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https://www.readbyqxmd.com/read/29334523/not-a-straight-line-patient-s-experiences-of-prostate-cancer-and-their-journey-through-the-healthcare-system
#1
Kristina Schildmeijer, Oscar Frykholm, Åsa Kneck, Mirjam Ekstedt
BACKGROUND: Cancer and its treatment can severely impact quality of life, giving rise to complex needs with respect to follow-up care. To support patient needs and increase efficiency of care with limited resources, the Swedish government has launched national reforms to redesign cancer care pathways. OBJECTIVE: The aim of this study was to explore how prostate cancer patients experience their journey through the healthcare system when their care is provided according to the standardized care pathway, as described in healthcare policy documents...
January 12, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29334333/are-people-at-high-risk-for-diabetes-visiting-health-facility-for-confirmation-of-diagnosis-a-population-based-study-from-rural-india
#2
Nikhil Srinivasapura Venkateshmurthy, Kathirvel Soundappan, Balaji Gummidi, Malipeddi Bhaskara Rao, Nikhil Tandon, K Srinath Reddy, Dorairaj Prabhakaran, Sailesh Mohan
BACKGROUND: India is witnessing a rising burden of type 2 diabetes mellitus. India's National Programme for Prevention and Control of Diabetes, Cancer, Cardiovascular diseases and Stroke recommends population-based screening and referral to primary health centre for diagnosis confirmation and treatment initiation. However, little is known about uptake of confirmatory tests among screen positives. OBJECTIVE: To estimate the uptake of confirmatory tests and identify the reasons for not undergoing confirmation by those at high risk for developing diabetes...
2018: Global Health Action
https://www.readbyqxmd.com/read/29334237/safety-of-working-patterns-among-uk-neuroradiologists-what-can-we-learn-from-the-aviation-industry-and-cognitive-science
#3
John Reicher, Stuart Currie, Daniel Birchall
As the volume and complexity of imaging in the UK continues to rise, there is pressure on radiologists to spend increasing lengths of time reporting to cope with the growing workload. However, there is limited guidance for radiologists about structuring the working day to achieve the necessary balance between satisfactory reporting volume and maintaining quality and safety. We surveyed 86 Neuroradiologists (receiving 59 responses), regarding time spent reporting, frequency and duration of work breaks, and break activities...
January 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29333941/intraoperative-complications-and-mid-term-follow-up-of-large-diameter-head-metal-on-metal-total-hip-arthroplasty-and-hip-resurfacing-arthroplasty
#4
S S A Miettinen, T J Mäkinen, K Mäkelä, H Huhtala, J S Kettunen, V Remes
BACKGROUND AND AIMS: Large-diameter head total hip arthroplasty and hip resurfacing arthroplasty were popular in Finland from 2000 to 2012 for the treatment of hip osteoarthritis. The aim of this retrospective study was to investigate the mid-term survival of large-diameter head total hip arthroplasty patients operated on in three university hospitals and to compare these results to the survival of hip resurfacing arthroplasty patients. MATERIAL AND METHODS: A total of 3860 hip arthroplasties (3029 large-diameter head total hip arthroplasties in 2734 patients and 831 hip resurfacing arthroplasties in 757 patients) were operated on between January 2004 and December 2009...
January 1, 2018: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/29333031/a-case-of-multifocal-eosinophilic-granuloma-involving-spine-and-pelvis-in-a-young-adult-a-radiopathological-correlation
#5
Santosh Rai, H B Sridevi, Radha R Pai, Pulastya Sanyal
We present a case of multiple osteolytic lesions in a 28-year-old adult who presented with headache, back pain, and hip pain of 6 months. There was no history of localized swelling or rise of temperature, no history of weight loss or evening rise of temperature. On examination, there were no focal neurological deficits. Routine laboratory investigations, including total leukocyte counts, differential leukocyte counts, hemoglobin, and platelet counts, were within normal limits. There was a borderline elevation of erythrocyte sedimentation rate...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29332675/sleep-duration-and-incidence-of-type-2-diabetes-the-multiethnic-cohort
#6
Gertraud Maskarinec, Simone Jacobs, Yvette Amshoff, Veronica W Setiawan, Yurii B Shvetsov, Adrian A Franke, Laurence N Kolonel, Christopher A Haiman, Loïc Le Marchand
OBJECTIVES: As an emerging risk factor for the rising incidence of type 2 diabetes, we examined sleep duration in relation to type 2 diabetes and several biomarkers. DESIGN: Prospective cohort recruited 1993-1996. SETTING: The Multiethnic Cohort in Hawaii and California. PARTICIPANTS: A cohort of 151,691 White, African American, Japanese American, Native Hawaiian, and Latino participants; 9695 cohort members had biomarker measurements...
