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https://www.readbyqxmd.com/read/29679926/peripheral-artery-disease-a-micro-rna-related-condition
#1
REVIEW
Georgia Vogiatzi, Evangelos Oikonomou, Spyridon Deftereos, Gerasimos Siasos, Dimitris Tousoulis
Peripheral artery disease (PAD) is a vascular problem of diffuse atherosclerosis and is a major cause of cardiovascular morbidity and mortality. Many studies have tried to gain insight into the molecular mechanisms involved in PAD. Lately, highly stable circulating small noncoding RNAs, microRNAs (miRNAs), seem to have disease-specific expression. Thus, miRNAs are emerging as new measurable diagnostic biomarkers and a start point for individualized treatment. To date, the association of miRNA regulation in angiogenesis and maintenance of vascular integrity in PAD has attracted little interest...
April 18, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29679893/identification-of-homocysteine-suppressive-mitochondrial-etc-complex-genes-and-tissue-expression-profile-novel-hypothesis-establishment
#2
Ramon Cueto, Lixiao Zhang, Hui Min Shan, Xiao Huang, Xinyuan Li, Ya-Feng Li, Jahaira Lopez, William Y Yang, Muriel Lavallee, Catherine Yu, Yong Ji, Xiaofeng Yang, Hong Wang
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease (CVD) which has been implicated in matochondrial (Mt) function impairment. In this study, we characterized Hcy metabolism in mouse tissues by using LC-ESI-MS/MS analysis, established tissue expression profiles for 84 nuclear-encoded Mt electron transport chain complex (nMt-ETC-Com) genes in 20 human and 19 mouse tissues by database mining, and modeled the effect of HHcy on Mt-ETC function. Hcy levels were high in mouse kidney/lung/spleen/liver (24-14 nmol/g tissue) but low in brain/heart (~5 nmol/g)...
April 4, 2018: Redox Biology
https://www.readbyqxmd.com/read/29679631/possible-early-detection-of-coronary-artery-calcium-progression-in-type-1-diabetes-a-case-control-study-of-normoalbuminuric-type-1-diabetes-patients-and-matched-controls
#3
Henrik Ø Hjortkjær, Tonny Jensen, Jannik Hilsted, Helle Corinth, Ulrik M Mogensen, Lars Køber, Andreas Fuchs, Børge G Nordestgaard, Klaus F Kofoed
AIMS: Coronary artery calcium (CAC) is associated with cardiovascular (CV) disease and progression of CAC is an independent predictor of mortality. Type 1 diabetes is associated with increased CV risk, especially in persons with cardiovascular autonomic neuropathy (CAN). This study aimed to examine whether short-term progression of CAC is increased in persons with type 1 diabetes compared to matched controls and if CAN increases risk of CAC progression. METHODS: Fifty-three normoalbuminuric persons with long-term type 1 diabetes (20 with CAN) were matched in a 1:2 ratio with 106 controls without diabetes according to age, sex and baseline CAC...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679623/hyperglycemia-in-pregnancy-and-its-implications-for-a-woman-s-future-risk-of-cardiovascular-disease
#4
REVIEW
Ravi Retnakaran
It is well established that gestational diabetes mellitus (GDM) identifies a population of women who are at risk of ultimately developing type 2 diabetes (T2DM) later in life. Moreover, this relationship extends across the full spectrum of hyperglycemia in pregnancy, with lesser degrees of gestational dysglycemia identifying a proportionate gradient of future risk of T2DM. Importantly, a growing body of evidence suggests that an analogous relationship exists between hyperglycemia in pregnancy and a woman's long-term risk of cardiovascular disease (CVD), as well...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679538/cardiovascular-disease-progression-a-target-for-therapy
#5
REVIEW
Jay N Cohn
Clinical research aimed at preventing cardiovascular disease has focused on the effect of interventions to reduce risk factors on the incidence of future morbid events. Disease progression, which likely serves as a necessary prerequisite for morbid events, has not served as a target for therapy. The Rasmussen Center at the University of Minnesota has, for the past 18 years, been performing a non-invasive cardiovascular evaluation in individuals with no history of cardiovascular disease. The studies, performed in one hour in one room, provide a comprehensive non-invasive assessment of the severity of functional and structural abnormalities in the small arteries, the large arteries and the left ventricle, the target organs for most cardiovascular morbid events...
