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Vitamin D3 AND hypercalcemia

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https://www.readbyqxmd.com/read/27919743/dual-antiplasmodial-activity-of-vitamin-d3-and-its-analog-22-oxacalcitriol-by-direct-and-indirect-mechanisms
#1
Kiichi Yamamoto, Moritoshi Iwagami, Takenori Seki, Shigeyuki Kano, Nobuo Ota, Manabu Ato
Recent evidence suggests that 1α,25-dihydroxyvitamin D3 (calcitriol, VD3), the active form of vitamin D (VD), can inhibit the proliferation of microorganisms. In the present study, we conducted in vitro experiments and utilized in vivo murine models to investigate the antimalarial activity of VD3 and its analog, 22-oxacalcitriol (22-OCT), which was designed to cause less hypercalcemia than VD3. VD3 and 22-OCT treatments effectively resolved a Plasmodium chabaudi (Pc) infection in wild-type mice. Reduced parasitemia was observed during the acute phase of infection in the presence of VD3 and 22-OCT, followed by a delayed peak during the chronic stage of infection...
December 2, 2016: Parasitology International
https://www.readbyqxmd.com/read/27861708/high-dose-monthly-vitamin-d-for-prevention-of-acute-respiratory-infection-in-older-long-term-care-residents-a-randomized-clinical-trial
#2
Adit A Ginde, Patrick Blatchford, Keith Breese, Lida Zarrabi, Sunny A Linnebur, Jeffrey I Wallace, Robert S Schwartz
OBJECTIVES: To determine the efficacy and safety of high-dose vitamin D supplementation for prevention of acute respiratory infection (ARI) in older long-term care residents. DESIGN: Randomized controlled trial investigating high-dose vs standard-dose vitamin D from 2010 to 2014. SETTING: Colorado long-term care facilities. PARTICIPANTS: Long-term care residents aged 60 and older (n = 107). INTERVENTION: The high-dose group received monthly supplement of vitamin D3 100,000 IU, the standard-dose group received a monthly placebo (for participants taking 400-1,000 IU/d as part of usual care) or a monthly supplement of 12,000 IU of vitamin D3 (for participants taking <400 IU/d as part of usual care)...
November 16, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27822674/conversion-of-oral-alfacalcidol-to-oral-calcitriol-in-the-treatment-of-secondary-hyperparathyroidism-in-chronic-hemodialysis-patients
#3
Sandrine Rauscher, Jean-Philippe Lafrance, Vincent Pichette, Robert Z Bell, Katherine Desforges, Laurence Lepage, Georges Ouellet, Denis Ouimet, Martine Leblanc, Caroline Lamarche, Sarah Bezzaoucha, Michel Vallee
PURPOSE: The optimal vitamin D3 therapy for the treatment of secondary hyperparathyroidism (SHPT) in chronic hemodialysis patients is still controversial. Recent studies suggest that uremia in end-stage renal disease is associated with enzymatic hepatic dysfunction altering 25-hydroxylation of vitamin D3. The goal of our study was to compare the efficacy of calcitriol, the fully hydroxylated active form of vitamin D3, to alfacalcidol which needs 25-hydroxylation to be effective, for the treatment of SHPT in chronic hemodialysis patients...
November 8, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27743385/vitamin-d-in-haematological-disorders-and-malignancies
#4
Paige M Kulling, Kristine C Olson, Thomas L Olson, David J Feith, Thomas P Loughran
Commonly known for its critical role in calcium homeostasis and bone mineralization, more recently vitamin D has been implicated in haematological cancer pathogenesis and shows promise as an anti-cancer therapy. Serum levels of 25(OH)D3 , the precursor to the active form of vitamin D, calcitriol, are typically lower in patients with haematological disease compared to healthy individuals. This often correlates with worse disease outcome. Furthermore, diseased cells typically highly express the vitamin D receptor (VDR), which is required for many of the anti-cancer effects observed in multiple in vivo and in vitro cancer models...
October 15, 2016: European Journal of Haematology
https://www.readbyqxmd.com/read/27588937/vitamin-d-mediated-hypercalcemia-mechanisms-diagnosis-and-treatment
#5
Peter J Tebben, Ravinder J Singh, Rajiv Kumar
Hypercalcemia occurs in up to 4% of the population in association with malignancy, primary hyperparathyroidism, ingestion of excessive calcium and/or vitamin D, ectopic production of 1,25-dihydroxyvitamin D [1,25(OH)2D], and impaired degradation of 1,25(OH)2D. The ingestion of excessive amounts of vitamin D3 (or vitamin D2) results in hypercalcemia and hypercalciuria due to the formation of supraphysiological amounts of 25-hydroxyvitamin D [25(OH)D] that bind to the vitamin D receptor, albeit with lower affinity than the active form of the vitamin, 1,25(OH)2D, and the formation of 5,6-trans 25(OH)D, which binds to the vitamin D receptor more tightly than 25(OH)D...
