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Bejan Aresh, Christiane Peuckert
The goal of this protocol is to describe a method for the dissection, isolation, and culture of mouse metanephric rudiments. During mammalian kidney development, the two progenitor tissues, the ureteric bud and the metanephric mesenchyme, communicate and reciprocally induce cellular mechanisms to eventually form the collecting system and the nephrons of the kidney. As mammalian embryos grow intrauterine and therefore are inaccessible to the observer, an organ culture has been developed. With this method, it is possible to study epithelial-mesenchymal interactions and cellular behavior during kidney organogenesis...
May 17, 2017: Journal of Visualized Experiments: JoVE
Bejan Aresh, Fabio B Freitag, Sharn Perry, Edda Blümel, Joey Lau, Marina C M Franck, Malin C Lagerström
Itch is a sensation that promotes the desire to scratch, which can be evoked by mechanical and chemical stimuli. In the spinal cord, neurons expressing the gastrin-releasing peptide receptor (GRPR) have been identified as specific mediators of itch. However, our understanding of the GRPR population in the spinal cord, and thus how these neurons exercise their functions, is limited. For this purpose, we constructed a Cre line designed to target the GRPR population of neurons (Grpr-Cre). Our analysis revealed that Grpr-Cre cells in the spinal cord are predominantly excitatory interneurons that are found in the dorsal lamina, especially in laminae II-IV...
May 2017: Pain
Aresh Sahu, Ritabrata Ghosh, Girish Deshpande, Mohit Prasad
Intercellular communication mediated by gap junction (GJ) proteins is indispensable during embryogenesis, tissue regeneration and wound healing. Here we report functional analysis of a gap junction protein, Innexin 2 (Inx2), in cell type specification during Drosophila oogenesis. Our data reveal a novel involvement of Inx2 in the specification of Border Cells (BCs), a migratory cell type, whose identity is determined by the cell autonomous STAT activity. We show that Inx2 influences BC fate specification by modulating STAT activity via Domeless receptor endocytosis...
January 2017: PLoS Genetics
Ying Liu, Yan Xia, Armin Tahmasbi Rad, Wafa Aresh, Mu-Ping Nieh
Bicellar mixtures have been used as alignable membrane substrates for the structural characterization of membrane-associated proteins. Most recently, it has been shown that bicelles can serve as nanocarriers to effectively deliver hydrophobic molecules to cancer cells with a 3- to 10-fold enhancement compared to that of chemically identical liposomes. In this chapter, a detailed preparation protocol, common structural characterization methods, the structural stability and the cellular uptake of bicellar nanodisks are discussed...
2017: Methods in Molecular Biology
Christiane Peuckert, Bejan Aresh, Pavlo Holenya, Derek Adams, Smitha Sreedharan, Annika Porthin, Louise Andersson, Hanna Pettersson, Stefan Wölfl, Rüdiger Klein, Leif Oxburgh, Klas Kullander
A substantial portion of the human population is affected by urogenital birth defects resulting from a failure in ureter development. Although recent research suggests roles for several genes in facilitating the ureter/bladder connection, the underlying molecular mechanisms remain poorly understood. Signaling via Eph receptor tyrosine kinases is involved in several developmental processes. Here we report that impaired Eph/Ephrin signaling in genetically modified mice results in severe hydronephrosis caused by defective ureteric bud induction, ureter maturation, and translocation...
August 2016: Kidney International
Alexander Aresh Azizi
Tobacco use in China is a substantial threat to global health and, after many years of poor implementation of tobacco control, attitudes are changing for the better and substantial actions may be about to follow. This commentary reviews the impact of tobacco and the recent history of tobacco control in China, the context and implications of new encouraging legislation.
June 22, 2016: Global Health Promotion
Abhijit Nadkarni, Paige Endsley, Urvita Bhatia, Daniela C Fuhr, Aneesa Noorani, Aresh Naik, Pratima Murthy, Richard Velleman
ISSUES: Despite the potential advantages of community detoxification for alcohol dependence, in many countries the available resources are mostly focused on specialist services that are resource-intensive, and often difficult to access because of financial or geographical factors. The aim of this systematic review is to synthesise the existing literature about the management of alcohol detoxification in the community to examine its effectiveness, safety, acceptability and feasibility...
