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JOURNAL ARTICLE
Takehiro Yako, Kazuo Kitazawa, Shigeaki Kobayashi, Shoji Yomo, Hiromasa Sato, Luke A Johnson, Jerrold L Vitek, Takao Hashimoto
BACKGROUND: Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) has been reported to improve gait disturbances in Parkinson's disease (PD); however, there are controversies on the radiological and electrophysiological techniques for intraoperative and postoperative confirmation of the target and determination of optimal stimulation parameters. OBJECTIVES: We investigated the correlation between the location of the estimated PPN (ePPN) and neuronal activity collected during intraoperative electrophysiological mapping to evaluate the role of microelectrode recording (MER) in identifying the effective stimulation site in two PD patients...
August 2022: Neuromodulation: Journal of the International Neuromodulation Society
#22
JOURNAL ARTICLE
AnneMarie K Brinda, Alex M Doyle, Madeline Blumenfeld, Jordan Krieg, Joseph S R Alisch, Chelsea Spencer, Emily Lecy, Lucius K Wilmerding, Adele DeNicola, Luke A Johnson, Jerrold L Vitek, Matthew D Johnson
Objective. The electrode-tissue interface surrounding a deep brain stimulation (DBS) lead is known to be highly dynamic following implantation, which may have implications on the interpretation of intraoperatively recorded local field potentials (LFPs). We characterized beta-band LFP dynamics following implantation of a directional DBS lead in the sensorimotor subthalamic nucleus (STN), which is a primary target for treating Parkinson's disease. Approach. Directional STN-DBS leads were implanted in four healthy, non-human primates...
May 13, 2021: Journal of Neural Engineering
#23
JOURNAL ARTICLE
Luke A Johnson, Joshua E Aman, Ying Yu, David Escobar Sanabria, Jing Wang, Meghan Hill, Rajiv Dharnipragada, Remi Patriat, Mark Fiecas, Laura Li, Lauren E Schrock, Scott E Cooper, Matthew D Johnson, Michael C Park, Noam Harel, Jerrold L Vitek
BACKGROUND: Abnormal oscillatory neural activity in the beta-frequency band (13-35 Hz) is thought to play a role in Parkinson's disease (PD); however, increasing evidence points to alterations in high-frequency ranges (>100 Hz) also having pathophysiological relevance. OBJECTIVES: Studies have found that power in subthalamic nucleus (STN) high-frequency oscillations is increased with dopaminergic medication and during voluntary movements, implicating these brain rhythms in normal basal ganglia function...
April 13, 2021: Movement Disorders: Official Journal of the Movement Disorder Society
#24
Lauren E Schrock, Remi Patriat, Mojgan Goftari, Jiwon Kim, Matthew D Johnson, Noam Harel, Jerrold L Vitek
Subthalamic nucleus (STN) deep brain stimulation (DBS) is an established therapy for Parkinson's disease motor symptoms. The ideal site for implantation within STN, however, remains controversial. While many argue that placement of a DBS lead within the sensorimotor territory of the STN yields better motor outcomes, others report similar effects with leads placed in the associative or motor territory of the STN, while still others assert that placing a DBS lead "anywhere within a 6-mm-diameter cylinder centered at the presumed middle of the STN (based on stereotactic atlas coordinates) produces similar clinical efficacy...
2021: Frontiers in Human Neuroscience
#25
JOURNAL ARTICLE
Ying Yu, David Escobar Sanabria, Jing Wang, Claudia M Hendrix, Jianyu Zhang, Shane D Nebeck, Alexia M Amundson, Zachary B Busby, Devyn L Bauer, Matthew D Johnson, Luke A Johnson, Jerrold L Vitek
Elevated synchronized oscillatory activity in the beta band has been hypothesized to be a pathophysiological marker of Parkinson's disease (PD). Recent studies have suggested that parkinsonism is closely associated with increased amplitude and duration of beta burst activity in the subthalamic nucleus (STN). How beta burst dynamics are altered from the normal to parkinsonian state across the basal ganglia-thalamocortical (BGTC) motor network, however, remains unclear. In this study we simultaneously recorded local field potential (LFP) activity from the STN, internal segment of the globus pallidus (GPi) and primary motor cortex (M1) in three female rhesus macaques and characterized how beta burst activity changed as the animals transitioned from normal to progressively more severe parkinsonian states...
