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https://www.readbyqxmd.com/read/28543991/sensitivity-and-specificity-of-plasma-alt-alp-and-bile-acids-for-hepatitis-in-labrador-retrievers
#1
K Dirksen, I A Burgener, J Rothuizen, T S G A M van den Ingh, L C Penning, B Spee, H Fieten
BACKGROUND: Biochemical indicators for diagnosing liver disease are plasma alanine aminotransferase activity (ALT), alkaline phosphatase activity (ALP), and bile acid concentration (BA). OBJECTIVES: To determine the sensitivity and specificity of ALT, ALP, and BA for detecting primary hepatitis (PH) in clinically healthy Labrador retrievers and investigate whether ALT and ALP can discriminate between dogs with PH and nonspecific reactive hepatitis (RH). ANIMALS: 191 clinically healthy and 51 clinically ill Labrador retrievers with hepatic histopathology...
May 23, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28541785/long-term-follow-up-consultation-after-childhood-cancer-in-the-rh%C3%A3-ne-alpes-region-of-france-feedback-from-adult-survivors-and-their-general-practitioners
#2
Claire Berger, Léonie Casagranda, Cécile Faure-Conter, Claire Freycon, Florentina Isfan, Aurélie Robles, Béatrice Trombert-Paviot, Isabelle Guichard, Isabelle Durieu, Pascal Cathebras
PURPOSE: We evaluated the satisfaction of adult survivors of childhood cancers and their general practitioners (GP) after a long-term consultation. METHODS: The first Long-term Follow-up Study in Oncology (SALTO1) is a prospective cohort study of survivors of childhood cancers (except leukemia) diagnosed between 1987 and 1992 in the Rhône-Alpes and Auvergne regions of France. Of the 481 patients eligible for the study, 150 participated in a long-term consultation with a pediatric oncologist and an internist, after which survivors and their GPs received long-term plans and recommendations based on consultation findings...
May 25, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28539746/protective-effect-of-sorrel-extract-on-adult-rats-treated-by-carbon-tetrachloride
#3
Abdullah Glil Alkushi
CONTEXT: Heart, kidneys, and liver are the vital organs present in vertebrates and some other animals. They have a wide range of functions, such as maintaining homeostasis, detoxification, protein synthesis, and production of biochemical, that are necessary for digestion and maintaining circulation. These organs are necessary for the survival, and currently, there are no means to compensate for the absence of their functionalities in a long term. The damage of liver can affect other vital organs, including kidneys and heart...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28539743/hepatoprotective-antihyperlipidemic-and-anti-inflammatory-activity-of-moringa-oleifera-in-diabetic-induced-damage-in-male-wistar-rats
#4
Elizabeth I Omodanisi, Yapo G Aboua, Novel N Chegou, Oluwafemi O Oguntibeju
BACKGROUND: The number of individuals with diabetes is increasing daily, and diabetes is presently estimated to affect about 422 million adults worldwide. Conventional drugs used to treat diabetes are not without severe side effects, accessibility, and affordability. This study elucidates the potential effects of Moringa oleifera (MO) leaves extract to manage and treat diabetes induced in male Wistar rats. MATERIALS AND METHODS: Adult male Wistar rats were randomly divided into four groups (n = 12/group): NC - nondiabetic rats (positive control), MO - nondiabetic-treated rats, DM - diabetic rats (negative control), DM + MO - diabetic-treated rats...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28537482/programmed-platelet-derived-growth-factor-%C3%AE-%C3%AE-and-bone-morphogenetic-protein-2-delivery-from-a-hybrid-calcium-phosphate-alginate-scaffold
#5
Emily A Bayer, Jahnelle Jordan, Riccardo Gottardi, Morgan Fedorchak, Prashant N Kumta, Steven Little
Bone tissue engineering requires the upregulation of several regenerative stages, including a critical early phase of angiogenesis. Previous studies have suggested that a sequential delivery of PDGF to BMP-2 could promote angiogenic tubule formation when delivered to in vitro co-cultures of human umbilical vein endothelial cells (HUVECs) and human mesenchymal stem cells (hMSCs). However, it was previously unclear that this PDGF to BMP-2 delivery schedule will result in cell migration into the scaffolding system and affect the later expression of bone markers...
