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Supplement AND adiponectin

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https://www.readbyqxmd.com/read/28942443/a-novel-role-of-sirt1-fgf-21-in-taurine-protection-against-cafeteria-diet-induced-steatohepatitis-in-rats
#1
Azza H Abd Elwahab, Basma K Ramadan, Mona F Schaalan, Amina M Tolba
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is one of the alarmingly rising clinical problems in the 21st century with no effective drug treatment until now. Taurine is an essential amino acid in humans that proved efficacy as a non-pharmacological therapy in a plethora of diseases; however, its impact on NAFLD remains elusive. The aim of the current study is to evaluate the protective mechanism of taurine in experimental steatohepatitis induced by junk food given as cafeteria-diet (CAF-D) in male albino rats...
September 22, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28934139/phyllodulcin-a-natural-sweetener-regulates-obesity-related-metabolic-changes-and-fat-browning-related-genes-of-subcutaneous-white-adipose-tissue-in-high-fat-diet-induced-obese-mice
#2
Eunju Kim, Soo-Min Lim, Min-Soo Kim, Sang-Ho Yoo, Yuri Kim
Phyllodulcin is a natural sweetener found in Hydrangea macrophylla var. thunbergii. This study investigated whether phyllodulcin could improve metabolic abnormalities in high-fat diet (HFD)-induced obese mice. Animals were fed a 60% HFD for 6 weeks to induce obesity, followed by 7 weeks of supplementation with phyllodulcin (20 or 40 mg/kg body weight (b.w.)/day). Stevioside (40 mg/kg b.w./day) was used as a positive control. Phyllodulcin supplementation reduced subcutaneous fat mass, levels of plasma lipids, triglycerides, total cholesterol, and low-density lipoprotein cholesterol and improved the levels of leptin, adiponectin, and fasting blood glucose...
September 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28917230/energy-restriction-combined-with-green-coffee-bean-extract-affects-serum-adipocytokines-and-the-body-composition-in-obese-women
#3
Fatemeh Haidari, Mehnoosh Samadi, Majid Mohammadshahi, Mohammad Taha Jalali, Kambiz Ahmadi Engali
BACKGROUND AND OBJECTIVES: Obesity has become a public health problem and is a cause of some preventable illnesses. Among several methods for treating obesity, the use of food supplements is highly common. A commonly used food supplement is green coffee bean extract. The objective of this study was to evaluate the efficacy of green coffee bean extract combined with an energy-restricted diet on the body composition and serum adipocytokines in obese women. METHODS AND STUDY DESIGN: In this randomised clinical trial, 64 obese women aged 20-45 years were selected and divided into two groups: an intervention group (receiving 400 mg green coffee bean extract for 8 weeks) and control group (receiving placebo)...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28894517/effects-of-probiotic-and-prebiotic-supplementation-on-leptin-adiponectin-and-glycemic-parameters-in-non-alcoholic-fatty-liver-disease-a-randomized-clinical-trial
#4
Vahideh Behrouz, Shima Jazayeri, Naheed Aryaeian, Mohamad Javad Zahedi, Fatemeh Hosseini
BACKGROUND According to previous studies, probiotic and prebiotic supplementation have desirable effects on glycemic parameters. Thus far, the effect of supplementation on the glycemic parameters and adipokines in non-alcoholic fatty liver disease (NAFLD) has not been assessed. Therefore, the aim of this study was to determine the effects of supplementation with probiotic and prebiotic on adiokines and glycemic parameters in the patients with NAFLD. METHODS In the present randomized, double-blind, placebo-controlled trial, 89 patients with NAFLD were randomly divided into three groups to receive one probiotic capsule + 16 g/d maltodextrin (probiotic group) or 16 g/d oligofructose powder + one placebo capsule (prebiotic group), and one placebo capsule + 16 g/d maltodextrin (control group) for 12 weeks...
July 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28886012/the-adiponectin-receptor-adipor2-and-its-caenorhabditis-elegans-homolog-paqr-2-prevent-membrane-rigidification-by-exogenous-saturated-fatty-acids
#5
Ranjan Devkota, Emma Svensk, Mario Ruiz, Marcus Ståhlman, Jan Borén, Marc Pilon
Dietary fatty acids can be incorporated directly into phospholipids. This poses a specific challenge to cellular membranes since their composition, hence properties, could greatly vary with different diets. That vast variations in diets are tolerated therefore implies the existence of regulatory mechanisms that monitor and regulate membrane compositions. Here we show that the adiponectin receptor AdipoR2, and its C. elegans homolog PAQR-2, are essential to counter the membrane rigidifying effects of exogenously provided saturated fatty acids...
