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https://www.readbyqxmd.com/read/29783266/multiorgan-failure-syndrome-in-newborns-role-of-social-and-anatomico-functional-features-literature-review
#1
Dmytro A Skurupii, Evgeniy G Sonnyk, Vitaliy M Sizonenko
Protection of maternal health as well as protection of fetal and newborn health is a strategic objective in all countries. It ensures the formation of healthy generation as the basis of gene pool preservation and further development of the nation. It is known that the progress of critical conditions in newborns is different from classical concepts. Аnatomicofunctional features of the newborns (especially premature newborns), the effect of prenatal pathological factors are provocative and background factors of the multiorgan failure syndrome begining in these patients, which probably affects frequency of appearance of this syndrome, the mechanisms of development, clinical manifestations, the final of the disease and makes doctors to consider newborns in critical conditions as high-risk group for multiorgan failure syndrome appearance...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783163/maternal-hypothalamus-pituitary-adrenal-hpa-system-activity-and-stress-during-pregnancy-effects-on-gestational-age-and-infant-s-anthropometric-measures-at-birth
#2
Maria Gilles, Henrike Otto, Isabell A C Wolf, Barbara Scharnholz, Verena Peus, Michael Schredl, Marc W Sütterlin, Stephanie H Witt, Marcella Rietschel, Manfred Laucht, Michael Deuschle
BACKGROUND: Prenatal maternal stress might be a risk for the developing fetus and may have long-lasting effects on child and adult vulnerability to somatic and psychiatric disease. Over-exposure of the unborn to excess glucocorticoids and subsequent alteration of fetal development is hypothesized to be one of the key mechanisms linking prenatal stress with negative child outcome. METHODS: In this prospective longitudinal study, mothers-to-be (n = 405) in late pregnancy (36...
April 22, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29782826/sheets-of-human-retinal-progenitor-transplants-improve-vision-in-rats-with-severe-retinal-degeneration
#3
Bin Lin, Bryce T McLelland, Anuradha Mathur, Robert B Aramant, Magdalene J Seiler
Loss of photoreceptors and other retinal cells is a common endpoint in retinal degenerate (RD) diseases that cause blindness. Retinal transplantation is a potential therapy to replace damaged retinal cells and improve vision. In this study, we examined the development of human fetal retinal sheets with or without their retinal pigment epithelium (RPE) transplanted to immunodeficient retinal degenerate rho S334ter-3 rats. Sheets were dissected from fetal human eyes (11-15.7 weeks gestation) and then transplanted to the subretinal space of 24-31 d old RD nude rats...
May 18, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29781990/fetal-mouse-cardiovascular-imaging-using-a-high-frequency-ultrasound-30-45mhz-system
#4
Marlin Touma
Congenital heart defects (CHDs) are the most common cause of childhood morbidity and early mortality. Prenatal detection of the underlying molecular mechanisms of CHDs is crucial for inventing new preventive and therapeutic strategies. Mutant mouse models are powerful tools to discover new mechanisms and environmental stress modifiers that drive cardiac development and their potential alteration in CHDs. However, efforts to establish the causality of these putative contributors have been limited to histological and molecular studies in non-survival animal experiments, in which monitoring the key physiological and hemodynamic parameters is often absent...
May 5, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781742/early-prenatal-diagnosis-of-blakes-pouch-cyst-by-2d-3d-ultrasound-with-cristal-and-realistic-vue-application
#5
Gabriele Tonni, Gianpaolo Grisolia, Paolo Zampriolo, Edward Araujo Júnior, Rodrigo Ruano
INTRODUCTION: Blake's pouch cyst (BPC) represents an abnormal development of the posterior membranous area of the fetal brain. MATERIAL AND METHODS: Two- and three-dimensional ultrasound with Cristal and Realistic Vue were used to characterized the early prenatal diagnosis. RESULTS: At 9 weeks and 5 days a ballooning in the posterior fossa and resulting in an enlarged intracranial translucency (IT) was detected by 3D ultrasound using Cristal Vue in "inversion" mode and Cristal plus Realistic Vue...
May 21, 2018: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/29779877/developmental-upregulation-of-ephrin-b1-silences-sema3c-neuropilin-1-signaling-during-post-crossing-navigation-of-corpus-callosum-axons
#6
Erik Mire, Mélanie Hocine, Elsa Bazellières, Thomas Jungas, Alice Davy, Sophie Chauvet, Fanny Mann
The corpus callosum is the largest commissure in the brain, whose main function is to ensure communication between homotopic regions of the cerebral cortex. During fetal development, corpus callosum axons (CCAs) grow toward and across the brain midline and then away on the contralateral hemisphere to their targets. A particular feature of this circuit, which raises a key developmental question, is that the outgoing trajectory of post-crossing CCAs is mirror-symmetric with the incoming trajectory of pre-crossing axons...
