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JOURNAL ARTICLE
Leo Verhagen Metman, Konstantin V Slavin, Joshua M Rosenow, Jerrold L Vitek, Pepijn van den Munckhof
No abstract text is available yet for this article.
December 2021: Movement Disorders: Official Journal of the Movement Disorder Society
#22
JOURNAL ARTICLE
Takehiro Yako, Kazuo Kitazawa, Shigeaki Kobayashi, Shoji Yomo, Hiromasa Sato, Luke A Johnson, Jerrold L Vitek, Takao Hashimoto
BACKGROUND: Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) has been reported to improve gait disturbances in Parkinson's disease (PD); however, there are controversies on the radiological and electrophysiological techniques for intraoperative and postoperative confirmation of the target and determination of optimal stimulation parameters. OBJECTIVES: We investigated the correlation between the location of the estimated PPN (ePPN) and neuronal activity collected during intraoperative electrophysiological mapping to evaluate the role of microelectrode recording (MER) in identifying the effective stimulation site in two PD patients...
August 2022: Neuromodulation: Journal of the International Neuromodulation Society
#23
JOURNAL ARTICLE
AnneMarie K Brinda, Alex M Doyle, Madeline Blumenfeld, Jordan Krieg, Joseph S R Alisch, Chelsea Spencer, Emily Lecy, Lucius K Wilmerding, Adele DeNicola, Luke A Johnson, Jerrold L Vitek, Matthew D Johnson
Objective. The electrode-tissue interface surrounding a deep brain stimulation (DBS) lead is known to be highly dynamic following implantation, which may have implications on the interpretation of intraoperatively recorded local field potentials (LFPs). We characterized beta-band LFP dynamics following implantation of a directional DBS lead in the sensorimotor subthalamic nucleus (STN), which is a primary target for treating Parkinson's disease. Approach. Directional STN-DBS leads were implanted in four healthy, non-human primates...
May 13, 2021: Journal of Neural Engineering
#24
JOURNAL ARTICLE
Luke A Johnson, Joshua E Aman, Ying Yu, David Escobar Sanabria, Jing Wang, Meghan Hill, Rajiv Dharnipragada, Remi Patriat, Mark Fiecas, Laura Li, Lauren E Schrock, Scott E Cooper, Matthew D Johnson, Michael C Park, Noam Harel, Jerrold L Vitek
BACKGROUND: Abnormal oscillatory neural activity in the beta-frequency band (13-35 Hz) is thought to play a role in Parkinson's disease (PD); however, increasing evidence points to alterations in high-frequency ranges (>100 Hz) also having pathophysiological relevance. OBJECTIVES: Studies have found that power in subthalamic nucleus (STN) high-frequency oscillations is increased with dopaminergic medication and during voluntary movements, implicating these brain rhythms in normal basal ganglia function...
April 13, 2021: Movement Disorders: Official Journal of the Movement Disorder Society
#25
JOURNAL ARTICLE
Oren Solomon, Tara Palnitkar, Re'mi Patriat, Henry Braun, Joshua Aman, Michael C Park, Jerrold Vitek, Guillermo Sapiro, Noam Harel
Deep brain stimulation (DBS) surgery has been shown to dramatically improve the quality of life for patients with various motor dysfunctions, such as those afflicted with Parkinson's disease (PD), dystonia, and essential tremor (ET), by relieving motor symptoms associated with such pathologies. The success of DBS procedures is directly related to the proper placement of the electrodes, which requires the ability to accurately detect and identify relevant target structures within the subcortical basal ganglia region...
March 18, 2021: Human Brain Mapping
#26
JOURNAL ARTICLE
Amanda R Merner, Thomas Frazier, Paul J Ford, Scott E Cooper, Andre Machado, Brittany Lapin, Jerrold Vitek, Cynthia S Kubu
Objective : To examine changes in patients' desired control of the deep brain stimulator (DBS) and perception of global life control throughout DBS. Methods : A consecutive cohort of 52 patients with Parkinson's disease (PD) was recruited to participate in a prospective longitudinal study over three assessment points (pre-surgery, post-surgery months 3 and 6). Semi-structured interviews assessing participants' desire for stimulation control and perception of global control were conducted at all three points...
