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https://www.readbyqxmd.com/read/29342143/regulation-of-embryonic-haematopoietic-multipotency-by-ezh1
#1
Linda T Vo, Melissa A Kinney, Xin Liu, Yuannyu Zhang, Jessica Barragan, Patricia M Sousa, Deepak K Jha, Areum Han, Marcella Cesana, Zhen Shao, Trista E North, Stuart H Orkin, Sergei Doulatov, Jian Xu, George Q Daley
All haematopoietic cell lineages that circulate in the blood of adult mammals derive from multipotent haematopoietic stem cells (HSCs). By contrast, in the blood of mammalian embryos, lineage-restricted progenitors arise first, independently of HSCs, which only emerge later in gestation. As best defined in the mouse, 'primitive' progenitors first appear in the yolk sac at 7.5 days post-coitum. Subsequently, erythroid-myeloid progenitors that express fetal haemoglobin, as well as fetal lymphoid progenitors, develop in the yolk sac and the embryo proper, but these cells lack HSC potential...
January 17, 2018: Nature
https://www.readbyqxmd.com/read/29341510/maternity-ultrasound-in-the-republic-of-ireland-2016-a-review
#2
D Hayes-Ryan, K McNamara, N Russell, L Kenny, K O'Donoghue
Antenatal ultrasound, comprising of a dating ultrasound in the late first trimester followed by a fetal anomaly scan, is a recognised and necessary component of good antenatal care. We conducted a telephone survey of all 19 obstetric units to ascertain the status of maternity ultrasound provision in Ireland. Fetal anomaly ultrasound is offered universally to all women in 7/19 (37%) units, selectively to some women in 7/19 (37%) units and not offered at all in the remaining 5/19 (26%) units. Overall ? 41,700 (64%) women receive a fetal anomaly ultrasound nationally...
August 8, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29341271/review-shows-that-early-fetal-alcohol-exposure-may-cause-adverse-effects-even-when-the-mother-consumes-low-levels
#3
Ihsan Sarman
AIM: Studies are increasingly focusing on the effects of prenatal alcohol exposure (PAE) on child health. The aim of this review was to provide paediatricians with new insights to help them communicate key messages about avoiding alcohol during pregnancy. METHODS: Inspired by the 7th International Conference on Fetal Alcohol Spectrum Disorder, which focused on integrating research, policy and practice, we studied English language papers published since 2010 on how early PAE triggered epigenetic mechanisms that had an impact on the development of some chronic diseases...
January 17, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29341015/in-utero-mri-of-mouse-embryos
#4
Jiangyang Zhang, Dan Wu, Daniel H Turnbull
Genetically engineered mouse models are used extensively as models of human development and developmental diseases. Conventional histological approaches are static and two-dimensional, and do not provide a full understanding of the dynamic, spatiotemporal changes in developing mouse embryos. Magnetic resonance imaging (MRI) offers a noninvasive and longitudinal approach for three-dimensional in utero imaging of normal and mutant mouse embryos. In this chapter, we describe MRI approaches that have been developed for imaging the living embryonic mouse brain and vasculature...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29339719/mir-181a-5p-suppresses-invasion-and-migration-of-htr-8-svneo-cells-by-directly-targeting-igf2bp2
#5
Liang Wu, Wen-Yan Song, Ya Xie, Lin-Li Hu, Xiao-Man Hou, Rui Wang, Yang Gao, Jing-Na Zhang, Le Zhang, Wei-Wei Li, Cheng Zhu, Zhi-Ying Gao, Ying-Pu Sun
Pre-eclampsia is a pregnancy-related disease that may cause maternal, neonatal and fetal morbidity and mortality and exists in 3-5% of pregnancies worldwide. The discovery of dysregulated microRNAs and their roles in placental development has provided a new avenue for elucidating the mechanism involved in this pregnancy-specific disorder. Here, the roles of human miR-181a-5p, a microRNA that is increased in both the plasma and placenta of severe pre-eclamptic patients, in invasion and migration of trophoblasts were investigated...
