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Glomerulonephritid

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https://www.readbyqxmd.com/read/27804122/calcineurin-inhibitors-pharmacologic-mechanisms-impacting-both-insulin-resistance-and-insulin-secretion-leading-to-glucose-dysregulation-and-diabetes-mellitus
#1
REVIEW
H A Chakkera, Y Kudva, B Kaplan
Calcineurin inhibitors (CNIs), including tacrolimus and cyclosporine, are immune-modulating agents used in autoimmune disorders, glomerulonephritides, and after transplantation. CNIs are implicated as diabetogenic drugs but the mechanism is not clearly elucidated. Calcineurin is a cytosolic-phosphatase critical for T-lymphocyte activation. Calcineurin is widely distributed in different tissues responsible for glucose-regulation including pancreas, liver, skeletal muscle, adipocytes, brain, and gut. We describe the pharmacologic effects of CNIs in different tissues and impact on glucose regulation...
November 2, 2016: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27767356/etiology-clinical-profile-and-short-term-outcome-of-acute-kidney-injury-in-children-at-a-tertiary-care-pediatric-nephrology-center-in-pakistan
#2
Vina Tresa, Afshan Yaseen, Ali Asghar Lanewala, Seema Hashmi, Sabeeta Khatri, Irshad Ali, Muhammed Mubarak
BACKGROUND: The reported prevalence rates and etiologies of acute kidney injury (AKI) are quite variable in different regions of the world. The current study was planned to determine the etiology, clinical profile, and short-term outcome of pediatric AKI at our hospital. METHODS: A prospective, observational study was carried out from April 2014 to March 2015. All pediatric patients (1 month to ≤15 years) diagnosed as AKI using modified pRIFLE criteria were studied and followed for 3 months to document short-term outcome...
October 21, 2016: Renal Failure
https://www.readbyqxmd.com/read/27384366/glomerular-disease-and-acute-kidney-injury-in-sudan-demographics-histological-diagnosis-and-outcome
#3
El-Hussein E A El-Hassan, Mohamed B Ghalib, Azam I S Ibrahim, Bethan Phillips, Aled Owain Phillips
BACKGROUND: Acute kidney injury (AKI) is a relatively common clinical condition, associated with high rates of mortality. Although there is extensive literature on the nature and consequence of AKI in the developed world, much less is known in the developing world and more specifically in sub-Saharan Africa (SSA). OBJECTIVES: To describe the demographics, histological diagnosis and clinical course of patients presenting with AKI to a single centre in Sudan. METHODS: Retrospective data were collected on 100 consecutive patients with AKI and an active urinary sediment, who underwent diagnostic native percutaneous renal biopsy...
July 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27335377/optimizing-the-translational-value-of-animal-models-of-glomerulonephritis-insights-from-recent-murine-prototypes
#4
REVIEW
Mary H Foster
Animal models are indispensable for the study of glomerulonephritis, a group of diseases that destroy kidneys but for which specific therapies do not yet exist. Novel interventions are urgently needed, but their rational design requires suitable in vivo platforms to identify and test new candidates. Animal models can recreate the complex immunologic microenvironments that foster human autoimmunity and nephritis and provide access to tissue compartments not readily examined in patients. Study of rat Heymann nephritis identified fundamental disease mechanisms that ultimately revolutionized our understanding of human membranous nephropathy...
September 1, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/26975943/mayo-clinic-renal-pathology-society-consensus-classification-of-glomerulonephritides-a-giant-leap-in-right-direction
#5
Muhammed Mubarak
No abstract text is available yet for this article.
March 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/26921911/primary-glomerulonephritides
#6
REVIEW
Jürgen Floege, Kerstin Amann
Most glomerulonephritides, even the more common types, are rare diseases. They are nevertheless important since they frequently affect young people, often cannot be cured, and can lead to chronic kidney disease, including end-stage renal failure, with associated morbidity and cost. For example, in young adults, IgA nephropathy is the most common cause of end-stage renal disease. In this Seminar, we summarise existing knowledge of clinical signs, pathogenesis, prognosis, and treatment of glomerulonephritides, with a particular focus on data published between 2008 and 2015, and the most common European glomerulonephritis types, namely IgA nephropathy, membranous glomerulonephritis, minimal change disease, focal segmental glomerulosclerosis, membranoproliferative glomerulonephritis, and the rare complement-associated glomerulonephritides such as dense deposit disease and C3 glomerulonephritis...
