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Pseudomonas bacteremia

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https://www.readbyqxmd.com/read/28879405/infection-control-interventions-affected-by-resource-shortages-impact-on-the-incidence-of-bacteremias-caused-by-carbapenem-resistant-pathogens
#1
E Kousouli, O Zarkotou, L Politi, K Polimeri, G Vrioni, K Themeli-Digalaki, A Tsakris, S Pournaras
We evaluated an infection control (IC) program influenced by personnel and material resource shortages on the incidence of bloodstream infections (BSI) due to carbapenem-resistant Klebsiella pneumoniae (CRKP), Acinetobacter baumannii (CRAB), and Pseudomonas aeruginosa (CRPA) in an endemic region. Between January 2010 and December 2015, all BSI episodes caused by CRKP, CRAB, and CRPA were recorded. An IC bundle was implemented in January 2012. We evaluated the effect of the interventions on BSI rates between the pre-intervention (2010-2011) and intervention (2012-2013) periods, using an interrupted time-series model...
September 6, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28860262/complete-genome-sequences-of-two-pseudomonas-aeruginosa-strains-isolated-from-children-with-bacteremia
#2
Luis F Espinosa-Camacho, Gabriela Delgado, Guadalupe Miranda-Novales, Gloria Soberón-Chávez, Luis D Alcaraz, Rosario Morales-Espinosa
Two Pseudomonas aeruginosa strains isolated from children with bacteremia in Mexico City were sequenced using PacBio RS-II single-molecule real-time (SMRT) technology. The strains consist of a 7.0- to 7.4-Mb chromosome, with a high content of mobile elements, and variation in the genetic content of class 1 integron In1409.
August 31, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28852678/the-risk-of-cardiac-device-related-infection-in-bacteremic-patients-is-species-specific-results-of-a-12-year-prospective-cohort
#3
Stacey A Maskarinec, Joshua T Thaden, Derek D Cyr, Felicia Ruffin, Maria Souli, Vance G Fowler
BACKGROUND: The species-specific risk of cardiac device-related infection (CDRI) among bacteremic patients is incompletely understood. METHODS: We conducted a prospective cohort study of hospitalized patients from October 2002 to December 2014 with a cardiac device (CD) and either Staphylococcus aureus bacteremia (SAB) or Gram-negative bacteremia (GNB). Cardiac devices were defined as either prosthetic heart valves (PHVs), including valvular support rings, permanent pacemakers (PPMs)/automatic implantable cardioverter defibrillators (AICDs), or left ventricular assist devices (LVADs)...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28815897/multidrug-resistant-enterobacteriaceae-pseudomonas-aeruginosa-and-vancomycin-resistant-enterococci-three-major-threats-to-hematopoietic-stem-cell-transplant-recipients
#4
REVIEW
Michael J Satlin, Thomas J Walsh
Hematopoietic stem cell transplant (HSCT) recipients are uniquely threatened by the emergence of multidrug-resistant (MDR) bacteria because these patients rely on immediate active antimicrobial therapy to combat bacterial infections. This review describes the epidemiology and treatment considerations for three challenging MDR bacterial pathogens in HSCT recipients: MDR Enterobacteriaceae, including extended-spectrum β-lactamase (ESBL)-producing and carbapenem-resistant Enterobacteriaceae (CRE), Pseudomonas aeruginosa, and vancomycin-resistant Enterococcus (VRE)...
August 16, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28814278/epidemiology-and-outcomes-of-endophthalmitis-in-chronic-dialysis-patients-a-13-year-experience-in-a-tertiary-referral-center-in-taiwan
#5
George Kuo, Yueh-An Lu, Wei-Chiao Sun, Chao-Yu Chen, Huang-Kai Kao, YuJr Lin, Chia-Hui Lee, Cheng-Chieh Hung, Ya-Chung Tian, Hsiang-Hao Hsu
BACKGROUND: Endophthalmitis is a severe eye infection leading to disabling outcome. Because there were only a few case report illustrating endophthalmitis in chronic dialysis patient, we would like to investigate the epidemiology and clinical features of endophthalmitis in chronic dialysis patient in a tertiary referral center. METHODS: We searched the health information system in the study hospital with ICD9 encoding endophthalmitis during Jan. 2002 to Dec. 2015...
