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https://www.readbyqxmd.com/read/27920479/ceruloplasmin-a-reliable-marker-of-fibrosis-in-chronic-hepatitis-b-virus-patients-with-normal-or-minimally-raised-alanine-aminotransferase
#1
Da-Wu Zeng, Jing Dong, Jia-Ji Jiang, Yue-Yong Zhu, Yu-Rui Liu
AIM: To develop a non-invasive model to evaluate significant fibrosis and cirrhosis by investigating the association between serum ceruloplasmin (CP) levels and liver fibrosis in chronic hepatitis B (CHB) patients with normal or minimally raised alanine aminotransferase (ALT). METHODS: Serum samples and liver biopsy were obtained from 193 CHB patients with minimally raised or normal ALT who were randomly divided into a training group (n = 97) and a validation group (n = 96)...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27918627/exploring-dynamic-surface-processes-during-silicate-mineral-wollastonite-dissolution-with-liquid-cell-tem
#2
D N Leonard, R Hellmann
Most liquid cell transmission electron microscopy (LC TEM) studies focus on nanoparticles or nanowires, in large part because the preparation and study of materials in this size range is straightforward. By contrast, this is not true for samples in the micrometre size range, in large part because of the difficulties associated with sample preparation starting from a 'bulk' material. There are also many advantages inherent to the study of micrometre-sized samples compared to their nanometre-sized counterparts...
December 5, 2016: Journal of Microscopy
https://www.readbyqxmd.com/read/27906052/antibody-responses-to-de-novo-identified-citrullinated-fibrinogen-peptides-in-rheumatoid-arthritis-and-visualization-of-the-corresponding-b-cells
#3
Vijay Joshua, Loes Schobers, Philip J Titcombe, Lena Israelsson, Johan Rönnelid, Monika Hansson, Anca I Catrina, Ger J M Pruijn, Vivianne Malmström
BACKGROUND: Antibodies against citrullinated proteins (ACPA) are common in patients with rheumatoid arthritis (RA). ACPA can appear before disease onset and target many self-antigens. Citrullinated fibrin/fibrinogen represents a classical ACPA target antigen, and mass spectrometry of RA synovial fluid reveals elevated citrullinated (cit) fibrinogen (Fib) peptides compared to non-RA controls. We investigated the extent to which these less-studied peptides represent autoantibody targets and sought to visualize the corresponding cit-Fib-reactive B cells in RA patients...
December 1, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27898297/a-novel-pfib-sample-preparation-protocol-for-correlative-3d-x-ray-cnt-and-fib-tof-sims-tomography
#4
Agnieszka Priebe, Guillaume Audoit, Jean-Paul Barnes
We present a novel sample preparation method that allows correlative 3D X-ray Computed Nano-Tomography (CNT) and Focused Ion Beam Time-Of-Flight Secondary Ion Mass Spectrometry (FIB-TOF-SIMS) tomography to be performed on the same sample. In addition, our invention ensures that samples stay unmodified structurally and chemically between the subsequent experiments. The main principle is based on modifying the topography of the X-ray CNT experimental setup before FIB-TOF-SIMS measurements by incorporating a square washer around the sample...
November 19, 2016: Ultramicroscopy
https://www.readbyqxmd.com/read/27897323/prognostic-durability-of-liver-fibrosis-tests-and-improvement-in-predictive-performance-for-mortality-by-combining-tests
#5
Sandrine Bertrais, Jérôme Boursier, Alexandra Ducancelle, Frédéric Oberti, Isabelle Fouchard-Hubert, Valérie Moal, Paul Calès
BACKGROUND AND AIM: There is currently no recommended time interval between non-invasive fibrosis measurements for monitoring chronic liver diseases. We determined how long a single liver fibrosis evaluation may accurately predict mortality, and assessed whether combining tests improves prognostic performance. METHODS: We included 1559 patients with chronic liver disease and available baseline liver stiffness measurement (LSM) by Fibroscan, APRI, FIB-4, Hepascore, and FibroMeter(V2G) ...
