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Platelets antimicrobial

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https://www.readbyqxmd.com/read/28415397/surface-modified-bioresorbable-electrospun-scaffolds-for-improving-hemocompatibility-of-vascular-grafts
#1
Pablo C Caracciolo, María Isabel Rial-Hermida, Florencia Montini-Ballarin, Gustavo A Abraham, Angel Concheiro, Carmen Alvarez-Lorenzo
The replacement of small-diameter vessels is one of the main challenges in tissue engineering. Moreover, the surface modification of small-diameter vascular grafts (SDVG) is a key factor in the success of the therapy due to their increased thrombogenicity and infection susceptibility caused by the lack of a functional endothelium. In this work, electrospun scaffolds were prepared from blends of poly(L-lactic acid) (PLLA) and segmented polyurethane (PHD) with a composition designed to perform as SDVG inner layer...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28409633/tunable-nitric-oxide-release-from-s-nitroso-n-acetylpenicillamine-via-catalytic-copper-nanoparticles-for-biomedical-applications
#2
Jitendra Pant, Marcus James Goudie, Sean P Hopkins, Elizabeth J Brisbois, Hitesh Handa
The quest for novel therapies to prevent bacterial infections and blood clots (thrombosis) is of utmost importance in biomedical research due to exponential growth in cases of thrombosis, blood infections, and the emergence of multi-drug resistant strains of bacteria. Endogenous nitric oxide (NO) is a cellular signaling molecule that plays a pivotal role in host immunity against pathogens, prevention of clotting, and regulation of systemic blood pressure among several biological functions. The physiological effect of NO is dose dependent, that necessitates the need of tunable release kinetics which is the objective of this study...
April 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28358890/a-multifunctional-bioactive-material-that-stimulates-osteogenesis-and-promotes-the-vascularization-bone-marrow-stem-cells-and-their-resistance-to-bacterial-infection
#3
Chuang Ma, Qin Wei, Bo Cao, Xinchun Cheng, Juling Tian, Hongwei Pu, Aihemaitijiang Yusufu, Li Cao
The main limitation of tissue engineering lies in the inability to stimulate osteogenesis, angiogenesis of stem cells and broad-spectrum antimicrobial activity. However, the development of multifunctional bioactive materials with these capabilities remains a great challenge. In this study, we prepared mesoporous silica nanoparticles encapsulated with silver nanocrystals (AG-MSN) with uniform sphere size and mesopores. Platelet-derived growth factor BB (PDGF-BB) was effectively loaded in the AG-MSN mesopores (P-AG-MSN)...
2017: PloS One
https://www.readbyqxmd.com/read/28317023/reduction-of-thrombosis-and-bacterial-infection-via-controlled-nitric-oxide-no-release-from-s-nitroso-n-acetylpenicillamine-snap-impregnated-carbosil-intravascular-catheters
#4
Yaqi Wo, Elizabeth J Brisbois, Jianfeng Wu, Zi Li, Terry C Major, Azmath Mohammed, Xianglong Wang, Alessandro Colletta, Joseph L Bull, Adam J Matzger, Chuanwu Xi, Robert H Bartlett, Mark E Meyerhoff
Nitric oxide (NO) has many important physiological functions, including its ability to inhibit platelet activation and serve as potent antimicrobial agent. The multiple roles of NO in vivo have led to great interest in the development of biomaterials that can deliver NO for specific biomedical applications. Herein, we report a simple solvent impregnation technique to incorporate a nontoxic NO donor, S-nitroso-N-acetylpenicillamine (SNAP), into a more biocompatible biomedical grade polymer, CarboSil 20 80A. The resulting polymer-crystal composite material yields a very stable, long-term NO release biomaterial...
March 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28314181/photocatalytic-degradation-effect-of-malachite-green-and-catalytic-hydrogenation-by-uv-illuminated-ceo2-cdo-multilayered-nanoplatelet-arrays-investigation-of-antifungal-and-antimicrobial-activities
#5
C Maria Magdalane, K Kaviyarasu, J Judith Vijaya, C Jayakumar, M Maaza, B Jeyaraj
CeO2/CdO multi-layered nanoplatelet arrays have been synthesized by sol-gel method at two different temperatures using Citrus limonum fruit extract and the effect of particle size on the photocatalytic performance is studied. The particle size and phases was analysed by X-ray diffraction pattern (XRD) which brought out the formation of cubic phase in the synthesized samples. Field Emission Scanning electron microscopy (FESEM) revealed the surface morphology and made up of cumulative form of platelet shaped arrays with an average size of 10nm...
