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https://www.readbyqxmd.com/read/27498898/acute-renal-failure-a-serious-complication-in-patients-after-kidney-transplantation
#1
G Basta-Jovanovic, Lj Bogdanovic, M Radunovic, M Prostran, R Naumovic, S Simic-Ogrizovic, S Radojevic-Skodric
Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails...
2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27471740/the-effect-of-cytomegalovirus-infection-on-acute-rejection-in-kidney-transplanted-patients
#2
Boshra Hasanzamani, Maryam Hami, Vajihe Zolfaghari, Mahtab Torkamani, Mahin Ghorban Sabagh, Saiideh Ahmadi Simab
INTRODUCTION: It is known that cytomegalovirus (CMV) infection is a common problem among kidney transplant patients. This infection can be increased morbidity and decreased graft survival. This problem has been associated with acute rejection too. PATIENTS AND METHODS: One hundred and thirty renal transplant patients were included in a prospective, case-control study. The renal transplant patients were divided into two groups; patients group with CMV infection and control group without CMV infection...
2016: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/27414253/the-tgf-%C3%AE-activated-long-non-coding-rna-atb-plays-an-important-role-in-acute-rejection-of-renal-allografts-and-may-impacts-the-postoperative-pharmaceutical-immunosuppression-therapy
#3
Jiang Qiu, Yehui Chen, Gang Huang, Zhi Zhang, Lizhong Chen, Ning Na
AIM: Long noncoding RNAs (lncRNAs) are novel intracellular noncoding ribonucleotides regulating the genome and proteome. The lncRNA activated by transforming growth factor β (TGF-β) (lncRNA-ATB) was discovered as a prognostic factor in hepatocellular carcinoma, gastric cancer, and colorectal cancer. However, little is known about the role of lncRNA-ATB in renal transplantation. This study aimed to assess lncRNA-ATB expression in renal transplant patients with acute kidney injury and explore its role in postoperative pharmaceutical immunosuppression therapy...
July 14, 2016: Nephrology
https://www.readbyqxmd.com/read/27126975/effect-of-fty720-fingolimod-on-graft-survival-in-renal-transplant-recipients-a-systematic-review-protocol
#4
Reza Gholamnezhadjafari, Reza Falak, Nader Tajik, Reza Aflatoonian, Abbas Ali Keshtkar, Abbas Rezaei
INTRODUCTION: Studies have shown that FTY720 has inconsistent effects in kidney transplant recipients. Several review articles on FTY720 have been published, but most have focused on the mechanism of action of FTY720. Therefore, this review aims to evaluate and determine the beneficial and harmful effects of FTY720 therapy in kidney transplant recipients. METHODS AND ANALYSIS: We electronically searched the following databases: PubMed, Scopus, the Web of Sciences, EMBASE, Cochrane databases and the Cochrane Central Registry of Controlled Trials...
2016: BMJ Open
https://www.readbyqxmd.com/read/26907182/acute-renal-failure-in-transplanted-kidneys
#5
G Basta-Jovanovic, Lj Bogdanovic, M Radunovic, M Prostran, R Naumovic, S Simic-Ogrizovic, S Radojevic-Skodric
Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails...
February 24, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/26506996/long-noncoding-rnas-in-urine-are-detectable-and-may-enable-early-detection-of-acute-t-cell-mediated-rejection-of-renal-allografts
#6
Johan M Lorenzen, Celina Schauerte, Malte Kölling, Anika Hübner, Monika Knapp, Hermann Haller, Thomas Thum
BACKGROUND: Long noncoding RNAs (lncRNAs) are novel intracellular noncoding ribonucleotides regulating the genome and proteome. They are detectable in the blood of patients with acute kidney injury. We tested whether lncRNAs are present in urine and may serve as new predictors of outcome in renal transplant patients with acute rejection. METHODS: A global lncRNA expression analysis was performed with RNA from urine of patients with acute T cell-mediated renal allograft rejection and control transplant patients...
