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https://www.readbyqxmd.com/read/29336231/a-new-and-universal-classification-system-of-skin-substitutes-inspired-by-factorial-design
#1
Evan Davison-Kotler, Vaibhav Sharma, Norbert Kang, Elena García-Gareta
The complexity of the dermal layer of skin means that damage to this section can result in permanent impairment of function. Partial or total dermal loss is a feature of deep burns and chronic wounds such as pressure sores or diabetic ulcers. The issues posed by traditional skin grafts have led to substantial research being carried out in the fields of tissue engineering and biomaterials science to develop a vast array of alternative skin substitutes. Given the large number of different materials, manufacturing methods, and techniques for implementation described for artificial skin substitutes, many classification systems have been created to simplify their categorization...
January 16, 2018: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/29335836/adipogenesis-and-lipid-production-in-adipocytes-subjected-to-sustained-tensile-deformations-and-elevated-glucose-concentration-a-living-cell-scale-model-system-of-diabesity
#2
Maayan Lustig, Amit Gefen, Dafna Benayahu
Adipocyte fate commitment is characterized by morphological changes of fibroblastic pre-adipocyte cells, and specifically by accumulation of lipid droplets (LDs) as part of the adipogenesis metabolism. Formation of LDs indicates the production of triglycerides from glucose through an insulin-regulated glucose internalization process. In obesity, adipocytes typically become insulin resistant, and glucose transport into the cells is impaired, resulting in type 2 diabetes. In the present study, we monitored the adipogenesis in 3T3-L1 cultured cells exposed to high (450 mg/dL hyperglycemia) and low (100 mg/dL physiological) glucose concentrations, in a novel cell culture model system of diabesity...
January 15, 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29332423/first-experiences-with-a-wearable-multisensor-in-an-outpatient-glucose-monitoring-study-part-i-the-users-view
#3
Andreas Caduff, Mattia Zanon, Pavel Zakharov, Martin Mueller, Mark Talary, Achim Krebs, Werner A Stahel, Marc Donath
BACKGROUND: Extensive past work showed that noninvasive continuous glucose monitoring with a wearable Multisensor device worn on the upper arm provides useful information about glucose trends to improve diabetes therapy in controlled and semicontrolled conditions. METHODS: To test previous findings also in uncontrolled in-clinic and outpatient conditions, a long-term study has been conducted to collect Multisensor and reference glucose data in a population of 20 type 1 diabetes subjects...
January 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29324755/hiv-1-co-receptor-tropism-and-liver-fibrosis-in-hiv-infected-patients
#4
Annalisa Saracino, Alessandro Cozzi-Lepri, Milensu Shanyinde, Francesca Ceccherini Silberstein, Silvia Nozza, Antonio Di Biagio, Giovanni Cassola, Giuseppe Bruno, Maria Capobianchi, Massimo Puoti, Laura Monno, Antonella d'Arminio Monforte
BACKGROUND: In vitro, gp120 of both X4 and R5 HIV-1 strains activates human hepatic stellate cells, but if it can promote liver fibrosis in vivo is unknown. We aimed to evaluate if patients carrying X4 or R5 strains have a different liver fibrosis (LF) progression over time. METHODS: A total of 1,137 HIV-infected patients in ICONA cohort (21% females, 7% HCV co-infected) with an available determination of HIV-1 co-receptor tropism (CRT), a Fibrosis-4 Index for Liver Fibrosis (FIB-4) <3...
2018: PloS One
https://www.readbyqxmd.com/read/29318732/association-between-fetal-fraction-on-cell-free-dna-testing-and-first-trimester-markers-for-pre-eclampsia
#5
Daniel L Rolnik, Fabricio da Silva Costa, Timothy J Lee, Maximilian Schmid, Andrew C McLennan
AIMS: To evaluate the association of fetal fraction on cell-free DNA (cfDNA) testing with first trimester markers for pre-eclampsia and to investigate a possible association of low fetal fraction with increased risk for pre-eclampsia (PE) and fetal growth restriction (FGR). METHODS: This was a retrospective cohort study including all women with singleton pregnancies who had risk calculation for PE and FGR between 11+0 and 13+6 weeks' gestation and also decided to have cfDNA as a primary or secondary screening test for chromosomal abnormalities at any gestational age in two Fetal Medicine clinics in Sydney and Melbourne, Australia, between March 2013 and May 2017...
