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TGF-beta AND supplement

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https://www.readbyqxmd.com/read/29684602/trans-cinnamic-acid-application-for-rainbow-trout-oncorhynchus-mykiss-i-effects-on-haematological-serum-biochemical-non-specific-immune-and-head-kidney-gene-expression-responses
#1
Sevdan Yilmaz, Sebahattin Ergün
The present study investigated the effects of dietary trans-cinnamic acid (CA) on pre- and post-challenge haematological, serum biochemical, non-specific immune and head kidney gene expression responses of rainbow trout, Oncorhynchus mykiss juveniles. In this regard, fish with an average weight of 17.01 ± 0.05 g were divided into five groups, and fed daily with an additive free basal diet (control); 250, 500, 750 or 1500 mg kg-1  CA for a 60-day period. Fish were sampled every 20 days during the experiment...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29659876/effects-of-lactobacillus-reuteri-lr1-on-the-growth-performance-intestinal-morphology-and-intestinal-barrier-function-in-weaned-pigs
#2
Hongbo Yi, Guangda Yang, Yunxia Xiong, Xiaolu Wen, Zhilin Wang, Xuefen Yang, Kaiguo Gao, Li Wang, Zongyong Jiang
The objective of this study was to investigate the effects of Lactobacillus reuteri LR1, a new strain isolated from the feces of weaned pigs, on the growth performance, intestinal morphology, immune responses, and intestinal barrier function in weaned pigs. A total of 144 weaned pigs (Duroc × Landrace × Yorkshire, 21 d of age) with an initial BW of 6.49 ± 0.02 kg were randomly assigned to 3 dietary treatments with 8 replicate pens, each of per treatment and 6 pigs. Pigs were fed a basal diet (CON, controls), the basal diet supplemented with 100 mg/kg olaquindox and 75 mg/kg aureomycin (OA) or the basal diet supplemented with 5×1010 cfu/kg L...
April 12, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29575491/optimization-of-reprogramming-culture-condition-for-the-generation-of-induced-pluripotent-stem-cells-from-col1a1-4f2a-oct4-gfp-mice-with-high-efficiency
#3
Po-Ying Lin, Sheng-Chieh Hsu, Hung-Chi Chen, Wen-Bin Len, Fang-Chi Hsiao, Mei-Chun Liu, Pei-Ling Pan, Tsai-Chen Lin, Ying-Hsuan Lee, Yaa-Jyuhn James Meir
A reprogrammable transgenic mouse strain, called Col1a1 4F2A-Oct4-GFP, was bred for the present study. Because the somatic cells of this mouse strain contain only two copies of each Yamanaka factor, these animals are inefficient at producing iPSCs (approx. 0.005%) under traditional culture conditions. With an optimized culture condition, the iPSC production rate of MEFC ol1a1 4F2A-Oct4- GFP was increased approximately to 8%. Further, promotion of cell proliferation by serum supplementation did not enhance iPSC production...
March 25, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29568314/platelet-lysate-induces-chondrogenic-differentiation-of-umbilical-cord-derived-mesenchymal-stem-cells
#4
Ghmkin Hassan, Mohammad Bahjat, Issam Kasem, Chadi Soukkarieh, Majd Aljamali
Purpose: Articular cartilage has a poor capacity for self-repair, and thus still presents a major challenge in orthopedics. Mesenchymal stem cells (MSCs) are multipotent stem cells with the potential to differentiate into chondrocytes in the presence of transforming growth factor beta (TGF-β). Platelet lysate (PL) contains a relatively large number of growth factors, including TGF-β, and has been shown to ameliorate cartilage repair. Here, we investigated the ability of PL to direct chondrogenic differentiation of MSCs along with other standard differentiation components in a pellet culture system...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29540180/comparison-of-human-bone-marrow-stromal-cells-cultured-in-human-platelet-growth-factors-and-fetal-bovine-serum
#5
Jiaqiang Ren, Dawn Ward, Steven Chen, Katherine Tran, Ping Jin, Marianna Sabatino, Pamela G Robey, David F Stroncek
BACKGROUND: Bone marrow stromal cells (BMSCs) have classically been cultured in media supplemented with fetal bovine serum (FBS). As an alternative to FBS, pooled solvent detergent apheresis platelets, HPGF-C18, was evaluated for BMSC culture. METHODS: A comparison of passage 2 BMSC growth revealed that 10% HPGF-C18 produced similar cell numbers as 20% FBS. Marrow aspirates from 5 healthy subjects were cultured for 4 passages in 10% HPGF-C18 or 20% FBS and were analyzed for proliferation, colony formation efficiency (CFE), surface marker expression, suppression of mixed lymphocyte reactions (MLRs), global gene and microRNA expression analysis...