January 16, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29338033/intermittent-low-dose-carbon-monoxide-exposure-enhances-survival-and-dopaminergic-differentiation-of-human-neural-stem-cells
#6
Nanna Dreyer-Andersen, Ana Sofia Almeida, Pia Jensen, Morad Kamand, Justyna Okarmus, Tine Rosenberg, Stig Düring Friis, Alberto Martínez Serrano, Morten Blaabjerg, Bjarne Winther Kristensen, Troels Skrydstrup, Jan Bert Gramsbergen, Helena L A Vieira, Morten Meyer
Exploratory studies using human fetal tissue have suggested that intrastriatal transplantation of dopaminergic neurons may become a future treatment for patients with Parkinson's disease. However, the use of human fetal tissue is compromised by ethical, regulatory and practical concerns. Human stem cells constitute an alternative source of cells for transplantation in Parkinson's disease, but efficient protocols for controlled dopaminergic differentiation need to be developed. Short-term, low-level carbon monoxide (CO) exposure has been shown to affect signaling in several tissues, resulting in both protection and generation of reactive oxygen species...
2018: PloS One
https://www.readbyqxmd.com/read/29337851/transcriptional-regulation-by-cpg-sites-methylation-in-the-core-promoter-region-of-the-bovine-six1-gene-roles-of-histone-h4-and-e2f2
#7
Dawei Wei, Anning Li, Chunping Zhao, Hongbao Wang, Chugang Mei, Rajwali Khan, Linsen Zan
DNA methylation is a major epigenetic modification of the genome and has an essential role in muscle development. The SIX1 gene is thought to play a principal role in mediating skeletal muscle development. In the present study, we determined that bovine SIX1 expression levels were significantly higher in the fetal bovine group (FB) and in undifferentiated Qinchuan cattle muscle cells (QCMCs) than in the adult bovine group (AB) and in differentiated QCMCs. Moreover, a bisulfite sequencing polymerase chain reaction (BSP) analysis of DNA methylation levels showed that three CpG sites in the core promoter region (-216/-28) of the bovine SIX1 gene exhibited significantly higher DNA methylation levels in the AB and differentiated QCMCs groups...
January 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29336488/neonatal-ethanol-exposure-causes-behavioral-deficits-in-young-mice
#8
Wenhua Xu, Andrew B Hawkey, Hui Li, Lu Dai, Howard H Brim, Jacqueline A Frank, Jia Luo, Susan Barron, Gang Chen
BACKGROUND: Fetal ethanol (ETOH) exposure can damage the developing central nervous system and lead to cognitive and behavioral deficits, known as fetal alcohol spectrum disorders (FASD). ETOH exposure to mouse pups during early neonatal development was used as a model of ETOH exposure that overlaps the human third trimester "brain growth spurt" - a model that has been widely used to study FASD in rats. METHODS: C57BL/6 male and female mice were exposed to ETOH (4 g/kg/day) on postnatal days (PD) 4-10 by oral intubation...
January 16, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29336372/effects-of-matricaria-chamomilla-extract-on-growth-and-maturation-of-isolated-mouse-ovarian-follicles-in-a-three-dimensional-culture-system
#9
Hamed Shoorei, Arash Khaki, Nava Ainehchi, Mohammad Mehdi Hassanzadeh Taheri, Moloud Tahmasebi, Giti Seyedghiasi, Ziba Ghoreishi, Majid Shokoohi, Amir Afshin Khaki, Sayed Haidar Abbas Raza
BACKGROUND: The aim of this study was to design and assess the effects of hydroalcoholic extract of Matricaria chamomilla (MC) on preantral follicle culture of mouse ovaries in a three-dimensional culture system. METHODS: Isolated preantral follicles were randomly divided into three main groups: the control group containing 10% fetal bovine serum without MC extract (G1), the first experimental group supplemented with 25 μg/ml hydroalcoholic extract of chamomile (G2), and the second experimental group supplemented with 50 μg/ml hydroalcoholic extract of chamomile (G3)...
January 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29336267/stem-cells-derived-from-amniotic-fluid-a-potential-pluripotent-like-cell-source-for-cellular-therapy
#10
Thamil Selvee Ramasamy, Vithya Velaithan, Yelena Yeow, Fazlul H Sarkar
BACKGROUND: Regenerative medicine aims to provide therapeutic treatment for disease or injury, and cell-based therapy is a newer therapeutic approach that the conventional medicine cannot do. The ethical issues rose by the utilisation of human embryonic stem cells (hESC) and the limited capacity of adult stem cells, however, hinder the application of these stem cells in regenerative medicine. Recently, isolation and characterisation of c-kit positive cells from human amniotic fluid, which possess intermediate characteristics between hESCs and adult stem cells, provided a new approach towards realising their promise for fetal and adult regenerative medicine...