January 10, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29318442/an-exudate-detection-method-for-diagnosis-risk-of-diabetic-macular-edema-in-retinal-images-using-feature-based-and-supervised-classification
#6
D Marin, M E Gegundez-Arias, B Ponte, F Alvarez, J Garrido, C Ortega, M J Vasallo, J M Bravo
The present paper aims at presenting the methodology and first results of a detection system of risk of diabetic macular edema (DME) in fundus images. The system is based on the detection of retinal exudates (Ex), whose presence in the image is clinically used for an early diagnosis of the disease. To do so, the system applies digital image processing algorithms to the retinal image in order to obtain a set of candidate regions to be Ex, which are validated by means of feature extraction and supervised classification techniques...
January 10, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29317385/development-and-evaluation-of-a-mobile-personalized-blood-glucose-prediction-system-for-patients-with-gestational-diabetes-mellitus
#7
Evgenii Pustozerov, Polina Popova, Aleksandra Tkachuk, Yana Bolotko, Zafar Yuldashev, Elena Grineva
BACKGROUND: Personalized blood glucose (BG) prediction for diabetes patients is an important goal that is pursued by many researchers worldwide. Despite many proposals, only a few projects are dedicated to the development of complete recommender system infrastructures that incorporate BG prediction algorithms for diabetes patients. The development and implementation of such a system aided by mobile technology is of particular interest to patients with gestational diabetes mellitus (GDM), especially considering the significant importance of quickly achieving adequate BG control for these patients in a short period (ie, during pregnancy) and a typically higher acceptance rate for mobile health (mHealth) solutions for short- to midterm usage...
January 9, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29311586/the-corneal-subbasal-nerve-plexus-and-thickness-of-the-retinal-layers-in-pediatric-type-1-diabetes-and-matched-controls
#8
Aline Götze, Sophie von Keyserlingk, Sabine Peschel, Ulrike Jacoby, Corinna Schreiver, Bernd Köhler, Stephan Allgeier, Karsten Winter, Martin Röhlig, Anselm Jünemann, Rainer Guthoff, Oliver Stachs, Dagmar-C Fischer
Optical coherence tomography (OCT) of the retina and corneal confocal laser scanning microscopy (CLSM) of the subbasal nerve plexus (SBP) are noninvasive techniques for quantification of the ocular neurodegenerative changes in individuals with type 1 diabetes mellitus (T1DM). In adult T1DM patients these changes are hardly related to T1DM only. Instead, ageing and/or lifestyle associated comorbidities have to be considered as putative confounding variables. Therefore, we investigated pediatric T1DM patients (n = 28; 14...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29306956/applying-a-big-data-literature-system-to-recommend-antihypertensive-drugs-for-hypertension-patients-with-diabetes-mellitus
#9
Jing-Xian Shu, Ying Li, Ting He, Ling Chen, Xue Li, Lin-Lin Zou, Lu Yin, Xiao-Hui Li, An-Li Wang, Xing Liu, Hong Yuan
BACKGROUND The explosive increase in medical literature has changed therapeutic strategies, but it is challenging for physicians to keep up-to-date on the medical literature. Scientific literature data mining on a large-scale of can be used to refresh physician knowledge and better improve the quality of disease treatment. MATERIAL AND METHODS This paper reports on a reformulated version of a data mining method called MedRank, which is a network-based algorithm that ranks therapy for a target disease based on the MEDLINE literature database...
