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Gout and multiple sclerosis

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https://www.readbyqxmd.com/read/27804015/combined-brain-and-anterior-visual-pathways-mris-assist-in-early-identification-of-neuromyelitis-optica-spectrum-disorder-at-onset-of-optic-neuritis
#1
D Buch, J Savatovsky, O Gout, C Vignal, R Deschamps
Acute optic neuritis (ON) is the initial presentation in half of neuromyelitis optica spectrum disorder (NMO-SD) cases. Our objective was to evaluate accuracy of combined MRIs of the anterior visual pathways and of the brain to correctly identify NMO-SD among patients with acute ON. We performed a retrospective study on patients with acute ON in NMO-SD (16 episodes) and first-event non-NMO-SD (32 episodes). All MRIs included exams of the brain and anterior visual pathways using T2-weighted and post-gadolinium T1-weighted coronal thin slices...
November 1, 2016: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/27650313/the-nlrp3-inflammasome-in-pathogenic-particle-and-fibre-associated-lung-inflammation-and-diseases
#2
REVIEW
Mutlay Sayan, Brooke T Mossman
The concept of the inflammasome, a macromolecular complex sensing cell stress or danger signals and initiating inflammation, was first introduced approximately a decade ago. Priming and activation of these intracellular protein platforms trigger the maturation of pro-inflammatory chemokines and cytokines, most notably, interleukin-1β (IL-1β) and IL-18, to promulgate innate immune defenses. Although classically studied in models of gout, Type II diabetes, Alzheimer's disease, and multiple sclerosis, the importance and mechanisms of action of inflammasome priming and activation have recently been elucidated in cells of the respiratory tract where they modulate the responses to a number of inhaled pathogenic particles and fibres...
September 20, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27589059/md1003-high-dose-biotin-for-the-treatment-of-progressive-multiple-sclerosis-a-randomised-double-blind-placebo-controlled-study
#3
Ayman Tourbah, Christine Lebrun-Frenay, Gilles Edan, Michel Clanet, Caroline Papeix, Sandra Vukusic, Jerome De Sèze, Marc Debouverie, Olivier Gout, Pierre Clavelou, Gilles Defer, David-Axel Laplaud, Thibault Moreau, Pierre Labauge, Bruno Brochet, Frédéric Sedel, Jean Pelletier
BACKGROUND: Treatment with MD1003 (high-dose biotin) showed promising results in progressive multiple sclerosis (MS) in a pilot open-label study. OBJECTIVE: To confirm the efficacy and safety of MD1003 in progressive MS in a double-blind, placebo-controlled study. METHODS: Patients (n = 154) with a baseline Expanded Disability Status Scale (EDSS) score of 4.5-7 and evidence of disease worsening within the previous 2 years were randomised to 12-month MD1003 (100 mg biotin) or placebo thrice daily, followed by 12-month MD1003 for all patients...
November 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27542954/enhanced-alpha-kinase-1-accelerates-multiple-early-nephropathies-in-streptozotocin-induced-hyperglycemic-mice
#4
Tzer-Min Kuo, Hui-Ting Hsu, Chia-Min Chung, Kun-Tu Yeh, Cheng-Tien Wu, Chi-Pin Lee, Shang-Lun Chiang, Chung-Ming Huang, Ying-Chin Ko
Alpha-kinase 1 (ALPK1) is associated with chronic kidney disease (CKD), type 2 diabetes mellitus and gout. Elevated ALPK1 levels have been observed in the kidneys of patients with diabetes and the white blood cells of patients with gout. As renal injury is a common outcome of CKD, diabetes and gout, the aim of this study was to investigate the effect of ALPK1 in the development of renal injury in a hyperglycemic condition. Hyperglycemia was induced in wild-type and ALPK1 transgenic mice by an intraperitoneal injection of streptozotocin (STZ)...
November 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27039371/gwas-and-transcriptional-analysis-prioritize-itpr1-and-cntn4-for-a-serum-uric-acid-3p26-qtl-in-mexican-americans
#5
Geetha Chittoor, Jack W Kent, Marcio Almeida, Sobha Puppala, Vidya S Farook, Shelley A Cole, Karin Haack, Harald H H Göring, Jean W MacCluer, Joanne E Curran, Melanie A Carless, Matthew P Johnson, Eric K Moses, Laura Almasy, Michael C Mahaney, Donna M Lehman, Ravindranath Duggirala, Anthony G Comuzzie, John Blangero, Venkata Saroja Voruganti
BACKGROUND: The variation in serum uric acid concentrations is under significant genetic influence. Elevated SUA concentrations have been linked to increased risk for gout, kidney stones, chronic kidney disease, and cardiovascular disease whereas reduced serum uric acid concentrations have been linked to multiple sclerosis, Parkinson's disease and Alzheimer's disease. Previously, we identified a novel locus on chromosome 3p26 affecting serum uric acid concentrations in Mexican Americans from San Antonio Family Heart Study...
