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https://www.readbyqxmd.com/read/27913835/preventive-dna-vaccination-against-cea-expressing-tumors-with-anti-idiotypic-scfv6-c4-dna-in-cea-expressing-transgenic-mice
#1
Priscila M A Denapoli, Bianca F Zanetti, Adara A Dos Santos, Jane Z de Moraes, Sang W Han
Carcinoembryonic antigen (CEA) is expressed during embryonic life and in low level during adult life. Consequently, the CEA is recognized by the immune system as a self-antigen and thus CEA-expressing tumors are tolerated. Previously, we constructed a single chain variable fragment using the 6.C4 (scFv6.C4) hybridoma cell line, which gave rise to antibodies able to recognize CEA when C57/Bl6 mice were immunized. Here, the scFv6.C4 ability to prevent the CEA-expressing tumor growth was assessed in CEA-expressing transgenic mice CEA2682...
December 2, 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27913643/biogenesis-and-transcriptional-regulation-of-long-noncoding-rnas-in-the-human-immune-system
#2
REVIEW
Charles F Spurlock, Philip S Crooke, Thomas M Aune
The central dogma of molecular biology states that DNA makes RNA makes protein. Discoveries over the last quarter of a century found that the process of DNA transcription into RNA gives rise to a diverse array of functional RNA species, including genes that code for protein and noncoding RNAs. For decades, the focus has been on understanding how protein-coding genes are regulated to influence protein expression. However, with the completion of the Human Genome Project and follow-up ENCODE data, it is now appreciated that only 2-3% of the genome codes for protein-coding gene exons and that the bulk of the transcribed genome, apart from ribosomal RNAs, is at the level of noncoding RNA genes...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27913398/cancer-burden-with-ageing-population-in-urban-regions-in-china-projection-on-cancer-registry-data-from-world-health-organization
#3
REVIEW
Kelvin K F Tsoi, Hoyee W Hirai, Felix C H Chan, Sian Griffiths, Joseph J Y Sung
BACKGROUND: China is facing the challenges of an expanding ageing population and the impact of rapid urbanization, cancer rates are subsequently increasing. This study focuses on the changes of the ageing population and projects the incidence of common ageing-related cancers in the urban regions in China up to 2030. SOURCES OF DATA: Cancer incidence data and population statistics in China were extracted from the International Agency for Research on Cancer. AREAS OF AGREEMENT: Due to improving longevity in China, continuous and remarkable increasing trends for the lung, colorectal and prostate cancers are expected...
December 1, 2016: British Medical Bulletin
https://www.readbyqxmd.com/read/27913203/incidence-of-recurrent-intracerebral-hemorrhages-in-a-multiethnic-south-asian-population
#4
Liming Qiu, Trisha Upadhyaya, Angela An Qi See, Yew Poh Ng, Nicolas Kon Kam King
INTRODUCTION: Spontaneous primary intracerebral hemorrhage (ICH) accounts for approximately 25% of all strokes in Singapore. Incidence of recurrent ICH is not well studied, and previous studies have reported inconsistent findings in the rate and risk factors associated with ICH recurrences. We aimed to study the incidence of recurrent ICHs in Singapore and to identify the associated risk factors as well as pattern of ICH recurrence. METHODS: A retrospective review of all consecutive admissions for intracerebral hemorrhage at the National Neuroscience Institute between January 2006 and November 2013 was performed...
