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https://www.readbyqxmd.com/read/28722168/role-of-palmitoylation-of-cysteine-415-in-functional-coupling-cb1-receptor-to-g%C3%AE-i2-protein
#1
Sergio Oddi, Antonio Totaro, Lucia Scipioni, Beatrice Dufrusine, Tomasz Maciej Stepniewski, Jana Selent, Mauro Maccarrone, Enrico Dainese
In this study, we investigated the role of CB1 palmitoylation in modulating the functional interaction with G proteins both in the absence and in the presence of agonist binding. Our data show that the non-palmitoylated CB1 receptor significantly reduced its association with Gαi2 . The agonist-stimulation induced a partial dissociation of Gαi2 proteins from the wild-type receptor, while on the C415A mutant the agonist binding was not able to induce a significant dissociation of Gαi2 from the receptor. Our data suggest that the lack of palmitoyl chain hampers the ability of the receptor to functionally interact with the Gαi2 and indicate that the palmitoyl chain is responsible for the functional transmission of the agonist-induced conformational change of the receptor to the G protein...
July 19, 2017: Biotechnology and Applied Biochemistry
https://www.readbyqxmd.com/read/28711688/aga-institute-series-focus-on-enhancing-high-value-care-cost-effective-therapy-for-sphincter-of-oddi-dysfunction
#2
Dennis Yang, Patrick Yachimski
No abstract text is available yet for this article.
July 12, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28691687/pancreaticobiliary-maljunction-and-congenital-biliary-dilatation
#3
REVIEW
Terumi Kamisawa, Kenitiro Kaneko, Takao Itoi, Hisami Ando
Pancreaticobiliary maljunction is a congenital malformation in which the pancreatic and bile ducts join outside the duodenal wall, usually forming a long common channel. Because the action of the sphincter of Oddi does not regulate the function of the pancreaticobiliary junction in patients with pancreaticobiliary maljunction, two-way regurgitation occurs. Reflux of pancreatic juice into the biliary tract is associated with a high incidence of biliary cancer. Biliary carcinogenesis in patients with pancreaticobiliary maljunction is thought to follow the hyperplasia, dysplasia, then carcinoma sequence due to chronic inflammation caused by pancreatobiliary reflux...
August 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28659295/infant-feeding-and-growth-trajectory-patterns-in-childhood-and-body-composition-in-young-adulthood
#4
Peter Rzehak, Wendy H Oddy, M Luisa Mearin, Veit Grote, Trevor A Mori, Hania Szajewska, Raanan Shamir, Sibylle Koletzko, Martina Weber, Lawrence J Beilin, Rae-Chi Huang, Berthold Koletzko
Background: Growth patterns of breastfed and formula-fed infants may differ, with formula-fed infants growing more rapidly than breastfed infants into childhood and adulthood.Objectives: Our objectives were to identify growth patterns and investigate early nutritional programming potential on growth patterns at 6 y and on body composition at 20 y.Design: The West Australian Pregnancy Cohort (Raine) Study and 3 European cohort studies (European Childhood Obesity Trial, Norwegian Human Milk Study, and Prevention of Coeliac Disease) that collaborate in the European Union-funded Early Nutrition project combined, harmonized, and pooled data on full breastfeeding, anthropometry, and body composition...
June 28, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28645989/joseph-a-oddis-honored-at-ashp-headquarters-dedication
#5
Kate Traynor
No abstract text is available yet for this article.
July 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28625150/update-on-the-molecular-mechanisms-underlying-the-effect-of-cholecystokinin-and-cholecystokinin-1-receptor-on-the-formation-of-cholesterol-gallstones
#6
Helen H Wang, Piero Portincasa, David Q-H Wang
Cholecystokinin (CCK) is an important neuro-intestinal peptide hormone produced by the enteroendocrine I-cells in the upper part of small intestine. Protein- and fat-enriched food plays an important role in triggering CCK secretion from the intestine. Carbohydrates stimulate only small amounts of CCK release. The CCK-1 receptor (CCK-1R) is largely localized in the gallbladder, sphincter of Oddi, pancreas, small intestine, gastric mucosa, and pyloric sphincter, where it is responsible for CCK to regulate multiple digestive processes including gallbladder contraction, pancreatic secretion, small intestinal transit, and gastric emptying...