2016: BMC Genomics
https://www.readbyqxmd.com/read/26964539/plasma-exchange-response-in-34-patients-with-severe-optic-neuritis
#6
Romain Deschamps, Antoine Gueguen, Nathalie Parquet, Samir Saheb, Francoise Driss, Malcie Mesnil, Catherine Vignal, Jennifer Aboab, Raphael Depaz, Olivier Gout
Optic neuritis could lead to severe visual impairment despite corticosteroids. Our aim was to evaluate the rate of visual improvement in patients treated with plasma exchange (PLEX) for severe steroid unresponsive optic neuritis and to identify predictive factors of outcome. Thirty-four patients (41 optic nerves damaged) with remaining visual acuity of 0.1 or less despite steroid pulse therapy were treated with PLEX from September 2010 to May 2015. Demographic and clinical neuro-ophthalmic findings, and spectral domain-optical coherence tomography data before PLEX treatment were analyzed...
May 2016: Journal of Neurology
https://www.readbyqxmd.com/read/26826205/comparative-efficacy-of-fingolimod-vs-natalizumab-a-french-multicenter-observational-study
#7
MULTICENTER STUDY
Laetitia Barbin, Chloe Rousseau, Natacha Jousset, Romain Casey, Marc Debouverie, Sandra Vukusic, Jerome De Sèze, David Brassat, Sandrine Wiertlewski, Bruno Brochet, Jean Pelletier, Patrick Vermersch, Gilles Edan, Christine Lebrun-Frenay, Pierre Clavelou, Eric Thouvenot, Jean-Philippe Camdessanché, Ayman Tourbah, Bruno Stankoff, Abdullatif Al Khedr, Philippe Cabre, Caroline Papeix, Eric Berger, Olivier Heinzlef, Thomas Debroucker, Thibault Moreau, Olivier Gout, Bertrand Bourre, Alain Créange, Pierre Labauge, Laurent Magy, Gilles Defer, Yohann Foucher, David A Laplaud
OBJECTIVE: To compare natalizumab and fingolimod on both clinical and MRI outcomes in patients with relapsing-remitting multiple sclerosis (RRMS) from 27 multiple sclerosis centers participating in the French follow-up cohort Observatoire of Multiple Sclerosis. METHODS: Patients with RRMS included in the study were aged from 18 to 65 years with an Expanded Disability Status Scale score of 0-5.5 and an available brain MRI performed within the year before treatment initiation...
February 23, 2016: Neurology
https://www.readbyqxmd.com/read/26683156/ncf1-polymorphism-reveals-oxidative-regulation-of-autoimmune-chronic-inflammation
#8
REVIEW
Rikard Holmdahl, Outi Sareila, Lina M Olsson, Liselotte Bäckdahl, Kajsa Wing
The current review on the function of neutrophil cytosolic factor 1 (NCF1) and induced reactive oxygen species (ROS) is based on a genetic search for the major genes controlling autoimmune inflammatory disorders. Surprisingly, the disease-promoting allele determined a lower ROS response and was therefore in complete contrast to the prevailing dogma. Once cloned, it opened the possibility to dissect this complex field from a new angle and with the possibilities to study the role of ROS in vivo. We found that NCF1 and NADPH oxidase 2 (NOX2) complex-derived ROS is an important regulator of several chronic inflammatory disorders by using models for rheumatoid arthritis, multiple sclerosis, psoriasis and psoriasis arthritis, gout, and lupus...
January 2016: Immunological Reviews
https://www.readbyqxmd.com/read/26338219/combining-billing-codes-clinical-notes-and-medications-from-electronic-health-records-provides-superior-phenotyping-performance
#9
Wei-Qi Wei, Pedro L Teixeira, Huan Mo, Robert M Cronin, Jeremy L Warner, Joshua C Denny
OBJECTIVE: To evaluate the phenotyping performance of three major electronic health record (EHR) components: International Classification of Disease (ICD) diagnosis codes, primary notes, and specific medications. MATERIALS AND METHODS: We conducted the evaluation using de-identified Vanderbilt EHR data. We preselected ten diseases: atrial fibrillation, Alzheimer's disease, breast cancer, gout, human immunodeficiency virus infection, multiple sclerosis, Parkinson's disease, rheumatoid arthritis, and types 1 and 2 diabetes mellitus...