April 18, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29679365/influence-of-gaseous-pollutants-on-copd-exacerbations-in-patients-with-cardiovascular-comorbidities
#6
Michal Zielinski, Mariusz Gasior, Dariusz Jastrzebski, Aneta Desperak, Dariusz Ziora
Exacerbations of chronic obstructive pulmonary disease (COPD) are a serious public health issue. Ambient pollution and meteorological factors are considered among precipitating factors. There are few data concerning the impact of ambient pollutants other than particulates on COPD exacerbations. Among gaseous pollutants four main groups of substances are primarily monitored: nitrogen oxides (NOx), sulphur dioxide (SO2 ), carbon monoxide (CO), and ozone (O3 ). In this study, 12,889 hospitalizations in the years 2006-2014 due to exacerbations of COPD in patients having a co-existing cardiovascular pathology were retrospectively analyzed...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29679333/a-mixed-methods-study-to-examine-the-role-of-psychosocial-stress-and-air-pollution-on-hypertension-in-mexican-origin-hispanics
#7
Amal Rammah, Kristina Walker Whitworth, Inkyu Han, Wenyaw Chan, Maria D Jimenez, Sara S Strom, Melissa L Bondy, Elaine Symanski
PURPOSE: Independent and combined effects of air pollution and psychosocial stressors on hypertension, a risk factor for cardiovascular disease, among Hispanics are not well studied. METHODS: We administered a pilot-tested questionnaire on individual- and neighborhood-level psychosocial stressors, developed with community input, to nearly 2500 individuals from the MD Anderson Cancer Center cohort of Mexican-Americans. We used data from local air quality monitors to estimate individual exposures to ozone (O3 ) and fine particulate matter (PM2...
April 20, 2018: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29679302/association-of-abnormal-serum-potassium-levels-with-arrhythmias-and-cardiovascular-mortality-a-systematic-review-and-meta-analysis-of-observational-studies
#8
REVIEW
Liesa K Hoppe, Dana C Muhlack, Wolfgang Koenig, Prudence R Carr, Hermann Brenner, Ben Schöttker
PURPOSE: To provide the first systematic review and meta-analysis of observational studies on the association of abnormal serum potassium and cardiovascular outcomes. METHODS: Medline and ISI Web of Knowledge were systematically searched from inception until November 24, 2017. Data synthesis of relevant studies was performed using random effects model meta-analyses. RESULTS: Meta-analyses included 310,825 participants from 24 studies. In the older general population, low serum potassium was associated with a 1...
April 20, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29679294/gender-differences-in-home-based-cardiac-rehabilitation-of-post-percutaneous-coronary-intervention-patients
#9
Yong Hwan Kim, Wi-Young So
Cardiac rehabilitation (CR) is a structured program for the prevention of secondary cardiovascular disease (CVD) and related diseases, such as hypertension, diabetes, and obesity. This study aimed to investigate whether there are gender differences after 9 months of home-based cardiac rehabilitation program in post-percutaneous coronary intervention patients. A total of 114 (58.29 ± 10.33 years) men and 30 (60.90 ± 9.32 years) women were enrolled in the CR program. The program included three visits: initial, 4th month (follow-up), and 9th month (final) visits at a CR center...
April 20, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29679162/circulating-troponin-i-level-in-patients-with-acute-ischemic-stroke
#10
REVIEW
Jacob VanHouten, Gregory Fricker, Bridget Collins, Ritwik Bhatia, Christopher Ellis, Matthew Schrag
PURPOSE OF REVIEW: Cardiac troponin levels in the blood are an important biomarker of acute coronary events, but may also be elevated in the context of acute ischemic stroke without an obvious concurrent myocardial insult. The objective of this study and systematic review is to determine how high the circulating troponin I level can rise due to ischemic stroke. RECENT FINDINGS: Anonymized medical records from Vanderbilt University Medical Center were reviewed identifying 151,972 unique acute ischemic stroke events, of which 1226 met criteria for inclusion in this study...
