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https://www.readbyqxmd.com/read/27916937/the-emergence-and-epidemiology-of-haff-disease-in-china
#1
REVIEW
Thomas Y K Chan
Haff disease is a rare syndrome of unexplained myalgia and rhabdomyolysis occurring within 24 h of consumption of certain types of cooked freshwater fish or crustacean. It is caused by a yet unidentified heat-stable toxin. In the present review of published case studies and official press releases, the main objective is to report the emergence and epidemiology of Haff disease in China. Haff disease first occurred in Beijing in 2000 and in Lianzhou and Liannan, Guangdong Province in 2009. Subsequent outbreaks mostly occurred in the Jiangsu Province-Nanjing, Yangzhou, Huai'an, and Yancheng...
December 1, 2016: Toxins
https://www.readbyqxmd.com/read/27859996/microphthalmia-associated-transcription-factor-ensures-the-elongation-of-axons-and-dendrites-in-the-mouse-frontal-cortex
#2
Koji Ohba, Kazuhisa Takeda, Tamio Furuse, Tomohiro Suzuki, Shigeharu Wakana, Takashi Suzuki, Hiroaki Yamamoto, Shigeki Shibahara
Long interspersed element-1 (LINE-1) is a mammalian transposable element, and its genomic insertion could cause neurological disorders in humans. Incidentally, LINE-1 is present in intron 3 of the microphthalmia-associated transcription factor (Mitf) gene of the black-eyed white mouse (Mitf(mi-bw) allele). Mice homozygous for the Mitf(mi-bw) allele show the white coat color with black eye and deafness. Here, we explored the functional consequences of the LINE-1 insertion in the Mitf gene using homozygous Mitf(mi-bw) mice on the C3H background (C3H-bw mice) or on the C57BL/6 background (bw mice)...
November 11, 2016: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/27806120/comparison-of-the-efficacies-and-safety-of-combined-therapy-between-telbivudine-plus-adefovir-and-lamivudine-plus-adefovir-in-patients-with-hepatitis-b-virus-infection-in-real-world-practice
#3
Ming-Tsung Lin, Yi-Hao Yen, Ming-Chao Tsai, Po-Lin Tseng, Kuo-Chin Chang, Cheng-Kun Wu, Tsung-Hui Hu
BACKGROUND AND AIM: Chronic hepatitis B infection remains a significant health issue worldwide. This study evaluated the efficacy and safety of combined therapy using lamivudine plus adefovir (LAM+ADV) versus telbivudine plus adefovir (LdT+ADV) and the corresponding renal function change and safety. METHODS: This study enrolled a total of 171 patients (110 patients received LAM+ADV and 60 patients received LdT+ADV). We analyzed the changes in renal function using the estimated glomerular filtration rate (eGFR)...
2016: PloS One
https://www.readbyqxmd.com/read/27717598/-statin-associated-myopathy-in-clinical-practice-results-of-dama-study
#4
Jesús Millán, Juan Pedro-Botet, Elisenda Climent, Joaquín Millán, Joan Rius
BACKGROUND AND OBJECTIVE: Muscle symptoms, with or without elevation of creatin kinase are one of the main adverse effects of statin therapy, a fact that sometimes limits their use. The aim of this study was to evaluate the clinical characteristics of patients treated with statins who have complained muscle symptoms and to identify possible predictive factors. PATIENTS AND METHODS: A cross-sectional one-visit, non-interventional, national multicenter study including patients of both sexes over 18 years of age referred for past or present muscle symptoms associated with statin therapy was conducted...
October 4, 2016: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/27611058/a-validated-lc-ms-ms-method-for-the-quantitative-measurement-of-creatinine-as-an-endogenous-biomarker-in-human-plasma
#5
Yue Zhao, Guowen Liu, Aida Angeles, Lisa J Christopher, Zhaoqing Wang, Mark E Arnold, Jim X Shen
BACKGROUND: Creatinine is an endogenous compound generated from creatine by normal muscular metabolism. It is an important indicator of renal function and the serum level is routinely monitored in clinical labs. Results & methodology: Surrogate analyte (d3-creatinine) was used for calibration standard and quality control preparation and the relative instrument response ratio between creatinine and d3-creatinine was used to calculate the endogenous creatinine concentrations. CONCLUSION: A fit-for-purpose strategy of using a surrogate analyte and authentic matrix was adopted for this validation...