May 24, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28537341/no-associations-of-25-hydroxycholecalciferol-and-parathyroid-hormone-concentrations-with-calcaneal-bone-characteristics-in-community-dwelling-elderly-subjects-a-cross-sectional-study
#6
A Jungert, M Neuhäuser-Berthold
OBJECTIVE: This study examined the associations of 25-hydroxycholecalciferol [25(OH)D3] and intact parathyroid hormone (iPTH) concentrations with bone status parameters in elderly subjects. DESIGN/SETTING: Cross-sectional data based on the follow-up 2008 of the longitudinal study on nutrition and health status of senior citizens in Giessen, Germany. PARTICIPANTS: One hundred eighty-eight independently living subjects aged 66-96 years. MEASUREMENTS: Serum concentrations of 25(OH)D3, iPTH, N-terminal propeptide of type 1 collagen (P1NP) and activity of alkaline phosphatase (ALP) were assessed...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28537241/-fibroblast-growth-factor-receptor-1-propagates-estrogen-and-fluid-shear-stress-driven-proliferation-and-differentiation-response-in-mc3t3-e1-cells
#7
J Y Li, S G Liu, G N Xiao, M Y Mao, X W Zhang, H Q Sun
Fluid shear stress (FSS) and estrogen exposure positively regulate bone metabolism. Fibroblast growth factor receptor 1 (FGFR1) plays a vital role in FSS-induced osteogenesis. An in vitro experiment with MC3T3-E1 cells combined with microarray analysis aided us in identification of the genes differentially expressed in response to FSS and highlighted the role of FGFR1 in this process. Both estrogen exposure and FSS increase methyl thiazol tetrazolium (MTT) values and alkaline phosphatase (ALP) activity, as well as the levels of Runt-related transcription factor 2 (Runx2) and osteocalcin (OCN)...
March 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28536848/ion-sensor-properties-of-fluorescent-schiff-bases-carrying-dipicolylamine-groups-a-simple-spectrofluorimetric-method-to-determine-cu-ii-in-water-samples
#8
Elvan Vanlı, Miraç Nedim Mısır, Hakan Alp, Tuğba Ak, Nurhayat Özbek, Ümmühan Ocak, Miraç Ocak
Four fluorescent Schiff bases carrying dipicolylamine groups were designed and synthesized to determine their ion sensor properties in partial aqueous solution. The corresponding amine compound and the aldehyde compounds such as 1-naphthaldehyde, 9-anthraldehyde, phenanthrene-9-carboxaldehyde and 1-pyrenecarboxaldehyde were used to prepare the new Schiff bases. The influence of many metal cations and anions on the spectroscopic properties of the ligands was investigated in ethanol-water (1:1) by means of emission spectrometry...
May 23, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/28535741/effects-of-n-acetyl-cysteine-on-oxidative-stress-and-tnf-%C3%AE-gene-expression-in-diclofenac-induced-hepatotoxicity-in-rats
#9
Ali Nouri, Esfandiar Heidarian, Morteza Nikoukar
The consumption of nonsteroidal anti-inflammatory drug, such as diclofenac, can lead to hepatotoxicity. In the present study, protective effect of N-acetyl cysteine (NAC) on diclofenac-induced hepatotoxicity was investigated. Thirty two male rats were divided into four groups. Group 1 (control group) was treated with normal saline (1 ml/kg, i.p.) for 4 days. Group 2 (test without treatment) received diclofenac only (50 mg/kg, i.p.) for 4 days. Groups 3 and 4 received diclofenac (50 mg/kg, i.p.) plus NAC (150mg/kg, p...
May 24, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28534828/how-ketamine-affects-livers-of-pregnant-mice-and-developing-mice
#10
Hoi Man Cheung, Tony Chin Hung Chow, David Tai Wai Yew
It is well known that ketamine abuse can induce liver damage in adult addicts, but the effects of ketamine abuse in pregnant mothers on their offspring have received less attention. In this study, we investigated the effects of 5-day ketamine injections (30 mg/kg) to pregnant Institute for Cancer Research (ICR) mice during early gestation or mid-gestation on the aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities of the mothers and the offspring. We also looked into whether administering ketamine treatment to the mothers had any effects on the extent of fibrosis, cell proliferation and cell death in the livers of the newborns...
