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https://www.readbyqxmd.com/read/28096297/frontline-science-tumor-necrosis-factor-%C3%AE-stimulation-and-priming-of-human-neutrophil-granule-exocytosis
#1
Kenneth R McLeish, Michael L Merchant, T Michael Creed, Shweta Tandon, Michelle T Barati, Silvia M Uriarte, Richard A Ward
Neutrophil granule exocytosis plays an important role in innate and adaptive immune responses. The present study examined TNF-α stimulation or priming of exocytosis of the 4 neutrophil granule subsets. TNF-α stimulated exocytosis of secretory vesicles and gelatinase granules and primed specific and azurophilic granule exocytosis to fMLF stimulation. Both stimulation and priming of exocytosis by TNF-α were dependent on p38 MAPK activity. Bioinformatic analysis of 1115 neutrophil proteins identified by mass spectrometry as being phosphorylated by TNF-α exposure found that actin cytoskeleton regulation was a major biologic function...
January 17, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28079763/the-comparison-of-etomidate-and-propofol-anesthesia-in-patients-undergoing-gastrointestinal-endoscopy-a-systematic-review-and-meta-analysis
#2
Limin Ye, Xiangyang Xiao, Liyi Zhu
INTRODUCTION: Etomidate and propofol played an important role in the sedation of patients undergoing gastrointestinal endoscopy. We conducted a systematic review and meta-analysis to compare their efficacy and safety. MATERIALS AND METHODS: PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials assessing the effect of etomidate versus propofol for the anesthesia of patients undergoing gastrointestinal endoscopy were included...
January 10, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28034524/maternal-immunoglobulin-g-avidity-as-a-diagnostic-tool-to-identify-pregnant-women-at-risk-of-congenital-cytomegalovirus-infection
#3
Masatoki Kaneko, Masanao Ohhashi, Toshio Minematsu, Junsuke Muraoka, Kazumi Kusumoto, Hiroshi Sameshima
BACKGROUND: The immunoglobulin (Ig) G avidity index (AI) is useful to detect primary cytomegalovirus (CMV) infection. However, because IgG matures with time, this index is not useful to detect a primary infection, unless measured at an appropriate time. OBJECTIVES: We aimed to clarify the difference between using IgG AI and IgM positivity according to the stage of pregnancy to identify congenital CMV infection risk. STUDY DESIGN: We collected the serum samples from 1115 pregnant women who underwent maternal screening for primary infection (n = 956) and were referred to our hospital because of CMV IgM positivity (n = 155) or had abnormal fetal ultrasonography findings (n = 4)...
December 26, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28032108/faunal-distribution-and-seasonal-bio-ecology-of-naturally-infected-sand-flies-in-a-new-endemic-zoonotic-cutaneous-leishmaniasis-focus-of-southern-iran
#4
Kourosh Azizi, Hayedeh Parvinjahromi, Mohammad Djaefar Moemenbellah-Fard, Bahador Sarkari, Mohammad Reza Fakoorziba
BACKGROUND: Cutaneous leishmaniasis is a major health problem in Iran in spite of implementation of control program. This infectious disease caused morbidity in less than 27000 people in 2010. This study was set to determine some ecological aspects of sand flies in Fasa district, Fars Province, southern Iran during 2011-2012. METHODS: A total of 4792 sand flies were captured by means of sticky paper and CDC miniature light traps in 10 selected villages from the beginning to the end of the active season, from which 1115 specimens were captured for abundance study and 3677 specimens captured for monitoring monthly activities in Fasa...
December 2016: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/28008867/dolutegravir-plasma-concentrations-according-to-companion-antiretroviral-drug-unwanted-drug-interaction-or-desirable-boosting-effect
#5
Dario Cattaneo, Davide Minisci, Valeria Cozzi, Agostino Riva, Paola Meraviglia, Emilio Clementi, Massimo Galli, Cristina Gervasoni
BACKGROUND: Studies in healthy volunteers have shown that the recently approved HIV integrase inhibitor dolutegravir has limited drug-to-drug interaction profile. Here we carried out a pharmacokinetic survey in HIV-infected patients given dolutegravir as part of their antiretroviral therapy. METHODS: Dolutegravir plasma trough concentrations were measured in 78 HIV infected patients given the drug in combination with a protease inhibitor, a non nucleoside reverse transcriptase inhibitor or abacavir/lamivudine...