October 2016: Endocrine Reviews
https://www.readbyqxmd.com/read/27515154/an-initial-loading-dose-vitamin-d-versus-placebo-after-hip-fracture-surgery-randomized-trial
#6
Jenson Cs Mak, Rebecca S Mason, Linda Klein, Ian D Cameron
BACKGROUND: Improving vitamin D (25-OHD) status may be an important modifiable factor that could reduce disability severity, fall-rates and mortality associated after hip fracture surgery. Providing a loading-dose post-surgery may overcome limitations in adherence to daily supplementation. METHOD: In this randomized, double-blind, placebo-controlled trial, 218 adults, aged 65-years or older, requiring hip fracture surgery were assigned to receive a single loading-dose of cholecalciferol (250,000 IU vitamin-D3, the REVITAHIP - Replenishment of Vitamin D in Hip Fracture strategy) or placebo, both receiving daily vitamin-D(800 IU) and calcium (500 mg) for 26-weeks...
August 11, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27510812/renal-failure-in-dogs-kept-by-a-man-with-severe-psoriasis
#7
Y Fujita, K Hanazono, E Uchida, T Kawahata, A Suto, K Nakamura, H Shimizu
Psoriasis is a common inflammatory disorder characterized by well-demarcated hyperkeratotic erythema and plaques. Topical vitamin D3 analogues are among the first-line treatments for psoriasis, and prescribed for 59.6% of psoriasis patients in Japan.(1) It is well-informed that topical application of vitamin D3 analogues can cause hypercalcemia in humans.(2) However, little is recognized by dermatologists that pets have a possibility to cause hypercalcemia, which are kept by psoriasis patients using topical vitamin D3 analogues...
August 11, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27484042/the-protective-role-of-vitamin-d3-in-a-murine-model-of-asthma-via-the-suppression-of-tgf-%C3%AE-smad-signaling-and-activation-of-the-nrf2-ho-1-pathway
#8
Zhihui Wang, Haitao Zhang, Xiaohan Sun, Lihong Ren
Asthma is a common worldwide health burden, the prevalence of which is increasing. Recently, the biologically active form of vitamin D3, 1,25-dihydroxyvitamin D3, has been reported to have a protective role in murine asthma; however, the molecular mechanisms by which vitamin D3 attenuates asthma‑associated airway injury remain elusive. In the present study, BALB/c mice were sensitized to ovalbumin (OVA) and were administered 100 ng 1,25-dihydroxyvitamin D3 (intraperitoneal injection) 30 min prior to each airway challenge...
September 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27422380/nanocapsules-with-polyelectrolyte-shell-as-a-platform-for-1-25-dihydroxyvitamin-d3-neuroprotection-study-in-organotypic-hippocampal-slices
#9
Joanna Ślusarczyk, Marek Piotrowski, Krzysztof Szczepanowicz, Magdalena Regulska, Monika Leśkiewicz, Piotr Warszyński, Bogusława Budziszewska, Władysław Lasoń, Agnieszka Basta-Kaim
Calcitriol (1,25-dihydroxyvitamin D3), an active metabolite of vitamin D3, besides the role in calcium and phosphorus metabolism, plays a role in maintaining the functions of the brain. Active forms of vitamin D3 stimulate neurotrophic factors' expression, regulate brain immune processes, and prevent neuronal damage. Therefore, a potential utility of vitamin D3 in a therapy of neurodegenerative disorders should be taken into account. On the other hand, systemic vitamin D3 treatment carries the risk of undesirable effects, e...
July 15, 2016: Neurotoxicity Research
https://www.readbyqxmd.com/read/27408382/rare-occurrence-of-3-h-hypercalcemia-hemolytic-anemia-and-hodgkin-s-lymphoma
#10
Ankur Jain, Pankaj Malhotra, Gaurav Prakash, Subhash Varma, Narender Kumar, Asim Das
Clinicians in hematology practice commonly encounter anemia, hypercalcemia and renal failure, which when present in combination evoke a diagnostic workup for multiple myeloma. We report a 71-years old lady who presented to our hematology clinic with fever and easy fatiguability of 3 months duration and on investigations was found to have anemia and hypercalcemia. Direct Coomb's test characterized the anemia as complement mediated (anti-C3d) hemolysis. Biochemical investigations revealed normal 25(OH) Vitamin D3 and suppressed Parathormone levels and a negative workup for plasma cell dyscrasias, sarcoidosis and autoimmune disorders...
