keyword
https://read.qxmd.com/read/38547334/noninvasive-assessment-of-liver-fibrosis-and-portal-hypertension
#1
JOURNAL ARTICLE
Andres Duarte-Rojo, Keyur Patel, Don C Rockey
PURPOSE OF REVIEW: The result of ongoing liver injury - and disease, regardless of cause - is fibrosis, and fibrosis appears to be a critically important result of ongoing injury. Further, in a number of different liver diseases, the presence of fibrosis has prognostic value. Therefore, the assessment of fibrosis is of critical clinical importance. Given the importance of fibrosis, there has been a rapid evolution in the use of noninvasive liver tests. This review highlights a number of the core principles surrounding...
March 29, 2024: Current Opinion in Gastroenterology
https://read.qxmd.com/read/38545074/computed-tomography-angiography-confirmed-aortic-in-stents-floating-thrombus-after-endovascular-stenting-a-retrospective-study
#2
JOURNAL ARTICLE
Lijie Zhang, Na Li, Xin Zhang, Xiaoqing Liu, Leqing Chen, Bin Liang, Wengang Sun, Heshui Shi
BACKGROUND: Aortic in-stents floating thrombus (ASFT) is a rare complication. The evolution of ASFT on computed tomography angiography (CTA) imaging and the treatment options remain under investigations. The aim of this study was to analyze the imaging manifestations of ASFT on CTA, and to explore safe and effective treatment options. METHODS: A retrospective, longitudinal study design was used. Clinical and imaging data were collected from patients with ASFT between January 2015 to December 2022 at the Union Hospital, Tongji Medical College, Huazhong University of Science and Technology...
March 15, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38543683/rare-plasmid-mediated-ampc-beta-lactamase-dha-1-located-on-easy-mobilized-is26-related-genetic-element-detected-in-escherichia-coli-from-livestock-and-food-in-germany
#3
JOURNAL ARTICLE
Chiara Manfreda, Annemarie Kaesbohrer, Silvia Schmoger, Tanja Skladnikiewicz-Ziemer, Mirjam Grobbel, Alexandra Irrgang
AmpC beta-lactamases cause resistance to third-generation cephalosporins, including beta-lactamase inhibitors. In Escherichia coli from the German food production chain, the majority of AmpC beta-lactamase activity can be attributed to plasmid-mediated CMY-2 or overproduction of chromosomal AmpC beta-lactamase, but occasionally other enzymes like DHA-1 are involved. This study investigated the prevalence of the AmpC beta-lactamase DHA-1 in ESBL/AmpC-producing E. coli ( n = 4706) collected between 2016 and 2021 as part of a German antimicrobial resistance monitoring program along the food chain...
March 21, 2024: Microorganisms
https://read.qxmd.com/read/38533040/comprehensive-single-cell-analysis-reveals-heterogeneity-of-fibroblast-subpopulations-in-ovarian-cancer-tissue-microenvironment
#4
JOURNAL ARTICLE
Bo Ding, Zheng Ye, Han Yin, Xin-Yi Hong, Song-Wei Feng, Jing-Yun Xu, Yang Shen
BACKGROUND: Ovarian cancer, as a highly malignant tumor, features the critical involvement of tumor-associated fibroblasts in the ovarian cancer tissue microenvironment. However, due to the apparent heterogeneity within fibroblast subpopulations, the specific functions of these subpopulations in the ovarian cancer tissue microenvironment remain insufficiently elucidated. METHODS: In this study, we integrated single-cell sequencing data from 32 ovarian cancer samples derived from four distinct cohorts and 3226 bulk RNA-seq data from GEO and TCGA-OV cohorts...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38531925/comparative-evaluation-of-non-invasive-tests-for-risk-stratification-for-cause-specific-mortality-in-at-risk-population-of-hepatic-fibrosis
#5
JOURNAL ARTICLE
Huiyul Park, Eileen L Yoon, Mimi Kim, Hye-Lin Kim, Mi Kyung Kim, Yu-Mi Kim, Dae Won Jun
Our study aimed to conduct a comparative evaluation of various noninvasive tests (NITs) for risk stratification in at-risk population for non-alcoholic fatty liver disease (NAFLD), focusing on cardiovascular and liver-related mortality. A total of 21,715 adults aged 40 years and older were enrolled at baseline. The mean follow-up period was 12.39 years. Three types of NITs (fibrosis-4 index [FIB-4], NAFLD fibrosis score [NFS], and steatosis-associated fibrosis estimator [SAFE] score) were used. When using the low cut-off as a 'rule-out' strategy, there were no significant differences in cardiovascular mortality between the 'rule-out' (low-risk) group and the 'rule-in' (intermediate- or high-risk) group based on FIB-4 (aHR = 1...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531877/ultrastructure-of-human-brain-tissue-vitrified-from-autopsy-revealed-by-cryo-et-with-cryo-plasma-fib-milling