June 19, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28622182/reflux-associated-cholecystopathy-analysis-of-76-gallbladders-from-patients-with-supra-oddi-union-of-the-pancreatic-duct-and-common-bile-duct-pancreatobiliary-maljunction-elucidates-a-specific-diagnostic-pattern-of-mucosal-hyperplasia-as-a-prelude-to-carcinoma
#7
Takashi Muraki, Bahar Memis, Michelle D Reid, Takeshi Uehara, Tetsuya Ito, Osamu Hasebe, Shinji Okaniwa, Naoto Horigome, Takeshi Hisa, Pardeep Mittal, Alexa Freedman, Shishir Maithel, Juan M Sarmiento, Alyssa Krasinskas, Jill Koshiol, Volkan Adsay
Pancreaticobiliary maljunction (PBM) is the anomalous union of the main pancreatic duct and common bile duct outside the Oddi-sphincter, allowing the reflux of pancreatic juice to the gallbladder. There is only limited awareness and understanding of the pathologic correlates of this condition, mostly from Japan; this entity is largely unrecognized in the West. In this study, 76 gallbladders from patients with PBM (64 from Japan; 12 from the United States) were analyzed and contrasted with 66 from non-PBM patients...
June 15, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28619255/infant-nutrition-and-maternal-obesity-influence-the-risk-of-non-alcoholic-fatty-liver-disease-in-adolescents
#8
Oyekoya T Ayonrinde, Wendy H Oddy, Leon A Adams, Trevor A Mori, Lawrence J Beilin, Nicholas de Klerk, John K Olynyk
BACKGROUND & AIMS: The pathway to non-alcoholic fatty liver disease (NAFLD) in adolescents may have its origins in adiposity gains, nutrition and sedentary lifestyle established during childhood. There is inadequate knowledge regarding the associations between infant nutrition and subsequent NAFLD. We examined the association of maternal factors and infant nutrition, with the subsequent diagnosis of NAFLD in adolescents. METHODS: Adolescents aged 17years in the Western Australian Pregnancy (Raine) Cohort study had fatty liver assessment using liver ultrasound...
May 22, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28607037/international-comparison-of-emergency-hospital-use-for-infants-data-linkage-cohort-study-in-canada-and-england
#9
Katie Harron, Ruth Gilbert, David Cromwell, Sam Oddie, Astrid Guttmann, Jan van der Meulen
OBJECTIVES: To compare emergency hospital use for infants in Ontario (Canada) and England. METHODS: We conducted a population-based data linkage study in infants born ≥34 weeks' gestation between 2010 and 2013 in Ontario (n=253 930) and England (n=1 361 128). Outcomes within 12 months of postnatal discharge were captured in hospital records. The primary outcome was all-cause unplanned admissions. Secondary outcomes included emergency department (ED) visits, any unplanned hospital contact (either ED or admission) and mortality...
June 12, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28592609/tracking-of-vitamin-d-status-from-childhood-to-early-adulthood-and-its-association-with-peak-bone-mass
#10
Kun Zhu, Wendy H Oddy, Patrick Holt, Wendy Chan She Ping-Delfos, Jenny Mountain, Stephen Lye, Craig Pennell, Prue H Hart, John P Walsh
Background: To our knowledge, there are few longitudinal studies of vitamin D status from childhood to early adulthood, and it is uncertain whether vitamin D predicts peak bone mass in young adults.Objectives: The purpose of this longitudinal study was to evaluate the long-term stability of vitamin D status from ages 6 to 20 y in healthy individuals and to study associations between serum 25-hydroxyvitamin D [25(OH)D] at different developmental stages and bone mass measured at age 20 y.Design: Participants were offspring of the Western Australian Pregnancy Cohort (Raine) study...
