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Cardiovascular disease risk

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https://www.readbyqxmd.com/read/29913486/prognostic-implications-of-single-sample-confirmatory-testing-for-undiagnosed-diabetes-a-prospective-cohort-study
#1
Elizabeth Selvin, Dan Wang, Kunihiro Matsushita, Morgan E Grams, Josef Coresh
Background: Current clinical definitions of diabetes require repeated blood work to confirm elevated levels of glucose or hemoglobin A1c (HbA1c) to reduce the possibility of a false-positive diagnosis. Whether 2 different tests from a single blood sample provide adequate confirmation is uncertain. Objective: To examine the prognostic performance of a single-sample confirmatory definition of undiagnosed diabetes. Design: Prospective cohort study...
June 19, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29912869/reporting-bias-in-the-literature-on-the-associations-of-health-related-behaviors-and-statins-with-cardiovascular-disease-and-all-cause-mortality
#2
Leandro Fórnias Machado de Rezende, Juan Pablo Rey-López, Thiago Hérick de Sá, Nicholas Chartres, Alice Fabbri, Lauren Powell, Emmanuel Stamatakis, Lisa Bero
Reporting bias in the literature occurs when there is selective revealing or suppression of results, influenced by the direction of findings. We assessed the risk of reporting bias in the epidemiological literature on health-related behavior (tobacco, alcohol, diet, physical activity, and sedentary behavior) and cardiovascular disease mortality and all-cause mortality and provided a comparative assessment of reporting bias between health-related behavior and statin (in primary prevention) meta-analyses. We searched Medline, Embase, Cochrane Methodology Register Database, and Web of Science for systematic reviews synthesizing the associations of health-related behavior and statins with cardiovascular disease mortality and all-cause mortality published between 2010 and 2016...
June 18, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29912831/idiopathic-sudden-sensorineural-hearing-loss-is-not-a-sentinel-event-for-acute-myocardial-infarction
#3
Matthew G Crowson, Hillary Mulder, Derek D Cyr, Alan W Langman, Walter T Lee, Kourosh Parham, Melissa A Pynnonen, Kristine Schulz, Jennifer J Shin, David Witsell, Andrea Vambutas
OBJECTIVE: Given ongoing debate about the suggested association, the primary objective was to determine if idiopathic sudden sensorineural hearing loss (ISSNHL) was a sentinel event for acute myocardial infarction (AMI) in adults. STUDY DESIGN: Case-control study. SETTING: United States MarketScan administrative health claims database. PATIENTS: Aged 18 years or older, had a diagnosis of ISSNHL on or after January 1st, 2011 and had sufficient follow-up data available to assess for AMI occurrence...
June 15, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29912803/association-of-fatty-liver-index-with-the-risk-of-incident-cardiovascular-disease-and-acute-myocardial-infarction
#4
Olubunmi O Olubamwo, Jyrki K Virtanen, Ari Voutilainen, Jussi Kauhanen, Jussi Pihlajamäki, Tomi-Pekka Tuomainen
BACKGROUND: Fatty liver disease (FLD) has been identified as constituting cardiometabolic risk. However, evidence on the association of fatty liver index (FLI) with cardiovascular disease (CVD) is largely cross-sectional, with limited evidence on the predictability of incident CVD, and specifically, acute myocardial infarction (AMI). Therefore, we aimed to investigate the prospective associations between fatty liver as estimated by FLI and incident CVD, and specifically AMI, in the Kuopio Ischaemic Heart Disease Risk Factor Study cohort...
June 16, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29912783/impact-of-serum-lipoprotein-a-on-endothelium-dependent-coronary-vasomotor-response-assessed-by-intracoronary-acetylcholine-provocation
#5
Ahmed Mashaly, Seung-Woon Rha, Byoung G Choi, Man J Baek, Yang G Ryu, Se Y Choi, Jae K Byun, Kareem Abdelshafi, Yoonjee Park, Won Y Jang, Kim Woohyeun, Eun J Park, Jah Yeon Choi, Jin O Na, Cheol U Choi, Hong E Lim, Eung J Kim, Chang G Park, Hong S Seo
BACKGROUND: Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic vascular disease. However, there are limited data regarding the impact of Lp(a) levels on the incidence and severity of endothelium-dependent coronary vasomotor response. PATIENTS AND METHODS: A total of 2416 patients without significant coronary artery lesion (<50% stenosis) by coronary angiography and underwent acetylcholine (ACh) provocation test were enrolled and categorized according to their serum Lp(a) level into four quartile groups: less than 6...