2021: Frontiers in Human Neuroscience
#27
Lauren E Schrock, Remi Patriat, Mojgan Goftari, Jiwon Kim, Matthew D Johnson, Noam Harel, Jerrold L Vitek
Subthalamic nucleus (STN) deep brain stimulation (DBS) is an established therapy for Parkinson's disease motor symptoms. The ideal site for implantation within STN, however, remains controversial. While many argue that placement of a DBS lead within the sensorimotor territory of the STN yields better motor outcomes, others report similar effects with leads placed in the associative or motor territory of the STN, while still others assert that placing a DBS lead "anywhere within a 6-mm-diameter cylinder centered at the presumed middle of the STN (based on stereotactic atlas coordinates) produces similar clinical efficacy...
2021: Frontiers in Human Neuroscience
#28
JOURNAL ARTICLE
Ying Yu, David Escobar Sanabria, Jing Wang, Claudia M Hendrix, Jianyu Zhang, Shane D Nebeck, Alexia M Amundson, Zachary B Busby, Devyn L Bauer, Matthew D Johnson, Luke A Johnson, Jerrold L Vitek
Elevated synchronized oscillatory activity in the beta band has been hypothesized to be a pathophysiological marker of Parkinson's disease (PD). Recent studies have suggested that parkinsonism is closely associated with increased amplitude and duration of beta burst activity in the subthalamic nucleus (STN). How beta burst dynamics are altered from the normal to parkinsonian state across the basal ganglia-thalamocortical (BGTC) motor network, however, remains unclear. In this study we simultaneously recorded local field potential (LFP) activity from the STN, internal segment of the globus pallidus (GPi) and primary motor cortex (M1) in three female rhesus macaques and characterized how beta burst activity changed as the animals transitioned from normal to progressively more severe parkinsonian states...
January 22, 2021: Journal of Neuroscience
#29
JOURNAL ARTICLE
Chiahao Lu, Sommer L Amundsen-Huffmaster, Kenneth H Louie, Robert Lowe, Reme Abulu, Robert A McGovern, Jerrold L Vitek, Colum D MacKinnon, Scott E Cooper
BACKGROUND: Assessing postural stability in Parkinson's disease (PD) often relies on measuring the stepping response to an imposed postural perturbation. The standard clinical technique relies on a brisk backwards pull at the shoulders by the examiner and judgement by a trained rater. In research settings, various quantitative measures and perturbation directions have been tested, but it is unclear which metrics and perturbation direction differ most between people with PD and controls...
December 23, 2020: Gait & Posture
#30
JOURNAL ARTICLE
David Escobar Sanabria, Luke A Johnson, Ying Yu, Zachary Busby, Shane Nebeck, Jianyu Zhang, Noam Harel, Matthew D Johnson, Gregory F Molnar, Jerrold L Vitek
BACKGROUND: Approaches to predictably control neural oscillations are needed to understand their causal role in brain function in healthy or diseased states and to advance the development of neuromodulation therapies. In this study, we present a closed-loop neural control and optimization framework to actively suppress or amplify low-frequency neural oscillations observed in local field potentials in real-time by using electrical stimulation. OBJECTIVE: /Hypothesis: The rationale behind this control approach and our working hypothesis is that neural oscillatory activity evoked by electrical pulses can suppress or amplify spontaneous oscillations via destructive or constructive interference when stimulation pulses are continuously delivered with appropriate amplitudes and at precise phases of these oscillations in a closed-loop scheme...
October 6, 2020: Brain Stimulation
#31
JOURNAL ARTICLE
Luke Johnson, Ivan Alekseichuk, Jordan Krieg, Alex Doyle, Ying Yu, Jerrold Vitek, Matthew Johnson, Alexander Opitz
Weak extracellular electric fields can influence spike timing in neural networks. Approaches to noninvasively impose these fields on the brain have high therapeutic potential in neurology and psychiatry. Transcranial alternating current stimulation (TACS) is hypothesized to affect spike timing and cause neural entrainment. However, the conditions under which these effects occur in vivo are unknown. Here, we recorded single-unit activity in the neocortex in awake nonhuman primates during TACS and found dose-dependent neural entrainment to the stimulation waveform...