April 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/25884318/clinical-associations-between-gout-and-multiple-sclerosis-parkinson-s-disease-and-motor-neuron-disease-record-linkage-studies
#10
Julia Pakpoor, Olena O Seminog, Sreeram V Ramagopalan, Michael J Goldacre
BACKGROUND: Uric acid has antioxidant effects on neurons. Abnormally high levels of uric acid are, however, associated with gout. Previous studies have suggested that high levels of uric acid (and the presence of gout) may exert a protective effect against the risk of developing some neurological diseases. We aimed to investigate this hypothesis in a large database of hospital admissions in England. METHODS: We analysed a database of linked statistical records of hospital admissions and death registrations in England (1999-2012)...
2015: BMC Neurology
https://www.readbyqxmd.com/read/25787192/high-doses-of-biotin-in-chronic-progressive-multiple-sclerosis-a-pilot-study
#11
Frédéric Sedel, Caroline Papeix, Agnès Bellanger, Valérie Touitou, Christine Lebrun-Frenay, Damien Galanaud, Olivier Gout, Olivier Lyon-Caen, Ayman Tourbah
BACKGROUND: No drug has been found to have any impact on progressive multiple sclerosis (MS). Biotin is a vitamin acting as a coenzyme for carboxylases involved in key steps of energy metabolism and fatty acids synthesis. Among others, biotin activates acetylCoA carboxylase, a potentially rate-limiting enzyme in myelin synthesis. OBJECTIVES: The aim of this pilot study is to assess the clinical efficacy and safety of high doses of biotin in patients suffering from progressive MS...
March 2015: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/25683762/criteria-improving-multiple-sclerosis-diagnosis-at-the-first-mri
#12
Nathalie Caucheteux, Adil Maarouf, Margaux Genevray, Emmanuelle Leray, Romain Deschamps, Marie P Chaunu, Laure Daelman, Jean C Ferré, Olivier Gout, Jean Pelletier, Laurent Pierot, Gilles Edan, Ayman Tourbah
The introduction of the McDonald criteria has enabled earlier diagnosis of multiple sclerosis (MS). However, even with the 2010 revised criteria, nearly 50% of patients remain classified as "possible MS" following the first MRI. The present study aimed to demonstrate that time to MS diagnosis could be shorter than 2010 revised criteria, and established after a single early MRI in most patients with the association of the symptomatic lesion and at least one suggestive asymptomatic lesion. We also evaluated the short-term predictive capacity of an individual suggestive lesion on disease activity...
2015: Journal of Neurology
https://www.readbyqxmd.com/read/25346628/cannabidiol-promise-and-pitfalls
#13
Timothy E Welty, Adrienne Luebke, Barry E Gidal
Over the past few years, increasing public and political pressure has supported legalization of medical marijuana. One of the main thrusts in this effort has related to the treatment of refractory epilepsy-especially in children with Dravet syndrome-using cannabidiol (CBD). Despite initiatives in numerous states to at least legalize possession of CBD oil for treating epilepsy, little published evidence is available to prove or disprove the efficacy and safety of CBD in patients with epilepsy. This review highlights some of the basic science theory behind the use of CBD, summarizes published data on clinical use of CBD for epilepsy, and highlights issues related to the use of currently available CBD products...
September 2014: Epilepsy Currents
https://www.readbyqxmd.com/read/25209423/optimal-design-of-clinical-trials-with-biologics-using-dose-time-response-models
#14
Markus R Lange, Heinz Schmidli
Biologics, in particular monoclonal antibodies, are important therapies in serious diseases such as cancer, psoriasis, multiple sclerosis, or rheumatoid arthritis. While most conventional drugs are given daily, the effect of monoclonal antibodies often lasts for months, and hence, these biologics require less frequent dosing. A good understanding of the time-changing effect of the biologic for different doses is needed to determine both an adequate dose and an appropriate time-interval between doses. Clinical trials provide data to estimate the dose-time-response relationship with semi-mechanistic nonlinear regression models...
