keyword
MENU ▼
Read by QxMD icon Read
search

Il2

keyword
https://www.readbyqxmd.com/read/29684412/no-association-of-il2-il4-il6-tnf-and-ifng-gene-polymorphisms-was-found-with-taenia-solium-human-infection-or-neurocysticercosis-severity-in-a-family-based-study
#1
A Fleury, C Alaez, A Dessein, M Rosetti, B Saenz, M Hernández, R J Bobes, R Aquino, E Sciutto, C Gorodezky, G Fragoso
Neurocysticercosis (NC) is caused by the establishment of the metacestode stage of Taenia solium in the human central nervous system. A great heterogeneity in the susceptibility to the infection and to the disease has been reported. While the factors involved in this heterogeneity are not completely understood, clearly different immune-inflammatory profiles have been associated to each condition. This study evaluated the association of cytokine single nucleotide polymorphisms (SNPs) with susceptibility to infection and disease severity in NC patients...
April 20, 2018: Human Immunology
https://www.readbyqxmd.com/read/29618658/pancreatic-cancer-therapy-with-combined-mesothelin-redirected-chimeric-antigen-receptor-t-cells-and-cytokine-armed-oncolytic-adenoviruses
#2
Keisuke Watanabe, Yanping Luo, Tong Da, Sonia Guedan, Marco Ruella, John Scholler, Brian Keith, Regina M Young, Boris Engels, Suvi Sorsa, Mikko Siurala, Riikka Havunen, Siri Tähtinen, Akseli Hemminki, Carl H June
Pancreatic ductal adenocarcinoma (PDA) is characterized by its highly immunosuppressive tumor microenvironment (TME) that limits T cell infiltration and induces T cell hypofunction. Mesothelin-redirected chimeric antigen receptor T cell (meso-CAR T cell) therapy has shown some efficacy in clinical trials but antitumor efficacy remains modest. We hypothesized that combined meso-CAR T cells with an oncolytic adenovirus expressing TNF-α and IL-2 (Ad5/3-E2F-D24-TNFa-IRES-IL2, or OAd-TNFa-IL2) would improve efficacy...
April 5, 2018: JCI Insight
https://www.readbyqxmd.com/read/29607560/intrauterine-vaccination-induces-a-dose-sensitive-primary-humoral-response-with-limited-evidence-of-recall-potential
#3
Jonathan Alexander Pasternak, Glenn Hamonic, Jill Van Kessel, Colette L Wheler, Michael K Dyck, Heather L Wilson
PROBLEM: Induction of the local mucosal immune system within the reproductive tract is widely considered to be a key component in the development of effective prophylactic vaccines to control the spread of sexually transmitted infections. Here, we examine the capacity of the upper reproductive tract to act as a site of immune induction following. METHOD OF STUDY: Two vaccines formulated with a triple adjuvant combination and either recombinant bovine herpesvirus (tgD) protein or ovalbumin (OVA) were delivered at varying doses to the uterine lumen of rabbits and the resulting immune response evaluated after 32 days...
April 1, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29556342/receptor-targeted-aptamer-sirna-conjugate-directed-transcriptional-regulation-of-hiv-1
#4
Jiehua Zhou, Daniel Lazar, Haitang Li, Xin Xia, Sangeetha Satheesan, Paige Charlins, Denis O'Mealy, Ramesh Akkina, Sheena Saayman, Marc S Weinberg, John J Rossi, Kevin V Morris
Gene-based therapies represent a promising therapeutic paradigm for the treatment of HIV-1, as they have the potential to maintain sustained viral inhibition with reduced treatment interventions. Such an option may represent a long-term treatment alternative to highly active antiretroviral therapy. Methods: We previously described a therapeutic approach, referred to as transcriptional gene silencing (TGS), whereby small noncoding RNAs directly inhibit the transcriptional activity of HIV-1 by targeting sites within the viral promoter, specifically the 5' long terminal repeat (LTR)...
2018: Theranostics
https://www.readbyqxmd.com/read/29544815/cd8-cxcr5-t-cells-in-tumor-draining-lymph-nodes-are-highly-activated-and-predict-better-prognosis-in-colorectal-cancer
#5
Jifu E, Feihu Yan, Zhengchun Kang, Liangliang Zhu, Junjie Xing, Enda Yu
Tumor-draining lymph nodes (TDLNs) are the primary sites of tumor antigen presentation, as well as the origin of metastasis in most cases. Hence, the type and function of immune cells in TDLNs are critical to the microenvironment and potentially affect the clinical outcome of the malignancy. CD8+ CXCR5+ T cells are recently described to present high effector functions in infectious diseases, but their role in colorectal cancer (CRC) remains unclear. In forty-four Stage III CRC patients, we examined the CD8+ CXCR5+ T cells in blood, tumor, and TDLN...