January 22, 2021: Journal of Neuroscience
#26
JOURNAL ARTICLE
Chiahao Lu, Sommer L Amundsen-Huffmaster, Kenneth H Louie, Robert Lowe, Reme Abulu, Robert A McGovern, Jerrold L Vitek, Colum D MacKinnon, Scott E Cooper
BACKGROUND: Assessing postural stability in Parkinson's disease (PD) often relies on measuring the stepping response to an imposed postural perturbation. The standard clinical technique relies on a brisk backwards pull at the shoulders by the examiner and judgement by a trained rater. In research settings, various quantitative measures and perturbation directions have been tested, but it is unclear which metrics and perturbation direction differ most between people with PD and controls...
December 23, 2020: Gait & Posture
#27
JOURNAL ARTICLE
David Escobar Sanabria, Luke A Johnson, Ying Yu, Zachary Busby, Shane Nebeck, Jianyu Zhang, Noam Harel, Matthew D Johnson, Gregory F Molnar, Jerrold L Vitek
BACKGROUND: Approaches to predictably control neural oscillations are needed to understand their causal role in brain function in healthy or diseased states and to advance the development of neuromodulation therapies. In this study, we present a closed-loop neural control and optimization framework to actively suppress or amplify low-frequency neural oscillations observed in local field potentials in real-time by using electrical stimulation. OBJECTIVE: /Hypothesis: The rationale behind this control approach and our working hypothesis is that neural oscillatory activity evoked by electrical pulses can suppress or amplify spontaneous oscillations via destructive or constructive interference when stimulation pulses are continuously delivered with appropriate amplitudes and at precise phases of these oscillations in a closed-loop scheme...
October 6, 2020: Brain Stimulation
#28
RANDOMIZED CONTROLLED TRIAL
Jerrold L Vitek, Roshini Jain, Lilly Chen, Alexander I Tröster, Lauren E Schrock, Paul A House, Monique L Giroux, Adam O Hebb, Sierra M Farris, Donald M Whiting, Timothy A Leichliter, Jill L Ostrem, Marta San Luciano, Nicholas Galifianakis, Leo Verhagen Metman, Sepehr Sani, Jessica A Karl, Mustafa S Siddiqui, Stephen B Tatter, Ihtsham Ul Haq, Andre G Machado, Michal Gostkowski, Michele Tagliati, Adam N Mamelak, Michael S Okun, Kelly D Foote, Guillermo Moguel-Cobos, Francisco A Ponce, Rajesh Pahwa, Jules M Nazzaro, Cathrin M Buetefisch, Robert E Gross, Corneliu C Luca, Jonathan R Jagid, Gonzalo J Revuelta, Istvan Takacs, Michael H Pourfar, Alon Y Mogilner, Andrew P Duker, George T Mandybur, Joshua M Rosenow, Scott E Cooper, Michael C Park, Suketu M Khandhar, Mark Sedrak, Fenna T Phibbs, Julie G Pilitsis, Ryan J Uitti, Philip A Starr
BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus is an established therapeutic option for managing motor symptoms of Parkinson's disease. We conducted a double-blind, sham-controlled, randomised controlled trial to assess subthalamic nucleus DBS, with a novel multiple independent contact current-controlled (MICC) device, in patients with Parkinson's disease. METHODS: This trial took place at 23 implanting centres in the USA. Key inclusion criteria were age between 22 and 75 years, a diagnosis of idiopathic Parkinson's disease with over 5 years of motor symptoms, and stable use of anti-parkinsonian medications for 28 days before consent...
June 2020: Lancet Neurology
#29
JOURNAL ARTICLE
Joshua E Aman, Luke A Johnson, David Escobar Sanabria, Jing Wang, Remi Patriat, Meghan Hill, Ethan Marshall, Colum D MacKinnon, Scott E Cooper, Lauren E Schrock, Michael C Park, Noam Harel, Jerrold L Vitek
The goal of this study was to characterize the spectral characteristics and spatial topography of local field potential (LFP) activity in the internal segment of the globus pallidus (GPi) in patients with Parkinson's disease utilizing directional (segmented) deep brain stimulation (dDBS) leads. Data were collected from externalized dDBS leads of three patients with idiopathic Parkinson's disease after overnight withdrawal of parkinsonian medication at rest and during a cued reach-to-target task. Oscillatory activity across lead contacts/segments was examined in the context of lead locations and contact orientations determined using co-registered preoperative 7 Tesla (T) MRI and postoperative CT scans...