March 9, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28295179/platelets-and-infections-in-the-resource-limited-countries-with-a-focus-on-malaria-and-viral-haemorrhagic-fevers
#6
REVIEW
Jecko Thachil
Infections continue to cause a high incidence of mortality and morbidity in resource-poor nations. Although antimicrobial therapy has aided mostly in dealing with the pathogenic micro-organisms themselves, the collateral damage caused by the infections continue to cause many deaths. Intensive care support and manipulation of the hosts' abnormal response to the infection have helped to improve mortality in well-resourced countries. But, in those areas with limited resources, this is not yet the case and simpler methods of diagnosis and interventions are required...
March 14, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28263081/an-effective-and-potentially-safe-blood-disinfection-protocol-using-tetrapyrrolic-photosensitizers
#7
Lúcia Marciel, Luís Teles, Beatriz Moreira, Mário Pacheco, Leandro Mo Lourenço, Maria Gpms Neves, João Pc Tomé, Maria Af Faustino, Adelaide Almeida
AIM: Conventional disinfection techniques, considered safe for plasma, are usually associated with collateral damages on concentrated platelets and erythrocytes. Alternative methods are required and antimicrobial photodynamic therapy (aPDT) seems promising. In this study the effectiveness of two photosensitizers (PS), a porphyrin and a phthalocyanine, to disinfect blood products was evaluated. RESULTS: The cationic porphyrin was more effective in the photoinactivation of bacteria...
March 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28165702/octadecyl-chains-immobilized-onto-hyaluronic-acid-coatings-by-thiol-ene-click-chemistry-increase-the-surface-antimicrobial-properties-and-prevent-platelet-adhesion-and-activation-to-polyurethane
#8
Helena P Felgueiras, L M Wang, K F Ren, M M Querido, Q Jin, M A Barbosa, J Ji, M C L Martins
Infection and thrombus formation are still the biggest challenges for the success of blood contact medical devices. This work aims the development of an antimicrobial and hemocompatible biomaterial coating through which selective binding of albumin (passivant protein) from the bloodstream is promoted and, thus, adsorption of other proteins responsible for bacterial adhesion and thrombus formation can be prevented. Polyurethane (PU) films were coated with hyaluronic acid, an antifouling agent, that was previously modified with thiol groups (HA-SH), using polydopamine as the binding agent...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28131941/rationally-designed-dual-functional-block-copolymers-for-bottlebrush-like-coatings-in-vitro-and-in-vivo-antimicrobial-antibiofilm-and-antifouling-properties
#9
Qiang Gao, Meng Yu, Yajuan Su, Meihua Xie, Xin Zhao, Peng Li, Peter X Ma
Numerous antimicrobial coatings have been developed for biomedical devices/implants, but few can simultaneously fulfill the requirements for antimicrobial and antifouling ability and biocompatibility. In this study, to develop an antimicrobial and antibiofilm surface coating, diblock amphiphilic molecules with antimicrobial and antifouling segments in a single chain were rationally designed and synthesized. Cationic antimicrobial polypeptides (AMP) were first synthesized by N-carboxyanhydride ring-opening polymerization (NCA-ROP)...
March 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28128893/autoclaving-derived-surface-coating-with-in-vitro-and-in-vivo-antimicrobial-and-antibiofilm-efficacies
#10
Yajuan Su, Zelun Zhi, Qiang Gao, Meihua Xie, Meng Yu, Bo Lei, Peng Li, Peter X Ma
Biomedical device-associated infections which engender severe threat to public health require feasible solutions. In this study, block copolymers consisting of antimicrobial, antifouling, and surface-tethering segments in one molecule are synthesized and grafted on polymeric substrates by a facile plasma/autoclave-assisted method. Hetero-bifunctional polyethylene glycol (PEG) with allyl and tosyl groups (APEG-OTs) is first prepared. PEGs with different molecular weights (1200 and 2400 Da) are employed. Polyhexamethylene guanidine (PHMG) which has excellent broad-spectrum antimicrobial activity and thermal/chemical stability, is conjugated with APEG-OTs to generate the block copolymer (APEG-PHMG)...
