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https://www.readbyqxmd.com/read/28092013/sharpening-the-cutting-edge-additional-considerations-for-the-uk-debates-on-embryonic-interventions-for-mitochondrial-diseases
#1
Erica Haimes, Ken Taylor
In October 2015 the UK enacted legislation to permit the clinical use of two cutting edge germline-altering, IVF-based embryonic techniques: pronuclear transfer and maternal spindle transfer (PNT and MST). The aim is to use these techniques to prevent the maternal transmission of serious mitochondrial diseases. Major claims have been made about the quality of the debates that preceded this legislation and the significance of those debates for UK decision-making on other biotechnologies, as well as for other countries considering similar legislation...
December 2017: Life Sciences, Society and Policy
https://www.readbyqxmd.com/read/28090758/bringing-clarity-or-confusion-the-role-of-prostate-specific-membrane-antigen-positron-emission-computed-tomography-for-primary-staging-in-prostate-cancer
#2
EDITORIAL
Declan G Murphy, Michael Hofman, Nathan Lawrentschuk, Tobias Maurer
No abstract text is available yet for this article.
February 2017: BJU International
https://www.readbyqxmd.com/read/28090700/the-mandarin-chinese-version-of-the-beach-centre-family-quality-of-life-scale-development-and-psychometric-properties-in-taiwanese-families-of-children-with-developmental-delay
#3
S-J Chiu, P-T Chen, Y-T Chou, L-Y Chien
BACKGROUND: Early intervention (EI) practitioners provide individualised family-centred services to enhance the quality of life (QOL) of families of children with developmental delay (DD). Family QOL (FQOL) could be an important outcome indictor for EI, but there is no measurement tool for FQOL in Mandarin Chinese. The purpose of this study was to translate the Beach Centre FQOL Scale (BCFQOL) into Mandarin Chinese and to examine the psychometric properties of the scale in families of children with DD...
January 16, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28090587/emotional-clarity-as-a-buffer-in-the-association-between-perceived-mental-illness-stigma-and-suicide-risk
#4
Katie Wang, Nicole H Weiss, John E Pachankis, Bruce G Link
Among people living with psychiatric disorders, mental illness stigma has been identified as a major barrier to recovery by contributing to low self-esteem and interfering with treatment-seeking. The present research examined the association between perceived mental illness stigma and suicide risk severity and considered the role of emotional clarity (i.e., the ability to identify and understand one's emotional experiences), a critical component of emotion regulation, as a moderator of this association. A sample of individuals who had experienced recent psychiatric hospitalizations (N = 184) completed self-report measures of perceived stigma associated with their psychiatric diagnoses, deficits in emotional clarity, and behaviors that have been found to confer risk for suicide...
November 2016: Stigma and Health
https://www.readbyqxmd.com/read/28090286/novel-methods-in-pulmonary-hypertension-phenotyping-in-the-age-of-precision-medicine-2015-grover-conference-series
#5
REVIEW
Jarrod W Barnes, Adriano R Tonelli, Gustavo A Heresi, Jennie E Newman, Noël E Mellor, David E Grove, Raed A Dweik
Among pulmonary vascular diseases, pulmonary hypertension (PH) is the best studied and has been the focus of our work. The current classification of PH is based on a relatively simple combination of patient characteristics and hemodynamics. This leads to inherent limitations, including the inability to customize treatment and the lack of clarity from a more granular identification based on individual patient phenotypes. Accurate phenotyping of PH can be used in the clinic to select therapies and determine prognosis and in research to increase the homogeneity of study cohorts...
December 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/28090095/academic-freedom-should-be-redefined-point-and-counterpoint
#6
Tonja M Woods, W Renee' Acosta, Eunice P Chung, Arthur G Cox, George A Garcia, Jamie Ridley Klucken, Marie Chisholm-Burns
As part of the 2014-15 Academic Leadership Fellows Program, the cohort teams presented debates on topics relevant to academic pharmacy at a public forum during the 2015 American Association of Colleges of Pharmacy Interim Meeting. The topic of one of the debates was "Academic Freedom Should Be Redefined." The "point" of the debate focused on important issues such as the fundamental definition of academic freedom as it was written in the 1940 American Association of University Professors' Statement and the need for redefinition as a consequence of many misunderstandings and misinterpretations that have arisen over time...
November 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28089278/estimating-uptake-of-phthalate-ester-metabolites-into-the-human-nail-plate-using-pharmacokinetic-modelling
#7
Thuy T Bui, Andreia Alves, Anna Palm-Cousins, Stefan Voorspoels, Adrian Covaci, Ian T Cousins
There is a lack of knowledge regarding uptake of phthalate esters (PEs) and other chemicals into the human nail plate and thus, clarity concerning the suitability of human nails as a valid alternative matrix for monitoring long-term exposure. In particular, the relative importance of internal uptake of phthalate metabolites (from e.g. blood) compared to external uptake pathways is unknown. This study provides first insights into the partitioning of phthalate-metabolites between blood and nail using pharmacokinetic (PK) modelling and biomonitoring data from a Norwegian cohort...
