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Supplement AND adiponectin

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https://www.readbyqxmd.com/read/28630461/antrodia-cinnamomea-reduces-obesity-and-modulates-the-gut-microbiota-in-high-fat-diet-fed-mice
#1
C-J Chang, C-C Lu, C-S Lin, J Martel, Y-F Ko, D M Ojcius, T-R Wu, Y-H Tsai, T-S Yeh, J-J Lu, H-C Lai, J D Young
BACKGROUND: Obesity is associated with gut microbiota dysbiosis, disrupted intestinal barrier and chronic inflammation. Given the high and increasing prevalence of obesity worldwide, anti-obesity treatments that are safe, effective and widely available would be beneficial. We examined whether the medicinal mushroom Antrodia cinnamomea may reduce obesity in mice fed with a high-fat diet (HFD). METHODS: Male C57BL/6J mice were fed a HFD for eight weeks to induce obesity and chronic inflammation...
June 20, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28606849/genetically-modified-mesenchymal-stem-stromal-cells-transfected-with-adiponectin-gene-can-stably-secrete-adiponectin
#2
Md Murad Hossain, Malliga Raman Murali, Tunku Kamarul
AIMS: Mesenchymal stem/stromal cells (MSCs) hold promises for the treatment of diverse diseases and regeneration of injured tissues. Genetic modification of MSCs through gene delivery might enhance their therapeutic potential. Adiponectin has been appeared as a potential biomarker for predicting various diseases. Plasma adiponectin levels are negatively correlated with various metabolic and vascular diseases and supplementation of exogenous adiponectin ameliorates the diseases. This study aims to develop adiponectin secreting genetically modified MSCs as a potent strategic tool to complement endogenous adiponectin for the treatment of adiponectin deficiency diseases...
June 9, 2017: Life Sciences
https://www.readbyqxmd.com/read/28587203/effect-of-n-3-polyunsaturated-fatty-acid-supplementation-on-metabolic-and-inflammatory-biomarkers-in-type-2-diabetes-mellitus-patients
#3
M Gorety Jacobo-Cejudo, Roxana Valdés-Ramos, Ana L Guadarrama-López, Rosa-Virgen Pardo-Morales, Beatriz E Martínez-Carrillo, Laurence S Harbige
BACKGROUND: Type 2 diabetes mellitus (T2DM) is accompanied by chronic low-grade inflammation, with an imbalance in the secretion of adipokines and, worsening insulin resistance. Supplementation with n-3 PUFA in T2DM decreases inflammatory markers, the purpose of the study was to investigate the effect of n-3 PUFA supplementation on adipokines, metabolic control, and lipid profile in T2DM Mexican adults. METHODS: In a randomized, single-blind, placebo-controlled pilot study, 54 patients with T2DM received 520 mg of DHA + EPA-enriched fish-oil (FOG) or a placebo (PG) daily...
June 3, 2017: Nutrients
https://www.readbyqxmd.com/read/28578257/melatonin-supplementation-plus-exercise-behavior-ameliorate-insulin-resistance-hypertension-and-fatigue-in-a-rat-model-of-type-2-diabetes-mellitus
#4
Md Mahbubur Rahman, Han-Sol Kwon, Myung-Jin Kim, Hyeon-Kyu Go, Min-Ho Oak, Do-Hyung Kim
INTRODUCTION: The objective was to investigate the effects of melatonin and exercise on insulin resistance (IR), hypertension and fatigue syndrome in a rat model of type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Rats were divided into 5 groups namely normal control (NC), T2DM control group (DC), diabetes plus exercise (DE), diabetes plus oral melatonin supplement (DM) and diabetes plus melatonin and exercise (DME) groups. Melatonin was administered orally 5mg/kg twice daily and 40min swimming/day 5days/week were regimented after diabetes induction...
