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https://www.readbyqxmd.com/read/29133921/metabolomics-identifies-metabolite-biomarkers-associated-with-acute-rejection-after-heart-transplantation-in-rats
#1
Feng Lin, Yi Ou, Chuan-Zhong Huang, Sheng-Zhe Lin, Yun-Bin Ye
The aim of this study was to identify metabolite biomarkers associated with acute rejection after heart transplantation in rats using a LC-MS-based metabolomics approach. A model of heterotopic cardiac xenotransplantation was established in rats, with Wistar rats as donors and SD rats as recipients. Blood and cardiac samples were collected from blank control rats (Group A), rats 5 (Group B) and 7 days (Group C) after heart transplantation, and pretreated rats 5 (Group D) and 7 days (Group E) post-transplantation for pathological and metabolomics analyses...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29132732/the-role-of-artificial-and-natural-sweeteners-in-reducing-the-consumption-of-table-sugar-a-narrative-review
#2
REVIEW
Arshag D Mooradian, Meridith Smith, Masaaki Tokuda
The rapid increase in the prevalence of obesity worldwide has been partially attributed to the overconsumption of added sugars. Recent guidelines call for limiting the consumption of simple sugars to less than 10% of daily caloric consumption. High intensity sweeteners are regulated as food additives and include aspartame, acesulfame-k, neotame, saccharin, sucralose, cyclamate and alitame. Steviol glycosides and Luo Han Guo fruit extracts are high intensity sweeteners that are designated as generally recognized as safe (GRAS)...
April 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29121933/biochemical-analysis-and-the-preliminary-crystallographic-characterization-of-d-tagatose-3-epimerase-from-rhodobacter-sphaeroides
#3
Zhengliang Qi, Zhangliang Zhu, Jian-Wen Wang, Songtao Li, Qianqian Guo, Panpan Xu, Fuping Lu, Hui-Min Qin
BACKGROUND: D-Tagatose 3-epimerase epimerizes D-fructose to yield D-psicose, which is a rare sugar that exists in small quantities in nature and is difficult to synthesize chemically. We aim to explore potential industrial biocatalysts for commercial-scale manufacture of this rare sugar. A D-tagatose 3-epimerase from Rhodobacter sphaeroides (RsDTE) has recently been identified as a D-tagatose 3-epimerase that can epimerize D-fructose to yield D-psicose with a high conversion rate. RESULTS: The purified RsDTE by Ni-affinity chromatography, ionic exchange chromatography and gel filtration forms a tetramer in solution...
November 9, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29115611/d%C3%A2-tagatose-inhibits-the-growth-and-biofilm-formation-of-streptococcus%C3%A2-mutans
#4
Khaleque Hasibul, Haruyuki Nakayama-Imaohji, Masahito Hashimoto, Hisashi Yamasaki, Takaaki Ogawa, Junpei Waki, Ayano Tada, Saori Yoneda, Masaaki Tokuda, Minoru Miyake, Tomomi Kuwahara
Dental caries is an important global health concern and Streptococcus mutans has been established as a major cariogenic bacterial species. Reports indicate that a rare sugar, D‑tagatose, is not easily catabolized by pathogenic bacteria. In the present study, the inhibitory effects of D‑tagatose on the growth and biofilm formation of S. mutans GS‑5 were examined. Monitoring S. mutans growth over a 24 h period revealed that D‑tagatose prolonged the lag phase without interfering with the final cell yield...
November 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29059217/prohibition-of-antibiotic-growth-promoters-has-affected-the-genomic-profiles-of-lactobacillus-salivarius-inhabiting-the-swine-intestine
#5
Jun-Yeong Lee, Geon Goo Han, Ho-Bin Lee, Sang-Mok Lee, Sang-Kee Kang, Gwi-Deuk Jin, Jongbin Park, Byung Jo Chae, Yo Han Choi, Eun Bae Kim, Yun-Jaie Choi
After the introduction of a ban on the use of antibiotic growth promoters (AGPs) for livestock, the feeding environment, including the composition of animal intestinal microbiota, has changed rapidly. We hypothesized that the microbial genomes have also been affected by this legal prohibition, and investigated an important member of the swine gut microbiota, Lactobacillus salivarius, with a pan-genomic approach. Here, we isolated 21 L. salivarius strains composed of 6 strains isolated before the AGP prohibition (SBPs) and 15 strains isolated after the AGP prohibition (SAPs) at an interval of a decade, and the draft genomes were generated de novo...
