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https://www.readbyqxmd.com/read/27894336/curcumin-and-long-chain-omega-3-polyunsaturated-fatty-acids-for-prevention-of-type-2-diabetes-cop-d-study-protocol-for-a-randomised-controlled-trial
#1
Rohith N Thota, Shamasunder H Acharya, Kylie A Abbott, Manohar L Garg
BACKGROUND: Lifestyle interventions, including increase in physical activity and dietary counselling, have shown the ability to prevent type 2 diabetes (T2D) in high-risk state individuals, but the prevalence is still skyrocketing in Australia, in line with global prevalence. Currently, no medicines are approved by the Therapeutic Goods Administration in Australia for the management of prediabetes. Therefore, there is a need of developing a safer, biologically efficacious and cost-effective alternative for delaying the transition of individual health state from prediabetes into T2D...
November 29, 2016: Trials
https://www.readbyqxmd.com/read/27890887/royal-jelly-improves-hyperglycemia-in-obese-diabetic-kk-ay-mice
#2
Mei Yoshida, Kaori Hayashi, Risa Watadani, Yoshiyasu Okano, Keiya Tanimura, Jun Kotoh, Daiki Sasaki, Kozo Matsumoto, Akihiko Maeda
The study examined whether royal jelly (RJ) can prevent obesity and ameliorate hyperglycemia in type 2 diabetes. This study utilized obese/diabetic KK-Ay mice. RJ (10 mg/kg) was administered by oral gavage. Body weight, plasma glucose and insulin levels were measured. mRNA and protein levels were determined using quantitative reverse transcription polymerase chain reaction and western blotting, respectively. Four weeks of RJ administration improved hyperglycemia and partially suppressed body weight gain, although the latter effect did not reach statistical significance...
November 26, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27885532/whey-protein-supplementation-enhances-body-fat-and-weight-loss-in-women-long-after-bariatric-surgery-a-randomized-controlled-trial
#3
Daniela Lopes Gomes, Milene Moehlecke, Fernanda Bassan Lopes da Silva, Eliane Said Dutra, Beatriz D'Agord Schaan, Kenia Mara Baiocchi de Carvalho
BACKGROUND: The ideal nutritional approach for weight regain after bariatric surgery remains unclear. OBJECTIVE: The objective of this study is to assess the effect of whey protein supplementation on weight loss and body composition of women who regained weight 24 or more months after bariatric surgery. METHODS: This is a 16-week open-label, parallel-group, randomized controlled trial of women who regained at least 5 % of their lowest postoperative weight after a Roux-en-Y gastric bypass (RYGB)...
November 24, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27847435/evaluation-of-fish-oil-rich-in-mufas-for-anti-diabetic-and-anti-inflammation-potential-in-experimental-type-2-diabetic-rats
#4
Waranya Keapai, Sopida Apichai, Doungporn Amornlerdpison, Narissara Lailerd
The advantages of monounsaturated fatty acids (MUFAs) on insulin resistance and type 2 diabetes mellitus (T2DM) have been well established. However, the molecular mechanisms of the anti-diabetic action of MUFAs remain unclear. This study examined the anti-hyperglycemic effect and explored the molecular mechanisms involved in the actions of fish oil- rich in MUFAs that had been acquired from hybrid catfish (Pangasius larnaudii×Pangasianodon hypophthalmus) among experimental type 2 diabetic rats. Diabetic rats that were fed with fish oil (500 and 1,000 mg/kg BW) for 12 weeks significantly reduced the fasting plasma glucose levels without increasing the plasma insulin levels...
November 2016: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/27824398/effects-of-quercetin-on-adiponectin-mediated-insulin-sensitivity-in-polycystic-ovary-syndrome-a-randomized-placebo-controlled-double-blind-clinical-trial
#5
N Rezvan, A Moini, L Janani, K Mohammad, A Saedisomeolia, M Nourbakhsh, S Gorgani-Firuzjaee, M Mazaherioun, M J Hosseinzadeh-Attar
Polycystic ovary syndrome (PCOS) is a heterogeneous, multi-causal, and genetically complex disorder, which is related to the failure in endocrine glands. Adiponectin has been reported to be low in PCOS, even in the absence of adiposity. Quercetin reduces serum glucose, insulin, triglycerides, and cholesterol levels and increases the expression and secretion of adiponectin. The aim of this study was to determine the effect of quercetin on the adiponectin-mediated insulin sensitivity in PCOS patients. Eighty-four women with PCOS were selected and randomly assigned to 2 groups of treatment and control...