December 23, 2016: Antiviral Therapy
https://www.readbyqxmd.com/read/28007801/rhetoric-and-reform-in-waiver-states
#6
Colleen M Grogan, Phillip M Singer, David K Jones
Seven states have used Section 1115 waivers to expand Medicaid as part of the Affordable Care Act (ACA). While each state pursued a unique plan, there are similarities in the types of changes each state desired to make. Equally important to how a state modified their Medicaid programs is how a state talked about Medicaid and reform. We investigate whether the rhetoric that emerged in waiver states is unique, analyze whether the rhetoric is associated with particular waiver reforms, and consider the implications of our findings for the future of Medicaid policy making...
December 22, 2016: Journal of Health Politics, Policy and Law
https://www.readbyqxmd.com/read/28005234/the-genetic-diversity-and-complete-genome-analysis-of-two-novel-porcine-deltacoronavirus-isolates-in-thailand-in-2015
#7
Athip Lorsirigool, Kepalee Saeng-Chuto, Adthakorn Madapong, Gun Temeeyasen, Thitima Tripipat, Pavita Kaewprommal, Angkana Tantituvanont, Jittima Piriyapongsa, Dachrit Nilubol
Porcine deltacoronavirus (PDCoV) was identified in intestinal samples collected from piglets with diarrhea in Thailand in 2015. Two Thai PDCoV isolates, P23_15_TT_1115 and P24_15_NT1_1215, were isolated and identified. The full-length genome sequences of the P23_15_TT_1115 and P24_15_NT1_1215 isolates were 25,404 and 25,407 nucleotides in length, respectively, which were relatively shorter than that of US and China PDCoV. The phylogenetic analysis based on the full-length genome demonstrated that Thai PDCoV isolates form a new cluster separated from US and China PDCoV but relatively were more closely related to China PDCoV than US isolates...
December 22, 2016: Virus Genes
https://www.readbyqxmd.com/read/28003151/urogenital-schistosomiasis-during-pregnancy-is-associated-with-low-birth-weight-delivery-analysis-of-a-prospective-cohort-of-pregnant-women-and-their-offspring-in-gabon
#8
Ghyslain Mombo-Ngoma, Josiane Honkpehedji, Arti Basra, Jean Rodolphe Mackanga, Rella Manego Zoleko, Jeannot Zinsou, Jean Claude Dejon Agobe, Bertrand Lell, Pierre-Blaise Matsiegui, Raquel Gonzales, Selidji Todagbe Agnandji, Maria Yazdanbakhsh, Clara Menendez, Peter G Kremsner, Ayola Akim Adegnika, Michael Ramharter
An estimated 40 million women of childbearing age suffer from schistosomiasis. Animal models indicate a deleterious effect of maternal schistosomiasis on pregnancy outcomes. To date there is a lack of epidemiological evidence evaluating schistosomiasis-related morbidity in pregnancy. This study was designed to describe the impact of urogenital schistosomiasis on pregnancy outcomes in a highly endemic region of central Africa. Pregnant women attending antenatal clinics in Fougamou and Lambaréné, Gabon, were consecutively screened for the presence of Schistosoma haematobium eggs in diurnal urine samples...
December 18, 2016: International Journal for Parasitology
https://www.readbyqxmd.com/read/27993369/marine-litter-abundance-and-distribution-on-beaches-on-the-isle-of-r%C3%A3-gen-considering-the-influence-of-exposition-morphology-and-recreational-activities
#9
Elena Hengstmann, Dennis Gräwe, Matthias Tamminga, Elke Kerstin Fischer
The abundance, weight and composition of marine debris were determined at the northwest coast of the Isle of Rügen in 2015. A total number of 1115 macrolitter items were registered, resulting in an abundance of 304±88.96 items per 100m of beach length and therefore being greater than the abundances found for other beaches at the Baltic Sea. Macrolitter items were predominantly composed of plastic, on average 83%. The four beaches under investigation have different exposition as well as touristic levels. The differing influence of wind and water currents as well as recreational activities on the macrolitter at these beaches was detectable...