November 29, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27910571/a-collimated-neutron-detector-for-rfp-plasmas-in-mst
#5
W J Capecchi, J K Anderson, P J Bonofiglo, J Kim, S Sears
The neutron emissivity profile in the Madison Symmetric Torus is being reconstructed through the use of a collimated neutron detector. A scintillator-photomultiplier tube (PMT) system is employed to detect the fusion neutrons with the plasma viewing volume defined by a 55 cm deep, 5 cm diameter aperture. Effective detection of neutrons from the viewing volume is achieved through neutron moderation using 1300 lbs of high density polyethylene shielding, which modeling predicts attenuates the penetrating flux by a factor of 10(4) or more...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910434/experiments-of-a-monolithic-radial-transmission-line
#6
C Mao, X Wang, X Zou, J Lehr
This paper presents the experimental results of a monolithic radial transmission line (MRTL) that may be used in pulsed power generators and microwave devices. The MRTL with a hyperbolic impedance profile is 508 mm in radius, corresponding to a one-way transit time of 15 ns for the electromagnetic wave. In the experiments, up to twenty identical voltage pulses, 10 ns in FWHM and 2 ns in rise-time, were fed into the MRTL through 20 input BNC connectors that are uniformly distributed along the outer circumference of the MRTL...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910085/sprint-fidelis-implantable-cardioverter-defibrillators-lead-patient-management-and-survival-single-center-study
#7
Marcin Grabowski, Jakub Kosma Rokicki, Sylwia Gajda, Łukasz Januszkiewicz, Andrzej Cacko, Przemysław Stolarz, Grzegorz Opolski
BACKGROUND: Over the last several years significant rises in the use of implanted cardioverter-defibrillators (ICD) have also resulted in a number of associated complications. This number includes lead failure. Sprint Fidelis ICD lead (SF) is regarded as a lead with elevated failure risk. Every center acting in accordance with the guidelines should observe patients more thoroughly especially with recalled leads and run a registry of their follow-up. The aim of the present research was to observe patients with SF leads (types 6948, 6949) from a single implantation center...
December 2, 2016: Cardiology Journal
https://www.readbyqxmd.com/read/27909444/smallholder-farms-and-the-potential-for-sustainable-intensification
#8
Leah M Mungai, Sieglinde Snapp, Joseph P Messina, Regis Chikowo, Alex Smith, Erin Anders, Robert B Richardson, Guiying Li
The sustainable intensification of African agriculture is gaining momentum with the compelling need to increase food and agricultural production. In Southern Africa, smallholder farming systems are predominately maize-based and subject to erratic climatic conditions. Farmer crop and soil management decisions are influenced by a plethora of complex factors such as market access resource availability, social relations, environment, and various messages on sustainable farming practices. Such factors pose barriers to increasing sustainable intensification in Africa...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27908703/simultaneous-effects-of-coagulation-and-variable-magnetic-field-on-peristaltically-induced-motion-of-jeffrey-nanofluid-containing-gyrotactic-microorganism
#9
M M Bhatti, A Zeeshan, R Ellahi
In this article, simultaneous effects of coagulation (blood clot) and variable magnetic field on peristaltically induced motion of non-Newtonian Jeffrey nanofluid containing gyrotactic microorganism through an annulus have been studied. The effects of an endoscope also taken into consideration in our study as a special case. The governing flow problem is simplified by taking the approximation of long wavelength and creeping flow regime. The resulting highly coupled differential equations are solved analytically with the help of perturbation method and series solution have been presented up to second order approximation...
November 28, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27908459/three-single-leg-standing-tests-for-clinical-assessment-of-chronic-plantar-heel-pain-syndrome-static-stance-half-squat-and-heel-rise
#10
B Saban, Y Masharawi
OBJECTIVE: To assess reliability and validity of three single leg standing clinical tests in patients with plantar heel pain syndrome (PHPS). DESIGN: Cross-sectional reliability study. PARTICIPANTS: Forty patients diagnosed with PHPS. MAIN OUTCOME MEASURES: Patients stood on their affected foot in a static stance for up to 30seconds, a half squat for up to 10 repetitions, and a heel rise for up to 10 repetitions. The first sensation of pain (p1) determined the termination of each test, and established a positive test result...