November 7, 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27821167/fermented-rice-bran-supplementation-mitigates-metabolic-syndrome-in-stroke-prone-spontaneously-hypertensive-rats
#6
Md Alauddin, Hitoshi Shirakawa, Takuya Koseki, Naoko Kijima, Ardiansyah, Slamet Budijanto, Jahidul Islam, Tomoko Goto, Michio Komai
BACKGROUND: Previous study shown that enzyme treated-rice bran effectively improved hypertension and glucose intolerance in stroke-prone spontaneously hypertensive rat (SHRSP). However, dual fermentation of rice bran's efficacy against metabolic syndrome in SHRSP is still unknown. METHODS: Fermented rice bran (FRB) was prepared by dual fermentation of rice bran using fungi and lactic acid bacteria. The effect of FRB on metabolic syndrome in stroke-prone spontaneously hypertensive rats (SHRSP) was investigated by single and chronic supplementation...
November 8, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27812515/the-effect-of-onion-peel-extract-on-inflammatory-mediators-in-korean-overweight-and-obese-women
#7
Kyung-Ah Kim, Jung-Eun Yim
Quercetin, found abundantly in onion peel, has been known to have antioxidant and anti-obesity effects and improves endothelial function. The purpose of this study was to evaluate the effects of a quercetin-rich onion peel extract (OPE) on the inflammatory mediators in overweight and obese women. This study was a randomized double-blind, placebo-controlled study. Thirty-seven healthy overweight and obese women were randomly assigned to two groups, and one group was given a soft capsuled OPE (100 mg quercetin/day, n = 18) and the other group a same capsuled placebo (n = 19) for 12 weeks...
October 2016: Clinical Nutrition Research
https://www.readbyqxmd.com/read/27790335/the-effects-of-vitamin-d-supplementation-on-adiponectin-level-and-insulin-resistance-in-first-degree-relatives-of-subjects-with-type-2-diabetes-a-randomized-double-blinded-controlled-trial
#8
Seyed Mohammad Mohammadi, Seyed Ahmad Eghbali, Sedighah Soheilikhah, Saeedeh Jam Ashkezari, Maryam Salami, Mohammad Afkhami-Ardekani, Arezoo Afkhami-Ardekani
BACKGROUND: Despite the certain role of both vitamin D and adiponectin in the regulation of insulin sensitivity, the interaction between these two agents has remained uncertain. OBJECTIVE: The present study aimed to determine whether vitamin D is able to change plasma adiponectin and affect glucose homeostasis and insulin sensitivity in first-degree relatives of subjects with type 2 diabetes. METHODS: This randomized clinical trial was conducted at Clinic of Shahid Sadoughi Hospital in Yazd, Iran, from January 25, 2012 to December 25, 2014...
September 2016: Electronic Physician
https://www.readbyqxmd.com/read/27759074/acute-effects-of-a-single-dose-of-tocotrienols-on-insulinemic-and-inflammatory-responses-in-metabolic-syndrome-subjects-after-a-high-fat-challenge
#9
H-L Che, M S Kanthimathi, R Loganathan, K H Yuen, A T B Tan, K R Selvaduray, K Nesaretnam, K-T Teng
BACKGROUND/OBJECTIVES: Evidence shows that tocotrienols potentially reverse various chronic disease progressions caused by the metabolic syndrome. We aimed to investigate the acute effects of a single-dose supplementation of gamma and delta tocotrienols (γδ-T3, 1:4 ratio) compared with those in placebo on the insulinemic, anti-inflammatory and anti-thrombogenic responses in metabolic syndrome subjects. SUBJECTS/METHODS: Thirty metabolic syndrome subjects (15 men and 15 women) were recruited to a randomized, double-blinded and crossover study...
October 19, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27757271/comparative-evaluation-of-anti-obesity-effect-of-aloe-vera-and-gymnema-sylvestre-supplementation-in-high-fat-diet-fed-c57bl-6j-mice
#10
Ramesh Pothuraju, Raj Kumar Sharma, Sarver Ahmed Rather, Satvinder Singh
BACKGROUND: The aim of the present study was to investigate, anti-obesity effect of Aloe vera (AV), and Gymnema sylvestre (GS) whole extract powders administration to high-fat diet (HFD) fed C57BL/6J mice for 12 weeks. MATERIALS AND METHODS: At the end of experiment, different parameters such as body weight, feed intake, organ weights, fasting blood glucose, oral glucose tolerance test, plasma lipid levels, and expression analysis of adipocytokines were evaluated...