September 2020: Science Advances
#32
Tseganesh Orcutt, Jerrold Vitek, Rémi Patriat, Noam Harel, Joseph Matsumoto
No abstract text is available yet for this article.
August 2020: Movement Disorders Clinical Practice
#33
RANDOMIZED CONTROLLED TRIAL
Jerrold L Vitek, Roshini Jain, Lilly Chen, Alexander I Tröster, Lauren E Schrock, Paul A House, Monique L Giroux, Adam O Hebb, Sierra M Farris, Donald M Whiting, Timothy A Leichliter, Jill L Ostrem, Marta San Luciano, Nicholas Galifianakis, Leo Verhagen Metman, Sepehr Sani, Jessica A Karl, Mustafa S Siddiqui, Stephen B Tatter, Ihtsham Ul Haq, Andre G Machado, Michal Gostkowski, Michele Tagliati, Adam N Mamelak, Michael S Okun, Kelly D Foote, Guillermo Moguel-Cobos, Francisco A Ponce, Rajesh Pahwa, Jules M Nazzaro, Cathrin M Buetefisch, Robert E Gross, Corneliu C Luca, Jonathan R Jagid, Gonzalo J Revuelta, Istvan Takacs, Michael H Pourfar, Alon Y Mogilner, Andrew P Duker, George T Mandybur, Joshua M Rosenow, Scott E Cooper, Michael C Park, Suketu M Khandhar, Mark Sedrak, Fenna T Phibbs, Julie G Pilitsis, Ryan J Uitti, Philip A Starr
BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus is an established therapeutic option for managing motor symptoms of Parkinson's disease. We conducted a double-blind, sham-controlled, randomised controlled trial to assess subthalamic nucleus DBS, with a novel multiple independent contact current-controlled (MICC) device, in patients with Parkinson's disease. METHODS: This trial took place at 23 implanting centres in the USA. Key inclusion criteria were age between 22 and 75 years, a diagnosis of idiopathic Parkinson's disease with over 5 years of motor symptoms, and stable use of anti-parkinsonian medications for 28 days before consent...
June 2020: Lancet Neurology
#34
REVIEW
Codrin Lungu, Laurie Ozelius, David Standaert, Mark Hallett, Beth-Anne Sieber, Christine Swanson-Fisher, Brian D Berman, Nicole Calakos, Jennifer C Moore, Joel S Perlmutter, Sarah E Pirio Richardson, Rachel Saunders-Pullman, Laura Scheinfeldt, Nutan Sharma, Roy Sillitoe, Kristina Simonyan, Philip A Starr, Anna Taylor, Jerrold Vitek
OBJECTIVE: Dystonia is a complex movement disorder. Research progress has been difficult, particularly in developing widely effective therapies. This is a review of the current state of knowledge, research gaps, and proposed research priorities. METHODS: The NIH convened leaders in the field for a 2-day workshop. The participants addressed the natural history of the disease, the underlying etiology, the pathophysiology, relevant research technologies, research resources, and therapeutic approaches and attempted to prioritize dystonia research recommendations...
March 24, 2020: Neurology
#35
JOURNAL ARTICLE
Joshua E Aman, Luke A Johnson, David Escobar Sanabria, Jing Wang, Remi Patriat, Meghan Hill, Ethan Marshall, Colum D MacKinnon, Scott E Cooper, Lauren E Schrock, Michael C Park, Noam Harel, Jerrold L Vitek
The goal of this study was to characterize the spectral characteristics and spatial topography of local field potential (LFP) activity in the internal segment of the globus pallidus (GPi) in patients with Parkinson's disease utilizing directional (segmented) deep brain stimulation (dDBS) leads. Data were collected from externalized dDBS leads of three patients with idiopathic Parkinson's disease after overnight withdrawal of parkinsonian medication at rest and during a cued reach-to-target task. Oscillatory activity across lead contacts/segments was examined in the context of lead locations and contact orientations determined using co-registered preoperative 7 Tesla (T) MRI and postoperative CT scans...
