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https://www.readbyqxmd.com/read/28813533/18%C3%A3-glycyrrhetinic-acid-derivative-promotes-proliferation-migration-and-aquaporin-3-expression-in-human-dermal-fibroblasts
#1
Chi-Feng Hung, Chien-Yu Hsiao, Wen-Hao Hsieh, Hsin-Ju Li, Yi-Ju Tsai, Chun-Nan Lin, Hsun-Hsien Chang, Nan-Lin Wu
Licorice (Glycyrrhiza) species have been widely used as a traditional medicine and a natural sweetener in foods. The 18β-glycyrrhetinic acid (18β-GA) is a bioactive compound in licorice that exhibits potential anti-cancer, anti-inflammatory, and anti-microbial activities. Many synthesized derivatives of 18β-GA have been reported to be cytotoxic and suggested for the treatment of malignant diseases. In this study, we explored the possible pharmacological roles of an 18β-GA derivative in skin biology using primary human dermal fibroblasts and HaCaT keratinocytes as cell models...
2017: PloS One
https://www.readbyqxmd.com/read/28792778/stevia-rebaudiana-bertoni-a-natural-alternative-for-treating-diseases-associated-with-metabolic-syndrome
#2
Areli Carrera-Lanestosa, Yolanda Moguel-Ordóñez, Maira Segura-Campos
Stevia rebaudiana (SR) is often used by the food industry due to its steviol glycoside content, which is a suitable calorie-free sweetener. Further, both in vitro and in vivo studies indicate that these glycosides and the extracts from SR have pharmacological and therapeutic properties, including antioxidant, antimicrobial, antihypertensive, antidiabetic, and anticancer. This work reviews the antiobesity, antihyperglycemic, antihypertensive, and antihyperlipidemic effects of the majority of glycosides and aqueous/alcoholic extracts from the leaves, flowers, and roots of the SR...
August 9, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28763963/thermoanalytical-study-of-sweetener-myo-inositol-%C3%AE-and-%C3%AE-polymorphs
#3
Rafael Turra Alarcon, Caroline Gaglieri, Flávio Junior Caires, Aroldo Geraldo Magdalena, Ricardo António Esteves de Castro, Gilbert Bannach
This work investigates the thermal behavior of α and β myo-inositol polymorphs. The inositol is a natural compound widely used in the food industry due to its presence in carbohydrate metabolism and its sweet taste. The occurrence of polymorphism could change some physico-chemical properties, such as melting and sublimation temperatures, and solubility. Therefore, the thermal study of polymorphism is important to ensure better conditions for synthesis, storage, and transportation of food that contains the myo-inositol...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28748072/the-evaluation-of-saccharose-replacing-by-adding-stevioside-maltodextrin-mixture-on-the-physicochemical-and-sensory-properties-of-naanberenji-an-iranian-confectionary
#4
Amirpouya Ghandehari Yazdi, Mohammad Hojjatoleslamy, Javad Keramat, Mahshid Jahadi, Elahe Amani
Stevia is a natural, non-nutritive sweetener can replace sugar in your diet to control diabetes and aid in weight loss. Naanberenji, an Iranian traditional cookie, is a well-reputed confectionary containing high sucrose and calorie value, for this reason its consumption in healthy diet has been restricted. In this study, the effect of sucrose replacement by stevioside-maltodextrin mixture on physicochemical properties of Naanberenji was evaluated in four replacing levels including 25%, 50%, 75%, and 100%. Results of texture evaluation revealed that hardness increases due to adding stevioside-maltodextrin (p < ...
