Ning Ding, Chao Yang, Shoshana H Ballew, Corey A Kalbaugh, John W McEvoy, Maya Salameh, David Aguilar, Ron C Hoogeveen, Vijay Nambi, Elizabeth Selvin, Aaron R Folsom, Gerardo Heiss, Josef Coresh, Christie M Ballantyne, Kunihiro Matsushita
OBJECTIVE: Inflammatory markers, such as hs-CRP (high-sensitivity C-reactive protein), have been reported to be related to peripheral artery disease (PAD). Galectin-3, a biomarker of fibrosis, has been linked to vascular remodeling and atherogenesis. However, its prospective association with incident PAD is unknown; as is the influence of inflammation on the association between galectin-3 and PAD. Approach and Results: In 9851 Atherosclerosis Risk in Communities Study participants free of PAD at baseline (1996-1998), we quantified the association of galactin-3 and hs-CRP with incident PAD (hospitalizations with PAD diagnosis [ International Classification of Diseases - Ninth Revision : 440...
July 23, 2020: Arteriosclerosis, Thrombosis, and Vascular Biology