April 20, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29678986/detecting-risk-of-postural-hypotension-drop-derivation-and-validation-of-a-prediction-score-for-primary-care
#11
Christopher Elles Clark, Daniel Thomas, Fiona C Warren, David J Llewellyn, Luigi Ferrucci, John L Campbell
OBJECTIVES: Falls are a common problem in older people. Postural hypotension contributes to falls but is often asymptomatic. In the absence of symptoms, postural hypotension is only infrequently checked for in clinical practice. We undertook this study to derive, validate and explore the prospective associations of a prediction tool to identify people likely to have unrecognised postural hypotension. DESIGN AND SETTING: Cross-sectional and prospective multivariable cohort analysis...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678976/fostering-active-living-and-healthy-eating-through-understanding-physical-activity-and-dietary-behaviours-of-arabic-speaking-adults-a-cross-sectional-study-from-the-middle-east
#12
Tam Truong Donnelly, Tak Shing Fung, Al-Anoud Bint Mohammad Al-Thani
OBJECTIVES: Physical inactivity and unhealthy diets increase the risk for diabetes, cardiovascular diseases and cancer. Many people in Qatar are sedentary and consume diets high in fats, salt and sugar. The purpose of this study was to determine physical activity levels, food habits and understand the variables that might predict physical activity and healthy eating behaviours among Arabic-speaking adults living in the State of Qatar. SETTING: A cross-sectional community-based survey was conducted with 1606 Arab adults ≥18 years of age from March 2013 to June 2015...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678964/technology-enabled-examinations-of-cardiac-rhythm-optic-nerve-oral-health-tympanic-membrane-gait-and-coordination-evaluated-jointly-with-routine-health-screenings-an-observational-study-at-the-2015-kumbh-mela-in-india
#13
Pratik Shah, Gregory Yauney, Otkrist Gupta, Vincent Patalano Ii, Mrinal Mohit, Rikin Merchant, S V Subramanian
OBJECTIVES: Technology-enabled non-invasive diagnostic screening (TES) using smartphones and other point-of-care medical devices was evaluated in conjunction with conventional routine health screenings for the primary care screening of patients. DESIGN: Dental conditions, cardiac ECG arrhythmias, tympanic membrane disorders, blood oxygenation levels, optic nerve disorders and neurological fitness were evaluated using FDA-approved advanced smartphone powered technologies...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678824/metabolic-karma-the-atherogenic-legacy-of-diabetes-the-2017-edwin-bierman-award-lecture
#14
Mark Emmanuel Cooper, Assam El-Osta, Terri Jean Allen, Anna Margareta Dorothea Watson, Merlin Christopher Thomas, Karin Agnes Maria Jandeleit-Dahm
Cardiovascular disease, despite all the recent advances in treatment of the various risk factors, remains the major cause of mortality in both type 1 and type 2 diabetes. Experimental models of diabetes-associated atherosclerosis, despite their limitations in recapitulating the human context, have assisted in the elucidation of molecular and cellular pathways implicated in the development and progression of macrovascular injury in diabetes. Our own studies have emphasized the role of oxidative stress and advanced glycation and identified potential targets for vasoprotective therapies in the setting of diabetes...
May 2018: Diabetes
https://www.readbyqxmd.com/read/29678696/sarcopenic-obesity-revisited-insights-from-the-mr-and-ms-os-cohort
#15
Jean Woo, Jason Leung
OBJECTIVES: Following the concept of a metabolic load-capacity model, we propose the use of appendicular skeletal muscle mass (ASM) to total body fat (TBF) ratio in predicting 4-year physical limitations, physical performance measures, 6-year incident diabetes and cardiovascular diseases, and 12-year mortality. DESIGN: Cross-sectional and prospective cohort study. SETTING AND PARTICIPANTS: 4000 men and women aged 65 years and older living in the community...
