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Mood dysregulation disorder

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https://www.readbyqxmd.com/read/28899532/the-association-between-disruptive-mood-dysregulation-disorder-symptoms-and-sleep-problems-in-children-with-and-without-adhd
#1
James G Waxmonsky, Susan D Mayes, Susan L Calhoun, Julio Fernandez-Mendoza, Daniel A Waschbusch, Brianna H Bendixsen, Edward O Bixler
BACKGROUND: Many youth experience persistent irritability and recurrent temper outbursts, conceptualized by DSM-5 as Disruptive Mood Dysregulation Disorder (DMDD). Sleep deprivation impairs emotion regulation which could increase rates of DMDD symptoms, especially in those with preexisting regulatory impairments, as seen with ADHD. However, there has been little examination of the relationship between chronic sleep problems and DMDD symptoms. METHODS: Associations between DMDD symptoms and sleep parameters in children were assessed using parent-report and objective measures of sleep in a general population sample (N = 665) and an ADHD sample (N = 784)...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28892068/dysregulation-of-objectively-assessed-24-hour-motor-activity-patterns-as-a-potential-marker-for-bipolar-i-disorder-results-of-a-community-based-family-study
#2
H Shou, L Cui, I Hickie, D Lameira, F Lamers, J Zhang, C Crainiceanu, V Zipunnikov, K R Merikangas
There has been a growing number of studies that have employed actigraphy to investigate differences in motor activity in mood disorders. In general, these studies have shown that people with bipolar disorders (BPDs) tend to exhibit greater variability and less daytime motor activity than controls. The goal of this study was to examine whether patterns of motor activity differ in euthymic individuals across the full range of mood disorder subtypes (Bipolar I (BPI), Bipolar II (BPII) and major depression (MDD)) compared with unaffected controls in a community-based family study of mood spectrum disorders...
August 22, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28889048/mania-triggered-by-sleep-loss-and-risk-of-postpartum-psychosis-in-women-with-bipolar-disorder
#3
Katie J S Lewis, Arianna Di Florio, Liz Forty, Katherine Gordon-Smith, Amy Perry, Nick Craddock, Lisa Jones, Ian Jones
BACKGROUND: Women with bipolar disorder are at high risk of affective psychoses following childbirth (i.e. "postpartum psychosis", PP) and there is a need to identify which factors underlie this increased risk. Vulnerability to mood dysregulation following sleep loss may influence risk of PP, as childbirth is typified by sleep disruption. We investigated whether a history of mood episodes triggered by sleep loss was associated with PP in women with bipolar disorder (BD). METHODS: Participants were 870 parous women with BD recruited to the Bipolar Disorder Research Network...
August 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28865715/plasma-oxytocin-levels-in-major-depressive-and-bipolar-ii-disorders
#4
Yueh-Ju Lien, Hui Hua Chang, Hsin-Chun Tsai, Yen Kuang Yang, Ru-Band Lu, Po See Chen
Oxytocin may play a role in mood regulation. Research has shown the plasma oxytocin level of patients with bipolar I disorder (BD I) during a manic episode was significantly higher than that of BD I patients of other statuses, and also that of healthy subjects. However, whether or not a difference in the level of oxytocin exists between patients with major depressive disorder (MDD) and those with BD II is unclear. This study aimed to investigate the plasma oxytocin levels in MDD and BD II patients in a depressive episode...
August 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28865369/binge-eating-behaviours-in-bipolar-disorders
#5
Hortense Boulanger, Sarah Tebeka, Chloé Girod, Célia Lloret-Linares, Julie Meheust, Jan Scott, Sébastien Guillaume, Philippe Courtet, Frank Bellivier, Marine Delavest
BACKGROUND: Recent research, especially from the USA, suggests that comorbid binge eating (BE) behaviour and BE disorder are frequent in individuals with Bipolar Disorder (BD). Although basic clinical associations between BD and BE have been investigated, less is known about psychological or temperamental dimensions and qualitative aspects of eating habits. In a French cohort of patients with BD, we investigated the prevalence of BE behaviour and any associations with illness characteristics, anxiety, impulsivity, emotional regulation and eating habits...