July 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28747831/optimization-of-sugar-replacement-with-date-syrup-in-prebiotic-chocolate-milk-using-response-surface-methodology
#5
Sahar Kazemalilou, Ainaz Alizadeh
Chocolate milk is one of the most commonly used non-fermentative dairy products, which, due to high level of sucrose, could lead to diabetes and tooth decay among children. Therefore, it is important to replace sucrose with other types of sweeteners, especially, natural ones. In this research, response surface methodology (RSM) was used to optimize the ingredients formulation of prebiotic chocolate milk, date syrup as sweetener (4-10%w/w), inulin as prebiotic texturizer (0-0.5%w/w) and carrageenan as thickening agent (0-0...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28738695/a-research-on-the-genotoxicity-of-stevia-in-human-lymphocytes
#6
Aslı Uçar, Serkan Yılmaz, Şemsigül Yılmaz, Mustafa Sefa Kılıç
Stevia extracts are obtained from Stevia rebaudiana commonly used as natural sweeteners. It is ∼250-300 times sweeter than sucrose. Common use of stevia prompted us to investigate its genotoxicity in human peripheral blood lymphocytes. Stevia (active ingredient steviol glycoside) was dissolved in pure water. Dose selection was done using ADI (acceptable daily intake) value. Negative control (pure water), 1, 2, 4, 8 and 16 μg/ml concentrations which were equivalent to ADI/4, ADI/2, ADI, ADI × 2 and ADI × 4 of Stevia were added to whole-blood culture...
July 24, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28719376/stability-of-spironolactone-oral-suspension-in-pcca-base-suspendit
#7
Richard Graves, Kelly V Phan, Levon A Bostanian, Tarun K Mandal, Yashoda V Pramar
Spironolactone (Aldactone) is a potassium-sparing diuretic used to treat hypertension and heart failure and may also be used to treat edema resulting from kidney disease, low potassium levels, or excess aldosterone. No commercial liquid dosage form of spironolactone exists. An extemporaneously compounded suspension from pure drug powder or commercial tablets would provide an alternative option to meet unique patient needs. The purpose of this study was to determine the physicochemical stability of spironolactone in the PCCA base SuspendIt...
July 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28709091/evaluating-the-photocatalytic-treatment-of-stevioside-by-tio2-in-different-aqueous-matrices-and-identification-of-transformation-products
#8
V A Sakkas, M Sarro, M Kalaboka, V Santoro, T Albanis, P Calza, C Medana
The present study reports the photocatalytic transformation of stevioside, under simulated solar irradiation using TiO2 as a photocatalyst. As a tool of investigating the effect of various aqueous matrices, as well as, the initial stevioside concentration on the variation of the photocatalytic efficiency, a fully nested experimental design was employed. A significant impact on the degradation rate of the sweetener was observed: degradation rate decreases in the order distilled water>river water>lake water, attributed to the increased natural organic matter content of the respective natural water samples...
July 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28693571/characterization-of-erythrose-reductase-from-yarrowia-lipolytica-and-its-influence-on-erythritol-synthesis
#9
Tomasz Janek, Adam Dobrowolski, Anna Biegalska, Aleksandra M Mirończuk
BACKGROUND: Erythritol is a natural sweetener that is used in the food industry. It is produced as an osmoprotectant by bacteria and yeast. Due to its chemical properties, it does not change the insulin level in the blood, and therefore it can be safely used by diabetics. Previously, it has been shown that erythrose reductase (ER), which catalyzes the final step, plays a crucial role in erythritol synthesis. ER reduces erythrose to erythritol with NAD(P)H as a cofactor. Despite many studies on erythritol synthesis by Yarrowia lipolytica, the enzymes involved in this metabolic pathway have ever been described...
July 11, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28691317/synthesis-and-characterization-of-a-novel-microporous-dihydroxyl-functionalized-triptycene-diamine-based-polyimide-for-natural-gas-membrane-separation
#10
Nasser Alaslai, Xiaohua Ma, Bader Ghanem, Yingge Wang, Fahd Alghunaimi, Ingo Pinnau
An intrinsically microporous polyimide is synthesized in m-cresol by a one-pot high-temperature condensation reaction of 4,4'-(hexafluoroisopropylidene)diphthalic anhydride (6FDA) and newly designed 2,6 (7)-dihydroxy-3,7(6)-diaminotriptycene (DAT1-OH). The 6FDA-DAT1-OH polyimide is thermally stable up to 440 °C, shows excellent solubility in polar solvents, and has moderately high Brunauer-Teller-Emmett (BET) surface area of 160 m(2) g(-1) , as determined by nitrogen adsorption at -196 °C. Hydroxyl functionalization applied to the rigid 3D triptycene-based diamine building block results in a polyimide that exhibits moderate pure-gas CO2 permeability of 70 Barrer combined with high CO2 /CH4 selectivity of 50...