September 2016: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/27751666/omega-3-fatty-acids-inflammatory-status-and-biochemical-markers-of-patients-with-systemic-lupus-erythematosus-a-pilot-study
#11
Mariane Curado Borges, Fabiana de Miranda Moura Dos Santos, Rosa Weiss Telles, Marcus Vinícius Melo de Andrade, Maria Isabel Toulson Davisson Correia, Cristina Costa Duarte Lanna
BACKGROUND: Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP) and other inflammatory mediators. OBJECTIVE: To investigate the effects of omega-3 fatty acids on circulating levels of inflammatory mediators and biochemical markers in women with systemic lupus erythematosus (SLE). METHODS: Experimental clinical study (clinical trial: NCT02524795); 49 women with SLE (ACR1982/1997) were randomized: 22 to the omega-3 group (daily intake of 1080mg EPA+200mg DHA, for 12 weeks) and 27 to the control group...
September 22, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27742678/mir-181a-5p-regulates-3t3-l1-cell-adipogenesis-by-targeting-smad7-and-tcf7l2
#12
Dan Ouyang, Lifeng Xu, Lihua Zhang, Dongguang Guo, Xiaotong Tan, Xiaofang Yu, Junjie Qi, Yaqiong Ye, Qihong Liu, Yongjiang Ma, Yugu Li
MicroRNAs are highly conserved non-coding small RNAs participating in almost all kinds of biological activities. MiR-181a has been reported to be involved in the differentiation of porcine primary preadipocytes, but the profound effect of miR-181a-5p on 3T3-L1 adipocyte differentiation and proliferation is still unclear. In this study, we found that supplementation of miR-181a-5p in 3T3-L1 cells significantly promoted the adipogenesis and inhibited cell proliferation with increased expression of adipogenic marker genes including peroxisome proliferator-activated receptor gamma (Pparγ), CCAAT/enhancer-binding protein alpha (C/ebpα), fatty acid-binding protein 4 (Fabp4), and Adiponectin, accompanied by an accumulation of lipid droplet, an increase of triglyceride content, and a decrease of cell proliferation...
October 14, 2016: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/27721230/potential-effects-of-omega-3-fatty-acids-on-insulin-resistance-and-lipid-profile-in-maintenance-hemodialysis-patients-a-randomized-placebo-controlled-trial
#13
Afshin Gharekhani, Simin Dashti-Khavidaki, Mahboob Lessan-Pezeshki, Mohammad-Reza Khatami
INTRODUCTION: Insulin resistance (IR), a risk factor for cardiovascular disease and all-cause mortality, is prevalent among maintenance hemodialysis patients. Effects of omega-3 fatty acids on IR in hemodialysis patients have not been well understood. This study aimed to determine the effects of omega-3 fatty acids on IR and serum lipids of hemodialysis patients. MATERIALS AND METHODS: Fifty-four adult patients on hemodialysis were randomly assigned to receive either 1800 mg of omega-3 fatty acids or placebo daily for 4 months...
September 2016: Iranian Journal of Kidney Diseases
https://www.readbyqxmd.com/read/27698957/corn-silk-extract-improves-cholesterol-metabolism-in-c57bl-6j-mouse-fed-high-fat-diets
#14
Jae Hoon Cha, Sun Rim Kim, Hyun Joong Kang, Myung Hwan Kim, Ae Wha Ha, Woo Kyoung Kim
BACKGROUND/OBJECTIVES: Corn silk (CS) extract contains large amounts of maysin, which is a major flavonoid in CS. However, studies regarding the effect of CS extract on cholesterol metabolism is limited. Therefore, the purpose of this study was to determine the effect of CS extract on cholesterol metabolism in C57BL/6J mouse fed high-fat diets. MATERIALS/METHODS: Normal-fat group fed 7% fat diet, high-fat (HF) group fed 25% fat diet, and high-fat with corn silk (HFCS) group were orally administered CS extract (100 mg/kg body weight) daily...
October 2016: Nutrition Research and Practice
https://www.readbyqxmd.com/read/27678302/adiponectin-protects-the-rats-liver-against-chronic-intermittent-hypoxia-induced-injury-through-amp-activated-protein-kinase-pathway
#15
Wenxiao Ding, Qiang Zhang, Yanbin Dong, Ning Ding, Hanpeng Huang, Xianji Zhu, Sean Hutchinson, Xingya Gao, Xilong Zhang
This study was performed to assess the effect of chronic intermittent hypoxia (CIH) on the liver, the associated mechanisms and the potential therapeutic roles of adiponectin (Ad). Sixty rats were randomly assigned to four groups: the normal control (NC), NC and Ad supplement (NC + Ad), CIH, and CIH and Ad supplement (CIH + Ad) groups. The rats in the CIH and CIH + Ad groups were exposed to a hypoxic environment for 4 months. Rats in the NC + Ad and CIH + Ad groups were also treated with an intravenous injection of Ad (10 ug), twice a week...
