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Mood dysregulation disorder

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https://www.readbyqxmd.com/read/29753187/dsm-5-intermittent-explosive-disorder-relationship-with-disruptive-mood-dysregulation-disorder
#1
Emil F Coccaro
OBJECTIVE: This study was designed to estimate how many adults with DSM-5 Intermittent Explosive Disorder (IED) would also meet diagnostic criteria for Disruptive Mood Dysregulation Disorder (DMDD). This was done by examining how many individuals with IED would meet the DMDD criterion of being persistently angry in between impulsive aggressive outbursts. METHODS: The first one-hundred study participants diagnosed with DSM-5 IED in our clinical research program were included in this study...
April 30, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29747703/dark-matters-effects-of-light-at-night-on-metabolism
#2
Randy J Nelson, Souhad Chbeir
Life on earth has evolved during the past several billion years under relatively bright days and dark night conditions. The wide-spread adoption of electric lights during the past century exposed animals, both human and non-human, to significant light at night for the first time in their evolutionary history. Endogenous circadian clocks depend on light to entrain to the external daily environment and seasonal rhythms depend on clear nightly melatonin signals to assess time of year. Thus, light at night can derange temporal adaptations...
May 11, 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29730721/comparing-the-dsm-5-construct-of-disruptive-mood-dysregulation-disorder-and-icd-10-mixed-disorder-of-emotion-and-conduct-in-the-uk-longitudinal-assessment-of-manic-symptoms-uk-lams-study
#3
I Sagar-Ouriaghli, G Milavic, R Barton, N Heaney, F Fiori, K Lievesley, J Singh, Paramala Santosh
It is important to understand new diagnostic entities in classifications of psychopathology such as the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) (code F34.8) construct of Disruptive Mood Dysregulation Disorder (DMDD) and to compare it with possible equivalent disorders in other classificatory systems such as the International Classification of Diseases-10 (ICD-10), which has a category that superficially appears similar, that is, Mixed Disorder of Emotion and Conduct (MDEC) (code F92)...
May 5, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29725312/psychometric-properties-of-the-difficulties-in-emotion-regulation-scale-ders-and-its-short-forms-in-adults-with-emotional-disorders
#4
Lauren S Hallion, Shari A Steinman, David F Tolin, Gretchen J Diefenbach
Objective: The Difficulties in Emotion Regulation Scale (DERS) is a widely used self-report measure of subjective emotion ability, as defined by a prominent clinically derived model of emotion regulation (Gratz and Roemer, 2004). Although the DERS is often used in treatment and research settings for adults with emotional (i.e., anxiety, mood, obsessive-compulsive, or trauma-related) disorders, its psychometric properties are not well-characterized in this population. Method: We examined the psychometric properties of the DERS and three popular short forms (DERS-16; DERS-18; and DERS-SF) in a large ( N = 427) sample of treatment-seeking adults with one or more DSM-5 emotional disorders...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29723540/tnf%C3%AE-dependent-anhedonia-and-upregulation-of-hippocampal-serotonin-transporter-activity-in-a-mouse-model-of-collagen-induced-arthritis
#5
Eric Brown, Conor J Mc Veigh, Leilani Santos, Martina Gogarty, Heidi Kaastrup Müller, Betina Elfving, David J Brayden, Jana Haase
The serotonin transporter (SERT) facilitates high affinity reuptake of 5-HT from the extracellular fluid and dysregulation of transporter function has been implicated in a range of mood disorders including depression. Recent studies have linked immune system activation to depression as well as to altered serotonin transporter activity. Advancing previous studies, which have mainly focussed on acute effects of immune system activation, in this study we used collagen-induced arthritis (CIA) in mice as a model of chronic inflammatory disease, to investigate the effect of prolonged inflammation on brain SERT function and behaviour...
