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https://www.readbyqxmd.com/read/27837547/stable-discoidal-bicelles-a-platform-of-lipid-nanocarriers-for-cellular-delivery
#1
Ying Liu, Yan Xia, Armin Tahmasbi Rad, Wafa Aresh, Mu-Ping Nieh
Bicellar mixtures have been used as alignable membrane substrates for the structural characterization of membrane-associated proteins. Most recently, it has been shown that bicelles can serve as nanocarriers to effectively deliver hydrophobic molecules to cancer cells with a 3- to 10-fold enhancement compared to that of chemically identical liposomes. In this chapter, a detailed preparation protocol, common structural characterization methods, the structural stability and the cellular uptake of bicellar nanodisks are discussed...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27344203/multimodal-eph-ephrin-signaling-controls-several-phases-of-urogenital-development
#2
Christiane Peuckert, Bejan Aresh, Pavlo Holenya, Derek Adams, Smitha Sreedharan, Annika Porthin, Louise Andersson, Hanna Pettersson, Stefan Wölfl, Rüdiger Klein, Leif Oxburgh, Klas Kullander
A substantial portion of the human population is affected by urogenital birth defects resulting from a failure in ureter development. Although recent research suggests roles for several genes in facilitating the ureter/bladder connection, the underlying molecular mechanisms remain poorly understood. Signaling via Eph receptor tyrosine kinases is involved in several developmental processes. Here we report that impaired Eph/Ephrin signaling in genetically modified mice results in severe hydronephrosis caused by defective ureteric bud induction, ureter maturation, and translocation...
August 2016: Kidney International
https://www.readbyqxmd.com/read/27333915/is-this-the-end-of-the-beginning-for-smoking-in-china-challenges-context-and-change
#3
Alexander Aresh Azizi
Tobacco use in China is a substantial threat to global health and, after many years of poor implementation of tobacco control, attitudes are changing for the better and substantial actions may be about to follow. This commentary reviews the impact of tobacco and the recent history of tobacco control in China, the context and implications of new encouraging legislation.
June 22, 2016: Global Health Promotion
https://www.readbyqxmd.com/read/27325204/community-detoxification-for-alcohol-dependence-a-systematic-review
#4
Abhijit Nadkarni, Paige Endsley, Urvita Bhatia, Daniela C Fuhr, Aneesa Noorani, Aresh Naik, Pratima Murthy, Richard Velleman
ISSUES: Despite the potential advantages of community detoxification for alcohol dependence, in many countries the available resources are mostly focused on specialist services that are resource-intensive, and often difficult to access because of financial or geographical factors. The aim of this systematic review is to synthesise the existing literature about the management of alcohol detoxification in the community to examine its effectiveness, safety, acceptability and feasibility...
June 21, 2016: Drug and Alcohol Review
https://www.readbyqxmd.com/read/27140212/epidemiology-of-traffic-crash-mortality-in-west-of-iran-in-a-9-year-period
#5
Behrooz Hamzeh, Farid Najafi, Behzad Karamimatin, Tuoraj Ahmadijouybari, Aresh Salari, Mehdi Moradinazar
PURPOSE: In Iran, the most common cause of injuries and the second leading cause of deaths are traffic accidents, and those problems impose a substantial financial burden on the society. This study aims to determine traffic accident mortality trends and their epidemiologic characteristics in the Kermanshah province, west of Iran. METHODS: In a cross sectional study, road traffic fatality data from 2004 to 2013 were analyzed to determine the epidemiological pattern of traffic accident mortality...
April 1, 2016: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/26994665/the-six-year-outcome-of-alcohol-use-disorders-in-men-a-population-based-study-from-india
#6
Abhijit Nadkarni, Helen A Weiss, Aresh Naik, Bhargav Bhat, Vikram Patel
BACKGROUND: Despite the large and growing public health problem of alcohol use disorders (AUD) in India there is a dearth of evidence about the longitudinal outcomes in AUD. The aim of this study is to describe the course and outcomes of AUD in a population based sample of men in India. METHODS: A community cohort of 1899 adult (18-49 years at baseline) men who participated in a cross-sectional survey in Goa, India between 2006 and 08, were re-interviewed face to face 6 years later (2012-14)...
May 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/26748715/identification-of-a-neuronal-receptor-controlling-anaphylaxis
#7
Katarzyna Rogoz, Bejan Aresh, Fabio Batista Freitag, Hanna Pettersson, Elín Ingibjörg Magnúsdóttir, Linn Larsson Ingwall, Helena Haddadi Andersen, Marina Christina Mikaela Franck, Chetan Nagaraja, Klas Kullander, Malin Charlotta Lagerström
Allergic reactions can in severe cases induce a state of circulatory shock referred to as anaphylaxis. Histamine, the primary mediator of this condition, is released from immune cells, and, therefore, anaphylaxis has so far been considered an immune system disorder. However, we here show that the glutamatergic receptor mGluR7, expressed on a subpopulation of both peripheral and spinal cord neurons, controls histamine-induced communication through calcium-dependent autoinhibition with implications for anaphylaxis...