October 2016: Bioanalysis
https://www.readbyqxmd.com/read/27592805/avelumab-in-patients-with-chemotherapy-refractory-metastatic-merkel-cell-carcinoma-a-multicentre-single-group-open-label-phase-2-trial
#6
Howard L Kaufman, Jeffery Russell, Omid Hamid, Shailender Bhatia, Patrick Terheyden, Sandra P D'Angelo, Kent C Shih, Céleste Lebbé, Gerald P Linette, Michele Milella, Isaac Brownell, Karl D Lewis, Jochen H Lorch, Kevin Chin, Lisa Mahnke, Anja von Heydebreck, Jean-Marie Cuillerot, Paul Nghiem
BACKGROUND: Merkel cell carcinoma is a rare, aggressive skin cancer with poor prognosis in patients with advanced disease. Current standard care uses various cytotoxic chemotherapy regimens, but responses are seldom durable. Tumour oncogenesis is linked to Merkel cell polyomavirus integration and ultraviolet-radiation-induced mutations, providing rationale for treatment with immunotherapy antibodies that target the PD-L1/PD-1 pathway. We assessed treatment with avelumab, an anti-PD-L1 monoclonal antibody, in patients with stage IV Merkel cell carcinoma that had progressed after cytotoxic chemotherapy...
October 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27518853/nmr-based-metabonomic-analysis-of-physiological-responses-to-starvation-and-refeeding-in-the-rat
#7
José I Serrano-Contreras, Isabel García-Pérez, María E Meléndez-Camargo, L Gerardo Zepeda
Starvation is a postabsorptive condition derived from a limitation on food resources by external factors. Energy homeostasis is maintained under this condition by using sources other than glucose via adaptive mechanisms. After refeeding, when food is available, other adaptive processes are linked to energy balance. However, less has been reported about the physiological mechanisms present as a result of these conditions, considering the rat as a supraorganism. Metabolic profiling using (1)H nuclear magnetic resonance spectroscopy was used to characterize the physiological metabolic differences in urine specimens collected under starved, refed, and recovered conditions...
September 2, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27508716/-op-1a-05-nocturnal-blood-pressure-relates-more-closely-to-kidney-disease-in-the-dublin-outcome-study
#8
E Dolan, E O'Brien
OBJECTIVE: Hypertension is the most common modifiable risk factor for cardiovascular disease. It is also the fastest growing reason for renal replacement therapy. Ambulatory blood pressure (ABP) has consistently been shown to be a superior predictor of cardiovascular risk to that measured in the clinic setting. There is however limited data in its use to risk stratify patients with renal dysfunction We studied the relationship between ABP and renal disease in a in a cohort of non-diabetic hypertensive patients...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27500131/acute-rhabdomyolysis-following-synthetic-cannabinoid-ingestion
#9
Demilade A Adedinsewo, Oluwaseun Odewole, Taylor Todd
CONTEXT: Novel psychoactive substances, including synthetic cannabinoids, are becoming increasingly popular, with more patients being seen in the emergency room following acute ingestion. These substances have been associated with a wide range of adverse effects. However, identification of complications, clinical toxicity, and management remain challenging. CASE REPORT: We present the case of a young African-American male who developed severe agitation and bizarre behavior following acute K2 ingestion...
June 2016: North American Journal of Medical Sciences
https://www.readbyqxmd.com/read/27469384/ciprofloxacin-and-statin-interaction-a-cautionary-tale-of-rhabdomyolysis
#10
Fraser Charles Goldie, Amy Brogan, James Graham Boyle
A 62-year-old woman presented to hospital, on general practitioner (GP) advice, with a 15-day history of slowly progressing muscle weakness. Results showed newly deranged liver function and creatine kinase (CK) of >24 000. Prior medical history includes previous myocardial infarction and recurrent urinary tract infection. 4 days prior to symptom onset, the patient developed typical urinary tract infection symptoms, treated with ciprofloxacin. The patient had been taking simvastatin (40 mg nocte) for 13 years and had never previously taken ciprofloxacin...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27466783/conjugated-linoleic-acid-rat-pretreatment-reduces-renal-damage-in-ischemia-reperfusion-injury-unraveling-antiapoptotic-mechanisms-and-regulation-of-phosphorylated-mammalian-target-of-rapamycin-p-mtor
#11
Gholamali Javedan, Farzad Shidfar, Sayed Hossein Davoodi, Marjan Ajami, Fazel Gorjipour, Antoni Sureda, Seyed Mohammad Nabavi, Maria Daglia, Hamidreza Pazoki Toroudi
SCOPE: Conjugated linoleic acids (CLAs) are dietary components with beneficial effects on human health. The aim of this study was to evaluate the potential benefits of CLA pretreatment in a rat model of renal ischemia/reperfusion injury (IRI). METHODS AND RESULTS: Animals were treated with CLAs (200mg/kg/day) or water for two weeks prior to sham surgery or to surgery to induce IRI. Renal function, oxidative stress, apoptosis, and cell proliferation markers, were evaluated...
