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https://www.readbyqxmd.com/read/28938520/galangin-suppresses-hepatocellular-carcinoma-cell-proliferation-by-reversing-the-warburg-effect
#1
Yajun Wang, Biyun Lin, Huimin Li, Liubo Lan, Huajun Yu, Shang Wu, Jun Wu, Haitao Zhang
Hepatocellular carcinoma (HCC) is the sixth most common cancer. The Warburg effect is an important way by which HCC adapts to a hypoxic environment. The aim of the present study was to determine whether and how galangin reverses the Warburg effect in HCC cells. We treated three HCC cell lines, HepG2, Hep3B and PLC/PRF/5 with galangin for 24h, respectively. Cell proliferation was measured with MTT assay. Glucose uptake, lactate production and the oxygen consumption were measured. Pyruvate kinase activities were detected by measuring the consumption of NADH, and glycolytic pathway-related proteins were measured by Western blotting...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28938264/2016-neonatal-nurse-practitioner-workforce-survey-report-of-findings
#2
Suzanne Staebler, Robin Bissinger
The National Association of Neonatal Nurse Practitioners (NANNP) conducted its second workforce survey of certified neonatal nurse practitioners in the fall of 2016. National Association of Neonatal Nurse Practitioners partnered with the National Certification Corporation and the American Association of Nurse Practitioners to conduct this electronic survey, containing 69 questions and focusing on practice sites and total compensation packages (including benefits) and workforce deficits.Findings indicate a rising neonatal nurse practitioners (NNPs) position vacancy rate across the country...
October 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/28937587/%C3%A2%C2%B5-conotoxins-modulating-sodium-currents-in-pain-perception-and-transmission-a-therapeutic-potential
#3
REVIEW
Elisabetta Tosti, Raffaele Boni, Alessandra Gallo
The Conus genus includes around 500 species of marine mollusks with a peculiar production of venomous peptides known as conotoxins (CTX). Each species is able to produce up to 200 different biological active peptides. Common structure of CTX is the low number of amino acids stabilized by disulfide bridges and post-translational modifications that give rise to different isoforms. µ and µO-CTX are two isoforms that specifically target voltage-gated sodium channels. These, by inducing the entrance of sodium ions in the cell, modulate the neuronal excitability by depolarizing plasma membrane and propagating the action potential...
September 22, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28937372/age-related-reference-intervals-for-immunoglobulin-levels-and-lymphocyte-subsets-in-indian-children
#4
Gaurav Narula, Shanaz Khodaiji, Arun Bableshwar, Manjeet Singh Bindra
BACKGROUND: In children, innate and adaptive immunity varies with age, disease status, and ethnicity, reflected by lymphocyte subsets and serum immunoglobulin (Ig) levels. The paucity of such data from the Indian subcontinent necessitated this study. AIMS: This study aims to determine reference ranges of Ig and lymphocyte subsets in Indian children from birth to 5 years. SETTINGS AND DESIGN: Neonates, infants, and children from a tertiary care hospital were selected and categorized into 5 groups from cord blood/newborn to 5 years...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28936478/recurrence-rate-of-melanoma-in-situ-when-treated-with-serial-disk-staged-excision-a-case-series
#5
Daniel Garcia, Robert E Eilers, S Brian Jiang
BACKGROUND: Cutaneous melanoma is one of the fastest rising cancer diagnoses in recent years. Melanoma in situ (MIS) constitutes a large proportion of all diagnosed melanomas. While surgical excision is considered the standard of therapy, the literature is not clear on which surgical technique minimizes local recurrence. A common technique is serial staged excision (SSE), in which a series of mapped excisions are made according to histopathological examination of tissue. Previously published recurrence rates for SSE ranges from 0-12%, over a range of 4...