January 7, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29302534/exercise-in-patients-with-type-2-diabetes-facilitators-and-barriers-a-qualitative-study
#10
T S Advika, Jyothi Idiculla, S Jaya Kumari
Introduction: Diabetes is a major noncommunicable disease affecting more than 65 million Indians. Although treatment algorithms suggest lifestyle measures (diet and exercise) along with medications data regarding adherence to exercise as well as facilitators and barriers to the practice of physical activity in such patients are limited. Hence, this qualitative study was conducted. Objectives: The objective of this study is to describe the factors which (1) Facilitated and (2) hindered the practice of regular exercise in patients with Type 2 diabetes...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29300116/comparative-analysis-of-classification-based-algorithms-for-diabetes-diagnosis-using-iris-images
#11
Piyush Samant, Ravinder Agarwal
Photo-diagnosis is always an intriguing area for the researchers, with the advancement of image processing and computer machine vision techniques it have become more reliable and popular in recent years. The objective of this paper is to study the change in the features of iris, particularly irregularities in the pigmentation of certain areas of the iris with respect to diabetic health of an individual. Apart from the point that iris recognition concentrates on the overall structure of the iris, diagnostic techniques emphasises the local variations in the particular area of iris...
January 4, 2018: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/29297448/score-for-pulmonary-tuberculosis-in-patients-with-clinical-presumption-of-tuberculosis-in-a-low-prevalence-area
#12
T Delory, H Ferrand, N Grall, E Casalino, M Lafarge, B Melot, D Hajage, C Charpentier, M Aubier, F Tubach, E Bouvet, N Gault, Y Yazdanpanah
OBJECTIVES: To develop a diagnostic predictive model for the identification of patients with presumptive pulmonary tuberculosis (PTB) at high risk for active disease and those requiring nucleic acid amplification (NAAT) testing and/or preventive respiratory isolation in low-incidence, high-income countries. DESIGN: A 1:1 case-control study was conducted in consecutive immunocompetent patients with presumed PTB hospitalised between 2009 and 2012 in Paris, France...
December 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297288/deep-learning-architectures-for-multi-label-classification-of-intelligent-health-risk-prediction
#13
Andrew Maxwell, Runzhi Li, Bei Yang, Heng Weng, Aihua Ou, Huixiao Hong, Zhaoxian Zhou, Ping Gong, Chaoyang Zhang
BACKGROUND: Multi-label classification of data remains to be a challenging problem. Because of the complexity of the data, it is sometimes difficult to infer information about classes that are not mutually exclusive. For medical data, patients could have symptoms of multiple different diseases at the same time and it is important to develop tools that help to identify problems early. Intelligent health risk prediction models built with deep learning architectures offer a powerful tool for physicians to identify patterns in patient data that indicate risks associated with certain types of chronic diseases...
December 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29297197/socioeconomic-status-and-cardiovascular-risk-score
#14
Ewa Podolecka, Agnieszka Doryńska, Paweł Nadrowski, Michał Skrzypek, Magdalena Kwaśniewska, Wojciech Drygas, Andrzej Pająk, Krystyna Kozakiewicz
BACKGROUND: Cardiovascular diseases are one of the most frequent causes of morbidity and death both in men and women. Well known is the influence of such factors as: hypertension, hypercholesterolemia, tobacco smoking, obesity, diabetes, age and sex on the occurrence and progression of atherosclerosis. Apart from the typical risk factors of cardiovascular diseases, there is also a significant association between the incidence of those diseases and the socioeconomic status (SES). AIM: The aim of this study was to establish the correlation between the socioeconomic status and the cardiovascular disease risk assessed according to the SCORE algorithm...
January 3, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29296475/automated-detection-of-photoreceptor-disruption-in-mild-diabetic-retinopathy-on-volumetric-optical-coherence-tomography
#15
Zhuo Wang, Acner Camino, Miao Zhang, Jie Wang, Thomas S Hwang, David J Wilson, David Huang, Dengwang Li, Yali Jia
Diabetic retinopathy is a pathology where microvascular circulation abnormalities ultimately result in photoreceptor disruption and, consequently, permanent loss of vision. Here, we developed a method that automatically detects photoreceptor disruption in mild diabetic retinopathy by mapping ellipsoid zone reflectance abnormalities from en face optical coherence tomography images. The algorithm uses a fuzzy c-means scheme with a redefined membership function to assign a defect severity level on each pixel and generate a probability map of defect category affiliation...