August 16, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28808348/rapid-phenotypic-stress-based-microfluidic-antibiotic-susceptibility-testing-of-gram-negative-clinical-isolates
#6
Maxim Kalashnikov, Marc Mueller, Christine McBeth, Jean C Lee, Jennifer Campbell, Andre Sharon, Alexis F Sauer-Budge
Bacteremia is a life-threatening condition for which antibiotics must be prescribed within hours of clinical diagnosis. Since the current gold standard for bacteremia diagnosis is based on conventional methods developed in the mid-1800s-growth on agar or in broth-identification and susceptibility profiling for both Gram-positive and Gram-negative bacterial species requires at least 48-72 h. Recent advancements in accelerated phenotypic antibiotic susceptibility testing have centered on the microscopic growth analysis of small bacterial populations...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28805355/sensing-mg-2-contributes-to-the-resistance-of-pseudomonas-aeruginosa-to-complement-mediated-opsonophagocytosis
#7
Mohammad Qadi, Sofía Izquierdo-Rabassa, Margalida Mateu Borrás, Antonio Doménech-Sánchez, Carlos Juan, Joanna B Goldberg, Robert E W Hancock, Sebastián Albertí
Pseudomonas aeruginosa adaptation to survive in the host hinges on its ability to probe the environment and respond appropriately. Rapid adaptation is often mediated by two-component regulatory systems, such as the PhoP/PhoQ system that responds to Mg(2+) ion concentration. However, there is limited information about the role of PhoQ in P. aeruginosa bloodstream infections. We used a murine model of systemic infection to test the virulence of a PhoQ-deficient mutant. Mutation of PhoQ impaired the virulence and the ability to cause bacteremia of P...
August 14, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28803838/current-epidemiology-of-resistance-among-gram-negative-bacilli-in-pediatric-patients-in-turkey
#8
Kubra Aykac, Yasemin Ozsurekci, Sevgen Tanir Basaranoglu, Mustafa Senol Akin, Ali Bulent Cengiz, Asiye Bicakcigil, Banu Sancak, Ates Kara, Mehmet Ceyhan
BACKGROUND: The increasing incidence of infections caused by drug-resistant Gram-negative organisms has led to a reemergence in worldwide. This study attempted to investigate the changes in resistance of Gram-negative bacteria to different classes of antibiotics and treatment options in invasive infections. METHODS: We performed this study retrospectively between January 2012 and January 2017 in our tertiary care university hospital. A total of 302 patients with Gram-negative bacterial bacteremia and meningitis were defined...
August 10, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28738848/influence-of-borderline-cefepime-mic-on-the-outcome-of-cefepime-susceptible-pseudomonas-aeruginosa-bacteremia-treated-with-a-maximal-cefepime-dose-a-hospital-based-retrospective-study
#9
Ting-Yi Su, Jung-Jr Ye, Chien-Chang Yang, Ching-Tai Huang, Ju-Hsin Chia, Ming-Hsun Lee
BACKGROUND: We assessed the influence of current cefepime minimal inhibitory concentration (MIC) breakpoints and the maximal cefepime dose on treatment outcomes in patients with bacteremia caused by cefepime-susceptible Pseudomonas aeruginosa. METHODS: Adult patients hospitalized between July 2010 and June 2014 with a positive blood culture for cefepime-susceptible P. aeruginosa and receipt of cefepime as the primary therapy throughout the course were reviewed. Cefepime Etest(®) MICs and clinical outcomes for P...
July 24, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28716109/clinical-characteristics-and-outcomes-of-pseudomonas-aeruginosa-bacteremia-in-febrile-neutropenic-children-and-adolescents-with-the-impact-of-antibiotic-resistance-a-retrospective-study
#10
Hyo Sup Kim, Bo Kyoung Park, Seong Koo Kim, Seung Beom Han, Jae Wook Lee, Dong-Gun Lee, Nack-Gyun Chung, Bin Cho, Dae Chul Jeong, Jin Han Kang
BACKGROUND: Although the proportion of Pseudomonas aeruginosa infections has reduced after the introduction of antibiotics with anti-pseudomonal effects, P. aeruginosa bacteremia still causes high mortality in immunocompromised patients. This study determined the clinical characteristics and outcomes of P. aeruginosa bacteremia and the antibiotic susceptibilities of strains isolated from febrile neutropenic patients. METHODS: Thirty-one febrile neutropenic children and adolescents with underlying hematologic/oncologic disorders diagnosed with P...