July 28, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27398683/joint-influence-of-protein-supplements-soft-drinks-and-extreme-physical-activity-on-the-development-of-acute-renal-failure-and-hypokalaemia
#12
S Djordjevic, D Kitic, M Kostic, B Apostolovic, S Brankovic, I M Ciric, R Velickovic-Radovanovic
We present a case of a 33-year old man who complained of weakness, fever and decreased urinating. A personal history revealed a consumption of creatine, protein supplements, soft drinks containing caffeine and stevia, and extreme physical activity which included lifting of heavy weights. The patient developed anuria, uraemia, fatigue, rhabdomyolysis and paradoxical hypokalaemia. After the patient had seven successive dialysis treatments, normal kidney function was restored. The report presents the first case of acute renal failure followed by hypokalaemia due to the combined action of the excessive consumption of supplements, soft drinks with stevia and caffeine, and extreme physical activity...
November 13, 2015: West Indian Medical Journal
https://www.readbyqxmd.com/read/27194210/comparative-b-mode-and-doppler-renal-ultrasonography-with-histopathological-findings-in-dogs-positive-for-canine-visceral-leishmaniasis
#13
Pollyana Irene Baltazar, Laecio Da Silva Moura, Gerson Tavares Pessoa, Renan Paraguassu De Sá Rodrigues, Marina Pinto Sanches, Anaemilia Das Neves Diniz, Francisco Das Chagas Araújo Sousa, Porfírio Candanedo Guerra, Willams Costa Neves, Robson Fortes Giglio, Jacyara De Jesus Rosa Pereira Alves, Francisco De Assis Leite Souza, Juliana Fortes Vilarinho Braga, Flávio Ribeiro Alves
Morphological parameters and renal flow were assessed and measured in six clinically healthy dogs with negative serological and parasitological examinations for canine visceral leishmaniasis (CVL) and six dogs with CVL-positive serological and parasitological tests and asymptomatic condition of the disease. Kidney length and diameter were measured and compared with the aorta/kidney ratio. Alterations in flow were measured using the flow velocity (cm/s) and resistance index (RI). Renal function was assessed by serum biochemical examination (urea, creatine, total proteins, albumin, and globulin) and urinalysis...
July 2016: Microscopy Research and Technique
https://www.readbyqxmd.com/read/27186145/changes-in-blood-biochemical-markers-before-during-and-after-a-2-day-ultramarathon
#14
Kazuyuki Arakawa, Akihiro Hosono, Kiyoshi Shibata, Reza Ghadimi, Mizuho Fuku, Chiho Goto, Nahomi Imaeda, Yuko Tokudome, Hideki Hoshino, Mitsuhiro Marumoto, Masaaki Kobayashi, Sadao Suzuki, Shinkan Tokudome
We studied changes in blood markers of 18 nonprofessional, middle-aged runners of a 2-day, 130 km ultramarathon. Blood was sampled at baseline, after the goals on the first and second day, and at three time points (1, 3, and 5/6 days) after the race. Blood indices showed three patterns. First pattern indices showed essentially no changes after the two goals and after the race, including red blood cell indices, gamma-glutamyl transferase, and tumor necrosis factor-α. Second pattern markers, including the majority of indices, were elevated during the race (and also after the race for some parameters) and then returned to baseline afterward, including hemolysis/red blood cell destruction markers (indirect bilirubin) and an iron reservoir index (ferritin), muscle damage parameters (uric acid, creatine kinase, lactate dehydrogenase, and aspartate aminotransferase), renal function markers (creatinine and blood urea nitrogen), liver injury index (alanine aminotransferase), lipid metabolism indices (free fatty acid), reactive oxygen species and inflammation parameters (white blood cells, interleukin-6, and C-reactive protein), and energy production and catecholamines (adrenaline, noradrenaline, and dopamine)...