November 29, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27896288/ultrastructure-of-early-amelogenesis-in-wild-type-amelx-and-enam-mice-enamel-ribbon-initiation-on-dentin-mineral-and-ribbon-orientation-by-ameloblasts
#6
Charles E Smith, Yuanyuan Hu, Jan C-C Hu, James P Simmer
INTRODUCTION: Dental enamel is comprised of highly organized, oriented apatite crystals, but how they form is unclear. METHODS: We used focused ion beam (FIB) scanning electron microscopy (SEM) to investigate early enamel formation in 7-week-old incisors from wild-type, Amelx(-/-), and Enam(-/-) C56BL/6 mice. FIB surface imaging scans thicker samples so that the thin enamel ribbons do not pass as readily out of the plane of section, and generates serial images by a mill and view approach for computerized tomography...
November 2016: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/27881882/depletion-region-surface-effects-in-electron-beam-induced-current-measurements
#7
Paul M Haney, Heayoung P Yoon, Benoit Gaury, Nikolai B Zhitenev
Electron beam induced current (EBIC) is a powerful characterization technique which offers the high spatial resolution needed to study polycrystalline solar cells. Current models of EBIC assume that excitations in the p-n junction depletion region result in perfect charge collection efficiency. However we find that in CdTe and Si samples prepared by focused ion beam (FIB) milling, there is a reduced and nonuniform EBIC lineshape for excitations in the depletion region. Motivated by this, we present a model of the EBIC response for excitations in the depletion region which includes the effects of surface recombination from both charge-neutral and charged surfaces...
September 7, 2016: Journal of Applied Physics
https://www.readbyqxmd.com/read/27875352/does-incorporating-change-in-apri-or-fib-4-indices-over-time-improve-the-accuracy-of-a-single-index-for-identifying-liver-fibrosis-in-persons-with-chronic-hepatitis-c-virus-infection
#8
Prabhu P Gounder, Celia Haering, Dana J T Bruden, Lisa Townshend-Bulson, Brenna C Simons, Philip R Spradling, Brian J McMahon
BACKGROUND: The aspartate aminotransferase-to-platelet ratio index (APRI) and a fibrosis index calculated using platelets (FIB-4) have been proposed as noninvasive markers of liver fibrosis. GOALS: To determine APRI/FIB-4 accuracy for predicting histologic liver fibrosis and evaluate whether incorporating change in index improves test accuracy in hepatitis C virus (HCV)-infected Alaska Native persons. STUDY: Using liver histology as the gold standard, we determined the test characteristics of APRI to predict Metavir ≥F2 fibrosis and FIB-4 to predict Metavir ≥F3 fibrosis...
November 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27871553/fascia-iliaca-block-associated-only-with-deep-sedation-in-high-risk-patients-taking-p2y12-receptor-inhibitors-for-intramedullary-femoral-fixation-in-intertrochanteric-hip-fracture-a-series-of-3-cases
#9
Carlos Rodrigues Almeida, Emília Milheiro Francisco, Vítor Pinho-Oliveira, José Pedro Assunção
OBJECTIVE: We present a series of 3 cases in which the impact in outcome was, first of all, related to the capacity to offer early and safer treatment to some hip fracture high-risk patients using a fascia iliaca block (FIB; ropivacaine 0,5% 20 cc and mepivacaine 1,3% 15 cc, given 30 minutes before incision) associated only with deep sedation, contributing to better practice and outcome. CASE REPORTS: All elderly patients were American Society of Anesthesiologists IV patients, under P2Y12 receptor inhibitors, suffering from an intertrochanteric fracture, and purposed for intramedullary femoral fixation (IMF)...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27869059/site-specific-preparation-of-intact-solid-liquid-interfaces-by-label-free-in-situ-localization-and-cryo-focused-ion-beam-lift-out
#10
Michael J Zachman, Emily Asenath-Smith, Lara A Estroff, Lena F Kourkoutis
Scanning transmission electron microscopy (STEM) allows atomic scale characterization of solid-solid interfaces, but has seen limited applications to solid-liquid interfaces due to the volatility of liquids in the microscope vacuum. Although cryo-electron microscopy is routinely used to characterize hydrated samples stabilized by rapid freezing, sample thinning is required to access the internal interfaces of thicker specimens. Here, we adapt cryo-focused ion beam (FIB) "lift-out," a technique recently developed for biological specimens, to prepare intact internal solid-liquid interfaces for high-resolution structural and chemical analysis by cryo-STEM...