January 14, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29335781/peripartum-events-associated-with-severe-neurologic-morbidity-and-mortality-among-acidemic-neonates
#11
Sivan Zuarez-Easton, Sally Hosary, Noah Zafran, Gali Garmi, Clari Felszer, Raed Salim
PURPOSE: To identify peripartum events that may predict the development of short-term neurologic morbidity and mortality among acidemic neonates. METHODS: Retrospective case-control study conducted at a single-teaching hospital on data from January 2010 to December 2015. The study cohort group included all acidemic neonates (cord artery pH ≤ 7.1) born at ≥ 34 weeks. Primary outcome was a composite including any of the following: neonatal encephalopathy, convulsions, intra-ventricular hemorrhage, or neonatal death...
January 15, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29335447/exposure-to-famine-in-early-life-and-chronic-kidney-diseases-in-adulthood
#12
Ningjian Wang, Zhiyuan Ning, Fangzhen Xia, Chi Chen, Jing Cheng, Yi Chen, Yingli Lu
OBJECTIVE: Chronic kidney disease (CKD) is an increasing contributor to the global disease burden. Previous findings indicated that exposure to famine in early life was associated with various metabolic diseases and urinary protein levels. We aimed to assess whether the exposure to China's Great Famine 1959-1962 during fetal or childhood period was associated with glomerular filtration rate (GFR) and risk of CKD (eGFR<60 mL/min per 1.73 m2) in adulthood. MATERIALS AND METHODS: SPECT-China was a population-based observational study in 2014-2015...
January 15, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29335381/the-fetal-programming-of-telomere-biology-hypothesis-an-update
#13
REVIEW
Sonja Entringer, Karin de Punder, Claudia Buss, Pathik D Wadhwa
Research on mechanisms underlying fetal programming of health and disease risk has focused primarily on processes that are specific to cell types, organs or phenotypes of interest. However, the observation that developmental conditions concomitantly influence a diverse set of phenotypes, the majority of which are implicated in age-related disorders, raises the possibility that such developmental conditions may additionally exert effects via a common underlying mechanism that involves cellular/molecular ageing-related processes...
March 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29335024/sex-differences-in-the-late-first-trimester-human-placenta-transcriptome
#14
Tania L Gonzalez, Tianyanxin Sun, Alexander F Koeppel, Bora Lee, Erica T Wang, Charles R Farber, Stephen S Rich, Lauren W Sundheimer, Rae A Buttle, Yii-Der Ida Chen, Jerome I Rotter, Stephen D Turner, John Williams, Mark O Goodarzi, Margareta D Pisarska
BACKGROUND: Development of the placenta during the late first trimester is critical to ensure normal growth and development of the fetus. Developmental differences in this window such as sex-specific variation are implicated in later placental disease states, yet gene expression at this time is poorly understood. METHODS: RNA-sequencing was performed to characterize the transcriptome of 39 first trimester human placentas using chorionic villi following genetic testing (17 females, 22 males)...
January 15, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/29334489/association-between-arterial-stiffness-and-wave-reflection-with-subsequent-development-of-placental-mediated-diseases-during-pregnancy-findings-of-a-systematic-review-and-meta-analysis
#15
Mohamed Waseem Osman, Mintu Nath, Eamonn Breslin, Asma Khalil, David R Webb, Thompson G Robinson, Hatem A Mousa
OBJECTIVE: We present a comprehensive systematic review of published literature to examine, whether arterial stiffness and wave reflection measurements during pregnancy differed between healthy patients and patients with placental-mediated diseases including preeclampsia (PET), small for gestational age (SGA), fetal death, and placental abruption, and a quantitative assessment of the findings using the meta-analysis approach. METHODS: We searched Medline, Embase, and The Cochrane Library for studies of arterial stiffness in pregnancy, analyzed pregnancy outcomes and conducted the meta-analysis of data evaluated by trimesters of pregnancy...
