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TGF- beta AND nephropathy

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https://www.readbyqxmd.com/read/28319415/transforming-growth-factor-beta-1-an-important-biomarker-for-developing-cardiovascular-diseases-in-chronic-renal-failure
#1
E Avci, G Alp Avci, B Ozcelik, S Coskun Cevher, M Suicmez
OBJECTIVE: Our study focuses on the determination and evaluation of TGF-β1 levels of patients receiving hemodialysis treatment because of chronic renal failure. BACKGROUND: Chronic renal failure, characterized by irreversible loss of renal function, is a major public health problem in the world. Transforming growth factor-beta is a multifunctional cytokine involved in the cellular growth, differentiation, migration, apoptosis and immune regulation. Among the three TGF-β isoforms, TGF-β1 plays a key role in the pathogenesis of renal diseases...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28245472/role-of-protease-activated-receptor-2-in-regulating-focal-segmental-glomerulosclerosis
#2
Yongjun Wang, Yanfa He, Mingzheng Wang, Pei Lv, Jianzhen Liu, Junxia Wang
Background /Aims: The underlying mechanisms leading to focal segmental glomerulosclerosis (FSGS) are lacking. In this report, we examined the role of protease-activated receptors (PARs) subtype PAR2 and its downstream signals in regulating the pathophysiological process of FSGS. METHODS: Nephropathy was induced by intravenous injections of adriamycin (ADR) in rats to study FSGS. Western Blot analysis and ELISA were employed to determine the protein expression levels of PAR2 and its downstream signal pathways as well as the levels of PICs...
February 28, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28214865/inhibition-of-trpc6-signal-pathway-alleviates-podocyte-injury-induced-by-tgf-%C3%AE-1
#3
Haiting Huang, Yanwu You, Xu Lin, Chunrong Tang, Xiangjun Gu, Meiying Huang, Youling Qin, Junhua Tan, Feifan Huang
BACKGROUND/AIMS: Transforming growth factor beta 1 (TGF-β1) plays a critical role in the pathogenesis of glomerulosclerosis. The purpose of this study was to examine the effects of inhibition of transient receptor potential cation channel C6 (TRPC6) on podocyte injury induced by TGF-β1 via nephrin and desmin mechanisms. METHODS: A rat model of nephropathy was first induced by intravenous injections of adriamycin to determine TRPC6 signal pathway engaged in glomerulosclerosis in vivo...
January 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28123632/effects-of-averrhoa-carambola-l-oxalidaceae-juice-mediated-on-hyperglycemia-hyperlipidemia-and-its-influence-on-regulatory-protein-expression-in-the-injured-kidneys-of-streptozotocin-induced-diabetic-mice
#4
Hoa Thi Thai Pham, Wansu Huang, Chuangye Han, Juman Li, Qiuqiao Xie, Jinbin Wei, Xiaohui Xu, Zefeng Lai, Xiang Huang, Renbin Huang, Qingwei Wen
Recently, many reports have shown that Averrhoa carambola L. (Oxalidaceae) juice (EACJ) could reduce blood glucose in humans. However, its mechanisms have not been well explored; therefore, our study aimed to investigate the beneficial effects of EACJ on hyperglycemia, hyperlipidemia and renal injury in streptozotocin (STZ)-induced diabetic mice. Those mice were injected with STZ via the tail vein (120 mg/kg body weight) and were identified as diabetic mice when the level of blood glucose was ≥ 11.1 mmol/L...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28111218/betanin-isolated-from-fruits-of-opuntia-elatior-mill-attenuates-renal-fibrosis-in-diabetic-rats-through-regulating-oxidative-stress-and-tgf-%C3%AE-pathway
#5
Brijesh Sutariya, Madhusudan Saraf
ETHNOPHARMACOLOGICAL RELEVANCE: The fruits of Opuntia elatior Mill are being used traditionally in different disease condition like diabetes, obesity, asthma, inflammatory disorders, and anemia. Betanin, a compound isolated from fruits of Opuntia elatior Mill has potent anti-oxidative and anti-inflammatory activity. Recent study from our lab indicated the protective effect of betanin against high glucose induced rat renal epithelial cell fibrosis and matrix accumulation, major features of diabetic nephropathy (DN)...
