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https://www.readbyqxmd.com/read/29225179/synthesis-of-novel-benzodioxane-midst-piperazine-moiety-decorated-chitosan-silver-nanoparticle-against-biohazard-pathogens-and-as-potential-anti-inflammatory-candidate-a-molecular-docking-studies
#1
C S Karthik, H M Manukumar, A P Ananda, S Nagashree, K P Rakesh, L Mallesha, Hua-Li Qin, S Umesha, P Mallu, N B Krishnamurthy
Nanoparticles (NPs) are currently being investigated along with the use of biodegradable polymer containing active agents in many areas of medicine for targeted applications. The present study was aimed to synthesize novel compound Benzodioxane midst piperazine (BP) and characterization of a BP decorated chitosan silver nanoparticles (BP*C@AgNPs) and shown effective against hazardous pathogens, and also having anti-inflammatory property. It was further evaluated for molecular docking proofs, and toxicity. The BP*C@AgNPs had spherical shape with size of 36...
December 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29216487/microplastics-increase-impact-of-treated-wastewater-on-freshwater-microbial-community
#2
Ester M Eckert, Andrea Di Cesare, Marie Therese Kettner, Maria Arias-Andres, Diego Fontaneto, Hans-Peter Grossart, Gianluca Corno
Plastic pollution is a major global concern with several million microplastic particles entering every day freshwater ecosystems via wastewater discharge. Microplastic particles stimulate biofilm formation (plastisphere) throughout the water column and have the potential to affect microbial community structure if they accumulate in pelagic waters, especially enhancing the proliferation of biohazardous bacteria. To test this scenario, we simulated the inflow of treated wastewater into a temperate lake using a continuous culture system with a gradient of concentration of microplastic particles...
December 4, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29214662/airborne-particulate-concentration-during-laser-hair-removal-a-comparison-between-cold-sapphire-with-aqueous-gel-and-cryogen-skin-cooling
#3
Edward V Ross, Gary S Chuang, Arisa E Ortiz, Scott A Davenport
BACKGROUND: High concentrations of sub-micron nanoparticles have been shown to be released during laser hair removal (LHR) procedures. These emissions pose a potential biohazard to healthcare workers that have prolonged exposure to LHR plume. OBJECTIVE: We sought to demonstrate that cold sapphire skin cooling done in contact mode might suppress plume dispersion during LHR. METHODS: A total of 11 patients were recruited for laser hair removal...
December 7, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29144386/creating-a-world-class-program-through-training-and-certification
#4
Ann Turner
The animal research field has gotten more sophisticated with the use of genetically engineered animals, biohazardous agents, and advanced technologies. Trained and competent personnel are a cornerstone of any animal care and use program. Individual career success is a combination of education, experience, continuing competence, professional development, and personal commitment. Integration of training and certification into programs demonstrate institutional commitment to quality research and enhance the program by providing staff with knowledge and training to address problems and situation that arise and to perform their job in a professional and effective manner...
November 16, 2017: Behavioral Sciences
https://www.readbyqxmd.com/read/29116537/critical-analysis-of-excessive-utilization-of-crude-protein-in-ruminants-ration-impact-on-environmental-ecosystem-and-opportunities-of-supplementation-of-limiting-amino-acids-a-review
#5
Imtiaz Hussain Raja Abbasi, Farzana Abbasi, Mohamed E Abd El-Hack, Mervat A Abdel-Latif, Rab N Soomro, Khawar Hayat, Mohamed A E Mohamed, Bello M Bodinga, Junhu Yao, Yangchun Cao
Protein quality plays a key role than quantity in growth, production, and reproduction of ruminants. Application of high concentration of dietary crude protein (CP) did not balance the proportion of these limiting amino acids (AA) at duodenal digesta of high producing dairy cow. Thus, dietary supplementation of rumen-protected AA is recommended to sustain the physiological, productive, and reproductive performance of ruminants. Poor metabolism of high CP diets in rumen excretes excessive nitrogen (N) through urine and feces in the environment...