June 16, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29912406/changes-in-biomarkers-of-exposure-on-switching-from-a-conventional-cigarette-to-tobacco-heating-products-a-randomized-controlled-study-in-healthy-japanese-subjects
#6
Nathan Gale, Mike McEwan, Alison C Eldridge, Ian M Fearon, Neil Sherwood, Edward Bowen, Simon McDermott, Emma Holmes, Andrew Hedge, Stuart Hossack, Louise Wakenshaw, James Glew, Oscar M Camacho, Graham Errington, John McAughey, James Murphy, Chuan Liu, Christopher J Proctor
Background: Smoking is a leading cause of numerous human disorders including pulmonary disease, cardiovascular disease, and cancer. Disease development is primarily caused by exposure to cigarette smoke constituents, many of which are known toxicants. Switching smokers to modified risk tobacco products (MRTPs) has been suggested as a potential means to reduce the risks of tobacco use, by reducing such exposure. Methods: This randomized, controlled study investigated whether biomarkers of toxicant exposure (BoE) were reduced when smokers switched from smoking combustible cigarettes to using a novel (glo™/THP1...
June 15, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29912235/-peripartum-cardiomyopathy-a-little-known-disease
#7
Angela Beatrice Scardovi, Renata De Maria
Peripartum cardiomyopathy (PPCM) is a relatively rare cardiac disease that manifests itself in the final stage of pregnancy and in the first months after delivery in women with no previous history of cardiovascular disease. The incidence of PPCM varies widely across geographic areas and seems to be on the rise as a result of increased awareness and socioeconomic changes. PPCM recognizes a still partially undefined multifactorial etiology. Various pathogenetic hypotheses have been proposed, that range from autoimmune mechanisms to myocarditis to the hormonal hypothesis for aberrant, antiangiogenic and cardiotoxic prolactin (PRL) production, apoptosis, prolonged exposure to tocolytic drugs, malnutrition and genetic predisposition...
April 2018: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29912156/vasodilator-activity-of-compounds-isolated-from-plants-used-in-mexican-traditional-medicine
#8
Francisco J Luna-Vázquez, César Ibarra-Alvarado, María Del Rayo Camacho-Corona, Alejandra Rojas-Molina, J Isela Rojas-Molina, Abraham García, Moustapha Bah
Arterial hypertension is one of the main risk factors in the development of cardiovascular diseases. Therefore, it is important to look for new drugs to treat hypertension. In this study, we carried out the screening of 19 compounds (triterpenes, diterpenes, sesquiterpenes, lignans, and flavonoids) isolated from 10 plants used in Mexican traditional medicine to determine whether they elicited vascular smooth muscle relaxation and, therefore, could represent novel anti-hypertension drug candidates. The vasorelaxant activity of these compounds was evaluated on the isolated rat aorta assay and the results obtained from this evaluation showed that three compounds induced a significant vasodilatory effect: meso -dihydroguaiaretic acid [half maximal effective concentration (EC50 ), 49...
June 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29911393/renal-and-cardiac-implications-of-sodium-glucose-cotransporter-2-sglt2-inhibitors-the-state-of-the-science
#9
Joseph E Cruz, Tania Ahuja, Mary Barna Bridgeman
OBJECTIVE: To review the role of the sodium-glucose cotransporter-2 (SGLT2) inhibitors in the management of type 2 diabetes (T2DM), including the effects on renal and cardiovascular (CV) outcomes. DATA SOURCES: A literature search of MEDLINE databases (1964 through May 2018) was conducted utilizing key words sodium-glucose co-transporter-2 inhibitors, SGLT2 inhibitors, and diabetes; additional limits for drug names were added. STUDY SELECTION AND DATA EXTRACTION: Available English-language data from reviews, abstracts, presentations, and clinical trials of use of SGLT2 therapy specifically detailing outcomes on CV and renal disease in humans were reviewed...