July 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28679339/characteristics-of-a-pseudomonas-aeruginosa-induced-porcine-sepsis-model-for-multi-organ-metabolic-flux-measurements
#11
Gabriella A M Ten Have, Renske C I Deutz, Mariëlle P K J Engelen, Robert R Wolfe, Nicolaas E P Deutz
Survival of sepsis is related to loss of muscle mass. Therefore, it is imperative to further define and understand the basic alterations in nutrient metabolism in order to improve targeted sepsis nutritional therapies. We developed and evaluated a controlled hyperdynamic severe sepsis pig model that can be used for in vivo multi-organ metabolic studies in a conscious state. In this catheterized pig model, bacteremia was induced intravenously with 10(9) CFU/h Pseudomonas aeruginosa (PA) in 13 pigs for 18 h...
January 1, 2017: Laboratory Animals
https://www.readbyqxmd.com/read/28611752/ecthyma-gangrenosum-escherichia-coli-or-pseudomonas-aeruginosa
#12
Mohamed Abbas, Stéphane Emonet, Thilo Köhler, Gesuele Renzi, Christian van Delden, Jacques Schrenzel, Bernard Hirschel
Background: Ecthyma gangrenosum (EG) are necrotic lesions that develop in the context of Pseudomonas aeruginosa bacteremia. Isolated reports describe EG in the setting of non-Pseudomonal infections. In a patient with EG, initial blood cultures showed Escherichia coli, and almost occulted P. aeruginosa bacteremia. Based on the clinical picture we suspected preponderant P. aeruginosa bacteremia, outgrown by concomitant low-grade E. coli bacteremia in the blood culture vials. Methods: We performed quantitative polymerase chain reaction (PCR) assays with specific primers for P...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28605238/mucin-1-protects-against-severe-streptococcus-pneumoniae-infection
#13
Poshmaal Dhar, Garrett Z Ng, Eileen M Dunne, Philip Sutton
Streptococcus pneumoniae is a bacterial pathogen that commonly resides in the human nasopharynx, typically without causing any disease. However, in some cases these bacteria migrate from the nasopharynx to other sites of the body such as the lungs and bloodstream causing pneumonia and sepsis, respectively. This study used a mouse model of infection to investigate the potential role of Mucin 1 (MUC1), a cell membrane-associated glycoprotein known for playing a key barrier role at mucosal surfaces, in regulating this process...
June 12, 2017: Virulence
https://www.readbyqxmd.com/read/28601359/osteopontin-exacerbates-pseudomonas-aeruginosa-induced-bacteremia-in-mice
#14
Zhenghao Piao, Haiying Yuan
Osteopontin (OPN) is a multifunctional protein involved in various pathophysiological processes. However, the role of OPN in Pseudomonas aeruginosa-related sepsis is not yet clear. Here, we found that OPN expression was elevated in plasma and spleen samples from P. aeruginosa-infected mice. To determine the function of OPN in sepsis, we used wild-type (WT) and OPN-knockout (KO) mice with P. aeruginosa-induced bacteremia. We found that OPN-KO mice exhibited reduced mortality compared with WT mice and that OPN exacerbated spleen bleeding and functional impairment...
August 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28569671/degradable-magnesium-implant-associated-infections-by-bacterial-biofilms-induce-robust-localized-and-systemic-inflammatory-reactions-in-a-mouse-model
#15
Muhammad Imran Rahim, Anshu Babbar, Stefan Lienenklaus, Marina C Pils, Manfred Rohde
Biomaterial-associated Pseudomonas aeruginosa biofilm infections constitute a cascade of host immune reactions ultimately leading to implant failure. Due to the lack of relevant in vivo biofilm models, the majority of the studies report host immune responses to free-living or planktonic bacteria, while bacteria in clinical situations live more frequently as biofilm communities than as single cells. The present study investigated host immune responses to biomaterial-associated P. aeruginosa biofilms in a clinically relevant mouse model...