2017: PloS One
https://www.readbyqxmd.com/read/28972169/isomer-activation-controls-stereospecificity-of-class-i-fructose-1-6-bisphosphate-aldolases
#6
Paul W Heron, Jurgen Sygusch
Fructose-1,6-bisphosphate (FBP) aldolase, a glycolytic enzyme, catalyzes the reversible and stereospecific aldol addition of dihydroxyacetone-P (DHAP) and D-glyceraldehyde-3-P (D-G3P) by an unresolved mechanism. To afford insight into the molecular determinants of FBP aldolase stereospecificity during aldol addition, a key ternary complex formed by DHAP and D-G3P, comprising 2 % of the equilibrium population at physiological pH, was cryotrapped in the active site of Toxoplasma gondii aldolase (TgALD) crystals to high resolution...
September 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28940418/rare-sugars-d-allulose-d-tagatose-and-d-sorbose-differently-modulate-lipid-metabolism-in-rats
#7
Yasuo Nagata, Narumi Mizuta, Akane Kanasaki, Kazunari Tanaka
BACKGROUND: Rare sugars including D-allulose, D-tagatose, and D-sorbose are present in limited quantities in nature; some of these rare sugars are now commercially produced using microbial enzymes. Apart from the anti-obesity and anti-hyperglycemic activities of D-allulose, effects of these sugars on lipid metabolism have not been investigated. Therefore, we aimed to determine if and how D-tagatose and D-sorbose modulate lipid metabolism in rats. After feeding these rare sugars to rats, parameters on lipid metabolism were determined...
September 21, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28923717/production-of-d-tagatose-and-bioethanol-from-onion-waste-by-an-intergrating-bioprocess
#8
Ho Myeong Kim, Younho Song, Seung Gon Wi, Hyeun-Jong Bae
The rapid increase of agricultural waste is becoming a burgeoning problem and considerable efforts are being made by numerous researchers to convert it into a high-value resource material. Onion waste is one of the biggest issues in a world of dwindling resource. In this study, the potential of onion juice residue (OJR) for producing valuable rare sugar or bioethanol was evaluated. Purified Paenibacillus polymyxaL-arabinose isomerase (PPAI) has a molecular weight of approximately 53kDa, and exhibits maximal activity at 30°C and pH 7...
September 18, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28805091/a-comparison-of-two-low-calorie-sweeteners-and-sugar-in-dark-chocolate-on-sensory-attributes-and-emotional-conceptualisations
#9
Sofie Lagast, Hans De Steur, Joachim J Schouteten, Xavier Gellynck
Reducing sugar consumption is an important aspect in the prevention of and fight against obesity. A broader understanding of consumers' perceptions of low-calorie sweeteners is needed. This study examined two low-calorie sweeteners, tagatose and stevia, in comparison to sugar in dark chocolate. A total of 219 consumers participated in this study and rated overall liking and sensory attributes. Participants also listed their emotional conceptualisations upon consumption and were assessed on emotional eating behaviour and health and taste attitudes...
August 14, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28690628/comparison-of-salt-tolerance-in-soja-based-on-metabolomics-of-seedling-roots
#10
Mingxia Li, Rui Guo, Yang Jiao, Xiaofei Jin, Haiyan Zhang, Lianxuan Shi
Soybean is an important economic crop that is continually threatened by abiotic stresses, especially salt stress. Wild soybean is an important germplasm resource for the breeding of cultivated soybean. The root system plays a very important role in plant salt tolerance. To explore the salt tolerance-related mechanisms among Soja, we have demonstrated the seedling roots' growth and metabolomics in wild soybean, semi-wild soybean, and cultivated soybean under two types of salt stress by using gas chromatography-mass spectrometry...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28662355/metabolic-engineering-pathways-for-rare-sugars-biosynthesis-physiological-functionalities-and-applications-a-review
#11
Muhammad Bilal, Hafiz M N Iqbal, Hongbo Hu, Wei Wang, Xuehong Zhang
Biomolecules like rare sugars and their derivatives are referred to as monosaccharides particularly uncommon in nature. Remarkably, many of them have various known physiological functions and biotechnological applications in cosmetics, nutrition, and pharmaceutical industries. Also, they can be exploited as starting materials for synthesizing fascinating natural bioproducts with significant biological activities. Regrettably, most of the rare sugars are quite expensive, and their synthetic chemical routes are both limited and economically unfeasible due to expensive raw materials...