September 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28873415/proliferative-endocrine-effects-of-adipose-tissue-from-obese-animals-on-mcf7-cells-are-ameliorated-by-resveratrol-supplementation
#6
Christopher F Theriau, O'Llenecia S Sauvé, Marie-Soleil Beaudoin, David C Wright, Michael K Connor
Obesity is clearly associated with an increased risk of breast cancer in postmenopausal women. The purpose was to determine if obesity alters the adipocyte adipokine secretion profile, thereby altering the adipose-dependent paracrine/endocrine growth microenvironment surrounding breast cancer cells (MCF7). Additionally, we determined whether resveratrol (RSV) supplementation can counteract any obesity-dependent effects on breast cancer tumor growth microenvironment. Obese ZDF rats received standard chow diet or diet supplemented with 200 mg/kg body weight RSV...
2017: PloS One
https://www.readbyqxmd.com/read/28870184/agrimonia-pilosa-ledeb-aqueous-extract-improves-impaired-glucose-tolerance-in-high-fat-diet-fed-rats-by-decreasing-the-inflammatory-response
#7
Hwan Hee Jang, Song Yee Nam, Mi Ju Kim, Jung Bong Kim, Jeong Sook Choi, Haeng Ran Kim, Young Min Lee
BACKGROUND: Agrimonia pilosa Ledeb. is a medicinal plant with physiological activities such as anti-cancer, antioxidant, anti-inflammatory activities and in vitro anti-diabetic activity. However, the effects of aqueous extracts from A. pilosa on insulin-resistant rats have not yet been examined. We investigated the effects of aqueous extract from A. pilosa on impaired glucose metabolism induced by a high-fat diet in rats. METHODS: Male Sprague-Dawley rats were assigned to the following groups: normal-fat diet (NF, n = 9); high-fat diet (HF, n = 9); high-fat diet with 0...
September 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28821417/single-species-versus-dual-species-probiotic-supplementation-as-an-emerging-therapeutic-strategy-for-obesity
#8
G Karimi, R Jamaluddin, N Mohtarrudin, Z Ahmad, H Khazaai, M Parvaneh
BACKGROUND AND AIM: Recent studies have reported beneficial effects of specific probiotics on obesity. However, the difference in the anti-obesity effects of probiotics as single species and dual species is still uncertain. Therefore, we aimed to compare the efficacy of single and dual species of bacteria on markers of obesity in high-fat diet-induced obese rats. METHODS AND RESULTS: A total of 40 male Sprague-Dawley rats were assigned to one of five groups of varying diets as follows: standard diet, high fat diet (HFD), HFD supplemented with Lactobacillus casei strain Shirota, HFD supplemented with Bifidobacterium longum and HFD supplemented with a mixture of these two bacterial species...
July 8, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28814950/morinda-citrifolia-l-leaf-extract-prevent-weight-gain-in-sprague-dawley-rats-fed-a-high-fat-diet
#9
Najla Gooda Sahib Jambocus, Amin Ismail, Alfi Khatib, Fawzi Mahomoodally, Nazamid Saari, Muhammad Waseem Mumtaz, Azizah Abdul Hamid
Background: Morinda citrifolia L. is widely used as a folk medicinal food plant to manage a panoply of diseases, though no concrete reports on its potential anti-obesity activity. This study aimed to evaluate the potential of M. citrifolia leaf extracts (MLE60) in the prevention of weight gain in vivo and establish its phytochemical profile. Design: Male Sprague-Dawley rats were divided into groups based on a normal diet (ND) or high fat diet (HFD), with or without MLE60 supplementation (150 and 350 mg/kg body weight) and assessed for any reduction in weight gain...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28755973/l-cysteine-supplementation-increases-insulin-sensitivity-mediated-by-upregulation-of-gsh-and-adiponectin-in-high-glucose-treated-3t3-l1-adipocytes
#10
Arunkumar E Achari, Sushil K Jain
Diabetic patients have lower blood levels of l-cysteine (LC) and glutathione (GSH). This study examined the hypothesis that LC supplementation positively up regulates the effects of insulin on GSH and glucose metabolism in 3T3-L1 adipocyte model. 3T3L1 adipocytes were treated with LC (250 μM, 2 h) and/or insulin (15 or 30 nM, 2 h), and high glucose (HG, 25 mM, 20 h). Results showed that HG caused significant increase (95%) in ROS and reduction in the protein levels of DsbA-L (43%), adiponectin (64%), GCLC (20%), GCLM (21%), GSH (50%), and GLUT-4 (23%) in adipocytes...
