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Pseudomonas bacteremia

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https://www.readbyqxmd.com/read/27895127/the-pathogenic-potential-of-proteus-mirabilis-is-enhanced-by-other-uropathogens-during-polymicrobial-urinary-tract-infection
#1
Chelsie E Armbruster, Sara N Smith, Alexandra O Johnson, Valerie DeOrnellas, Kathryn A Eaton, Alejandra Yep, Lona Mody, Weisheng Wu, Harry L T Mobley
Urinary catheter use is prevalent in health care settings, and polymicrobial colonization by urease-positive organisms, such as Proteus mirabilis and Providencia stuartii, commonly occurs with long-term catheterization. We previously demonstrated that coinfection with P. mirabilis and P. stuartii increased overall urease activity in vitro and disease severity in a model of urinary tract infection (UTI). In this study, we expanded these findings to a murine model of catheter-associated UTI (CAUTI), delineated the contribution of enhanced urease activity to coinfection pathogenesis, and screened for enhanced urease activity with other common CAUTI pathogens...
November 28, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27863948/tree-structured-survival-analysis-of-patients-with-pseudomonas-aeruginosa-bacteremia-a-multicenter-observational-cohort-study
#2
Young Kyung Yoon, Hyun Ah Kim, Seong Yeol Ryu, Eun Jung Lee, Mi Suk Lee, Jieun Kim, Seong Yeon Park, Kyung Sook Yang, Shin Woo Kim
This study aimed to construct a prediction algorithm, which is readily applicable in the clinical setting, to determine the mortality rate for patients with P. aeruginosa bacteremia. A multicenter observational cohort study was performed retrospectively in seven university-affiliated hospitals in Korea from March 2012 to February 2015. In total, 264 adult patients with monomicrobial P. aeruginosa bacteremia were included in the analyses. Among the predictors independently associated with 30-day mortality in the Cox regression model, Pitt bacteremia score >2 and high-risk source of bacteremia were identified as critical nodes in the tree-structured survival analysis...
October 7, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27850323/684-impact-of-antibiotic-mic-in-a-va-population-with-pseudomonas-bacteremia-or-pneumonia
#3
Stephanie Bird, Shazia Raheem, Brooke Herndon, Amit Pulickan, Charlie Lan, Daniel Musher
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27826063/survival-after-multiple-traumas-is-associated-with-improved-outcomes-from-gram-negative-sepsis-clinical-and-experimental-evidence
#4
Eleftherios Mandragos, Aikaterini Pistiki, Iraklis Tsangaris, Christina Routsi, Michael Paraschos, Dionyssia-Irene Droggiti, Olga Savvidou, Dimitrios Mastrokalos, Panayiotis J Papagelopoulos, Mihai G Netea, Evangelos J Giamarellos-Bourboulis
OBJECTIVES: We investigated the susceptibility to Gram-negative sepsis after multiple traumas (MT). METHODS: From a prospective cohort of 5076 Greek patients with sepsis, 16 with Gram-negative bacteremia after MT were compared with 204 patients well-matched for severity, comorbidities and appropriateness of antimicrobials; circulating mononuclear cells were isolated and stimulated for the release of interleukin (IL)-10. Male C57Bl6J mice were subject to MT (right pneumothorax and right femur fracture) followed after 72 h by the intravenous challenge with Pseudomonas aeruginosa...
November 5, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27821456/carbapenem-resistant-pseudomonas-aeruginosa-bacteremia-risk-factors-for-mortality-and-microbiologic-treatment-failure
#5
Deanna J Buehrle, Ryan K Shields, Lloyd G Clarke, Brian A Potoski, Cornelius J Clancy, M Hong Nguyen
We reviewed 37 patients treated for bacteremia due to carbapenem-resistant Pseudomonas aeruginosa (CR-Pa). Although 65% of isolates were multiple-drug resistant, therapeutic options were available as all were susceptible to ≥1 antibiotic. Ninety-two percent of patients received active antimicrobial therapy, but only 57% received early active therapy (within 48 hours). Fourteen-day mortality was 19%. Microbiologic failure occurred in 29%. Pitt bacteremia score (P=0.046) and delayed active therapy (P=0.027) were predictive of death and microbiologic failure, respectively...