April 17, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29678607/association-between-hypertension-and-metabolic-disorders-among-elderly-patients-in-north-jordan
#16
Nuha Alwardat, Laura Di Renzo, Renata Costa de Miranda, Sofian Alwardat, Paola Sinibaldi Salimei, Antonino De Lorenzo
BACKGROUND: Hypertension (HTN), dyslipidemia and hyperglycemia are major risk factors for cardiovascular disease, accounting for the highest morbidity and mortality among the elderly Jordanian population. This study aimed to evaluate serum lipid and glucose profiles of hypertensive patients and normotensive controls, and determine the risk factors for HTN among elderly population in Jordan. METHODS: A cross-sectional study was carried out among 200 participants, including 111 hypertensive patients and 89 normotensive controls from June to October 2017 in North Jordan...
April 12, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29678605/hypoglycemia-in-type-2-dm-patients-review-article
#17
REVIEW
Ayla M Tourkmani, Turki J Alharbi, Abdulaziz M Bin Rsheed, Abdulrhamn N AlRasheed, Saad M AlBattal, Osama Abdelhay, Mohamed A Hassali, Alian A Alrasheedy, Nouf G Al Harbi, Abdulaziz Alqahtani
Hypoglycemia is an essential issue for diabetic patients and considered a limiting factor in the glycemic management. Heterogeneity of the diseases in Type 2 Diabetes Mellitus can affect the frequency of hypoglycemia, especially when the patient has cardiovascular diseases. There are several factors lead to hypoglycemia sulfonylurea therapy, insulin therapy, delayed or missed a meal, physical exercise, or drug or alcohol consumption. Long-term studies reported that repeated hypoglycemia is increasing the risk of cardiovascular disease...
April 12, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29678447/mediterranean-diet-and-cardiovascular-disease-prevention-what-do-we-know
#18
REVIEW
Jordi Salas-Salvadó, Nerea Becerra-Tomás, Jesús Francisco García-Gavilán, Mònica Bulló, Laura Barrubés
Cardiovascular disease (CVD) morbidity and mortality is increasing, representing an important public health issue worldwide. It is well-known that risk of CVD is substantially influenced by lifestyle, including poor diet, tobacco smoking and physical inactivity. In the last years, the so-called Mediterranean Diet (MedDiet) has been associated with broad healthy benefits on human health, including protection against CVD. The present narrative review aimed to summarize and discuss the evidence from meta-analyses of epidemiological and clinical trials analyzing MedDiet and CVD risk...
April 17, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29678294/association-between-body-mass-index-and-clinical-outcomes-of-patients-after-cardiac-arrest-and-resuscitation-a-meta-analysis
#19
REVIEW
Ye Ma, Lili Huang, Lu Zhang, Hai Yu, Bin Liu
BACKGROUND: Obesity as one of the risk factors for cardiovascular diseases increases mortality in general population. Several clinical studies investigated clinical outcomes in patients with different body mass index (BMI) after cardiac arrest (CA). Controversial data regarding BMI on clinical outcomes in those patients exist in those studies. Therefore, we conducted a meta-analysis to evaluate the effect of BMI on survival condition and neurological prognosis in those patients. METHODS: We searched Pubmed, Embase, Ovid/Medline and EBM reviews databases for relational studies investigating the association between BMI and clinical outcomes of patients after CA...
April 6, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29678183/a-randomized-controlled-cross-over-trial-investigating-the-effect-of-anti-inflammatory-diet-on-disease-activity-and-quality-of-life-in-rheumatoid-arthritis-the-anti-inflammatory-diet-in-rheumatoid-arthritis-adira-study-protocol
#20
Anna Winkvist, Linnea Bärebring, Inger Gjertsson, Lars Ellegård, Helen M Lindqvist
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects 0.5-1.0% of the population, and where many patients in spite of modern pharmacological treatment fail to reach remission. This affects physical as well as mental wellbeing and leads to severely reduced quality of life and reduced work capacity, thus yielding high individual as well as societal costs. As a complement to modern pharmacological treatment, lifestyle intervention should be evaluated as a treatment option...
April 20, 2018: Nutrition Journal
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