July 10, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28689062/sweeteners-as-food-additives-in-the-xxi-century-a-review-of-what-is-known-and-what-is-to-come
#11
REVIEW
Márcio Carocho, Patricia Morales, Isabel C F R Ferreira
Sweet has always been a very important basic taste for mankind, although sweetness is always related to either weight gain or teeth decay. Sweeteners entered the food industry back in the 1800's and are now staple in foodstuffs. Despite their long relationship with food, sweeteners have been in the spotlights for many reasons. Since being the perfect choice for diabetics, to the dangers concerning toxicity, cancer and other health issues associated with their consumption, sweeteners have come a long way. The conflicting results for the same sweeteners and the divergent regulations are fuel for a wide debate on the impact of sweeteners in the industry, health and lifestyle of mankind...
September 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28685052/effect-of-dark-colored-maple-syrup-on-cell-proliferation-of-human-gastrointestinal-cancer-cell
#12
Tetsushi Yamamoto, Kanta Sato, Yuika Kubota, Kuniko Mitamura, Atsushi Taga
Maple syrup is a natural sweetener that is commonly consumed worldwide. While maple syrup mainly comprises sucrose, it also contains phytochemicals that present various biological effects. Maple syrup is made by boiling down sap, and its color and composition vary in accordance with the sap collection season. Typically, seasonal progression is associated with darker syrup color, and antioxidant activity is proportional to the increasingly dark color. The authors previously reported that maple syrup demonstrated inhibitory effects on colorectal cancer cell growth and invasion, which correlated with darker maple syrup color...
July 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28676578/impact-of-the-north-american-free-trade-agreement-on-high-fructose-corn-syrup-supply-in-canada-a-natural-experiment-using-synthetic-control-methods
#13
COMPARATIVE STUDY
Pepita Barlow, Martin McKee, Sanjay Basu, David Stuckler
BACKGROUND: Critics of free trade agreements have argued that they threaten public health, as they eliminate barriers to trade in potentially harmful products, such as sugar. Here we analyze the North American Free Trade Agreement (NAFTA), testing the hypothesis that lowering tariffs on food and beverage syrups that contain high-fructose corn syrup (HFCS) increased its use in foods consumed in Canada. METHODS: We used supply data from the Food and Agriculture Organization of the United Nations to assess changes in supply of caloric sweeteners including HFCS after NAFTA...
July 4, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28666887/stevia-and-stevioside-protect-against-cisplatin-nephrotoxicity-through-inhibition-of-erk1-2-stat3-and-nf-%C3%AE%C2%BAb-activation
#14
Iva Potočnjak, Dalibor Broznić, Marija Kindl, Matija Kropek, Sanda Vladimir-Knežević, Robert Domitrović
We investigated the effect of natural sweetener Stevia rebaudiana and its constituent stevioside in cisplatin (CP)-induced kidney injury. Male BALB/cN mice were orally administered 10, 20, and 50 mg/kg body weight of Stevia rebaudiana ethanol extract (SE) or stevioside 50 mg/kg, 48 h after intraperitoneal administration of CP (13 mg/kg). Two days later, CP treatment resulted in histopathological changes showing kidney injury. Increased expression of 4-hydroxynonenal (4-HNE), 3-nitrotyrosine (3-NT), and heme oxygenase-1 (HO-1) in mice kidneys suggested oxidative stress...
September 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28664731/biocatalytic-synthesis-of-the-rare-sugar-kojibiose-process-scale-up-and-application-testing
#15
Koen Beerens, Karel De Winter, Davy Van de Walle, Charlotte Grootaert, Senem Kamiloglu, Lisa Miclotte, Tom Van de Wiele, John Van Camp, Koen Dewettinck, Tom Desmet
Cost-efficient (bio)chemical production processes are essential to evaluate the commercial and industrial applications of promising carbohydrates and also are essential to ensure economically viable production processes. Here, the synthesis of the naturally occurring disaccharide kojibiose (2-O-α-d-glucopyranosyl-d-glucopyranoside) was evaluated using different Bifidobacterium adolescentis sucrose phosphorylase variants. Variant L341I_Q345S was found to efficiently synthesize kojibiose while remaining fully active after 1 week of incubation at 55 °C...