November 7, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27818808/persistent-bacteremia-from-pseudomonas-aeruginosa-with-in-vitro-resistance-to-the-novel-antibiotics-ceftolozane-tazobactam-and-ceftazidime-avibactam
#6
Louie Mar Gangcuangco, Patricia Clark, Cynthia Stewart, Goran Miljkovic, Zane K Saul
Ceftazidime-avibactam and ceftolozane-tazobactam are new antimicrobials with activity against multidrug-resistant Pseudomonas aeruginosa. We present the first case of persistent P. aeruginosa bacteremia with in vitro resistance to these novel antimicrobials. A 68-year-old man with newly diagnosed follicular lymphoma was admitted to the medical intensive care unit for sepsis and right lower extremity cellulitis. The patient was placed empirically on vancomycin and piperacillin-tazobactam. Blood cultures from Day 1 of hospitalization grew P...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27754817/acute-inflammatory-response-of-patients-with-pseudomonas-aeruginosa-infections-a-prospective-study
#7
Silvia Gómez-Zorrilla, Francisco Morandeira, María José Castro, Fe Tubau, Elisabet Periche, Rosario Cañizares, María Angeles Dominguez, Javier Ariza, Carmen Peña
The severity of Pseudomonas aeruginosa (PA) infection may be determined by the interaction with the host immune system. We designed a prospective study to assess the relationship between the inflammatory response and the clinical presentation and outcome of PA infection. We also investigated whether there are differences in the inflammatory response depending on the resistance profile of PA. Interleukin-6 (IL-6), IL-10, procalcitonin (PCT), and C-reactive protein (CRP) were measured. Sixty-nine infection episodes were recorded; 40 caused by non-multidrug-resistant (non-MDR) strains [29 (73%) respiratory; 8 (20%) bacteremia], 12 by MDR non-extensively drug-resistant (MDR-non-XDR) [9 (75%) respiratory; 3 (25%) bacteremia], and 17 by XDR strains [9 (53%) respiratory; 7 (41%) bacteremia]...
October 18, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27719726/-the-clinical-feature-and-outcomes-of-severe-aplastic-anemia-patients-suffered-from-bacteremia-following-antithymocyte-globulin
#8
X X Li, M Wang, Y Q Shao, N Nie, J Shi, Z D Huang, J Zhang, M L Ge, J B Huang, Y Z Zheng
Objective: To assess the clinical feature and outcomes of severe aplastic anemia (SAA) patients suffered from bacteremia following antithymocyte globulin (ATG). Methods: A total of 264 cases hospitalized in our hospital between Jan 2000 and July 2011 were enrolled into this study. We evaluated the associated pathogens of bacteremia, analyzed the risk factors by Logistic regression and estimated the overall survival (OS) by Kaplan-Meier method for the cohort of patients. Results: Bloodstream infections occurred in 49 patients, with a median age of 20 (4-62) years, including 38 cases with very SAA (VSAA) and 11 SAA patients...
September 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/27716406/pseudomonas-mendocina-native-valve-infective-endocarditis-a-case-report
#9
Glenn J Rapsinski, Jina Makadia, Nitin Bhanot, Zaw Min
BACKGROUND: Gram-negative microorganisms are uncommon pathogens responsible for infective endocarditis. Pseudomonas mendocina, a Gram-negative water-borne and soil-borne bacterium, was first reported to cause human infection in 1992. Since then, it has rarely been reported as a human pathogen in the literature. We describe the first case of native valve infective endocarditis due to P. mendocina in the USA. CASE PRESENTATION: A 57-year-old white man presented with bilateral large leg ulcers, fever, and marked leukocytosis...
