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https://www.readbyqxmd.com/read/29684776/cyclic-uniaxial-compression-of-human-stem-cells-seeded-on-a-bone-biomimetic-nanocomposite-decreases-anti-osteogenic-commitment-evoked-by-shear-stress
#1
Walter Baumgartner, Isabelle Schneider, Samuel C Hess, Wendelin J Stark, Sonja Märsmann, Marzia Brunelli, Maurizio Calcagni, Paolo Cinelli, Johanna Buschmann
OBJECTIVE: Chemical supplementation of culture media to induce differentiation of adult stem cells seeded on a scaffold may mask other differentiation triggers such as scaffold stiffness, chemical composition or mechanical stimulation. However, stem cells can be differentiated towards osteoblasts without any supplementation given an appropriate osteogenic scaffold and an adequate mechanical stimulation. MATERIALS AND METHODS: Electrospun meshes of poly-lactic-co-glycolic acid and amorphous calcium phosphate nanoparticles (PLGA/aCaP) in a weight ratio of 60:40 were seeded with human adipose-derived stem cells (ASCs) and cultured in DMEM...
April 5, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29684600/effect-of-high-dietary-starch-levels-on-growth-hepatic-glucose-metabolism-oxidative-status-and-immune-response-of-juvenile-largemouth-bass-micropterus-salmoides
#2
Shi-Mei Lin, Chao-Ming Shi, Ming-Ming Mu, Yong-Jun Chen, Li Luo
An experimental trial was conducted to investigate the effects of high dietary starch levels on growth, hepatic glucose metabolism enzyme, antioxidant capacity and immune responses of largemouth bass, Micropterus salmoides. Fish (initial body weight: 16.9 ± 0.24 g) were fed three isonitrogenous and isoenergetic semi-purified diets containing 5%, 10% and 20% wheat starch, respectively. The results indicated that fish fed 5% and 10% starch diets showed significantly better weight gain, specific growth rate (SGR), protein efficiency ratio (PER) and feed conversion ratio (FCR) compared with that fed 20% starch diet...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684242/age-related-differences-in-reperfusion-therapy-and-outcomes-for-st-segment-elevation-myocardial-infarction
#3
Julien Turk, Magali Fourny, Komlavi Yayehd, Nicolas Picard, François-Xavier Ageron, Bastien Boussat, Loïc Belle, Gérald Vanzetto, Etienne Puymirat, José Labarère, Guillaume Debaty
OBJECTIVES: To compare timely access to reperfusion therapy and outcomes according to age of older adults with ST-segment elevation myocardial infarction (STEM) managed within an integrated regional system of care. DESIGN: Ongoing, prospective, regional, hospital-based clinical registry. SETTING: Twenty-three public and private hospitals in the Northern Alps in France. PARTICIPANTS: Individuals presenting with STEMI evolving for less than 12 hours from symptom onset between January 2009 and December 2015 (N=4,813; 3,716 (77...
April 23, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29683727/bone-turnover-markers-and-novel-biomarkers-in-lung-cancer-bone-metastases
#4
Jiangli Lang, Qian Zhao, Yuedong He, Xijie Yu
CONTEXT: Lung cancer still remains the leading cause of cancer-related mortality worldwide. Bone is one of preferred metastatic sites for lung cancer cells. So far, both accurate diagnosis and effective treatment of lung cancer bone metastases are difficult. OBJECTIVE: This review aimed to evaluate roles of bone turnover markers (BTMs), microRNAs (miRNAs), dickkopf1 (DKK1) and insulin like growth factor binding protein 3 (IGFBP-3) in lung cancer bone metastases...
April 23, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29683655/alkaline-phosphatase-assay-based-on-the-chromogenic-interaction-of-diethanolamine-with-4-aminophenol
#5
Jian Sun, Jiahui Zhao, Xingfu Bao, Qifeng Wang, Xiurong Yang
Diethanolamine (DEA) has been extensively utilized as an alkaline buffer in current assays of alkaline phosphatase (ALP) activity in the past decades. While playing the role of a buffer, DEA has been widely ignored about its chemical reactivity in such assays. Herein, we report an interesting chromogenic interaction between DEA and 4-aminophenol (AP) in the presence of H2 O for the first time, which inspires us to develop a novel DEA-participated ALP activity assay by using 4-aminophenyl phos-phate (APP) as a substrate...
