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https://www.readbyqxmd.com/read/28708371/exploring-new-mechanisms-for-effective-antimicrobial-materials-electric-contact-killing-based-on-multiple-schottky-barriers
#1
Eva De Lucas-Gil, Julián Jiménez Reinosa, Kerstin Neuhaus, Liliana Vera, Marisol S Martin-Gonzalez, Jose F Fernandez, Fernando Rubio-Marcos
The increasing threat of multidrug-resistance organisms is a cause for worldwide concern. Progressively microorganisms become resistant to commonly used antibiotics, which are a healthcare challenge. Thus, the discovery of new antimicrobial agents or new mechanisms different from those used is necessary. Here, we report an effective and selective antimicrobial activity of microstructured ZnO (Ms-ZnO) agent through the design of a novel star-shaped morphology, resulting in modulation of surface charge orientation...
July 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28689228/impact-of-a-rapid-molecular-test-for-positive-blood-cultures-from-neonatal-intensive-care-patients-on-clinical-management-a-retrospective-audit
#2
L L Koh, S O'Rourke, M Brennan, L Clooney, M Cafferkey, N McCallion, R J Drew
BACKGROUND: Both Staphylococcus aureus and coagulase negative Staphylococci are common causes of late-onset neonatal sepsis in the neonatal intensive care unit (NICU), usually relating to intravascular access device infections. AIMS: This project aimed to review the impact on antimicrobial treatment and clinical outcome in the NICU setting, of the introduction of the Xpert MRSA/SA BC test (Cepheid, USA) for the identification of staphylococci in blood cultures. METHODS: A retrospective audit was carried out of the pre- and post-intervention periods; the intervention was the introduction of the Xpert MRSA/SA BC test...
July 8, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28686663/in-vitro-release-pharmacokinetics-of-amikacin-teicoplanin-and-polyhexanide-in-a-platelet-rich-fibrin-layer-prf-a-laboratory-evaluation-of-a-modern-autologous-wound-treatment
#3
Daniela Knafl, Florian Thalhammer, Matthias G Vossen
OBJECTIVES: Platelet rich fibrin (PRF) is an autologous fibrin glue, produced from patients' blood, which, besides intraoperative use, has applications in the treatment of infected wounds. The combination with antimicrobial agents results in a prolonged antibacterial effect allowing for wound dressing change intervals of seven days even in infected wounds. The aim of this study was to evaluate release kinetics of amikacin, teicoplanin or polyhexanide from a PRF-layer. METHODS: PRF mixed with teicoplanin, amikacin or polyhexanide was sprayed on a silicon gauze patch and put on a colombia agar with bacteria with known minimal inhibitory concentration (MIC) and incubated for 24 hours and afterwards transferred to another agar with the same bacterial strain...
2017: PloS One
https://www.readbyqxmd.com/read/28681651/the-contribution-of-leucocytes-to-the-antimicrobial-activity-of-platelet-rich-plasma-preparations-a-systematic-review
#4
Federica D'asta, Fenella Halstead, Paul Harrison, Sandra Zecchi Orlandini, Naiem Moiemen, Janet Lord
The infection of a wound is one of the major contributors to delays in healing and tissue regeneration. As multi-drug resistance to antibiotics is becoming a serious threat, research in this field has focused on finding new agents and strategies to fight infection and additionally to reduce healing times. The topical use of autologous Platelet Rich Plasma (PRP) as a biological accelerator of the healing process, has been safely used as a form of treatment for wounds since the 1990s. Although the presence or absence of leucocytes in PRP preparation was previously neglected, in the last decade more attention has been paid to their role and several studies have been conducted to explore both their immuno-metabolic effects and their antimicrobial properties...
July 6, 2017: Platelets
https://www.readbyqxmd.com/read/28643535/efficacy-of-platelets-in-bone-healing-a-systematic-review-on-animal-studies
#5
Sabrina Marcazzan, Roberto Lodovico Weinstein, Massimo Del Fabbro
In presence of large bone defects, delayed bone union, non-union, fractures, and implant surgery, bone reconstruction may be necessary. Different strategies have been employed to enhance bone healing among which the use of autologous platelet concentrates. Due to the high content of platelets and platelet-derived bioactive molecules (e.g., growth factors, antimicrobial peptides), they are promising candidates to increase bone healing. However, a high heterogeneity of both preclinical and clinical studies resulted in contrasting results...