May 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28533792/retrospective-analysis-of-wood-anatomical-traits-reveals-a-recent-extension-in-tree-cambial-activity-in-two-high-elevation-conifers
#11
Marco Carrer, Daniele Castagneri, Angela L Prendin, Giai Petit, Georg von Arx
The study of xylogenesis or wood formation is a powerful, yet labor intensive monitoring approach to investigate intra-annual tree growth responses to environmental factors. However, it seldom covers more than a few growing seasons, so is in contrast to the much longer lifespan of woody plants and the time scale of many environmental processes. Here we applied a novel retrospective approach to test the long-term (1926-2012) consistency in the timing of onset and ending of cambial activity, and in the maximum cambial cell division rate in two conifer species, European larch and Norway spruce at high-elevation in the Alps...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28533732/e-cadherin-and-fgfr1-expression-in-mouse-osteoblastogenesis-in-normoxic-cultures
#12
Osama Al-Amer
E-cadherin is a cell surface adhesion molecules that play an important role in tissue differentiation. FGFR1 is expressed in the developing and mature skeleton in patterns suggestive of both unique and redundant function. Expression levels of E-cadherin and FGFR1 during osteoblastogenesis unclear. In this study primary calvarial mouse osteoblasts were differentiated to mature osteoblasts in osteogenic medium. Alkaline phosphatase (ALP) activity, alizarin red staining, gene expression (Runt-related transcription factor 2 (Runx2), collagen 1 (COL1A2), osteocalcin, E-cadherin and FGFR1) and protein expression (E-cadherin and FGFR1) of osteogenic-cultured primary mouse osteoblast were analysed in this study...
March 2017: International Journal of Biomedical Science: IJBS
https://www.readbyqxmd.com/read/28533546/prostaglandin-e2-inhibits-matrix-mineralization-by-human-bone-marrow-stromal-cell-derived-osteoblasts-via-epac-dependent-camp-signaling
#13
Ali Mirsaidi, André N Tiaden, Peter J Richards
The osteoinductive properties of prostaglandin E2 (PGE2) and its signaling pathways have led to suggestions that it may serve as a potential therapeutic strategy for bone loss. However, the prominence of PGE2 as an inducer of bone formation is attributed primarily to findings from studies using rodent models. In the current study, we investigated the effects of PGE2 on human bone marrow stromal cell (hBMSC) lineage commitment and determined its mode of action. We demonstrated that PGE2 treatment of hBMSCs significantly altered the expression profile of several genes associated with osteoblast differentiation (RUNX2 and ALP) and maturation (BGLAP and MGP)...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28532993/canine-leptospirosis-in-switzerland-a-prospective-cross-sectional-study-examining-seroprevalence-risk-factors-and-urinary-shedding-of-pathogenic-leptospires
#14
Alessandro Delaude, Sabrina Rodriguez-Campos, Anou Dreyfus, Michel Jacques Counotte, Thierry Francey, Ariane Schweighauser, Sophie Lettry, Simone Schuller
Leptospirosis is an important worldwide zoonosis. While human leptospirosis remains rare in Switzerland, the incidence of canine leptospirosis is unusually high compared to other European countries. The aims of this cross-sectional study were to determine the exposure of asymtomatic dogs to pathogenic Leptospira in Switzerland, to characterise risk factors associated with seropositivity and to determine the prevalence of urinary shedding. Sampling was stratified to cover the whole of Switzerland. Sera were tested by microscopic agglutination test for antibodies against a panel of 12 serovars...
June 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28532222/bromuconazole-induced-hepatotoxicity-is-accompanied-by-upregulation-of-pxr-cyp3a1-and-downregulation-of-car-cyp2b1-gene-expression
#15
Doaa H Abdelhady, Mohammed A El-Magd, Zizy I Elbialy, Ayman A Saleh
Despite widespread use of bromuconazole as a pesticide for food crops and fruits, limited studies have been done to evaluate its toxic effects. Here, we evaluated the hepatotoxic effect of bromuconazole using classical toxicological (biochemical analysis and histopathological examination) and gene-based molecular methods. Male rats were treated either orally or topically with bromuconazole at doses equal to no observed adverse effect level (NOAEL) and 1/10 LD50 for 90 days. Bromuconazole increased activities of liver enzymes (ALT, AST, ALP, and ACP), and levels of bilirubin...