May 2017: Drug and Alcohol Review
Behrooz Hamzeh, Farid Najafi, Behzad Karamimatin, Tuoraj Ahmadijouybari, Aresh Salari, Mehdi Moradinazar
PURPOSE: In Iran, the most common cause of injuries and the second leading cause of deaths are traffic accidents, and those problems impose a substantial financial burden on the society. This study aims to determine traffic accident mortality trends and their epidemiologic characteristics in the Kermanshah province, west of Iran. METHODS: In a cross sectional study, road traffic fatality data from 2004 to 2013 were analyzed to determine the epidemiological pattern of traffic accident mortality...
April 1, 2016: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
Abhijit Nadkarni, Helen A Weiss, Aresh Naik, Bhargav Bhat, Vikram Patel
BACKGROUND: Despite the large and growing public health problem of alcohol use disorders (AUD) in India there is a dearth of evidence about the longitudinal outcomes in AUD. The aim of this study is to describe the course and outcomes of AUD in a population based sample of men in India. METHODS: A community cohort of 1899 adult (18-49 years at baseline) men who participated in a cross-sectional survey in Goa, India between 2006 and 08, were re-interviewed face to face 6 years later (2012-14)...
May 1, 2016: Drug and Alcohol Dependence
Katarzyna Rogoz, Bejan Aresh, Fabio Batista Freitag, Hanna Pettersson, Elín Ingibjörg Magnúsdóttir, Linn Larsson Ingwall, Helena Haddadi Andersen, Marina Christina Mikaela Franck, Chetan Nagaraja, Klas Kullander, Malin Charlotta Lagerström
Allergic reactions can in severe cases induce a state of circulatory shock referred to as anaphylaxis. Histamine, the primary mediator of this condition, is released from immune cells, and, therefore, anaphylaxis has so far been considered an immune system disorder. However, we here show that the glutamatergic receptor mGluR7, expressed on a subpopulation of both peripheral and spinal cord neurons, controls histamine-induced communication through calcium-dependent autoinhibition with implications for anaphylaxis...
January 12, 2016: Cell Reports
Nirav K Patel, Sanjeeve Sabharwal, Christopher R Gooding, Aresh Hashemi-Nejad, Deborah M Eastwood
PURPOSE: Proximal femoral excision is a salvage procedure for painful chronic hip dislocation in cerebral palsy (CP) patients. The primary objective of this article is to describe our experience of an amplified interposition myoplasty, with appropriate peri-operative pain and tone management strategies, in a cohort of non-ambulatory CP patients with painful chronic hip dislocation. Our secondary objective is to present the clinical outcomes of these patients. METHODS: We describe our experience in 20 CP patients (25 procedures) at mean 54-month (range 27-169) follow-up with a surgical technique that includes an augmented interposition myoplasty and tone management...
August 2015: Journal of Children's Orthopaedics
Thomas Beggs, Aresh Sepehri, Andrea Szwajcer, Navdeep Tangri, Rakesh C Arora
BACKGROUND: Frailty has no single universally accepted definition or method for assessment. It is commonly defined from a physiological perspective as a disruption of homeostatic mechanisms ultimately leading to a vulnerable state. Numerous scoring indices and assessments exist to assist clinicians in determining the frailty status of a patient. The purpose of this review is to discuss the relationship between frailty and perioperative outcomes in surgical patients. PRINCIPAL FINDINGS: We performed a review to determine the association of frailty with perioperative outcomes in patients undergoing a wide variety of surgical procedures...
February 2015: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
Mathew David Sewell, Amanjot Chahal, Nawfal Al-Hadithy, Gordon W Blunn, Sean Molloy, Aresh Hashemi-Nejad
The skeletal dysplasias are a large, heterogeneous group of genetic disorders characterised by abnormal growth, development and remodelling of the bones and cartilage that comprise the human skeleton. They typically present with disproportionate short stature in childhood, or premature osteoarthritis in adulthood. The latest classification lists 456 disorders under 40 group headings differentiated by specific clinical, radiographic and molecular criteria. Establishing an accurate diagnosis is important to predict final height, expected complications and treatment, and for specific genetic and psychological counselling...
