Beer, John D Buynak, Clyde A Smith, Sergei B Vakulenko
Carbapenem antibiotics are used as a last-resort treatment for infections caused by multidrug-resistant bacteria. The wide spread of carbapenemases in Gram-negative bacteria has severely compromised the utility of these drugs and represents a serious public health threat. To combat carbapenemase-mediated resistance, new antimicrobials and inhibitors of these enzymes are urgently needed. Here, we describe the interaction of the atypically C5α-methyl-substituted carbapenem, NA-1-157, with the GES-5 carbapenemase...
March 21, 2024: ACS Infectious Diseases
https://read.qxmd.com/read/38508757/ethambutol-inhibited-the-growth-of-acid-fast-bacteria-and-enhanced-the-detection-of-legionella-in-environmental-water-samples
#31
JOURNAL ARTICLE
Hiroaki Inoue, Marin Taguchi, Manami Kitazume, Yukie Saito, Tomoyuki Iwasawa
The growth of acid-fast bacteria often hinders the detection of Legionella in water samples on agar plates by the plate culture method. We studied whether anti-tubercular agents inhibit acid-fast bacteria growth on agar plates. First, the antimicrobial activities of isoniazid, ethionamide, and ethambutol were evaluated against Mycobacterium and Legionella. We found that ethambutol at ≥ 100 μg/mL completely inhibited Mycobacterium growth, but ethambutol at 1,000 μg/mL did not inhibit Legionella growth...
2024: J Microorg Control
https://read.qxmd.com/read/38507802/3d-bioprinting-of-stromal-cells-laden-artificial-cornea-based-on-visible-light-crosslinkable-bioinks-forming-multilength-networks
#32
JOURNAL ARTICLE
Gyeong Won Lee, Ajeesh Chandrasekharan, Subhadeep Roy, Akash Thamarappalli, Binapani Mahaling, Hyeseon Lee, Keum-Yong Seong, Sourabh Ghosh, Seung Yun Yang
3D bioprinting has the potential for the rapid and precise engineering of hydrogel constructs that can mimic the structural and optical complexity of a healthy cornea. However, the use of existing light-activated bioinks for corneal printing is limited by their poor cytocompatibility, use of cytotoxic photoinitiators, low photo-crosslinking efficiency, and opaque/colored surface of the printed material. Herein, we report a fast-curable, non-cytotoxic, optically transparent bioprinting system using a new water-soluble benzoyl phosphinate-based photoinitiator and photocrosslinkable methacrylated hyaluronic acid (HAMA)...
March 20, 2024: Biofabrication
https://read.qxmd.com/read/38506404/rim-based-binding-of-perfluorinated-acids-to-pillararenes-purifies-water
#33
JOURNAL ARTICLE
Tu-Nan Gao, Si Huang, Rick Nooijen, Yumei Zhu, Gabriele Kociok-Köhn, Tobias Stuerzer, Guanna Li, Harry Bitter, Gert Salentijn, Bo Chen, Fedor M Miloserdov, Han Zuilhof
Per- and polyfluoroalkyl substances (PFAS) pose a rapidly increasing global problem as their widespread use and high stability lead worldwide to water contamination, with significant detrimental health effects.[1] Supramolecular chemistry has been invoked to develop materials geared towards the specific capture of PFAS from water,[2] to reduce the concentration below advisory safety limits (e.g., 70 ng/L for the sum of perfluorooctyl sulfonic acid, PFOS and perfluorooctanoic acid, PFOA). Scale-up and use in natural waters with high PFAS concentrations has hitherto posed a problem...
March 20, 2024: Angewandte Chemie
https://read.qxmd.com/read/38506072/a-portable-smartphone-platform-utilizing-dual-sensing-signals-for-visual-determination-of-semicarbazide-in-food-samples
#34
JOURNAL ARTICLE
Lingyun Wang, Bihong Lai, Xueguang Ran, Hao Tang, Derong Cao
Semicarbazide (SEM) is a metabolite of antibiotic nitrofurazone and a food contaminant in food production, showing potential carcinogenic, mutagenic, teratogenic, and toxic effects on human health. It is urgent to develop a highly efficient and sensitive assay for visual detection of SEM. In this paper, a pyrrolopyrrole cyanine fluorescent probe (PPCy-1) was reported for visualization and quantitative analysis of SEM through a chromophore reaction sensing mechanism for the first time. The probe towards SEM exhibited a fast response (10 min), a low detection limit (0...
March 20, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/38502244/assessing-the-impact-of-anthropogenic-activities-on-land-use-and-land-cover-changes-in-the-semi-arid-and-arid-regions-of-algeria
#35
JOURNAL ARTICLE
Ghefar Mohammed, Morsli Boutkhil, Bouazzaoui Ayoub
Land use and land cover are critical factors that influence the environment and human societies. The dynamics of LULC have been constantly changing over the years, and these changes can be analyzed at different spatial and temporal scales to evaluate their impact on the natural environment. This study employs multitemporal satellite data to investigate the spatial and temporal transformations that occurred in Sidi Bel Abbes province, situated in the northwestern region of Algeria, spanning from the early 1990s to 2020...
