Luchen Sun, Nanfei Yang, Bing Chen, Yuncheng Bei, Zisheng Kang, Can Zhang, Nan Zhang, Peipei Xu, Wei Yang, Jia Wei, Jiangqiong Ke, Weijian Sun, Xiaokun Li, Pingping Shen
Currently the main treatment of acute myeloid leukemia (AML) is chemotherapy combining hematopoietic stem cell transplantation. However, the unbearable side effect of chemotherapy and the high risk of life-threatening infections and disease relapse following hematopoietic stem cell transplantation restrict its application in clinical practice. Thus, there is an urgent need to develop alternative therapeutic tactics with significant efficacy and attenuated adverse effects. Here, we revealed that umbilical cord-derived mesenchymal stem cells (UC-MSC) efficiently induced AML cell differentiation by shuttling the neutrophil elastase (NE)-packaged extracellular vesicles (EVs) into AML cells...
July 2023: Acta Pharmaceutica Sinica. B