November 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29082230/yeast-for-virus-research
#6
REVIEW
Richard Yuqi Zhao
Budding yeast (Saccharomyces cerevisiae) and fission yeast (Schizosaccharomyces pombe) are two popular model organisms for virus research. They are natural hosts for viruses as they carry their own indigenous viruses. Both yeasts have been used for studies of plant, animal and human viruses. Many positive sense (+) RNA viruses and some DNA viruses replicate with various levels in yeasts, thus allowing study of those viral activities during viral life cycle. Yeasts are single cell eukaryotic organisms. Hence, many of the fundamental cellular functions such as cell cycle regulation or programed cell death are highly conserved from yeasts to higher eukaryotes...
September 18, 2017: Microbial Cell
https://www.readbyqxmd.com/read/29042238/novel-strategy-for-immunomodulation-dissolving-microneedle-array-encapsulating-thymopentin-fabricated-by-modified-two-step-molding-technology
#7
Shiqi Lin, Bingzhen Cai, Guilan Quan, Tingting Peng, Gangtao Yao, Chune Zhu, Qiaoli Wu, Hao Ran, Xin Pan, Chuanbin Wu
Thymopentin (TP5) is commonly used in the treatment for autoimmune diseases, with a short plasma half-life (30 s) and a long treatment period (7 days to 6 months). It is usually administrated by syringe injection, resulting in compromised patient compliance. Dissolving microneedle array (DMNA) offers a superior approach for transdermal delivery of biological macromolecules, as it allows painless penetration through the stratum corneum and generates minimal biohazardous waste after dissolving in the skin. Despite recent advances in DMNA as a novel approach for transdermal drug delivery, problem of insufficient mechanical strength remains to be solved...
October 14, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29034325/collection-of-viable-aerosolized-influenza-virus-and-other-respiratory-viruses-in-a-student-health-care-center-through-water-based-condensation-growth
#8
Maohua Pan, Tania S Bonny, Julia Loeb, Xiao Jiang, John A Lednicky, Arantzazu Eiguren-Fernandez, Susanne Hering, Z Hugh Fan, Chang-Yu Wu
The dynamics and significance of aerosol transmission of respiratory viruses are still controversial, for the major reasons that virus aerosols are inefficiently collected by commonly used air samplers and that the collected viruses are inactivated by the collection method. Without knowledge of virus viability, infection risk analyses lack accuracy. This pilot study was performed to (i) determine whether infectious (viable) respiratory viruses in aerosols could be collected from air in a real world environment by the viable virus aerosol sampler (VIVAS), (ii) compare and contrast the efficacy of the standard bioaerosol sampler, the BioSampler, with that of the VIVAS for the collection of airborne viruses in a real world environment, and (iii) gain insights for the use of the VIVAS for respiratory virus sampling...
September 2017: MSphere
https://www.readbyqxmd.com/read/28931561/genetic-mimetics-of-mycobacterium-tuberculosis-and-methicillin-resistant-staphylococcus-aureus-as-verification-standards-for-molecular-diagnostics
#9
Edith Erika Machowski, Bavesh Davandra Kana
Molecular diagnostics have revolutionized the management of health care through enhanced detection of disease or infection and effective engagement into care. In recognition of this, the World Health Organization approved the rollout out of nucleic acid amplification technologies for identification of Mycobacterium tuberculosis using platforms such as GeneXpert MTB/RIF, the GenoType MTBDRplus Line Probe Assay and more recently, GeneXpert MTB/RIF Ultra. These assays can simultaneously detect tuberculosis infection and assess rifampicin resistance...
