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platelets transfusion in dengue

Ajeet Kumar Gadhwal, B S Ankit, Chitresh Chahar, Pankaj Tantia, P Sirohi, R P Agrawal
OBJECTIVE: Thrombocytopenia in dengue fever is a common and serious complication. However, no specific treatment is available for dengue fever induced thrombocytopenia. In few countries (Pakistan, Malaysia, Sri Lanka and other Asian countries) the leaf extract of Carica papaya has been effectively used for thrombocytopenia. So, the study is planned to access effect of Carica papaya leaf extract on platelet count in dengue fever patients. METHODS: All participants were randomised into two groups, study group and control group; the study group was given papaya leaf extract capsule of 500 mg once daily and routine supportive treatment for consecutive five days...
June 2016: Journal of the Association of Physicians of India
Kulwinder Lal
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Rajesh Deshwal, Md Ishaque Qureshi, Raj Singh
OBJECTIVE: Dengue fever is one of the most common arboviral mediated outbreaks reported with increased prevalence year after year with considerable morbidity and mortality. This study was designed to assess the clinical and biochemical parameters of dengue fever patients. METHODS: Prospective observational study was undertaken among adult patients in a military hospital. Five hundred fiteen patients were studied and analysed. All patients who were NS1 antigen/IgM dengue positive were included in the study...
December 2015: Journal of the Association of Physicians of India
Amoolya Bhat, Vijaya Chowdappa, Smita Surendra Masamatti
INTRODUCTION: Dengue affects more than 50 million people per year and is one of the most common causes of severe thrombocytopaenia. Thrombocytopaenia is a common complication of dengue and other viral fevers apart from malaria, typhoid, leptospirosis, leukaemia and megaloblastic anaemia. A platelet count of <20,000/μl is characteristically seen in dengue haemorrhagic fever and dengue fever. It results from immune complex mediated platelet destruction or bone marrow suppression. Severe thrombocytopaenia <10,000/μl is one of the indications for prophylactic platelet transfusion therapy to prevent haemorrhage...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Hsin-Wei Huang, Han-Chi Tseng, Chih-Hung Lee, Hung-Yi Chuang, Shang-Hung Lin
OBJECTIVES: To assess whether the cutaneous features in patients with dengue fever are associated with abnormal blood biochemistry, complications, and poor disease outcome. METHODS: Forty five patients with dengue fever were identified at a medical center in Kaohsiung, Taiwan, from September to November 2014. All cases were exclusively caused by type 1 dengue virus. Patients were classified into two groups, based on the presence or absence of skin rash, and their rash was subclassified into maculopapular, morbilliform, and petechial types...
July 2016: Asian Pacific Journal of Tropical Medicine
Maria L Barjas-Castro, Rodrigo N Angerami, Mariana S Cunha, Akemi Suzuki, Juliana S Nogueira, Iray M Rocco, Adriana Y Maeda, Fernanda G S Vasami, Gizelda Katz, Ilka F S F Boin, Raquel S B Stucchi, Mariângela R Resende, Danillo L A Esposito, Renato P de Souza, Benedito A da Fonseca, Marcelo Addas-Carvalho
BACKGROUND: Zika virus (ZIKV) is an emerging arthropod-borne flavivirus transmitted by Aedes mosquitoes. Recent commentaries regarding ZIKV routes of transmission describe a potential transmission by transfusion. Herein, we report a probable case of transfusion-transmitted ZIKV infection through a platelet transfusion that was detected from postdonation information. CASE REPORT: A blood donor made a voluntary telephone report to the blood donor facility 3 days after donation and informed the facility of a febrile illness (fever, malaise, and headaches)...
July 2016: Transfusion
Savadogo Mamoudou, Boushab Mohamed Boushab
Dengue is a re-emerging arboviral disease in tropical countries. Haemorrhagic form may be associated with circulatory failure and produce hypovolemic shock, which is often fatal. We report a series of three cases of hemorrhagic dengue observed at the Infectious Diseases Department CHU Yalgado Ouédraogo, Ouagadougou, in order to describe its epidemiological, clinical, and evolutive characteristics. Our study included young females who had an onset age of between 35 years and 45 years, residing in the city of Ouagadougou...