July 26, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28663690/role-of-honey-in-modern-medicine
#16
REVIEW
Sultan Ayoub Meo, Saleh Ahmad Al-Asiri, Abdul Latief Mahesar, Mohammad Javed Ansari
Use of honey has a very long history. Honey has been used since ancient time due to its nutritional and therapeutic values. There had been varied ways of consumption honey including its use as a sweetener and flavoring agent. Honey is produced all over the world. The most important nutriment of honey is carbohydrates present in the form of monosaccharides, fructose and glucose. Honey plays an important role as an antioxidant, anti-inflammatory, anti-bacterial agent and augments the adherence of skin grafts and wound healing process...
July 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28655616/functional-identification-of-a-lippia-dulcis-bornyl-diphosphate-synthase-that-contains-a-duplicated-inhibitory-arginine-rich-motif
#17
Matthew C Hurd, Moonhyuk Kwon, Dae-Kyun Ro
Lippia dulcis (Aztec sweet herb) contains the potent natural sweetener hernandulcin, a sesquiterpene ketone found in the leaves and flowers. Utilizing the leaves for agricultural application is challenging due to the presence of the bitter-tasting and toxic monoterpene, camphor. To unlock the commercial potential of L. dulcis leaves, the first step of camphor biosynthesis by a bornyl diphosphate synthase needs to be elucidated. Two putative monoterpene synthases (LdTPS3 and LdTPS9) were isolated from L. dulcis leaf cDNA...
August 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28635032/amino-functionalized-zif-7-nanocrystals-improved-intrinsic-separation-ability-and-interfacial-compatibility-in-mixed-matrix-membranes-for-co2-ch4-separation
#18
Long Xiang, Luqian Sheng, Chongqing Wang, Lixiong Zhang, Yichang Pan, Yanshuo Li
Highly permeable and selective, as well as plasticization-resistant membranes are desired as promising alternatives for cost- and energy-effective CO2 separation. Here, robust mixed-matrix membranes based on an amino-functionalized zeolitic imidazolate framework ZIF-7 (ZIF-7-NH2 ) and crosslinked poly(ethylene oxide) rubbery polymer are successfully fabricated with filler loadings up to 36 wt%. The ZIF-7-NH2 materials synthesized from in situ substitution of 2-aminobenzimidazole into the ZIF-7 structure exhibit enlarged aperture size compared with monoligand ZIF-7...
June 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28628126/consumption-of-sugar-sweetened-beverages-and-type-2-diabetes-incidence-in-thai-adults-results-from-an-8-year-prospective-study
#19
K Papier, C D'Este, C Bain, C Banwell, S Seubsman, A Sleigh, S Jordan
BACKGROUND: The global prevalence of type 2 diabetes mellitus (T2DM) is high and is increasing in countries undergoing rapid socio-economic development, including Thailand. Sugar-sweetened beverage (SSB) intake may contribute to the risk of developing T2DM. However, few studies have assessed this association in Asian populations, and the results have been inconsistent. We aimed to assess that association in a prospective study of Thai adults. METHODS: Data were from Thai Cohort Study participants surveyed in 2005, 2009 and 2013...
June 19, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28618238/antiglycating-potential-of-acesulfame-potassium-an-artificial-sweetener
#20
Ahmad Ali, Tejashree Anil More, Amaritpal Kaur Hoonjan, Subramanian Sivakami
Sweeteners have replaced the natural sugars in the food and beverage industry because of many reasons, such as hyperglycemia and cost. Saccharin, sucralose, aspartame and acesulfame-K are the most commonly used sweeteners. In the present study, the abovementioned artificial sweeteners were used to assess their glycating properties by established methods such as browning, fructosamine assay, determination of carbonyl content, protein aggregation, and measurement of fluorescence. Amadori and advanced glycation end products (AGEs) are formed as a result of the interaction between carbonyl groups of reducing sugars and amino groups of proteins and other macromolecules during glycation...
June 15, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
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