February 2018: Sleep Health
https://www.readbyqxmd.com/read/29330314/developmental-disability-at-school-age-and-difficulty-obtaining-follow-up-data
#7
Lex W Doyle, Peter J Anderson, Alice Burnett, Catherine Callanan, Marion McDonald, Marie Hayes, Gillian Opie, Elizabeth Carse, Jeanie L Y Cheong
BACKGROUND: The relationship of developmental disability rates with difficulty obtaining follow-up data is unclear. With this study, we aimed to determine if children who attended research follow-up assessments with more difficulty had more disability at school age, compared with those who attended with less difficulty, and to establish the relationship between follow-up and disability rates. METHODS: Two groups, comprising 219 consecutive survivors born at <28 weeks' gestation or at <1000 g birth weight in the state of Victoria, Australia, in 2005, and 218 term-born, normal birth weight controls were assessed at 8 years of age for neurodevelopmental disability (any of IQ <-1 SD, cerebral palsy, blindness, or deafness)...
January 12, 2018: Pediatrics
https://www.readbyqxmd.com/read/29330216/is-placebo-response-in-antidepressant-trials-rising-or-not-a-reanalysis-of-datasets-to-conclude-this-long-lasting-controversy
#8
REVIEW
Toshi A Furukawa, Andrea Cipriani, Stefan Leucht, Lauren Z Atkinson, Yusuke Ogawa, Nozomi Takeshima, Yu Hayasaka, Anna Chaimani, Georgia Salanti
It had long been believed that placebo response rates in antidepressant trials have been increasing and that they were responsible for rising numbers of so-called failed antidepressant trials. Two recent systematic reviews examined this issue and reached completely opposite findings. Furukawa and colleagues in a paper published in 2016 found that the placebo response rates are stable since 1991 and the apparent increase up to 2000 was confounded by changes in trial design features. By contrast, Khan and colleagues more recently concluded that placebo response rates had grown steadily in the past 30 years...
January 12, 2018: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29325603/culture-conditions-affect-ca2-release-in-artificially-activated-mouse-and-human-oocytes
#9
Yuechao Lu, Davina Bonte, Minerva Ferrer-Buitrago, Mina Popovic, Jitesh Neupane, Margot Van der Jeught, Luc Leybaert, Petra De Sutter, Björn Heindryckx
Inconsistent fertilisation and pregnancy rates have been reported by different laboratories after application of ionomycin as a clinical method of assisted oocyte activation (AOA) to overcome fertilisation failure. Using both mouse and human oocytes, in the present study we investigated the effects of ionomycin and Ca2+ concentrations on the pattern of Ca2+ release and embryonic developmental potential. In the mouse, application of 5μM ionomycin in potassium simplex optimisation medium (KSOM) or 10µM ionomycin in Ca2+-free KSOM significantly reduced the Ca2+ flux and resulted in failure of blastocyst formation compared with 10μM ionomycin in KSOM...
January 12, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29325409/all-health-partnerships-great-and-small-comparing-mandated-with-emergent-health-partnerships-comment-on-evaluating-global-health-partnerships-a-case-study-of-a-gavi-hpv-vaccine-application-process-in-uganda
#10
Elaine Green, Dan Ritman, Graeme Chisholm
The plurality of healthcare providers and funders in low- and middle-income countries (LMICs) has given rise to an era in which health partnerships are becoming the norm in international development. Whether mandated or emergent, three common drivers are essential for ensuring successful health partnerships: trust; a diverse and inclusive network; and a clear governance structure. Mandated and emergent health partnerships operate as very different models and at different scales. However, there is potential for sharing and learning between these types of partnerships...