March 14, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29456507/the-effects-of-vitamin-d-supplementation-on-signaling-pathway-of-inflammation-and-oxidative-stress-in-diabetic-hemodialysis-a-randomized-double-blind-placebo-controlled-trial
#6
Hamed Haddad Kashani, Elahe Seyed Hosseini, Hossein Nikzad, Alireza Soleimani, Maryam Soleimani, Mohammad Reza Tamadon, Fariba Keneshlou, Zatollah Asemi
Objective: This study was carried out to determine the effects of vitamin D supplementation on signaling pathway of inflammation and oxidative stress in diabetic hemodialysis (HD) patients. Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 60 diabetic HD patients. Subjects were randomly allocated into two groups to intake either vitamin D supplements at a dosage of 50,000 IU ( n = 30) or placebo ( n = 30) every 2 weeks for 12 weeks. Gene expression of inflammatory cytokines and biomarkers of oxidative stress were assessed in peripheral blood mononuclear cells (PBMCs) of diabetic HD patients with RT-PCR method...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29420022/transcriptomics-related-mechanisms-of-supplementing-laying-broiler-breeder-hens-with-dietary-daidzein-to-improve-the-immune-function-and-growth-performance-of-offspring
#7
Hao Fan, Zengpeng Lv, Liping Gan, Yuming Guo
Daidzein (DA) is an isoflavone that is primarily extracted from soy plants. This study evaluated the effects of supplementing laying broiler breeder hens with dietary DA on the immune function and growth performance of their offspring and the underlying mechanism. A total of 720 breeders were divided into three treatment groups that were fed either a control diet (CON), a DA-low-supplemented diet (DLS, CON+20 mg/kg DA), or a DA-high-supplemented diet (DHS, CON+100 mg/kg DA) for 8 weeks, and eggs were collected for hatching during the final week...
February 28, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29359480/the-effects-of-fish-oil-on-gene-expression-in-patients-with-polycystic-ovary-syndrome
#8
Elham Rahmani, Mehri Jamilian, Bahareh Dadpour, Zahra Nezami, Zahra Vahedpoor, Samaneh Mahmoodi, Esmat Aghadavod, Mohsen Taghizadeh, Abolfazl Beiki Hassan, Zatollah Asemi
BACKGROUND: This study was conducted to determine the effects of fish oil administration on gene expression related to insulin, lipid and inflammation in women with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled trial was conducted among 40 subjects with PCOS, aged 18-40 years. Subjects were randomly allocated into two groups to take either 1000 mg omega-3 fatty acids from fish oil (n = 20) or placebo (n = 20) twice a day for 12 weeks...
March 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29306057/the-effects-of-omega-3-and-vitamin-e-co-supplementation-on-parameters-of-mental-health-and-gene-expression-related-to-insulin-and-inflammation-in-subjects-with-polycystic-ovary-syndrome
#9
Mehri Jamilian, Azadeh Shojaei, Mansooreh Samimi, Faraneh Afshar Ebrahimi, Esmat Aghadavod, Maryam Karamali, Mohsen Taghizadeh, Hamidreza Jamilian, Somayeh Alaeinasab, Sadegh Jafarnejad, Zatollah Asemi
OBJECTIVE: The aim of this study was to evaluate the effects of omega-3 and vitamin E co-supplementation on parameters of mental health and gene expression related to insulin and inflammation in subjects with polycystic ovary syndrome (PCOS). METHODS: Forty PCOS women were allocated into two groups and treated with 1000mg omega-3 fatty acids plus 400 IU vitamin E supplements (n = 20) or placebo (n = 20) per day for 12 weeks. Parameters of mental health were recorded at baseline and after the 12-week intervention...
March 15, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28945296/prognostic-biomarkers-in-patients-with-human-immunodeficiency-virus-positive-disease-with-head-and-neck-squamous-cell-carcinoma
#10
Hongzheng Zhang, Sungjin Kim, Zhengjia Chen, Sreenivas Nannapaneni, Amy Y Chen, Charles E Moore, Gabriel Sica, Marina Mosunjac, Minh Ly T Nguyen, Gypsyamber D'Souza, Thomas E Carey, Lisa A Peterson, Jonathan B McHugh, Martin Graham, Christine M Komarck, Gregory T Wolf, Heather M Walline, Emily Bellile, James Riddell, Sara I Pai, David Sidransky, William H Westra, William N William, J Jack Lee, Adel K El-Naggar, Robert L Ferris, Raja Seethala, Jennifer R Grandis, Zhuo Georgia Chen, Nabil F Saba, Dong M Shin
BACKGROUND: We examined the prognostic value of a panel of biomarkers in patients with squamous cell carcinoma of the head and neck (SCCHN) who were human immunodeficiency virus (HIV) positive (HIV-positive head and neck cancer) and HIV negative (HIV-negative head and neck cancer). METHODS: Tissue microarrays (TMAs) were constructed using tumors from 41 disease site-matched and age-matched HIV-positive head and neck cancer cases and 44 HIV-negative head and neck cancer controls...