May 14, 2016: Lancet
https://www.readbyqxmd.com/read/26793696/pathophysiology-evaluation-and-management-of-edema-in-childhood-nephrotic-syndrome
#7
REVIEW
Demetrius Ellis
Generalized edema is a major presenting clinical feature of children with nephrotic syndrome (NS) exemplified by such primary conditions as minimal change disease (MCD). In these children with classical NS and marked proteinuria and hypoalbuminemia, the ensuing tendency to hypovolemia triggers compensatory physiological mechanisms, which enhance renal sodium (Na(+)) and water retention; this is known as the "underfill hypothesis." Edema can also occur in secondary forms of NS and several other glomerulonephritides, in which the degree of proteinuria and hypoalbuminemia, are variable...
2015: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/26700440/b-cells-antibodies-and-more
#8
REVIEW
William Hoffman, Fadi G Lakkis, Geetha Chalasani
B cells play a central role in the immunopathogenesis of glomerulonephritides and transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple mechanisms. In addition, B cells contribute to disease pathogenesis in autoimmunity and alloimmunity by presenting antigens as well as providing costimulation and cytokines to T cells. B cells also play an immunomodulatory role in regulating the immune response by secreting cytokines that inhibit disease onset and/or progression. B cell-targeted approaches for treating immune diseases of the kidney and other organs have gained significant momentum...
January 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26588008/long-term-kidney-transplant-outcomes-in-primary-glomerulonephritis-analysis-from-the-era-edta-registry
#9
Maria Pippias, Vianda S Stel, Nuria Aresté-Fosalba, Cécile Couchoud, Gema Fernandez-Fresnedo, Patrik Finne, James G Heaf, Andries Hoitsma, Johan De Meester, Runolfur Pálsson, Pietro Ravani, Mårten Segelmark, Jamie P Traynor, Anna V Reisæter, Fergus J Caskey, Kitty J Jager
BACKGROUND: We evaluated the 15-year kidney allograft survival in patients with primary glomerulonephritis and determined if the risk of graft loss varied with donor source within each glomerulonephritis group. METHODS: Using data from the European Renal Association-European Dialysis and Transplant Association Registry, Kaplan-Meier, competing risk, and Cox regression analyses were performed on adult, first kidney transplant recipients during 1991 to 2010 (n = 14 383)...
September 2016: Transplantation
https://www.readbyqxmd.com/read/26459770/immunology-of-membranous-nephropathy-from-animal-models-to-humans
#10
REVIEW
R A Sinico, N Mezzina, B Trezzi, G M Ghiggeri, A Radice
Membranous nephropathy (MN), the leading cause of nephrotic syndrome in adults, is characterized by the deposition of subepithelial immune deposits that consist mainly of immunoglobulin (Ig)G and complement. Most of the cases are primary or idiopathic (iMN), while only approximately 25% of the cases are secondary to some known disease such as systemic lupus erythematosus, hepatitis B, drugs and malignancies. Most of our knowledge on the pathogenesis of iMN has relied upon old experimental models (i.e. Heymann nephritis) that have shown that immune deposits are formed in situ by the reaction of autoantibodies against the respective podocyte antigen...
February 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/26453615/macrophage-migration-inhibitory-factor-mediates-proliferative-gn-via-cd74
#11
Sonja Djudjaj, Hongqi Lue, Song Rong, Marios Papasotiriou, Barbara M Klinkhammer, Stephanie Zok, Ole Klaener, Gerald S Braun, Maja T Lindenmeyer, Clemens D Cohen, Richard Bucala, Andre P Tittel, Christian Kurts, Marcus J Moeller, Juergen Floege, Tammo Ostendorf, Jürgen Bernhagen, Peter Boor
Pathologic proliferation of mesangial and parietal epithelial cells (PECs) is a hallmark of various glomerulonephritides. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that mediates inflammation by engagement of a receptor complex involving the components CD74, CD44, CXCR2, and CXCR4. The proliferative effects of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44. Herein, we analyzed the effects of local glomerular MIF/CD74/CD44 signaling in proliferative glomerulonephritides...