September 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27667474/wogonin-enhances-intracellular-adiponectin-levels-and-suppresses-adiponectin-secretion-in-3t3-l1-adipocytes
#16
Tan Yang, Hua Liu, Bo Zhao, Zhongyuan Xia, Yemin Zhang, Deling Zhang, Mingxin Li, Yingkang Cao, Zhijiang Zhang, Yongyi Bi, Changhua Wang
As an insulin sensitizer and modulator of inflammatory responses, adiponectin has become a therapeutic target for insulin resistance, diabetes, and diabetes-related complications. Wogonin possesses anti-oxidative, anti-inflammatory, and anti-diabetic abilities. However, its effect on generation and secretion of adiponectin is ill-defined in adipocytes. Here, we demonstrated that wogonin administration augmented intracellular adiponectin levels and attenuated adiponectin release in a dose- and time-dependent manner in mature 3T3-L1 adipocytes, along with a suppression of PKCδ phosphorylation...
September 21, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27600055/green-tea-extract-and-catechol-o-methyltransferase-genotype-modify-the-post-prandial-serum-insulin-response-in-a-randomised-trial-of-overweight-and-obese-post-menopausal-women
#17
A M Dostal, A Arikawa, L Espejo, S Bedell, M S Kurzer, N R Stendell-Hollis
BACKGROUND: Green tea extract (GTE) may be involved in a favourable post-prandial response to high-carbohydrate meals. The catechol-O-methyltransferase (COMT) genotype may modify these effects. We examined the acute effects of GTE supplementation on the post-prandial response to a high-carbohydrate meal by assessing appetite-associated hormones and glucose homeostasis marker concentrations in women who consumed 843 mg of (-)-epigallocatechin-3-gallate (EGCG) or placebo capsules for 11-12 months...
September 7, 2016: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/27589792/platycodon-grandiflorus-root-extract-attenuates-body-fat-mass-hepatic-steatosis-and-insulin-resistance-through-the-interplay-between-the-liver-and-adipose-tissue
#18
Ye Jin Kim, Ji-Young Choi, Ri Ryu, Jeonghyeon Lee, Su-Jung Cho, Eun-Young Kwon, Mi-Kyung Lee, Kwang-Hyeon Liu, Yu Rina, Mi-Kyung Sung, Myung-Sook Choi
The Platycodon grandiflorus root, a Korean medicinal food, is well known to have beneficial effects on obesity and diabetes. In this study, we demonstrated the metabolic effects of P. grandiflorus root ethanol extract (PGE), which is rich in platycodins, on diet-induced obesity. C57BL/6J mice (four-week-old males) were fed a normal diet (16.58% of kilocalories from fat), high-fat diet (HFD, 60% of kilocalories from fat), and HFD supplemented with 5% (w/w) PGE. In the HFD-fed mice, PGE markedly suppressed the body weight gain and white fat mass to normal control level, with simultaneous increase in the expression of thermogenic genes (such as SIRT1, PPARα, PGC1α, and UCP1), that accompanied changes in fatty acid oxidation (FAO) and energy expenditure...
2016: Nutrients
https://www.readbyqxmd.com/read/27580020/mulberry-anthocyanin-extract-ameliorates-insulin-resistance-by-regulating-pi3k-akt-pathway-in-hepg2-cells-and-db-db-mice
#19
Fujie Yan, Guanhai Dai, Xiaodong Zheng
This study evaluated the capacity of mulberry anthocyanin extract (MAE) on insulin resistance amelioration in HepG2 cells induced by high glucose and palmitic acid and diabetes-related metabolic changes in type 2 diabetic mice. In vitro, MAE alleviated insulin resistance in HepG2 cells and increased glucose consumption, glucose uptake and glycogen content. Enzyme activities of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) were decreased due to PPARγ coactivator 1α (PGC-1α) and forkhead box protein O1 (FOXO1) inhibition...
October 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27575873/dietary-fisetin-supplementation-protects-against-alcohol-induced-liver-injury-in-mice
#20
Qian Sun, Wenliang Zhang, Wei Zhong, Xinguo Sun, Zhanxiang Zhou
BACKGROUND: Overproduction of reactive oxygen species is associated with the development of alcoholic liver disease (ALD). Plant polyphenols have been used as dietary interventions for multiple diseases including ALD. The objective of this study was to determine whether dietary supplementation with fisetin, a novel flavonoid, exerts beneficial effect on alcohol-induced liver injury. METHODS: C57BL/6J mice were pair-fed with the Lieber-DeCarli control or ethanol (EtOH) diet for 4 weeks with or without fisetin supplementation at 10 mg/kg/d...
October 2016: Alcoholism, Clinical and Experimental Research
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