September 15, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28752873/dietary-linoleic-acid-intake-and-blood-inflammatory-markers-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
Hang Su, Ruijie Liu, Ming Chang, Jianhua Huang, Xingguo Wang
PURPOSE: The aim of the present study was to investigate the effect of increasing dietary linoleic acid (LA) intake on the blood concentrations of inflammatory markers including cytokines, acute phase reactants and adhesion molecules in adults. METHODS: We comprehensively searched PubMed, Embase and Cochrane Library for eligible studies. Overall, 30 randomized controlled studies involving 1377 subjects were included for meta-analysis. RESULTS: No significant effect of higher LA intake was observed for cytokines: tumor necrosis factor (SMD: -0...
September 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28743192/searching-for-evidence-of-an-anti-inflammatory-diet-in-children-a-systematic-review-of-randomized-controlled-trials-for-pediatric-obesity-interventions-with-a-focus-on-leptin-ghrelin-and-adiponectin
#12
Kimberly A Lewis, Sharon A Brown
PROBLEM: To address the complex phenomenon of pediatric obesity, one must understand the physiological mechanisms regulating energy intake and inflammation. The peptide hormones leptin, ghrelin, and adiponectin are involved in both, but their functions are dysregulated in obesity. The purpose of this systematic review is (1) to characterize studies of nutrition interventions for weight management in children who measure these peptides as outcomes, (2) to assess risk of bias in the studies, and (3) to determine the relationships between these peptides and body mass index (BMI)...
January 1, 2017: Biological Research for Nursing
https://www.readbyqxmd.com/read/28725629/evaluation-the-effect-of-50-and-100%C3%A2-mg-doses-of-cuminum-cyminum-essential-oil-on-glycemic-indices-insulin-resistance-and-serum-inflammatory-factors-on-patients-with-diabetes-type-ii-a-double-blind-randomized-placebo-controlled-clinical-trial
#13
Sahar Jafari, Roghieh Sattari, Sa'id Ghavamzadeh
AIM: The purpose of this study was to evaluate the effect of 50 and 100 mg doses of green cumin essential oil on glycemic and inflammatory indices in patients with diabetes type II. METHOD: In this randomized double-blind placebo-controlled clinical trial, subjects were divided into three groups after selecting them randomly according to the inclusion criteria: 1 - Cuminum cyminum capsule (100 mg/day,n = 33), 2 - C. cyminum capsule (50 mg/day, n = 33), and 3 - placebo (n = 33)...
July 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28721137/beneficial-effects-of-n-3-polyunsaturated-fatty-acids-on-adiponectin-levels-and-adipor-gene-expression-in-patients-with-type-2-diabetes-mellitus-a-randomized-placebo-controlled-double-blind-clinical-trial
#14
Maryam Mazaherioun, Ahmad Saedisomeolia, Mohammad Hassan Javanbakht, Fariba Koohdani, Mohammad Reza Eshraghian, Mahmoud Djalali
INTRODUCTION: There is evidence that n-3 polyunsaturated fatty acids (n-3 PUFAs) exert beneficial effects to improve type 2 diabetes mellitus (T2DM), but its complications remain poorly understood. Hypoadiponectinemia is one of the important mechanisms responsible for T2DM which necessitates developing novel therapeutic strategies. We aimed to determine the effect of n-3 PUFA supplementation on circulating adiponectin and mRNA expression of adiponectin receptors (AdipoR1, AdipoR2) and Sirt-1 in T2DM patients...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28686216/butyrate-reduces-hfd-induced-adipocyte-hypertrophy-and-metabolic-risk-factors-in-obese-ldlr-leiden-mice
#15
Charlotte E Pelgrim, Bart A A Franx, Jessica Snabel, Robert Kleemann, Ilse A C Arnoldussen, Amanda J Kiliaan
Adipose tissue (AT) has a modulating role in obesity-induced metabolic complications like type 2 diabetes mellitus (T2DM) via the production of so-called adipokines such as leptin, adiponectin, and resistin. The adipokines are believed to influence other tissues and to affect insulin resistance, liver function, and to increase the risk of T2DM. In this study, we examined the impact of intervention with the short-chain fatty acid butyrate following a high-fat diet (HFD) on AT function and other metabolic risk factors associated with obesity and T2DM in mice during mid- and late life...