June 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27366711/prevalence-and-severity-of-disordered-mineral-metabolism-in-patients-with-chronic-kidney-disease-a-study-from-a-tertiary-care-hospital-in-india
#11
Sanjay Vikrant, Anupam Parashar
BACKGROUND: Disordered mineral metabolism is common complications of chronic kidney disease (CKD). However, there are limited data on the pattern of these disturbances in Indian CKD population. MATERIALS AND METHODS: This was a prospective observational study of CKD-mineral and bone disorder (CKD-MBD) over a period of 3 years. The biochemical markers of CKD-MBD, namely, calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone (iPTH), and 25-hydoxyvitamin Vitamin D3 (25OHD), were measured in newly diagnosed CKD Stage 3-5 and prevalent CKD Stage 5D adult patients...
July 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27358053/a-model-of-calcium-homeostasis-in-the-rat
#12
David Granjon, Olivier Bonny, Aurélie Edwards
We developed a model of calcium homeostasis in the rat in order to better understand the impact of dysfunctions such as primary hyperparathyroidism and vitamin D deficiency on calcium balance. The model accounts for the regulation of calcium intestinal uptake, bone resorption, and renal reabsorption by parathyroid hormone (PTH), vitamin D3, and Ca2+ itself. It is the first such model to incorporate recent findings regarding the role of the calcium sensing receptor (CaSR) in the kidney, the presence of a rapidly exchangeable pool in bone, and the delayed response of vitamin D3 synthesis...
June 29, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27333923/efficacy-and-safety-of-vitamin-d-supplementation-in-patients-with-chronic-lymphocytic-leukemia
#13
Marcin Kubeczko, Elżbieta Nowara, Wojciech Spychałowicz, Kamil Wdowiak, Anna Bednarek, Dobromiła Karwasiecka, Jerzy Chudek, Jerzy Wojnar
BACKGROUND: Vitamin D (VD) deficiency in chronic lymphocytic leukemia (CLL) is associated with inferior prognosis, shorter time to treatment and worse overall survival. VD deficiency is the first potentially modifiable prognostic factor in CLL. Currently, however, there is a lack of studies concerning VD supplementation in CLL patients. AIM: To evaluate the efficacy and safety of VD supplementation in patients with CLL. METHODS: A 6-month interventional study was conducted in CLL patients with lower serum 25-OH-D3 concentrations (< 30 ng/ml) than currently recommended...
2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27321871/calcium-effects-and-systemic-exposure-of-vitamin-d3-analogues-after-topical-treatment-of-active-vitamin-d3-containing-ointments-in-rats
#14
Atsushi Hosomi, Maho Hirabe, Takuya Tokuda, Hiroaki Nakamura, Toru Amano, Tadao Okamoto
Topical agents containing vitamin D3 (VD3) analogues such as calcipotriol, maxacalcitol and tacalcitol and the combination of calcipotriol/betamethasone dipropionate (betamethasone) are prescribed for patients with psoriasis. However, they are known to occasionally cause hypercalcemia, and the frequency of hypercalcemia is suggested to vary according to the VD3 analogue used. In this study, to address the reason for these differences, the calcemic effects of maxacalcitol-, calcipotriol- and calcipotriol/betamethasone-containing ointments in rats were evaluated...
October 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27259026/hypercalcemia-in-a-dog-with-chronic-ingestion-of-maxacalcitol-ointment
#15
Kensuke Nakamura, Nobuo Tohyama, Masahiro Yamasaki, Hiroshi Ohta, Keitaro Morishita, Mitsuyoshi Takiguchi
A miniature dachshund male with severe azotemia of unknown cause was referred. Serum biochemistry revealed severe azotemia and hypercalcemia, but serum intact parathormone and parathormone-related protein were normal. Although the owner reported that the dog had never ingested any drugs or supplements, it was revealed that the owner's son used antipsoriatic ointment, maxacalcitol, which contained an active vitamin D3 analogue, daily and the dog often ate the son's dander and licked his skin, especially after he applied the maxacalcitol ointment...
