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https://www.readbyqxmd.com/read/27855590/survival-of-kidney-retransplant-compared-with-first-kidney-transplant-a-report-from-southern-iran
#1
Jamshid Roozbeh, Leila Malekmakan, Mehri Monavarian, Arghavan Daneshian, Zeynab Karimi
OBJECTIVES: Kidney retransplant is increasingly performed, but patient survival is controversial. The aim of this study was to evaluate the outcomes of patients with second kidney grafts and compare survival rates of recipients with first and second kidney transplant procedures. MATERIALS AND METHODS: This was a retrospective study analyzing records from the Shiraz University of Medical Sciences transplant ward. Survival rates of retrans?lanted patients were compared with a randomly selected group of first kidney recipients...
November 18, 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27578428/immunosuppressive-therapy-for-kidney-transplantation-in-adults-a-systematic-review-and-economic-model
#2
Tracey Jones-Hughes, Tristan Snowsill, Marcela Haasova, Helen Coelho, Louise Crathorne, Chris Cooper, Ruben Mujica-Mota, Jaime Peters, Jo Varley-Campbell, Nicola Huxley, Jason Moore, Matt Allwood, Jenny Lowe, Chris Hyde, Martin Hoyle, Mary Bond, Rob Anderson
BACKGROUND: End-stage renal disease is a long-term irreversible decline in kidney function requiring renal replacement therapy: kidney transplantation, haemodialysis or peritoneal dialysis. The preferred option is kidney transplantation, followed by immunosuppressive therapy (induction and maintenance therapy) to reduce the risk of kidney rejection and prolong graft survival. OBJECTIVES: To review and update the evidence for the clinical effectiveness and cost-effectiveness of basiliximab (BAS) (Simulect(®), Novartis Pharmaceuticals UK Ltd) and rabbit anti-human thymocyte immunoglobulin (rATG) (Thymoglobulin(®), Sanofi) as induction therapy, and immediate-release tacrolimus (TAC) (Adoport(®), Sandoz; Capexion(®), Mylan; Modigraf(®), Astellas Pharma; Perixis(®), Accord Healthcare; Prograf(®), Astellas Pharma; Tacni(®), Teva; Vivadex(®), Dexcel Pharma), prolonged-release tacrolimus (Advagraf(®) Astellas Pharma), belatacept (BEL) (Nulojix(®), Bristol-Myers Squibb), mycophenolate mofetil (MMF) (Arzip(®), Zentiva; CellCept(®), Roche Products; Myfenax(®), Teva), mycophenolate sodium (MPS) (Myfortic(®), Novartis Pharmaceuticals UK Ltd), sirolimus (SRL) (Rapamune(®), Pfizer) and everolimus (EVL) (Certican(®), Novartis) as maintenance therapy in adult renal transplantation...
August 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27557331/immunosuppressive-therapy-for-kidney-transplantation-in-children-and-adolescents-systematic-review-and-economic-evaluation
#3
Marcela Haasova, Tristan Snowsill, Tracey Jones-Hughes, Louise Crathorne, Chris Cooper, Jo Varley-Campbell, Ruben Mujica-Mota, Helen Coelho, Nicola Huxley, Jenny Lowe, Jan Dudley, Stephen Marks, Chris Hyde, Mary Bond, Rob Anderson
BACKGROUND: End-stage renal disease is a long-term irreversible decline in kidney function requiring kidney transplantation, haemodialysis or peritoneal dialysis. The preferred option is kidney transplantation followed by induction and maintenance immunosuppressive therapy to reduce the risk of kidney rejection and prolong graft survival. OBJECTIVES: To systematically review and update the evidence for the clinical effectiveness and cost-effectiveness of basiliximab (BAS) (Simulect,(®) Novartis Pharmaceuticals) and rabbit antihuman thymocyte immunoglobulin (Thymoglobuline,(®) Sanofi) as induction therapy and immediate-release tacrolimus [Adoport(®) (Sandoz); Capexion(®) (Mylan); Modigraf(®) (Astellas Pharma); Perixis(®) (Accord Healthcare); Prograf(®) (Astellas Pharma); Tacni(®) (Teva); Vivadex(®) (Dexcel Pharma)], prolonged-release tacrolimus (Advagraf,(®) Astellas Pharma); belatacept (BEL) (Nulojix,(®) Bristol-Myers Squibb), mycophenolate mofetil (MMF) [Arzip(®) (Zentiva), CellCept(®) (Roche Products), Myfenax(®) (Teva), generic MMF is manufactured by Accord Healthcare, Actavis, Arrow Pharmaceuticals, Dr Reddy's Laboratories, Mylan, Sandoz and Wockhardt], mycophenolate sodium, sirolimus (Rapamune,(®) Pfizer) and everolimus (Certican,(®) Novartis Pharmaceuticals) as maintenance therapy in children and adolescents undergoing renal transplantation...
