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Supplement AND adiponectin

Raphaël Boursereau, Michel Abou-Samra, Sophie Lecompte, Laurence Noel, Sonia M Brichard
BACKGROUND: The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease progression. The NLRP3 inflammasome plays a key role in the inflammation process, and its aberrant activation leads to several inflammatory or immune diseases. Here we investigated the expression of the NLRP inflammasome in skeletal muscle and its contribution to DMD...
March 20, 2018: BMC Biology
Yoon-Young Sung, Dong-Seon Kim, Seung-Hyung Kim, Ho Kyoung Kim
BACKGROUND: Allium fistulosum (Welsh onion) is a traditional medicinal plant used for the treatment of colds, influenza, abdominal pain, headache, and heart disease. This study evaluated the effects of A. fistulosum ethanolic extract (AFE) and aqueous extract (AFW) on body weight and other obesity-related parameters. METHODS: Male 8-week-old C57BL/6 J mice were fed either a standard chow diet (normal control) or a high-fat diet (HFD) either alone (HFD-control) or in combination with G...
March 20, 2018: BMC Complementary and Alternative Medicine
Kalaivani A, V V Sathibabu Uddandrao, Brahmanaidu Parim, Saravanan Ganapathy, Nivedha P R, Sushma Chandulee Kancharla, Rameshreddy P, Swapna K, Vadivukkarasi Sasikumar
In this study, we evaluated the ameliorative potential of Cucurbita maxima seeds oil (CSO (100 mg/kg body weight)) supplementation to high fat diet (HFD)-induced obese rats for 30 days on the changes in body weight, markers of lipid metabolism such as LDL, HDL, triglycerides, total cholesterol, adiponectin, leptin, amylase, and lipase. We also investigated the effects of CSO on the changes of lipid metabolic enzymes such as fatty-acid synthase, acetyl CoA carboxylase, carnitine palmitoyl transferase-1, HMG CoA reductase, and inflammatory markers (TNF-α and IL-6)...
March 19, 2018: Archives of Physiology and Biochemistry
Gemma Sangüesa, José Carlos Montañés, Miguel Baena, Rosa María Sánchez, Núria Roglans, Marta Alegret, Juan Carlos Laguna
PURPOSE: Sugar-sweetened beverage intake is a risk factor for insulin resistance, dyslipidemia, fatty liver, and steatohepatitis (NASH). Sub-chronic supplementation of liquid fructose, but not glucose, in female rats increases liver and plasma triglycerides without inflammation. We hypothesized that chronic supplementation of fructose would cause NASH and liver insulin resistance. METHODS: We supplemented female Sprague-Dawley rats with water or either fructose or glucose 10% w/v solutions under isocaloric conditions for 7 months...
March 7, 2018: European Journal of Nutrition
Takwa Bedhiafi, Kamel Charradi, Mouna Ben Azaiz, Mohamed Mahmoudi, Issam Msakni, Khawla Jebari, Ammar Bouziani, Ferid Limam, Ezzedine Aouani
Spleen is the largest lymphoid organ and obesity is related to an elevated risk of immunity dysfunction and the mechanism whereby fat adversely affects the spleen is poorly understood. This study was designed to assess the effectiveness of grape seed and skin extract (GSSE) and orlistat (Xenical, Xe) on high fat diet (HFD)-induced spleen lipotoxicity. Obese rats were treated either with GSSE (4 g/kg bw) or Xe (2 mg/kg bw) or GSSE + Xe and monitored for weight loss during 3 months. Animals were then sacrificed and their spleen used for the evaluation of lipotoxicity-induced oxidative stress and inflammation as well as the putative protection afforded by GSSE and Xe treatment...
March 7, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Blanca Grases-Pintó, Mar Abril-Gil, Maria J Rodríguez-Lagunas, Margarida Castell, Francisco J Pérez-Cano, Àngels Franch
At birth, when immune responses are insufficient, there begins the development of the defence capability against pathogens. Leptin and adiponectin, adipokines that are present in breast milk, have been shown to play a role in the regulation of immune responses. We report here, for the first time, the influence of in vivo adipokine supplementation on the intestinal immune system in early life. Suckling Wistar rats were daily supplemented with leptin (0·7 μg/kg per d, n 36) or adiponectin (35 μg/kg per d, n 36) during the suckling period...
March 2018: British Journal of Nutrition
Aya Mousa, Negar Naderpoor, Helena Teede, Robert Scragg, Barbora de Courten
Background: Vitamin D has been proposed to have anti-inflammatory properties; however, the effect of vitamin D supplementation on inflammation in type 2 diabetes has not been established. Objective: The aim of this systematic review and meta-analysis was to examine the effect of vitamin D supplementation on inflammatory markers in patients with type 2 diabetes and to identify relevant gaps in knowledge. Data sources: MEDLINE, CINAHL, Embase, and EBM Reviews were searched systematically from inception to January 25, 2017...