August 30, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28837827/pharmacotherapy-of-emotional-dysregulation-in-adults-with-adhd-a-systematic-review-and-meta-analysis
#6
REVIEW
Francesca Lenzi, Samuele Cortese, Joseph Harris, Gabriele Masi
Emotional dysregulation (ED) is a dysfunction in modifying an emotional state in an adaptive and goal oriented way, with excitability, ease anger, and mood lability. It is present in up to 70% of adults with ADHD, regardless of other comorbidities, and substantially worsens the psychosocial outcomes of the disorder. Besides fronto-parietal circuits mediating top-down control, brain regions involved in bottom-up processes (e.g., amygdala, orbitofrontal cortex, and ventral striatum) are implicated in ED. We performed a systematic review/meta-analysis of double-blind randomized controlled trials of ADHD medications to assess their effects on ED in adults with ADHD...
August 25, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28820053/neurobiological-mechanisms-of-stress-resilience-and-implications-for-the-aged-population
#7
Charlène Faye, Josephine C Mcgowan, Christine A Denny, Denis J David
Stress is a common reaction to an environmental adversity, but a dysregulation of the stress response can lead to psychiatric illnesses such as major depressive disorder (MDD), post-traumatic stress disorder (PTSD), and anxiety disorders. Yet, not all individuals exposed to stress will develop psychiatric disorders; those with enhanced stress resilience mechanisms have the ability to adapt successfully to stress without developing persistent psychopathology. Notably, the potential to enhance stress resilience in at-risk populations may prevent the onset of stress-induced psychiatric disorders...
August 17, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28817956/the-role-of-intrinsic-brain-functional-connectivity-in-vulnerability-and-resilience-to-bipolar-disorder
#8
Gaelle E Doucet, Danielle S Bassett, Nailin Yao, David C Glahn, Sophia Frangou
OBJECTIVE: Bipolar disorder is a heritable disorder characterized by mood dysregulation associated with brain functional dysconnectivity. Previous research has focused on the detection of risk- and disease-associated dysconnectivity in individuals with bipolar disorder and their first-degree relatives. The present study seeks to identify adaptive brain connectivity features associated with resilience, defined here as avoidance of illness or delayed illness onset in unaffected siblings of patients with bipolar disorder...
August 18, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28800512/metabotropic-glutamate-receptors-as-emerging-research-targets-in-bipolar-disorder
#9
REVIEW
Caren J Blacker, Charles P Lewis, Mark A Frye, Marin Veldic
Glutamatergic dysregulation is implicated in the neuropathology of bipolar disorder (BD). There is increasing interest in investigating the role of metabotropic glutamate receptors (mGluRs) in BD and as a target for treatment intervention. Bipolar mGluR studies (published January 1992-April 2016) were identified via PubMed, Embase, Web of Science, and Scopus. Full-text screening, data extraction, and quality appraisal were conducted in duplicate, with strict inclusion and exclusion criteria. The initial literature search for mGluRs in BD, including non-bipolar mood disorders and primary psychotic disorders, identified 1544 articles...
July 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28768369/recent-developments-in-understanding-the-role-of-the-gut-microbiota-in-brain-health-and-disease
#10
REVIEW
Eoin Sherwin, Timothy G Dinan, John F Cryan
There is a growing appreciation of the role of the gut microbiota in all aspects of health and disease, including brain health. Indeed, roles for the bacterial commensals in various psychiatric and neurological conditions, such as depression, autism, stroke, Parkinson's disease, and Alzheimer's disease, are emerging. Microbiota dysregulation has been documented in all of these conditions or in animal models thereof. Moreover, depletion or modulation of the gut microbiota can affect the severity of the central pathology or behavioral deficits observed in a variety of brain disorders...