February 20, 2020: Neurobiology of Disease
#30
JOURNAL ARTICLE
Luke A Johnson, Jing Wang, Shane D Nebeck, Jianyu Zhang, Matthew D Johnson, Jerrold L Vitek
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) is an effective treatment for parkinsonian motor signs. Though its therapeutic mechanisms remain unclear, it has been suggested that antidromic activation of the primary motor cortex (M1) plays a significant role in mediating its therapeutic effects. This study tested the hypothesis that antidromic activation of M1 is a prominent feature underlying the therapeutic effect of STN and GPi DBS. Single-unit activity in M1 was recorded using high-density microelectrode arrays in two parkinsonian non-human primates each implanted with DBS leads targeting the STN and GPi...
February 3, 2020: Journal of Neuroscience
#31
JOURNAL ARTICLE
Jerrold L Vitek, Luke A Johnson
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder affecting over 10 million people worldwide. In the 1930s and 1940s there was little understanding regarding what caused PD or how to treat it. In a desperate attempt to improve patients' lives different regions of the neuraxis were ablated. Morbidity and mortality were common, but some patients' motor signs improved with lesions involving the basal ganglia or thalamus. With the discovery of l-dopa the advent of medical therapy began and surgical approaches became less frequent...
December 23, 2019: Proceedings of the National Academy of Sciences of the United States of America
#32
JOURNAL ARTICLE
Edgar Peña, Simeng Zhang, Remi Patriat, Joshua E Aman, Jerrold L Vitek, Noam Harel, Matthew D Johnson
OBJECTIVE: The effectiveness of deep brain stimulation (DBS) therapy strongly depends on precise surgical targeting of intracranial leads and on clinical optimization of stimulation settings. Recent advances in surgical targeting, multi-electrode designs, and multi-channel independent current-controlled stimulation are poised to enable finer control in modulating pathways within the brain. However, the large stimulation parameter space enabled by these technologies also poses significant challenges for efficiently identifying the most therapeutic DBS setting for a given patient...
December 2018: Journal of Neural Engineering
#33
JOURNAL ARTICLE
Yuval Duchin, Reuben R Shamir, Remi Patriat, Jinyoung Kim, Jerrold L Vitek, Guillermo Sapiro, Noam Harel
OBJECTIVE: Deep brain stimulation (DBS) requires accurate localization of the anatomical target structure, and the precise placement of the DBS electrode within it. Ultra-high field 7 Tesla (T) MR images can be utilized to create patient-specific anatomical 3D models of the subthalamic nuclei (STN) to enhance pre-surgical DBS targeting as well as post-surgical visualization of the DBS lead position and orientation. We validated the accuracy of the 7T imaging-based patient-specific model of the STN and measured the variability of the location and dimensions across movement disorder patients...
2018: PloS One
#34
JOURNAL ARTICLE
Claudia M Hendrix, Brett A Campbell, Benjamin J Tittle, Luke A Johnson, Kenneth B Baker, Matthew D Johnson, Gregory F Molnar, Jerrold L Vitek
Many studies suggest that Parkinson's disease (PD) is associated with changes in neuronal activity patterns throughout the basal ganglia-thalamocortical motor circuit. There are limited electrophysiological data, however, describing how parkinsonism impacts the presupplementary motor area (pre-SMA) and SMA proper (SMAp), cortical areas known to be involved in movement planning and motor control. In this study, local field potentials (LFPs) were recorded in the pre-SMA/SMAp of a nonhuman primate during a visually cued reaching task...
