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https://www.readbyqxmd.com/read/27915322/ocular-morbidity-associated-with-retinopathy-of-prematurity-in-treated-and-untreated-eyes-a-review-of-the-literature-and-data-from-a-tertiary-eye-care-center-in-southern-india
#1
Perumalsamy Vijayalakshmi, Tulika Kara, Clare Gilbert
Retinopathy of prematurity (ROP) is an emerging cause of childhood blindness in low- and middle-income countries. We review the magnitude, causes, prevention and treatment of visual impairment caused by ROP over a time span. A review of literature on short and long term structural and functional outcomes of ROP was conducted through PubMed search primarily focusing on studies published during the last decade. Additionally, we have shared data from our institute located in Southern India. Visual Impairment in ROP-treated children ranged from 4...
November 7, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27914822/effects-of-sodium-thiosulfate-versus-observation-on-development-of-cisplatin-induced-hearing-loss-in-children-with-cancer-accl0431-a-multicentre-randomised-controlled-open-label-phase-3-trial
#2
David R Freyer, Lu Chen, Mark D Krailo, Kristin Knight, Doojduen Villaluna, Bonnie Bliss, Brad H Pollock, Jagadeesh Ramdas, Beverly Lange, David Van Hoff, Michele L VanSoelen, John Wiernikowski, Edward A Neuwelt, Lillian Sung
BACKGROUND: Sodium thiosulfate is an antioxidant shown in preclinical studies in animals to prevent cisplatin-induced hearing loss with timed administration after cisplatin without compromising the antitumour efficacy of cisplatin. The primary aim of this study was to assess sodium thiosulfate for prevention of cisplatin-induced hearing loss in children and adolescents. METHODS: ACCL0431 was a multicentre, randomised, open-label, phase 3 trial that enrolled participants at 38 participating Children's Oncology Group hospitals in the USA and Canada...
November 30, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27914475/an-observational-study-of-febrile-seizures-the-importance-of-viral-infection-and-immunization
#3
Joshua R Francis, Peter Richmond, Christine Robins, Katie Lindsay, Avram Levy, Paul V Effler, Meredith Borland, Christopher C Blyth
BACKGROUND: Febrile seizures are common in young children. Annual peaks in incidence mirror increased respiratory virus activity during winter. Limited virological data are available using modern diagnostic techniques for children with febrile seizures. We aimed to determine the frequency of detection of specific viral pathogens in children with febrile seizures, to describe risk factors including recent vaccination and clinical features associated with specific etiologies. METHODS: An observational study was performed...
December 3, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27914364/structure-based-exploration-and-exploitation-of-the-s4-subsite-of-norovirus-3cl-protease-in-the-design-of-potent-and-permeable-inhibitors
#4
Anushka C Galasiti Kankanamalage, Yunjeong Kim, Athri D Rathnayake, Vishnu C Damalanka, Pathum M Weerawarna, Sean T Doyle, Amer F Alsoudi, D M Padmasankha Dissanayake, Gerald H Lushington, Nurjahan Mehzabeen, Kevin P Battaile, Scott Lovell, Kyeong-Ok Chang, William C Groutas
Human noroviruses are the primary cause of epidemic and sporadic acute gastroenteritis. The worldwide high morbidity and mortality associated with norovirus infections, particularly among the elderly, immunocompromised patients and children, constitute a serious public health concern. There are currently no approved human vaccines or norovirus-specific small-molecule therapeutics or prophylactics. Norovirus 3CL protease has recently emerged as a potential therapeutic target for the development of anti-norovirus agents...
November 14, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27914312/today-is-tomorrow-s-yesterday-children-s-acquisition-of-deictic-time-words
#5
Katharine A Tillman, Tyler Marghetis, David Barner, Mahesh Srinivasan
Deictic time words like "yesterday" and "tomorrow" pose a challenge to children not only because they are abstract, and label periods in time, but also because their denotations vary according to the time at which they are uttered: Monday's "tomorrow" is different than Thursday's. Although children produce these words as early as age 2 or 3, they do not use them in adult-like ways for several subsequent years. Here, we explored whether children have partial but systematic meanings for these words during the long delay before adult-like usage...