December 2015: Clinical Chemistry
https://www.readbyqxmd.com/read/25624053/long-term-successful-outcomes-from-kidney-transplantation-after-lung-and-heart-lung-transplantation
#7
Shinji Otani, Bronwyn J Levvey, Glen P Westall, Miranda Paraskeva, Helen Whitford, Trevor Williams, David C McGiffin, Rowan Walker, Solomon Menahem, Gregory I Snell
BACKGROUND: Renal dysfunction is common after lung and heart-lung transplantation (Tx), and it limits the recipient's survival and quality of life. This study analyzed the outcomes of simultaneous and late kidney Tx following lung and heart-lung Tx. METHODS: From a single-center retrospective chart review of 1031 lung and heart-lung Tx recipients, we identified 13 simultaneous or late kidney Tx cases in 12 patients. RESULTS: Three patients underwent simultaneous deceased donor lung and kidney Tx...
March 2015: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/25220222/steroid-avoidance-or-withdrawal-for-pancreas-and-pancreas-with-kidney-transplant-recipients
#8
REVIEW
Nuria Montero, Angela C Webster, Ana Royuela, Javier Zamora, Marta Crespo Barrio, Julio Pascual
BACKGROUND: Pancreas or kidney-pancreas transplantation improves survival and quality of life for people with type 1 diabetes mellitus and kidney failure. Immunosuppression after transplantation is associated with complications. Steroids have adverse effects on cardiovascular risk factors such as hypertension, hyperglycaemia or hyperlipidaemia, increase risk of infection, obesity, cataracts, myopathy, bone metabolism alterations, dermatologic problems and cushingoid appearance. Whether avoiding steroids changes outcomes is unclear...
2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25195555/incidence-and-impact-of-rejection-following-simultaneous-liver-kidney-transplantation
#9
Kathy M Nilles, James Krupp, Brittany Lapin, Nedjema Sustento-Reodica, Lorenzo Gallon, Josh Levitsky
BACKGROUND & AIMS: Due to hepatic immunoregulation, simultaneous liver-kidney recipients are presumed to be reasonably protected from kidney rejection and typically receive less immunosuppression compared to kidney transplants alone. However, data to support these conclusions and practices are sparse. METHODS: We characterized the incidence and types of rejection, graft function, and graft and patient survival in a large population of simultaneous liver-kidney recipients (n=140) with long-term follow-up at our centre (1998-2010)...
February 2015: Journal of Hepatology
https://www.readbyqxmd.com/read/25032135/local-graft-irradiation-for-kidney-allograft-rejection-a-case-series-and-review-of-the-literature
#10
Mohammad Kazem Fallahzadeh, Sarah Khan, Gazi B Zibari, Sandeep Patil, Neeraj Singh
INTRODUCTION: Due to its immunosuppressive properties, local graft irradiation (LGI) has been proposed as a second line therapy for treatment of acute kidney rejection. CASE PRESENTATION: In this case-series we report 6 patients with biopsy proven acute kidney allograft rejection refractory to conventional antirejection therapy who underwent LGI for treatment of acute rejection at our center. Three of these patients had living donor transplants, 2 had deceased donor transplants, and one had received a simultaneous kidney/pancreas transplant...
May 2014: Nephro-urology Monthly
https://www.readbyqxmd.com/read/23769040/expression-of-receptor-activator-of-nuclear-factor-kappa-b-ligand-in-leukocytes-during-acute-kidney-rejection-after-transplantation-in-rats
#11
J Spanjol, T Celic, D Markic, G Djordjevic, I Maric, Z Fuckar, S Racki, D Bobinac
BACKGROUND: Acute cellular rejection of the transplanted kidney is an important cause of impaired graft function. One of the basic characteristics of acute cellular rejection according to the latest Banff classification of renal allograft pathology is the presence of a large number of T lymphocytes in the allografted tissue. Osteoprotegerin, receptor activator of nuclear factor-kappa B (RANK) and RANK ligand (RANKL), three relatively novel members of the tumor necrosis factor superfamily, have crucial roles not only in physiologic and pathologic bone metabolism but also in immunologic processes...