January 12, 2016: Cell Reports
https://www.readbyqxmd.com/read/26123871/proximal-femoral-excision-with-interposition-myoplasty-for-cerebral-palsy-patients-with-painful-chronic-hip-dislocation
#8
Nirav K Patel, Sanjeeve Sabharwal, Christopher R Gooding, Aresh Hashemi-Nejad, Deborah M Eastwood
PURPOSE: Proximal femoral excision is a salvage procedure for painful chronic hip dislocation in cerebral palsy (CP) patients. The primary objective of this article is to describe our experience of an amplified interposition myoplasty, with appropriate peri-operative pain and tone management strategies, in a cohort of non-ambulatory CP patients with painful chronic hip dislocation. Our secondary objective is to present the clinical outcomes of these patients. METHODS: We describe our experience in 20 CP patients (25 procedures) at mean 54-month (range 27-169) follow-up with a surgical technique that includes an augmented interposition myoplasty and tone management...
August 2015: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/25420470/frailty-and-perioperative-outcomes-a-narrative-review
#9
REVIEW
Thomas Beggs, Aresh Sepehri, Andrea Szwajcer, Navdeep Tangri, Rakesh C Arora
BACKGROUND: Frailty has no single universally accepted definition or method for assessment. It is commonly defined from a physiological perspective as a disruption of homeostatic mechanisms ultimately leading to a vulnerable state. Numerous scoring indices and assessments exist to assist clinicians in determining the frailty status of a patient. The purpose of this review is to discuss the relationship between frailty and perioperative outcomes in surgical patients. PRINCIPAL FINDINGS: We performed a review to determine the association of frailty with perioperative outcomes in patients undergoing a wide variety of surgical procedures...
February 2015: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/25391330/genetic-skeletal-dysplasias-a-guide-to-diagnosis-and-management
#10
REVIEW
Mathew David Sewell, Amanjot Chahal, Nawfal Al-Hadithy, Gordon W Blunn, Sean Molloy, Aresh Hashemi-Nejad
The skeletal dysplasias are a large, heterogeneous group of genetic disorders characterised by abnormal growth, development and remodelling of the bones and cartilage that comprise the human skeleton. They typically present with disproportionate short stature in childhood, or premature osteoarthritis in adulthood. The latest classification lists 456 disorders under 40 group headings differentiated by specific clinical, radiographic and molecular criteria. Establishing an accurate diagnosis is important to predict final height, expected complications and treatment, and for specific genetic and psychological counselling...
2015: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/25199821/the-impact-of-frailty-on-outcomes-after-cardiac-surgery-a-systematic-review
#11
REVIEW
Aresh Sepehri, Thomas Beggs, Ansar Hassan, Claudio Rigatto, Christine Shaw-Daigle, Navdeep Tangri, Rakesh C Arora
OBJECTIVE: Current preoperative assessments for cardiac surgery, such as the European System for Cardiac Operative Risk Evaluation II and the Society of Thoracic Surgeons risk score, are limited in their ability to predict postoperative outcomes. This is thought to be due to the reliance on chronological age as a predictor of health. In geriatrics, frailty assessments have been developed as a tool in determining physiologic functioning capacity. Whether or not frailty predicts postoperative outcomes independent of existing cardiac preoperative risk scores remains unknown...
December 2014: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/24715547/erratum-to-the-bernese-peri-acetabular-osteotomy-through-a-modified-approach-a-technical-note
#12
Paul Whittingham-Jones, Nirav K Patel, Aresh Hashemi-Nejad
No abstract text is available yet for this article.
May 2014: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/24432067/the-bernese-peri-acetabular-osteotomy-through-a-modified-approach-a-technical-note
#13
Paul Whittingham-Jones, Nirav Kirit Patel, Aresh Hashemi-Nejad
INTRODUCTION: A modification of the technique for performing the Bernese periacetabular osteotomy is described. MATERIALS AND METHODS: A medial approach to the Ischium and a subtle re-orientation of the pubic osteotomy are detailed. CONCLUSION: Surgical morbidity is likely decreased with a concurrent cosmetic advantage without compromise to surgical correction or patient safety.
March 2013: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/24396224/resurfacing-hip-arthroplasty-in-neuromuscular-hip-disorders%C3%A2-a-retrospective-case-series
#14
Francois Tudor, Amir Ariamanesh, Anish Potty, Aresh Hashemi-Nejad
BACKGROUND: Management of the degenerate hip in patients with neuromuscular conditions should be aimed at improving quality of life and ease of nursing care. Arthroplasty poses a significant challenge with predisposition to dislocation and loosening due to anatomical abnormalities, soft tissue contractures and impaired muscle tone. METHODS: We present a series of 11 hips (9 patients) following total hip resurfacing arthroplasty for painful osteoarthritis in patients with differing neuromuscular conditions...