March 12, 2018: Human Immunology
https://www.readbyqxmd.com/read/29543810/identification-of-plasma-biomarkers-for-discrimination-between-tuberculosis-infection-disease-and-pulmonary-non-tuberculosis-disease
#6
Marco Pio La Manna, Valentina Orlando, Paolo Li Donni, Guido Sireci, Paola Di Carlo, Antonio Cascio, Francesco Dieli, Nadia Caccamo
We used the Luminex Bead Array Multiplex Immunoassay to measure cytokines, chemokines and growth factors responses to the same antigens used for RD1-based Interferon γ Release Assay (IGRA) test. Seventy-nine individuals, 27 active TB, 32 latent infection subsets, 20 individuals derivative purified protein (PPD) negative (subjects that do not have any indurative cutaneous reaction after 72 hrs of intradermal injection of PPD) and with other pulmonary disease were retrospectively studied. Forty-eight analytes were evaluated by Luminex Assay in plasma obtained from whole blood stimulated cells...
2018: PloS One
https://www.readbyqxmd.com/read/29535714/formulation-in-dda-mpla-tdb-liposome-enhances-the-immunogenicity-and-protective-efficacy-of-a-dna-vaccine-against-mycobacterium-tuberculosis-infection
#7
Maopeng Tian, Zijie Zhou, Songwei Tan, Xionglin Fan, Longmeng Li, Nadeem Ullah
Despite the vaccine Mycobacterium bovis Bacillus Calmette-Guérin is used worldwide, tuberculosis (TB) remains the first killer among infectious diseases. An effective vaccine is urgently required. DNA vaccine has shown prophylactic as well as therapeutic effects against TB, while its weak immunogenicity hinders the application. As a strong inducer of Th1-biased immune response, DMT, consisting of dimethyldioctadecylammonium (DDA) and two pattern recognition receptor agonists monophosphoryl lipid A and trehalose 6,6'-dibehenate (TDB), was a newly developed liposomal adjuvant...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29523510/engineered-il2-il2r%C3%AE-pairs-may-enhance-the-efficacy-of-t-cell-therapy
#8
(no author information available yet)
Orthogonal IL2/IL2Rβ pairs allow selective targeting of engineered autologously transferred T cells.
March 9, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29518260/inflammatory-intrathecal-profiles-and-cortical-damage-in-multiple-sclerosis
#9
R Magliozzi, O W Howell, R Nicholas, C Cruciani, M Castellaro, C Romualdi, S Rossi, M Pitteri, M D Benedetti, A Gajofatto, F B Pizzini, S Montemezzi, S Rasia, R Capra, A Bertoldo, F Facchiano, S Monaco, R Reynolds, M Calabrese
OBJECTIVE: Grey matter (GM) damage and meningeal inflammation have been associated with early disease onset and a more aggressive disease course in Multiple Sclerosis (MS), but can these changes be identified in the patient early in the disease course? METHODS: To identify possible biomarkers linking meningeal inflammation, GM damage and disease severity, gene and protein expression were analysed in meninges and CSF from 27 post-mortem secondary progressive MS (SPMS) and 14 control cases...
March 8, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29517678/the-clinical-significance-of-col5a2-in-patients-with-bladder-cancer-a-retrospective-analysis-of-bladder-cancer-gene-expression-data
#10
Xian-Tao Zeng, Xiao-Ping Liu, Tong-Zu Liu, Xing-Huan Wang
The present study was aimed to investigate the relationship between the expression of collagen type V alpha 2 chain (COL5A2) and clinical outcomes of patients with bladder cancer.Chi-square test and log-rank-based survival analysis were performed to assess the correlation of COL5A2 expression with clinical characteristics and survivals of patients with bladder cancer using GSE13507. Gene set enrichment analysis was conducted to study the relevant mechanisms.Bladder cancer patients in COL5A2 low expression group were associated with better invasiveness (P < ...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29517628/th1-and-th2-cytokine-profiles-as-predictors-of-severity-in-acute-pancreatitis
#11
Antonio Rodriguez-Nicolas, Alba Martínez-Chamorro, Pilar Jiménez, Ana M Matas-Cobos, Eduardo Redondo-Cerezo, Francisco Ruiz-Cabello
OBJECTIVES: Acute pancreatitis (AP) is severe in up to 20% of patients, with a high mortality rate. Quantification of serum TH1 and TH2 cytokines may provide objective evidence to assess the severity of AP and predict its course. METHODS: One hundred seventeen patients were studied, measuring serum concentrations of interleukin (IL)1β, IL2, IL4, IL5, IL6, IL10, IL12p70, IL13, IL18, granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon (IFN) γ, and tumor necrosis factor (TNF) α...