December 16, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27986523/outcome-of-patients-with-venous-thromboembolism-and-factor-v-leiden-or-prothrombin-20210-carrier-mutations-during-the-course-of-anticoagulation
#10
Inna Tzoran, Manolis Papadakis, Benjamin Brenner, Ángeles Fidalgo, Agustina Rivas, Philip S Wells, Olga Gavín, María Dolores Adarraga, Farès Moustafa, Manuel Monreal
BACKGROUND: Individuals with factor V Leiden or prothrombin G20210A mutations are at a higher risk to develop venous thromboembolism. However, the influence of these polymorphisms on patient outcome during anticoagulant therapy has not been consistently explored. METHODS: We used the Registro Informatizado de Enfermedad TromboEmbólica database to compare rates of venous thromboembolism recurrence and bleeding events occurring during the anticoagulation course in factor V Leiden carriers, prothrombin mutation carriers, and noncarriers...
December 14, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27977834/high-resolution-adaptive-optics-retinal-image-analysis-at-early-stage-central-areolar-choroidal-dystrophy-with-prph2-mutation
#11
Kiyoko Gocho, Keiichiro Akeo, Naoko Itoh, Shuhei Kameya, Takaaki Hayashi, Satoshi Katagiri, Tamaki Gekka, Yasuhiro Ohkuma, Hiroshi Tsuneoka, Hiroshi Takahashi
BACKGROUND AND OBJECTIVE: To report the clinical features of Japanese patients at Stage 1 and 2 of central areolar choroidal dystrophy (CACD). PATIENTS AND METHODS: Five family members had comprehensive ophthalmic examinations including adaptive optics (AO) retinal imaging. Mutation analysis of the PRPH2 gene was performed by Sanger sequencing. The protocol conformed to the tenets of the Declaration of Helsinki and was approved by the institutional review board of The Jikei University School of Medicine...
December 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/27898763/fine-mapping-of-resistance-genes-from-five-brown-stem-rot-resistance-sources-in-soybean
#12
Keith Rincker, Glen L Hartman, Brian W Diers
Brown stem rot (BSR) of soybean [ (L.) Merr.] caused by (Allington & Chamb.) T.C. Harr. & McNew can be controlled effectively with genetic host resistance. Three BSR resistance genes , , and , have been identified and mapped to a large region on chromosome 16. Marker-assisted selection (MAS) will be more efficient and gene cloning will be facilitated with a narrowed genomic interval containing an gene. The objective of this study was to fine map the positions of genes from five sources. Mapping populations were developed by crossing the resistant sources 'Bell', PI 84946-2, PI 437833, PI 437970, L84-5873, and PI 86150 with either the susceptible cultivar Colfax or Century 84...
March 2016: Plant Genome
https://www.readbyqxmd.com/read/27859935/single-nucleotide-polymorphisms-within-micrornas-microrna-targets-and-microrna-biogenesis-genes-and-their-impact-on-colorectal-cancer-survival
#13
Lila E Mullany, Jennifer S Herrick, Roger K Wolff, Martha L Slattery
We have shown that single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, miRNA target genes, and miRNA biogenesis genes minimally contribute to colon cancer risk. It is possible that these SNPs alter survival. We analyzed 565 SNPs in or adjacent to microRNAs, target genes, or biogenesis genes, using 1115 cases and 1173 controls; 837 cases had survival information. We tested SNPs for associations with colorectal cancer (CRC) survival using a Cox proportional hazard model adjusting for age, study center, gender, AJCC disease stage, and MSI tumor status...
November 18, 2016: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/27855586/urolithiasis-in-renal-allografts-complications-and-outcomes
#14
Frank Friedersdorff, Nasrin El-Bandar, Jonas Busch, Barbara Erber, Kurt Miller, Tom Florian Fuller, Robert Peters
OBJECTIVES: Urinary calculi rarely occur in renal transplant. However, because of peculiarities shown with renal allografts, a prudent approach is necessary to prevent further complications or even graft failure. There are no well-established guidelines for uro?ithiasis in renal grafts regarding adequate therapy selection. In the present article, different therapeutic interventions are discussed, including in 1 case a pyelovesicostomy as an uncommon intervention. MATERIALS AND METHODS: We retrospectively reviewed data of 1115 patients who underwent renal transplant between January 2002 and December 2014 for urolithiasis in different databases...