April 30, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29719093/interpersonal-psychotherapy-for-mood-and-behavior-dysregulation-pilot-randomized-trial
#6
Leslie Miller, Stefanie A Hlastala, Laura Mufson, Ellen Leibenluft, Gayane Yenokyan, Mark Riddle
BACKGROUND: Youth with chronic irritability and excessive reactivity, diagnosed as disruptive mood dysregulation disorder (DMDD), have social impairment in multiple settings (i.e., peers, school, and home). This paper presents a pilot randomized trial assessing the feasibility, acceptability, and preliminary efficacy of interpersonal psychotherapy (IPT) for mood and behavior dysregulation (IPT-MBD), an adapted version of IPT for depressed adolescents. IPT-MBD focuses on decreasing outbursts and irritability and improving interpersonal interactions...
May 2, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29708895/offspring-of-parents-with-mood-disorders-time-for-more-transgenerational-research-screening-and-preventive-intervention-for-this-high-risk-population
#7
Dominique Maciejewski, Manon Hillegers, Brenda Penninx
PURPOSE OF REVIEW: Offspring of parents with mood disorders (major depressive and bipolar disorder) are at increased risk for developing mood disorders. In this review, an overview regarding the intergenerational transmission of mood disorders, screening, and preventive intervention is given for this vulnerable group. RECENT FINDINGS: Offspring of parents with depression have a 40% chance of developing a depression, whereas offspring of parents with bipolar disorder have a 10% chance of developing a bipolar disorder by adulthood...
April 26, 2018: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29708762/improvements-in-irritability-with-open-label-methylphenidate-treatment-in-youth-with-comorbid-attention-deficit-hyperactivity-disorder-and-disruptive-mood-dysregulation-disorder
#8
Drew E Winters, Sadaaki Fukui, Ellen Leibenluft, Leslie A Hulvershorn
OBJECTIVE: The purpose of this open-label study was to examine the effects of long-acting methylphenidate (MPH) treatment on irritability and related emotional symptoms associated with disruptive mood dysregulation disorder (DMDD) in youth with comorbid attention-deficit/hyperactivity disorder (ADHD). METHODS: The sample included 22 medication-free male and female subjects (ages 9-15) who met criteria for both DMDD and ADHD. Participants underwent a 4-week trial of long-acting MPH treatment (Concerta® ), with weekly dosing increases until a therapeutic dose was reached...
April 30, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29704965/changes-in-problematic-anger-shame-and-disgust-in-anxious-and-depressed-adults-undergoing-treatment-for-emotion-dysregulation
#9
Andrada D Neacsiu, Joscelyn Rompogren, Jeremy W Eberle, Kibby McMahon
Emotion dysregulation, the pervasive difficulty managing negative emotions, is a core problem across mood and anxiety disorders. Anger, shame, and disgust are particularly problematic emotions, impacting both disorder severity and treatment outcome. We previously found that a 16-week dialectical behavior therapy skills training group (DBT-ST) was superior to an activities-based support group (ASG) in decreasing emotion dysregulation in 44 adults with high emotion dysregulation who met diagnostic criteria for an anxiety or depressive disorder...
May 2018: Behavior Therapy
https://www.readbyqxmd.com/read/29696773/complex-phenotype-of-dyskeratosis-congenita-and-mood-dysregulation-with-novel-homozygous-rtel1-and-tph1-variants
#10
Rachel A Ungar, Neelam Giri, Maryland Pao, Payal P Khincha, Weiyin Zhou, Blanche P Alter, Sharon A Savage
Dyskeratosis congenita (DC) is an inherited bone marrow failure syndrome caused by germline mutations in telomere biology genes. Patients have extremely short telomeres for their age and a complex phenotype including oral leukoplakia, abnormal skin pigmentation, and dysplastic nails in addition to bone marrow failure, pulmonary fibrosis, stenosis of the esophagus, lacrimal ducts and urethra, developmental anomalies, and high risk of cancer. We evaluated a patient with features of DC, mood dysregulation, diabetes, and lack of pubertal development...