November 21, 2016: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/27866724/spatial-and-temporal-microbial-pollution-patterns-in-a-tropical-estuary-during-high-and-low-river-flow-conditions
#11
T N Wiegner, C J Edens, L M Abaya, K M Carlson, A Lyon-Colbert, S L Molloy
Spatial and temporal patterns of coastal microbial pollution are not well documented. Our study examined these patterns through measurements of fecal indicator bacteria (FIB), nutrients, and physiochemical parameters in Hilo Bay, Hawai'i, during high and low river flow. >40% of samples tested positive for the human-associated Bacteroides marker, with highest percentages near rivers. Other FIB were also higher near rivers, but only Clostridium perfringens concentrations were related to discharge. During storms, FIB concentrations were three times to an order of magnitude higher, and increased with decreasing salinity and water temperature, and increasing turbidity...
November 17, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27859587/gamma-glutamyl-transpeptidase-to-platelet-ratio-is-an-independent-predictor-of-hepatitis-b-virus-related-liver-cancer
#12
Yong Eun Park, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Sojung Han, Mi Young Jeon, Ja Yoon Heo, Kijun Song, Seung Up Kim
BACKGROUND AND AIMS: Gamma-glutamyl transpeptidase-to-platelet ratio (GPR) can evaluate the degree of liver fibrosis. We investigated whether GPR can predict the development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. METHODS: We retrospectively evaluated 1,109 CHB patients that were enrolled between 2006 and 2012, and all patients had available data for the assessment of GPR at enrollment. Three risk groups were defined according to tertile stratification: GPR < 0...
November 16, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27859583/external-validation-of-the-nonalcoholic-fatty-liver-disease-fibrosis-score-for-assessing-advanced-fibrosis-in-korean-patients
#13
Dae Won Jun, Sang Gyune Kim, Sang Hoon Park, So-Young Jin, Ji Sung Lee, Jin-Woo Lee, Moon Young Kim, Dae Hee Choi, Yong Kyun Cho, Jong Eun Yeon, Joo Hyun Sohn
BACKGROUND: The degree of liver fibrosis in non-alcoholic fatty liver disease (NAFLD) is a critical predictive factor for patient prognosis. This study was intended to perform external validation of the various fibrosis prediction models for assessing advanced fibrosis in Korean NAFLD patients. METHODS: A retrospective study of 412 patients with NAFLD confirmed by liver biopsy in hospitals affiliated with the Koran NAFLD study group was conducted and the predictive ability of existing liver fibrosis prediction models including NAFLD fibrosis score (NFS), BARD, and FIB-4 were compared...
November 11, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27856044/community-fecal-carriage-of-broad-spectrum-cephalosporin-resistant-escherichia-coli-in-tunisian-children
#14
Sana Ferjani, Mabrouka Saidani, Zeineb Hamzaoui, Carla Andrea Alonso, Carmen Torres, Elaa Maamar, Amine Faouzi Slim, Ben Boubaker Ilhem Boutiba
The spread of extended spectrum β-lactamases (ESBL) and plasmid mediated AmpC β-lactamases (pAmpC) was evaluated in Escherichia coli strains collected from the intestinal microbiota of healthy children in Tunisia. The carriage rate of CTX(R)E. coli was 6.6% (7 of 105 samples) and one strain/sample was further characterized (7 isolates). These isolates harbored blaCTX-M-1 (n = 4), blaCTX-M-15 (n = 2), and blaCMY-2 gene (n = 1), which were usually located on FIB replicon type and carried class 1 integrons. The acc(6')-Ib-cr variant was identified in one isolate that harbored blaCTX-M-15...
March 8, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27855952/decay-of-sewage-sourced-microbial-source-tracking-markers-and-fecal-indicator-bacteria-in-marine-waters
#15
Mia Catharine Mattioli, Lauren M Sassoubre, Todd L Russell, Alexandria B Boehm
The decay of sewage-sourced enterococci, Escherichia coli, three human-associated microbial source tracking (MST) markers, Salmonella, Campylobacter, and norovirus GII was measured in situ in coastal, marine waters. Experiments examined the effects of sunlight intensity and season on decay. Seawater was seeded with untreated sewage, placed into permeable dialysis bags, and deployed in the coastal ocean near the water surface, and at 18 cm, and 99 cm depths, to vary solar intensity, during winter and summer seasons...