June 2013: Transplantation Proceedings
https://www.readbyqxmd.com/read/23477385/relation-between-pretransplant-serum-levels-of-soluble-cd30-and-acute-rejection-during-the-first-6-months-after-a-kidney-transplant
#12
Tina Shooshtarizadeh, Ali Mohammadali, Shahrzad Ossareh, Yousef Ataipour
OBJECTIVES: The immunologic status of kidney allograft recipients affects transplant outcome. High levels of pretransplant serum soluble CD30 correlate with an increased risk of acute rejection. Studies show conflicting results. We evaluated the relation between pretransplant serum sCD30 levels with the risk of posttransplant acute kidney rejection in renal transplant recipients. MATERIALS AND METHODS: This prospective cohort study was performed between March 2010 and March 2011 on 77 kidney transplant recipients (53 men [68...
June 2013: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/23052694/gene-expression-signatures-of-angiocidin-and-darapladib-treatment-connect-to-therapy-options-in-cervical-cancer
#13
Martin Koch, Michael Wiese
PURPOSE: To assign functional properties to gene expression profiles of cervical cancer stages and identify clinically relevant biomarker genes. EXPERIMENTAL DESIGN: Microarray samples of 24 normal and 102 cervical cancer biopsies from four publicly available studies were pooled and evaluated. High-quality microarrays were normalized using the CONOR package from the Bioconductor project. Gene expression profiling was performed using variance-component analysis for accessing most reliable probes, which were subsequently processed by gene set enrichment analysis...
February 2013: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/22826709/detrimental-effects-of-rat-mesenchymal-stromal-cell-pre-treatment-in-a-model-of-acute-kidney-rejection
#14
Martina Seifert, Meaghan Stolk, Dietrich Polenz, Hans-Dieter Volk
Mesenchymal stromal cells (MSC) have shown immunomodulatory and tissue repair potential including partial tolerance induction by pre-treatment of donor-specific cells in a rat heart transplantation model. Very recently, we could show that autologous MSC attenuated ischemia reperfusion injury in a highly mismatched donor-recipient rat kidney transplant model. Therefore, we investigated donor-specific MSC pre-treatment in this rat kidney transplantation model to study whether graft function could be improved, or if tolerance could be induced...
2012: Frontiers in Immunology
https://www.readbyqxmd.com/read/22609757/immunosuppression-with-4sc-101-a-novel-inhibitor-of-dihydroorotate-dehydrogenase-in-a-rat-model-of-renal-transplantation
#15
Krisztina Rusai, Christoph Schmaderer, Marcus Baumann, Stefan Chmielewski, Agnes Prókai, Eva Kis, Attila J Szabó, Johann Leban, Robert Doblhofer, Aldo Ammendola, Jens Lutz, Uwe Heemann
BACKGROUND: 4SC-101 is a novel dihydroorotate dehydrogenase inhibitor and a blocker of interleukin (IL)-17 secretion with beneficial effects in experimental lupus and inflammatory bowel disease. Its immunomodulatory effect on acute kidney rejection is not known; therefore, in this study, the impact of 4SC-101 was examined in a rat model of acute kidney rejection. METHODS: The kidneys of Brown-Norway rats were orthotopically transplanted into bilaterally nephrectomized Lewis recipients...