October 4, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27703454/exome-sequencing-reveals-primary-immunodeficiencies-in-children-with-community-acquired-pseudomonas-aeruginosa-sepsis
#10
Samira Asgari, Paul J McLaren, Jane Peake, Melanie Wong, Richard Wong, Istvan Bartha, Joshua R Francis, Katia Abarca, Kyra A Gelderman, Philipp Agyeman, Christoph Aebi, Christoph Berger, Jacques Fellay, Luregn J Schlapbach
One out of three pediatric sepsis deaths in high income countries occur in previously healthy children. Primary immunodeficiencies (PIDs) have been postulated to underlie fulminant sepsis, but this concept remains to be confirmed in clinical practice. Pseudomonas aeruginosa (P. aeruginosa) is a common bacterium mostly associated with health care-related infections in immunocompromised individuals. However, in rare cases, it can cause sepsis in previously healthy children. We used exome sequencing and bioinformatic analysis to systematically search for genetic factors underpinning severe P...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27670678/successful-treatment-of-multidrug-resistant-pseudomonas-aeruginosa-breakthrough-bacteremia-with-ceftolozane-tazobactam
#11
Alberto Hernández-Tejedor, Carmen Débora Merino-Vega, Alfredo Martín-Vivas, Rafael Ruiz de Luna-González, Alberto Delgado-Iribarren, Ángeles Gabán-Díez, Ignacio Temprano-Gómez, Natalia de la Calle-Pedrosa, Ana Isabel González-Jiménez, Alejandro Algora-Weber
INTRODUCTION: Ceftolozane/tazobactam is a novel antibiotic approved for the treatment of complicated intra-abdominal and complicated urinary tract infections. CASE DESCRIPTION: We describe the use of off-label ceftolozane/tazobactam in the management of a multidrug-resistant Pseudomonas aeruginosa bacteremia that was already being treated with colistin and amikacin, the only active antibiotics according to the antibiogram.
September 26, 2016: Infection
https://www.readbyqxmd.com/read/27650231/effect-of-bacteremia-in-elderly-patients-with-urinary-tract-infection
#12
Arturo Artero, Ana Esparcia, José M Eiros, Manuel Madrazo, Juan Alberola, José M Nogueira
INTRODUCTION: The clinical effect of bacteremia on outcomes in urinary tract infection (UTI) is still debated. This study aims to examine the clinical effect of bacteremia in elderly patients with UTI requiring hospital admission. METHODS: This retrospective observational study recorded the clinical features, microbiology and outcomes in a Spanish cohort of patients aged ≥65 years hospitalized for UTI in whom blood cultures were performed in the emergency department...
September 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27622627/risk-factors-for-hospital-acquired-bacteremia-due-to-carbapenem-resistant-pseudomonas-aeruginosa-in-a-colombian-hospital
#13
Sandra Liliana Valderrama, Pedro Felipe González, María Alejandra Caro, Natalia Ardila, Beatriz Ariza, Fabián Gil, Carlos Álvarez
INTRODUCTION: Bacteremia due to Pseudomonas aeruginosa resistant to carbapenems is a public health problem due to the limitations it places on therapeutic options, as well as the increased time patients must spend in hospital, costs and the risk of mortality.  OBJECTIVE: To evaluate the risk factors for presentation of bacteremia due to carbapenem-resistant P. aeruginosa acquired in the Hospital Universitario San Ignacio between January 2008 and June 2014.  MATERIALS AND METHODS: This was a case control study in which the case patients presented bacteremia due to P...
2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27606553/2-5-mafenide-acetate-a-cost-effective-alternative-to-the-5-solution-for-burn-wounds
#14
Ashkan Afshari, Lyly Nguyen, Steven A Kahn, Blair Summitt
Mafenide acetate is an antimicrobial agent used to decrease the bacterial load for burn wounds. The 5% solution is more commonly used yet double the cost of its 2.5% counterpart. This study aims to evaluate outcomes and cost associated with the use of 2.5 vs 5% mafenide acetate formulation in the adult burn population. Adult patients (≥18 years) receiving 2.5% mafenide acetate during an 11-month period between 2014 and 2015, corresponding to a policy change in favor of the use of 2.5% mafenide acetate, were queried...
August 11, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27572416/clinical-features-and-risk-factors-for-development-of-breakthrough-gram-negative-bacteremia-during-carbapenem-therapy
#15
Ji-Yong Lee, Cheol-In Kang, Jae-Hoon Ko, Woo Joo Lee, Hye-Ri Seok, Ga Eun Park, Sun Young Cho, Young Eun Ha, Doo Ryeon Chung, Nam Yong Lee, Kyong Ran Peck, Jae-Hoon Song
BACKGROUND: With the increasing use of carbapenems, carbapenem-resistant Gram-negative bacteria have become a major concern in healthcare-associated infections. This study was performed to evaluate the clinical and microbiological features of breakthrough Gram-negative bacteremia (GNB) during carbapenem therapy and to assess risk factors for development of breakthrough GNB. METHODS: A case-control study was performed at a tertiary hospital from 2005 to 2014. Cases were defined as individuals whose blood cultures grew Gram-negative bacteria while receiving carbapenems for at least 48 hours before breakthrough GNB...