November 30, 2016: Cognitive Psychology
https://www.readbyqxmd.com/read/27914237/religion-in-child-sexual-abuse-forensic-interviews
#6
Amy C Tishelman, Lisa A Fontes
Religion is an under-studied factor affecting children's sexual victimization and their willingness to discuss such experiences. In this qualitative study, 39 child forensic interviewers and child advocacy center (CAC) directors in the United States discussed religious influences on children's sexual abuse experiences, their relationships to CACs, and their disclosures in the forensic setting. Participants reported both harmonious and dissonant interactions between religiously observant children and families on one hand and child advocacy centers on the other...
November 30, 2016: Child Abuse & Neglect
https://www.readbyqxmd.com/read/27913502/mrd-in-aml-does-it-already-guide-therapy-decision-making
#7
Gert Ossenkoppele, Gerrit Jan Schuurhuis
Prognostic factors determined at diagnosis are predictive for outcome whereas achievement of morphological complete remission (CR) is still an important end point during treatment. Residual disease after therapy may reflect the sum of all diagnosis and postdiagnosis resistance mechanisms/factors; its measurement could hypothetically be very instrumental for guiding treatment. The possibility of defining residual disease (minimal residual disease [MRD]) far below the level of 5% blast cells is changing the landscape of risk classification...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27913211/sgrasp-a-graph-based-method-for-the-derivation-of-subject-specific-functional-parcellations-of-the-brain
#8
N Honnorat, T D Satterthwaite, R E Gur, R C Gur, C Davatzikos
BACKGROUND: Resting-state fMRI (rs-fMRI) has emerged as a prominent tool for the study of functional connectivity. The identification of the regions associated with the different brain functions has received significant interest. However, most of the studies conducted so far have focused on the definition of a common set of regions, valid for an entire population. The variation of the functional regions within a population has rarely been accounted for. New Method: In this paper, we propose sGraSP, a graph-based approach for the derivation of subject-specific functional parcellations...
November 29, 2016: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/27912950/a-randomized-placebo-controlled-trial-of-traditional-chinese-medicine-as-an-add-on-therapy-to-oral-montelukast-in-the-treatment-of-mild-persistent-asthma-in-children
#9
Pak-Hong Chan, Ching-Yee To, Eric Yat-Tung Chan, Handong Li, Xiuxia Zhang, Pok-Yu Chow, Po-Ling Liu, Shuk-Yu Leung, Chung-Hong Chan, Ka-Yan Chan, Johnny Yick-Chun Chan, Jonathan Pak-Heng Ng, Daniel Kwok-Keung Ng
OBJECTIVES: Traditional Chinese medicine are commonly used for treatment of asthma. However, there are only very limited data about its efficacy in children. Therefore, we aimed to determine the efficacy of augmented Yu Ping Feng San (aYPFS) as an add-on to oral montelukast compared with montelukast alone for treatment of mild persistent asthma in children. DESIGN: A single centre, placebo-controlled, double-blinded, randomized control trial was carried out. Participants with age 6-18 years who had mild persistent asthma were randomized according to random number list to receive either aYPFS plus montelukast for 24 weeks or placebo plus montelukast for 24 weeks...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27911891/severe-carbamazepine-intoxication-in-children-analysis-of-a-40-case-series
#10
Mehmet Acikgoz, M Sukru Paksu, Ahmet Guzel, Abdurrahman Alacam, Fatma Alacam
BACKGROUND We compared the factors that might impact the severity and the prognosis of carbamazepine (CBZ) intoxication in children, as well as the efficacy levels of the treatment options. MATERIAL AND METHODS Demographic information and clinical and laboratory findings for 40 patients were evaluated retrospectively. Predictive parameters for the development of serious complications were studied. RESULTS Median age of patients was 14 years; 65% of the patients were female. The most common pathological clinical finding and laboratory abnormality were inability to awaken the patient and hyperglycemia (45% and 60%, respectively)...