January 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28060893/positioning-of-tacrolimus-for-the-treatment-of-diabetic-nephropathy-based-on-computational-network-analysis
#6
Constantin Aschauer, Paul Perco, Andreas Heinzel, Judith Sunzenauer, Rainer Oberbauer
OBJECTIVE: To evaluate tacrolimus as therapeutic option for diabetic nephropathy (DN) based on molecular profile and network-based molecular model comparisons. MATERIALS AND METHODS: We generated molecular models representing pathophysiological mechanisms of DN and tacrolimus mechanism of action (MoA) based on literature derived data and transcriptomics datasets. Shared enriched molecular pathways were identified based on both model datasets. A newly generated transcriptomics dataset studying the effect of tacrolimus on mesangial cells in vitro was added to identify mechanisms in DN pathophysiology...
2017: PloS One
https://www.readbyqxmd.com/read/27988328/emodin-self-emulsifying-platform-ameliorates-the-expression-of-fn-icam-1-and-tgf-%C3%AE-1-in-ages-induced-glomerular-mesangial-cells-by-promoting-absorption
#7
Jiani Huang, Wenyan Gong, Zhiquan Chen, Junying Huang, Qiuhong Chen, Heqing Huang, Chunshun Zhao
Emodin, a potential anti-diabetic nephropathy agent, is limited by its oral use due to the poor water solubility. The present study aimed to enhance the absorption and the suppressive effects of emodin on renal fibrosis by developing a self-microemulsifying drug delivery system (SMEDDS). Solubility studies, compatibility tests, pseudo-ternary phase diagrams analysis and central composite design were carried out to obtain the optimized formulation. The average droplet size of emodin-loaded SMEDDS was about 18...
March 1, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27976371/apolipoprotein-c-i-plays-a-role-in-the-pathogenesis-of-glomerulosclerosis
#8
Pascal Bus, Louise Pierneef, Rosalie Bor, Ron Wolterbeek, Leendert A van Es, Patrick Cn Rensen, Emile de Heer, Louis M Havekes, Jan A Bruijn, Jimmy F Berbée, Hans J Baelde
Diabetic nephropathy is the leading cause of end-stage renal disease. Diabetic patients have increased plasma concentrations of apolipoprotein C-I (apoCI), and meta-analyses found that a polymorphism in APOC1 is associated with an increased risk of developing nephropathy. To investigate whether overexpressing apoCI contributes to the development of kidney damage, we studied renal tissue and peritoneal macrophages from APOC1 transgenic (APOC1-tg) mice and wild-type littermates. In addition, we examined renal material from autopsied diabetic patients with and without diabetic nephropathy and from autopsied control subjects...
December 15, 2016: Journal of Pathology
https://www.readbyqxmd.com/read/27882817/h2s-improves-renal-fibrosis-in-stz-induced-diabetic-rats-by-ameliorating-tgf-%C3%AE-1-expression
#9
Yan Li, Lin Li, Ou Zeng, Jun Mao Liu, Jun Yang
Nephropathy develops in many patients with type 1 diabetes mellitus (T1DM). However, the specific mechanisms and therapies remain unclear. For this purpose we investigated the effects of hydrogen sulfide (H2S) on renal fibrosis in streptozotocin (STZ) induced diabetic rats and its underlying mechanisms. Experimental rats were randomly divided into four groups: Control group (normal rats), DM group (diabetes rats), DM + NaHS group [diabetes rats treated with sodium hydrosulfide (NaHS)], and NaHS group (normal rats treated with NaHS)...
November 24, 2016: Renal Failure
https://www.readbyqxmd.com/read/27826032/sterol-regulatory-element-binding-protein-srebp-1-is-a-novel-regulator-of-the-transforming-growth-factor-tgf-%C3%AE-receptor-i-t%C3%AE-ri-through-exosomal-secretion
#10
Richard Van Krieken, Guang Chen, Bo Gao, Jolene Read, Hassan A Al Saleh, Renzhong Li, Khalid Al-Nedawi, Joan C Krepinsky
Accumulation of matrix in the glomerulus is a classic hallmark of diabetic nephropathy. The profibrotic cytokine transforming growth factor beta 1 (TGF-β1) plays a central role in the development of glomerular sclerosis. Recent studies have demonstrated that the transcription factor sterol regulatory element binding protein (SREBP)-1 is an important regulator of glomerular sclerosis through both induction of TGF-β1 as well as facilitation of its signaling. Here we have identified that SREBP-1 is also a novel regulator of TGF-β receptor I (TβRI) expression in kidney mesangial cells...