#6
JOURNAL ARTICLE
Benjamin C Creekmore, Kathryn Kixmoeller, Ben E Black, Edward B Lee, Yi-Wei Chang
Ultrastructure of human brain tissue has traditionally been examined using electron microscopy (EM) following fixation, staining, and sectioning, which limit resolution and introduce artifacts. Alternatively, cryo-electron tomography (cryo-ET) allows higher resolution imaging of unfixed cellular samples while preserving architecture, but it requires samples to be vitreous and thin enough for transmission EM. Due to these requirements, cryo-ET has yet to be employed to investigate unfixed, never previously frozen human brain tissue...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531503/melanin-granules-morphology-and-distribution-in-human-black-hair-investigated-by-focused-ion-beam-scanning-electron-microscopy-differences-between-asian-and-caucasian-hair
#7
JOURNAL ARTICLE
Toru Kojima, Hiromi Yamada, Sakiko Enomoto, Tomoyo Nakao, Shigeo Arai
Melanin granules (melanosomes) in Asian and Caucasian black hairs were investigated by focused ion beam scanning electron microscopy (FIB-SEM). This technique facilitates a direct evaluation of the three-dimensional distribution and morphology of melanin granules without requiring their isolation from hair. Three-dimensional reconstructed images of melanin granule distribution in hair samples were obtained using serial SEM images observed by FIB-SEM. Melanin granules in black hair tended to be three-dimensionally dense in the outer periphery of the cortex...
March 24, 2024: Journal of Structural Biology
https://read.qxmd.com/read/38531177/dual-blockade-of-interleukin-17a-and-interleukin-17f-as-a-therapeutic-strategy-for-liver-fibrosis-investigating-the-potential-effect-and-mechanism-of-brodalumab
#8
JOURNAL ARTICLE
Kazuki M Matsuda, Hirohito Kotani, Teruyoshi Hisamoto, Ai Kuzumi, Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Shinichi Sato, Ayumi Yoshizaki
Liver fibrosis is a terminal manifestation of various chronic liver diseases. There are no drugs that can reverse the condition. Recently, the importance of interleukin-17 (IL17) in the pathophysiology has been revealed and has attracted attention as a therapeutic target. We aimed to reveal the roles of IL17A and IL17F in liver fibrosis, and to validate the potential of their dual blockade as therapeutic strategy. First, we retrospectively reviewed the longitudinal change of FIB-4 index, a clinical indicator of liver fibrosis, among psoriasis patients treated by brodalumab, which blocks IL17 receptor A (IL17RA)...
March 25, 2024: Cytokine
https://read.qxmd.com/read/38530817/steatotic-liver-disease-and-its-newly-proposed-sub-classifications-correlate-with-progression-of-the-coronary-artery-calcium-score
#9
JOURNAL ARTICLE
Aryoung Kim, Danbee Kang, Sung Chul Choi, Juhee Cho, Dong Hyun Sinn, Geum-Youn Gwak
BACKGROUND & AIMS: A new nomenclature, Steatotic Liver Disease (SLD), has been proposed by consensus with sub-classifications and requires evidence-based validation. We assessed whether the presence and severity of SLD, as well as its sub-classifications, are associated with the progression of coronary atherosclerosis. METHODS: This longitudinal cohort study included 13,811 adults who participated in repeated regular health screening examinations between January 1, 2004 and December 31, 2021 that included assessments of their coronary artery calcium (CAC) scores...
2024: PloS One
https://read.qxmd.com/read/38527437/liver-stiffness-determined-by-transient-elastography-is-a-simple-and-highly-accurate-predictor-for-presence-of-liver-cirrhosis-in-clinical-routine
#10
JOURNAL ARTICLE
Peter Lemmer, Lydia Christina Rohr, Marie Henning, Kerem Bulut, Paul Manka, Ali Canbay, Jan-Peter Sowa
INTRODUCTION: Early detection of patients with advanced chronic liver disease is critical for prevention of complications and inclusion in surveillance programs for hepatocellular carcinoma. In daily clinical care, it remains challenging to differentiate early cirrhosis from lower fibrosis grades without performing a liver biopsy. Aim of the present study was to assess performance of different non-invasive detection tools to differentiate cirrhosis from lower fibrosis grades. METHODS: Data of 116 patients (51 male, 65 female) with chronic liver disease of various origin undergoing liver biopsy was analysed...