February 27, 2018: Nutrition Reviews
Sarmila Nepali, Do-Kuk Kim, Hoon-Yeon Lee, Hyeon-Hui Ki, Bo-Ram Kim, Sung-Woo Hwang, Min Park, Dae-Ki Kim, Young-Mi Lee
The present study was undertaken to investigate the anti‑obesity effect of a 50% ethanol extract of Euphorbia supina (ESEE) in high‑fat‑diet (HFD)‑induced obese C57BL/6J mice. Mice were fed a HFD with or without ESEE (2, 10, or 50 mg/kg) or with Garcinia cambogia (positive control) for 6 weeks. ESEE supplementation significantly reduced body, epididymal white adipose tissue (eWAT), and organ weights (P<0.05). ESEE also reduced hepatic steatosis and improved serum lipid profiles. In addition, ESEE significantly reduced serum leptin levels and increased adiponectin levels, and significantly downregulated the mRNA and protein levels of proliferator‑activated receptor γ (PPARγ) and CCAAT/enhancer‑binding protein alpha (C/EPBα) in eWAT and liver tissues (all P<0...
February 16, 2018: International Journal of Molecular Medicine
Jorly Mejia-Montilla, Eduardo Reyna-Villasmil, Lorena Domínguez-Brito, Carmen Naranjo-Rodríguez, Delia Noriega-Verdugo, María Padilla-Samaniego, Vanessa Vargas-Olalla
OBJECTIVE: To study plasma adiponectin levels in women diagnosed with polycystic ovary syndrome given omega-3 fatty acid supplements. PATIENTS AND METHODS: A study was conducted in 195 women diagnosed with polycystic ovary syndrome treated with omega-3 fatty acids for 12weeks (n=97; groupA) and control women given placebo (n=98, groupB). General characteristics, metabolism, lipid profile, and hormone and adiponectin levels were compared. RESULTS: There were no significant differences between the two groups in general characteristics...
February 13, 2018: Endocrinología, diabetes y nutrición
Ayodele Olufemi Morakinyo, Titilola Aderonke Samuel, Funmileyi Olubajo Awobajo, Gabriel Olorunleke Oludare, Adekunle Mofolorunso
The possible intake of folate in excess of the recommended upper levels is a matter of critical importance. This study was conducted to investigate the effects of prenatal and postnatal high folic acid supplementation (FAS) on glucose tolerance, insulin sensitivity, lipid metabolism, and expression of adiponectin in rats. The study included 20 female rats divided into two groups: control group and FAS group (receiving high folic acid supplemented diet). Both groups of female rats were mated and pregnancy confirmed...
February 16, 2018: Journal of Dietary Supplements
Edenil Costa Aguilar, Josiane Fernandes da Silva, Juliana Maria Navia-Pelaez, Alda Jusceline Leonel, Lorrayne Gonçalves Lopes, Zélia Menezes-Garcia, Adaliene Versiani Matos Ferreira, Luciano Dos Santos Aggum Capettini, Lilian G Teixeira, Virginia Soares Lemos, Jacqueline I Alvarez-Leite
OBJECTIVES: Studies suggest that sodium butyrate reduces obesity-associated inflammation and insulin resistance in in vitro and in vivo models. Apo E-/- mice have high basal oxidative stress and naturally develop dyslipidemia and atherosclerosis. Because these disorders are present in obesity, the aim of this study was to determine whether Apo E-/- mice could be a more realistic model for studying obesity and insulin resistance. METHODS: We evaluated the action of orally administered sodium butyrate on adipose tissue expansion and insulin resistance using diet-induced obese Apo E-/- mice...
March 2018: Nutrition
Alicia González-González, María Dolores Mediavilla, Emilio J Sánchez-Barceló
The objective of this article is to review the basis supporting the usefulness of melatonin as an adjuvant therapy for breast cancer (BC) prevention in several groups of individuals at high risk for this disease. Melatonin, as a result of its antiestrogenic and antioxidant properties, as well as its ability to improve the efficacy and reduce the side effects of conventional antiestrogens, could safely be associated with the antiestrogenic drugs presently in use. In individuals at risk of BC due to night shift work, the light-induced inhibition of melatonin secretion, with the consequent loss of its antiestrogenic effects, would be countered by administering this neurohormone...
February 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Anize Delfino von Frankenberg, André F Reis, Fernando Gerchman
Elevated hepatic glucose production, impaired insulin secretion, and insulin resistance - abnormalities of glucose metabolism typically found in subjects with obesity - are major factors underlying the pathogenesis of type 2 diabetes (DM2) and the metabolic syndrome (MS). Adiponectin is a major regulator of glucose and lipid homeostasis via its insulin-sensitizing properties, and lower levels seems to be associated with the development of DM2 and MS. The purpose of this review is to clarify the mechanisms whereby adiponectin relates to the development of DM2 and MS and the association between polymorphisms of the adiponectin gene, circulating levels of the hormone, and its relationships with DM2...