June 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29911105/genetics-of-cardiovascular-disease-fishing-for-causality
#10
REVIEW
Christoph Paone, Federica Diofano, Deung-Dae Park, Wolfgang Rottbauer, Steffen Just
Cardiovascular disease (CVD) is still the leading cause of death in all western world countries and genetic predisposition in combination with traditional risk factors frequently mediates their manifestation. Genome-wide association (GWA) studies revealed numerous potentially disease modifying genetic loci often including several SNPs and associated genes. However, pure genetic association does not prove direct or indirect relevance of the modifier region on pathogenesis, nor does it define within the associated region the exact genetic driver of the disease...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29911036/assessment-of-cardiovascular-risk-in-natural-and-surgical-menopause
#11
S Zafar Abbas, Vijayata Sangawan, Asim Das, Anil Kumar Pandey
Background: Menopause is associated with increased cardiovascular disease (CVD) risk. Arterial stiffness, a biomarker of vascular aging, increases the risk for CVD. Aims and Objectives: The study was aimed to determine whether menopause is associated with arterial stiffness amongst natural and surgical menopausal women. Materials and Methods: We conducted a cross-sectional study amongst natural postmenopausal women, with Surgical menopause and Premenopausal...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29911035/subclinical-hypothyroidism-and-cardiac-risk-lessons-from-a-south-indian-population-study
#12
Sashi Niranjan Nair, Harish Kumar, Manoj Raveendran, V Usha Menon
Introduction: The benefits of treating subclinical hypothyroidism are currently under debate, prevention of adverse cardiac events purporting to be one of the main benefits. The effect of subclinical hypothyroidism on the cardiovascular health of the Indian sub-population is largely unknown. This study was designed to examine these effects and to help guide treatment of this disorder. Methods: A cross-sectional adult population survey was carried out in urban coastal area of central Kerala...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29911003/bicuspid-aortic-valve-registry-of-the-italian-society-of-echocardiography-and-cardiovascular-imaging-registro-della-valvola-aortica-bicuspide-della-societ%C3%A3-italiana-di-ecocardiografia-e-cardiovascular-imaging-rationale-and-study-design
#13
Rodolfo Citro, Moreno Cecconi, Salvatore La Carrubba, Eduardo Bossone, Francesco Antonini-Canterin, Stefano Nistri, Fabio Chirillo, Ilaria Dentamaro, Michele Bellino, Alfredo Posteraro, Mauro Giorgi, Licia Petrella, Ines Monte, Vincenzo Manuppelli, Antonio Mantero, Scipione Carerj, Frank Benedetto, Paolo Colonna
Background: Bicuspid aortic valve (BAV) is the most common congenital heart disease, affecting 0.5%-2% of the general population. It is associated not only with notable valvular risk (aortic stenosis and/or regurgitation, endocarditis) but also with aortopathy with a wide spectrum of unpredictable clinical presentations, including aneurysmal dilation of the aortic root and/or ascending thoracic aorta, isthmic coarctation, aortic dissection, or wall rupture. Methods: The REgistro della Valvola Aortica Bicuspide della Società Italiana di ECocardiografia e CArdiovascular Imaging is a retrospective (from January 1, 2010)/prospective, multicenter, observational registry, expected to enroll 3000 patients with definitive diagnosis of BAV made by transthoracic and/or transesophageal echocardiography, computed tomography, cardiovascular magnetic resonance, or at surgery...