January 27, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27976971/thiadiazole-inhibitors-a-patent-review
#11
REVIEW
Kamal M Dawood, Thoraya A Farghaly
Four isomeric structures of thiadiazole motifs have outstanding pharmacological inhibitory applications are reported in this review. Thiadiazole nucleus is present in several biologically active natural products and commercial drugs. Most of thiadiazoles reported herein are emphasized to have broad spectrum of medicinal activities. Areas covered: This review represents the recent inhibitory activities of thiadiazole isomeric scaffolds and their broad-spectrum biological applications published as full texts during 2010-2016 as well as the patents published during 2005-2016...
April 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/27922762/nonchemotherapy-drug-induced-agranulocytosis-in-children-detected-by-a-prospective-pharmacovigilance-program
#12
Nicolás Medrano-Casique, Hoi Y Tong, Alberto M Borobia, Antonio J Carcas, Jesús Frías, Elena Ramírez
OBJECTIVES: A prospective evaluation of nonchemotherapy drug-induced agranulocytosis (DIA) cases, which are infrequent in the pediatric population. We characterize agranulocytosis cases and assess lab test differences between drug- and nondrug-induced agranulocytosis. METHODS: Through our Prospective Pharmacovigilance Program from Laboratory Signals at Hospital we detected pediatric agranulocytosis cases from July 2007 to December 2010. This program estimates the incidence, drug causality, clinical features, outcomes of DIA pediatric cases, and assesses laboratory differences with respect to non-DIA...
October 2016: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/27895175/platelets-mediate-host-defense-against-staphylococcus-aureus-through-direct-bactericidal-activity-and-by-enhancing-macrophage-activities
#13
Ramadan A Ali, Leah M Wuescher, Keith R Dona, Randall G Worth
Platelets are the chief effector cells in hemostasis. However, recent evidence suggests they have multiple roles in host defense against infection. Reports by us and others showed that platelets functionally contribute to protection against Staphylococcus aureus infection. In the current study, the capacity of mouse platelets to participate in host defense against S. aureus infection was determined by assessing two possibilities. First, we determined the ability of platelets to kill S. aureus directly; and, second, we tested the possibility that platelets enhance macrophage phagocytosis and intracellular killing of S...
January 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27822369/short-term-effect-of-supplemental-yeast-extract-without-or-with-feed-enzymes-on-growth-performance-immune-status-and-gut-structure-of-weaned-pigs-challenged-with-escherichia-coli-lipopolysaccharide
#14
Samuel M Waititu, Fugui Yin, Rob Patterson, Juan C Rodriguez-Lecompte, Charles M Nyachoti
BACKGROUND: This study investigated the response of piglets receiving a yeast extract without or with a multi-enzyme mixture compared with an antimicrobial growth promoter (AGP) on performance, immune status and gut structure after an E. coli lipopolysaccharide (LPS) challenge. Thirty-six pigs were allotted to six treatments including: a non-challenged control (NCC); LPS-challenged control (CC); CC + AGP; CC + yeast extract; CC + enzymes; and CC + enzymes + yeast extract...
2016: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/27803456/linezolid-induced-thrombocytopenia-is-caused-by-suppression-of-platelet-production-via-phosphorylation-of-myosin-light-chain-2
#15
Masataka Tajima, Yoshinori Kato, Jun Matsumoto, Iori Hirosawa, Mariko Suzuki, Yuki Takashio, Mao Yamamoto, Yoshifumi Nishi, Harumi Yamada
Linezolid (LZD) is an antimicrobial that is commonly used for treatment of vancomycin-resistant Enterococci and methicillin-resistant Staphylococcus aureus infections. However, the development of thrombocytopenia, one of the most frequent adverse side effects of this antimicrobial, can lead to discontinuation of LZD treatment. While clinical studies indicate that risk factors for the development of LZD-induced thrombocytopenia include treatment for >14 consecutive days, renal dysfunction, and chronic liver disease, the fundamental mechanism governing the pathogenesis of this disorder remains unclear...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27802906/platelet-mediated-modulation-of-adaptive-immunity
#16
REVIEW
Matteo Iannacone
Besides being the main cellular effectors of hemostasis, platelets possess a plethora of intracellular mediators (e.g. cytokines, chemokines and antimicrobial molecules) as well as surface receptors (e.g. P-selectin, integrins, CD40L, intercellular adhesion molecule [ICAM]-2, junctional adhesion molecule [JAM]-A, CD44, Toll-like receptors, chemokine receptors) known for their involvement in inflammatory and immune responses. These aspects of platelet biology, which suggest an evolutionary link to a more primitive multifunctional innate defensive cell, position platelets at the interface between coagulation and immunity...