April 23, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29682404/possible-association-of-multicentric-castleman-s-disease-with-autoimmune-lymphoproliferative-syndrome
#6
REVIEW
Hiroyuki Minemura, Yoshinori Tanino, Kazuhiko Ikeda
Multicentric Castleman's disease (MCD) is lymphoproliferative disorder characterized by systemic inflammatory symptoms such as fever and weight loss. Human herpes virus-8 (HHV-8) is thought to be a causable pathogen in all HIV-positive and some HIV-negative MCD patients. Furthermore, the term idiopathic MCD (iMCD) was recently proposed to represent a group of HIV-negative and HHV-8-negative patients with unknown etiologies. Although the international diagnostic criteria for iMCD require exclusion of infection-related disorders, autoimmune/autoinflammatory diseases and malignant/lymphoproliferative disorders to make an iMCD diagnosis, the relationships and differences between these disorders and MCD have not yet been clarified...
2018: BioResearch Open Access
https://www.readbyqxmd.com/read/29681666/impact-of-dietary-phosphorous-in-diploid-and-triploid-atlantic-salmon-salmo-salar-l-with-reference-to-early-skeletal-development-in-freshwater
#7
M A Smedley, H Migaud, E L McStay, M Clarkson, P Bozzolla, P Campbell, J F Taylor
In order to assess the effect of dietary phosphorus (P) in reducing vertebral malformations and improving freshwater (FW) performance in triploid Atlantic salmon ( Salmo salar ), both triploid and diploid Atlantic salmon were fed three different dietary P inclusion levels (low: 4.9, medium: 7.7, and high: 9.7 g available P kg-1 ) from first feeding until smolt. Somatic and skeletal response was assessed at fry (~0.5 g), parr (~5 g) and smolt (~45 g) stages. Triploid parr initially grew faster on the high P diet, while groups fed low P resulted in a significantly higher weight at smolt...
March 1, 2018: Aquaculture
https://www.readbyqxmd.com/read/29680724/human-dental-pulp-cells-express-cellular-markers-for-inflammation-and-hard-tissue-formation-in-response-to-bacterial-information
#8
Akina Sugiuchi, Yousuke Sano, Masahiro Furusawa, Shu Abe, Takashi Muramatsu
INTRODUCTION: Lipopolysaccharide (LPS) is a major component of the outer membranes of gram-negative bacteria associated with deep dental caries and pulpitis. When bacteria invade dentinal tubes and dentin is continually destroyed, tertiary dentin is formed by preexisting odontoblasts. However, the relationship between LPS and tertiary dentin formation remains unclear. We investigated whether LPS stimulation induces the formation of hard tissue in human dental pulp cells (hDPCs). METHODS: Immortalized hDPCs were cultured, and Escherichia coli-derived LPS (1 μg/mL) was incorporated into the culture medium...
April 18, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29679609/cannabis-sativa-marijuana-alters-blood-chemistry-and-the-cytoarchitecture-of-some-organs-in-sprague-dawley-rat-models
#9
Nosarieme Omoregie Abey
There is evidence that Cannabis whose active ingredient is tetrahydrocannabinol (THC) is the most commonly abused neuroactive substance, among young adults. This work investigated the effects of Cannabis sativa on the cytoarchitecture of some key organs and the blood chemistry of rat models. Twenty-one (21) male Sprague Dawley rats were fed different percentage of cannabis chow (0%, 5% and 10%) for a period of seven (7) weeks. Rats were subjected to intermittent cognitive function test and sacrificed after the seventh week, collecting the blood, brain and other important tissues for analysis which include; brain total protein and nitric oxide concentration, blood chemistry and histopathology...
April 18, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29679229/compromised-alveolar-bone-cells-in-a-patient-with-dentinogenesis-imperfecta-caused-by-dspp-mutation
#10
Thantrira Porntaveetus, Nunthawan Nowwarote, Thanaphum Osathanon, Thanakorn Theerapanon, Prasit Pavasant, Lawan Boonprakong, Kittisak Sanon, Sirivimol Srisawasdi, Kanya Suphapeetiporn, Vorasuk Shotelersuk
OBJECTIVES: Dentin sialophosphoprotein (DSPP) plays an important role in the mineralization of both dentin and bones. The Dspp null mice developed periodontal diseases. Patients with DSPP mutations have dentinogenesis imperfecta (DGI), but very little is known about their bone characteristics. This study aims to characterize alveolar bone cells of a DGI patient with DSPP mutation. MATERIALS AND METHODS: Pathogenic variants were identified by whole exome and sanger sequencing...