January 2017: Cellular Signalling
https://www.readbyqxmd.com/read/27679717/cardiovascular-renal-complications-and-the-possible-role-of-plasminogen-activator-inhibitor-a-review
#11
John A D'Elia, George Bayliss, Ray E Gleason, Larry A Weinrauch
Since angiotensin increases the expression of plasminogen activator inhibitor (PAI), mechanisms associated with an actively functioning renin-angiotensin-aldosterone system can be expected to be associated with increased PAI-1 expression. These mechanisms are present not only in common conditions resulting in glomerulosclerosis associated with aging, diabetes or genetic mutations, but also in autoimmune disease (like scleroderma and lupus), radiation injury, cyclosporine toxicity, allograft nephropathy and ureteral obstruction...
October 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27648419/different-risk-indictors-of-diabetic-nephropathy-in-transforming-growth-factor-beta1-t869c-cc-ct-genotype-and-tt-genotype
#12
Xin Mou, Yinghui Liu, Diyi Zhou, Yongbin Hu, Guoling Ma, Chengmin Shou, Jiawei Chen, Danyang Zhou
BACKGROUND: Transforming growth factor-beta 1(TGF-β1) T869C (rs1800470, the same below) gene polymorphism is notably relative with the development of Diabetic Nephropathy (DN), and CC/CT genotype diabetic have higher frequency of than TT genotype diabetic. To find out individual risk factors in the two genotypes especially in susceptible genotype could provide more efficient and targeted prevention. METHODS: This was a prospective cohort study. A total of 251 type 2 diabetes mellitus (T2DM) patients [53...
June 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27612855/anti-diabetic-and-renoprotective-effects-of-aliskiren-in-streptozotocin-induced-diabetic-nephropathy-in-female-rats
#13
COMPARATIVE STUDY
Amal M Mahfoz, Hekma A Abd El-Latif, Lamiaa A Ahmed, Nahed M Hassanein, Afaf A Shoka
Since chronic kidney disease due to diabetic nephropathy (DN) is becoming an ever larger health burden worldwide, more effective therapies are desperately needed. In the present study, the anti-diabetic and renoprotective effects of aliskiren have been evaluated in streptozotocin (STZ)-induced DN in rats. DN was induced by a single intraperitoneal injection of STZ (65 mg/kg). Three weeks after STZ, rats were divided into four groups; normal, diabetic, diabetic treated with gliclazide (10 mg/kg/day) for 1 month, and diabetic treated with aliskiren (50 mg/kg/day) for 1 month...
December 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27602565/gsta3-attenuates-renal-interstitial-fibrosis-by-inhibiting-tgf-beta-induced-tubular-epithelial-mesenchymal-transition-and-fibronectin-expression
#14
Yun Xiao, Jishi Liu, Yu Peng, Xuan Xiong, Ling Huang, Huixiang Yang, Jian Zhang, Lijian Tao
Tubular epithelial-mesenchymal transition (EMT) has been widely accepted as the underlying mechanisms of renal interstitial fibrosis (RIF). The production of reactive oxygen species (ROS) plays a vital role in tubular EMT process. The purpose of this study was to investigate the involved molecular mechanisms in TGF-beta-induced EMT and identify the potential role of glutathione S-transferase alpha 3 (GSTA3) in this process. The iTRAQ screening was performed to identify protein alterations of the rats underwent unilateral-ureteral obstruction (UUO)...
2016: PloS One
https://www.readbyqxmd.com/read/27585521/persistent-insulin-resistance-in-podocytes-caused-by-epigenetic-changes-of-shp-1-in-diabetes
#15
Farah Lizotte, Benoit Denhez, Andréanne Guay, Nicolas Gévry, Anne Marie Côté, Pedro Geraldes
Poor glycemic control profoundly impacts protein expression and cell signaling action that contributes to glycemic memory and irreversible progression of diabetic nephropathy (DN). We have demonstrated that SHP-1 is elevated in podocytes of diabetic mice causing insulin unresponsiveness and DN. Thus, sustained SHP-1 expression caused by hyperglycemia despite systemic glucose normalization could contribute to the glycemic memory effect in DN. Microalbuminuria, GFR, mesangial cell expansion, collagen IV and TGF-β expression were significantly increased in diabetic Ins2(+/C96Y) mice compared to non-diabetic Ins2(+/+) mice and remained elevated despite glucose normalization with insulin implants...