June 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/26440274/-glomerulonephritides
#12
REVIEW
J Floege
Many forms of glomerulonephritis, even the more common types belong to the so-called rare diseases; however, they are very important, for example with respect to health economics as they often affect young people. An example is immunoglobulin A (IgA) nephropathy, which is the most common cause of end stage renal disease in young adults. This review summarizes the current knowledge on the pathogenesis, clinical presentation and therapy of the most common European types of glomerulonephritis with a special focus on the most recently acquired knowledge on IgA nephropathy, membranous glomerulonephritis, minimal change nephropathy and focal segmental glomerulosclerosis (FSGS)...
November 2015: Der Internist
https://www.readbyqxmd.com/read/26307557/t-helper-th-cytokines-in-the-urine-of-patients-with-primary-glomerulonephritis-treated-with-immunosuppressive-drugs-can-they-predict-outcome
#13
Dimitra Kalavrizioti, Miltiadis Gerolymos, Maria Rodi, Pantelitsa Kalliakmani, Simela Provatopoulou, Theodoros Eleftheriadis, Athanasia Mouzaki, Dimitrios S Goumenos
BACKGROUND: Glomerulonephritides (GNs) represent common causes of chronic kidney disease associated with a wide spectrum of clinical and histological features. Various factors that activate the inflammatory cascade are involved in the development of kidney injury. The aim of this study was to estimate the urinary excretion of pro-inflammatory (IL-2, INF-γ, TNF-α, IL-6, IL-17) and anti-inflammatory (IL-4, IL-10, TGF-β1) cytokines, as well as the chemokine MCP-1 in patients with various types of GN treated by immunosuppressive drugs and to identify any prognostic value of excreted cytokines for future renal function...
December 2015: Cytokine
https://www.readbyqxmd.com/read/26251216/myeloid-cell-mediated-renal-injury-in-rapidly-progressive-glomerulonephritis-depends-upon-spleen-tyrosine-kinase
#14
Jessica Ryan, Frank Y Ma, Yingjie Han, Elyce Ozols, John Kanellis, Greg H Tesch, David J Nikolic-Paterson
Antibody-dependent activation of myeloid cells within the glomerulus plays a central role in rapidly progressive forms of glomerulonephritis. The spleen tyrosine kinase (Syk) is expressed by all leukocytes, except mature T cells, and is required for signalling via the B-cell receptor, Fc receptors, and some integrins. Syk has been proposed as a therapeutic target in glomerulonephritis. However, little is known of Syk activation in human kidney disease, while studies in experimental glomerulonephritis using non-selective Syk inhibitors require validation via conditional gene deletion...
January 2016: Journal of Pathology
https://www.readbyqxmd.com/read/26096749/long-term-outcomes-for-primary-glomerulonephritis-new-zealand-glomerulonephritis-study
#15
Caroline L Chembo, Mark R Marshall, Laurie C Williams, Robert J Walker, Kelvin L Lynn, John Irvine, Helen L Pilmore
AIMS: Due to the paucity of studies focusing on primary glomerulonephritis, the second commonest cause of end-stage-kidney-disease in most of the developed world, we sought to review outcomes of these renal pathologies. METHODS: We reviewed renal outcomes and mortality for primary glomerulonephritis patients enrolled in the New Zealand Glomerulonephritis Study between 1972 and 1983. RESULTS: There were 765 patients with median follow-up of 30 years (range 0...
December 2015: Nephrology
https://www.readbyqxmd.com/read/26040770/biologic-agents-in-the-treatment-of-glomerulonephritides
#16
REVIEW
See Cheng Yeo, Adrian Liew
Current immunosuppression strategies in the treatment of glomerulonephritides remain unsatisfactory, especially in glomerular diseases that are frequently relapsing or are resistant to treatment. Toxicities associated with the use of drugs with non-specific targets for the immune response result in treatment non-compliance, and increase morbidity and mortality in these patients. Advances in our understanding of the immunopathogenesis of glomerulonephritis and the availability of biologics have led to their successful use in the treatment of immune-mediated glomerular diseases...