June 23, 2017: Platelets
https://www.readbyqxmd.com/read/28625251/-a-novel-protein-peptide-associated-with-ischemic-heart-disease-dermcidin
#6
Hu Xia, Kai Feng
Dermcidin (DCD) was found in isolated human skin sweat glands with antimicrobial effect, and was defined as a kind of new small molecule antimicrobial peptide. It was a part of human sweat glands in the skin as the immune system's innate defense. With the studies of DCD, its extensive biological functions are gradually discovered. Since 2010, a number of studies have shown that DCD may be a new risk factor for atherosclerosis. And the role of DCD in ischemic heart disease has drawn increasing attention in particular its relationship with insulin secretion and glycemic control, nitric oxide (NO) synthesis and hypertension, platelet aggregation and acute myocardial infarction (AMI)...
June 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28557441/tyrosinase-mediated-surface-coimmobilization-of-heparin-and-silver-nanoparticles-for-antithrombotic-and-antimicrobial-activities
#7
Phuong Le Thi, Yunki Lee, Ho Joon Kwon, Kyung Min Park, Mi Hee Lee, Jong-Chul Park, Ki Dong Park
Thrombus and infections are the most common causes for the failure of medical devices, leading to higher hospitalization costs and, in some cases, patient morbidity. It is, therefore, necessary to develop novel strategies to prevent thrombosis and infection caused by medical devices. Herein, we report a simple and a highly efficient strategy to impart antithrombotic and antimicrobial properties to substrates, by simultaneously immobilizing heparin and in situ-synthesized silver nanoparticles (Ag NPs) via a tyrosinase-catalyzed reaction...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28552640/platelet-released-growth-factors-induce-psoriasin-in-keratinocytes-implications-for-the-cutaneous-barrier
#8
Andreas Bayer, Justus Lammel, Sebastian Lippross, Tim Klüter, Peter Behrendt, Mersedeh Tohidnezhad, Thomas Pufe, Jochen Cremer, Holger Jahr, Franziska Rademacher, Regine Gläser, Jürgen Harder
Millions of patients around the world suffer minor or major extremity amputation due to progressive wound healing complications of chronic or infected wounds, the therapy of which remains a challenge. One emerging therapeutic option for the treatment of these complicated wounds is the local application of an autologous thrombocytes concentrate lysate (e.g. platelet-released growth factors ((PRGF)) or Vivostat PRF(®)) that contains a multitude of chemokines, cytokines and growth factors and is therefore supposed to stimulate the complex wound healing process...
May 25, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28548818/pla-pbat-bionanocomposites-with-antimicrobial-natural-rosin-for-green-packaging
#9
Hesham Moustafa, Nadia El Kissi, Ahmed I Abou-Kandil, Mohamed S Abdel-Aziz, Alain Dufresne
The use of biodegradable polymers is of great importance nowadays in many applications. Some of the most commonly used biopolymers are polylactic acid (PLA) and poly(butylene adipate-co-terephthalate) (PBAT) due to their superior properties and availability. In this manuscript, we use a facile and green modification method of organoclay (OC) by antimicrobial natural rosin which is considered as a toxicity-free reinforcing material, thus keeping the green character of the material. It increases the interlayer spacing between the clay platelets...
June 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28494777/platelet-desialylation-is-a-novel-mechanism-and-a-therapeutic-target-in-thrombocytopenia-during-sepsis-an-open-label-multicenter-randomized-controlled-trial
#10
Mei-Feng Li, Xiao-Li Li, Kai-Liang Fan, Ying-Yi Yu, Jing Gong, Shu-Ying Geng, Ya-Feng Liang, Ling Huang, Ji-Hua Qiu, Xing-Han Tian, Wen-Ting Wang, Xiao-Lu Zhang, Qing-Xia Yu, Yuan-Feng Zhang, Peng Lin, Li-Na Wang, Xin Li, Ming Hou, Lu-Yi Liu, Jun Peng
BACKGROUND: Studies in murine models suggested that platelet desialylation was an important mechanism of thrombocytopenia during sepsis. METHODS: First, we performed a prospective, multicenter, observational study that enrolled septic patients with or without thrombocytopenia to determine the association between platelet desialylation and thrombocytopenia in patients with sepsis, severe sepsis, and septic shock. Gender- and age-matched healthy adults were selected as normal controls in analysis of the platelet desialylation levels (study I)...