December 30, 2014: Statistics in Medicine
https://www.readbyqxmd.com/read/25129839/diurnal-and-twenty-four-hour-patterning-of-human-diseases-acute-and-chronic-common-and-uncommon-medical-conditions
#15
REVIEW
Michael H Smolensky, Francesco Portaluppi, Roberto Manfredini, Ramon C Hermida, Ruana Tiseo, Linda L Sackett-Lundeen, Erhard L Haus
The symptom intensity and mortality of human diseases, conditions, and syndromes exhibit diurnal or 24 h patterning, e.g., skin: atopic dermatitis, urticaria, psoriasis, and palmar hyperhidrosis; gastrointestinal: esophageal reflux, peptic ulcer (including perforation and hemorrhage), cyclic vomiting syndrome, biliary colic, hepatic variceal hemorrhage, and proctalgia fugax; infection: susceptibility, fever, and mortality; neural: frontal, parietal, temporal, and occipital lobe seizures, Parkinson's and Alzheimer's disease, hereditary progressive dystonia, and pain (cancer, post-surgical, diabetic neuropathic and foot ulcer, tooth caries, burning mouth and temporomandibular syndromes, fibromyalgia, sciatica, intervertebral vacuum phenomenon, multiple sclerosis muscle spasm, and migraine, tension, cluster, hypnic, and paroxysmal hemicranial headache); renal: colic and nocturnal enuresis and polyuria; ocular: bulbar conjunctival redness, keratoconjunctivitis sicca, intraocular pressure and anterior ischemic optic neuropathy, and recurrent corneal erosion syndrome; psychiatric/behavioral: major and seasonal affective depressive disorders, bipolar disorder, parasuicide and suicide, dementia-associated agitation, and addictive alcohol, tobacco, and heroin cravings and withdrawal phenomena; plus autoimmune and musculoskeletal: rheumatoid arthritis, osteoarthritis, axial spondylarthritis, gout, Sjögren's syndrome, and systemic lupus erythematosus...
June 2015: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/24987041/swelling-and-pain-2-weeks-after-a-dog-bite
#16
Michael Alexander Lane, Thomas H Taylor
No abstract text is available yet for this article.
July 2014: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/24876183/abnormal-inflammatory-activity-returns-after-natalizumab-cessation-in-multiple-sclerosis
#17
Antoine Gueguen, Pascal Roux, Romain Deschamps, Antoine Moulignier, Caroline Bensa, Julien Savatovsky, Françoise Heran, Olivier Gout
OBJECTIVE: To characterise recurrence of multiple sclerosis (MS) inflammatory activity during the year following natalizumab (NTZ) cessation. METHODS: Thirty-two patients with MS were included in a monocentric cohort study. Data were collected prospectively during and after NTZ, with serial clinical and MRI evaluations. The first relapse occurring after interrupting NTZ was the primary outcome measure. The numbers of gadolinium-enhancing lesions before, during and after NTZ treatment, were compared...
September 2014: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/23764421/-update-on-diagnosis-and-treatment-of-multiple-sclerosis
#18
REVIEW
R Depaz, J Aboab, O Gout
Recent advances in neuroimaging have simplified the diagnostic criteria of multiple sclerosis. Indeed, the diagnosis of multiple sclerosis could be obtained during the first bout of disease flare, very early in the disease course. This is particularly important to shorten the diagnostic delay as early treatment may limit the occurrence of late irreversible disabilities. At the same time, major therapeutic advances have been obtained and new drugs that are well tolerated and more effective, despite the possible rare but potentially severe side effects are been developed...
October 2013: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/23490781/sch%C3%A3-tzt-harns%C3%A3-ure-vor-multipler-sklerose
#19
Mattle, Lienert, Greeve
Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Its etiology is not known, but it is well established that auto-reactive T-cells and monocytes play an important pathogenetic role. Experimental allergic encephalomyelitis (EAE) of mice serves as disease model for MS. In both EAE and MS inflammatory cells produce nitric oxide and its oxidizing congeners such as peroxynitrite. Peroxynitrite and other reactive nitrogen oxide species exert a toxic effect on neurons, axons and glia cells and enhance apoptosis...
September 1, 2004: Therapeutische Umschau. Revue Thérapeutique
https://www.readbyqxmd.com/read/21903562/fda-new-drug-approvals-in-2010
#20
Richard L Wynn
No abstract text is available yet for this article.
July 2011: General Dentistry
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