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https://www.readbyqxmd.com/read/29240797/a-mucoadhesive-thermoreversible-in-situ-nasal-gel-of-geniposide-for-neurodegenerative-diseases
#1
Yingting Wang, Shulong Jiang, Hongli Wang, Haiyan Bie
Neurodegenerative diseases are becoming prevalent as the population ages. Geniposide could inhibit oxidative stress, reduce apoptosis, protect neuron, and has been used for therapy of the neurodegenerative diseases. The bioavailability of geniposide by nasal route is greater than that by oral administration. However, mucociliary clearance is a rate-limiting factor for nasal route administration. The objective of this study was to develop and evaluate a mucoadhesive, thermoreversible in situ nasal gel of geniposide...
2017: PloS One
https://www.readbyqxmd.com/read/29240658/nursing-activities-for-patients-with-chronic-disease-in-primary-care-settings-a-practice-analysis
#2
Marie-Eve Poitras, Maud-Christine Chouinard, Frances Gallagher, Martin Fortin
BACKGROUND: Nurses in primary care organizations play a central role for patients with chronic disease. Lack of clarity in role description may be associated with underutilization of nurse competencies that could benefit the growing population of patients with chronic disease. OBJECTIVE: The purpose of the research was to describe nursing activities in primary care settings with patients with chronic disease. METHODS: A Web-based survey was sent to nurses practicing in Family Medicine Groups in the Canadian Province of Québec...
January 2018: Nursing Research
https://www.readbyqxmd.com/read/29239921/inferiorly-pedicled-nasolabial-flap-for-reconstruction-of-anterior-maxilla-defects-class-i-and-ii
#3
Qingli Chen, Keremu Abasi, Zhongcheng Gong, Bin Ling, Hui Liu, Bo Shao
OBJECTIVES: The aim of this study was to present the use of inferiorly pedicled nasolabial flap (IPNF) in the reconstruction of anterior maxilla defects class I and II. METHODS: Seven patients, 4 females and 3 males, aging from 38 to 75 (mean = 55.9) years old, from 2014 to 2017 reconstructed anterior part of maxilla with or without oronasal communication were included in this study. Five patients diagnosed with squamous cell carcinoma, 1 patient presented with epithelial-myoepithelial carcinoma, and 1 patient had ameloblastoma...
December 12, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29237718/use-of-pro-measures-to-inform-tolerability-in-oncology-trials-implications-for-clinical-review-ind-safety-reporting-and-clinical-site-inspections
#4
Janice Kim, Harpreet Singh, Kassa Ayalew, Kristina Borror, Michelle Campbell, Laura Lee Johnson, Alyson Karesh, Ni A Khin, Joanne R Less, Jerry Menikoff, Lori Minasian, Sandra A Mitchell, Elektra J Papadopoulos, Richard L Piekarz, Kevin A Prohaska, Susan Thompson, Rajeshwari Sridhara, Richard Pazdur, Paul G Kluetz
Cancer therapeutics frequently lead to symptomatic adverse events (AEs) that can affect treatment tolerability. The National Cancer Institute has developed a patient-reported outcome (PRO) version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) to assess symptomatic AEs by direct patient self-report. While longitudinal assessment of patient-reported symptomatic AEs holds promise to better inform treatment tolerability, using PRO measures to assess symptomatic AEs has raised several regulatory and good clinical practice (GCP) issues among those who conduct cancer clinical trials...
December 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29236929/towards-a-standard-protocol-for-antimony-intralesional-infiltration-technique-for-cutaneous-leishmaniasis-treatment
#5
Rosiana Estéfane da Silva, Janaína de Pina Carvalho, Dario Brock Ramalho, Maria Camilo Ribeiro De Senna, Hugo Silva Assis Moreira, Ana Rabello, Erika Cota, Gláucia Cota
BACKGROUND Despite its recognised toxicity, antimonial therapy continues to be the first-line drug for cutaneous leishmaniasis (CL) treatment. Intralesional administration of meglumine antimoniate (MA) represents an alternative that could reduce the systemic absorption of the drug and its side effects. OBJECTIVES This study aims to validate the standard operational procedure (SOP) for the intralesional infiltration of MA for CL therapy as the first step before the assessment of efficacy and safety related to the procedure...