June 15, 2012: Transplantation
https://www.readbyqxmd.com/read/22470536/dr-high-cd45ra-tregs-potentially-affect-the-suppressive-activity-of-the-total-treg-pool-in-renal-transplant-patients
#16
Matthias Schaier, Nicole Seissler, Edgar Schmitt, Stefan Meuer, Friederike Hug, Martin Zeier, Andrea Steinborn
Recent studies show that regulatory T cells (Tregs) play an essential role in tolerance induction after organ transplantation. In order to examine whether there are differences in the composition of the total CD4(+)CD127(low+/-)FoxP3(+)- Treg cell pool between stable transplant patients and patients with biopsy proven rejection (BPR), we compared the percentages and the functional activity of the different Treg cell subsets (DR(high+)CD45RA(-)-Tregs, DR(low+)CD45RA(-)-Tregs, DR(-)CD45RA(-)-Tregs, DR(-)CD45RA(+)-Tregs)...
2012: PloS One
https://www.readbyqxmd.com/read/21812927/urinary-mir-210-as-a-mediator-of-acute-t-cell-mediated-rejection-in-renal-allograft-recipients
#17
J M Lorenzen, I Volkmann, J Fiedler, M Schmidt, I Scheffner, H Haller, W Gwinner, T Thum
MicroRNAs (miRNAs) are small ribonucleotides regulating gene expression. Circulating miRNAs are remarkably stable in the blood. We tested whether miRNAs are also detectable in urine and may serve as new predictors of outcome in renal transplant patients with acute rejection. We profiled urinary miRNAs of stable transplant patients and transplant patients with acute rejection. The miR-10a, miR-10b and miR-210 were strongly deregulated in urine of the patients with acute rejection. We confirmed these data in urine of a validation cohort of 62 patients with acute rejection, 19 control transplant patients without rejection and 13 stable transplant patients with urinary tract infection by quantitative RT-PCR...
October 2011: American Journal of Transplantation
https://www.readbyqxmd.com/read/21204904/the-relationship-between-interferon-%C3%AE-gene-polymorphism-and-acute-kidney-allograft-rejection
#18
L Zibar, J Wagner, D Pavlinić, J Galić, J Pasini, K Juras, J Barbić
Cytokine gene polymorphisms have been associated with modified gene expression and cytokine production. Gamma interferon (IFN-γ) plays an important role in the pathogenesis of kidney transplant rejection. This study evaluated the association between IFN-γ gene polymorphisms and the history of acute allograft rejection in 53 adult first-transplant recipients receiving cadaveric kidney grafts. They were followed up in a single centre until 2006, for a median time of 4 years after transplantation (1-22 years)...
April 2011: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/21094834/delayed-kidney-allograft-function-after-simultaneous-pancreas-kidney-transplantation
#19
E B Rangel, C S Melaragno, A M Gonzalez, M M Linhares, J R de Sá, A Salzedas, J O Medina-Pestana
BACKGROUND: Simultaneous pancreas-kidney transplantation (SPKT) is one of the treatments for insulin-dependent chronic renal failure patients. METHODS: One-year patient and kidney allograft survival rates of 150 patients undergoing SPKT were subjected to Cox regression and Kaplan-Meier analyses. Uni- and multivariate methods identified risk factors involved in allograft and patient survival. RESULTS: One-year patient and kidney allograft survival rates were 82% and 80%, respectively...
November 2010: Transplantation Proceedings
https://www.readbyqxmd.com/read/20463638/influence-of-preexisting-hepatitis-c-virus-antibody-positivity-in-simultaneous-pancreas-kidney-transplant-recipients
#20
Maria Miguel, Marcelo Santos Sampaio, Hung-Tien Kuo, Neda Poommipanit, Paul Martin, Suphamai Bunnapradist
BACKGROUND: Preexisting hepatitis C virus (HCV) infection is implicated in diminished patient and graft survivals in renal transplant recipients. The impact of HCV infection on patient and graft survival in simultaneous pancreas-kidney transplantations is unclear. We evaluated the effect of preexisting HCV infection on patient and graft survival in simultaneous pancreas-kidney transplant (SPKT) recipients in the United States. METHODS: Using the Organ Procurement and Transplant Network/United Network for Organ Sharing database as of March 2009, adult primary SPKT recipients transplanted from 1995 to 2008 were studied...
July 15, 2010: Transplantation
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