September 20, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28910420/role-of-the-central-lysine-cluster-and-scrapie-templating-in-the-transmissibility-of-synthetic-prion-protein-aggregates
#10
Bradley R Groveman, Gregory J Raymond, Katrina J Campbell, Brent Race, Lynne D Raymond, Andrew G Hughson, Christina D Orrú, Allison Kraus, Katie Phillips, Byron Caughey
Mammalian prion structures and replication mechanisms are poorly understood. Most synthetic recombinant prion protein (rPrP) amyloids prepared without cofactors are non-infectious or much less infectious than bona fide tissue-derived PrPSc. This effect has been associated with differences in folding of the aggregates, manifested in part by reduced solvent exclusion and protease-resistance in rPrP amyloids, especially within residues ~90-160. Substitution of 4 lysines within residues 101-110 of rPrP (central lysine cluster) with alanines (K4A) or asparagines (K4N) allows formation of aggregates with extended proteinase K (PK) resistant cores reminiscent of PrPSc, particularly when seeded with PrPSc...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28843417/evaluation-of-primitive-ground-water-supplies-as-a-risk-factor-for-the-development-of-major-waterborne-zoonosis-in-egyptian-children-living-in-rural-areas
#11
Hassan A Elfadaly, Nawal A Hassanain, Mohey A Hassanain, Ashraf M Barakat, Raafat M Shaapan
BACKGROUND: Endemic waterborne zoonosis frequently occurs in both developed and less developed countries. Thus, bio-surveillance of waterborne zoonosis is a "necessity" for the implementation of effective preventive public health measures in Egyptian rural areas. The primitive individual water supplies created by the rural agriculture population, primarily from ground water, usually maximize the customers' exposure to impurity pathogens via diffused humans and animal excreta or wastages...
August 23, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28831211/screening-method-for-staphylococcus-aureus-identification-in-subclinical-bovine-mastitis-from-dairy-farms
#12
Natapol Pumipuntu, Suphang Kulpeanprasit, Sirijan Santajit, Witawat Tunyong, Thida Kong-Ngoen, Woranich Hinthong, Nitaya Indrawattana
BACKGROUND: Staphylococcus aureus is one of the most important contagious bacteria causing subclinical bovine mastitis. This bacterial infection is commonly identified by determine the pathogen in bovine milk samples through conventional technique including coagulase test. However, this test has several disadvantages as low sensitivity, risk of biohazard, cost expensive, and limited preparation especially in local area. AIM: Aim of this study was to compare and assess the screening method, Mannitol fermentation test (Mannitol salt agar [MSA]), and deoxyribonuclease (DNase) test, for S...
July 2017: Veterinary World
https://www.readbyqxmd.com/read/28747970/reproductive-performance-of-genetically-engineered-mice-housed-in-different-housing-systems
#13
Shikha Yadav, Inderjeet Yadav, Kunal Pratap, Pradeep Kumar Tiwari, Vijay Pal Singh
The genetically engineered mice require special husbandry care and are mainly housed in Individually Ventilated Cage (IVC) systems and Static Micro Isolator Cages (SMIC) to minimize the risk for spreading undesirable microorganisms. However, the static micro isolation cage housing like SMIC are being replaced with IVC systems in many facilities due to a number of benefits like a higher density housing in limited space, better protection from biohazards and allergens and decreased work load due to decreased frequency of cage changing required in this system...
June 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/28689517/an-assessment-of-irish-farmers-knowledge-of-the-risk-of-spread-of-infection-from-animals-to-humans-and-their-transmission-prevention-practices
#14
M M Mahon, M C Sheehan, P F Kelleher, A J Johnson, S M Doyle
The aim of this study was to ascertain farmers' knowledge of the risk of spread of infection from animals to humans, and their transmission prevention practices. This was a survey of farmers who submitted material to Ireland's Regional Veterinary Laboratories in 2015. There was an 84% response rate (1044 farmers). Ninety per cent of farmers were not aware that infection can be acquired from apparently healthy animals. Over half were not aware that disease could be contracted from sick poultry or pets. Conversely, the knowledge of the risk to pregnant women of infection from birthing animals was high (88%)...
September 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28681077/direct-analysis-of-site-specific-n-glycopeptides-of-serological-proteins-in-dried-blood-spot-samples
#15
Na Young Choi, Heeyoun Hwang, Eun Sun Ji, Gun Wook Park, Ju Yeon Lee, Hyun Kyoung Lee, Jin Young Kim, Jong Shin Yoo
Dried blood spot (DBS) samples have a number of advantages, especially with respect to ease of collection, transportation, and storage and to reduce biohazard risk. N-glycosylation is a major post-translational modification of proteins in human blood that is related to a variety of biological functions, including metastasis, cell-cell interactions, inflammation, and immunization. Here, we directly analyzed tryptic N-glycopeptides from glycoproteins in DBS samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS) without centrifugation of blood samples, depletion of major proteins, desalting of tryptic peptides, and enrichment of N-glycopeptides...
