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https://www.readbyqxmd.com/read/28620866/high-levels-of-igf-1-predict-difficult-intubation-of-patients-with-acromegaly
#1
Yu Zhang, Xiaopeng Guo, Lijian Pei, Zhuhua Zhang, Gang Tan, Bing Xing
PURPOSE: To investigate the characteristics of difficult intubation and identify novel efficient predictors in patients with acromegaly. METHODS: Patients with either untreated acromegaly or non-functional pituitary adenomas were enrolled. Patients with acromegaly underwent hormone assays, upper airway computed tomography and magnetic resonance imaging examinations and preoperative overnight polysomnography. The modified Mallampati classification, mouth opening, neck circumference, and neck extension were assessed, and the Cormack-Lehane grades and the time of tracheal intubation were recorded...
June 15, 2017: Endocrine
https://www.readbyqxmd.com/read/28618777/rare-earth-pcu-mof-platform-based-on-re4-%C3%AE-3-oh-4-coo-62-clusters-rational-design-directed-synthesis-and-deliberate-tuning-of-excitation-wavelengths
#2
Tian-Yi Luo, Chong Liu, Svetlana V Eliseeva, Patrick Flynn Muldoon, Stephane Petoud, Nathaniel L Rosi
The Td point group symmetry of rare earth (RE3+) metal clusters RE4(μ3-OH)4(COO)62+ makes them attractive building blocks for creating metal-organic frameworks (MOFs) with controllable topologies. Herein, we describe the design and synthesis of a series of isoreticular MOFs featuring pcu topology [MOF-1114(RE) and MOF-1115(RE)] with variable rare earth metal ions (RE3+ = Y3+, Sm3+, Eu3+, Gd3+, Tb3+, Dy3+, Ho3+, Er3+, Tm3+, Yb3+) and linear amino-functionalized dicarboxylate linkers of different lengths. In total, we report 22 MOFs that vary in both composition and structure yet share the same RE4(μ3-OH)4 cluster motif...
June 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28613454/changes-in-undergraduates-marijuana-heavy-alcohol-and-cigarette-use-following-legalization-of-recreational-marijuana-use-in-oregon
#3
David C R Kerr, Harold Bae, Sandi Phibbs, Adam C Kern
BACKGROUND AND AIMS: Recreational marijuana legalization (RML) went into effect in Oregon in July 2015. RML is expected to influence marijuana use by adolescents and young adults in particular, and by those with a propensity for substance use. We sought to quantify changes in rates of marijuana use among college students in Oregon from pre- to post-RML relative to college students in other states across the same time period. DESIGN: Repeated cross-sectional survey data from the 2012-2016 administrations of the Healthy Minds Study...
June 14, 2017: Addiction
https://www.readbyqxmd.com/read/28613083/the-aldh2-gene-rs671-polymorphism-is-not-associated-with-essential-hypertension
#4
Zhan-Ming Li, Chao-Yue Kong, Ke-Yu Sun, Li-Shun Wang
Essential hypertension (EH) is a worldwide problem. Acetaldehyde dehydrogenase 2 (ALDH2) gene has been suggested to be correlated with EH. However, the results are inconsistent. This study aimed to investigate the associations of ALDH2 rs671 polymorphism with EH in a Chinese Han population in Shanghai. Genotype of ALDH2 rs671 was analyzed in 1923 EH patients and 1115 control subjects. We found no association between ALDH2 rs671 and EH risk or EH-related quantitative blood chemistry values. Furthermore, a meta-analysis was performed and the summary results from 11220 patients and 8339 control subjects were consistent with our findings...
June 14, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28572788/corrigendum-what-the-heck-is-salience-how-predictive-language-processing-contributes-to-sociolinguistic-perception
#5
T Florian Jaeger, Kodi Weatherholtz
[This corrects the article on p. 1115 in vol. 7, PMID: 27536257.].