June 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28578061/effects-of-the-combination-of-%C3%AF-3-pufas-and-proanthocyanidins-on-the-gut-microbiota-of-healthy-rats
#5
Sara Ramos-Romero, Mercè Hereu, Eunice Molinar-Toribio, María Pilar Almajano, Lucía Méndez, Isabel Medina, Núria Taltavull, Marta Romeu, Maria Rosa Nogués, Josep Lluís Torres
ω-3 Polyunsaturated fatty acids (PUFAs) reduce risk factors for cardiovascular diseases (CVD) and other pathologies that involve low-grade inflammation. They have recently been shown to exert complementary functional effects with proanthocyanidins. As the reduction of health-promoting gut bacteria such as lactobacilli and bifidobacteria has been linked to a number of alterations in the host, the aim of this study was to determine whether PUFAs and proanthocyanidins also cooperate in maintaining well-balanced microbiota...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28566583/bergamottin-promotes-adipocyte-differentiation-and-inhibits-tumor-necrosis-factor-%C3%AE-induced-inflammatory-cytokines-induction-in-3t3-l1-cells
#6
Hideya Mizuno, Tomoko Hatano, Ayako Taketomi, Mami Kawabata, Toshikatsu Nakabayashi
 Nowadays, a lot of food ingredients are marketed as dietary supplements for health. Because the effectiveness and mechanisms of these compounds have not been fully characterized, they might have unknown functions. Therefore, we investigated the effect of several food ingredients (Bergamottin, Chrysin, L-Citrulline and β-Carotene) known as health foods on adipocyte differentiation by using 3T3-L1 preadipocytes. In this study, we found that Bergamottin, a furanocoumarin isolated from grapefruit juice, promotes adipocyte differentiation...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28556504/effects-of-conjugated-linoleic-acid-supplementation-on-serum-c-reactive-protein-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#7
REVIEW
Mohsen Mazidi, Ehsan Karimi, Peyman Rezaie, Gordon A Ferns
AIM: To undertake a systematic review and meta-analysis of prospective studies to determine the effect of conjugated linoleic acids (CLAs) supplementation on serum C-reactive protein (CRP). METHOD: PubMed-Medline, Web of Science, Cochrane Database and Google Scholar databases were searched (up until May 2016) to identify prospective studies evaluating the impact of CLAs supplementation on serum CRP. Random effects models meta-analysis was used for quantitative data synthesis...
May 29, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28496349/effect-of-vitamin-k-supplementation-on-insulin-sensitivity-a-meta-analysis
#8
Naeti Suksomboon, Nalinee Poolsup, Htoo Darli Ko Ko
OBJECTIVE: To perform a systematic review and meta-analysis of randomized, placebo-controlled trials to assess the effect of vitamin K supplementation on insulin sensitivity. DATA SOURCES: MEDLINE, the Cochrane Library, CINAHL, Web of Science, Scopus, clinicaltrials.gov, and clinicaltrialresults.org were searched up to January 2017. Reference lists of related papers were also scanned. STUDY SELECTION: Randomized controlled trials were selected if they compared vitamin K supplementation with placebo or no treatment and reported homeostasis model assessment of insulin resistance, fasting plasma glucose, fasting plasma insulin, C-reactive protein, adiponectin, leptin, or interleukin-6 levels...
