Felipe A Rós, Péricles N M da Costa, Jonathan Milhomens, Débora G L de La-Roque, Fernanda U Ferreira, Juliana de Matos Maçonetto, Camila C de Oliveira Menezes Bonaldo, Julianne V de Carvalho, Patrícia V B Palma, Wassim El Nemer, Dimas T Covas, Simone Kashima
BACKGROUND AND OBJECTIVES: Bone marrow mesenchymal stromal cells (BM-MSCs) are key elements of the hematopoietic niche and participate in the regulatory mechanisms of hematopoietic stem cells (HSCs). Hematological diseases can affect MSCs and their functions. However, the dysregulations caused by sickle cell disease (SCD) are not fully elucidated. This work explored changes in BM-MSCs and their relationship with age using sickle cell mice (Townes-SS). MATERIALS AND METHODS: BM-MSCs were isolated from Townes-SS, and control groups 30- and 60-day-old Townes-AA and C57BL/6 J...
March 22, 2024: Hematology/oncology and Stem Cell Therapy