June 29, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28549946/potential-metabolomic-biomarkers-for-reliable-diagnosis-of-behcet-s-disease-using-gas-chromatography-with-time-of-flight-mass-spectrometry
#12
Joong Kyong Ahn, Jungyeon Kim, Jiwon Hwang, Juhwan Song, Kyoung Heon Kim, Hoon-Suk Cha
OBJECTIVES: Although many diagnostic criteria of Behcet's disease (BD) have been developed and revised by experts, diagnosing BD is still complicated and challenging. No metabolomic studies on serum have been attempted to improve the diagnosis and to identify potential biomarkers of BD. The purposes of this study were to investigate distinctive metabolic changes in serum samples of BD patients and to identify metabolic candidate biomarkers for reliable diagnosis of BD using the metabolomics platform...
May 23, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28530095/rational-design-of-bacillus-coagulans-nl01-l-arabinose-isomerase-and-use-of-its-f279i-variant-in-d-tagatose-production
#13
Zhaojuan Zheng, Wending Mei, Meijuan Xia, Qin He, Jia Ouyang
d-Tagatose is a prospective functional sweetener that can be produced by l-arabinose isomerase (AI) from d-galactose. To improve the activity of AI toward d-galactose, the AI of Bacillus coagulans was rationally designed on the basis of molecular modeling and docking. After alanine scanning and site-saturation mutagenesis, variant F279I that exhibited improved activity toward d-galactose was obtained. The optimal temperature and pH of F279I were determined to be 50 °C and 8.0, respectively. This variant possessed 1...
June 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28512318/structure-based-prediction-and-identification-of-4-epimerization-activity-of-phosphate-sugars-in-class-ii-aldolases
#14
Seon-Hwa Lee, Seung-Hye Hong, Jung-Ung An, Kyoung-Rok Kim, Dong-Eun Kim, Lin-Woo Kang, Deok-Kun Oh
Sugar 4-epimerization reactions are important for the production of rare sugars and their derivatives, which have various potential industrial applications. For example, the production of tagatose, a functional sweetener, from fructose by sugar 4-epimerization is currently constrained because a fructose 4-epimerase does not exist in nature. We found that class II D-fructose-1,6-bisphosphate aldolase (FbaA) catalyzed the 4-epimerization of D-fructose-6-phosphate (F6P) to D-tagatose-6-phosphate (T6P) based on the prediction via structural comparisons with epimerase and molecular docking and the identification of the condensed products of C3 sugars...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28481935/genotypic-and-phenotypic-characterization-of-multidrug-resistant-salmonella-typhimurium-and-salmonella-kentucky-strains-recovered-from-chicken-carcasses
#15
Rizwana Tasmin, Nur A Hasan, Christopher J Grim, Ar'Quette Grant, Seon Young Choi, M Samiul Alam, Rebecca Bell, Christopher Cavanaugh, Kannan V Balan, Uma S Babu, Salina Parveen
Salmonella Typhimurium is the leading cause of human non-typhoidal gastroenteritis in the US. S. Kentucky is one the most commonly recovered serovars from commercially processed poultry carcasses. This study compared the genotypic and phenotypic properties of two Salmonella enterica strains Typhimurium (ST221_31B) and Kentucky (SK222_32B) recovered from commercially processed chicken carcasses using whole genome sequencing, phenotype characterizations and an intracellular killing assay. Illumina MiSeq platform was used for sequencing of two Salmonella genomes...
