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https://www.readbyqxmd.com/read/29329236/gender-associated-impact-of-early-leucine-supplementation-on-adult-predisposition-to-obesity-in-rats
#1
Nora López, Juana Sánchez, Andreu Palou, Francisca Serra
Early nutrition plays an important role in development and may constitute a relevant contributor to the onset of obesity in adulthood. The aim of this study was to evaluate the long-term impact of maternal leucine (Leu) supplementation during lactation on progeny in rats. A chow diet, supplemented with 2% Leu, was supplied during lactation (21 days) and, from weaning onwards, was replaced by a standard chow diet. Then, at adulthood (6 months of age), this was replaced with hypercaloric diets (either with high-fat (HF) or high-carbohydrate (HC) content), for two months, to induce obesity...
January 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29311488/role-of-supplementary-selenium-on-the-induction-of-insulin-resistance-and-oxidative-stress-in-nsy-mice-fed-a-high-fat-diet
#2
Koichi Murano, Hirofumi Ogino, Tomofumi Okuno, Tomohiro Arakawa, Hitoshi Ueno
The role of supplementary selenium on the induction of insulin resistance and oxidative stress in a diabetic mouse model was investigated in NSY mice on a high fat diet (HFD) and administered seleno-L-methionine (SeMet)-containing water for 12 weeks. Significant increases in oral glucose tolerance-tested (OGTT), insulin tolerance-tested, and non-fasting blood glucose levels were observed in mice on a HFD, as well as the significant increases in OGTT and non-fasting plasma insulin levels. Mice on a HFD had decreased plasma adiponectin levels and increased free fatty acid (FFA) levels...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29311486/effect-of-seleno-l-methionine-on-oxidative-stress-in-the-pancreatic-islets-of-a-short-term-induced-diabetic-mouse-model-in-insufficient-selenium-status
#3
Hitoshi Ueno, Ryo Shimizu, Tomofumi Okuno, Hirofumi Ogino, Tomohiro Arakawa, Koichi Murano, Katsuhiko Nakamuro
The protective effects of seleno-L-methionine (SeMet) on oxidative stress in pancreatic islets were investigated with a short-term nicotinamide (NA) and streptozotocin (STZ)-induced diabetic mouse model. ICR mice were intraperitoneally injected twice with 100 mg/kg STZ and 120 mg/kg NA at a 1-d interval and were then orally administered 158 µg Se/kg SeMet with free access to a selenium-deficient diet for 5 weeks. Administration of SeMet significantly improved the levels of glycated hemoglobin (HbA1c), non-fasting and oral glucose tolerance-tested (OGTT) blood glucose, plasma adiponectin and hepatic glycogen that deteriorated by NA/STZ treatment...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29299989/curcuminoids-plus-piperine-modulate-adipokines-in-type-2-diabetes-mellitus
#4
Amirhossein Sahebkar, Yunes Panahi, Nahid Khalili, Ebrahim Sahebi, Soha Namazi, Stephen L Atkin, Muhammed Majeed
OBJECTIVE: Curcumin is a naturally occurring polyphenol derived from tumeric that has been reported to have anti-inflammatory properties with effects on adipokine and ghrelin levels. Adiponectin, leptin and ghrelin modulate energy homeostasis but each have modulatory effects on inflammatory cytokines and the immune system. Therefore this analysis was performed to investigate the effect of curcumin on adiponectin, leptin and ghrelin. METHODS: A double blind randomised control trial comparing curcumin 1000mg with 10mg of piperine daily to placebo over a 12 week period...
January 3, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29290444/milk-from-cows-fed-a-diet-with-a-high-forage-concentrate-ratio-improves-inflammatory-state-oxidative-stress-and-mitochondrial-function-in-rats
#5
Gina Cavaliere, Giovanna Trinchese, Nadia Musco, Federico Infascelli, Chiara De Filippo, Vincenzo Mastellone, Valeria Maria Morittu, Pietro Lombardi, Raffaella Tudisco, Micaela Grossi, Vincenzo Monda, Monica I Cutrignelli, Antonietta Messina, Serena Calabrò, Heleena B Moni, Luigi Stradella, Giovanni Messina, Marcellino Monda, Marianna Crispino, Maria Pina Mollica
Excessive energy intake may evoke complex biochemical processes characterized by inflammation, oxidative stress, and impairment of mitochondrial function that represent the main factors underlying noncommunicable diseases. Because cow milk is widely used for human nutrition and in food industry processing, the nutritional quality of milk is of special interest with respect to human health. In our study, we analyzed milk produced by dairy cows fed a diet characterized by a high forage:concentrate ratio (high forage milk, HFM)...