February 2017: Journal of Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28934333/supermarket-purchase-contributes-to-nutrition-related-non-communicable-diseases-in-urban-kenya
#6
Kathrin M Demmler, Stephan Klasen, Jonathan M Nzuma, Matin Qaim
BACKGROUND: While undernutrition and related infectious diseases are still pervasive in many developing countries, the prevalence of non-communicable diseases (NCD), typically associated with high body mass index (BMI), is rapidly rising. The fast spread of supermarkets and related shifts in diets were identified as possible factors contributing to overweight and obesity in developing countries. Potential effects of supermarkets on people's health have not been analyzed up till now. OBJECTIVE: This study investigates the effects of purchasing food in supermarkets on people's BMI, as well as on health indicators such as fasting blood glucose (FBG), blood pressure (BP), and the metabolic syndrome...
2017: PloS One
https://www.readbyqxmd.com/read/28932695/disequilibrium-calorimetry-for-determination-of-ultrasonic-power-in-sonochemistry
#7
Mario Plattes, Christian Köhler, Tom Gallé
The two most characteristic properties of an ultrasonic wave are the frequency and the power. It is therefore important to determine the power in a given reactor. This can be done by calorimetry, i.e. by measuring the temperature rise in the vessel during sonication starting at thermal equilibrium with the surroundings (classic calorimetry) [1-3]. However, the classic ultrasonic calorimetry has drawbacks. In particular it is difficult to evaluate the temperature rise at thermal equilibrium, because the relevant initial time and temperature intervals are small and measurement errors in the temperature readings are large...
2017: MethodsX
https://www.readbyqxmd.com/read/28932498/hemodynamic-effect-of-intravenous-lidocaine-during-aortic-cannulation-in-cardiac-surgery
#8
Ziya Totonchi, Shirin Salajegheh, Mahmoud Reza Mohaghegh, Mehrdad Mesbah Kiaei, Mohammad Shirvani, Masoud Ghorbanlo
BACKGROUND: Dissection of aorta is a rare, but fatal complication of aortic cannulation in cardiac surgery can be caused by the sudden rise in blood pressure and hemodynamic variations. METHODS: In this study, 90 patients aged 18 years or older undergoing cardiac surgery were divided into two equal groups. Under similar conditions, trial group received 1.5 mg/kg of lidocaine for 90 s before cannulation and control group received normal saline. Hemodynamic parameters of patients including systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and central venous pressure before cannulation and 1, 3, and 5 min after cannulation were recorded in a form...
June 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28931988/the-relationship-between-ground-reaction-force-in-sit-to-stand-movement-and-lower-extremity-function-in-community-dwelling-japanese-older-adults-using-long-term-care-insurance-services
#9
Shaoshuai Shen, Takumi Abe, Taishi Tsuji, Keisuke Fujii, Jingyu Ma, Tomohiro Okura
[Purpose] The purpose of this study was to investigate which of the four chair-rising methods has low-load and the highest success rate, and whether the GRF parameters in that method are useful for measuring lower extremity function among physically frail Japanese older adults. [Subjects and Methods] Fifty-two individuals participated in this study. The participants voluntarily attempted four types of Sit-to-stand test (one variation without and three variations with the use of their arms). The following parameters were measured: peak reaction force (F/w), two force development rate parameters (RFD1...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28931601/local-cellular-neighbourhood-controls-proliferation-in-cell-competition
#10
Anna Bove, Daniel Gradeci, Yasuyuki Fujita, Shiladitya Banerjee, Guillaume Charras, Alan R Lowe
Cell competition is a quality control mechanism through which tissues eliminate unfit cells. Cell competition can result from short-range biochemical inductions or long-range mechanical cues. However, little is known about how cell-scale interactions give rise to population shifts in tissues, due to the lack of experimental and computational tools to efficiently characterise interactions at the single-cell level. Here, we address these challenges by combining long-term automated microscopy with deep learning image analysis to decipher how single-cell behaviour determines tissue make-up during competition...