February 20, 2020: Neurobiology of Disease
#36
JOURNAL ARTICLE
Luke A Johnson, Jing Wang, Shane D Nebeck, Jianyu Zhang, Matthew D Johnson, Jerrold L Vitek
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) is an effective treatment for parkinsonian motor signs. Though its therapeutic mechanisms remain unclear, it has been suggested that antidromic activation of the primary motor cortex (M1) plays a significant role in mediating its therapeutic effects. This study tested the hypothesis that antidromic activation of M1 is a prominent feature underlying the therapeutic effect of STN and GPi DBS. Single-unit activity in M1 was recorded using high-density microelectrode arrays in two parkinsonian non-human primates each implanted with DBS leads targeting the STN and GPi...
February 3, 2020: Journal of Neuroscience
#37
JOURNAL ARTICLE
Jerrold L Vitek, Luke A Johnson
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder affecting over 10 million people worldwide. In the 1930s and 1940s there was little understanding regarding what caused PD or how to treat it. In a desperate attempt to improve patients' lives different regions of the neuraxis were ablated. Morbidity and mortality were common, but some patients' motor signs improved with lesions involving the basal ganglia or thalamus. With the discovery of l-dopa the advent of medical therapy began and surgical approaches became less frequent...
December 23, 2019: Proceedings of the National Academy of Sciences of the United States of America
#38
JOURNAL ARTICLE
Adolfo Ramirez-Zamora, James Giordano, Edward S Boyden, Viviana Gradinaru, Aysegul Gunduz, Philip A Starr, Sameer A Sheth, Cameron C McIntyre, Michael D Fox, Jerrold Vitek, Vinata Vedam-Mai, Umer Akbar, Leonardo Almeida, Helen M Bronte-Stewart, Helen S Mayberg, Nader Pouratian, Aryn H Gittis, Annabelle C Singer, Meaghan C Creed, Gabriel Lazaro-Munoz, Mark Richardson, Marvin A Rossi, Leopoldo Cendejas-Zaragoza, Pierre-Francois D'Haese, Winston Chiong, Ro'ee Gilron, Howard Chizeck, Andrew Ko, Kenneth B Baker, Joost Wagenaar, Noam Harel, Wissam Deeb, Kelly D Foote, Michael S Okun
The annual deep brain stimulation (DBS) Think Tank aims to create an opportunity for a multidisciplinary discussion in the field of neuromodulation to examine developments, opportunities and challenges in the field. The proceedings of the Sixth Annual Think Tank recapitulate progress in applications of neurotechnology, neurophysiology, and emerging techniques for the treatment of a range of psychiatric and neurological conditions including Parkinson's disease, essential tremor, Tourette syndrome, epilepsy, cognitive disorders, and addiction...
2019: Frontiers in Neuroscience
#39
JOURNAL ARTICLE
Yigitcan Eryaman, Naoharu Kobayashi, Sean Moen, Joshua Aman, Andrea Grant, J Thomas Vaughan, Gregory Molnar, Michael C Park, Jerrold Vitek, Gregor Adriany, Kamil Ugurbil, Noam Harel
The purpose of this work is to present a new method that can be used to estimate and mitigate RF induced currents on Deep Brain Stimulation (DBS) leads. Here, we demonstrate the effect of RF induced current mitigation on both RF heating and image quality for a variety of brain MRI sequences at 3 T. We acquired pre-scan images around a DBS lead (in-situ and ex-vivo) using conventional Gradient Echo Sequence (GRE) accelerated by parallel imaging (i.e GRAPPA) and quantified the magnitude and phase of RF induced current using the relative location of the B1+ null with respect to the lead position...
January 1, 2019: NeuroImage
#40
JOURNAL ARTICLE
Edgar Peña, Simeng Zhang, Remi Patriat, Joshua E Aman, Jerrold L Vitek, Noam Harel, Matthew D Johnson
OBJECTIVE: The effectiveness of deep brain stimulation (DBS) therapy strongly depends on precise surgical targeting of intracranial leads and on clinical optimization of stimulation settings. Recent advances in surgical targeting, multi-electrode designs, and multi-channel independent current-controlled stimulation are poised to enable finer control in modulating pathways within the brain. However, the large stimulation parameter space enabled by these technologies also poses significant challenges for efficiently identifying the most therapeutic DBS setting for a given patient...
December 2018: Journal of Neural Engineering
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