2013: Journal of Orthopaedics
https://www.readbyqxmd.com/read/24276116/idiopathic-chondrolysis-of-the-hip-presentation-natural-history-and-treatment-options
#15
REVIEW
Neil Segaren, Hani B Abdul-Jabar, Nicholas Segaren, Aresh Hashemi-Nejad
Idiopathic chondrolysis of the hip is a rare disorder characterized by pain, stiffness, limp and radiological loss of joint space of the affected hip. The clinical outcome varies from complete recovery to fibrous ankylosis. Management remains controversial. We aim to outline the natural history and pathology of the disease and treatment strategies.
March 2014: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/24018160/custom-cementless-tha-in-patients-with-legg-calve-perthes-disease
#16
Hesham Al-Khateeb, Iris H Y Kwok, Sammy A Hanna, Mathew D Sewell, Aresh Hashemi-Nejad
Legg-Calve-Perthes disease is characterized by osteonecrosis of the femoral head during childhood. Outcomes of total hip arthroplasty (THA) for these patients are less satisfactory than for those with primary osteoarthritis, often complicated by young patient age, multi-planar deformities and previous childhood surgery. To our knowledge no one has reported the long-term outcomes of cementless custom-made THA in patients with Legg-Calve-Perthes disease. We reviewed 15 THAs with an average follow-up of ten years...
April 2014: Journal of Arthroplasty
https://www.readbyqxmd.com/read/23812086/surveillance-after-treatment-of-children-with-developmental-dysplasia-of-the-hip-current-uk-practice-and-the-proposed-stanmore-protocol
#17
REVIEW
Jonathan Wright, Francois Tudor, Thomas Luff, Aresh Hashemi-Nejad
Monitoring of a patient with developmental dysplasia of the hip (DDH) is required after initial treatment to ensure early detection and correction of complications or poor progression. We established the current practice of surveillance in DDH in the UK. A protocol has been designed at this unit with the aim of identifying the stages in the progression of DDH when imaging of the hip is necessary to detect failure or possible complications of treatment. The outcomes and secondary procedure rates under the surveillance protocol used at this unit, for a UK population, have been reviewed with a minimum of 5 years of follow-up...
November 2013: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/23558048/water-based-gas-purge-microsyringe-extraction-coupled-with-liquid-chromatography-for-determination-of-alkylphenols-from-sea-food-laminaria-japonica-aresh
#18
Cui Yang, Jinhua Zhao, Juan Wang, Hongling Yu, Xiangfan Piao, Donghao Li
A novel organic solvent-free mode of gas purge microsyringe extraction, termed water-based gas purge microsyringe extraction, was developed. This technique can directly extract target compounds in wet samples without any drying process. Parameters affecting the extraction efficiency were investigated. Under optimal extraction conditions, the recoveries of alkylphenols were between 87.6 and 105.8%, and reproducibility was between 5.2 and 12.1%. The technique was also used to determine six kinds of alkylphenols (APs) from samples of Laminaria japonica Aresh...
July 26, 2013: Journal of Chromatography. A
https://www.readbyqxmd.com/read/23233183/total-hip-arthroplasty-in-teenagers-an-alternative-to-hip-arthrodesis
#19
Nirav K Patel, Thomas Luff, Paul Whittingham-Jones, Christopher R Gooding, Aresh Hashemi-Nejad
Debilitating arthritis in teenage patients is a complex problem with limited surgical options. Hip arthrodesis is unpopular amongst patients, and contemporary total hip arthroplasty (THA) may be a promising alternative. We report on the outcomes of THA in patients less than 20 years of age. All consecutive teenage patients undergoing THA at a tertiary referral centre were reviewed. Mean follow-up was 3.4 years (range 0.6-6.8) and 9 patients had at least 5 years follow-up. There were 51 THAs in 43 patients with a mean age of 17 years (range 12-19)...
November 2012: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/21686671/strong-diabetes
#20
James Young, Aresh Anwar
The case of a 36-year-old male professional bodybuilder is reported. He presented to the accident and emergency department with right upper quadrant pain. This was on the background of a 15-year history of anabolic steroid and growth hormone misuse. Examination revealed mild hepatomegaly and a random blood sugar of 30.2 mmol/l. There was no evidence of ketonuria or acidosis. Biochemical evidence of hepatitis was found, and the patient was in acute renal failure. He was given a sliding scale of insulin and an intravenous infusion of crystalloid...
2009: BMJ Case Reports
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