January 11, 2017: Environment International
https://www.readbyqxmd.com/read/28087163/clinical-studies-of-ex-vivo-expansion-to-accelerate-engraftment-after-umbilical-cord-blood-transplantation-a-systematic-review
#8
REVIEW
Jeffrey Kiernan, Pauline Damien, Madeline Monaghan, Risa Shorr, Lauralyn McIntyre, Dean Fergusson, Alan Tinmouth, David Allan
Cell dose limits greater use of umbilical cord blood (UCB) in hematopoietic cell transplantation. The clinical benefits of ex vivo expansion need clarity to understand its potential impact. A systematic search of studies addressing UCB ex vivo expansion was conducted. Fifteen clinical studies (349 transplanted patients) and 13 registered trials were identified. The co-infusion of an expanded unit and a second unmanipulated unit (8 studies), the fractional expansion of 12% to 60% of a single unit (5 studies), and the infusion of a single expanded unit (2 studies) were reported...
December 23, 2016: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28073337/microaggressions
#9
Scott O Lilienfeld
The microaggression concept has recently galvanized public discussion and spread to numerous college campuses and businesses. I argue that the microaggression research program (MRP) rests on five core premises, namely, that microaggressions (1) are operationalized with sufficient clarity and consensus to afford rigorous scientific investigation; (2) are interpreted negatively by most or all minority group members; (3) reflect implicitly prejudicial and implicitly aggressive motives; (4) can be validly assessed using only respondents' subjective reports; and (5) exert an adverse impact on recipients' mental health...
January 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28071678/multiple-myeloma-in-2016-fresh-perspectives-on-treatment-and-moments-of-clarity
#10
Prashant Kapoor, S Vincent Rajkumar
No abstract text is available yet for this article.
January 10, 2017: Nature Reviews. Clinical Oncology
https://www.readbyqxmd.com/read/28070225/how-does-genetic-risk-information-for-lynch-syndrome-translate-to-risk-management-behaviours
#11
Emma Steel, Andrew Robbins, Mark Jenkins, Louisa Flander, Clara Gaff, Louise Keogh
BACKGROUND: There is limited research on why some individuals who have undergone predictive genetic testing for Lynch syndrome do not adhere to screening recommendations. This study aimed to explore qualitatively how Lynch syndrome non-carriers and carriers translate genetic risk information and advice to decisions about risk managment behaviours in the Australian healthcare system. METHODS: Participants of the Australasian Colorectal Cancer Family Registry who had undergone predictive genetic testing for Lynch syndrome were interviewed on their risk management behaviours...
2017: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/28068875/online-counseling-an-exploratory-survey-of-italian-psychologists-attitudes-towards-new-ways-of-interaction
#12
Sabrina Cipolletta, Damiano Mocellin
OBJECTIVE: Online counseling may be defined as an interaction between users and mental health professionals that takes place through computer mediated communication technology. This study aimed to investigate the attitudes of Italian psychologists towards different aspects of online counseling provided via email, chat, forums, and videoconference. METHOD: An online questionnaire was administered to a sample of 289 licensed psychologists in the Veneto Region (Italy) in order to collect opinions, preferences, and intentions to use online modalities, along with prior knowledge and practice experiences...
January 9, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/28068052/revision-of-import-and-export-requirements-for-controlled-substances-listed-chemicals-and-tableting-and-encapsulating-machines-including-changes-to-implement-the-international-trade-data-system-itds-revision-of-reporting-requirements-for-domestic-transactions
#13
(no author information available yet)
The Drug Enforcement Administration is updating its regulations for the import and export of tableting and encapsulating machines, controlled substances, and listed chemicals, and its regulations relating to reports required for domestic transactions in listed chemicals, gamma-hydroxybutyric acid, and tableting and encapsulating machines. In accordance with Executive Order 13563, the Drug Enforcement Administration has reviewed its import and export regulations and reporting requirements for domestic transactions in listed chemicals (and gamma-hydroxybutyric acid) and tableting and encapsulating machines, and evaluated them for clarity, consistency, continued accuracy, and effectiveness...
30, 2016: Federal Register
https://www.readbyqxmd.com/read/28067805/content-validation-and-semantic-evaluation-of-a-check-list-elaborated-for-the-prevention-of-gluten-cross-contamination-in-food-services
#14
Priscila Farage, Renata Puppin Zandonadi, Verônica Cortez Ginani, Lenora Gandolfi, Riccardo Pratesi, Yanna Karla de Medeiros Nóbrega
Conditions associated to the consumption of gluten have emerged as a major health care concern and the treatment consists on a lifelong gluten-free diet. Providing safe food for these individuals includes adapting to safety procedures within the food chain and preventing gluten cross-contamination in gluten-free food. However, a gluten cross-contamination prevention protocol or check-list has not yet been validated. Therefore, the aim of this study was to perform the content validation and semantic evaluation of a check-list elaborated for the prevention of gluten cross-contamination in food services...