December 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29286091/identifying-heterogeneous-subtypes-of-gastric-cancer-and-subtype%C3%A2-specific-subpaths-of-microrna%C3%A2-target-pathways
#16
Yuanhang Li, Weijun Bai, Xu Zhang
The present study aimed to classify gastric cancer (GC) into subtypes and to screen the subtype‑specific genes, their targeted microRNAs (miRNAs) and enriched pathways to explore the putative mechanism of each GC subtypes. The GSE13861 data set was downloaded from the Gene Expression Omnibus and used to screen differential expression genes (DEGs) in GC samples based on the detection of imbalanced differential signal algorithm. The specific genes in each subtype were identified with the cut‑off criterion of U>0...
December 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29281690/sensitivity-and-specificity-of-automated-analysis-of-single-field-non-mydriatic-fundus-photographs-by-bosch-dr-algorithm-comparison-with-mydriatic-fundus-photography-etdrs-for-screening-in-undiagnosed-diabetic-retinopathy
#17
Pritam Bawankar, Nita Shanbhag, S Smitha K, Bodhraj Dhawan, Aratee Palsule, Devesh Kumar, Shailja Chandel, Suneet Sood
Diabetic retinopathy (DR) is a leading cause of blindness among working-age adults. Early diagnosis through effective screening programs is likely to improve vision outcomes. The ETDRS seven-standard-field 35-mm stereoscopic color retinal imaging (ETDRS) of the dilated eye is elaborate and requires mydriasis, and is unsuitable for screening. We evaluated an image analysis application for the automated diagnosis of DR from non-mydriatic single-field images. Patients suffering from diabetes for at least 5 years were included if they were 18 years or older...
2017: PloS One
https://www.readbyqxmd.com/read/29280295/emerging-roles-of-rna-binding-proteins-in-diabetes-and-their-therapeutic-potential-in-diabetic-complications
#18
REVIEW
Curtis A Nutter, Muge N Kuyumcu-Martinez
Diabetes is a debilitating health care problem affecting 422 million people around the world. Diabetic patients suffer from multisystemic complications that can cause mortality and morbidity. Recent advancements in high-throughput next-generation RNA-sequencing and computational algorithms led to the discovery of aberrant posttranscriptional gene regulatory programs in diabetes. However, very little is known about how these regulatory programs are mis-regulated in diabetes. RNA-binding proteins (RBPs) are important regulators of posttranscriptional RNA networks, which are also dysregulated in diabetes...
December 27, 2017: Wiley Interdisciplinary Reviews. RNA
https://www.readbyqxmd.com/read/29280255/incidence-and-prevalence-trends-of-youth-onset-type-2-diabetes-in-a-cohort-of-canadian-youth-2002-2013
#19
Shazhan Amed, Nazrul Islam, Jenny Sutherland, Kim Reimer
OBJECTIVE: Youth-onset type 2 diabetes is an emerging disease. We estimated incidence and prevalence trends of youth-onset type 2 diabetes between 2002 and 2013 in the Canadian province of British Columbia. METHODS: This population-based cohort study used a validated diabetes case-finding definition and algorithm to differentiate type 2 from type 1 diabetes to identify youth <20 years with type 2 diabetes within linked population-based administrative data. Age-standardized incidence and prevalence were calculated...
December 27, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29279690/immune-checkpoint-inhibitor-associated-type-1-diabetes-mellitus-case-series-review-of-the-literature-and-optimal-management
#20
Jonathan Kapke, Zachary Shaheen, Deepak Kilari, Paul Knudson, Stuart Wong
With the introduction of immune checkpoint inhibitors into clinical practice, various autoimmune toxicities have been described. Antibodies targeting the receptor:ligand pairing of programmed death receptor-1 (PD-1) and its cognate ligand programmed death-ligand 1 (PD-L1) in rare reports have been associated with autoimmune diabetes mellitus. We report 2 cases of rapid-onset, insulin-dependent, type 1 diabetes mellitus in the setting of administration of nivolumab, a fully human monoclonal antibody to PD-1, and atezolizumab, a humanized monoclonal antibody to PD-L1...
September 2017: Case Reports in Oncology
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