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28539206/prediabetes-is-not-a-risk-factor-for-subclinical-coronary-atherosclerosis
#6
Gyung-Min Park, Young-Rak Cho, Seung-Whan Lee, Sung-Cheol Yun, Ki-Bum Won, Soe Hee Ann, Yong-Giun Kim, Shin-Jae Kim, Jae-Hyung Roh, Young-Hak Kim, Dong Hyun Yang, Joon-Won Kang, Tae-Hwan Lim, Chang Hee Jung, Eun Hee Koh, Woo Je Lee, Min-Seon Kim, Ki-Up Lee, Joong-Yeol Park, Hong-Kyu Kim, Jaewon Choe, Sang-Gon Lee
BACKGROUND: There are limited data regarding the influence of glycemic status on the risk of subclinical coronary atherosclerosis on coronary computed tomographic angiography (CCTA) in asymptomatic individuals. METHODS: We analyzed 6434 asymptomatic individuals who underwent CCTA. The degree and extent of subclinical coronary atherosclerosis were assessed by CCTA, and ≥50% diameter stenosis was defined as significant. Of study participants, 2197 (34.1%), 3122 (48...
May 19, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28461698/genetic-risk-for-schizophrenia-and-psychosis-in-alzheimer-disease
#7
M A A DeMichele-Sweet, E A Weamer, L Klei, D T Vrana, D J Hollingshead, H J Seltman, R Sims, T Foroud, I Hernandez, S Moreno-Grau, L Tárraga, M Boada, A Ruiz, J Williams, R Mayeux, O L Lopez, E L Sibille, M I Kamboh, B Devlin, R A Sweet
Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD), affecting ~40 to 60% of individuals with AD (AD with psychosis (AD+P)). In comparison with AD subjects without psychosis, AD+P subjects have more rapid cognitive decline and poor outcomes. Prior studies have estimated the heritability of psychosis in AD at 61%, but the underlying genetic sources of this risk are not known. We evaluated a Discovery Cohort of 2876 AD subjects with (N=1761) or without psychosis (N=1115)...
May 2, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28460083/estimated-medical-expenditure-and-risk-of-job-loss-among-rheumatoid-arthritis-patients-undergoing-tofacitinib-treatment-post-hoc-analyses-of-two-randomized-clinical-trials
#8
Regina Rendas-Baum, Mark Kosinski, Amitabh Singh, Charles A Mebus, Bethany E Wilkinson, Gene V Wallenstein
Objectives.: RA causes high disability levels and reduces health-related quality of life, triggering increased costs and risk of unemployment. Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. These post hoc analyses of phase 3 data aimed to assess monthly medical expenditure (MME) and risk of job loss for tofacitinib treatment vs placebo. Methods.: Data analysed were from two randomized phase 3 studies of RA patients (n = 1115) with inadequate response to MTX or TNF inhibitors (TNFi) receiving tofacitinib 5 or 10 mg twice daily, adalimumab (one study only) or placebo, in combination with MTX...
April 28, 2017: Rheumatology
https://www.readbyqxmd.com/read/28409919/atomic-layer-deposition-functionalized-carbonized-mesoporous-wood-fiber-for-high-sulfur-loading-lithium-sulfur-batteries
#9
Chao Luo, Hongli Zhu, Wei Luo, Fei Shen, Xiulin Fan, Jiaqi Dai, Yujia Liang, Chunsheng Wang, Liangbing Hu
Lithium-sulfur battery (LSB) as one of the most promising energy storage devices suffers from poor conductivity of sulfur and fast capacity decay triggered by the dissolution of polysulfides. In this work, functionalized carbonized mesoporous wood fiber (f-CMWF) is employed as a host to accommodate sulfur for the first time. Natural wood microfiber has unique hierarchical and mesoporous structure, which is well-maintained after carbonization. With such a hierarchical mesoporous structure, a high sulfur loading of 76 wt % is achieved in CMWF electrodes...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28391549/disease-burden-of-mild-asthma-findings-from-a-cross-sectional-real-world-survey
#10
Bo Ding, Mark Small
INTRODUCTION: Most asthma patients have mild disease, although the burden of mild asthma is not well understood nor studied. Some evidence suggests that many patients with mild asthma experience suboptimal symptom control and exacerbations. This study characterizes the burden of illness and treatment patterns among patients with a confirmed diagnosis of mild asthma, defined as GINA Step 1 or Step 2, and residing in China, France, Germany, Italy, Japan, Spain, the United Kingdom, or the United States...