April 2018: Pancreas
https://www.readbyqxmd.com/read/29515759/nfat-mediated-defects-in-erythropoiesis-cause-anemia-in-il2-mice
#12
Sabrina Giampaolo, Gabriela Wójcik, Stefan Klein-Hessling, Edgar Serfling, Amiya K Patra
The role of NFAT family transcription factors in erythropoiesis is so far unknown, although their involvement has been suggested previously. We have shown recently that Il2 -/- mice develop severe anemia due to defects in KLF1 activity during BM erythropoiesis. Although, KLF1 activity is indispensable for erythropoiesis, the molecular details of Klf1 expression have not yet been elucidated. Here we show that an enhanced NFATc1 activity induced by increased integrin-cAMP signaling plays a critical role in the dysregulation of Klf1 expression and thereby cause anemia in Il2 -/- mice...
February 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29514797/cd16a-activation-of-nk-cells-promotes-nk-cell-proliferation-and-memory-like-cytotoxicity-against-cancer-cells
#13
Jens H W Pahl, Joachim Koch, Jana-Julia Gotz, Annette Arnold, Uwe Reusch, Thorsten Gantke, Erich Rajkovic, Martin S Treder, Adelheid Cerwenka
CD16A is a potent cytotoxicity receptor on human NK cells, which can be exploited by therapeutic bispecific antibodies. So far, the effects of CD16A-mediated activation on NK cell effector functions beyond classical antibody-dependent cytotoxicity have remained poorly elucidated. Here, we investigated NK cell responses after exposure to therapeutic antibodies such as the tetravalent bispecific antibody AFM13 (CD30/CD16A), designed for the treatment of Hodgkin lymphoma and other CD30+ lymphomas. Our results reveal that CD16A engagement enhanced subsequent IL2 and IL15¬-driven NK cell proliferation and expansion...
March 7, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29513758/a-systems-pharmacology-model-for-inflammatory-bowel-disease
#14
Violeta Balbas-Martinez, Leire Ruiz-Cerdá, Itziar Irurzun-Arana, Ignacio González-García, An Vermeulen, José David Gómez-Mantilla, Iñaki F Trocóniz
MOTIVATION: The literature on complex diseases is abundant but not always quantitative. This is particularly so for Inflammatory Bowel Disease (IBD), where many molecular pathways are qualitatively well described but this information cannot be used in traditional quantitative mathematical models employed in drug development. We propose the elaboration and validation of a logic network for IBD able to capture the information available in the literature that will facilitate the identification/validation of therapeutic targets...
2018: PloS One
https://www.readbyqxmd.com/read/29511032/amd3100-augments-the-efficacy-of-mesothelin-targeted-immune-activating-vic-008-in-mesothelioma-by-modulating-intratumoral-immunosuppression
#15
Binghao Li, Yang Zeng, Patrick M Reeves, Chongzhao Ran, Qiuyan Liu, Xiying Qu, Yingying Liang, Zhao Liu, Jianping Yuan, Pierre R Leblanc, Zhaoming Ye, Ann E Sluder, Jeffrey A Gelfand, Timothy A Brauns, Huabiao Chen, Mark C Poznansky
AMD3100 (plerixafor), a CXCR4 antagonist, has been demonstrated to suppress tumor growth and modulate intratumoral T-cell trafficking. However, the effect of AMD3100 on immunomodulation remains elusive. Here, we explored immunomodulation and antitumor efficacy of AMD3100 in combination with a previously developed mesothelin-targeted, immune-activating fusion protein, VIC-008, in two syngeneic, orthotopic models of malignant mesothelioma (MM) in immunocompetent mice. We showed that combination therapy significantly suppressed tumor growth and prolonged animal survival in two mouse models...
March 6, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29499557/a-new-composite-of-graphene-and-molecularly-imprinted-polymer-based-on-ionic-liquids-as-functional-monomer-and-cross-linker-for-electrochemical-sensing-6-benzylaminopurine
#16
Xudong Zhu, Yanbo Zeng, Zulei Zhang, Yiwen Yang, Yunyun Zhai, Hailong Wang, Lingyu Liu, Jian Hu, Lei Li
Molecularly imprinted polymers prepared using traditional functional monomers and cross-linkers exhibit slow binding kinetics, low electrocatalytic activity and adsorption capacity. Herein, we report a new composite of ionic liquid-based graphene and molecularly imprinted polymer (IL-GR-MIP) with high electrocatalytic activity and adsorption capacity to construct an effective electrochemical sensor for 6-benzylaminopurine (6-BAP). Our objective was to enhance the efficiency of the sensor by incorporating more IL in the MIP framework...