December 28, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29274979/effects-of-prepartum-dietary-cation-anion-difference-and-source-of-vitamin-d-in-dairy-cows-vitamin-d-mineral-and-bone-metabolism
#6
R M Rodney, N Martinez, E Block, L L Hernandez, P Celi, C D Nelson, J E P Santos, I J Lean
Pregnant Holstein cows, 28 nulliparous and 51 parous, were blocked by parity and milk yield and randomly allocated to receive diets that differed in dietary cation-anion difference (DCAD), +130 or -130 mEq/kg, and supplemented with either calcidiol or cholecalciferol at 3 mg/11 kg of dry matter from 255 d of gestation until parturition. Blood was sampled thrice weekly prepartum, and on d 0, 1, 2, 3, 6, 9, 12, 15, 18, 21, 24, 27, and 30 postpartum to evaluate effects of the diets on vitamin D, mineral and bone metabolism, and acid-base status...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29207025/anti-obesity-effects-of-pectinase-and-cellulase-enzyme%C3%A2-treated-ecklonia%C3%A2-cava-extract-in-high%C3%A2-fat-diet%C3%A2-fed-c57bl-6n-mice
#7
In-Hye Kim, Jung-Wook Choi, Min-Kyeong Lee, Chang-Ju Kwon, Taek-Jeong Nam
The present study investigated the anti‑obesity effects of enzyme‑treated Ecklonia cava extract (EEc) in C57BL/6N mice with high‑fat diet (HFD)‑induced obesity. The EEc was separated and purified with the digestive enzymes pectinase (Rapidase X‑Press L) and cellulase (Rohament CL) and its effects on the progression of HFD‑induced obesity were examined over 10 weeks. The mice were divided into 6 groups (n=10/group) as follows: Normal diet group, HFD group, mice fed a HFD with 25 mg/kg/day Garcinia cambogia extract and mice fed a HFD with 5, 25 or 150 mg/kg/day EEc (EHD groups)...
November 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29206172/melatonin-efficacy-in-obese-leptin-deficient-mice-heart
#8
Alessandra Stacchiotti, Gaia Favero, Lorena Giugno, Igor Golic, Aleksandra Korac, Rita Rezzani
Cardiomyocytes are particularly sensitive to oxidative damage due to the link between mitochondria and sarcoplasmic reticulum necessary for calcium flux and contraction. Melatonin, important indoleamine secreted by the pineal gland during darkness, also has important cardioprotective properties. We designed the present study to define morphological and ultrastructural changes in cardiomyocytes and mainly in mitochondria of an animal model of obesity (ob/ob mice), when treated orally or not with melatonin at 100 mg/kg/day for 8 weeks (from 5 up to 13 week of life)...
December 5, 2017: Nutrients
https://www.readbyqxmd.com/read/29176994/antiobesity-potential-of-piperonal-promising-modulation-of-body-composition-lipid-profiles-and-obesogenic-marker-expression-in-hfd-induced-obese-rats
#9
Balaji Meriga, Brahmanaidu Parim, Venkata Rao Chunduri, Ramavat Ravindar Naik, Harishankar Nemani, Pothani Suresh, Saravanan Ganapathy, Satthi Babu Vvu
Background: Black pepper or Piper nigrum is a well-known spice, rich in a variety of bioactive compounds, and widely used in many cuisines across the world. In the Indian traditional systems of medicine, it is used to treat gastric and respiratory ailments. The purpose of this investigation is to study the antihyperlipidemic and antiobesity effects of piperonal in high-fat diet (HFD)-induced obese rats. Methods: Piperonal, an active constituent of Piper nigrum seeds, was isolated and confirmed by HPLC, 1H and 13C NMR spectroscopy...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29173690/omega-3-fatty-acids-inflammatory-status-and-biochemical-markers-of-patients-with-systemic-lupus-erythematosus-a-pilot-study
#10
Mariane Curado Borges, Fabiana de Miranda Moura Dos Santos, Rosa Weiss Telles, Marcus Vinícius Melo de Andrade, Maria Isabel Toulson Davisson Correia, Cristina Costa Duarte Lanna
BACKGROUND: Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP) and other inflammatory mediators. OBJECTIVE: To investigate the effects of omega-3 fatty acids on circulating levels of inflammatory mediators and biochemical markers in women with systemic lupus erythematosus (SLE). METHODS: Experimental clinical study (clinical trial: NCT02524795); 49 women with SLE (ACR1982/1997) were randomized: 22 to the omega-3 group (daily intake of 1080mg EPA+200mg DHA, for 12 weeks) and 27 to the control group...