December 2017: Archives of Endocrinology and Metabolism
Nafiseh Sokri Mashhadi, Mehrnoosh Zakerkish, Javad Mohammadiasl, Mehdi Zarei, Majid Mohammadshahi, Mohammad Hossein Haghighizadeh
BACKGROUND AND OBJECTIVES: This randomized, placebo-controlled trial was performed for 8 weeks to investigate the potential effects of astaxanthin (AST) supplementation on the adiponectin concentration, lipid peroxidation, glycemic control, insulin sensitivity, and anthropometric indices in participants with type 2 diabetes mellitus. METHODS AND STUDY DESIGN: We enrolled 44 participants with type 2 diabetes who met our inclusion criteria. Eight milligrams of AST supplementation or a placebo were randomly administered once daily for 8 weeks to these participants...
2018: Asia Pacific Journal of Clinical Nutrition
Linjie Wang, Ke Xue, Yan Wang, Lili Niu, Li Li, Tao Zhong, Jiazhong Guo, Jing Feng, Tianzeng Song, Hongping Zhang
Objective: It is commonly accepted that adiponectin binds to its two receptors to regulate fatty acid metabolism in adipocytes. To better understand their functions in the regulation of intramuscular adipogenesis in goats, we cloned the three genes (AdipoQ, AdipoR1 and AdipoR2) encoding these proteins and detected their mRNA distribution in different tissues. We also determined the role of AdipoQ in the adipogenic differentiation of goat skeletal muscle satellite cells (SMSCs). Methods: SMSCs were isolated using 1 mg/ml Pronase E from the longissimus dorsi muscles of 3-day-old female Nanjiang brown goats...
January 30, 2018: Asian-Australasian Journal of Animal Sciences
Jingqing Chen, Xiaoshi Ma, Ying Yang, Zhaolai Dai, Zhenlong Wu, Guoyao Wu
Glycine supplementation has been reported to enhance white-fat loss and improve sensitivity to insulin in animals with obesity or type 2 diabetes. However, the underlying mechanisms responsible for the beneficial effects of glycine remain largely unknown. The purpose of this study was to test the hypothesis that glycine regulates adipocyte differentiation, adipogenesis, and lipolysis, therefore, contributing to white-fat reduction. 3T3-L1 pre-adipocytes were induced to differentiate into adipocytes in the presence of glycine (0, 0...
January 22, 2018: Amino Acids
Nora López, Juana Sánchez, Andreu Palou, Francisca Serra
Early nutrition plays an important role in development and may constitute a relevant contributor to the onset of obesity in adulthood. The aim of this study was to evaluate the long-term impact of maternal leucine (Leu) supplementation during lactation on progeny in rats. A chow diet, supplemented with 2% Leu, was supplied during lactation (21 days) and, from weaning onwards, was replaced by a standard chow diet. Then, at adulthood (6 months of age), this was replaced with hypercaloric diets (either with high-fat (HF) or high-carbohydrate (HC) content), for two months, to induce obesity...
January 12, 2018: Nutrients
Koichi Murano, Hirofumi Ogino, Tomofumi Okuno, Tomohiro Arakawa, Hitoshi Ueno
The role of supplementary selenium on the induction of insulin resistance and oxidative stress in a diabetic mouse model was investigated in NSY mice on a high fat diet (HFD) and administered seleno-L-methionine (SeMet)-containing water for 12 weeks. Significant increases in oral glucose tolerance-tested (OGTT), insulin tolerance-tested, and non-fasting blood glucose levels were observed in mice on a HFD, as well as the significant increases in OGTT and non-fasting plasma insulin levels. Mice on a HFD had decreased plasma adiponectin levels and increased free fatty acid (FFA) levels...
2018: Biological & Pharmaceutical Bulletin
Hitoshi Ueno, Ryo Shimizu, Tomofumi Okuno, Hirofumi Ogino, Tomohiro Arakawa, Koichi Murano, Katsuhiko Nakamuro
The protective effects of seleno-L-methionine (SeMet) on oxidative stress in pancreatic islets were investigated with a short-term nicotinamide (NA) and streptozotocin (STZ)-induced diabetic mouse model. ICR mice were intraperitoneally injected twice with 100 mg/kg STZ and 120 mg/kg NA at a 1-d interval and were then orally administered 158 µg Se/kg SeMet with free access to a selenium-deficient diet for 5 weeks. Administration of SeMet significantly improved the levels of glycated hemoglobin (HbA1c), non-fasting and oral glucose tolerance-tested (OGTT) blood glucose, plasma adiponectin and hepatic glycogen that deteriorated by NA/STZ treatment...
2018: Biological & Pharmaceutical Bulletin
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