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TGF- beta AND nephropathy

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https://www.readbyqxmd.com/read/27882817/h2s-improves-renal-fibrosis-in-stz-induced-diabetic-rats-by-ameliorating-tgf-%C3%AE-1-expression
#1
Yan Li, Lin Li, Ou Zeng, Jun Mao Liu, Jun Yang
Nephropathy develops in many patients with type 1 diabetes mellitus (T1DM). However, the specific mechanisms and therapies remain unclear. For this purpose we investigated the effects of hydrogen sulfide (H2S) on renal fibrosis in streptozotocin (STZ) induced diabetic rats and its underlying mechanisms. Experimental rats were randomly divided into four groups: Control group (normal rats), DM group (diabetes rats), DM + NaHS group [diabetes rats treated with sodium hydrosulfide (NaHS)], and NaHS group (normal rats treated with NaHS)...
November 24, 2016: Renal Failure
https://www.readbyqxmd.com/read/27826032/sterol-regulatory-element-binding-protein-srebp-1-is-a-novel-regulator-of-the-transforming-growth-factor-tgf-%C3%AE-receptor-i-t%C3%AE-ri-through-exosomal-secretion
#2
Richard Van Krieken, Guang Chen, Bo Gao, Jolene Read, Hassan A Al Saleh, Renzhong Li, Khalid Al-Nedawi, Joan C Krepinsky
Accumulation of matrix in the glomerulus is a classic hallmark of diabetic nephropathy. The profibrotic cytokine transforming growth factor beta 1 (TGF-β1) plays a central role in the development of glomerular sclerosis. Recent studies have demonstrated that the transcription factor sterol regulatory element binding protein (SREBP)-1 is an important regulator of glomerular sclerosis through both induction of TGF-β1 as well as facilitation of its signaling. Here we have identified that SREBP-1 is also a novel regulator of TGF-β receptor I (TβRI) expression in kidney mesangial cells...
November 5, 2016: Cellular Signalling
https://www.readbyqxmd.com/read/27679717/cardiovascular-renal-complications-and-the-possible-role-of-plasminogen-activator-inhibitor-a-review
#3
John A D'Elia, George Bayliss, Ray E Gleason, Larry A Weinrauch
Since angiotensin increases the expression of plasminogen activator inhibitor (PAI), mechanisms associated with an actively functioning renin-angiotensin-aldosterone system can be expected to be associated with increased PAI-1 expression. These mechanisms are present not only in common conditions resulting in glomerulosclerosis associated with aging, diabetes or genetic mutations, but also in autoimmune disease (like scleroderma and lupus), radiation injury, cyclosporine toxicity, allograft nephropathy and ureteral obstruction...
October 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27648419/different-risk-indictors-of-diabetic-nephropathy-in-transforming-growth-factor-beta1-t869c-cc-ct-genotype-and-tt-genotype
#4
Xin Mou, Yinghui Liu, Diyi Zhou, Yongbin Hu, Guoling Ma, Chengmin Shou, Jiawei Chen, Danyang Zhou
BACKGROUND: Transforming growth factor-beta 1(TGF-β1) T869C (rs1800470, the same below) gene polymorphism is notably relative with the development of Diabetic Nephropathy (DN), and CC/CT genotype diabetic have higher frequency of than TT genotype diabetic. To find out individual risk factors in the two genotypes especially in susceptible genotype could provide more efficient and targeted prevention. METHODS: This was a prospective cohort study. A total of 251 type 2 diabetes mellitus (T2DM) patients [53...
June 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27612855/anti-diabetic-and-renoprotective-effects-of-aliskiren-in-streptozotocin-induced-diabetic-nephropathy-in-female-rats
#5
Amal M Mahfoz, Hekma A Abd El-Latif, Lamiaa A Ahmed, Nahed M Hassanein, Afaf A Shoka
Since chronic kidney disease due to diabetic nephropathy (DN) is becoming an ever larger health burden worldwide, more effective therapies are desperately needed. In the present study, the anti-diabetic and renoprotective effects of aliskiren have been evaluated in streptozotocin (STZ)-induced DN in rats. DN was induced by a single intraperitoneal injection of STZ (65 mg/kg). Three weeks after STZ, rats were divided into four groups; normal, diabetic, diabetic treated with gliclazide (10 mg/kg/day) for 1 month, and diabetic treated with aliskiren (50 mg/kg/day) for 1 month...