April 2018: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29910818/potential-immunological-links-between-psoriasis-and-cardiovascular-disease
#14
REVIEW
Aparna P Sajja, Aditya A Joshi, Heather L Teague, Amit K Dey, Nehal N Mehta
Preclinical and clinical research provide strong evidence that chronic, systemic inflammation plays a key role in development and progression of atherosclerosis. Indeed, chronic inflammatory diseases, such as psoriasis, are associated with accelerated atherosclerosis and increased risk of cardiovascular events. Contemporary research has demonstrated plausible mechanistic links between immune cell dysfunction and cardiometabolic disease in psoriasis. In this review, we describe the role of potential common immunological mechanisms underlying both psoriasis and atherogenesis...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29910627/performance-of-body-mass-index-and-percentage-of-body-fat-in-predicting-cardiometabolic-risk-factors-in-thai-adults
#15
Somlak Vanavanan, Pornpen Srisawasdi, Mana Rochanawutanon, Nalinee Kumproa, Khanat Kruthkul, Martin H Kroll
Background: Body mass index (BMI) and percentage of body fat (PBF) are used to measure obesity; however, their performance in identifying cardiometabolic risk in Southeast Asians is unclear. Generally, Asian women have higher PBF and lower BMI than do men and other ethnic populations. This study was conducted to address whether a discord exists between these measures in predicting obesity-related cardiometabolic risk in a Thai population and to test whether associations between the measures and risk factors for cardiovascular disease have a sex-specific inclination...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29910607/medical-and-laboratory-assessment-for-regular-blood-donors-in-sulaimani-blood-bank-iraq
#16
Hisham Arif Getta, Hemn Abed Ahmad, Heshu Sulaiman Rahman, Govand Ali Ahmed, Rasedee Abdullah
Introduction: It has been suggested that blood donation reduces risks of developing cardiovascular diseases such as heart failure, atherosclerosis, and stroke. Although there are known benefits of blood donation, the inclination of people of the Kurdistan Region of Iraq to donate blood is not known. Therefore, the aim of this study was to determine demograpic and blood biochemical profiles of regular and first-time blood donors in the Sulaimani province of North Iraq. Methods: A cross-sectional study was conducted at the Sulaimani Blood Bank, during the period of April 1, 2016 to March 28, 2017, on convenient samples of 100 regular and 100 first-time blood donors...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29910605/role-of-etelcalcetide-in-the-management-of-secondary-hyperparathyroidism-in-hemodialysis-patients-a-review-on-current-data-and-place-in-therapy
#17
REVIEW
Claudia Friedl, Emanuel Zitt
Secondary hyperparathyroidism (sHPT) is a frequently occurring severe complication of advanced kidney disease. Its clinical consequences include extraskeletal vascular and valvular calcifications, changes in bone metabolism resulting in renal osteodystrophy, and an increased risk of cardiovascular morbidity and mortality. Calcimimetics are a cornerstone of parathyroid hormone (PTH)-lowering therapy, as confirmed by the recently updated 2017 Kidney Disease: Improving Global Outcomes chronic kidney disease - mineral and bone disorder clinical practice guidelines...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29910469/work-ability-of-aging-teachers-in-bulgaria
#18
Katya Vangelova, Irina Dimitrova, Bistra Tzenova
OBJECTIVES: The work ability of aging teachers is of special interest because of high risk of stress. The aim of the study was to follow the work ability of aging teachers and compare it with that of aging non-teacher professionals. MATERIAL AND METHODS: The study included 424 teachers of age ≤ 44 years old (N = 140) and ≥ 45 years old (N = 284), with about 10% male teachers in both age groups, matched by sex and age with non-teacher professionals. Work ability was assessed by means of the Work Ability Index (WAI)...
June 8, 2018: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29910067/assessment-of-cardiovascular-risk-and-social-framework-of-cape-verdean-university-students-studying-in-portugal
#19
Liliana Tavares, Conceição Calhau, Jorge Polónia
INTRODUCTION: The migration of African populations to Europe poses problems of adaptation that may increase the risk of cardiovascular disease. We assessed the cardiovascular risk of Cape Verdean university students studying in Portugal (CV-PT) compared to Cape Verdean university students in Cape Verde (CV-CV) and to Caucasian university students in Portugal (PT-PT). METHODS: A cross-sectional study was performed comparing three university populations, 54-62% female, aged 19-28 years: CV-PT (n=104), CV-CV (n=100) and PT-PT (n=100)...
June 14, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29910052/incidence-timing-and-type-of-first-and-recurrent-ischemic-events-in-patients-with-and-without-peripheral-artery-disease-after-an-acute-coronary-syndrome
#20
Taku Inohara, Karen Pieper, Daniel M Wojdyla, Manesh R Patel, William Schuyler Jones, Pierluigi Tricoci, Kenneth W Mahaffey, Stefan K James, John H Alexander, Renato D Lopes, Lars Wallentin, Erik Magnus Ohman, Matthew T Roe, Sreekanth Vemulapalli
BACKGROUND: Patients with peripheral artery disease (PAD) are known to have an increased risk of ischemic cardiovascular events. However, the influence of concomitant PAD on first and subsequent recurrent ischemic events after an acute coronary syndrome (ACS) remains poorly characterized. METHODS: We analyzed the combined data set from 4 randomized trials (PLATO, APPRAISE-2, TRA-CER, and TRILOGY ACS) in ACS for a follow-up length of 1 year. Using multivariable regression, we examined the association between PAD and major adverse cardiovascular events, a composite of cardiovascular death, myocardial infarction, and stroke...
July 2018: American Heart Journal
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