2015: Journal of Back and Musculoskeletal Rehabilitation
Aresh Sepehri, Thomas Beggs, Ansar Hassan, Claudio Rigatto, Christine Shaw-Daigle, Navdeep Tangri, Rakesh C Arora
OBJECTIVE: Current preoperative assessments for cardiac surgery, such as the European System for Cardiac Operative Risk Evaluation II and the Society of Thoracic Surgeons risk score, are limited in their ability to predict postoperative outcomes. This is thought to be due to the reliance on chronological age as a predictor of health. In geriatrics, frailty assessments have been developed as a tool in determining physiologic functioning capacity. Whether or not frailty predicts postoperative outcomes independent of existing cardiac preoperative risk scores remains unknown...
December 2014: Journal of Thoracic and Cardiovascular Surgery
Paul Whittingham-Jones, Nirav K Patel, Aresh Hashemi-Nejad
No abstract text is available yet for this article.
May 2014: Journal of Children's Orthopaedics
Paul Whittingham-Jones, Nirav Kirit Patel, Aresh Hashemi-Nejad
INTRODUCTION: A modification of the technique for performing the Bernese periacetabular osteotomy is described. MATERIALS AND METHODS: A medial approach to the Ischium and a subtle re-orientation of the pubic osteotomy are detailed. CONCLUSION: Surgical morbidity is likely decreased with a concurrent cosmetic advantage without compromise to surgical correction or patient safety.
March 2013: Journal of Children's Orthopaedics
Francois Tudor, Amir Ariamanesh, Anish Potty, Aresh Hashemi-Nejad
BACKGROUND: Management of the degenerate hip in patients with neuromuscular conditions should be aimed at improving quality of life and ease of nursing care. Arthroplasty poses a significant challenge with predisposition to dislocation and loosening due to anatomical abnormalities, soft tissue contractures and impaired muscle tone. METHODS: We present a series of 11 hips (9 patients) following total hip resurfacing arthroplasty for painful osteoarthritis in patients with differing neuromuscular conditions...
2013: Journal of Orthopaedics
Neil Segaren, Hani B Abdul-Jabar, Nicholas Segaren, Aresh Hashemi-Nejad
Idiopathic chondrolysis of the hip is a rare disorder characterized by pain, stiffness, limp and radiological loss of joint space of the affected hip. The clinical outcome varies from complete recovery to fibrous ankylosis. Management remains controversial. We aim to outline the natural history and pathology of the disease and treatment strategies.
March 2014: Journal of Pediatric Orthopedics. Part B
Hesham Al-Khateeb, Iris H Y Kwok, Sammy A Hanna, Mathew D Sewell, Aresh Hashemi-Nejad
Legg-Calve-Perthes disease is characterized by osteonecrosis of the femoral head during childhood. Outcomes of total hip arthroplasty (THA) for these patients are less satisfactory than for those with primary osteoarthritis, often complicated by young patient age, multi-planar deformities and previous childhood surgery. To our knowledge no one has reported the long-term outcomes of cementless custom-made THA in patients with Legg-Calve-Perthes disease. We reviewed 15 THAs with an average follow-up of ten years...
April 2014: Journal of Arthroplasty
Jonathan Wright, Francois Tudor, Thomas Luff, Aresh Hashemi-Nejad
Monitoring of a patient with developmental dysplasia of the hip (DDH) is required after initial treatment to ensure early detection and correction of complications or poor progression. We established the current practice of surveillance in DDH in the UK. A protocol has been designed at this unit with the aim of identifying the stages in the progression of DDH when imaging of the hip is necessary to detect failure or possible complications of treatment. The outcomes and secondary procedure rates under the surveillance protocol used at this unit, for a UK population, have been reviewed with a minimum of 5 years of follow-up...
November 2013: Journal of Pediatric Orthopedics. Part B
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