December 2017: Head & Neck
https://www.readbyqxmd.com/read/28916975/flaxseed-oil-supplementation-improve-gene-expression-levels-of-ppar-%C3%AE-lp-a-il-1-and-tnf-%C3%AE-in-type-2-diabetic-patients-with-coronary-heart-disease
#11
Ali Akbar Hashemzadeh, Nikoo Nasoohi, Fariba Raygan, Esmat Aghadavod, Elmira Akbari, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Zatollah Asemi
This study was carried out to determine the effects of flaxseed oil administration on gene expression levels related to insulin, lipid and inflammation in overweight diabetic patients with coronary heart disease (CHD). This randomized double-blind, placebo-controlled trial was conducted among 60 diabetic patients with CHD. Subjects were randomly allocated into two groups to intake either 1000 mg n-3 fatty acid from flaxseed oil containing 400 mg α-Linolenic acid [ALA (18:3n-3)] (n = 30) or placebo (n = 30) twice a day for 12 weeks...
November 2017: Lipids
https://www.readbyqxmd.com/read/28789951/hepatoprotective-activities-of-rosmarinic-acid-against-extrahepatic-cholestasis-in-rats
#12
Shih-Yi Lin, Ya-Yu Wang, Wen-Ying Chen, Su-Lan Liao, Su-Tze Chou, Ching-Ping Yang, Chun-Jung Chen
Though rosmarinic acid possesses nutritional, pharmaceutical, and toxic properties and shows therapeutic potential on liver diseases, its therapeutic effects against cholestatic liver diseases have not been proven. Using an extrahepatic cholestasis rat model by bile-duct ligation (BDL), daily oral administration of rosmarinic acid showed improvement effects on liver histology, serum biochemicals, ductular reaction, oxidative stress, inflammation, and fibrosis. Rosmarinic acid alleviated BDL-induced transforming growth factor beta-1 (TGF-β1) production and hepatic collagen deposition, and the anti-fibrotic effects were accompanied by reductions in matrix-producing cells and Smad2/3...
October 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28528475/effects-of-selenium-supplementation-on-gene-expression-levels-of-inflammatory-cytokines-and-vascular-endothelial-growth-factor-in-patients-with-gestational-diabetes
#13
Mehri Jamilian, Mansooreh Samimi, Faraneh Afshar Ebrahimi, Esmat Aghadavod, Robabeh Mohammadbeigi, Maryam Rahimi, Zatollah Asemi
Selenium is known to exert multiple beneficial effects including anti-inflammatory actions. The aim of the study was to evaluate the effects of selenium supplementation on gene expression levels of inflammatory cytokines and vascular endothelial growth factor (VEGF) in women with gestational diabetes (GDM). This randomized double-blind, placebo-controlled trial was carried out among 40 subjects diagnosed with GDM aged 18-40 years old. Subjects were randomly allocated into two groups to receive either 200 μg/day selenium supplements (n = 20) or placebo (n = 20) for 6 weeks...
February 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/28416441/glechoma-hederacea-extracts-attenuate-cholestatic-liver-injury-in-a-bile-duct-ligated-rat-model
#14
Ya-Yu Wang, Shih-Yi Lin, Wen-Ying Chen, Su-Lan Liao, Chih-Cheng Wu, Pin-Ho Pan, Su-Tze Chou, Chun-Jung Chen
ETHNOPHARMACOLOGICAL RELEVANCE: In traditional Chinese medicine, Glechoma hederacea is frequently prescribed to patients with cholelithiasis, dropsy, abscess, diabetes, inflammation, and jaundice. Polyphenolic compounds are main bioactive components of Glechoma hederacea. AIM OF THE STUDY: This study was aimed to investigate the hepatoprotective potential of hot water extract of Glechoma hederacea against cholestatic liver injury in rats. MATERIALS AND METHODS: Cholestatic liver injury was produced by ligating common bile ducts in Sprague-Dawley rats...
May 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28086769/effect-of-ginseng-extract-on-the-tgf-%C3%AE-1-signaling-pathway-in-ccl4-induced-liver-fibrosis-in-rats
#15
Mohamed M Hafez, Sherifa S Hamed, Manal F El-Khadragy, Zeinab K Hassan, Salim S Al Rejaie, Mohamed M Sayed-Ahmed, Naif O Al-Harbi, Khalid A Al-Hosaini, Mohamed M Al-Harbi, Ali R Alhoshani, Othman A Al-Shabanah, Shakir Dekhal Alsharari
BACKGROUND: Liver diseases are major global health problems. Ginseng extract has antioxidant, immune-modulatory and anti-inflammatory activities. This study investigated the effect of ginseng extract on carbon tetrachloride (CCl4)-induced liver fibrosis in rats. METHODS: Male Wistar rats were divided into four groups: control group, ginseng group, CCl4 group and CCl4 + ginseng group. Liver injury was induced by the intraperitoneal (I.P) injection of 3 ml/kg CCl4 (30% in olive oil) weekly for 8 weeks...