September 9, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27602565/gsta3-attenuates-renal-interstitial-fibrosis-by-inhibiting-tgf-beta-induced-tubular-epithelial-mesenchymal-transition-and-fibronectin-expression
#6
Yun Xiao, Jishi Liu, Yu Peng, Xuan Xiong, Ling Huang, Huixiang Yang, Jian Zhang, Lijian Tao
Tubular epithelial-mesenchymal transition (EMT) has been widely accepted as the underlying mechanisms of renal interstitial fibrosis (RIF). The production of reactive oxygen species (ROS) plays a vital role in tubular EMT process. The purpose of this study was to investigate the involved molecular mechanisms in TGF-beta-induced EMT and identify the potential role of glutathione S-transferase alpha 3 (GSTA3) in this process. The iTRAQ screening was performed to identify protein alterations of the rats underwent unilateral-ureteral obstruction (UUO)...
2016: PloS One
https://www.readbyqxmd.com/read/27585521/persistent-insulin-resistance-in-podocytes-caused-by-epigenetic-changes-of-shp-1-in-diabetes
#7
Farah Lizotte, Benoit Denhez, Andréanne Guay, Nicolas Gévry, Anne Marie Côté, Pedro Geraldes
Poor glycemic control profoundly impacts protein expression and cell signaling action that contributes to glycemic memory and irreversible progression of diabetic nephropathy (DN). We have demonstrated that SHP-1 is elevated in podocytes of diabetic mice causing insulin unresponsiveness and DN. Thus, sustained SHP-1 expression caused by hyperglycemia despite systemic glucose normalization could contribute to the glycemic memory effect in DN. Microalbuminuria, GFR, mesangial cell expansion, collagen IV and TGF-β expression were significantly increased in diabetic Ins2(+/C96Y) mice compared to non-diabetic Ins2(+/+) mice and remained elevated despite glucose normalization with insulin implants...
September 1, 2016: Diabetes
https://www.readbyqxmd.com/read/27525285/oxidative-stress-in-diabetic-nephropathy-with-early-chronic-kidney-disease
#8
REVIEW
Alejandra Guillermina Miranda-Díaz, Leonardo Pazarín-Villaseñor, Francisco Gerardo Yanowsky-Escatell, Jorge Andrade-Sierra
The increase in the prevalence of diabetes mellitus (DM) and the secondary kidney damage produces diabetic nephropathy (DN). Early nephropathy is defined as the presence of microalbuminuria (30-300 mg/day), including normal glomerular filtration rate (GFR) or a mildly decreased GFR (60-89 mL/min/1.73 m(2)), with or without overt nephropathy. The earliest change caused by DN is hyperfiltration with proteinuria. The acceptable excretion rate of albumin in urine is <30 mg/day. Albuminuria represents the excretion of >300 mg/day...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27422712/effect-of-astragalus-injection-on-renal-tubular-epithelial-transdifferentiation-in-type-2-diabetic-mice
#9
Yue-E Yi, Shu-Yu Li, Yan-Na Nie, De-Xian Jia, Zhi-Hui Zhang, Yan-Fei Wang, Qian Wang
BACKGROUND: Astragalus injection is used by practitioners of traditional Chinese medicine to treat diabetic nephropathy (DN). The current study was conducted to determine the effect of astragalus on tubular epithelial transdifferentiation during the progression of DN in KKAy mice, as well as to investigate the molecular mechanism underlying this effect. METHODS: Diabetic, 14-week-old, male KKAy mice were randomly divided into a model group and an astragalus treatment group, while age-matched male C57BL/6 J mice were selected as controls...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27317945/tgr5-activation-suppressed-s1p-s1p2-signaling-and-resisted-high-glucose-induced-fibrosis-in-glomerular-mesangial-cells
#10
Zhiying Yang, Fengxiao Xiong, Yu Wang, Wenyan Gong, Junying Huang, Cheng Chen, Peiqing Liu, Heqing Huang
Glucose and lipid metabolism disorders and chronic inflammation in the kidney tissues are largely responsible for causative pathological mechanism of renal fibrosis in diabetic nephropathy (DN). As our previous findings confirmed that, sphingosine 1-phosphate (S1P)/sphingosine 1-phosphate receptor 2 (S1P2) signaling activation promoted renal fibrosis in diabetes. Numerous studies have demonstrated that the G protein-coupled bile acid receptor TGR5 exhibits effective regulation of glucose and lipid metabolism and anti-inflammatory effects...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27261587/combination-of-telmisartan-with-sildenafil-ameliorate-progression-of-diabetic-nephropathy-in-streptozotocin-induced-diabetic-model
#11
Nageh Ahmed El-Mahdy, Magda El-Sayed El-Sayad, Aya Hassan El-Kadem
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in the world. Several signaling pathways are involved in the pathogenesis of DN including elevation in level of angiotensin II, formation of advanced glycation end products (AGE), activation of protein kinase c (PKC), and lipid accumulation. These pathways activate one another mutually leading to oxidative stress, increasing expression of transforming growth factor beta-1(TGF-β 1) and release of interleukins and adhesion molecules, so the aim of this study is to interrupt more than pathogenic pathway to ameliorate the progression of DN...