March 19, 2024: Environmental Monitoring and Assessment
https://read.qxmd.com/read/38502238/unveiling-synergistic-qtls-associated-with-slow-wilting-in-soybean-glycine-max-l-merr
#36
JOURNAL ARTICLE
Hakyung Kwon, Moon Young Kim, Xuefei Yang, Suk-Ha Lee
A stable QTL qSW_Gm10 works with a novel locus, qSW_Gm01, in a synergistic manner for controlling slow-wilting traits at the early vegetative stage under drought stress in soybean. Drought is one of the major environmental factors which limits soybean yield. Slow wilting is a promising trait that can enhance drought resilience in soybean without additional production costs. Recently, a Korean soybean cultivar SS2-2 was reported to exhibit slow wilting at the early vegetative stages. To find genetic loci responsible for slow wilting, in this study, quantitative trait loci (QTL) analysis was conducted using a recombinant inbred line (RIL) population derived from crossing between Taekwangkong (fast-wilting) and SS2-2 (slow-wilting)...
March 19, 2024: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://read.qxmd.com/read/38501395/integrating-mid-infrared-spectroscopy-machine-learning-and-graphical-bias-correction-for-fatty-acid-prediction-in-water-buffalo-milk
#37
JOURNAL ARTICLE
Zhiqiu Yao, Wenna Zou, Xinxin Zhang, Pei Nie, Haimiao Lv, Wei Wang, Xuhong Zhao, Ying Yang, Liguo Yang
BACKGROUND: Buffalo milk, constituting 15% of global production, has higher fatty acids content than Holstein milk.Fourier transform mid-infrared spectroscopy (FT-MIR) is widely used for dairy analysis, but its application to buffalo milk, with larger fat globules, remains understudied. The ultimate goal of this study is to develop machine learning models based on FT-MIR for predicting fatty acids in buffalo milk and to assess the accuracy of commercial milk analyzers. This research provides a convenient, fast, and environmentally friendly method for detecting the fatty acid composition in buffalo milk...
March 19, 2024: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/38501275/recent-advances-in-the-development-and-applications-of-luminescent-bacteria-based-biosensors
#38
REVIEW
Yingying Li, Yuankun Zhao, Yiyang Du, Xuechun Ren, He Ding, Zhimin Wang
Luminescent bacteria-based biosensors are widely used for fast and sensitive monitoring of food safety, water quality, and other environmental pollutions. Recent advancements in biomedical engineering technology have led to improved portability, integration, and intelligence of these biotoxicity assays. Moreover, genetic engineering has played a significant role in the development of recombinant luminescent bacterial biosensors, enhancing both detection accuracy and sensitivity. This review provides an overview of recent advances in the development and applications of novel luminescent bacteria-based biosensors, and future perspectives and challenges in the cutting-edge research, market translation, and practical applications of luminescent bacterial biosensing are discussed...
March 2024: Luminescence: the Journal of Biological and Chemical Luminescence
https://read.qxmd.com/read/38500623/one-step-hydrothermal-synthesis-of-a-ni-3-s-2-femoo-4-nanowire-nanosheet-heterostructure-array-for-synergistically-boosted-oxygen-evolution-reaction
#39
JOURNAL ARTICLE
Han Chen, Jing Zhang, Rui Wan, Xiang Zhang, Qijun Pan, Mingtao Li, Bin Chen
A key factor for boosting oxygen evolution reaction (OER) is the design of heterostructures with steerable defects and interfaces, which can optimize the surface electronic structures and achieve efficient water splitting to produce hydrogen fuel. Herein, we propose a novel one-step hydrothermal approach to fabricate hierarchical Ni3 S2 nanowires with an S-doped FeMoO4 nanosheet heterostructure array in situ on Ni-Fe foam (NFF) as a self-standing electrode for synergistically boosted OER. The metalloid Ni3 S2 nanowires with good conductivity support the FeMoO4 nanosheets and act as high-speed paths for the charge transfer...
March 14, 2024: RSC Advances
https://read.qxmd.com/read/38500611/highly-specific-colorimetric-detection-based-on-aggregation-of-l-cysteine-functionalized-gold-nanoparticles-for-cypermethrin-in-water-samples
#40
JOURNAL ARTICLE
Thitima Rujiralai, Nitchakarn Leelaharat, Wilairat Cheewasedtham
A fast, simple, and selective colorimetric assay for quantifying cypermethrin in water samples is proposed using l-cysteine functionalized gold nanoparticles (AuNPs@Cyst). Cypermethrin is hydrolyzed by potassium hydroxide to obtain hydrolyzed cypermethrin in the form of 3-phenoxybenzaldehyde by-product (HCy). The detection strategy is based on the aggregation of AuNPs@Cyst caused by hydrogen-bonding recognition between the aldehyde group of HCy and the amine group of l-cysteine on the surface of AuNPs@Cyst...
March 14, 2024: RSC Advances
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