March 25, 2024: Digestive Diseases
https://read.qxmd.com/read/38526872/multi-stimuli-operando-transmission-electron-microscopy-for-two-terminal-oxide-based-devices
#11
JOURNAL ARTICLE
Oscar Recalde-Benitez, Yevheniy Pivak, Robert Winkler, Tianshu Jiang, Esmaeil Adabifiroozjaei, H Hugo Perez-Garza, Leopoldo Molina-Luna
The integration of microelectromechanical systems (MEMS)-based chips for in situ transmission electron microscopy (TEM) has emerged as a highly promising technique in the study of nanoelectronic devices within their operational parameters. This innovative approach facilitates the comprehensive exploration of electrical properties resulting from the simultaneous exposure of these devices to a diverse range of stimuli. However, the control of each individual stimulus within the confined environment of an electron microscope is challenging...
March 25, 2024: Microscopy and Microanalysis
https://read.qxmd.com/read/38525890/indirect-correlative-light-and-electron-microscopy-iclem-a-novel-pipeline-for-multiscale-quantification-of-structure-from-molecules-to-organs
#12
JOURNAL ARTICLE
Heather L Struckman, Nicolae Moise, Bieke Vanslembrouck, Nathan Rothacker, Zhenhui Chen, Jolanda van Hengel, Seth H Weinberg, Rengasayee Veeraraghavan
Correlative light and electron microscopy (CLEM) methods are powerful methods that combine molecular organization (from light microscopy) with ultrastructure (from electron microscopy). However, CLEM methods pose high cost/difficulty barriers to entry and have very low experimental throughput. Therefore, we have developed an indirect correlative light and electron microscopy (iCLEM) pipeline to sidestep the rate-limiting steps of CLEM (i.e., preparing and imaging the same samples on multiple microscopes) and correlate multiscale structural data gleaned from separate samples imaged using different modalities by exploiting biological structures identifiable by both light and electron microscopy as intrinsic fiducials...
March 25, 2024: Microscopy and Microanalysis
https://read.qxmd.com/read/38523735/risk-factors-for-development-of-cirrhosis-in-chronic-viral-hepatitis-b-patients-who-had-persistent-viral-suppression-with-antiviral-therapy
#13
JOURNAL ARTICLE
Soe T Maung, Pakanat Decharatanachart, Sombat Treeprasertsuk, Roongruedee Chaiteerakij
BACKGROUND AND AIMS: Chronic viral hepatitis B (CHB)-infected patients occasionally develop cirrhosis despite having persistent viral suppression with antiviral therapy. We aimed to identify risk factors for developing cirrhosis in hepatitis B virus (HBV)-suppressed patients. METHODS: We conducted a case-control study involving 120 noncirrhotic CHB-infected patients achieving viral suppression with antiviral treatment, with 40 cases developing cirrhosis and 80 age-, sex-, and Fibrosis-4 (FIB-4)-matched controls...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38522962/stage-of-fibrosis-is-not-a-predictive-determinant-of-weight-loss-in-patients-undergoing-bariatric-surgery
#14
JOURNAL ARTICLE
Maximilian Joseph Brol, Uta Drebber, Xiaojie Yu, Robert Schierwagen, Wenyi Gu, Andreas Plamper, Sabine Klein, Margarete Odenthal, Frank Erhard Uschner, Michael Praktiknjo, Jonel Trebicka, Karl Peter Rheinwalt
BACKGROUND: Obesity and nonalcoholic fatty liver disease (NAFLD) are an increasing health care burden worldwide. Weight loss is currently the best option to alleviate NAFLD and is efficiently achieved by bariatric surgery. Presence of NAFLD seems to be predictive for postoperative weight loss. To date, only few predictive factors for postbariatric weight loss (age, diabetes, psychiatric disorders) are established. OBJECTIVES: Since liver fibrosis is the pathogenic driver for the progression of liver disease, we investigated its role in predicting postoperative weight loss...
February 24, 2024: Surgery for Obesity and Related Diseases
https://read.qxmd.com/read/38521512/development-and-validation-of-an-assessment-tool-for-adult-simulated-ultrasound-guided-fascia-iliaca-block-a-prospective-monocentric-study
#15
JOURNAL ARTICLE
Frederic-Pierre Guyader, Mathieu Violeau, Jérémy Guenezan, Youcef Guechi, Cyril Breque, Pauline Betoulle-Masset, Jean-Pierre Faure, Denis Oriot, Daniel Aiham Ghazali
BACKGROUND: Fascia iliaca block (FIB) is an effective technique for analgesia. While FIB using ultrasound is preferred, there is no current standardised training technique or assessment scale. We aimed to create a valid and reliable tool to assess ultrasound-guided FIB. METHOD: This prospective observational study was conducted in the ABS-Lab simulation centre, University of Poitiers, France between 26-29 October and 14-17 December 2021. Psychometric testing included validity analysis and reliability between two independent observers...