May 23, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28531998/reline-assisted-green-and-facile-synthesis-of-fluorapatite-nanoparticles
#16
Mohammad Karimi, Majid Rastegar Ramsheh, Seyed Mohammad Ahmadi, Mohammad Reza Madani, Mehdi Shamsi, Reyhaneh Reshadi, Farahnaz Lotfi
A fast, simple and sustainable method based on choline chloride-urea deep eutectic solvent (known as Reline) was employed to synthesize nanosized fluorapatite (FA) particles. Using XRD, FESEM, TEM, EDS, and FTIR, the formation of FA nanoparticles with average crystal size of ~34nm, percent crystallinity of 93%, particle size of ~45nm, and high crystal, elemental, and structural purity was confirmed. The MTT cytotoxicity assay endorsed the non-toxicity of as-synthesized FA nanoparticles. The good biocompatibility, osteogenity and mineralization ability of as-synthesized FA nanoparticles were confirmed by Alizarin red staining, Acridine orange staining and ALP activity tests...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531995/scavenging-free-radicals-and-soaring-osteoinduction-by-extra-cellular-matrix-protein-based-nanocomposites-on-degenerative-bone-treatments
#17
Kavitha Kandiah, Navaneethan Duraisamy, Vinoth Amirthalingam, Balagurunathan Ramasamy
A number of materials are now available to alleviate the ever-growing bone disruption. However, these are inadequate and inappropriate for addressing issues associated natural process of aging and degeneration of bone due to diseases. This study advances the existing material and offers more privileged and synergistically active remedy for these conditions. Here, they are three different nano-composites prepared such as nano-TiO2 with chitosan (TC), nano-TiO2 with chondroitin 4-sulfate (TG), and nano-TiO2 with chitosan and chondroitin 4-sulfate (TCG), whereas nano-TiO2 act as a control...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531958/unique-postglacial-evolution-of-the-hornbeam-carpinus-betulus-l-in-the-carpathians-and-the-balkan-peninsula-revealed-by-chloroplast-dna
#18
Dragoş Postolache, Flaviu Popescu, Ladislav Paule, Dalibor Ballian, Peter Zhelev, Sorina Fărcaş, Juraj Paule, Ovidiu Badea
The Balkan Peninsula is one of the largest and most important European glacial refugia. However, the evolutionary history and phylogeographic pattern of temperate tree species that survived in the Balkans glacial refugia and their contribution to the genetic structure of the current population in the Carpathian Mountains remains poorly understood. Using polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP), and extensive population sampling, we explored the phylogeographic pattern of Carpinus betulus in both the Balkan Peninsula and the Carpathian region...
May 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28531878/effect-of-hierarchical-pore-structure-on-alp-expression-of-mc3t3-e1-cells-on-bioglass-films
#19
Cuixia Yu, Junjun Zhuang, Lingqing Dong, Kui Cheng, Wenjian Weng
Hierarchical porous bioglass films on the tantalum were designed to enhance osteointegration of metallic implants. The films were prepared by a sol-gel method using P123 as the mesopore template and polystyrene microsphere as the nanopore template. The films with 5.4nm mesopores and 100nm nanopores (MBG-100) elicited an obviously elongated morphology of the cultured MC3T3-E1 cells, as a result, a higher alkaline phosphatase level was expressed. It is suggested that the nanopores play an important role in regulating cellular behavior by initial protein adsorption through nanopore curvatures...
May 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28531166/-epiafzelechin-protects-against-ovariectomy-induced-bone-loss-in-adult-mice-and-modulate-osteoblastic-and-osteoclastic-functions-in-vitro
#20
Ka-Chun Wong, Sisi Cao, Xiaoli Dong, Man-Chun Law, Tak-Hang Chan, Man-Sau Wong
The present study was designed to characterize the bone protective effects of (-)-epiafzelechin (EAF), a flavan-3-ol, in mature ovariectomized mice model and its ability to stimulate osteoblastic activity and inhibit osteoclastic activity. Mature C57BL/6 mice (three to four months old) were either ovariectomised (OVX) or sham-operated and subjected to treatment (vehicle, 17β-oestradiol (E2, 200 μg/kg/day) or EAF (500 μg/kg/day) orally for six weeks. EAF and E2 significantly reduced urinary calcium (Ca) excretion, serum osteocalcin (OCN), and urinary deoxy-pyridinoline (DPD); increased bone mineral density (BMD); and improved micro-architectural properties in OVX mice...
May 22, 2017: Nutrients
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