November 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/29173649/an-obesogenic-diet-enriched-with-blue-mussels-protects-against-weight-gain-and-lowers-cholesterol-levels-in-c57bl-6-mice
#11
Hitesh B Vaidya, Surendiran Gangadaran, Sukhinder K Cheema
Obesity is linked to several health complications, such as cardiovascular disease, insulin resistance, and hypertension. Dyslipidemia in obesity is one of the prime causes for health complications. We have previously shown that blue mussels (BM) are a rich source of omega (n)-3 polyunsaturated fatty acids (PUFA) and increase the mRNA expression of peroxisome-proliferator activated receptor and adiponectin, thereby inducing anti-obesity and insulin sensitizing effects in vitro. However, the in vivo effects of BM on obesity and metabolic regulation are not known...
October 2017: Nutrition Research
https://www.readbyqxmd.com/read/29142618/melatonin-supplementation-lowers-oxidative-stress-and-regulates-adipokines-in-obese-patients-on-a-calorie-restricted-diet
#12
Karolina Szewczyk-Golec, Paweł Rajewski, Marcin Gackowski, Celestyna Mila-Kierzenkowska, Roland Wesołowski, Paweł Sutkowy, Marta Pawłowska, Alina Woźniak
Obesity is one of the major global health problems. Melatonin deficiency has been demonstrated to correlate with obesity. The aim of the study was to estimate the effect of melatonin on oxidative stress and adipokine levels in obese patients on a calorie-restricted diet. Thirty obese patients were supplemented with a daily dose of 10 mg of melatonin (n = 15) or placebo (n = 15) for 30 days with a calorie-restricted diet. Serum levels of melatonin, 4-hydroxynonenal (HNE), adiponectin, omentin-1, leptin, and resistin, as well as erythrocytic malondialdehyde (MDA) concentration and Zn/Cu-superoxide dismutase, catalase, and glutathione peroxidase (GPx) activities, were measured at baseline and after supplementation...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29113747/differential-effects-of-epa-dpa-and-dha-on-cardio-metabolic-risk-factors-in-high-fat-diet-fed-mice
#13
Xiao-Fei Guo, Andrew J Sinclair, Gunveen Kaur, Duo Li
The aim of the present study was to assess and compare the effects of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) supplementation on lipid metabolism in 4 month-old male C57BL/6J mice fed a high-fat diet. The high-fat fed mice showed evidence of fatty liver, obesity and insulin resistance after being on the high-fat diet for 6 weeks compared with the control low-fat diet fed mice. Supplementation of the high-fat diet with either EPA, DPA or DHA prevented the fatty liver, prevented high serum cholesterol and serum glucose and prevented high liver cholesterol levels...
September 22, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29111889/the-combined-effects-of-exercise-diet-and-a-multi-ingredient-dietary-supplement-on-body-composition-and-adipokine-changes-in-overweight-adults
#14
Shawn M Arent, Alan J Walker, Joseph K Pellegrino, David J Sanders, Bridget A McFadden, Tim N Ziegenfuss, Hector L Lopez
BACKGROUND: Very few weight and fat loss supplements undergo finished-product research to examine efficacy. The purpose of this study was to determine the effects of an 8-week diet and exercise program on body composition, hip and waist girth, and adipokines and evaluate whether a dietary supplement containing raspberry ketone, capsaicin, caffeine, garlic, and Citrus aurantium enhanced outcomes. METHODS: Overweight men and women completed this randomized, placebo-controlled, double-blind study...
November 7, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29105398/oral-quercetin-supplementation-enhances-adiponectin-receptor-transcript-expression-in-polycystic-ovary-syndrome-patients-a-randomized-placebo-controlled-double-blind-clinical-trial
#15
Neda Rezvan, Ashraf Moini, Sattar Gorgani-Firuzjaee, Mohammad Javad Hosseinzadeh-Attar
OBJECTIVES: Polycystic ovary syndrome (PCOS), an ovarian-pituitary axis androgen disorder, is a common endocrine disease in women. Obesity-induced androgenesis and imbalance of adipokine secretion may lead to some metabolic features of PCOS. The beneficial effects of polyphenolic compounds such as quercetin have been reported, however, the underlying molecular mechanism is not entirely understood. In the present study, we investigated the effect of quercetin supplementation on the expression of adiponectin receptors at the transcript level in peripheral blood mononuclear cells (PBMC) samples of PCOS patients...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29101812/the-effect-of-ketorolac-and-triamcinolone-acetonide-on-adipogenic-and-hepatogenic-differentiation-through-mirnas-16-15-195-possible-clinical-application-in-regenerative-medicine
#16
Sedigheh Fekri Aval, Nosratollah Zarghami, Effat Alizadeh, Seyed Abolghasem Mohammadi
OBJECTIVE: The role of miR-16/15b/195 and complementary compounds in the commitment of mesenchymal stem cells (MSCs) to different lineages is unknown. The aim of this work was to investigate the effect of ketorolac and triamcinolone acetonide on adipogenic and hepatogenic processes, respectively. Also, miR-16/15 and miR-195 expression levels were evaluated under different induction conditions. METHODS: MSCs were isolated, expanded and directed using adipogenesis medium or medium supplemented with ketorolac, and also subjected to hepatogenic differentiation using a cocktail of hepatocyte growth factor (HGF) and Oncostatin M (OSM) either with or without triamcinolone acetonide...