August 2, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28738353/inflammation-effects-on-glutamate-as-a-pathway-to-neuroprogression-in-mood-disorders
#11
Ebrahim Haroon, Andrew H Miller
Neuroprogression is a term used to describe worsening psychopathology, poor treatment response, and declining cognitive and functional outcomes among patients with chronic mental disorders. Chronic inflammatory activation and glutamate-mediated excitotoxicity are two key etiological factors implicated in the development of neuroprogression. In this chapter, we hypothesize that the association between chronic inflammatory activation, neuroprogression, and glutamate dysregulation might be mediated by glial dysfunction...
2017: Modern Trends in Pharmacopsychiatry
https://www.readbyqxmd.com/read/28730183/aberrant-cerebellar-connectivity-in-bipolar-disorder-with-psychosis
#12
Ann K Shinn, Youkyung S Roh, Caitlin T Ravichandran, Justin T Baker, Dost Öngür, Bruce M Cohen
BACKGROUND: The cerebellum, which modulates affect and cognition in addition to motor functions, may contribute substantially to the pathophysiology of mood and psychotic disorders, such as bipolar disorder. A growing literature points to cerebellar abnormalities in bipolar disorder. However, no studies have investigated the topographic representations of resting state cerebellar networks in bipolar disorder, specifically their functional connectivity to cerebral cortical networks. METHODS: Using a well-defined cerebral cortical parcellation scheme as functional connectivity seeds, we compared ten cerebellar resting state networks in 49 patients with bipolar disorder and a lifetime history of psychotic features and 55 healthy control participants matched for age, sex, and image signal-to-noise ratio...
July 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28702350/reading-related-white-matter-structures-in-adolescents-are-influenced-more-by-dysregulation-of-emotion-than-behavior
#13
Tzipi Horowitz-Kraus, Scott K Holland, Amelia L Versace, Michele A Bertocci, Genna Bebko, Jorge R C Almeida, Susan B Perlman, Michael J Travis, Mary Kay Gill, Lisa Bonar, Claudiu Schirda, Jeffrey L Sunshine, Boris Birmaher, Gerry Taylor, Vaibhav A Diwadkar, Sarah M Horwitz, David Axelson, Thomas Frazier, Eugene L Arnold, Mary A Fristad, Eric A Youngstrom, Robert L Findling, Mary L Phillips
Mood disorders and behavioral are broad psychiatric diagnostic categories that have different symptoms and neurobiological mechanisms, but share some neurocognitive similarities, one of which is an elevated risk for reading deficit. Our aim was to determine the influence of mood versus behavioral dysregulation on reading ability and neural correlates supporting these skills in youth, using diffusion tensor imaging in 11- to 17-year-old children and youths with mood disorders or behavioral disorders and age-matched healthy controls...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28683115/using-machine-learning-and-surface-reconstruction-to-accurately-differentiate-different-trajectories-of-mood-and-energy-dysregulation-in-youth
#14
Amelia Versace, Vinod Sharma, Michele A Bertocci, Genna Bebko, Satish Iyengar, Amanda Dwojak, Lisa Bonar, Susan B Perlman, Claudiu Schirda, Michael Travis, Mary Kay Gill, Vaibhav A Diwadkar, Jeffrey L Sunshine, Scott K Holland, Robert A Kowatch, Boris Birmaher, David Axelson, Thomas W Frazier, L Eugene Arnold, Mary A Fristad, Eric A Youngstrom, Sarah M Horwitz, Robert L Findling, Mary L Phillips
Difficulty regulating positive mood and energy is a feature that cuts across different pediatric psychiatric disorders. Yet, little is known regarding the neural mechanisms underlying different developmental trajectories of positive mood and energy regulation in youth. Recent studies indicate that machine learning techniques can help elucidate the role of neuroimaging measures in classifying individual subjects by specific symptom trajectory. Cortical thickness measures were extracted in sixty-eight anatomical regions covering the entire brain in 115 participants from the Longitudinal Assessment of Manic Symptoms (LAMS) study and 31 healthy comparison youth (12...