September 13, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28522850/pseudomonas-aeruginosa-exolysin-promotes-bacterial-growth-in-lungs-alveolar-damage-and-bacterial-dissemination
#16
Stéphanie Bouillot, Patrick Munro, Benoit Gallet, Emeline Reboud, François Cretin, Guillaume Golovkine, Guy Schoehn, Ina Attrée, Emmanuel Lemichez, Philippe Huber
Exolysin (ExlA) is a recently-identified pore-forming toxin secreted by a subset of Pseudomonas aeruginosa strains identified worldwide and devoid of Type III secretion system (T3SS), a major virulence factor. Here, we characterized at the ultrastructural level the lesions caused by an ExlA-secreting strain, CLJ1, in mouse infected lungs. CLJ1 induced necrotic lesions in pneumocytes and endothelial cells, resulting in alveolo-vascular barrier breakdown. Ectopic expression of ExlA in an exlA-negative strain induced similar tissue injuries...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28481953/molecular-epidemiological-survey-of-bacteremia-by-multidrug-resistant-pseudomonas-aeruginosa-the-relevance-of-intrinsic-resistance-mechanisms
#17
Raquel Cristina Cavalcanti Dantas, Rebecca Tavares E Silva, Melina Lorraine Ferreira, Iara Rossi Gonçalves, Bruna Fuga Araújo, Paola Amaral de Campos, Sabrina Royer, Deivid William da Fonseca Batistão, Paulo Pinto Gontijo-Filho, Rosineide Marques Ribas
The bacterial factors associated with bacteremia by multidrug-resistant and extensively drug-resistant P. aeruginosa, including overexpression of efflux pumps, AmpC overproduction, and loss/alteration of the OprD porin in isolates that are non-Metallo-β-Lactamase producing were analyzed in a retrospective study. Molecular analyses included strain typing by Pulsed Field Gel Electrophoresis and identification of key genes via qualitative and quantitative PCR-based assays. Previous use of carbapenems and tracheostomy was independently associated with the development of bacteremia by extensively drug-resistant and multidrug-resistant strains of P...
2017: PloS One
https://www.readbyqxmd.com/read/28463232/bispecific-antibody-targets-multiple-pseudomonas-aeruginosa-evasion-mechanisms-in-the-lung-vasculature
#18
Ajitha Thanabalasuriar, Bas Gj Surewaard, Michelle E Willson, Arpan S Neupane, Charles K Stover, Paul Warrener, George Wilson, Ashley E Keller, Bret R Sellman, Antonio DiGiandomenico, Paul Kubes
Pseudomonas aeruginosa is a major cause of severe infections that lead to bacteremia and high patient mortality. P. aeruginosa has evolved numerous evasion and subversion mechanisms that work in concert to overcome immune recognition and effector functions in hospitalized and immunosuppressed individuals. Here, we have used multilaser spinning-disk intravital microscopy to monitor the blood-borne stage in a murine bacteremic model of P. aeruginosa infection. P. aeruginosa adhered avidly to lung vasculature, where patrolling neutrophils and other immune cells were virtually blind to the pathogen's presence...
June 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28458762/bacteremia-or-pseudobacteremia-review-of-pseudomonas-fluorescens-infections
#19
Takeshi Nishimura, Kenji Hattori, Akihiko Inoue, Taiji Ishii, Tetsuya Yumoto, Kohei Tsukahara, Astunori Nakao, Satoshi Ishihara, Shinichi Nakayama
No abstract text is available yet for this article.
2017: World Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28416553/pharmacokinetics-and-dialytic-clearance-of-ceftazidime-avibactam-in-a-critically-ill-patient-on-continuous-venovenous-hemofiltration
#20
Eric Wenzler, Kristen L Bunnell, Susan C Bleasdale, Scott Benken, Larry H Danziger, Keith A Rodvold
Ceftazidime-avibactam administered at 1.25 g every 8 h was used to treat multidrug-resistant Pseudomonas aeruginosa bacteremia in a critically ill patient on continuous venovenous hemofiltration (CVVH). Prefiltration plasma drug concentrations of ceftazidime and avibactam were measured at 0, 1, 2, 4, 6, and 8 h along with postfiltration and ultrafiltrate concentrations at h 2 and h 6. Plasma pharmacokinetic parameters of ceftazidime and avibactam, respectively, were as follows: maximum plasma concentration (Cmax), 61...
July 2017: Antimicrobial Agents and Chemotherapy
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