December 2, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27911143/factors-predicting-life-threatening-infections-with-respiratory-syncytial-virus-in-adult-patients
#11
Se Yoon Park, Taeeun Kim, Young Rock Jang, Min-Chul Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim
BACKGROUND: Respiratory syncytial virus (RSV) is a significant cause of acute respiratory illness with a clinical spectrum ranging from self-limiting upper respiratory infection to severe lower respiratory infection in elderly persons as well as young children. However, there are limited data on risk factors for life-threatening infections that could guide the appropriate use of antiviral agents in adult patients with RSV. METHODS: We conducted a retrospective cohort study from October 2013 to September 2015...
December 2, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27910723/powered-mobility-intervention-understanding-the-position-of-tool-use-learning-as-part-of-implementing-the-alp-tool
#12
Lisbeth Nilsson, Josephine Durkin
PURPOSE: To explore the knowledge necessary for adoption and implementation of the Assessment of Learning Powered mobility use (ALP) tool in different practice settings for both adults and children. To consult with a diverse population of professionals working with adults and children, in different countries and various settings; who were learning about or using the ALP tool, as part of exploring and implementing research findings. METHOD: Classical grounded theory with a rigorous comparative analysis of data from informants together with reflections on our own rich experiences of powered mobility practice and comparisons with the literature...
December 2, 2016: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/27909850/a-rural-urban-comparison-in-emergency-department-visits-for-u-s-children-with-autism-spectrum-disorder
#13
Wanqing Zhang, Ashley E Mason, Brian Boyd, Linmarie Sikich, Grace Baranek
We examined rural-urban differences in emergency department visits, and child and clinical characteristics associated with visits for U.S. children aged 3-17 years with autism spectrum disorder (ASD). Rural children with ASD were twice more likely to have emergency department visits in urban hospitals than rural children without ASD. The children with ASD in rural areas were economically disadvantaged and concentrated in the South and Midwest regions. Rural children diagnosed with ASD and multiple comorbidities during emergency department visits were 1...
December 1, 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27908797/molecular-detection-and-characterization-of-respiratory-syncytial-virus-b-genotypes-circulating-in-pakistani-children
#14
Uzma Bashir, Nadia Nisar, Nayab Mahmood, Muhammad Masroor Alam, Hajra Sadia, Syed Sohail Zahoor Zaidi
Respiratory syncytial virus (RSV) is the major cause of acute lower respiratory tract infections in young children, but very little is known about its epidemiology and circulating genotypes in Pakistan. This study analyzed the epidemiological and molecular characteristics of RSV B genotypes in Pakistani children below 5years with acute respiratory tract infections (ARIs) during three consecutive winter seasons from 2010 to 2013. A total of 1941 samples were analyzed for RSV infection by real time PCR and 24% (472/1941) samples were found positive out of which 22...
November 28, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27908536/the-sensitivity-and-negative-predictive-value-of-a-pediatric-cervical-spine-clearance-algorithm-that-minimizes-computerized-tomography
#15
Mary Arbuthnot, David P Mooney
BACKGROUND: It is crucial to identify cervical spine injuries while minimizing ionizing radiation. This study analyzes the sensitivity and negative predictive value of a pediatric cervical spine clearance algorithm. METHODS: We performed a retrospective review of all children <21years old who were admitted following blunt trauma and underwent cervical spine clearance utilizing our institution's cervical spine clearance algorithm over a 10-year period. Age, gender, International Classification of Diseases 9th Edition diagnosis codes, presence or absence of cervical collar on arrival, Injury Severity Score, and type of cervical spine imaging obtained were extracted from the trauma registry and electronic medical record...