2017: PloS One
https://www.readbyqxmd.com/read/28667510/a-randomized-controlled-trial-of-ganaxolone-in-posttraumatic-stress-disorder
#15
Ann M Rasmusson, Christine E Marx, Sonia Jain, Gail M Farfel, Julia Tsai, Xiaoying Sun, Thomas D Geracioti, Mark B Hamner, James Lohr, Richard Rosse, Lanier Summerall, Jennifer C Naylor, Cristine Cusin, Ariel J Lang, Rema Raman, Murray B Stein
Preclinical and clinical research supports a role for neuroactive steroids in the pathophysiology of posttraumatic stress disorder (PTSD). We investigated ganaxolone (a synthetic 3β-methylated derivative of allopregnanolone, a GABAergic neuroactive steroid) for treatment of PTSD in a proof-of-concept, multisite, double-blind, placebo-controlled trial. Veteran and non-veteran participants (n = 112) were randomized to ganaxolone or placebo at biweekly escalating doses of 200, 400, and 600 mg twice daily for 6 weeks...
August 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28653665/circulating-endocannabinoids-from-whence-do-they-come-and-where-are-they-going
#16
Cecilia J Hillard
The goal of this review is to summarize studies in which concentrations of circulating endocannabinoids in humans have been examined in relationship to physiological measurements and pathological status. The roles of endocannabinoids in the regulation of energy intake and storage have been well studied and the data obtained consistently support the hypothesis that endocannabinoid signaling is associated with increased consumption and storage of energy. Physical exercise mobilizes endocannabinoids, which could contribute to refilling of energy stores and also to the analgesic and mood-elevating effects of exercise...
June 27, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28649671/early-life-stress-mood-and-anxiety-disorders
#17
Shariful A Syed, Charles B Nemeroff
Early life stress has been shown to exert profound short- and long-term effects on human physiology both in the central nervous system and peripherally. Early life stress has demonstrated clear association with many psychiatric disorders including major depression, posttraumatic stress disorder, and bipolar disorder. The Diagnostic and Statistics Manuel of Mental Disorders (DSM) diagnostic categorical system has served as a necessary framework for clinical service, delivery, and research, however has not been completely matching the neurobiological research perspective...
February 2017: Chronic stress
https://www.readbyqxmd.com/read/28638203/the-history-diagnosis-and-treatment-of-disruptive-mood-dysregulation-disorder
#18
Jun Chen, Zuowei Wang, Yiru Fang
Disruptive mood dysregulation disorder was newly included as a diagnostic category in Diagnostic and statistical manual of mental disorders fifth edition (DSM-5), but the knowledge about it in the clinical practice field is still limited. Therefore, the aim of the present article is to introduce this diagnostic category's history, key points of diagnosis, treatment and its impact on clinical practice for clinical reference.
October 25, 2016: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/28595749/negative-emotional-verbal-memory-biases-in-mild-cognitive-impairment-and-late-onset-depression
#19
Linda Mah, Nicole D Anderson, Nicolaas Paul L G Verhoeff, Bruce G Pollock
OBJECTIVE: Early and preferential targeting of limbic structures by Alzheimer disease (AD)-related pathology suggests emotion dysregulation may serve as a marker of AD risk. We studied emotional verbal memory in two groups at risk for AD, amnestic mild cognitive impairment (aMCI) and late-onset depression (LOD), to test the hypothesis that aMCI and LOD would be characterized by a negative bias in emotional memory, whereas cognitively normal (CN) adults would show the "positivity effect" associated with healthy aging...
October 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28588894/aetiological-pathways-to-borderline-personality-disorder-symptoms-in-early-adolescence-childhood-dysregulated-behaviour-maladaptive-parenting-and-bully-victimisation
#20
Catherine Winsper, James Hall, Vicky Y Strauss, Dieter Wolke
BACKGROUND: Developmental theories for the aetiology of Borderline Personality Disorder (BPD) suggest that both individual features (e.g., childhood dysregulated behaviour) and negative environmental experiences (e.g., maladaptive parenting, peer victimisation) may lead to the development of BPD symptoms during adolescence. Few prospective studies have examined potential aetiological pathways involving these two factors. METHOD: We addressed this gap in the literature using data from the Avon Longitudinal Study of Parents and Children (ALSPAC)...
2017: Borderline Personality Disorder and Emotion Dysregulation
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