August 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27498898/acute-renal-failure-a-serious-complication-in-patients-after-kidney-transplantation
#4
G Basta-Jovanovic, Lj Bogdanovic, M Radunovic, M Prostran, R Naumovic, S Simic-Ogrizovic, S Radojevic-Skodric
Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails...
2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27471740/the-effect-of-cytomegalovirus-infection-on-acute-rejection-in-kidney-transplanted-patients
#5
Boshra Hasanzamani, Maryam Hami, Vajihe Zolfaghari, Mahtab Torkamani, Mahin Ghorban Sabagh, Saiideh Ahmadi Simab
INTRODUCTION: It is known that cytomegalovirus (CMV) infection is a common problem among kidney transplant patients. This infection can be increased morbidity and decreased graft survival. This problem has been associated with acute rejection too. PATIENTS AND METHODS: One hundred and thirty renal transplant patients were included in a prospective, case-control study. The renal transplant patients were divided into two groups; patients group with CMV infection and control group without CMV infection...
2016: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/27414253/the-tgf-%C3%AE-activated-long-non-coding-rna-atb-plays-an-important-role-in-acute-rejection-of-renal-allografts-and-may-impacts-the-postoperative-pharmaceutical-immunosuppression-therapy
#6
Jiang Qiu, Yehui Chen, Gang Huang, Zhi Zhang, Lizhong Chen, Ning Na
AIM: Long noncoding RNAs (lncRNAs) are novel intracellular noncoding ribonucleotides regulating the genome and proteome. The lncRNA activated by transforming growth factor β (TGF-β) (lncRNA-ATB) was discovered as a prognostic factor in hepatocellular carcinoma, gastric cancer, and colorectal cancer. However, little is known about the role of lncRNA-ATB in renal transplantation. This study aimed to assess lncRNA-ATB expression in renal transplant patients with acute kidney injury and explore its role in postoperative pharmaceutical immunosuppression therapy...
July 14, 2016: Nephrology
https://www.readbyqxmd.com/read/27216760/risk-of-solid-organ-transplant-rejection-following-vaccination-with-seasonal-trivalent-inactivated-influenza-vaccines-in-england-a-self-controlled-case-series
#7
Gaël Dos Santos, François Haguinet, Catherine Cohet, Dave Webb, John Logie, Germano L C Ferreira, Dominique Rosillon, Vivek Shinde
BACKGROUND: Annual seasonal influenza vaccination is recommended for transplant recipients. No formal pharmacoepidemiology study has been published on the association between solid organ transplant (SOT) rejection and vaccination with seasonal trivalent inactivated influenza vaccines (TIIVs). METHODS: The risk of SOT (liver, kidney, lung, heart or pancreas) rejection after TIIV vaccination was assessed using a self-controlled case-series method (NCT01715792). SOT recipients in England with transplant rejection were selected from the Clinical Practice Research Datalink and linked Hospital Episode Statistics inpatient data...
June 30, 2016: Vaccine
https://www.readbyqxmd.com/read/27126975/effect-of-fty720-fingolimod-on-graft-survival-in-renal-transplant-recipients-a-systematic-review-protocol
#8
Reza Gholamnezhadjafari, Reza Falak, Nader Tajik, Reza Aflatoonian, Abbas Ali Keshtkar, Abbas Rezaei
INTRODUCTION: Studies have shown that FTY720 has inconsistent effects in kidney transplant recipients. Several review articles on FTY720 have been published, but most have focused on the mechanism of action of FTY720. Therefore, this review aims to evaluate and determine the beneficial and harmful effects of FTY720 therapy in kidney transplant recipients. METHODS AND ANALYSIS: We electronically searched the following databases: PubMed, Scopus, the Web of Sciences, EMBASE, Cochrane databases and the Cochrane Central Registry of Controlled Trials...