2016: Pan African Medical Journal
H M Faddy, J J Fryk, D Watterson, P R Young, N Modhiran, D A Muller, S D Keil, R P Goodrich, D C Marks
BACKGROUND: Dengue viruses (DENV 1-4) are emerging across the world, and these viruses pose a risk to transfusion safety. Pathogen inactivation may be an alternative approach for managing the risk of DENV transfusion transmission. This study aimed to investigate the ability of riboflavin and UV light to inactivate DENV 1-4 in platelet concentrates. MATERIALS AND METHODS: DENV 1-4 were spiked into buffy coat-derived platelet concentrates in additive solution (SSP+) before being treated with riboflavin and UV light...
October 2016: Vox Sanguinis
Tau-Hong Lee, Joshua G X Wong, Yee-Sin Leo, Tun-Linn Thein, Ee-Ling Ng, Linda K Lee, David C Lye
BACKGROUND: Thrombocytopenia is a hallmark of dengue infection, and bleeding is a dreaded complication of dengue fever. Prophylactic platelet transfusion has been used to prevent bleeding in the management of dengue fever, although the evidence for its benefit is lacking. In adult dengue patients with platelet count <20,000/mm3 without bleeding, we aimed to assess if prophylactic platelet transfusion was effective in reducing clinical bleeding and other outcomes. METHOD: We conducted a retrospective non-randomised observational study of dengue patients with platelet count < 20,000/mm3 without bleeding (except petechiae) admitted to Tan Tock Seng Hospital from January 2005 to December 2008...
March 2016: PLoS Neglected Tropical Diseases
Helen M Faddy, Jesse J Fryk, Natalie A Prow, Daniel Watterson, Paul R Young, Roy A Hall, Frank Tolksdorf, Chryslain Sumian, Ute Gravemann, Axel Seltsam, Denese C Marks
BACKGROUND: Arboviruses, including dengue (DENV 1-4), chikungunya (CHIKV), and Ross River (RRV), are emerging viruses that are a risk for transfusion safety globally. An approach for managing this risk is pathogen inactivation, such as the THERAFLEX UV-Platelets system. We investigated the ability of this system to inactivate the above mentioned arboviruses. STUDY DESIGN AND METHODS: DENV 1-4, CHIKV, or RRV were spiked into buffy coat (BC)-derived platelet (PLT) concentrates in additive solution and treated with the THERAFLEX UV-Platelets system at the following doses: 0...
June 2016: Transfusion
Limei Tan, Junping Wang, Fansen Zeng, Yong Zhang, Chunxiao Fang, Chuan Nie, Yi Xu, Jie Yang
OBJECTIVE: To explore the clinical manifestations and laboratory examination characteristics of neonatal dengue fever. METHOD: A retrospective analysis of 12 cases of neonatal dengue fever treated in the Guangdong Women and Children's Hospital and Guangzhou Women and Children's Medical Center was conducted, and related literature was reviewed. RESULT: Twelve cases of neonatal dengue fever included 9 males and 3 females; their age was 30 min after birth to 29 d, the age of onset was 30 min-24 d...
December 2015: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Ramakrishna Pai Jakribettu, Rekha Boloor, Andrew Thaliath, Sharanya Yesudasan George, Thomas George, Manoj Ponadka Rai, Umran Rafique Sheikh, Kadke Shreedhara Avabratha, Manjeshwar Shrinath Baliga
Dengue is one of the arthropod-borne (arbo) viral diseases transmitted by female mosquito Aedes aegypti. Dengue fever has a wide spectrum of clinical presentation ranging from flu-like illness to severe complicated stage of dengue hemorrhagic fever leading to mortality. This was a retrospective study conducted in a tertiary care hospital in Coastal Karnataka, South India, to know the correlation between the clinical presentation and haematological parameters in the paediatric cases presented with dengue symptoms...
2015: Journal of Tropical Medicine
Michael R Sutherland, Ayo Y Simon, Katherine Serrano, Peter Schubert, Jason P Acker, Edward L G Pryzdial
BACKGROUND: Dengue virus (DENV) is a transfusion-transmissible arbovirus that threatens blood donor systems with approximately 200 million high-titer asymptomatic infections occurring annually. Here we investigated the viability of DENV during storage of donor-derived platelet (PLT) and red blood cell (RBC) units. While purified PLTs have been shown to generate viable DENV, RBCs are replication incompetent. Combined with different storage criteria, distinct virus persistence profiles were anticipated in PLT and RBC units...