July 2016: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/27243456/chronic-vitamin-d-intoxication-in-captive-iberian-lynx-lynx-pardinus
#16
Ignacio Lopez, Carmen Pineda, Luis Muñoz, Ana Raya, Guillermo Lopez, Escolástico Aguilera-Tejero
To document the biochemical and pathologic features of vitamin D intoxication in lynx and to characterize mineral metabolism in healthy lynx, blood samples were obtained from 40 captive lynx that had been receiving excessive (approximately 30 times the recommended dose) vitamin D3 in the diet, and from 29 healthy free ranging lynx. Tissue samples (kidney, stomach, lung, heart and aorta) were collected from 13 captive lynx that died as a result of renal disease and from 3 controls. Vitamin D intoxication resulted in renal failure in most lynx (n = 28), and widespread extraskeletal calcification was most severe in the kidneys and less prominent in cardiovascular tissues...
2016: PloS One
https://www.readbyqxmd.com/read/27096733/use-of-2md-a-novel-oral-calcitriol-analog-in-hemodialysis-patients-with-secondary-hyperparathyroidism
#17
Richa Pandey, Julia Zella, Margaret Clagett-Dame, Lori A Plum, Hector F DeLuca, Daniel W Coyne
BACKGROUND: Use of existing therapies for secondary hyperparathyroidism (SHPT), such as calcitriol or paricalcitol, is frequently limited by the development of hypercalcemia. 2-Methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D3 (2MD; DP001) is a novel and a more potent vitamin D receptor activator (VDRA) that more selectively localizes in the parathyroid gland, and has a wider therapeutic margin in the uremic rat model than calcitriol and paricalcitol. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: Hemodialysis patients were enrolled and dosed with 110, 220, 330, 440, or 550 ng of 2MD orally thrice weekly for 4 weeks...
2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27076675/evaluation-of-responses-to-vitamin-d3-cholecalciferol-in-patients-on-dialysis-a-systematic-review-and-meta-analysis
#18
Chen Xu, Yan-Chun Li, Su-Mei Zhao, Zhong-Xin Li
Vitamin D plays a key role in mineral metabolism and its deficiency is often noted in patients on dialysis for end-stage renal disease (ESRD). We evaluated the efficacy and responses to vitamin D3 (cholecalciferol) in patients undergoing dialysis for ESRD. Randomized controlled trials or prospective studies comparing vitamin D3 supplementation to placebo in patients with ESRD on dialysis were searched from medical databases using the terms, 'Calcitriol/Cholecalciferol, vitamin D, chronic kidney disease, hemodialysis, serum calcium, parathyroid hormones (PTH), phosphorus, 25(OH)D, and 1,25(OH)2D'...
June 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/27011794/vitamin-d-supplementation-decreases-aspergillus-fumigatus-specific-th2-responses-in-cf-patients-with-aspergillus-sensitization-a-phase-one-open-label-study
#19
Nikki Lynn Hue Nguyen, Joseph M Pilewski, Juan C Celedón, Sivanarayana Mandalapu, Megan L Blanchard, Adrienne DeRicco, Elizabeth Hartigan, John F Alcorn, Jay K Kolls
BACKGROUND: Patients with cystic fibrosis (CF) complicated by allergic bronchopulmonary aspergillosis (ABPA) are vitamin D deficient and in vitro treatment with 1,25 (OH)2 vitamin D3 of CD4+ cells from CF patients with ABPA decreases Aspergillus fumigatus(Af)-induced Th2 responses. This Phase I clinical trial investigated the safety and effectiveness of daily vitamin D3 supplementation in CF patients with ABPA to reduce allergic responses and ABPA symptoms, and increase serum vitamin D levels...
2015: Asthma research and practice
https://www.readbyqxmd.com/read/26964622/gsk-3-inhibition-sensitizes-acute-myeloid-leukemia-cells-to-1-25d-mediated-differentiation
#20
Kalpana Gupta, Tammy Stefan, James Ignatz-Hoover, Stephen Moreton, Gary Parizher, Yogen Saunthararajah, David N Wald
1,25-dihydroxyvitamin D3 (1,25D), the biologically active form of vitamin D, is widely considered a promising therapy for acute myeloid leukemia (AML) based on its ability to drive differentiation of leukemic cells. However, clinical trials have been disappointing in part to dose-limiting hypercalcemia. Here we show how inhibiting glycogen synthase kinase 3 (GSK3) can improve the differentiation response of AML cells to 1,25D-mediated differentiation. GSK3 inhibition in AML cells enhanced the differentiating effects of low concentrations of 1,25D...
May 1, 2016: Cancer Research
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