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macrocytic anemia and cll

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https://www.readbyqxmd.com/read/24010694/-review-of-evidence-of-thalidomide-and-lenalidomide-in-different-hematological-diseases-chronic-lymphocytic-leukemia-primary-amyloidosis-myelofibrosis-and-syndrome-myelodysplastic
#1
REVIEW
I Jiménez Lozano, J C Juárez Jiménez
Lenalidomide is an immunomodulatory drug approved by the AEMPS and the EMA, in combination with dexamethasone, for the treatment of multiple myeloma in adult patients who have received at least one prior therapy. Moreover, it has recently been approved for the treatment of patients with transfusion-dependent anaemia due to low- or intermediate-1-risk myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormality when other therapeutic options are insufficient or inadequate. It has also shown to be active in other hematologic and no hematologic diseases...
July 2013: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/7521818/two-color-flow-cytometric-analysis-of-concomitant-acute-myeloid-leukemia-and-chronic-lymphocytic-leukemia
#2
K R Tamul, D C Meyers, S A Bentley, J D Folds
During evaluation for macrocytic anemia and thrombocytopenia, a 74-year-old female was found to have a leukocytosis with two apparent populations of malignant cells identified in her peripheral blood smear and bone marrow aspirate. Morphologic characteristics of the two cell types were unusual, and cytochemical assays yielded ambiguous results. Two-color flow cytometric analysis demonstrated two distinct cell populations with immunophenotyping patterns consistent with chronic lymphocytic leukemia (CD5+/CD20+) and acute myelocytic leukemia (CD33+/CD34+), detected concurrently...
March 15, 1994: Cytometry
https://www.readbyqxmd.com/read/6600413/cell-mediated-inhibition-of-erythropoiesis-and-megaloblastic-anemia-in-t-cell-chronic-lymphocytic-leukemia
#3
W G Hocking, R Singh, R Schroff, D W Golde
A patient with T-cell chronic lymphocytic leukemia presented with severe megaloblastic anemia with normal serum folic acid and cobalamin concentrations. BFU-E could not be cultured from the patient's peripheral blood unless T-lymphocytes were removed by E-rosette formation. Inhibitory activity by the patient's T-cells was restricted to autologous BFU-E. After cyclic chemotherapy the anemia and megaloblastic changes resolved, peripheral blood BFU-E could be cultured from unfractionated peripheral blood and the T-cell inhibitory activity could no longer be demonstrated...
February 15, 1983: Cancer
https://www.readbyqxmd.com/read/3082188/t-cell-chronic-lymphocytic-leukemia-with-pure-red-cell-aplasia-laboratory-demonstration-of-persistent-leukemia-in-spite-of-apparent-complete-clinical-remission
#4
R M Hansen, N Lerner, R A Abrams, C W Patrick, M I Malik, R Keller
A 40-year-old woman presented with splenomegaly, macrocytic anemia, and red cell aplasia. Although lymphocytosis was absent in the peripheral blood, large atypical lymphoid aggregates were present in the bone marrow. Splenectomy resulted in partial remission of red cell aplasia, but a gradual increase in the number of peripheral blood lymphocytes followed during the next 36 months. Flow cytometric analysis demonstrated that the majority of these peripheral blood lymphocytes had suppressor, natural killer T-cell phenotype...
May 1986: American Journal of Hematology
https://www.readbyqxmd.com/read/2133609/-chronic-lymphocytic-leukemia-complicated-by-pernicious-anemia-during-long-term-remission
#5
R Ruvidić, D Bosković
Chronic lymphocytic leukaemia was diagnosed in 1957 in a 29-year-old male patient who lived 31 years after that time. At the time of diagnosis he was in good general condition with the enlarged liver (4 cm) and spleen (5 cm). In peripheral blood the leukocyte count was 47 x 10(9)/1 with 80% lymphocytes (38 x 10(9)/1), Hb 106 g/1; the bone marrow showed hypercellularity with predominance of lymphocytes. Treatment with corticosteroids was during 1958-1966. In 1967 Chlorambucil was given for 3 months, in 1972 for one month, inducing normalization of leukocyte count, 5...
November 1990: Srpski Arhiv za Celokupno Lekarstvo
https://www.readbyqxmd.com/read/413778/hematologic-problems-of-the-elderly
#6
R Baisden
Since hemoglobin and hematocrit values tend to be low in the elderly, confirming the presence of anemia and establishing its etiology involve complex considerations. Also discussed are such proliferative disorders as chronic lymphocytic leukemia.
January 1978: Hospital Practice
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