June 7, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28582656/non-linear-relationship-between-maternal-work-hours-and-child-body-weight-evidence-from-the-western-australian-pregnancy-cohort-raine-study
#11
Jianghong Li, Plamen Akaliyski, Jakob Schäfer, Garth Kendall, Wendy H Oddy, Fiona Stanley, Lyndall Strazdins
Using longitudinal data from the Western Australia Pregnancy Cohort (Raine) Study and both random-effects and fixed-effects models, this study examined the connection between maternal work hours and child overweight or obesity. Following children in two-parent families from early childhood to early adolescence, multivariate analyses revealed a non-linear and developmentally dynamic relationship. Among preschool children (ages 2 to 5), we found lower likelihood of child overweight and obesity when mothers worked 24 h or less per week, compared to when mothers worked 35 or more hours...
August 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28548201/-morphine-induced-biliary-pain-case-report
#12
Zoltán Berger, Mario Arcos, Fernanda Matamala, Claudia Rojas
Morphine produces contraction of Oddi’s sphincter, which can be severe and of longer duration in some pathological conditions. This exaggerated response can manifest as a colicky biliary pain, frequently accompanied by a dramatic increase in hepatic enzymes. We report a 32 years old female who consulted in the emergency room for severe low abdominal pain of gynecologic origin, which was completely controlled by morphine. However, she presented a sudden epigastric colicky pain irradiating in the back, which persisted for several hours in spite of the repeated administration of analgesics...
March 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28521318/breastfeeding-childhood-asthma-and-allergic-disease
#13
Wendy H Oddy
The worldwide prevalence of childhood asthma has been increasing considerably, and the protection afforded by breastfeeding in its development has been the subject of controversy for more than 80 years. Previous systematic reviews have generally found a protective effect of breastfeeding on allergic outcomes, although many studies have methodological limitations. Although breastfeeding is protective against lower respiratory tract infection during infancy, such protection has not been demonstrated for asthma in all studies...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28511571/brain-injury-and-offending-the-development-and-field-testing-of-a-linkworker-intervention
#14
Sara D S Ramos, Michael Oddy, James Liddement, Deborah Fortescue
Evidence suggests that traumatic brain injury (TBI) is more prevalent amongst offender populations than in the general population, and that it can lead to aggressive behaviour while in custody and impair engagement with offender rehabilitation programmes. The aim of this study was to develop, implement, and evaluate a brain injury Linkworker approach designed to support prisoners who report a significant TBI or multiple mild TBIs. Three clinical case examples are reported to illustrate the conceptual foundations of the approach and to demonstrate the feasibility of the service...
May 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/28511162/improvement-of-the-complex-medical-treatment-for-the-patients-w%C3%B1-th-chronic-biliary-pancreatitis
#15
L S Babinets, K Yu Kytsai, Yu Ya Kotsaba, I M Halabitska, N A Melnyk, I V Semenova, O S Zemlyak
INTRODUCTION: The most common reason of chronic pancreatitis is liver and bile ducts disease: functional disorders, chronic cholecystitis, cholelithiasis and cholecystectomy in medical history. All these changes are associated with the colloidal structure of bile, increased lithogenicity, gallstones formation, Oddi's sphincter dysfunction, dysmotility and inflammation in the bile ducts. THE AIM: to study the effectiveness of using medicine Liveria IC (metadoxine) in standard therapy as well as effect on spectrum of blood serum lipids and structural condition of liver (stiffness) and pancreas in patients with chronic biliary pancreatitis combined with obesity...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28493170/eluxadoline-a-review-in-diarrhoea-predominant-irritable-bowel-syndrome
#16
REVIEW
Gillian M Keating
Eluxadoline (Truberzi(®)) is an orally administered, minimally absorbed agent that acts locally in the gastrointestinal tract as a mixed µ-opioid receptor agonist and δ-opioid receptor antagonist. The randomized, double-blind, placebo-controlled, multinational, phase 3 IBS-3001 and IBS-3002 trials examined the efficacy of eluxadoline in patients with diarrhoea-predominant irritable bowel syndrome (IBS-D). The composite response rate (i.e. the proportion of patients with improvement in both worst abdominal pain and stool consistency on ≥50% of days; primary endpoint), was significantly higher in patients receiving eluxadoline 100 mg twice daily than in those receiving placebo after 12 and 26 weeks' therapy...