November 18, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27850752/1115-retrospective-study-of-current-practices-of-heparin-induced-thrombocytopenia-diagnosis-and-treatment
#15
Melinda Miller, Farid Sadaka
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27843424/improving-the-collection-of-race-ethnicity-and-language-data-to-reduce-healthcare-disparities-a-case-study-from-an-academic-medical-center
#16
Wei-Chen Lee, Sreenivas P Veeranki, Hani Serag, Karl Eschbach, Kenneth D Smith
Well-designed electronic health records (EHRs) must integrate a variety of accurate information to support efforts to improve quality of care, particularly equity-in-care initiatives. This case study provides insight into the challenges those initiatives may face in collecting accurate race, ethnicity, and language (REAL) information in the EHR. We present the experience of an academic medical center strengthening its EHR for better collection of REAL data with funding from the EHR Incentive Programs for meaningful use of health information technology and the Texas Medicaid 1115 Waiver program...
2016: Perspectives in Health Information Management
https://www.readbyqxmd.com/read/27837444/return-to-work-among-self-employed-cancer-survivors
#17
Steffen Torp, Jonn Syse, Alain Paraponaris, Sævar Gudbergsson
PURPOSE: The aim of this study is to investigate whether salaried and self-employed workers differ regarding factors relevant for return to work after being diagnosed with cancer. The possible mediators of an effect of self-employment on work ability were also investigated. METHODS: A total of 1115 cancer survivors (1027 salaried and 88 self-employed) of common invasive cancer types who were in work at the time of diagnosis completed a mailed questionnaire 15-39 months after diagnosis...
November 12, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27822603/-treatment-costs-of-localized-prostate-cancer-in-germany-economic-results-from-the-harow-observational-study
#18
T Reinhold, C Dornquast, C Börgermann, L Weißbach
BACKGROUND: Prostate cancer (PCa) is the most common cancer in men. For medical treatment of PCa, a number of therapies are available. The economic consequences associated with these individual treatment options in routine care in Germany are unclear so far. METHODS: The present analysis was based on the Germany-wide HAROW observational study, which was conducted from 2008-2013. During this study, all participating physicians and involved patients reported and documented individual health care resource consumption...
December 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27821817/is-there-a-dose-dependent-effect-of-genetic-susceptibility-loci-for-gastric-cancer-on-prognosis-of-the-patients
#19
Lei Cheng, Li-Xin Qiu, Ming Jia, Fei Zhou, Meng-Yun Wang, Ruo-Xin Zhang, Yajun Yang, Xiaofeng Wang, Jiucun Wang, Li Jin, Qing-Yi Wei
Literature suggests that genetic variants associated with increased susceptibility to gastric cancer (GCa) are mostly located in genes involved in carcinogenesis and possibly tumor progression. Therefore, we hypothesize that high genetic susceptibility is also associated with prognosis of the patients. To test this hypothesis, we selected a total of 42 common genetic variants that were reportedly associated with GCa risk with a high level of evidence obtained from either genome-wide association studies (GWASs) or meta-analyses and performed survival analysis of patients used in a case-control analysis...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27820828/pre-transplant-depression-is-associated-with-length-of-hospitalization-discharge-disposition-and-survival-after-liver-transplantation
#20
Shari S Rogal, Gautham Mankaney, Viyan Udawatta, Matthew Chinman, Chester B Good, Susan Zickmund, Klaus Bielefeldt, Alexis Chidi, Naudia Jonassaint, Alison Jazwinski, Obaid Shaikh, Christopher Hughes, Paulo Fontes, Abhinav Humar, Andrea DiMartini
Depression after liver transplantation has been associated with decreased survival, but the effects of pre-transplant depression on early and late post-transplant outcomes remain incompletely evaluated. We assessed all patients who had undergone single-organ liver transplantation at a single center over the prior 10 years. A diagnosis of pre-transplant depression, covariates, and the outcomes of interest were extracted from the electronic medical record. Potential covariates included demographics, etiology and severity of liver disease, comorbidities, donor age, graft type, immunosuppression, and ischemic times...
2016: PloS One
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