August 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28662748/institutional-oversight-of-occupational-health-and-safety-for-research-programs-involving-biohazards
#16
Melissa C Dyson, Calvin B Carpenter, Lesley A Colby
Research with hazardous biologic materials (biohazards) is essential to the progress of medicine and science. The field of microbiology has rapidly advanced over the years, partially due to the development of new scientific methods such as recombinant DNA technology, synthetic biology, viral vectors, and the use of genetically modified animals. This research poses a potential risk to personnel as well as the public and the environment. Institutions must have appropriate oversight and take appropriate steps to mitigate the risks of working with these biologic hazards...
June 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28627636/formulation-and-characterization-of-egcg-for-the-treatment-of-superficial-bladder-cancer
#17
Katarzyna Dettlaff, Maciej Stawny, Magdalena Ogrodowczyk, Anna Jelińska, Waldemar Bednarski, Dorota Wątróbska-Świetlikowska, Rick W Keck, Omar A Khan, Ibrahim H Mostafa, Jerzy Jankun
In the United States, the annual incidence of bladder cancer is approximately 70,000 new cases, with a mortality rate of approximately 15,000/year. The most common subtype (70%) of bladder cancer is superficial, namely hte non-muscle invasive disease form limited to the urothelium. The rate of progression and recurrence is up to 40 and 70%, respectively. Urothelial cell carcinoma of the bladder is typically treated with transurethral resection. The cancerous cells can float onto the adjacent epithelium, increasing the risk of recurrence...
June 14, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28602947/radiation-exposure-from-depleted-uranium-the-radiation-bystander-effect
#18
Alexandra C Miller, Rafael Rivas, Leonard Tesoro, Gregor Kovalenko, Nikola Kovaric, Peter Pavlovic, David Brenner
Depleted uranium (DU) is a radioactive heavy metal used primarily in military applications. Published data from our laboratory have demonstrated that DU exposure in vitro to immortalized human osteoblast cells (HOS) is both neoplastically transforming and genotoxic. In vivo studies have also demonstrated that DU is leukemogenic and genotoxic. DU possesses both a radiological (alpha particle) and chemical (metal) component but is generally considered a chemical biohazard. Studies have shown that alpha particle radiation does play a role in DU's toxic effects...
September 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28530149/a-technology-roadmap-of-smart-biosensors-from-conventional-glucose-monitoring-systems
#19
Pravin Shende, Pratiksha Sahu, Ram Gaud
The objective of this review article is to focus on technology roadmap of smart biosensors from a conventional glucose monitoring system. The estimation of glucose with commercially available devices involves analysis of blood samples that are obtained by pricking finger or extracting blood from the forearm. Since pain and discomfort are associated with invasive methods, the non-invasive measurement techniques have been investigated. The non-invasive methods show advantages like non-exposure to sharp objects such as needles and syringes, due to which there is an increase in testing frequency, improved control of glucose concentration and absence of pain and biohazard materials...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28490143/method-for-sampling-and-analysis-of-volatile-biomarkers-in-process-gas-from-aerobic-digestion-of-poultry-carcasses-using-time-weighted-average-spme-and-gc-ms
#20
Jacek A Koziel, Lam T Nguyen, Thomas D Glanville, Heekwon Ahn, Timothy S Frana, J Hans van Leeuwen
A passive sampling method, using retracted solid-phase microextraction (SPME) - gas chromatography-mass spectrometry and time-weighted averaging, was developed and validated for tracking marker volatile organic compounds (VOCs) emitted during aerobic digestion of biohazardous animal tissue. The retracted SPME configuration protects the fragile fiber from buffeting by the process gas stream, and it requires less equipment and is potentially more biosecure than conventional active sampling methods. VOC concentrations predicted via a model based on Fick's first law of diffusion were within 6...
October 1, 2017: Food Chemistry
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