2016: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/27180201/calcitriol-decreases-pro-inflammatory-cytokines-and-protects-against-severe-hemorrhagic-shock-induced-organ-damage-in-rats
#15
Jen-Pi Tsai, Chung-Jen Lee, Yi-Maun Subeq, Ru-Ping Lee, Bang-Gee Hsu
INTRODUCTION: Resuscitation after hemorrhagic shock (HS) could result in increased pro-inflammatory cytokines and then multiple organ dysfunctions. Calcitriol exerts pleiotropic effects in a wide variety of target tissues and has a role against anti-inflammation. The present study was aimed to investigate the modulatory effects of calcitriol on the pathophysiological and inflammatory markers following HS in rats. MATERIALS AND METHODS: By withdrawing 60% of the total blood volume over 30min via a femoral artery catheter in rats, HS was induced...
July 2016: Cytokine
https://www.readbyqxmd.com/read/27093966/postoperative-elevation-in-creatine-kinase-and-its-impact-on-renal-function-in-patients-undergoing-complex-partial-nephrectomy
#16
Abhinav Sidana, Annerleim Walton-Diaz, Hong Truong, M Minhaj Siddiqui, Ning Miao, Johanna Shih, Andrew Mannes, Gennady Bratslavsky, W Marston Linehan, Adam R Metwalli
OBJECTIVE: To identify the risk factors associated with development of postoperative elevation of creatine kinase (CK) and study its effect on renal function in patients who underwent complex multifocal partial nephrectomy (PN). METHODS: Patients who underwent PN at National Cancer Institute between January 2007 and December 2012 were included in the study. Elevated serum CK was defined as >2000 U/L. Kidney function was assessed using serum creatinine and estimated glomerular filtration rate (eGFR)...
July 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27062777/-continuous-veno-venous-hemofiltration-in-goat-model-with-crush-syndrome
#17
Yi Tang, Ling Zhang, Ying-ying Yang, Yu-liang Zhao, Ping Fu
OBJECTIVE: Crush syndrome (CS) is a common critical condition. This study aimed to establish crush syndrome goat model through muscle injection of glycerol and test the effect of continuous veno-venous hemofiltraion (CVVH). METHODS: 12 male goats at 12-15 months age were randomly assigned into control, model, and CVVH groups. After 2 weeks of normal feeding, the goats were weighed and stripped off foods for 24 h. Goats in the model and CVVH groups were then injected with 50% glycerol athind legs...
January 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/27055155/abatacept-treatment-does-not-preserve-renal-function-in-the-streptozocin-induced-model-of-diabetic-nephropathy
#18
Jenny Norlin, Lisbeth Nielsen Fink, Peter Helding Kvist, Elisabeth Douglas Galsgaard, Ken Coppieters
Diabetic nephropathy (DN) is one of the most severe complications of diabetes and remains the largest cause of end-stage renal disease in the Western world. Treatment options are limited and novel therapies that effectively slow disease progression are warranted. Previous work suggested that treatment with CTLA4-Ig (abatacept), a molecule that binds and blocks B7-1 and is licensed for the treatment of rheumatoid arthritis, could ameliorate DN. This study was designed to assess whether B7-1 signalling constitutes a promising therapeutic pathway for DN...
2016: PloS One
https://www.readbyqxmd.com/read/27034948/rhabdomyolysis-following-cardiac-surgery-a-prospective-descriptive-single-center-study
#19
Amr S Omar, Hesham Ewila, Sameh Aboulnaga, Alejandro Kohn Tuli, Rajvir Singh
PURPOSE: Rhabdomyolysis (RML) following cardiac surgery and its relationship with acute kidney injury (AKI) require investigation. PATIENTS AND METHODS: All patients undergoing cardiac surgery in our hospital were enrolled in this prospective study during a 1-year period. To investigate the occurrence of RML and its association with AKI, all patients in the study underwent serial assessment of serum creatine kinase (CK) and myoglobin levels. Serial renal function, prior statin treatment, and outcome variables were recorded...
2016: BioMed Research International
https://www.readbyqxmd.com/read/26932211/-correlation-between-cognitive-impairment-and-diabetic-nephropathy-in-patients-with-type-2-diabetes-mellitus
#20
Xiajie Shi, Yuren Zhang, Hongtao Niu, Ran Wang, Jinjing Shen, Shanlei Zhou, Haobo Yang, Shan Wang, Jing Wu
OBJECTIVE: To explore the correlation between diabetic nephropathy (DN) and cognitive impairment through examining the cognitive function and the metabolism of the cerebrum in Type 2 diabetes mellitus patients at different stages of renal function.
 METHODS: Eighty six patients with Type 2 diabetes mellitus (T2DM) were enrolled for this study. According to the urinary albumin excretion rate (UAER), the patients were divided into a T2DM without DN group (DM group, n=33), an early DN group (DN-III group, n=26) and a clinical stage group (DN-IV group, n=27)...
February 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
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