2016: BMJ Open
https://www.readbyqxmd.com/read/27081421/an-insight-into-the-immunologic-events-and-risk-assessment-in-renal-transplantation
#9
REVIEW
Asif Khan, Patricia Nasr, Elie El-Charabaty, Suzanne El-Sayegh
Organ transplantation has always been considered to be the optimal therapeutic intervention in patients with end-stage organ failure. In the US, approximately 615,000 patients are diagnosed with end-stage renal disease and less than 30% have received a kidney transplant. One of the crucial drawbacks in successful renal transplantation is allograft rejection. Survival rates among transplant recipients have greatly improved due to better understanding of transplant biology and more effective immunosuppressive agents...
May 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/26907182/acute-renal-failure-in-transplanted-kidneys
#10
G Basta-Jovanovic, Lj Bogdanovic, M Radunovic, M Prostran, R Naumovic, S Simic-Ogrizovic, S Radojevic-Skodric
Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails...
February 24, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/26892892/administration-of-antithymocyte-globulin-rabbit-to-treat-a-severe-mixed-rejection-episode-in-a-pregnant-renal-transplant-recipient
#11
Heather L Kutzler, Xiaoyi Ye, Caroline Rochon, Spencer T Martin
Pregnancy in solid organ transplant recipients carries numerous risks to the mother such as increased risk of rejection, gestational diabetes mellitus, and preeclampsia. The developing fetus is subjected to risks such as birth defects, preterm delivery, and low birth weight. Typically, these risks can be managed through intensive, multidisciplinary prenatal care and a proper immunosuppressive regimen. In the setting of rejection, however, little data are available to suggest safe and effective treatment of acute cellular rejection, antibody-mediated rejection, or mixed rejection episodes in the pregnant solid organ transplant recipient...
April 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/26506996/long-noncoding-rnas-in-urine-are-detectable-and-may-enable-early-detection-of-acute-t-cell-mediated-rejection-of-renal-allografts
#12
Johan M Lorenzen, Celina Schauerte, Malte Kölling, Anika Hübner, Monika Knapp, Hermann Haller, Thomas Thum
BACKGROUND: Long noncoding RNAs (lncRNAs) are novel intracellular noncoding ribonucleotides regulating the genome and proteome. They are detectable in the blood of patients with acute kidney injury. We tested whether lncRNAs are present in urine and may serve as new predictors of outcome in renal transplant patients with acute rejection. METHODS: A global lncRNA expression analysis was performed with RNA from urine of patients with acute T cell-mediated renal allograft rejection and control transplant patients...
December 2015: Clinical Chemistry
https://www.readbyqxmd.com/read/26313144/a-linear-mixed-model-spline-framework-for-analysing-time-course-omics-data
#13
Jasmin Straube, Alain-Dominique Gorse, Bevan Emma Huang, Kim-Anh Lê Cao
Time course 'omics' experiments are becoming increasingly important to study system-wide dynamic regulation. Despite their high information content, analysis remains challenging. 'Omics' technologies capture quantitative measurements on tens of thousands of molecules. Therefore, in a time course 'omics' experiment molecules are measured for multiple subjects over multiple time points. This results in a large, high-dimensional dataset, which requires computationally efficient approaches for statistical analysis...
2015: PloS One
https://www.readbyqxmd.com/read/25624053/long-term-successful-outcomes-from-kidney-transplantation-after-lung-and-heart-lung-transplantation
#14
Shinji Otani, Bronwyn J Levvey, Glen P Westall, Miranda Paraskeva, Helen Whitford, Trevor Williams, David C McGiffin, Rowan Walker, Solomon Menahem, Gregory I Snell
BACKGROUND: Renal dysfunction is common after lung and heart-lung transplantation (Tx), and it limits the recipient's survival and quality of life. This study analyzed the outcomes of simultaneous and late kidney Tx following lung and heart-lung Tx. METHODS: From a single-center retrospective chart review of 1031 lung and heart-lung Tx recipients, we identified 13 simultaneous or late kidney Tx cases in 12 patients. RESULTS: Three patients underwent simultaneous deceased donor lung and kidney Tx...