March 23, 2024: Emergency Medicine Journal: EMJ
https://read.qxmd.com/read/38520807/chronic-exposure-to-ambient-air-pollution-and-the-risk-of-non-alcoholic-fatty-liver-disease-a-cross-sectional-study-in-taiwan-and-hong-kong
#16
JOURNAL ARTICLE
Yacong Bo, Changqing Lin, Cui Guo, Martin Wong, Bo Huang, Alexis Lau, Yu Huang, Xiang Qian Lao
BACKGROUND: Information on the relation of air pollution with non-alcoholic fatty liver disease (NAFLD) is scarce. We thus conducted a large cross-sectional study in Asia to investigate the role of air pollution in NAFLD. METHODS: We recruited 329,048 adults (mean age: 41.0 years) without other liver disease (hepatitis and cirrhosis) or excessive alcohol consumption in Taiwan and Hong Kong from 2001 to 2018. The concentrations of nitrogen dioxide (NO2 ) and ozone (O3 ) were estimated using a space-time regression model, and the concentrations of fine particulate matter (PM2...
March 21, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38518161/impact-of-combined-nifedipine-and-aspirin-therapy-on-hemodynamics-in-patients-with-early-eclampsia
#17
JOURNAL ARTICLE
Jinyu Fan, Yujiao Yang, Xiumei Wang
BACKGROUND: Preeclampsia poses substantial risks during pregnancy. Exploring innovative treatment approaches like the combination of Nifedipine and aspirin is crucial for improving maternal and fetal outcomes. OBJECTIVE: This study aims to assess the efficacy of nifedipine and aspirin tablets in treating preeclampsia and their impact on blood rheology and coagulation. METHODS: We selected 96 pregnant patients with preeclampsia treated at our hospital between January 2020 and January 2022...
March 22, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38517922/single-cell-analysis-reveals-landscape-of-endometrial-cancer-response-to-estrogen-and-identification-of-early-diagnostic-markers
#18
JOURNAL ARTICLE
Chunli Dong, Liyan Zhao, Xiongtao Liu, Ling Dang, Xin Zhang
BACKGROUND: The development of endometrial cancer (EC) is closely related to the abnormal activation of the estrogen signaling pathway. Effective diagnostic markers are important for the early detection and treatment of EC. METHOD: We downloaded single-cell RNA sequencing (scRNA-seq) and spatial transcriptome (ST) data of EC from public databases. Enrichment scores were calculated for EC cell subpopulations using the "AddModuleScore" function and the AUCell package, respectively...
2024: PloS One
https://read.qxmd.com/read/38515952/red-cell-distribution-width-platelet-ratio-estimates-the-3-year-risk-of-decompensation-in-metabolic-dysfunction-associated-steatotic-liver-disease-induced-cirrhosis
#19
JOURNAL ARTICLE
Marcello Dallio, Mario Romeo, Paolo Vaia, Salvatore Auletta, Simone Mammone, Marina Cipullo, Luigi Sapio, Angela Ragone, Marco Niosi, Silvio Naviglio, Alessandro Federico
BACKGROUND: For compensated advanced chronic liver disease (cACLD) patients, the first decompensation represents a dramatically worsening prognostic event. Based on the first decompensation event (DE), the transition to decompensated advanced chronic liver disease (dACLD) can occur through two modalities referred to as acute decompensation (AD) and non-AD (NAD), respectively. Clinically Significant Portal Hypertension (CSPH) is considered the strongest predictor of decompensation in these patients...
February 21, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38514842/advanced-liver-fibrosis-is-associated-with-decreased-gait-speed-in-older-patients-with-chronic-liver-disease
#20
JOURNAL ARTICLE
Kenichi Fudeyasu, Kai Ushio, Takuo Nomura, Toshihiro Kawae, Daisuke Iwaki, Yuki Nakashima, Akiko Nagao, Akira Hiramatsu, Eisuke Murakami, Shiro Oka, Yukio Mikami
This study investigated whether the progression of liver fibrosis affects the prevalence of sarcopenia and incidence of decreased gait speed in older patients with chronic liver disease (CLD). Patients with CLD aged ≥ 60 years were classified into low, intermediate, and high fibrosis 4 (FIB-4) index groups according to the degree of liver fibrosis. The prevalence of sarcopenia and incidence of decreased gait speed (< 1.0 m/s) were compared among the three groups. Logistic regression analysis was performed to investigate factors affecting the risk of decreased gait speed...
March 21, 2024: Scientific Reports
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