2017: PloS One
https://www.readbyqxmd.com/read/28480150/biobased-furanics-kinetic-studies-on-the-acid-catalyzed-decomposition-of-2-hydroxyacetyl-furan-in-water-using-br%C3%A3-nsted-acid-catalysts
#16
J N M Soetedjo, H H van de Bovenkamp, P J Deuss, H J Heeres
Biobased furanics like 5-hydroxymethylfurfural (5-HMF) are interesting platform chemicals for the synthesis of biofuel additives and polymer precursors. 5-HMF is typically prepared from C6 ketoses like fructose, psicose, sorbose and tagatose. A known byproduct is 2-hydroxyacetylfuran (2-HAF), particularly when using sorbose and psicose as the reactants. We here report an experimental and kinetic modeling study on the rate of decomposition of 2-HAF in a typical reaction medium for 5-HMF synthesis (water, Brönsted acid), with the incentive to gain insights in the stability of 2-HAF...
May 1, 2017: ACS Sustainable Chemistry & Engineering
https://www.readbyqxmd.com/read/28458081/reactivity-studies-in-water-on-the-acid-catalysed-dehydration-of-psicose-compared-to-other-ketohexoses-into-5-hydroxymethylfurfural
#17
Robert-Jan van Putten, Jan C van der Waal, Ed de Jong, Hero J Heeres
The conversion of the four possible ketohexoses (fructose, tagatose, sorbose and psicose) into 5-hydroxymethylfurfural (HMF) was explored in water using sulphuric acid as the catalyst (33 mM H2SO4, 120 °C). Significant differences in reactivity were observed and tagatose (48% conversion after 75 min) and psicose (35% conversion after 75 min) were clearly more reactive than fructose and sorbose (around 20% conversion after 75 min). The selectivity to HMF was found to be higher for fructose and psicose than for tagatose and sorbose...
April 13, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28405835/high-yield-production-of-pure-tagatose-from-fructose-by-a-three-step-enzymatic-cascade-reaction
#18
Seon-Hwa Lee, Seung-Hye Hong, Kyoung-Rok Kim, Deok-Kun Oh
OBJECTIVE: To produce tagatose from fructose with a high conversion rate and to establish a high-yield purification method of tagatose from the reaction mixture. RESULTS: Fructose at 1 M (180 g l(-1)) was converted to 0.8 M (144 g l(-1)) tagatose by a three-step enzymatic cascade reaction, involving hexokinase, plus ATP, fructose-1,6-biphosphate aldolase, phytase, over 16 h with a productivity of 9 g l(-1) h(-1). No byproducts were detected. Tagatose was recrystallized from ethanol to a purity of 99...
April 12, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28371762/d-tagatose-production-by-permeabilized-and-immobilized-lactobacillus-plantarum-using-whey-permeate
#19
J Jayamuthunagai, G Srisowmeya, M Chakravarthy, P Gautam
The aim of the work is to produce d-Tagatose by direct addition of alginate immobilized Lactobacillus plantarum cells to lactose hydrolysed whey permeate. The cells were untreated and immobilized (UIC), permeabilized and immobilized (PIC) and the relative activities were compared with purified l-arabinose isomerase (l-AI) for d-galactose isomerization. Successive lactose hydrolysis by β-galactosidase from Escherichia coli and d-galactose isomerization using l-AI from Lactobacillus plantarum was performed to investigate the in vivo production of d-tagatose in whey permeate...
July 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28258150/tm0416-a-hyperthermophilic-promiscuous-nonphosphorylated-sugar-isomerase-catalyzes-various-c5-and-c6-epimerization-reactions
#20
Sun-Mi Shin, Thinh-Phat Cao, Jin Myung Choi, Seong-Bo Kim, Sang-Jae Lee, Sung Haeng Lee, Dong-Woo Lee
There is currently little information on nonphosphorylated sugar epimerases, which are of potential interest for producing rare sugars. We found a gene (the TM0416 gene) encoding a putative d-tagatose-3-epimerase-related protein from the hyperthermophilic bacterium Thermotoga maritima We overexpressed the TM0416 gene in Escherichia coli and purified the resulting recombinant protein for detailed characterization. Amino acid sequence alignment and a structural similarity search revealed that TM0416 is a putative nonphosphorylated sugar epimerase...
May 15, 2017: Applied and Environmental Microbiology
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