May 11, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28470446/drug-loaded-microbeads-entrapped-electrospun-mat-for-wound-dressing-application
#11
P Sneha Sundaran, Aswathy Bhaskaran, Sherrin T Alex, Tilak Prasad, V H Haritha, Y Anie, T V Kumary, P R Anil Kumar
A new design of antibiotic loaded wound dressing and its initial in vitro evaluation is described. Chitosan microbeads loaded with ampicillin were sandwiched within polycaprolactone electrospun mat (MbAPPCL). The morphology was analyzed by scanning electron microscopy and surface chemistry was characterized by Fourier Transform Infrared Spectroscopy. In vitro cytotoxicity using L-929 fibroblast cells by direct contact test and elution assay revealed non-cytotoxic nature of MbAPPCL. The cell adhesion and viability analysis further confirmed the cytocompatibility of MbAPPCL as a wound dressing material...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28454850/procalcitonin-for-the-early-diagnosis-of-sepsis-in-burn-patients-a-retrospective-study
#12
Luís Cabral, Vera Afreixo, Filipe Santos, Luís Almeida, José Artur Paiva
BACKGROUND: The gold standard for sepsis diagnosis in burn patient still relies on microbiological cultures, which take 48-72h to provide results, delaying the start of antimicrobial therapy. Thus, biomarkers allowing an earlier sepsis diagnosis in burn patients are needed. METHODS: This retrospective observational study included 150 burn patients with total burned surface area ≥15%. Clinical diagnosis of sepsis among these patients was done according to the American Burn Association criteria...
April 25, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28442446/proteomic-and-transcriptomic-analysis-of-saliva-components-from-the-hematophagous-reduviid-triatoma-pallidipennis
#13
María J Hernández-Vargas, Jeovanis Gil, Luis Lozano, Martha Pedraza-Escalona, Ernesto Ortiz, Sergio Encarnación-Guevara, Alejandro Alagón, Gerardo Corzo
Species belonging to the Triatominae subfamily are commonly associated with Chagas disease, as they are potential vectors of the parasite Trypanosoma cruzi. However, their saliva contains a cocktail of diverse anti-hemostatic proteins that prevent blood coagulation, vasodilation and platelet aggregation of blood; components with indisputable therapeutic potential. We performed a transcriptomic and proteomic analyses of salivary glands and protein spots from 2DE gels of milked saliva, respectively, from the Mexican Triatoma pallidipennis...
April 22, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28415397/surface-modified-bioresorbable-electrospun-scaffolds-for-improving-hemocompatibility-of-vascular-grafts
#14
Pablo C Caracciolo, María Isabel Rial-Hermida, Florencia Montini-Ballarin, Gustavo A Abraham, Angel Concheiro, Carmen Alvarez-Lorenzo
The replacement of small-diameter vessels is one of the main challenges in tissue engineering. Moreover, the surface modification of small-diameter vascular grafts (SDVG) is a key factor in the success of the therapy due to their increased thrombogenicity and infection susceptibility caused by the lack of a functional endothelium. In this work, electrospun scaffolds were prepared from blends of poly(L-lactic acid) (PLLA) and segmented polyurethane (PHD) with a composition designed to perform as SDVG inner layer...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28409633/tunable-nitric-oxide-release-from-s-nitroso-n-acetylpenicillamine-via-catalytic-copper-nanoparticles-for-biomedical-applications
#15
Jitendra Pant, Marcus J Goudie, Sean P Hopkins, Elizabeth J Brisbois, Hitesh Handa
The quest for novel therapies to prevent bacterial infections and blood clots (thrombosis) is of utmost importance in biomedical research due to the exponential growth in the cases of thrombosis and blood infections and the emergence of multi-drug-resistant strains of bacteria. Endogenous nitric oxide (NO) is a cellular signaling molecule that plays a pivotal role in host immunity against pathogens, prevention of clotting, and regulation of systemic blood pressure, among several other biological functions. The physiological effect of NO is dose dependent, which necessitates the study of its tunable release kinetics, which is the objective of this study...