April 20, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29678845/the-use-of-type-i-collagen-cross-linked-c-telopeptide-ctx-1-as-a-biomarker-associated-with-the-formation-of-periprosthetic-ossifications-following-total-hip-joint-arthroplasty
#11
Paweł Łęgosz, Łukasz Pulik, Piotr Stępiński, Jakub Janowicz, Agnieszka Wirkowska, Andrzej Kotela, Sylwia Sarzyńska, Paweł Małdyk
The aim of this study was to determine the co-occurrence of heterotopic ossifications (HO) and elevated bone biomarkers level (urine type I collagen cross-linked C-telopeptide - CTX-1, serum alkaline phosphatase - ALP) and assess the effectiveness of pharmacological prophylaxis of HO. The study group consisted of (N=54) patients qualified for total hip arthroplasty. In N=19 (35%) patients new HO were formed (48th week vs to baseline). On baseline, the mean CTX-1 value in the HO (-) patients was 8.60+/-5.37 ug/mmol vs HO (+) 11...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29677982/consequences-of-switching-to-blended-learning-the-grenoble-medical-school-key-elements
#12
Sahal Houssein, Lionel Di Marco, Carole Schwebel, Vanda Luengo, Patrice Morand, Pierre Gillois
INTRODUCTION: In 2006, the Grenoble-Alpes University Medical School decided to switch the learning paradigm of the first year to a blended learning model based on a flipped classroom with a continuous dual assessment system providing personal follow-up. We report a descriptive analysis of two pedagogical models. METHODS: The innovative blended learning model is divided into 5 week-sequences of learning, starting with a series of knowledge capsules, following with Interactive On Line Questions, Interactive On Site Training and an Explanation Meeting...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677546/bacitracin-promotes-osteogenic-differentiation-of-human-bone-marrow-mesenchymal-stem-cells-by-stimulating-the-bone-morphogenetic-protein-2-smad-axis
#13
Hui Li, Bin'en Nie, Zhe Du, Shutao Zhang, Teng Long, Bing Yue
Bacitracin, a widely used metallopeptide antibiotic, has been reported to be locally used in treating wounds without systemic adverse reactions. Our preliminary study showed that bacitracin might enhance the osteogenic differentiation of human bone marrow mesenchymal stem cells (HBMSCs). The present study investigated whether bacitracin affects the osteogenic differentiation of HBMSCs and the molecular mechanisms involved. The proliferation of HBMSCs in the presence of bacitracin was examined using a cell counting kit-8 (CCK-8) assay...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677542/innovative-perception-on-using-tiron-to-modulate-the-hepatotoxicity-induced-by-titanium-dioxide-nanoparticles-in-male-rats
#14
Ashraf Morgan, Marwa A Ibrahim, Mona K Galal, Hanan A Ogaly, Reham M Abd-Elsalam
The extensive application of titanium dioxide nanoparticles (TiO2 NPs) in the food industry arouses a debate regarding the probable risk associated with their use. Several recent studies reported that most nanoparticles (NPs) have adverse actions on the liver. The objective of this study is to examine whether Tiron plays a modulatory role against apoptotic damage induced by TiO2 NPs in rat livers. Forty rats were randomly divided into 4 groups; a control group received phosphate-buffered saline, an intoxicated group received 100 mg/kg/day of TiO2 NPs for 60 days, a treated group received 470 mg/kg/day of Tiron for the last 14 days after TiO2 NPs administration, and a Tiron group received Tiron only as previously mentioned...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677080/corm-401-reduces-ischemia-reperfusion-injury-in-an-ex-vivo-renal-porcine-model-of-the-donation-after-cardiac-death
#15
Rabindra N Bhattacharjee, Mahms Richard-Mohamed, Qizhi Sun, Aaron Haig, Ghaleb Aboalsamh, Peter Barrett, Richard Mayer, Ibrahim Alhasan, Karen Pineda-Solis, Larry Jiang, Hajed Alharbi, Manujendra Saha, Eric Patterson, Alp Sener, Gediminas Cepinskas, Anthony M Jevnikar, Patrick P W Luke
BACKGROUND: Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CORM-401 has recently been synthesized which can efficiently deliver 3 molar equivalents of CO. We report the ability of this anti-inflammatory CORM-401 to reduce ischemia reperfusion injury associated with prolonged cold storage of renal allografts obtained from donation after cardiac death in a porcine model of transplantation...
