Canzhen Liu, Xiaoxu Wang, Xiaonan Wang, Yunfang Zhang, Wenjian Min, Ping Yu, Jinhua Miao, Weiwei Shen, Shuangqin Chen, Shan Zhou, Xiaolong Li, Ping Meng, Qinyu Wu, Fan Fan Hou, Youhua Liu, Peng Yang, Cheng Wang, Xu Lin, Lan Tang, Xuefeng Zhou, Lili Zhou
Background: Liver kinase B1 (LKB1) is the key regulator of energy metabolism and cell homeostasis. LKB1 dysfunction plays a key role in renal fibrosis. However, LKB1 activators are scarce in commercial nowadays. This study aims to discover a new drug molecule, piericidin analogue S14 (PA-S14), preventing renal fibrosis as a novel activator to LKB1. Methods: Our group isolated PA-S14 from the broth culture of a marine-derived Streptomyces strain and identified its binding site. We adopted various CKD models or AKI-CKD model (5/6 nephrectomy, UUO, UIRI and adriamycin nephropathy models)...
2022: Theranostics