May 10, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29778942/transcriptomic-and-methylomic-analysis-reveal-the-toxicological-effect-of-2-3-7-8-tetrachlorodibenzodioxin-on-human-embryonic-stem-cell
#7
Keng Po Lai, Jing Woei Li, Ting Fung Chan, Andy Chen, Cherie Yin Lau Lee, William Shu Biu Yeung, Chris Kong Chu Wong
Cumulating epidemiological studies demonstrated that environmental exposure to endocrine disrupting chemicals (EDCs) during the early stages of fetal development is associated with the increase in disease susceptibility in later life. The fetal developmental plasticity is considered as a protective mechanism against an undesirable prenatal environment. Dioxin is one of the environmental contaminants and is considered a diabetogenic factor. Experimental animal and human epidemiological studies have revealed that dioxin exposure was associated with insulin resistance and altered beta cell function...
May 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29778808/maternal-treatment-with-a-placental-targeted-antioxidant-mitoq-impacts-offspring-cardiovascular-function-in-a-rat-model-of-prenatal-hypoxia
#8
Mais M Aljunaidy, Jude S Morton, Raven Kirschenman, Tom Phillips, C Patrick Case, Christy-Lynn M Cooke, Sandra T Davidge
Intrauterine growth restriction, a common consequence of prenatal hypoxia, is a leading cause of fetal morbidity and mortality with a significant impact on population health. Hypoxia may increase placental oxidative stress and lead to an abnormal release of placental-derived factors, which are emerging as potential contributors to developmental programming. Nanoparticle-linked drugs are emerging as a novel method to deliver therapeutics targeted to the placenta and avoid risking direct exposure to the fetus...
May 17, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29777883/atypical-presentation-of-giant-aneurysm-in-a-pediatric-patient-with-duane-syndrome
#9
Chao-Hung Kuo, Lynn B McGrath, Joseph A Carnevale, Neena I Marupudi, Jeffery G Ojemann, Richard G Ellenbogen, Anthony C Wang
BACKGROUND: Duane syndrome is a congenital eye movement disorder characterized by congenital malformation of the abducens nucleus. Thrombogenic conditions during development may lead to vascular anomalies in Duane syndrome, however, the presence of a giant aneurysm in this patient population is a rarely documented phenomenon. CASE DESCRIPTION: We reported a case of a large cerebral aneurysm in a pediatric patient with Duane syndrome, and performed a review of the literatures to identify other potential cases and associations...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29775869/mathematics-intervention-for-children-with-fetal-alcohol-spectrum-disorder-a-replication-and-extension-of-the-math-interactive-learning-experience-mile-program
#10
Katrina Kully-Martens, Jacqueline Pei, Julie Kable, Claire D Coles, Gail Andrew, Carmen Rasmussen
BACKGROUND: Individuals with fetal alcohol spectrum disorders (FASD) experience deficits in behavior, cognition, and academic functioning resulting from prenatal alcohol exposure (PAE). Although receiving intervention for developmental disabilities is a strong protective factor against negative outcomes in FASD, intervention research in this population is in its infancy. AIMS: The purpose of this study was to replicate and extend a mathematics intervention, the Math Interactive Learning Experience (MILE) program, which was developed in the USA specifically for children with FASD...
May 15, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29774552/no-sympathy-for-the-hypoxic-the-role-of-fetal-oxygenation-in-autonomic-dysfunction
#11
Jonathan D Hoang, Marmar Vaseghi
Uteroplacental insufficiency, defined as the failure of the placenta to adequately supply nutrients to the developing fetus, can result from insufficient blood flow to the placenta, and thereby deficient fetal oxygenation. This article is protected by copyright. All rights reserved.
May 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29774535/physiology-and-molecular-biology-of-barrier-mechanisms-in-the-fetal-and-neonatal-brain
#12
Norman R Saunders, Katarzyna M Dziegielewska, Kjeld Møllgård, Mark D Habgood
Properties of the local internal environment of the adult brain are tightly controlled providing a stable milieu essential for its normal function. The mechanisms involved in this complex control are structural, molecular and physiological (influx and efflux transporters) frequently referred to as the "blood-brain barrier". These mechanisms include regulation of ion levels in brain interstitial fluid essential for normal neuronal function, supply of nutrients, removal of metabolic products and prevention of entry or elimination of toxic agents...
May 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29774380/-thyroid-and-pregnancy
#13
REVIEW
K A Iwen, H Lehnert
During pregnancy thyroid hormones have profound effects on embryonal/fetal development and maternal health. Therefore, thyroid gland disorders should be immediately diagnosed and adequately treated. Pregnancy-specific physiological alterations during pregnancy cause changes in the reference interval for thyroid-stimulating hormone levels and trimester-specific thresholds must be taken into account. This article summarizes the most important diagnostic and therapeutic aspects before, during and after pregnancy...