April 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28358890/a-multifunctional-bioactive-material-that-stimulates-osteogenesis-and-promotes-the-vascularization-bone-marrow-stem-cells-and-their-resistance-to-bacterial-infection
#16
Chuang Ma, Qin Wei, Bo Cao, Xinchun Cheng, Juling Tian, Hongwei Pu, Aihemaitijiang Yusufu, Li Cao
The main limitation of tissue engineering lies in the inability to stimulate osteogenesis, angiogenesis of stem cells and broad-spectrum antimicrobial activity. However, the development of multifunctional bioactive materials with these capabilities remains a great challenge. In this study, we prepared mesoporous silica nanoparticles encapsulated with silver nanocrystals (AG-MSN) with uniform sphere size and mesopores. Platelet-derived growth factor BB (PDGF-BB) was effectively loaded in the AG-MSN mesopores (P-AG-MSN)...
2017: PloS One
https://www.readbyqxmd.com/read/28317023/reduction-of-thrombosis-and-bacterial-infection-via-controlled-nitric-oxide-no-release-from-s-nitroso-n-acetylpenicillamine-snap-impregnated-carbosil-intravascular-catheters
#17
Yaqi Wo, Elizabeth J Brisbois, Jianfeng Wu, Zi Li, Terry C Major, Azmath Mohammed, Xianglong Wang, Alessandro Colletta, Joseph L Bull, Adam J Matzger, Chuanwu Xi, Robert H Bartlett, Mark E Meyerhoff
Nitric oxide (NO) has many important physiological functions, including its ability to inhibit platelet activation and serve as potent antimicrobial agent. The multiple roles of NO in vivo have led to great interest in the development of biomaterials that can deliver NO for specific biomedical applications. Herein, we report a simple solvent impregnation technique to incorporate a nontoxic NO donor, S-nitroso-N-acetylpenicillamine (SNAP), into a more biocompatible biomedical grade polymer, CarboSil 20 80A. The resulting polymer-crystal composite material yields a very stable, long-term NO release biomaterial...
March 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28314181/photocatalytic-degradation-effect-of-malachite-green-and-catalytic-hydrogenation-by-uv-illuminated-ceo2-cdo-multilayered-nanoplatelet-arrays-investigation-of-antifungal-and-antimicrobial-activities
#18
C Maria Magdalane, K Kaviyarasu, J Judith Vijaya, C Jayakumar, M Maaza, B Jeyaraj
CeO2/CdO multi-layered nanoplatelet arrays have been synthesized by sol-gel method at two different temperatures using Citrus limonum fruit extract and the effect of particle size on the photocatalytic performance is studied. The particle size and phases was analysed by X-ray diffraction pattern (XRD) which brought out the formation of cubic phase in the synthesized samples. Field Emission Scanning electron microscopy (FESEM) revealed the surface morphology and made up of cumulative form of platelet shaped arrays with an average size of 10nm...
April 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28295179/platelets-and-infections-in-the-resource-limited-countries-with-a-focus-on-malaria-and-viral-haemorrhagic-fevers
#19
REVIEW
Jecko Thachil
Infections continue to cause a high incidence of mortality and morbidity in resource-poor nations. Although antimicrobial therapy has aided mostly in dealing with the pathogenic micro-organisms themselves, the collateral damage caused by the infections continue to cause many deaths. Intensive care support and manipulation of the hosts' abnormal response to the infection have helped to improve mortality in well-resourced countries. But, in those areas with limited resources, this is not yet the case and simpler methods of diagnosis and interventions are required...
June 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28263081/an-effective-and-potentially-safe-blood-disinfection-protocol-using-tetrapyrrolic-photosensitizers
#20
Lúcia Marciel, Luís Teles, Beatriz Moreira, Mário Pacheco, Leandro Mo Lourenço, Maria Gpms Neves, João Pc Tomé, Maria Af Faustino, Adelaide Almeida
AIM: Conventional disinfection techniques, considered safe for plasma, are usually associated with collateral damages on concentrated platelets and erythrocytes. Alternative methods are required and antimicrobial photodynamic therapy (aPDT) seems promising. In this study the effectiveness of two photosensitizers (PS), a porphyrin and a phthalocyanine, to disinfect blood products was evaluated. RESULTS: The cationic porphyrin was more effective in the photoinactivation of bacteria...
March 2017: Future Medicinal Chemistry
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