April 19, 2018: Transplantation
https://www.readbyqxmd.com/read/29677036/coupled-opg-fc-on-decellularized-aortic-valves-by-edc-nhs-attenuates-rat-mscs-calcification-in-vitro
#16
Qiao Zhang, Si Chen, Jiawei Shi, Fei Li, Xucong Shi, Xingjian Hu, Cheng Deng, Feng Shi, Guichun Han, Nianguo Dong
Valve calcification commonly damages natural human heart valves and tissue-engineered heart valves (TEHVs), and no ideal intervention is available in clinical practice. It is increasingly considered that osteoprotegerin (OPG) inhibits vascular calcification. We aimed to explore whether free OPG-Fc fusion protein or coupled OPG-Fc on decellularized aortic valves attenuates calcification. Calcification of rat bone marrow-derived mesenchymal stromal cells (MSCs) was induced by osteogenic differentiation media, and the effects of free OPG-Fc or OPG-Fc coupled on the decellularized porcine aortic heart valve leaflet scaffolds by coupling agents 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC)/N-hydroxysuccinimide (NHS) on calcification were observed...
April 18, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29675422/elucidation-on-predominant-pathways-involved-in-the-differentiation-and-mineralization-of-odontoblast-like-cells-by-selective-blockade-of-mitogen-activated-protein-kinases
#17
Jia Tang, Takashi Saito
Aim: To analyze the effect of three mitogen-activated protein kinase (MAPK) inhibitors, namely, SB202190 (p38 inhibitor), SP600125 (JNK inhibitor), and PD98059 (ERK inhibitor) in Dex-stimulated MDPC-23 cell differentiation and mineralization. Methods: Experiment was divided into five groups, control (cells without Dex and inhibitors treatment), Dex (cells with Dex treatment but without inhibitors), Dex + SB202190, Dex + SP600125, and Dex + PD98059. Cell differentiation was assessed by alkaline phosphatase (ALP) activity assay and real time RT-PCR...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29674896/deep-intraspecific-dna-barcode-splits-and-hybridisation-in-the-udea-alpinalis-group-insecta-lepidoptera-crambidae-an-integrative-revision
#18
Richard Mally, Peter Huemer, Matthias Nuss
The analysis of mitochondrial COI data for the European-Centroasian montane Udea alpinalis species group finds deep intraspecific splits. Specimens of U. austriacalis and U. rhododendronalis separate into several biogeographical groups. These allopatric groups are not recovered in the analyses of the two nuclear markers wingless and Elongation factor 1-alpha, except for U. austriacalis from the Pyrenees and the French Massif Central. The latter populations are also morphologically distinct and conspecific with Scopula donzelalis Guenée, 1854, which is removed from synonymy and reinstated as Udea donzelalis (Guenée, 1854) stat...
2018: ZooKeys
https://www.readbyqxmd.com/read/29674891/species-rediscovery-or-lucky-endemic-looking-for-the-supposed-missing-species-leistus-punctatissimus-through-a-biogeographer-s-eye-coleoptera-carabidae
#19
Pizzolotto Roberto, Brandmayr Pietro
Is it correct to look for a supposedly missing species by focusing research at the type locality? A species can be declared extinct because for an unusual amount of time it has not been seen again; however, in the frame of the climate change it is likely that a supposedly missing species is a lucky survivor not seen because it was not searched for in the correct environment. We used the strictly endemic Leistus punctatissimus Breit, 1914 (Coleoptera, Carabidae) as the case study for testing the latter hypothesis vs...
2018: ZooKeys
https://www.readbyqxmd.com/read/29674645/long-noncoding-rna-tug1-facilitates-osteogenic-differentiation-of-periodontal-ligament-stem-cells-via-interacting-with-lin28a
#20
Qin He, Shuangyan Yang, Xiuge Gu, Mengying Li, Chunling Wang, Fulan Wei
Periodontal ligament stem cells (PDLSCs) are mesenchymal stem cells derived from dental tissues with multidirectional differentiation potential and excellent self-renewing ability. Recently, long noncoding RNAs (lncRNAs) have been shown to play important roles in MSC osteogenic differentiation. In this study, we found that taurine upregulated gene 1 (TUG1), an evolutionarily conserved and widely present lncRNA was significantly upregulated in osteogenically induced PDLSCs compared to their undifferentiated counterparts...
April 19, 2018: Cell Death & Disease
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