May 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28381134/head-impact-density-a-model-to-explain-the-elusive-concussion-threshold
#11
Steven P Broglio, Andrew Lapointe, Kathryn L O'Connor, Michael McCrea
Concussion is a heterogeneous injury occurring throughout a range of impact magnitudes. Consequently, research focusing on a single or set of variables at the time of injury to understand concussive biomechanics has been thwarted by low injury prediction sensitivity. The current study examined the role of Impact Density in estimating concussive injury risk. Head impact data were collected across seven high school football seasons with the Head Impact Telemetry System (HIT System). Over the study period, 29 concussions were included for data analysis...
May 24, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28359865/transcriptomic-analysis-of-two-beauveria-bassiana-strains-grown-on-cuticle-extracts-of-the-silkworm-uncovers-their-different-metabolic-response-at-early-infection-stage
#12
Jing-Jie Wang, Wen-Wen Bai, Wei Zhou, Jing Liu, Jie Chen, Xiao-Yuan Liu, Ting-Ting Xiang, Ren-Hua Liu, Wen-Hui Wang, Bao-Ling Zhang, Yong-Ji Wan
Beauveria bassiana is an important entomopathogenic fungus which not only widely distributes in the environment but also shows phenotypic diversity. However, the mechanism of pathogenic differences among natural B. bassiana strains has not been revealed at transcriptome-wide level. In the present study, in order to explore the mechanism, two B. bassiana strains with different pathogenicity were isolated from silkworms (Bombyx mori L.) and selected to analyze the gene expression of early stage by culturing on cuticle extracts of the silkworm and using RNA-sequencing technique...
March 27, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28353335/porous-functionalized-self-standing-carbon-fiber-paper-electrodes-for-high-performance-capacitive-energy-storage
#13
Yuanyuan Zhu, Shuang Cheng, Weijia Zhou, Jin Jia, Lufeng Yang, Minghai Yao, Mengkun Wang, Peng Wu, Haowei Luo, Meilin Liu
A facile and cost-efficient approach to functionalize raw carbon fiber paper (CFP) used for a self-standing capacitive electrode has been proposed here. Benefiting from the improved specific surface area and surface functional groups, the functionalized CFP (F-CFP) showed much enhanced capacitive performance, 3 orders of magnitude higher than that of the raw CFP. It delivered the areal capacitance of 1275 mF cm(-2) at 5 mA cm(-2) with a rather wide voltage window of 1.4 V (-0.4 to 1 V vs Ag/AgCl) in 0.5 M H2SO4...
April 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28319531/examination-of-the-life-expectancy-of-patients-with-burns-over-20-of-their-total-body-surface-area-in-comparison-to-the-rest-of-the-population
#14
Oren Weissman, Yonathan Wagman, Adi Givon, Irina Radomislensky, Kobi Peleg, Demetris Stavrou, Josef Haik, Ariel Tessone
Patients with extensive burn injuries suffer from multisystem trauma, which affects their medical, psychological, and social well-being for many years. Monitoring those patients has revealed changes in the endocrine, cardiac, and respiratory systems years after the injury. Our study tries to examine whether changes manifest as a higher risk of death during their lifespan, compared with the general population. Data from the years 1998 to 2013 regarding two groups of patients was obtained from a national trauma registry: one group had suffered burns over 20% of their TBSA and survived the hospitalization period and the second group was a control group of patients admitted with minimal trauma (Injury Severity Score = 1-minor injury to a single body region)...
March 28, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28284552/mussels-as-bioindicators-of-diclofenac-contamination-in-coastal-environments
#15
S C Cunha, A Pena, J O Fernandes
Diclofenac a nonsteroidal anti-inflammatory drug (NSAID) has been confirmed as an emerging contaminant in the aquatic environment. Toxicology studies have revealed that harmful effects may emerge from diclofenac presence not only for human health, but also for marine organisms, which implies its monitoring. To overcome the demanding challenges of diclofenac quantification in biotic aquatic species, a novel method for the determination of diclofenac in mussels (Mytilus galloprovincialis and Mytilus edulis) and macroalgae (Laminaria digitata) using high performance liquid chromatography coupled to tandem mass spectrometry was developed and validated according to the EC Decision 2002/657/EC...