June 11, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/29324894/the-obesity-epidemic-and-rising-diabetes-incidence-in-a-low-income-racially-diverse-southern-us-cohort
#11
Baqiyyah N Conway, Xijing Han, Heather M Munro, Amy L Gross, Xiao-Ou Shu, Margaret K Hargreaves, Wei Zheng, Alvin C Powers, William J Blot
BACKGROUND: Obesity is known to be a major risk factor for diabetes, but the magnitude of risk and variation between blacks and whites are less well documented in populations heavily affected by obesity. Herein we assess rates and risks of incident diabetes in a diverse southern population where obesity is common. METHODS: A total of 24,000 black and 14,064 white adults aged 40-79 in the Southern Community Cohort Study with no self-reported diabetes at study enrollment during 2002-2009 was followed for up to 10 (median 4...
2018: PloS One
https://www.readbyqxmd.com/read/29323069/recurrent-dermatophytosis-a-rising-problem-in-sikkim-a-himalayan-state-of-india
#12
Rekha Sharma, Luna Adhikari, Rukma Lall Sharma
Changing pattern of dermatophytic infection among people of Sikkim over the past few years and its recurrence rate has brought a need to do a study on clinical pattern and its recurrence from this part of the country. The objectives of this study are to discern the clinical patterns of dermatophytosis, identification of the isolated fungi to its species level and to see the pattern of its recurrence. The study was carried out from January 2015 to May 2016. A total of 192 samples were collected from the patients with clinical findings of dermatophytic infection...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29322775/the-effect-of-metal-doping-and-vacancies-on-the-thermal-conductivity-of-monolayer-molybdenum-diselenide
#13
Milad Yarali, Hatem Brahmi, Zhequan Yan, Xufan Li, Lixin Xie, Shuo Chen, Satish Kumar, Mina Yoon, Kai Xiao, Anastassios Mavrokefalos
It is well understood that defect engineering can give rise to exotic electronic properties in transition metal dichalcogenides, but to this date, there is no detailed study to illustrate how defects can be engineered to tailor their thermal properties. Here, through combined experimental and theoretical approaches based on the first-principles density functional theory and Boltzmann transport equations we have explored the effect of lattice vacancies and substitutional tungsten (W) doping on the thermal transport of the suspended molybdenum diselenide (MoSe2) monolayers grown by chemical vapor deposition (CVD)...
January 11, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29321107/can-i-send-this-patient-with-stroke-home-strategies-managing-transient-ischemic-attack-and-minor-stroke-in-the-emergency-department
#14
Bernard P Chang, Sara Rostanski, Joshua Willey, Benjamin Kummer, Eliza Miller, Mitchell Elkind
BACKGROUND: While transient ischemic attack and minor stroke (TIAMS) are common conditions evaluated in the emergency department (ED), there is controversy regarding the most effective and efficient strategies for managing them in the ED. Some patients are discharged after evaluation in the ED and cared for in the outpatient setting, while others remain in an observation unit without being admitted or discharged, and others experience prolonged and potentially costly inpatient admissions...
January 8, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29320847/new-insights-into-the-role-of-renal-resident-cells-in-the-pathogenesis-of-lupus-nephritis
#15
Seung-Ki Kwok, George C Tsokos
Systemic lupus erythematosus (SLE), an autoimmune disease of unknown etiology, is characterized by the production of autoantibodies and end-organ damage. Lupus nephritis affects up to 70% of patients with SLE and is the most critical predictor of morbidity and mortality. The immunopathogenesis of SLE is complex and most clinical trials of biologics targeting immune cells or their mediators have failed to show efficacy in SLE patients. It has therefore become increasingly clear that additional, local factors give rise to the inflammation and organ damage...