July 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27194829/th1-th2-and-treg-t17-cytokines-in-two-types-of-proliferative-glomerulonephritis
#12
M Stangou, C Bantis, M Skoularopoulou, L Korelidou, D Kouloukouriotou, M Scina, I T Labropoulou, N M Kouri, A Papagianni, G Efstratiadis
IgA nephropathy (IgAN) and focal segmental necrotizing glomerulonephritis (FSNGN) are characterized by proliferation of native glomerular cells and infiltration by inflammatory cells. Several cytokines act as mediators of kidney damage in both diseases. The aim of the present study was to investigate the role of Th1, Th2 and Treg/T17 cytokines in these types of proliferative glomerulonephritis. Simultaneous measurement of Th1 interleukin (IL-2, IL-12, tumor necrosis factor-alpha [TNF-α], interferon-gamma [INF-γ]), Th2 (IL-4, IL-5, IL-6, IL-10, IL-13), Treg/T17 transforming growth factor-beta 1 (TGF-β1, granulocyte-macrophage colony-stimulating factor [GM-CSF], IL-17) cytokines and C-C chemokines Monocyte chemoattractant protein-1 (MCP-1, macrophage inflammatory protein-1 [MIP-1] β) was performed in first-morning urine samples, at the day of renal biopsy, using a multiplex cytokine assay...
May 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27112839/synergistic-effects-of-c-jun-and-sp1-in-the-promotion-of-tgf%C3%AE-1-mediated-diabetic-nephropathy-progression
#13
Pan Gao, Yingze Wei, Zhigang Zhang, Wenjiao Zeng, Daming Sun, Danyang Liu, Bo Hou, Congying Zhang, Nong Zhang, Hui Li, Liliang Li
Diabetic nephropathy (DN) is a major complication of diabetes mellitus. Transforming growth factor beta 1 (TGFβ1) is a well-distinguished mediator of progressive renal fibrosis in DN. However, the molecular mechanisms contributing to enhanced TGFβ1 expression in the progression of DN are not fully understood. Herein, we reported that c-Jun and specificity protein 1 (SP1) were critical upstream regulators of TGFβ1 expression in DN. The increase in c-Jun and SP1 expressions was positively correlated with TGFβ1 in both high glucose-treated human renal mesangial cells (HRMCs) and diabetic kidneys...
June 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27105914/high-glucose-induced-matrilin-2-expression-in-mouse-mesangial-cells-was-mediated-by-transforming-growth-factor-beta-1-tgf-%C3%AE-1
#14
Shukun Zhang, Menglan Zhang, Hong Huang, Shiying Zhou, Yanshneg Du, Xin Yi, Junming Luo
This study aimed at evaluating the effect of high glucose on the expression of extracellular matrix (ECM) protein Matrilin-2 and the mechanism underlying this effect by using a mouse mesangial cell line. Mouse mesangial cells (MMCs) were cultured in media containing normal (5 mM d-glucose) or high concentrations of glucose (30 mM d-glucose). The expression of Matrilin-2 was assessed by either RT-PCR or western blot. Additionally, transforming growth factor beta 1 (TGF-β1) inhibitors and TGF-β1 were used to determine whether glucose-regulated Matrilin-2 expression was mediated by the TGF-β1/Smad3 signaling pathway...