February 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29236837/construction-and-validation-of-a-nursing-care-protocol-in-anesthesia
#6
Cassiane de Santana Lemos, Vanessa de Brito Poveda, Aparecida de Cassia Giane Peniche
OBJECTIVE: To construct and validate a nursing care protocol in anesthesia. METHOD: methodological study of face and content validation, judging clarity, relevance, pertinence and comprehensiveness of a care protocol, elaborated from the integrative review of previous literature and based on the conceptual model of assistance perioperative nursing of Castellanos and Jouclas. The protocol was evaluated by five anesthesiologists and nurses from the surgical center...
December 11, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29236560/examining-the-nature-of-interprofessional-practice-an-initial-framework-validation-and-creation-of-the-interprofessional-activity-classification-tool-interpact
#7
Andreas Xyrichis, Scott Reeves, Merrick Zwarenstein
The practice of, and research on interprofessional working in healthcare, commonly referred to as teamwork, has been growing rapidly. This has attracted international policy support flowing from the growing belief that patient safety and quality of care can only be achieved through the collective effort of the multiple professionals caring for a given patient. Despite the increasing policy support, the evidence for effectiveness lags behind: while there are supporting analytic epidemiological studies, few reliable intervention studies have been published and so we have yet to confirm a causal link...
December 13, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/29236552/website-designs-for-communicating-about-chemicals-in-cigarette-smoke
#8
Allison J Lazard, M Justin Byron, Huyen Vu, Ellen Peters, Annie Schmidt, Noel T Brewer
The Family Smoking Prevention and Tobacco Control Act requires the US government to inform the public about the quantities of toxic chemicals in cigarette smoke. A website can accomplish this task efficiently, but the site's user interface must be usable to benefit the general public. We conducted online experiments with national convenience samples of 1,451 US adult smokers and nonsmokers to examine the impact of four interface display elements: the chemicals, their associated health effects, quantity information, and a visual risk indicator...
December 13, 2017: Health Communication
https://www.readbyqxmd.com/read/29236537/social-work-s-role-in-medicaid-reform-a-qualitative-study
#9
Sara S Bachman, Madeline Wachman, Leticia Manning, Alexander M Cohen, Robert W Seifert, David K Jones, Therese Fitzgerald, Rachel Nuzum, Patricia Riley
OBJECTIVES: To critically analyze social work's role in Medicaid reform. METHODS: We conducted semistructured interviews with 46 stakeholders from 10 US states that use a range of Medicaid reform approaches. We identified participants using snowball and purposive sampling. We gathered data in 2016 and analyzed them using qualitative methods. RESULTS: Multiple themes emerged: (1) social work participates in Medicaid reform through clinical practice, including care coordination and case management; (2) there is a gap between social work's practice-level and systems-level involvement in Medicaid innovations; (3) factors hindering social work's involvement in systems-level practice include lack of visibility, insufficient clarity on social work's role and impact, and too few resources within professional organizations; and (4) social workers need more training in health transformation payment models and policy...
December 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29236206/management-of-slipped-gastric-bands-via-creation-of-a-de-novo-tunnel-and-band-replacement-a-single-centre-experience
#10
Roshani Vijaykumar Patel, Patrick Woodburn, James R A Skipworth, William James Buchanan Smellie
BACKGROUND: A lack of clarity remains over the optimal strategy for the management of laparoscopic adjustable gastric band (LAGB) slippage, which, although rare (around 3% in our experience), can when acute result in obstruction, gastric erosion or ischaemia. Typically, slipped bands are removed acutely. The aim of this study was to explore outcomes following immediate or delayed resiting of slipped LAGBs in a single centre, comparing simple repositioning with retunnelling and replacement...