June 29, 2016: Physiotherapy
https://www.readbyqxmd.com/read/27907906/senescent-fibroblast-derived-chemerin-promotes-squamous-cell-carcinoma-migration
#11
Vida Farsam, Abhijit Basu, Martina Gatzka, Nicolai Treiber, Lars A Schneider, Medhanie A Mulaw, Tanja Lucas, Stefan Kochanek, Reinhard Dummer, Mitchell P Levesque, Meinhard Wlaschek, Karin Scharffetter-Kochanek
Aging is associated with a rising incidence of cutaneous squamous cell carcinoma (cSCC), an aggressive skin cancer with the potential for local invasion and metastasis. Acquisition of a senescence-associated secretory phenotype (SASP) in dermal fibroblasts has been postulated to promote skin cancer progression in elderly individuals. The underlying molecular mechanisms are largely unexplored. We show that Chemerin, a previously unreported SASP factor released from senescent human dermal fibroblasts, promotes cSCC cell migration, a key feature driving tumor progression...
November 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27906881/stem-cells-and-clinical-practice-new-advances-and-challenges-at-the-time-of-emerging-problems-with-induced-pluripotent-stem-cell-therapies
#12
Mariusz Z Ratajczak, Kamila Bujko, Wojciech Wojakowski
Humans, like other species that reproduce sexually, originate from a fertilized oocyte (zygote), which is a totipotent stem cell giving rise to an adult organism. During the process of embryogenesis, stem cells at different levels of the developmental hierarchy establish all 3 germ layers and give rise to tissue‑committed stem cells, which are responsible for rejuvenation of a given tissue or organ. The robustness of the stem cell compartment is one of the major factors that directly impact life quality as well as lifespan...
November 10, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27905895/mortality-along-the-continuum-of-hiv-care-in-rwanda-a-model-based-analysis
#13
Eran Bendavid, David Stauffer, Eric Remera, Sabin Nsanzimana, Steve Kanters, Edward J Mills
BACKGROUND: HIV is the leading cause of death among adults in sub-Saharan Africa. However, mortality along the HIV care continuum is poorly described. We combine demographic, epidemiologic, and health services data to estimate where are people with HIV dying along Rwanda's care continuum. METHODS: We calibrated an age-structured HIV disease and transmission stochastic simulation model to the epidemic in Rwanda. We estimate mortality among HIV-infected individuals in the following states: untested, tested without establishing care in an antiretroviral therapy (ART) program (unlinked), in care before initiating ART (pre-ART), lost to follow-up (LTFU) following ART initiation, and retained in active ART care...
December 1, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27905835/hemagglutination-inhibiting-antibody-persistence-1-year-after-of-influenza-vaccination-in-korean-children-and-adolescents
#14
Eun-Kyeong Kang, Byung-Wook Eun, Nam-Hee Kim, Yun-Kyung Kim, Jung-Sub Lim, Dong-Ho Kim
This study aimed to assess the one-year immunogenicity of influenza vaccines and the association between immunogenicity at one month and further influenza infections in children aged 6 months to 18 years. Serum hemagglutination inhibition (HI) antibody titers and GMTs were determined for the recommended influenza strains 0, 1, 6, and 12 months post-vaccination. The serological evidence of influenza infections were defined as the increase of HI titer (HI ≥1:40 and 4-fold rise). The seroprotection rates for strains A(H1N1), A(H3N2), and B were 91...