July 7, 2017: Nutrients
https://www.readbyqxmd.com/read/28668709/isomalto-oligosaccharides-a-prebiotic-functionally-augment-green-tea-effects-against-high-fat-diet-induced-metabolic-alterations-via-preventing-gut-dysbacteriosis-in-mice
#16
Dhirendra Pratap Singh, Jagdeep Singh, Ravneet Kaur Boparai, JianHua Zhu, Shrikant Mantri, Pragyanshu Khare, Romesh Khardori, Kanthi Kiran Kondepudi, Kanwaljit Chopra, Mahendra Bishnoi
High fat diet (HFD)-induced alterations in gut microbiota and resultant 'leaky gut' phenomenon promotes metabolic endotoxemia, ectopic fat deposition, and low-grade systemic inflammation. Here we evaluated the effects of a combination of green tea extract (GTE) with isomalto-oligosaccharide (IMOs) on HFD-induced alterations in mice. Male Swiss albino mice were fed with HFD (58% fat kcal) for 12 weeks. Systemic adiposity, gut derangement parameters and V3-V4 region based 16S rRNA metagenomic sequencing, ectopic fat deposition, liver metabolome analysis, systemic and tissue inflammation, and energy homeostasis markers along with gene expression analysis in multiple tissues were done in mice supplemented with GTE, IMOs or their combination...
June 28, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28651330/rosiglitazone-improves-insulin-resistance-mediated-by-10-12-conjugated-linoleic-acid-in-a-male-mouse-model-of-metabolic-syndrome
#17
Shari Wang, Leela Goodspeed, Katherine E Turk, Barbara Houston, Laura J den Hartigh
Trans-10, cis-12 conjugated linoleic acid (10,12 CLA) is a dietary fatty acid that promotes weight loss and disproportionate fat loss. Obese mice fed a high-fat, high-sucrose (HFHS) diet containing 10,12 CLA are resistant to weight gain and contain markedly reduced subcutaneous fat and adiponectin, with a concurrent lack of improvement in insulin sensitivity despite significant weight loss. Taken together, 10,12 CLA promotes a phenotype resembling peroxisome proliferator-activated receptor (PPAR)γ antagonism...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28649655/gene-expression-in-breast-and-adipose-tissue-after-12-months-of-weight-loss-and-vitamin-d-supplementation-in-postmenopausal-women
#18
Caitlin Mason, Lei Wang, Catherine Duggan, Ikuyo Imayama, Sushma S Thomas, Ching-Yun Wang, Larissa A Korde, Anne McTiernan
Adipose tissue is involved in the etiology of postmenopausal breast cancer, possibly through increased sex steroid hormone production, inflammation, and altered adipokines. Vitamin D may affect these pathways but its effect on gene expression in different tissues has not been examined. Within a double-blind, 12-month placebo-controlled randomized trial, we compared 2000 IU/day oral vitamin D3 supplementation (N = 39) vs. placebo (N = 40) on the expression of 5 genes in breast and adipose tissue in overweight/obese postmenopausal women (50-75 years)...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28630461/antrodia-cinnamomea-reduces-obesity-and-modulates-the-gut-microbiota-in-high-fat-diet-fed-mice
#19
C-J Chang, C-C Lu, C-S Lin, J Martel, Y-F Ko, D M Ojcius, T-R Wu, Y-H Tsai, T-S Yeh, J-J Lu, H-C Lai, J D Young
BACKGROUND: Obesity is associated with gut microbiota dysbiosis, disrupted intestinal barrier and chronic inflammation. Given the high and increasing prevalence of obesity worldwide, anti-obesity treatments that are safe, effective and widely available would be beneficial. We examined whether the medicinal mushroom Antrodia cinnamomea may reduce obesity in mice fed with a high-fat diet (HFD). METHODS: Male C57BL/6J mice were fed a HFD for eight weeks to induce obesity and chronic inflammation...
June 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28606849/genetically-modified-mesenchymal-stem-stromal-cells-transfected-with-adiponectin-gene-can-stably-secrete-adiponectin
#20
Md Murad Hossain, Malliga Raman Murali, Tunku Kamarul
AIMS: Mesenchymal stem/stromal cells (MSCs) hold promises for the treatment of diverse diseases and regeneration of injured tissues. Genetic modification of MSCs through gene delivery might enhance their therapeutic potential. Adiponectin has been appeared as a potential biomarker for predicting various diseases. Plasma adiponectin levels are negatively correlated with various metabolic and vascular diseases and supplementation of exogenous adiponectin ameliorates the diseases. This study aims to develop adiponectin secreting genetically modified MSCs (GM-MSCs) as a potent strategic tool to complement endogenous adiponectin for the treatment of adiponectin deficiency diseases...
August 1, 2017: Life Sciences
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