November 2015: Nephrology
https://www.readbyqxmd.com/read/26016809/the-role-of-micrornas-and-human-epidermal-growth-factor-receptor-2-in-proliferative-lupus-nephritis
#17
Patrícia Costa-Reis, Pierre A Russo, Zhe Zhang, Lucrezia Colonna, Kelly Maurer, Stefania Gallucci, Steffan W Schulz, Adnan N Kiani, Michelle Petri, Kathleen E Sullivan
OBJECTIVE: To understand the roles of microRNAs (miRNAs) in proliferative lupus nephritis (LN). METHODS: A high-throughput analysis of the miRNA pattern of the kidneys of LN patients and controls was performed by molecular digital detection. Urinary miRNAs were measured by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Target gene expression in human mesangial cells was evaluated by arrays and qRT-PCR. Human epidermal growth factor receptor 2 (HER-2) was analyzed by immunohistochemistry in kidney samples from LN patients and in a murine model of lupus...
September 2015: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/25939936/hematologic-characteristics-of-proliferative-glomerulonephritides-with-nonorganized-monoclonal-immunoglobulin-deposits
#18
Gauri Bhutani, Samih H Nasr, Samar M Said, Sanjeev Sethi, Fernando C Fervenza, William G Morice, Paul J Kurtin, Francis K Buadi, David Dingli, Angela Dispenzieri, Morie A Gertz, Martha Q Lacy, Prashant Kapoor, Shaji Kumar, Robert A Kyle, S Vincent Rajkumar, Nelson Leung
OBJECTIVE: To study the hematologic characteristics of proliferative glomerulonephritides (GNs) from nonorganized glomerular monoclonal immunoglobulin (MIg) deposition (MIPG). PATIENTS AND METHODS: The pathology database at Mayo Clinic (Rochester, Minnesota) was used to find patients with MIPG who underwent a kidney biopsy between January 1, 2008, and December 31, 2013. Retrospective medical record review was conducted in the identified cohort (N=60). RESULTS: The median patient age was 56 years (interquartile range, 47-62 years) and the estimated glomerular filtration rate was 36 mL/min/1...
May 2015: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/25881669/micrornas-in-glomerular-diseases-from-pathophysiology-to-potential-treatment-target
#19
REVIEW
Francesco P Schena, Fabio Sallustio, Grazia Serino
miRNAs are regulators of gene expression in diverse biological and pathological courses in life. Their discovery may be considered one of the most important steps in the story of modern biology. miRNAs are packed within exosomes and released by cells for cellular communications; they are present in bodily fluids. Their study opens the way for understanding the pathogenetic mechanisms of many diseases; furthermore, as potential candidate biomarkers, they can be measured in bodily fluids for non-invasive monitoring of disease outcomes...
June 2015: Clinical Science (1979-)
https://www.readbyqxmd.com/read/25715120/correlation-of-disease-activity-in-proliferative-glomerulonephritis-with-glomerular-spleen-tyrosine-kinase-expression
#20
Stephen P McAdoo, Gurjeet Bhangal, Theresa Page, H Terence Cook, Charles D Pusey, Frederick W K Tam
Spleen tyrosine kinase (SYK) is an important component of the intracellular signaling pathway for various immunoreceptors. Inhibition of SYK has shown promise in preclinical models of autoimmune and glomerular disease. However, the description of SYK expression in human renal tissue, which would be desirable ahead of clinical studies, is lacking. Here we conducted immunohistochemical analysis for total and phosphorylated SYK in biopsy specimens from >120 patients with a spectrum of renal pathologies, including thin basement membrane lesion, minimal change disease, membranous nephropathy, IgA nephropathy, lupus nephritis, ANCA-associated glomerulonephritis, antiglomerular basement membrane disease, and acute tubular necrosis...
July 2015: Kidney International
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