September 1, 2018: Journal of Neurophysiology
#35
JOURNAL ARTICLE
Reuben R Shamir, Yuval Duchin, Jinyoung Kim, Remi Patriat, Odeya Marmor, Hagai Bergman, Jerrold L Vitek, Guillermo Sapiro, Atira Bick, Ruth Eliahou, Renana Eitan, Zvi Israel, Noam Harel
BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a proven and effective therapy for the management of the motor symptoms of Parkinson's disease (PD). While accurate positioning of the stimulating electrode is critical for success of this therapy, precise identification of the STN based on imaging can be challenging. We developed a method to accurately visualize the STN on a standard clinical magnetic resonance imaging (MRI). The method incorporates a database of 7-Tesla (T) MRIs of PD patients together with machine-learning methods (hereafter 7 T-ML)...
May 24, 2018: Neurosurgery
#36
JOURNAL ARTICLE
Simeng Zhang, Allison T Connolly, Lauren R Madden, Jerrold L Vitek, Matthew D Johnson
OBJECTIVE: Local field potential (LFP) recordings along a deep brain stimulation (DBS) lead can provide useful feedback for titrating DBS therapy. However, conventional DBS leads with four cylindrical macroelectrodes likely undersample the spatial distribution of sinks and sources in a given brain region. In this study, we investigated the spectral power and spatial feature sizes of LFP activity in non-human primate subthalamic nucleus and globus pallidus using chronically implanted 32-channel directional DBS arrays...
August 2018: Journal of Neural Engineering
#37
JOURNAL ARTICLE
YiZi Xiao, Filippo Agnesi, Edward M Bello, Simeng Zhang, Jerrold L Vitek, Matthew D Johnson
Deep brain stimulation (DBS) therapy is a potent tool for treating a range of brain disorders. High frequency stimulation (HFS) patterns used in DBS therapy are known to modulate neuronal spike rates and patterns in the stimulated nucleus; however, the spatial distribution of these modulated responses are not well understood. Computational models suggest that HFS modulates a volume of tissue spatially concentrated around the active electrode. Here, we tested this theory by investigating modulation of spike rates and patterns in non-human primate motor thalamus while stimulating the cerebellar-receiving area of motor thalamus, the primary DBS target for treating Essential Tremor...
February 1, 2018: Scientific Reports
#38
JOURNAL ARTICLE
Takao Hashimoto, Abirami Muralidharan, Kunihiro Yoshida, Tetsuya Goto, Takehiro Yako, Kenneth B Baker, Jerrold L Vitek
Objectives: We investigated the effects of deep brain stimulation (DBS) or lesions of the ventral intermediate nucleus (Vim) of the thalamus for spinocerebellar ataxia (SCA) and examined the pathophysiological role of neuronal activity of the Vim underlying ataxia. Methods: Five patients with SCA with cortical atrophy (ages 60-69 years; 2 sporadic and three familial SCA) and five patients with essential tremor (ET) (ages 57-71 years) were treated with Vim surgery...
January 2018: Annals of Clinical and Translational Neurology
#39
JOURNAL ARTICLE
David Escobar Sanabria, Luke A Johnson, Shane D Nebeck, Jianyu Zhang, Matthew D Johnson, Kenneth B Baker, Gregory F Molnar, Jerrold L Vitek
Oscillatory neural activity in different frequency bands and phase-amplitude coupling (PAC) are hypothesized to be biomarkers of Parkinson's disease (PD) that could explain dysfunction in the motor circuit and be used for closed-loop deep brain stimulation (DBS). How these putative biomarkers change from the normal to the parkinsonian state across nodes in the motor circuit and within the same subject, however, remains unknown. In this study, we characterized how parkinsonism and vigilance altered oscillatory activity and PAC within the primary motor cortex (M1), subthalamic nucleus (STN), and globus pallidus (GP) in two nonhuman primates...
November 1, 2017: Journal of Neurophysiology
#40
JOURNAL ARTICLE
Jing Wang, Luke A Johnson, Alicia L Jensen, Kenneth B Baker, Gregory F Molnar, Matthew D Johnson, Jerrold L Vitek
A number of studies suggest that Parkinson's disease (PD) is associated with alterations of neuronal activity patterns in the basal-ganglia-thalamocortical circuit. There are limited electrophysiological data, however, describing how the premotor cortex, which is involved in movement and decision-making, is likely impacted in PD. In this study, spontaneous local field potential (LFP) and single unit neuronal activity were recorded in the dorsal premotor area of nonhuman primates in both the naïve and parkinsonian state using the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of parkinsonism...
June 1, 2017: Journal of Neurophysiology
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