June 2017: Drugs
https://www.readbyqxmd.com/read/28489079/trpv1-channels-are-critical-brain-inflammation-detectors-and-neuropathic-pain-biomarkers-in-mice
#17
Maria Cristina Marrone, Annunziato Morabito, Michela Giustizieri, Valerio Chiurchiù, Alessandro Leuti, Marzia Mattioli, Sara Marinelli, Loredana Riganti, Marta Lombardi, Emanuele Murana, Antonio Totaro, Daniele Piomelli, Davide Ragozzino, Sergio Oddi, Mauro Maccarrone, Claudia Verderio, Silvia Marinelli
The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated. Here we report that TRPV1 is highly expressed in microglial cells rather than neurons of the anterior cingulate cortex and other brain areas. We found that stimulation of microglial TRPV1 controls cortical microglia activation per se and indirectly enhances glutamatergic transmission in neurons by promoting extracellular microglial microvesicles shedding...
May 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28488091/outcomes-of-endoscopic-retrograde-cholangiopancreatography-ercp-and-sphincterotomy-for-suspected-sphincter-of-oddi-dysfunction-sod-post-roux-en-y-gastric-bypass
#18
Chin Hong Lim, Cyrus Jahansouz, Martin L Freeman, Daniel B Leslie, Sayeed Ikramuddin, Stuart K Amateau
BACKGROUND: Sphincter of Oddi dysfunction (SOD) is thought to be a cause of chronic abdominal pain post Roux-en-Y gastric bypass, and current practice of performing endoscopic retrograde cholangiopancreatography (ERCP) with or without sphincterotomy is not supported by evidence. In addition to the complexity and risks of the procedure in patients with Roux-en-Y anatomy, the outcomes are uncertain and debatable. We performed a retrospective review and analysis of post-gastric bypass patients who had undergone ERCP with sphincterotomy to determine the effectiveness in patients with suspected SOD...
May 9, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28475816/interleukin-1-blockade-in-heart-failure-with-preserved-ejection-fraction-rationale-and-design-of-the-diastolic-heart-failure-anakinra-response-trial-2-d-hart2
#19
Benjamin W Van Tassell, Leo F Buckley, Salvatore Carbone, Cory R Trankle, Justin M Canada, Dave L Dixon, Nayef Abouzaki, Claudia Oddi-Erdle, Giuseppe Biondi-Zoccai, Ross Arena, Antonio Abbate
Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of confirmed HF cases in the United States. However, there are no highly effective evidence-based treatments currently available for these patients. Inflammation correlates positively with adverse outcomes in HF patients. Interleukin (IL)-1, a prototypical inflammatory cytokine, has been implicated as a driver of diastolic dysfunction in preclinical animal models and a pilot clinical trial. The Diastolic Heart Failure Anakinra Response Trial 2 (D-HART2) is a phase 2, 2:1 randomized, double-blind, placebo-controlled clinical trial that will test the hypothesis that IL-1 blockade with anakinra (recombinant human IL-1 receptor antagonist) improves (1) cardiorespiratory fitness, (2) objective evidence of diastolic dysfunction, and (3) elevated inflammation in patients with HFpEF (http://www...
May 5, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28465786/analysis-of-the-risk-factors-for-severity-in-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-the-indication-of-prophylactic-treatments
#20
Hiroshi Matsubara, Fumihiro Urano, Yuki Kinoshita, Shozo Okamura, Hiroki Kawashima, Hidemi Goto, Yoshiki Hirooka
AIM: To determine the risk factors of severe post endoscopic retrograde cholangiopancreatography pancreatitis (sPEP) and clarify the indication of prophylactic treatments. METHODS: At our hospital, endoscopic retrograde cholangiopancreatography (ERCP) was performed on 1507 patients from May 2012 to December 2015. Of these patients, we enrolled all 121 patients that were diagnosed with post endoscopic retrograde PEP. Fourteen of 121 patients diagnosed as sPEP were analyzed...
April 16, 2017: World Journal of Gastrointestinal Endoscopy
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