April 25, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29679070/the-role-of-adult-hippocampal-neurogenesis-in-brain-health-and-disease
#11
REVIEW
Tomohisa Toda, Sarah L Parylak, Sara B Linker, Fred H Gage
Adult neurogenesis in the dentate gyrus of the hippocampus is highly regulated by a number of environmental and cell-intrinsic factors to adapt to environmental changes. Accumulating evidence suggests that adult-born neurons may play distinct physiological roles in hippocampus-dependent functions, such as memory encoding and mood regulation. In addition, several brain diseases, such as neurological diseases and mood disorders, have deleterious effects on adult hippocampal neurogenesis, and some symptoms of those diseases can be partially explained by the dysregulation of adult hippocampal neurogenesis...
April 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29667700/irritability-and-parenting-styles-in-adolescents-with-attention-deficit-hyperactivity-disorder-a-controlled-study
#12
Halit Necmi Uçar, Ayşe Pınar Vural
Attention-deficit/hyperactivity disorder (ADHD) affects functioning of the family, decreasing interactions and loyalty and increasing conflict between adolescents with ADHD and their families. Irritable mood and difficulties with emotional dysregulation are common in children with ADHD. The objective of the current study was to assess levels of irritability in adolescents with ADHD using self- and parent-report scales, and investigate the relationship between irritability levels and parental attitudes. A total of 47 adolescents with ADHD and 39 adolescents with typical development participated in the current study...
April 17, 2018: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29651257/mindfulness-based-interventions-for-the-treatment-of-substance-and-behavioral-addictions-a-systematic-review
#13
Marta Sancho, Marta De Gracia, Rita C Rodríguez, Núria Mallorquí-Bagué, Jéssica Sánchez-González, Joan Trujols, Isabel Sánchez, Susana Jiménez-Murcia, Jose M Menchón
Background: Emotion (dys)regulation as well as the interventions for improving these difficulties are receiving a growing attention in the literature. The aim of the present paper was to conduct a systematic review about the efficacy of mindfulness-based interventions (MBIs) in both substance and behavioral addictions (BAs). Method: A literature search was conducted using Cochrane, PubMed, and Web of Science. Fifty-four randomized controlled trials published in English since 2009 to April 2017 were included into a narrative synthesis...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29642911/gnrh-dysregulation-in-polycystic-ovarian-syndrome-pcos-is-a-manifestation-of-an-altered-neurotransmitter-profile
#14
Nirja Chaudhari, Mitali Dawalbhakta, Laxmipriya Nampoothiri
BACKGROUND: GnRH is the master molecule of reproduction that is influenced by several intrinsic and extrinsic factors such as neurotransmitters and neuropeptides. Any alteration in these regulatory loops may result in reproductive-endocrine dysfunction such as the polycystic ovarian syndrome (PCOS). Although low dopaminergic tone has been associated with PCOS, the role of neurotransmitters in PCOS remains unknown. The present study was therefore aimed at understanding the status of GnRH regulatory neurotransmitters to decipher the neuroendocrine pathology in PCOS...
April 11, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29627697/are-the-components-of-social-reciprocity-transdiagnostic-across-pediatric-neurodevelopmental-disorders-evidence-for-common-and-disorder-specific-social-impairments
#15
Alexandra Sturm, Michelle Rozenman, Susanna Chang, James J McGough, James T McCracken, John C Piacentini
Deficits in social communication are a core feature of autism spectrum disorder (ASD), yet significant social problems have been observed in youth with many neurodevelopmental disorders. In this preliminary investigation, we aimed to explore whether domains of social reciprocity (i.e., social communication, social cognition, social awareness, social motivation, and restricted and repetitive behaviors) represent transdiagnostic traits. These domains were compared across youth ages 7-17 with obsessive-compulsive disorder (OCD; N = 32), tic disorders (TD; N = 20), severe mood dysregulation (N = 33) and autism spectrum disorder (N = 35)...