December 1, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27904863/recent-updates-in-the-endoscopic-diagnosis-of-barrett-s-oesophagus
#15
REVIEW
Neel Sharma, Khek Yu Ho
BACKGROUND: Barrett's oesophagus (BO) is a premalignant condition associated with the development of oesophageal adenocarcinoma (OAC). Despite the low risk of progression per annum, OAC is associated with significant morbidity and mortality, with an estimated 5-year survival of 10%. Furthermore, the incidence of OAC continues to rise globally. Therefore, it is imperative to detect the premalignant phase of BO and follow up such patients accordingly. SUMMARY: The mainstay diagnosis of BO is endoscopy and biopsy sampling...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27904748/patterns-of-medication-use-and-factors-associated-with-antibiotic-use-among-adult-fever-patients-at-singapore-primary-care-clinics
#16
Zaw Myo Tun, Mahesh Moorthy, Martin Linster, Yvonne C F Su, Richard James Coker, Eng Eong Ooi, Jenny Guek-Hong Low, Gavin J D Smith, Clarence C Tam
BACKGROUND: Antimicrobial resistance is a public health problem of global importance. In Singapore, much focus has been given to antibiotic usage patterns in hospital settings. Data on antibiotic use in primary care is lacking. We describe antibiotic usage patterns and assess factors contributing to antibiotic usage among adults presenting with acute febrile illness (AFI) in primary care settings in Singapore. METHODS: We analyzed data from the Early Dengue infection and outcome study...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27904417/global-warming-and-the-possible-globalization-of-vector-borne-diseases-a-call-for-increased-awareness-and-action
#17
Emmanuel O Balogun, Andrew J Nok, Kiyoshi Kita
Human activities such as burning of fossil fuels play a role in upsetting a previously more balanced and harmonious ecosystem. Climate change-a significant variation in the usual pattern of Earth's average weather conditions is a product of this ecosystem imbalance, and the rise in the Earth's average temperature (global warming) is a prominent evidence. There is a correlation between global warming and the ease of transmission of infectious diseases. Therefore, with global health in focus, we herein opine a stepping-up of research activities regarding global warming and infectious diseases globally...
2016: Tropical Medicine and Health
https://www.readbyqxmd.com/read/27904089/structure-cytotoxicity-relationship-of-methacrylate-based-resin-monomers-as-evaluated-by-an-anti-oxidant-responsive-element-luciferase-reporter-assay
#18
Miki Egashira, Takahiro Suzuki, Ai Orimoto, Tohru Obata, Hiroshi Nakamura, Motohiro Tanaka, Takao Kanamori, Tatsushi Kawai
To investigate the chemical structure-cytotoxicity relationship of methacrylate-based resin monomers, we studied their effects on anti-oxidant responsive element (ARE)-mediated transcription. HepG2 cells stably expressing an ARE-regulated luciferase reporter gene were cultured for 6 h with various concentrations of several resin monomers and subjected to a luciferase assay. The doseresponse curves observed for hydrophobic monomers with different hydrocarbon chains (MMA, EMA, PMA and BMA) began to rise at concentrations between 0...
2016: Dental Materials Journal
https://www.readbyqxmd.com/read/27903563/leveraging-ongoing-research-to-evaluate-the-health-impacts-of-south-africa-s-salt-reduction-strategy-a-prospective-nested-cohort-within-the-who-sage-multicountry-longitudinal-study
#19
Karen Charlton, Lisa J Ware, Elias Menyanu, Richard Berko Biritwum, Nirmala Naidoo, Chiné Pieterse, Savathree Lorna Madurai, Jeannine Baumgartner, George A Asare, Elizabeth Thiele, Aletta E Schutte, Paul Kowal
INTRODUCTION: Attempting to curb the rising epidemic of hypertension, South Africa implemented legislation in June 2016 mandating maximum sodium levels in a range of manufactured foods that contribute significantly to population salt intake. This natural experiment, comparing two African countries with and without salt legislation, will provide timely information on the impact of legislative approaches addressing the food supply to improve blood pressure in African populations. This article outlines the design of this ongoing prospective nested cohort study...
November 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/27903513/the-maximum-heart-rate-in-brown-trout-salmo-trutta-fario-is-not-limited-by-firing-rate-of-pacemaker-cells
#20
Jaakko Haverinen, Denis V Abramochkin, Andre Kamkin, Matti Vornanen
Temperature-induced changes in cardiac output (Q) in fish are largely dependent on thermal modulation of heart rate (fH) and at high temperatures Q collapses due to heat-dependent depression of fH This study tests the hypothesis that firing rate of sinoatrial pacemaker cells sets the upper thermal limit of fH in vivo. To this end temperature-dependence of action potential (AP) frequency of enzymatically isolated pacemaker cells (pacemaker rate, fPM), spontaneous beating rate of isolated sinoatrial preparations (fSA) and in vivo heart rate (fH) of the cold-acclimated (4°C) brown trout (Salmo trutta fario) were compared under acute thermal challenges...
November 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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