May 17, 2018: Der Internist
https://www.readbyqxmd.com/read/29774074/placenta-specific-drug-delivery-by-trophoblast-targeted-nanoparticles-in-mice
#14
Baozhen Zhang, Lunbo Tan, Yan Yu, Baobei Wang, Zhilong Chen, Jinyu Han, Mengxia Li, Jie Chen, Tianxia Xiao, Balamurali K Ambati, Lintao Cai, Qing Yang, Nihar R Nayak, Jian Zhang, Xiujun Fan
Rationale: The availability of therapeutics to treat pregnancy complications is severely lacking, mainly due to the risk of harm to the fetus. In placental malaria, Plasmodium falciparum- infected erythrocytes (IEs) accumulate in the placenta by adhering to chondroitin sulfate A (CSA) on the surfaces of trophoblasts. Based on this principle, we have developed a method for targeted delivery of payloads to the placenta using a synthetic placental CSA-binding peptide (plCSA-BP) derived from VAR2CSA, a CSA-binding protein expressed on IEs...
2018: Theranostics
https://www.readbyqxmd.com/read/29773977/journey-to-the-center-of-the-fetal-brain-environmental-exposures-and-autophagy
#15
REVIEW
Jun Lei, Pilar Calvo, Richard Vigh, Irina Burd
Fetal brain development is known to be affected by adverse environmental exposures during pregnancy, including infection, inflammation, hypoxia, alcohol, starvation, and toxins. These exposures are thought to alter autophagy activity in the fetal brain, leading to adverse perinatal outcomes, such as cognitive and sensorimotor deficits. This review introduces the physiologic autophagy pathways in the fetal brain. Next, methods to detect and monitor fetal brain autophagy activity are outlined. An additional discussion explores possible mechanisms by which environmental exposures during pregnancy alter fetal brain autophagy activity...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29772318/endovascular-management-of-a-large-persistent-sciatic-artery-aneurysm
#16
Tazo Inui, Andrew Picel, Andrew Barleben, John S Lane
The persistent sciatic artery (PSA) is a remnant of the fetal circulatory system that is preserved in less than 0.1% of the population. Up to 60% of patients with this vascular anomaly will go on to development of a PSA aneurysm (PSAA), which can produce a variety of symptoms including neuropathy, claudication, and acute limb-threatening ischemia. Historical management is by open operation and interposition grafting, which can be highly morbid. We describe successful management of a large, symptomatic PSAA by endovascular stent-grafting with intermediate term follow-up...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29772225/maternal-one-carbon-metabolism-through-increased-oxidative-stress-and-disturbed-angiogenesis-can-influence-placental-apoptosis-in-preeclampsia
#17
REVIEW
Vaishali V Kasture, Deepali P Sundrani, Sadhana R Joshi
Adequate maternal nutrition is critical for a healthy pregnancy outcome and poor maternal nutrition is known to be associated with pregnancy complications like preeclampsia. We have earlier demonstrated that there is an imbalance in the levels of micronutrients (folate and vitamin B12 ) along with low levels of long chain polyunsaturated fatty acids (LCPUFA) and high homocysteine levels in women with preeclampsia. Homocysteine is known to be involved in the formation of free radicals leading to increased oxidative stress...
May 14, 2018: Life Sciences
https://www.readbyqxmd.com/read/29771301/anti-tnf-levels-in-cord-blood-at-birth-are-associated-with-anti-tnf-type
#18
Shannon L Kanis, Alison de Lima, Cokkie van der Ent, Dimitris Rizopoulos, C Janneke van der Woude
Background and Aims: Pregnancy guidelines for women with Inflammatory Bowel Disease (IBD) provide recommendations regarding anti-TNF cessation during pregnancy, in order to limit fetal exposure. Although infliximab (IFX) leads to higher anti-TNF concentrations in cord blood than adalimumab (ADA), recommendations are similar. We aimed to demonstrate the effect of anti-TNF cessation during pregnancy on fetal exposure, for IFX and ADA separately. Methods: We conducted a prospective single center cohort study...
May 15, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29771299/at-the-crossroads-of-fate-somatic-cell-lineage-specification-in-the-fetal-gonad
#19
Emmi Rotgers, Anne Jørgensen, Humphrey Hung-Chang Yao
The reproductive endocrine systems are vastly different between male and female. This sexual dimorphism of endocrine milieu originates from sex-specific differentiation of the somatic cells in the gonads during fetal life. The majority of gonadal somatic cells arise from the adrenogonadal primordium. After separation of the adrenal and gonadal primordia, the gonadal somatic cells initiate sex-specific differentiation during gonadal sex determination with the specification of the supporting cell lineages: Sertoli cells in the testis vs...
May 15, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29770989/vitrification-for-bovine-embryos-with-low-quality-grade
#20
Hiroshi Tajimi, Tsugumi Yamazaki, Syoko Oike, Tatsuyuki Yoshida, Konosuke Okada, Masashige Kuwayama, Hitoshi Ushijima
This study was conducted to examine the utility of vitrification for bovine embryos with low-quality grade, and simple cryoprotectants dilution method for practitioners. In Experiment 1, survival of frozen embryos was compared with that of vitrified embryos using minimum volume cooling (MVC). Then, vitrified embryos were used to confirm the optimum sucrose concentration in Experiment 2. The survival rates of embryos that had been vitrified following diluted cryoprotectants with the one-step in-straw method were compared with those of fresh control embryos in Experiment 3...
May 17, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
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