December 13, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29235270/lamellar-keratoplasty-using-position-guided-surgical-needle-and-m-mode-optical-coherence-tomography
#11
Sungwon Shin, Jung Kweon Bae, Yujin Ahn, Hyeongeun Kim, Geonho Choi, Young-Sik Yoo, Choun-Ki Joo, Sucbei Moon, Woonggyu Jung
Deep anterior lamellar keratoplasty (DALK) is an emerging surgical technique for the restoration of corneal clarity and vision acuity. The big-bubble technique in DALK surgery is the most essential procedure that includes the air injection through a thin syringe needle to separate the dysfunctional region of the cornea. Even though DALK is a well-known transplant method, it is still challenged to manipulate the needle inside the cornea under the surgical microscope, which varies its surgical yield. Here, we introduce the DALK protocol based on the position-guided needle and M-mode optical coherence tomography (OCT)...
December 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29229368/pharmacodynamic-evaluation-of-self-micro-emulsifying-formulation-of-standardized-extract-of-lagerstroemia-speciosa-for-antidiabetic-activity
#12
Vipin Kumar Agarwal, Gupta Amresh, Phool Chandra
BACKGROUND: Lagerstroemia speciosa (SEL) leaves are a popular folk medicine for diabetes treatment due to presence of corosolic acid. It has low water solubility resulting poor absorption after oral administration. Self micro-emulsified drug delivery system is the way by which we can improve the oral absorption of drug. OBJECTIVE: The objective of this study was to develop the self micro-emulsifying formulation of standardized extract of SEL leaves and evaluate its pharmacodynamic performance for antidiabetic activity...
December 8, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29228134/genotype-specific-measles-transmissibility-a-branching-process-analysis
#13
S F Ackley, J K Hacker, W T A Enanoria, L Worden, S Blumberg, T C Porco, J Zipprich
Background: Substantial heterogeneity in measles outbreak sizes may be due to genotype- specific transmissibility. Using a branching process analysis, we characterize differences in measles transmission by estimating the association between genotype and the reproduction num- ber R among post-elimination California measles cases from 2000-2015 (400 cases, 165 outbreaks). Methods: Assuming a negative binomial secondary case distribution, we fit a branching process model to the distribution of outbreak sizes using maximum likelihood and estimated the effective reproduction number R for a multi-genotype model...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29227554/simple-and-rapid-tissue-clearing-method-for-three-dimensional-histology-of-the-pancreas
#14
Hang Sheung Wong, Patrick Ka Kit Yeung, Hei Ming Lai, Karen Siu Ling Lam, Wu Wutian, Sookja Kim Chung
Previously, high-resolution three-dimensional imaging of a whole and intact pancreas was not possible, since light is scattered when it passes through cell compartments with different refractive indices. CLARITY is one of the tissue clearing techniques that has yielded success with the central nervous system. To preserve tissue integrity after delipidation, conventional protocols embed tissue in an acrylamide-based hydrogel, which involves the use of specialized equipment. Recently, we determined that the hydrogel-embedding step could be simplified and replaced by passive tissue fixation in 4% paraformaldehyde (PFA)...
December 11, 2017: Current Protocols in Cell Biology
https://www.readbyqxmd.com/read/29225766/on-the-discovery-of-monocular-rivalry-by-tscherning-in-1898-translation-and-review
#15
Robert P O'Shea, Urte Roeber, Nicholas J Wade
Monocular rivalry was named by Breese in 1899. He made prolonged observation of superimposed orthogonal gratings; they fluctuated in clarity with either one or the other grating occasionally being visible alone. A year earlier, Tscherning observed similar fluctuations with a grid of vertical and horizontal lines and with other stimuli; we draw attention to his prior account. Monocular rivalry has since been shown to occur with a wide variety of superimposed patterns with several independent rediscoveries of it...
November 2017: I-Perception
https://www.readbyqxmd.com/read/29225457/corneal-regeneration-by-induced-human-buccal-mucosa-cultivated-on-an-amniotic-membrane-following-alkaline-injury
#16
Rohaina Che Man, Then Kong Yong, Ng Min Hwei, Wan Haslina Wan Abdul Halim, Aida Zairani Mohd Zahidin, Roszalina Ramli, Aminuddin Bin Saim, Ruszymah Binti Hj Idrus
Various clinical disorders and injuries, such as chemical, thermal, or mechanical injuries, may lead to corneal loss that results in blindness. PURPOSE: The aims of this study were to differentiate human buccal mucosa (BMuc) into corneal epithelial-like cells, to fabricate engineered corneal tissue using buccal mucosal epithelial cells, and to reconstruct a damaged corneal epithelium in a nude rat model. Methods: BMuc were subjected to 10 d of induction factors to investigate the potential of cells to differentiate into corneal lineages...