September 1, 2016: Diabetes
https://www.readbyqxmd.com/read/27525285/oxidative-stress-in-diabetic-nephropathy-with-early-chronic-kidney-disease
#16
REVIEW
Alejandra Guillermina Miranda-Díaz, Leonardo Pazarín-Villaseñor, Francisco Gerardo Yanowsky-Escatell, Jorge Andrade-Sierra
The increase in the prevalence of diabetes mellitus (DM) and the secondary kidney damage produces diabetic nephropathy (DN). Early nephropathy is defined as the presence of microalbuminuria (30-300 mg/day), including normal glomerular filtration rate (GFR) or a mildly decreased GFR (60-89 mL/min/1.73 m(2)), with or without overt nephropathy. The earliest change caused by DN is hyperfiltration with proteinuria. The acceptable excretion rate of albumin in urine is <30 mg/day. Albuminuria represents the excretion of >300 mg/day...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27422712/effect-of-astragalus-injection-on-renal-tubular-epithelial-transdifferentiation-in-type-2-diabetic-mice
#17
Yue-E Yi, Shu-Yu Li, Yan-Na Nie, De-Xian Jia, Zhi-Hui Zhang, Yan-Fei Wang, Qian Wang
BACKGROUND: Astragalus injection is used by practitioners of traditional Chinese medicine to treat diabetic nephropathy (DN). The current study was conducted to determine the effect of astragalus on tubular epithelial transdifferentiation during the progression of DN in KKAy mice, as well as to investigate the molecular mechanism underlying this effect. METHODS: Diabetic, 14-week-old, male KKAy mice were randomly divided into a model group and an astragalus treatment group, while age-matched male C57BL/6 J mice were selected as controls...
July 16, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27317945/tgr5-activation-suppressed-s1p-s1p2-signaling-and-resisted-high-glucose-induced-fibrosis-in-glomerular-mesangial-cells
#18
Zhiying Yang, Fengxiao Xiong, Yu Wang, Wenyan Gong, Junying Huang, Cheng Chen, Peiqing Liu, Heqing Huang
Glucose and lipid metabolism disorders and chronic inflammation in the kidney tissues are largely responsible for causative pathological mechanism of renal fibrosis in diabetic nephropathy (DN). As our previous findings confirmed that, sphingosine 1-phosphate (S1P)/sphingosine 1-phosphate receptor 2 (S1P2) signaling activation promoted renal fibrosis in diabetes. Numerous studies have demonstrated that the G protein-coupled bile acid receptor TGR5 exhibits effective regulation of glucose and lipid metabolism and anti-inflammatory effects...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27261587/combination-of-telmisartan-with-sildenafil-ameliorate-progression-of-diabetic-nephropathy-in-streptozotocin-induced-diabetic-model
#19
Nageh Ahmed El-Mahdy, Magda El-Sayed El-Sayad, Aya Hassan El-Kadem
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in the world. Several signaling pathways are involved in the pathogenesis of DN including elevation in level of angiotensin II, formation of advanced glycation end products (AGE), activation of protein kinase c (PKC), and lipid accumulation. These pathways activate one another mutually leading to oxidative stress, increasing expression of transforming growth factor beta-1(TGF-β 1) and release of interleukins and adhesion molecules, so the aim of this study is to interrupt more than pathogenic pathway to ameliorate the progression of DN...
July 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27194829/th1-th2-and-treg-t17-cytokines-in-two-types-of-proliferative-glomerulonephritis
#20
M Stangou, C Bantis, M Skoularopoulou, L Korelidou, D Kouloukouriotou, M Scina, I T Labropoulou, N M Kouri, A Papagianni, G Efstratiadis
IgA nephropathy (IgAN) and focal segmental necrotizing glomerulonephritis (FSNGN) are characterized by proliferation of native glomerular cells and infiltration by inflammatory cells. Several cytokines act as mediators of kidney damage in both diseases. The aim of the present study was to investigate the role of Th1, Th2 and Treg/T17 cytokines in these types of proliferative glomerulonephritis. Simultaneous measurement of Th1 interleukin (IL-2, IL-12, tumor necrosis factor-alpha [TNF-α], interferon-gamma [INF-γ]), Th2 (IL-4, IL-5, IL-6, IL-10, IL-13), Treg/T17 transforming growth factor-beta 1 (TGF-β1, granulocyte-macrophage colony-stimulating factor [GM-CSF], IL-17) cytokines and C-C chemokines Monocyte chemoattractant protein-1 (MCP-1, macrophage inflammatory protein-1 [MIP-1] β) was performed in first-morning urine samples, at the day of renal biopsy, using a multiplex cytokine assay...
May 2016: Indian Journal of Nephrology
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