January 13, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29334402/noninvasive-reconstruction-of-placental-methylome-from-maternal-plasma-dna-potential-for-prenatal-testing-and-monitoring
#16
Kun Sun, Fiona M F Lun, Tak Y Leung, Rossa W K Chiu, Y M Dennis Lo, Hao Sun
OBJECTIVE: During human pregnancy, the DNA methylation of placental tissue is highly relevant to the normal growth and development of the fetus, therefore methylomic analysis of the placental tissue possesses high research and clinical value in prenatal testing and monitoring. Thus our aim is to develop an approach for reconstruction of the placental methylome, which should be completely noninvasive and achieve high accuracy and resolution. RESULTS: We propose a novel size-based algorithm, FEMER, to noninvasively reconstruct the placental methylome by genomewide bisulfite sequencing and size-based analysis of maternal plasma DNA...
January 15, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29334210/combined-effect-of-retinoic-acid-and-basic-fibroblast-growth-factor-on-maturation-of-mouse-oocyte-and-subsequent-fertilization-and-development
#17
Morteza Abouzaripour, Fardin Fathi, Erfan Daneshi, Keywan Mortezaee, Mohammad Jafar Rezaie, Mahdad Abdi
Background: In this experimental study, germinal vesicle (GV) oocytes obtained from two-months-old NMRI mice were randomly divided into control, sham and three experimental groups. The basic culture medium was α-MEM supplemented with 10% fetal bovine serum (FBS), 50 mg/l streptomycin, 60 mg/l penicillin and 10 ng/ ml epidermal growth factors. Each of the experimental groups received one of the following treatments: RA (2 μM), bFGF (20 ng/ml) or combination of RA and bFGF with the indicated concentrations...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29331935/disruption-of-thyroid-hormone-sulfotransferase-activity-by-brominated-flame-retardant-chemicals-in-the-human-choriocarcinoma-placenta-cell-line-bewo
#18
Christopher P Leonetti, Craig M Butt, Heather M Stapleton
Brominated flame retardants (BFRs) have been shown to disrupt thyroid hormone (TH) homeostasis through multiple mechanisms, including inhibition of enzymes that regulate intracellular levels of THs, such as sulfotransferases (SULTs). The placenta plays a critical role in helping to maintain TH levels during fetal development and expresses SULTs. This is concerning given that disruption of TH regulation within the placenta could potentially harm the developing fetus. In this study, we investigated the effects of two polybrominated diphenyl ethers (PBDEs), two hydroxylated PBDEs, and 2,4,6-tribromophenol (2,4,6-TBP) on TH SULT activity in a choriocarcinoma placenta cell line (BeWo)...
December 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/29331830/fetal-development-of-the-poeppig-s-woolly-monkey-lagothrix-poeppigii
#19
Rafael Dos Santos de Andrade, Frederico Ozanan Barros Monteiro, Hani Rocha El Bizri, Wilter Ricardo Russiano Vicente, Diva Anelie de Araujo Guimarães, Pedro Mayor
The intrauterine development is an evolutionary strategy that prepares the neonate for extra-uterine life, thus providing important information on the life history of species. In this study, we described the external and internal morphology of 25 fetuses of Poeppig's woolly monkeys (Lagothrix poeppigii) by taking advantage of a 10-year participatory collection of biological samples originated from animals hunted for subsistence purposes in the Peruvian Amazon. Logistic regressions estimated the probability of occurrence of each external morphological characteristic in relation to the crown-rump length (CRL)...
December 8, 2017: Theriogenology
https://www.readbyqxmd.com/read/29331534/perinatal-palliative-care-integration-in-a-united-states-nurse-midwifery-education-program
#20
Jenna A LoGiudice, Eileen O'Shea
Midwifery students with perinatal palliative care education develop a skillset to provide holistic midwifery care to women and families who are experiencing stillbirth or life-limiting fetal diagnoses. This paper presents a model of perinatal palliative care in a United States midwifery education program. By utilizing evidence based practices and national programs, perinatal palliative care can be threaded through midwifery curricula to achieve international standards of practice and competencies. Most importantly, enhancing perinatal palliative care education will better prepare future midwives for when a birth outcome is not what was expected at the outset of a pregnancy...
December 28, 2017: Midwifery
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