December 2016: Seminars in Immunology
https://www.readbyqxmd.com/read/27795831/impact-of-switching-from-intravenous-to-oral-linezolid-therapy-in-japanese-patients-a-retrospective-cohort-study
#17
Akihiro Tanaka, Akiko Yano, Shinichi Watanabe, Mamoru Tanaka, Hiroaki Araki
BACKGROUND: High oral bioavailability of antimicrobial agents can result in the replacement of intravenous (IV) therapy with oral therapy when a patient meets defined clinical criteria. However, few studies have evaluated the effects of switching antibiotic administration route in Japan, especially for linezolid. This study evaluated an IV-to-oral antibiotic switching program for linezolid treatment at a university hospital in Japan. METHODS: In a retrospective cohort study of 73 patients, we assessed the efficacy and safety of IV-to-oral linezolid therapy (n = 21 patients) compared with IV therapy alone (n = 52 patients)...
2016: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/27792313/multifunctional-mesoporous-carbon-capsules-and-their-robust-coatings-for-encapsulation-of-actives-antimicrobial-and-anti-bioadhesion-functions
#18
Gargi Mishra, Nitesh Mittal, Ashutosh Sharma
We present the synthesis and applications of multifunctional hollow porous carbon spheres with well-ordered pore architecture and ability to encapsulate functional nanoparticles. In the present work, the applications of hollow mesoporous carbon capsules (HMCCs) are illustrated in two different contexts. In the first approach, the hollow capsule core is used to encapsulate silver nanoparticles to impart antimicrobial characteristics. It is shown that silver-loaded HMCCs (concentration ∼100 μg/mL) inhibit the growth and multiplication of bacterial colonies of Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) up to 96% and 83%, respectively...
October 28, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27774337/a-new-proof-of-concept-in-bacterial-reduction-antimicrobial-action-of-violet-blue-light-405%C3%A2-nm-in-ex-vivo-stored-plasma
#19
Michelle Maclean, John G Anderson, Scott J MacGregor, Tracy White, Chintamani D Atreya
Bacterial contamination of injectable stored biological fluids such as blood plasma and platelet concentrates preserved in plasma at room temperature is a major health risk. Current pathogen reduction technologies (PRT) rely on the use of chemicals and/or ultraviolet light, which affects product quality and can be associated with adverse events in recipients. 405 nm violet-blue light is antibacterial without the use of photosensitizers and can be applied at levels safe for human exposure, making it of potential interest for decontamination of biological fluids such as plasma...
2016: Journal of Blood Transfusion
https://www.readbyqxmd.com/read/27771742/pre-engraftment-bloodstream-infections-in-acute-leukemia-patients-undergoing-unrelated-cord-blood-transplantation-following-intensified-myeloablative-conditioning-without-atg
#20
Changcheng Zheng, Baolin Tang, Xiaoyu Zhu, Xuhan Zhang, Lei Zhang, Liangquan Geng, Huilan Liu, Zimin Sun
The aim of this study is to investigate the impact of pre-engraftment bloodstream infections (BSIs) on the outcomes in acute leukemia patients undergoing myeloablative cord blood transplantation (CBT). A total of 226 acute leukemia patients who received unrelated CBT were enrolled in this study, and all these patients received an intensified myeloablative conditioning without ATG. Pre-engraftment BSIs occurred in 72 patients (31.9 %), and the median time of onset was 4.5 days after cord blood infusion, BSIs of gram-negative bacilli, and gram-positive cocci comprised of 63...
January 2017: Annals of Hematology
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