September 20, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28930849/analysis-of-risk-factors-for-colonic-diverticular-bleeding-and-recurrence
#11
Masato Taki, Tadayuki Oshima, Katsuyuki Tozawa, Yukako Taniguchi, Toshihiko Tomita, Yoshio Ohda, Hirokazu Fukui, Jiro Watari, Hiroto Miwa
The increase in incidence of colonic diverticular bleeding is relative to an age-related rise in the incidence of colonic diverticulosis and use of antithrombotic medication. However, risk factors related to the onset, recurrence, and prophylaxis have not been established. Therefore, we aimed to determine risk factors for the onset and recurrence of colonic diverticular bleeding.An age- and sex-matched case-control study was performed to assess the risk factors for the onset of colonic diverticular bleeding...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28928709/insight-into-metabolic-1-h-mrs-changes-in-natalizumab-induced-progressive-multifocal-leukoencephalopathy-brain-lesions
#12
Ruth Schneider, Barbara Bellenberg, Robert Hoepner, Gisa Ellrichmann, Ralf Gold, Carsten Lukas
BACKGROUND: Progressive multifocal leukoencephalopathy (PML) is a severe complication of immunosuppressive therapies, especially of natalizumab in relapsing-remitting multiple sclerosis (MS). Metabolic changes within PML lesions have not yet been described in natalizumab-associated PML in MS patients. OBJECTIVE: To study metabolic profiles in natalizumab-associated PML lesions of MS patients by (1)H magnetic resonance spectroscopy ((1)H-MRS) at different stages during the PML course...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28928183/assessing-the-extent-of-drug-interactions-among-patients-with-multimorbidity-in-primary-and-secondary-care-in-the-west-midlands-uk-a-study-protocol-for-the-mixed-methods-multimorbidity-study-mimms
#13
Ruth Backman, Philip Weber, Alice M Turner, Mark Lee, Ian Litchfield
INTRODUCTION: The numbers of patients with three or more chronic conditions (multimorbidity) are increasing, and will rise to 2.9 million by 2018 in the UK alone. Currently in the UK, conditions are mainly managed using over 250 sets of single-condition guidance, which has the potential to generate conflicting recommendations for lifestyle and concurrent medication for individual patients with more than one condition. To address some of these issues, we are developing a new computer-based tool to help manage these patients more effectively...
September 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28927495/preventing-myopia
#14
Wolf A Lagrèze, Frank Schaeffel
BACKGROUND: Nearsightedness (myopia) has become more common around the world recently, mainly because of changes in visual, educational, and recreational behavior. The question arises how the risk of myopia and its progression can be reduced. This would lessen the prevalence and severity of myopia and also lower the risk of secondary diseases that impair visual acuity. METHODS: The PubMed/Medline database was selectively searched for pertinent literature. RESULTS: The risk of myopia is lowered by exposure to daylight and increased by activities performed at short visual distances (close-up work)...
September 4, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28927191/increasing-mortality-from-ischaemic-heart-disease-in-china-from-2004-to-2010-disproportionate-rise-in-rural-areas-and-elderly-subjects-438-million-person-years-follow-up
#15
Xiaofei Zhang, Arshad A Khan, Ehtesham Ul Haq, Aadil Rahim, Dayi Hu, John Attia, Christopher Oldmeadow, Xiaoyan Ma, Rongjing Ding, Andrew J Boyle
Aims: We sought to ascertain the changes in mortality from ischaemic heart disease (IHD) from 2004 to 2010 in China as the sheer size of China's population makes disease patterns relevant globally. Methods and results: Data on IHD mortality were obtained from the Chinese Centre for Disease Control and Prevention National Disease Surveillance Point System, which includes 161 counties and a population of over 73 million-a representative sample of over 6% of the entire population of China...