October 27, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27906843/comparison-of-resorbable-plating-systems-complications-during-degradation
#16
Dennis C Nguyen, Albert S Woo, Scott J Farber, Gary B Skolnick, Jenny Yu, Sybill D Naidoo, Kamlesh B Patel
INTRODUCTION: Several bioresorbable plating systems have become standard in pediatric craniosynostosis reconstruction. A comparison of these systems is needed to aid surgeons in the preoperative planning process. The authors aim to evaluate 1 institution's experience using Resorb-X by KLS Martin and Delta Resorbable Fixation System by Stryker (Stryker Craniomaxillofacial, Kalamazoo, MI). METHODS: A sample of patients with single-suture nonsyndromic craniosynostosis treated at St Louis Children's Hospital between 2007 and 2014 using either Resorb-X or Delta bioresorbable plating systems were reviewed...
November 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27906643/sports-and-recreation-related-injury-episodes-in-the-united-states-2011-2014
#17
Yahtyng Sheu, Li-Hui Chen, Holly Hedegaard
Objective-Much of the research on sports- and recreation-related injuries focuses on a specific population, activity, or type of injury, and national estimates of the total burden of sports- and recreation-related injuries are limited. This study provides national estimates of the injury burden and examines the distribution of sports- and recreation-related injuries across demographic groups, activities, and injury circumstances. Methods-Information on medically attended injury episodes for persons aged 5 years and over were obtained from the 2011-2014 National Health Interview Survey...
November 2016: National Health Statistics Reports
https://www.readbyqxmd.com/read/27905982/the-use-of-a-lot-quality-assurance-sampling-methodology-to-assess-and-manage-primary-health-interventions-in-conflict-affected-west-darfur-sudan
#18
Kiemanh Pham, Emily Chambers Sharpe, William M Weiss, Alexander Vu
BACKGROUND: Organizations working in conflict-affected areas have a need to monitor and evaluate their programs, however this is often difficult due to the logistical challenges of conflict areas. Lot quality assurance sampling may be a suitable method of assessing programs in these situations. METHODS: We conducted a secondary data analysis of information collected during Medair's routine program management functions. Medair's service area in West Darfur, Sudan was divided into seven supervisory areas...
October 6, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27905907/addressing-asthma-and-obesity-in-children-with-community-health-workers-proof-of-concept-intervention-development
#19
Molly A Martin, Steven K Rothschild, Elizabeth Lynch, Katherine Kaufer Christoffel, Militza M Pagán, Jose Luis Rodriguez, Anna Barnes, Kelly Karavolos, Antonieta Diaz, Lucretia M Hoffman, Diana Plata, Sandra Villalpando
BACKGROUND: The objective of this study was to design and test the feasibility and impact of a community health worker (CHW) intervention for comorbid asthma and obesity. METHODS: Using a proof of concept study design, we collected pre/post outcomes from a single intervention cohort of urban low-income in a single community area. A community-based participatory research approach was employed. Forty-six children and their caregivers were recruited. Children were 5-12 years old with physician-diagnosed asthma and body mass index (BMI) > 85%...
December 1, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27905867/effects-of-lawn-tennis-association-mini-tennis-as-task-constraints-on-children-s-match-play-characteristics
#20
Anna Fitzpatrick, Keith Davids, Joseph Antony Stone
The Lawn Tennis Association's mini tennis (MT) is a modified version of tennis consisting of progressive stages; however, there have been few attempts to evaluate how MT might shape performance behaviours. Here, we examine effects of playing MT on the emergence of children's match-play behaviours in 48 junior tennis players. Performance in 1010 match-play points were filmed and coded across 4 tennis stages (MT Red, MT Orange, MT Green and Full Ball), using a notational analysis system. Recorded performance variables included rally length, first serve percentage and shot type, for the purpose of analysing inter-stage comparisons...
December 1, 2016: Journal of Sports Sciences
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