November 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29098530/adiponectin-attenuates-streptozotocin-induced-tau-hyperphosphorylation-and-cognitive-deficits-by-rescuing-pi3k-akt-gsk-3%C3%AE-pathway
#17
Zhi-Peng Xu, Guo-Sheng Gan, Yu-Min Liu, Jin-Song Xiao, Han-Xing Liu, Bin Mei, Jun-Jian Zhang
Clinical studies have demonstrated that decreased adiponectin is associated with the development of Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). We focused on determining the neuroprotective effect offered by adiponectin against streptozotocin-induced brain damage in ICV-STZ rat model. We found that adiponectin supplements significantly restored the cognitive deficits in ICV-STZ rat model including shorter escape latency, more crossing times and increased time spent in the target quadrant. Adiponectin supplements also increased number of dendritic branches and mushroom percentage...
November 2, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29091879/protective-effect-of-the-hydroalcoholic-extract-of-tripodanthus-acutifolius-in-hypercholesterolemic-wistar-rats
#18
Ritiéle Pinto Coelho, Denise Lima Feksa, Patrícia Martinez Oliveira, Angélica Aparecida da Costa Güllich, Bruna Cocco Pilar, Jacqueline da Costa Escobar Piccoli, Vanusa Manfredini
Cardiovascular disease (CVD) are a major public health problem, as they are among the leading causes of mortality worldwide. Tripodanthus acutifolius (TA) is a hemiparasite plant used for medicinal purposes with great antioxidant capacity. However, little is known about its hypolipemic effect. Thus, the aim of this study was to evaluate the effects of the hydroalcoholic extract of Tripodanthus acutifolius leaves in hypercholesterolemic Wistar rats. The animals were divided into: (1) NC (Normocaloric Control); (2) HC (Hypercaloric Control); (3) Oral Simvastatin Suspension 10mg/kg (SIM); (4) TA extract 50mg/kg (TA 50mg/kg) and (5) TA 100mg/kg...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29090980/dolichos-lablab-protects-against-nonalcoholic-fatty-liver-disease-in-mice-fed-high-fat-diets
#19
A-Rang Im, Yun Hee Kim, Young Hwa Kim, Won-Kyung Yang, Seung Hyung Kim, Kwang Hoon Song
Hyacinth bean, Dolichos lablab or Lablab purpureus, has been used for centuries in India and China as an edible pod and animal forage, as well as to treat diarrhea and other gastrointestinal disease in traditional Korean medicine. Recently, we have demonstrated that D. lablab extract (DLL-Ex) prevented free fatty acid-induced lipid accumulation in an in vitro cellular nonalcoholic fatty liver disease (NAFLD) model. In this study, we, thus, aimed at clarifying the hepatoprotective effects of DLL-Ex in a high-fat diet-induced in vivo animal NAFLD model, as well as at elucidating underlying mechanisms of identified effects...
December 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29067068/therapeutic-benefits-of-green-tea-extract-on-various-parameters-in-non-alcoholic-fatty-liver-disease-patients
#20
Mazhar Hussain, Habib-Ur-Rehman, Lubna Akhtar
BACKGROUND AND OBJECTIVE: NAFLD affecting up to 30% of the population globally. Drug treatment options are limited with disappointing results. The dietary supplementation in the form of green tea is another option. Our objective was toinvestigate the effect of Green tea extract (GTE) supplementation on various parameters innon-alcoholicfatty liver disease (NAFLD) patients. METHODS: This study was conducted Dept. of Medicineof Sheikh Zayed Medical College/Hospital, Rahim Yar Khan from 15 April 2016 to 15 July 2016...
July 2017: Pakistan Journal of Medical Sciences Quarterly
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