January 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28067677/the-microbiome-in-mechanically-ventilated-patients
#15
Yudong Yin, Peter Hountras, Richard G Wunderink
PURPOSE OF REVIEW: Discovery of a normal lung microbiome requires reassessment of our concepts of HAP/VAP pathogenesis and has important implications for clinical diagnosis and management. RECENT FINDINGS: Changes in the microbiome of dental plaque are associated with increased risk of HAP/VAP. A transition to a lung microbiome enriched with gut flora is found in ARDS with an increased inflammatory response in patients with this change in microbial flora. A characteristic microbiome pattern of higher amounts of bacterial DNA, lower community diversity, and greater relative abundance of a single species characterize pneumonia and occasionally identify bacteria not found in culture...
January 6, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28067508/coherent-brightfield-microscopy-provides-the-spatiotemporal-resolution-to-study-early-stage-viral-infection-in-live-cells
#16
Yi-Fan Huang, Guan-Yu Zhuo, Chun-Yu Chou, Cheng-Hao Lin, Wen Chang, Chia-Lung Hsieh
Viral infection starts with a virus particle landing on a cell surface followed by penetration of the plasma membrane. Due to the difficulty of measuring the rapid motion of small-sized virus particles on the membrane, little is known about how a virus particle reaches an endocytic site after landing at a random location. Here, we use coherent brightfield (COBRI) microscopy to investigate early stage viral infection with ultrahigh spatiotemporal resolution. By detecting intrinsic scattered light via imaging-based interferometry, COBRI microscopy allows us to track the motion of a single vaccinia virus particle with nanometer spatial precision (<3 nm) in 3D and microsecond temporal resolution (up to 100,000 frames per second)...
January 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28067033/2016-updated-american-society-of-clinical-oncology-oncology-nursing-society-chemotherapy-administration-safety-standards-including-standards-for-pediatric-oncology
#17
Michael Neuss, Terry Gilmore, Kristin Belderson, Amy Billett, Tara Conti-Kalchik, Brittany Harvet, Carolyn Hendricks, Kristine LeFebvre, Pamela Mangu, Kristen McNiff, MiKaela Olsen, Lisa Schulmeister, Anne Von Gehr, Martha Polovich
Purpose: To update the American Society of Clinical Oncology (ASCO)/Oncology Nursing Society (ONS) Chemotherapy Administration Safety Standards and to highlight standards for pediatric oncology. Methods: The ASCO/ONS Chemotherapy Administration Safety Standards were first published in 2009 and updated in 2011 to include inpatient settings. A subsequent 2013 revision expanded the standards to include the safe administration and management of oral chemotherapy. A joint ASCO/ONS workshop with stakeholder participation, including that of the Association of Pediatric Hematology Oncology Nurses and American Society of Pediatric Hematology/Oncology, was held on May 12, 2015, to review the 2013 standards...
6, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28066693/society-of-pediatric-psychology-workforce-survey-development-of-survey-methods-sample-characteristics-and-lessons-learned
#18
Tim Wysocki, Cheryl L Brosig, Marisa E Hilliard
There are few detailed workforce studies of specialty fields within professional psychology, and none have been reported for pediatric psychology since 2006. Availability of such data could facilitate more-informed decision making by students and trainees, psychologists pursuing employment opportunities, and psychologists involved in employment or compensation negotiations. This article describes the work of a task force of the American Psychological Association (APA) Division 54 (Society of Pediatric Psychology) in the design, construction, pretesting, distribution, and data management for the Society of Pediatric Psychology (SPP) Workforce Survey...
March 2016: Clinical Practice in Pediatric Psychology
https://www.readbyqxmd.com/read/28064289/views-of-faculty-members-in-a-medical-school-with-regards-to-error-disclosure-and-reporting-to-parents-and-or-higher-authorities
#19
C H Wong, A C L Phuah, N S Y Naik, W S Choo, H S Y Ting, S M L Kuan, C L Teng, N Sivalingam
BACKGROUND: Little is known about the views of faculty members who train medical students concerning open disclosure. OBJECTIVES: The objectives of this study were to determine the views of faculty in a medical school on: 1 what constitutes a medical error and the severity of such an error in relation to medication use or diagnosis; 2 information giving following such an adverse event, based on severity; and 3 acknowledgement of responsibility, remedial action, compensation, disciplinary action, legal action, and reporting to a higher body in relation to such adverse event...
October 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28063772/white-matter-hyperintensity-associations-with-cerebral-blood-flow-in-elderly-subjects-stratified-by-cerebrovascular-risk
#20
Ahmed A Bahrani, David K Powell, Guoquiang Yu, Eleanor S Johnson, Gregory A Jicha, Charles D Smith
OBJECTIVE: This study aims to add clarity to the relationship between deep and periventricular brain white matter hyperintensities (WMHs), cerebral blood flow (CBF), and cerebrovascular risk in older persons. METHODS: Deep white matter hyperintensity (dWMH) and periventricular white matter hyperintensity (pWMH) and regional gray matter (GM) and white matter (WM) blood flow from arterial spin labeling were quantified from magnetic resonance imaging scans of 26 cognitively normal elderly subjects stratified by cerebrovascular disease (CVD) risk...
January 4, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
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