January 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28926044/running-out-of-lithium-a-route-to-differentiate-between-capacity-losses-and-active-lithium-losses-in-lithium-ion-batteries
#16
Florian Holtstiege, Andrea Wilken, Martin Winter, Tobias Placke
Active lithium loss (ALL) resulting in a capacity loss (QALL), which is caused by lithium consuming parasitic reactions like SEI formation, is a major reason for capacity fading and, thus, for a reduction of the usable energy density of lithium-ion batteries (LIBs). QALL is often equated with the accumulated irreversible capacity (QAIC). However, QAIC is also influenced by non-lithium consuming parasitic reactions, which do not reduce the active lithium content of the cell, but induce a parasitic current. In this work, a novel approach is proposed in order to differentiate between QAIC and QALL...
September 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28925011/trends-in-active-surveillance-for-very-low-risk-prostate-cancer-do-guidelines-influence-modern-practice
#17
Rahul R Parikh, Sinae Kim, Mark N Stein, Bruce G Haffty, Isaac Y Kim, Sharad Goyal
As recommended by current NCCN guidelines, patients with very low-risk prostate cancer may be treated with active surveillance (AS), but this may be underutilized. Using the National Cancer Database (NCDB), we identified men (2010-2013) with biopsy-proven, very low-risk prostate cancer that met AS criteria as suggested by Epstein (stage ≤ T1c; Gleason score (GS) ≤ 6; PSA < 10; and ≤2 [or <33%] positive biopsy cores) and aged ≤76, and low comorbidity index (Charlson-Deyo score = 0). For those patients meeting this criteria, we performed generalized estimation equation (GEE) method with incorporation of correlation in patients clustered within facility to determine the likelihood of undergoing AS...
September 18, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28923524/mandarin-fish-p53-genomic-structure-alternatively-spliced-variant-and-its-mrna-expression-after-virus-challenge
#18
Huizhi Guo, Xiaozhe Fu, Qiang Lin, Lihui Liu, Hongru Liang, Zhibin Huang, Ningqiu Li, Jianguo Su
A number of size variants of the p53 protein have been described in mammal, but little is known about alternative splicing of p53 expression and function in the fish. In our previous study, the immune defense and antiviral responses of p53 had been determined in mandarin fish (Siniperca chuatsi). However, the role of its splicing variants remains unknown. In the present study, the organization of mandarin fish p53 (Sc-p53) genome sequence was determined and a novel splice variant was characterized. The Sc-p53 genomic sequence was composed of 5543 bp, containing 11 exons and 10 introns, which was similar to other species...
September 16, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28923127/thin-blue-lines-product-placement-and-the-drama-of-pregnancy-testing-in-british-cinema-and-television
#19
Jesse Olszynko-Gryn
This article uses the case of pregnancy testing in Britain to investigate the process whereby new and often controversial reproductive technologies are made visible and normalized in mainstream entertainment media. It shows how in the 1980s and 1990s the then nascent product placement industry was instrumental in embedding pregnancy testing in British cinema and television's dramatic productions. In this period, the pregnancy-test close-up became a conventional trope and the thin blue lines associated with Unilever's Clearblue rose to prominence in mainstream consumer culture...
September 2017: British Journal for the History of Science
https://www.readbyqxmd.com/read/28922811/a-programme-to-create-short-course-chemotherapy-for-pulmonary-mycobacterium-avium-disease-based-on-pharmacokinetics-pharmacodynamics-and-mathematical-forecasting
#20
Devyani Deshpande, Shashikant Srivastava, Tawanda Gumbo
Objectives: Pulmonary Mycobacterium avium complex (MAC) prevalence is on the rise worldwide. The average therapy duration is 1.5 years, which is associated with poor cure rates. Our objective was to develop a programme to design a combination therapy regimen for pulmonary MAC to be administered for 6 months or less with efficacy in > 90% of patients. Methods: We performed a literature search for the following MeSH headings 'Mycobacterium avium' AND 'pharmacokinetics/pharmacodynamics' in PubMed up to 2016...
September 1, 2017: Journal of Antimicrobial Chemotherapy
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