August 29, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27570854/prevalence-and-risk-factors-of-gram-negative-bacilli-causing-blood-stream-infection-in-patients-with-malignancy
#16
Fawzia E Al-Otaibi, Elham E Bukhari, Mona Badr, Abdulkarim A Alrabiaa
OBJECTIVES: To evaluate the epidemiology, risk factors, and antibiotic resistance of Gram negative bacteria (GNB) in patients with hematologic or solid organ malignancies.   METHODS: This is a retrospective study of 61 episodes of GNB bacteremia occurring in 56 patients with malignancy admitted to the Oncology Units in King Khalid University Hospital, Riyadh. Kingdom of Saudi Arabia during the period from January 2013 to October 2015. Data were retrieved from the computerized database of the microbiology laboratory and the patient's medical records...
September 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27522002/trends-in-antibiotic-resistance-among-major-bacterial-pathogens-isolated-from-blood-cultures-tested-at-a-large-private-laboratory-network-in-india-2008-2014
#17
Sumanth Gandra, Nestor Mojica, Eili Y Klein, Ashvin Ashok, Vidya Nerurkar, Mamta Kumari, Uma Ramesh, Sunanda Dey, Viral Vadwai, Bibhu R Das, Ramanan Laxminarayan
OBJECTIVE: There have been no long-term studies on trends in antibiotic resistance (ABR) on a national scale in India. Using a private laboratory network, the ABR patterns of organisms most commonly associated with bacteremia, obtained from patients across India between 2008 and 2014, were examined. METHODS: A retrospective study of patient blood cultures collected over a 7-year period (January 1, 2008-December 31, 2014) was conducted. Data on the microorganism(s) identified and their antimicrobial susceptibility were obtained from SRL Diagnostics (Mumbai, India)...
September 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27508002/pattern-and-predictors-of-mortality-in-necrotizing-fasciitis-patients-in-a-single-tertiary-hospital
#18
Gaby Jabbour, Ayman El-Menyar, Ruben Peralta, Nissar Shaikh, Husham Abdelrahman, Insolvisagan Natesa Mudali, Mohamed Ellabib, Hassan Al-Thani
BACKGROUND: Necrotizing fasciitis (NF) is a fatal aggressive infectious disease. We aimed to assess the major contributing factors of mortality in NF patients. METHODS: A retrospective study was conducted at a single surgical intensive care unit between 2000 and 2013. Patients were categorized into 2 groups based on their in-hospital outcome (survivors versus non-survivors). RESULTS: During a14-year period, 331 NF patients were admitted with a mean age of 50...
2016: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/27506948/acinetobacter-spp-are-associated-with-a-higher-mortality-in-intensive-care-patients-with-bacteremia-a-survival-analysis
#19
Aline C Q Leão, Paulo R Menezes, Maura S Oliveira, Anna S Levin
BACKGROUND: It has been challenging to determine the true clinical impact of Acinetobacter spp., due to the predilection of this pathogen to colonize and infect critically ill patients, who often have a poor prognosis. The aim of this study was to assess whether Acinetobacter spp. bacteremia is associated with lower survival compared with bacteremia caused by other pathogens in critically ill patients. METHODS: This study was performed at Hospital das Clínicas, University of São Paulo, Brazil...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27461174/difference-of-type-3-secretion-system-t3ss-effector-gene-genotypes-exou-and-exos-and-its-implication-to-antibiotics-resistances-in-isolates-of-pseudomonas-aeruginosa-from-chronic-otitis-media
#20
Min-Hyun Park, So Young Kim, Eun Yun Roh, Ho Sun Lee
OBJECTIVE: Type 3 secretion system (T3SS) is the most important virulence factor in Pseudomonas aeruginosa infection. Of the various T3SS effector genes, exoS and exoU showed mutually exclusive distributions, and these two genes showed varied virulence. In many pseudomonal infections, the distribution of these genes showed different pattern and it influenced severity of infection. This study was aimed to evaluate differences of virulence factors and antibiotics resistance between chronic otitis media and other body infection caused by P...
July 22, 2016: Auris, Nasus, Larynx
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