January 13, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27829314/bone-morphogenetic-protein-2-but-not-mesenchymal-stromal-cells-exert-regenerative-effects-on-canine-and-human-nucleus-pulposus-cells
#16
Frances C Bach, Alberto Miranda-Bedate, Ferdi W M van Heel, Frank M Riemers, Margot C M E Müller, Laura B Creemers, Keita Ito, Karin Benz, Björn P Meij, Marianna A Tryfonidou
Chronic back pain is related to intervertebral disc (IVD) degeneration and dogs are employed as animal models to develop growth factor- and cell-based regenerative treatments. In this respect, the differential effects of transforming growth factor beta-1 (TGF-β1 ) and bone morphogenetic protein-2 (BMP2) on canine and human chondrocyte-like cells (CLCs) derived from the nucleus pulposus of degenerated IVDs were studied. Human and canine CLCs were cultured in 3D microaggregates in basal culture medium supplemented with/without TGF-β1 (10 ng/mL) or BMP2 (100 or 250 ng/mL)...
March 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27794192/zinc-supplementation-augments-tgf-%C3%AE-1-dependent-regulatory-t-cell-induction
#17
Martina Maywald, Steffen K Meurer, Ralf Weiskirchen, Lothar Rink
SCOPE: Regulatory T cells (Treg) play a pivotal role in immune regulation. For proper immune function, also trace elements such as zinc, and anti-inflammatory cytokines, including transforming growth factor beta 1 (TGF-β1) and interleukin (IL)-10 are indispensable. Hence, in this study the influence of TGF-β1, IL-10, and zinc supplementation on Treg cells differentiation was investigated. METHODS AND RESULTS: A synergistic effect of a combined zinc and TGF-β1 treatment on Foxp3 expression in peripheral blood mononuclear cells and mixed lymphocyte cultures (MLC) was found by performing Western blot analysis...
March 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27787807/in-vitro-comparison-of-the-efficacy-of-tgf-%C3%AE-1-and-pdgf-bb-in-combination-with-freeze-dried-bone-allografts-for-induction-of-osteogenic-differentiation-in-mg-63-osteoblast-like-cells
#18
COMPARATIVE STUDY
Surena Vahabi, Maryam Torshabi, Azadeh Esmaeil Nejad
Predictable regeneration of alveolar bone defects has always been a challenge in implant dentistry. Bone allografts are widely used bone substitutes with controversial osteoinductive activity. This in vitro study aimed to assess the osteogenic potential of some commercially available freeze-dried bone allografts supplemented with human recombinant platelet-derived growth factor-BB and transforming growth factor beta-1. Cell viability, mineralization, and osteogenic gene expression of MG-63 osteoblast-like cells were compared among the allograft alone, allograft/platelet-derived growth factor-BB, allograft/transforming growth factor beta-1, and allograft/platelet-derived growth factor-BB/transforming growth factor beta-1 groups...
December 2016: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27574828/role-of-dietary-ginger-zingiber-officinale-in-improving-growth-performances-and-immune-functions-of-labeo-rohita-fingerlings
#19
Venkatachalam Sukumaran, Se Chang Park, Sib Sankar Giri
This study evaluated the effects of ginger (Zingiber officinale) as a feeding supplement on the growth, skin mucus immune parameters, and cytokine-related gene expression of Labeo rohita, and its susceptibility to Aeromonas hydrophila infection. Diets containing six different concentrations of dried ginger (0% [basal diet], 0.2% [G2], 0.4% [G4], 0.6% [G6], 0.8% [G8], and 1.0% [G10] were fed to fish (average weight: 12.3 g) for 60 days. Growth parameters were examined at 30 and 60 days post-feeding. Skin mucosal immune responses and gene expression were examined 60 days post-feeding...
October 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27471884/attenuation-of-carbon-tetrachloride-induced-hepatic-toxicity-by-a-dietary-supplement
#20
Zhiqiang Zheng, Richard W Gelling
Advanced liver disease (ALD) is often characterized with overt malnutrition and liver fibrosis. In this study, a dietary supplement (DS) was first developed, including branch chain amino acids, fat soluble vitamins, zinc, medium chain triglycerides, soy lecithin, L-carnitine, and n-3 polyunsaturated fatty acids. Benefits of DS were then tested using an ALD rat model treated with carbon tetrachloride (CCl4) for 6, 8, and 10 weeks, respectively. Our study showed that CCl4-induced drop of serum albumin and ratio of branch chain to aromatic amino acids were significantly prevented at all three time points...
March 4, 2017: Journal of Dietary Supplements
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