May 2016: Transfusion
Sriram Pothapregada, Banupriya Kamalakannan, Mahalakshmy Thulasingam
BACKGROUND & OBJECTIVES: The indications for platelet transfusion in dengue fever are clearly defined in World Health Organization (WHO) guidelines (2011) for dengue fever, but physicians face practical difficulty in its implementation in an epidemic setting. On one hand there is an intense social pressure created by the panic-struck parents to transfuse platelets in presence of bleeding and on the other hand there is a need for its judicious use as the requirement is more than its availability...
December 2015: Journal of Vector Borne Diseases
Rahul Chaurasia, Shamsuz Zaman, Kabita Chatterjee, Bankim Das
BACKGROUND: Dengue infection is a major public health problem. During explosive outbreaks, there is sudden surge in demands of platelet products. The present study was carried out in order to review platelet transfusion practices during the epidemic of dengue. METHODS: We retrospectively reviewed the clinical details including the platelet counts and haemorrhagic tendencies of dengue patients as well as the transfusion requirements of diagnosed dengue cases admitted at our centre...
July 2015: Transfusion Medicine and Hemotherapy
Tania Ramírez-Fonseca, Amaury Segarra-Torres, Francisco Jaume-Anselmi, José Ramírez-Rivera
Immune thrombocytopenia (ITP) is a rare autoimmune disorder characterized by low platelet count and skin-mucosal bleeding. In adults it is usually idiopathic and may have a chronic onset, while in children it is usually acute following a viral illness. Dengue has been rarely reported as a cause of ITP. We report a case of a young adult woman that presented with acute ITP following a dengue virus infection.
April 2015: Boletín de la Asociación Médica de Puerto Rico
Sadhana Mangwana
BACKDROUND: Emerging infectious diseases pose threats to the general human population; including recipients of blood transfusions. Dengue is spreading rapidly to new areas and with increasing frequency of major outbreaks. Screening blood for dengue antigens in dengue-endemic countries would be costly and should, therefore, be recommended only after careful assessment of risk for infection and cost. AIM: A prospective study was conducted to establish the magnitude of the threat that dengue poses to blood safety where it is sporadic with seasonal variations, to quantify risk and to assess that whether screening is feasible and cost-effective...
July 2015: Asian Journal of Transfusion Science
Steven Kleinman
PURPOSE OF REVIEW: To review data about transfusion-transmitted infections so as to assess potential safety benefits of applying pathogen inactivation technology to platelets. RECENT FINDINGS: Residual bacterial risk still exists. Multiple arbovirus epidemics continue to occur and challenge blood safety policy makers in nonendemic developed countries. There is new documentation of transfusion transmission of dengue and Ross River viruses, and new or increased concern about chikungunya and Zika viruses...
November 2015: Current Opinion in Hematology
Harshavardhini Palanivel, Shashikala Nair, Anandhalakshmi Subramaniyan, Philip Vivian Joseph Ratnam, Reba Kanungo
BACKGROUND: Outbreaks of dengue infection occur in several parts of India with clockwork precision closely related to changing seasons. Most recent outbreak in Puducherry occurred between October 2012 and January 2013, affected a sizable pediatric population. A prospective study was done to characterize the demographic, diagnostic and clinical profile of pediatric patients in a tertiary care center in Puducherry. MATERIALS AND METHODS: Data of patients serologically positive for either dengue NS1 antigen or anti-dengue IgM antibodies were analyzed...
July 2015: Indian Journal of Pathology & Microbiology
Lucy C S Lum, Sharifah Faridah Syed Omar, Sasheela Sri La Sri Ponnampalavanar, Lian H Tan, Shamala Devi Sekaran, Adeeba Kamarulzaman
INTRODUCTION: The increasing incidence of dengue among adults in Malaysia and other countries has important implications for health services. Before 2004, in order to cope with the surge in adult dengue admissions, each of the six medical wards in a university hospital took turns daily to admit and manage patients with dengue. Despite regular in-house training, the implementation of the WHO 1997 dengue case management guidelines by the multiple medical teams was piecemeal and resulted in high variability of care...
June 2015: PLoS Neglected Tropical Diseases
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