May 27, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27041999/eucommia-bark-du-zhong-improves-diabetic-nephropathy-without-altering-blood-glucose-in-type-1-like-diabetic-rats
#15
Ho-Shan Niu, I-Min Liu, Chiang-Shan Niu, Po-Ming Ku, Chao-Tien Hsu, Juei-Tang Cheng
BACKGROUND: Eucommia bark, Eucommia ulmoides Oliver barks (Du-Zhong in Mandarin), is an herb used for renal dysfunction in Chinese traditional medicine. In an attempt to develop this herb as a treatment for diabetic nephropathy (DN), we investigated the effects of Du-Zhong on renal dysfunction in type 1-like diabetic rats. METHODS: Streptozotocin (STZ) was used to induce type 1-like diabetes in rats (STZ-diabetic rats). In addition to hyperglycemia, STZ-diabetic rats showed significant nephropathy, including higher plasma levels of blood urea nitrogen, creatinine, and renal fibrosis...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/26974954/role-of-igfbp7-in-diabetic-nephropathy-tgf-%C3%AE-1-induces-igfbp7-via-smad2-4-in-human-renal-proximal-tubular-epithelial-cells
#16
Jun Watanabe, Yumi Takiyama, Jun Honjyo, Yuichi Makino, Yukihiro Fujita, Masatoshi Tateno, Masakazu Haneda
Tubular injury is one of the important determinants of progressive renal failure in diabetic nephropathy (DN), and TGF-β1 has been implicated in the pathogenesis of tubulointerstitial disease that characterizes proteinuric renal disease. The aim of this study was to identify novel therapeutic target molecules that play a role in the tubule damage of DN. We used an LC-MS/MS-based proteomic technique and human renal proximal epithelial cells (HRPTECs). Urine samples from Japanese patients with type 2 diabetes (n = 46) were used to quantify the candidate protein...
2016: PloS One
https://www.readbyqxmd.com/read/26849902/tgf-%C3%AE-the-connecting-link-between-nephropathy-and-fibrosis
#17
Brijesh Sutariya, Dimple Jhonsa, Madhusudan N Saraf
Renal fibrosis is the usual outcome of an excessive accumulation of extracellular matrix (ECM) that frequently occurs in membranous and diabetic nephropathy. The result of renal fibrosis would be end-stage renal failure, which requires costly dialysis or kidney transplantation. Renal fibrosis typically results from chronic inflammation via production of several molecules, such as growth factors, angiogenic factors, fibrogenic cytokines, and proteinase. All of these factors can stimulate excessive accumulation of ECM components through epithelial to mesenchymal transition (EMT), which results in renal fibrosis...
February 2016: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/26770646/reduced-beta-2-glycoprotein-i-improve-diabetic-nephropathy-via-inhibiting-tgf-%C3%AE-1-p38-mapk-pathway-retraction
#18
(no author information available yet)
[This retracts the article on p. 6852 in vol. 8, PMID: 26221223.].
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26512931/protective-effects-of-leflunomide-on-renal-lesions-in-a-rat-model-if-diabetic-nephropathy
#19
Qing Zhang, Yongqiang Ji, Wei Lv, Tianwei He, Jianping Wang
Diabetic nephropathy is one of the most common chronic complications of diabetes with poor efficacy of clinical treatment. This study investigated the protective effects of leflunomide, a new immunosuppressant, on tubulointerstitial lesions in a rat model of diabetic nephropathy. Diabetes was induced with streptozotocin (STZ, 50 mg/kg) by intraperitoneal injection in male Wistar rats. Two weeks after STZ injection, diabetic rats were treated daily for 8 weeks with low (5 mg/kg) and high dose (10 mg/kg) of leflunomide, and benazepril hydrochloride (4 mg/kg) as a positive control...
2016: Renal Failure
https://www.readbyqxmd.com/read/26362188/branched-chain-amino-acids-attenuate-early-kidney-injury-in-diabetic-rats
#20
Na Mi, Xiu Juan Zhang, Yan Ding, Guo Hua Li, Wei Dong Wang, Hui Xia Xian, Jin Xu
Diabetic nephropathy (DN) is the most severe diabetic microvascular complication. The pathogenesis of diabetic nephropathy is complex, and oxidative stress plays an important role in the development of diabetic nephropathy. Elevated reactive oxygen species (ROS) levels activate various signaling pathways and influence the activities of transforming growth factor-β (TGF-β) and matrix metalloproteinase-9 (MMP-9), which contributes to glomerular hypertrophy. Branched-chain amino acids (BCAAs) are widely used in clinical treatment, and BCAAs can reduce the oxidative stress associated with the diabetic pancreas and some liver diseases...
October 16, 2015: Biochemical and Biophysical Research Communications
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