2017: Molecular Vision
https://www.readbyqxmd.com/read/29224511/measuring-and-improving-student-engagement-in-clinical-training
#17
Simin Lee, Yannis K Valtis, Tomi Jun, David Wang, Biqi Zhang, Esther H Chung, Amy Yu, Rachael Williams, Marya J Cohen
Purpose Volunteer service learning activities, including Student Run Clinics (SRCs), are becoming an increasingly popular extracurricular component of medical education. While there are reports that student clinicians generally enjoy their educational experiences at SRCs, it is not understood how to optimize and measure student engagement in them. To identify key drivers of student engagement a tool was created to measure volunteer experience at the Crimson Care Collaborative (CCC), a primary care SRC. Methods CCC volunteers were asked to complete an online engagement survey...
December 11, 2017: Education for Primary Care
https://www.readbyqxmd.com/read/29224034/noninvasive-body-contouring
#18
Nicole Y Lee, Deanne Mraz Robinson
In a society where stigma surrounds cosmetic procedures and yet a thin and sculpted physique is idealized, noninvasive body contouring satisfies the demand to reduce excess and undesired body fat in areas that persist despite exercise and diet. Numerous devices are available to meet this need; however, choosing the "perfect" device is challenging because the science and data are often limited with variable results. In this paper, we review 7 US Food and Drug Administration-approved noninvasive body contouring therapies in hopes of providing some clarity to this area...
December 2017: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29223720/serum-periostin-is-associated-with-body-mass-index-and-allergic-rhinitis-in-healthy-and-asthmatic-subjects
#19
Hirokazu Kimura, Satoshi Konno, Hironi Makita, Natsuko Taniguchi, Hiroki Kimura, Houman Goudarzi, Kaoruko Shimizu, Masaru Suzuki, Noriharu Shijubo, Katsunori Shigehara, Junya Ono, Kenji Izuhara, Yoichi Minagawa Ito, Masaharu Nishimura
BACKGROUND: Many studies have attempted to clarify the factors associated with serum periostin levels in asthmatic patients. However, these results were based on studies of subjects mainly characterized by high eosinophil counts, which may present as an obstacle for clarification in the identification of other factors associated with serum periostin levels. The aim of this study was to determine the factors associated with serum periostin levels in healthy subjects. We also assessed some factors in asthmatic subjects to confirm their extrapolation for management of asthma...
December 6, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29223441/edoxaban-for-the-management-of-elderly-japanese-patients-with-atrial-fibrillation-ineligible-for-standard-oral-anticoagulant-therapies-rationale-and-design-of-the-eldercare-af-study
#20
Ken Okumura, Gregory Y H Lip, Masaharu Akao, Kimihiko Tanizawa, Masayuki Fukuzawa, Kenji Abe, Masahiro Akishita, Takeshi Yamashita
Edoxaban-a non-vitamin K antagonist oral anticoagulant (NOAC)- 60-mg and 30-mg once-daily dose regimens are noninferior versus well-managed warfarin for the prevention of stroke or systemic embolic events (SEE) with less major bleeding in patients with nonvalvular atrial fibrillation (NVAF). There are no published data from phase 3 clinical trials specifically evaluating the use of NOACs in elderly NVAF patients, especially those considered ineligible for available oral anticoagulants. The Edoxaban Low-Dose for EldeR CARE AF patients (ELDERCARE-AF) study is a phase 3, randomized, double-blind, placebo-controlled, parallel-group, multicenter study that will compare the safety and efficacy of once-daily edoxaban 15 mg versus placebo in Japanese patients with NVAF ≥80 years of age who are considered ineligible for standard oral anticoagulant therapy...
December 2017: American Heart Journal
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