January 12, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29319075/ultrafast-dynamics-of-the-esipt-photoswitch-n-3-pyridinyl-2-pyridinecarboxamide
#16
Hendrik Böhnke, Julia Bahrenburg, Xiaonan Ma, Katharina Röttger, Christian Näther, Michał F Rode, Andrzej L Sobolewski, Friedrich Temps
Molecular switches based on proton transfer that are photochromic and can be interconverted by light at different wavelengths back and forth between two thermodynamically stable tautomeric states in solution at room temperature are rare to date. We report on a study of the ultrafast conversion of the bistable proton transfer switch N-(3-pyridinyl)-2-pyridinecarboxamide (NPPCA) to a corresponding iminol after photoexcitation at λpump ≈ 265 nm by means of femtosecond time-resolved broad-band and single-colour transient electronic absorption spectroscopy (TEAS), transient fluorescence spectroscopy (TFLS), and transient vibrational absorption spectroscopy (TVAS) in acetonitrile solution...
January 10, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29318932/decreased-taurine-and-creatine-in-the-thalamus-may-relate-to-behavioral-impairments-in-ethanol-fed-mice-a-pilot-study-of-proton-magnetic-resonance-spectroscopy
#17
Su Xu, Wenjun Zhu, Yamin Wan, JiaBei Wang, Xi Chen, Liya Pi, Mary Kay Lobo, Bin Ren, Zhekang Ying, Michael Morris, Qi Cao
Minimal hepatic encephalopathy (MHE) is highly prevalent, observed in up to 80% of patients with liver dysfunction. Minimal hepatic encephalopathy is defined as hepatic encephalopathy with cognitive deficits and no grossly evident neurologic abnormalities. Clinical management may be delayed due to the lack of in vivo quantitative methods needed to reveal changes in brain neurobiochemical biomarkers. To gain insight into the development of alcoholic liver disease-induced neurological dysfunction (NDF), a mouse model of late-stage alcoholic liver fibrosis (LALF) was used to investigate changes in neurochemical levels in the thalamus and hippocampus that relate to behavioral changes...
January 2018: Molecular Imaging
https://www.readbyqxmd.com/read/29318451/bringing-the-national-security-agency-into-the-classroom-ethical-reflections-on-academia-intelligence-agency-partnerships
#18
Christopher Kampe, Gwendolynne Reid, Paul Jones, Colleen S, Sean S, Kathleen M Vogel
Academia-intelligence agency collaborations are on the rise for a variety of reasons. These can take many forms, one of which is in the classroom, using students to stand in for intelligence analysts. Classrooms, however, are ethically complex spaces, with students considered vulnerable populations, and become even more complex when layering multiple goals, activities, tools, and stakeholders over those traditionally present. This does not necessarily mean one must shy away from academia-intelligence agency partnerships in classrooms, but that these must be conducted carefully and reflexively...
January 9, 2018: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29317235/differentiating-breast-carcinoma-with-signet-ring-features-from-gastrointestinal-signet-ring-carcinoma-assessment-of-immunohistochemical-markers
#19
Yiang Hui, Yihong Wang, Gahie Nam, Jacqueline Fanion, Ashlee Sturtevant, Kara A Lombardo, Murray B Resnick
Signet-ring morphology is recognized throughout the gastrointestinal tract. However, this pattern may be observed in other primary sites giving rise to diagnostic challenges in the work-up of metastases. Relatively newer immunohistochemical markers have not been evaluated in this context. We assessed expression patterns of several common immunohistochemical markers in tumors with signet-ring morphology to delineate a pragmatic approach to this differential diagnosis. Primary breast and gastrointestinal carcinomas showing signet-ring features were reviewed...
January 6, 2018: Human Pathology
https://www.readbyqxmd.com/read/29317175/premature-progesterone-rise-in-art-cycles
#20
REVIEW
B Lawrenz, L Melado, H M Fatemi
Premature rise of progesterone during the late follicular phase in stimulated IVF cycles is a frequent event and its effect on the endometrial receptivity and on the ART (Assisted Reproductive Technique) - outcome has become a matter of intense debate and research. An emerging body of evidence demonstrates that premature progesterone rise does have a negative impact on the outcome of the ART-success. Until now, the exact cause of progesterone elevation is not fully clear, however lately published studies points to the fact, that premature progesterone elevation might be caused by enhanced FSH stimulation...
January 6, 2018: Reproductive Biology
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