March 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28225374/characterizing-the-toxicity-and-dose-effect-profile-of-tramadol-ingestions-in-children
#16
Gina L Stassinos, Lawrence Gonzales, Wendy Klein-Schwartz
OBJECTIVES: Tramadol can cause life-threatening toxicity in overdose; however, data on its toxicity in children are lacking. This study investigates toxicity associated with tramadol ingestions in children. The hypothesis is that children will experience dose-related central nervous system and respiratory depression and seizures. METHODS: A retrospective evaluation of cases from the National Poison Center Data System between January 1, 2000, and December 31, 2013, was performed...
February 21, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28179220/modifiable-risk-factors-versus-age-on-developing-high-predicted-cardiovascular-disease-risk-in-blacks
#17
Adam P Bress, Lisandro D Colantonio, John N Booth, Tanya M Spruill, Joseph Ravenell, Mark Butler, Amanda J Shallcross, Samantha R Seals, Kristi Reynolds, Gbenga Ogedegbe, Daichi Shimbo, Paul Muntner
BACKGROUND: Clinical guidelines recommend using predicted atherosclerotic cardiovascular disease (ASCVD) risk to inform treatment decisions. The objective was to compare the contribution of changes in modifiable risk factors versus aging to the development of high 10-year predicted ASCVD risk. METHODS AND RESULTS: A prospective follow-up was done of the Jackson Heart Study, an exclusively black cohort at visit 1 (2000-2004) and visit 3 (2009-2012). Analyses included 1115 black participants without high 10-year predicted ASCVD risk (<7...
February 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28153478/perfusion-index-and-pulse-oximetry-screening-for-congenital-heart-defects
#18
MULTICENTER STUDY
Federico Schena, Irene Picciolli, Massimo Agosti, Antonio Alberto Zuppa, Gianvincenzo Zuccotti, Luciana Parola, Giulia Pomero, Giorgio Stival, Markus Markart, Silvia Graziani, Luigi Gagliardi, Cristina Bellan, Simona La Placa, Giuseppe Limoli, Gabriella Calzetti, Andrea Guala, Enza Bonello, Fabio Mosca
OBJECTIVE: To evaluate the efficacy of combined pulse oximetry (POX) and perfusion index (PI) neonatal screening for severe congenital heart defects (sCHD) and assess different impacts of screening in tertiary and nontertiary hospitals. STUDY DESIGN: A multicenter, prospective study in 10 tertiary and 6 nontertiary maternity hospitals. A total of 42 169 asymptomatic newborns from among 50 244 neonates were screened; exclusion criteria were antenatal sCHD diagnosis, postnatal clinically suspected sCHD, and neonatal intensive care unit admission...
April 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28152677/economic-burden-of-common-adverse-events-aes-associated-with-metastatic-colorectal-cancer-mcrc-treatment-in-the-united-states-us
#19
Jane Chang, Annie Guerin, Sherry Shi, Ed Wang, Justin Yu, Christopher Ngai
21 Background: Treatments for mCRC have distinct safety and tolerability profiles. Common AEs associated with mCRC treatments may compromise the course of treatment, worsen quality of life, and increase healthcare resource utilization and costs. This study assessed the costs of common AEs in mCRC patients (pts) in the US. METHODS: Adult mCRC pts treated with chemotherapy (chemo) or targeted therapies were identified from the Truven MarketScan databases (2009 - 2014). Up to the first 3 mCRC treatment episodes were considered...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28139135/plasma-volume-status-predicts-prognosis-in-patients-with-acute-heart-failure-syndromes
#20
Akiomi Yoshihisa, Satoshi Abe, Yu Sato, Shunsuke Watanabe, Tetsuro Yokokawa, Shunsuke Miura, Tomofumi Misaka, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Shu-Ichi Saitoh, Yasuchika Takeishi
BACKGROUND: The intravascular compartment is known as the plasma volume, and the extravascular compartment represents fluid within the interstitial space. Plasma volume expansion is a major symptom of heart failure. The aim of the current study was to investigate the impact of plasma volume status on the prognosis of acute heart failure syndromes. METHODS AND RESULTS: We analyzed 1115 patients with acute heart failure syndromes who were admitted to our hospital...
January 1, 2017: European Heart Journal. Acute Cardiovascular Care
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