January 1, 2017: Water Research
https://www.readbyqxmd.com/read/27852408/-study-on-the-difference-of-blood-coagulation-function-in-patients-with-traumatic-brain-injury-in-plain-and-plateau-area
#16
J Sun, Y Tian, R C Jiang, X L Dong, Y Wang, W B Wu, K X Wu, J N Zhang
Objective: In this study, we tested platelet count (PC), prothrombin time (PT), activated partial thromboplastin time (APTT), and other indicators of coagulation function, and revealed their difference in patients with traumatic brain injury (TBI) between plain and plateau area. Base on the results, we may provide research basis for the therapy of TBI associated coagulopathy in different areas. Methods: 151 TBI patients from Tianjin Medical University General Hospital, and 74 from People's Hospital of Tibet Autonomous Region in the period from Dec 2013 to Dec 2015 were enrolled...
October 25, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27834312/atomic-layer-deposition-ultrathin-film-origami-using-focused-ion-beams
#17
O D Supekar, J J Brown, N T Eigenfeld, J C Gertsch, V M Bright
Focused ion beam (FIB) micromachining is a powerful tool for maskless lithography and in recent years FIB has been explored as a tool for strain engineering. Ion beam induced deformation can be utilized as a means for folding freestanding thin films into complex 3D structures. FIB of high energy gallium (Ga(+)) ions induces stress by generation of dislocations and ion implantation within material layers, which create creases or folds upon mechanical relaxation enabled by motion of the material layers. One limitation on such processing is the ability to fabricate flat freestanding thin film structures...
December 9, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27828370/annealing-effects-on-microstructure-and-laser-induced-damage-threshold-of-quasi-rugate-filters
#18
Yunti Pu, Ping Ma, Zhao Qiao, Mingxiao Zhang, Zhongwen Lu, Fuming Qiu, Liang Lv
Ta<sub>2</sub>O<sub>5</sub>/SiO<sub>2</sub> quasi-rugate filters with high damage thresholds were deposited by ion-beam sputtering and then annealed at temperature of 200-800°C. The relations between microstructure, optical properties, chemical composition, weak absorption, and laser-induced damage threshold (LIDT) were studied. It was found that the transmittance spectra shifted to short wavelength as the annealing temperature increased. Three evolution courses of the films in the annealing process were analyzed by Atomic Force microscopy (AFM), Zygo interferometer measurement and Focused Ion Beam microscope (FIB)...
October 3, 2016: Optics Express
https://www.readbyqxmd.com/read/27822295/infection-with-hepatitis-viruses-fib-4-index-and-risk-of-hepatocellular-carcinoma-in-southern-italy-a-population-based-cohort-study
#19
Mario Fusco, Pierluca Piselli, Saverio Virdone, Pietro Di Cicco, Paola Scognamiglio, Paolo De Paoli, Valerio Ciullo, Diana Verdirosi, Michele D'Orazio, Luigino Dal Maso, Enrico Girardi, Silvia Franceschi, Diego Serraino
BACKGROUND: The incidence of hepatocellular carcinoma (HCC) and its association with hepatitis C (HCV) and hepatitis B virus (HBV) infections, FIB-4 index and liver enzymes was assessed in an area of the province of Naples covered by a population-based cancer registry. METHODS: We conducted a cohort investigation on 4492 individuals previously enrolled in a population-based seroprevalent survey on HCV and HBV infections. The diagnosis of HCC was assessed through a record linkage with the cancer registry...
2016: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/27813162/do-directly-acting-antiviral-agents-for-hcv-increase-the-risk-of-hepatic-decompensation-and-decline-in-renal-function-results-from-erchives
#20
A A Butt, Y Ren, K Marks, O S Shaikh, K E Sherman
BACKGROUND: Directly acting antiviral agents (DAA) have been associated with hepatic decompensation, especially in patients with pre-treatment cirrhosis, but this risk is not well defined. AIM: To determine the incidence of hepatic decompensation, liver transplantation, death and worsening renal function in patients treated with a Paritaprevir/ritonavir, Ombitasvir, Dasabuvir (PrOD), sofosbuvir/simeprevir or sofosbuvir/ledipasvir regimen. METHODS: We followed ERCHIVES participants treated with the above regimens for up to 12 weeks post-treatment...
January 2017: Alimentary Pharmacology & Therapeutics
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