March 2015: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/25362901/acute-allograft-rejection-following-interferon-therapy-for-hepatitis-c-in-recipients-who-have-returned-to-dialysis-after-kidney-transplant-failure-case-study
#15
Fabrizio Fabrizi, Roberta D'Ambrosio, Francesco Pallotti, Luisa Berardinelli, Piergiorgio Messa, Paul Martin, Alessio Aghemo
Interferon-based therapy remains the gold standard for hepatitis C in patients with chronic kidney disease; however, due to the high rate of IFN-induced rejection after transplant, treatment of HCV-infected kidney transplant recipients is recommended only in particular circumstances. We report the case of a 45-year-old Caucasian female with chronic hepatitis C (genotype 1b) who returned to hemodialysis following the complete functional loss of her kidney transplant. She started combination antiviral therapy with peg-IFN-α2a (135 mcg sc weekly) plus ribavirin (200 mg daily) nine months after the re-initiation of hemodialysis...
November 2014: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/25277265/a-retrospective-analysis-of-pregnancy-outcomes-after-kidney-transplantation-in-a-single-center
#16
Munire Erman Akar, Murat Ozekinci, Cem Sanhal, Nilgun Kececioglu, Inanc Mendilcioglu, Yesim Senol, Kerem Dirican, Huseyin Kocak, Ayhan Dinckan, Gultekin Suleymanlar
BACKGROUND: We reported pregnancy outcomes after kidney transplantation in a single transplant center. METHODS: We reviewed the perinatal outcomes of female kidney transplant patients of reproductive age (18-40 years) from 1987 to 2011. RESULTS: A total of 246 patients were reviewed. Of these, 43 women registered a pregnancy following kidney transplantation. The mean patient age was 31.3 ± 4.2 years (range 24-40). The mean transplant-conception interval was 35...
2015: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/25220222/steroid-avoidance-or-withdrawal-for-pancreas-and-pancreas-with-kidney-transplant-recipients
#17
REVIEW
Nuria Montero, Angela C Webster, Ana Royuela, Javier Zamora, Marta Crespo Barrio, Julio Pascual
BACKGROUND: Pancreas or kidney-pancreas transplantation improves survival and quality of life for people with type 1 diabetes mellitus and kidney failure. Immunosuppression after transplantation is associated with complications. Steroids have adverse effects on cardiovascular risk factors such as hypertension, hyperglycaemia or hyperlipidaemia, increase risk of infection, obesity, cataracts, myopathy, bone metabolism alterations, dermatologic problems and cushingoid appearance. Whether avoiding steroids changes outcomes is unclear...
2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25195555/incidence-and-impact-of-rejection-following-simultaneous-liver-kidney-transplantation
#18
Kathy M Nilles, James Krupp, Brittany Lapin, Nedjema Sustento-Reodica, Lorenzo Gallon, Josh Levitsky
BACKGROUND & AIMS: Due to hepatic immunoregulation, simultaneous liver-kidney recipients are presumed to be reasonably protected from kidney rejection and typically receive less immunosuppression compared to kidney transplants alone. However, data to support these conclusions and practices are sparse. METHODS: We characterized the incidence and types of rejection, graft function, and graft and patient survival in a large population of simultaneous liver-kidney recipients (n=140) with long-term follow-up at our centre (1998-2010)...
February 2015: Journal of Hepatology
https://www.readbyqxmd.com/read/25032135/local-graft-irradiation-for-kidney-allograft-rejection-a-case-series-and-review-of-the-literature
#19
Mohammad Kazem Fallahzadeh, Sarah Khan, Gazi B Zibari, Sandeep Patil, Neeraj Singh
INTRODUCTION: Due to its immunosuppressive properties, local graft irradiation (LGI) has been proposed as a second line therapy for treatment of acute kidney rejection. CASE PRESENTATION: In this case-series we report 6 patients with biopsy proven acute kidney allograft rejection refractory to conventional antirejection therapy who underwent LGI for treatment of acute rejection at our center. Three of these patients had living donor transplants, 2 had deceased donor transplants, and one had received a simultaneous kidney/pancreas transplant...
May 2014: Nephro-urology Monthly
https://www.readbyqxmd.com/read/24650200/medicine-non-adherence-in-kidney-transplantation
#20
REVIEW
Allison Fiona Williams, Elizabeth Manias, Cadeyrn J Gaskin, Kimberley Crawford
BACKGROUND: The increasing prevalence of chronic kidney disease, the relative shortage of kidney donors and the economic- and health-related costs of kidney transplant rejection make the prevention of adverse outcomes following transplantation a healthcare imperative. Although strict adherence to immunosuppressant medicine regimens is key to preventing kidney rejection, evidence suggests that adherence is sub-optimal. Strategies need to be developed to help recipients of kidney transplants adhere to their prescribed medicines...
June 2014: Journal of Renal Care
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