March 29, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29625429/a-latent-variable-approach-to-differentiating-neural-mechanisms-of-irritability-and-anxiety-in-youth
#16
Katharina Kircanski, Lauren K White, Wan-Ling Tseng, Jillian Lee Wiggins, Heather R Frank, Stefanie Sequeira, Susan Zhang, Rany Abend, Kenneth E Towbin, Argyris Stringaris, Daniel S Pine, Ellen Leibenluft, Melissa A Brotman
Importance: Comorbidity is ubiquitous in psychiatry, but it is unclear how to differentiate neural mechanisms of co-occurring symptoms. Pediatric irritability and anxiety symptoms are prevalent and frequently co-occur. Threat orienting is pertinent to both phenotypes and is an ideal context in which to examine their unique and common neural mechanisms. Objectives: To decompose the unique and shared variances of pediatric irritability and anxiety symptoms and to determine neural correlates of these differentiated phenotypes during threat orienting...
April 6, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29624671/practitioner-review-emotional-dysregulation-in-attention-deficit-hyperactivity-disorder-implications-for-clinical-recognition-and-intervention
#17
REVIEW
Stephen V Faraone, Anthony L Rostain, Joseph Blader, Betsy Busch, Ann C Childress, Daniel F Connor, Jeffrey H Newcorn
BACKGROUND: Because emotional symptoms are common in attention-deficit/hyperactivity disorder (ADHD) patients and associate with much morbidity, some consider it to be a core feature rather than an associated trait. Others argue that emotional symptoms are too nonspecific for use as diagnostic criteria. This debate has been difficult to resolve due, in part, to the many terms used to describe emotional symptoms in ADHD and to concerns about overlap with mood disorders. METHODS: We sought to clarify the nature of emotional symptoms in ADHD by reviewing conceptual and measurement issues and by examining the evidence base regarding specificity of such symptoms for ADHD...
April 6, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29615850/interplay-between-the-gut-brain-axis-obesity-and-cognitive-function
#18
REVIEW
Ana Agustí, Maria P García-Pardo, Inmaculada López-Almela, Isabel Campillo, Michael Maes, Marina Romaní-Pérez, Yolanda Sanz
Obesity continues to be one of the major public health problems due to its high prevalence and co-morbidities. Common co-morbidities not only include cardiometabolic disorders but also mood and cognitive disorders. Obese subjects often show deficits in memory, learning and executive functions compared to normal weight subjects. Epidemiological studies also indicate that obesity is associated with a higher risk of developing depression and anxiety, and vice versa . These associations between pathologies that presumably have different etiologies suggest shared pathological mechanisms...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29614774/the-brain-intestinal-mucosa-appendix-microbiome-brain-loop
#19
Luis Vitetta, Gemma Vitetta, Sean Hall
The brain and the gut are connected from early fetal life. The mother's exposure to microbial molecules is thought to exert in utero developmental effects on the fetus. These effects could importantly underpin the groundwork for subsequent pathophysiological mechanisms for achieving immunological tolerance and metabolic equilibrium post birth, events that continue through to 3-4 years of age. Furthermore, it is understood that the microbiome promotes cues that instruct the neonate's mucosal tissues and skin in the language of molecular and cellular biology...
April 1, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29607445/a-review-on-the-general-stability-of-mood-disorder-diagnoses-along-the-lifetime
#20
REVIEW
Diego de la Vega, Ana Piña, Francisco J Peralta, Sam A Kelly, Lucas Giner
PURPOSE OF REVIEW: The purpose of this review is to review the most recent literature regarding diagnostic stability of mood disorders, focusing on epidemiological, clinical-psychopathological, and neurobiological data for unipolar and bipolar affective disorders. RECENT FINDINGS: Unipolar depression follows a chronic course in at least half of all cases and presents a considerable diagnostic stability across all age ranges. Studies using latent class analysis are allowing improved profiling of depressive subtypes and assessment of their prevalence...
April 2, 2018: Current Psychiatry Reports
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