February 13, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29483127/sustained-persistence-of-il2-signaling-enhances-the-antitumor-effect-of-peptide-vaccines-through-t-cell-expansion-and-preventing-pd-1-inhibition
#17
Hussein Sultan, Takumi Kumai, Valentyna I Fesenkova, Aaron E Fan, Juan Wu, Hyun-Il Cho, Hiroya Kobayashi, Yasuaki Harabuchi, Esteban Celis
Peptide vaccines can be a successful and cost-effective way of generating T-cell responses against defined tumor antigens, especially when combined with immune adjuvants such as poly-IC. However, strong immune adjuvants can induce a collateral increase in numbers of irrelevant, non-specific T cells, which limits the effectiveness of the peptide vaccines. Here we report that providing prolonged IL2 signaling either in the form of IL2/anti-IL2 complexes or pegylated IL2 overcomes the competitive suppressive effect of irrelevant T cells, allowing the preferential expansion of antigen-specific T cells...
February 26, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29476788/induction-profiles-of-mrna-of-toll-like-receptors-and-cytokines-in-chickens-pre-exposed-to-low-pathogenic-avian-influenza-h9n2-virus-followed-by-challenge-with-highly-pathogenic-avian-influenza-h5n1-virus
#18
Sandeep Kumar Dash, Manoj Kumar, Jag Mohan Kataria, Shanmugasundaram Nagarajan, Chakradhar Tosh, Harshad V Murugkar, K Rajukumar, S Kalaiyarasu, D Senthil Kumar, Diwakar D Kulkarni
Herein, the induction of TLRs and cytokines in chickens pre-exposed to low pathogenic avian influenza H9N2 virus followed by challenge with highly pathogenic avian influenza (HPAI) H5N1 virus was studied. Four groups (1-4) of chickens inoculated with 106 EID50 of H9N2 virus were challenged with 106 EID50 of H5N1 virus on days 1, 3, 7 and 14 post H9N2 inoculation, respectively. In groups (1-4) TLRs and cytokines induction was studied in chicken PBMCs on day 3 post H5N1 challenge. In H5N1 control group TLRs (1, 2, 5 and 7) cytokines (IFNα, IFNβ, IFNγ, IL1β, IL2, IL4, IL8 and TGF β3) were down regulated...
February 21, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29476787/expression-kinetics-of-isg15-irf3-ifn%C3%AE-il10-il2-and-il4-genes-vis-a-vis-virus-shedding-tissue-tropism-and-antibody-dynamics-in-pprv-vaccinated-challenged-infected-sheep-and-goats
#19
Sajad Ahmad Wani, Amit Ranjan Sahu, Shikha Saxena, Kaushal Kishor Rajak, M Saminathan, Aditya Prasad Sahoo, Sonam Kanchan, Aruna Pandey, Bina Mishra, D Muthuchelvan, Ashok Kumar Tiwari, Bishnu Prasad Mishra, Raj Kumar Singh, Ravi Kumar Gandham
Here, we studied the in vivo expression of Th1 (IL2 and IFN gamma) and Th2 (IL4 and IL10) - cytokines and antiviral molecules - IRF3 and ISG15 in peripheral blood mononuclear cells in relation to antigen and antibody dynamics under Peste des petits ruminants virus (PPRV) vaccination, infection and challenge in both sheep and goats. Vaccinated goats were seropositive by 9 days post vaccination (dpv) while in sheep idiosyncratic response was observed between 9 and 14 dpv for different animals. Expression of PPRV N gene was not detected in PBMCs of vaccinated and vaccinated challenged groups of both species, but was detected in unvaccinated infected PBMCs at 9 and 14 days post infection...
February 21, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29467958/pharmacokinetic-properties-of-radiolabeled-mutant-interleukin-2v-a-pet-imaging-study
#20
Siddesh V Hartimath, Valeria Manuelli, Rolf Zijlma, Alberto Signore, Tapan K Nayak, Anne Freimoser-Grundschober, Christian Klein, Rudi A J O Dierckx, Erik F J de Vries
Interleukin-2 (IL2) is a cytokine that can stimulate cytotoxic immune cells to attack infected and malignant cells. Unfortunately, IL2 can also cause serious immune-related toxicity. Recently, a mutant of IL2 (IL2v) with abolished CD25 binding, increased plasma half-life and less toxicity was engineered. Unlike wild-type IL2 (wt-IL2), mutant IL2v does not bind to the α-subunit (CD25) of the high affinity IL2αβγ receptor, but only to its β and γ subunit. Here, we investigated the biological properties of IL2v and compared with the wt-IL2 using fluorine-18 and PET...
January 23, 2018: Oncotarget
keyword
keyword
92030
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"