2017: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/28486193/wogonin-mitigates-nonalcoholic-fatty-liver-disease-via-enhancing-ppar%C3%AE-adipor2-in-vivo-and-in-vitro
#9
Jing Chen, Jie Liu, Ye Wang, Xuemei Hu, Feng Zhou, Yimeng Hu, Yin Yuan, Yancheng Xu
Wogonin has been reported to attenuate hyperglycemia in diabetic mice via anti-adipogenic effect on adipocytes. The potential therapeutic role of wogonin in nonalcoholic fatty liver disease (NAFLD) remains obscure. The aim of the present study was to explore the protective effect of wogonin on NAFLD mice and cultured NCTC 1469 cells exposed to palmitate. Wogonin supplementation significantly improved metabolic parameters in NAFLD mice, including body weight, blood glucose, insulin resistance, adiponectin, blood lipids, aminotransferases and hepatic histopathology...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28475159/acute-vitamin-d%C3%A2-supplementation-in-severe-obesity-evaluation-of-multimeric-adiponectin
#10
Stefania Mai, Gillian E Walker, Roberta Vietti, Stefania Cattaldo, Chiara Mele, Lorenzo Priano, Alessandro Mauro, Gianni Bona, Gianluca Aimaretti, Massimo Scacchi, Paolo Marzullo
Obesity predisposes to vitamin D deficiency (VDD) and glucose abnormalities. It is currently debated if vitamin D administration may improve glucose homeostasis by interacting with modulators of insulin sensitivity, such as adiponectin and its oligomers. In a 4-week inpatient study on a metabolic rehabilitation program, consisting of individualized caloric restriction and aerobic physical exercise in obese subjects with VDD, we assessed the acute effects of 600,000 IU cholecalciferol given per os VD group, 12 subjects; body mass index (BMI) 42...
May 5, 2017: Nutrients
https://www.readbyqxmd.com/read/28463682/potential-therapeutic-action-of-adiponectin-in-duchenne-muscular-dystrophy
#11
Michel Abou-Samra, Raphaël Boursereau, Sophie Lecompte, Laurence Noel, Sonia M Brichard
Adiponectin (ApN) is a hormone that exhibits anti-inflammatory effects on skeletal muscle exposed to acute and chronic inflammation. We have previously tested the implication of ApN in Duchenne muscular dystrophy (DMD) using mdx mice, a model of DMD, and by generating transgenic mdx mice overexpressing ApN. We showed that ApN can act as a preventive agent and delay disease progression by reducing muscle inflammation/injury and improving force/myogenesis. Herein, we took an opposite approach and crossed mdx mice with ApN knockout mice, to obtain mdx mice with ApN depletion...
July 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28429286/effects-of-selenium-supplementation-on-the-diabetic-condition-depend-on-the-baseline-selenium-status-in-kkay-mice
#12
Novian Febiyanto, Chiho Yamazaki, Satomi Kameo, Dian K Sari, Irma M Puspitasari, Deni K Sunjaya, Dewi M D Herawati, Gaga I Nugraha, Toshio Fukuda, Hiroshi Koyama
Oxidative stress in obesity leads to insulin resistance in type 2 diabetes. Some selenoproteins possess antioxidant properties, suggesting that selenium (Se) may protect against type 2 diabetes; however, evidence from epidemiological studies is contradictory. We hypothesized that Se status before supplementation (baseline) contributes to the supplementation outcome. This study aimed to clarify the influence of baseline Se status on the effect of Se supplementation on the diabetic condition. Six-week-old KKAy mice were fed a diet without supplemental Se or with 0...
April 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28411010/effects-of-vitamin-d-and-resveratrol-on-metabolic-associated-markers-in-liver-and-adipose-tissue-from-samp8-mice
#13
Yehua Rui, Jinbo Cheng, Liqiang Qin, Cheng Shan, Jie Chang, Guiping Wang, Zhongxiao Wan
SAMP8 mice exhibit multiple metabolic characteristics associated with age, and it is a suitable candidate for researching aging associated metabolic dysfunction. OBJECTIVES: We aimed to 1) explore how key metabolic markers will be altered in both liver and adipose tissue with aging in SAMP8 mice; and 2) how the combination of vitamin D (VD) with resveratrol (RSV) will affect aging associated metabolic impairment in liver and adipose tissue from SAMP8 mice. METHODS: SAMP8 mice and their control SAMR1 mice were divided into 5 groups, i...
July 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28406532/endometrial-gene-expression-in-primiparous-dairy-cows-at-the-end-of-the-voluntary-waiting-period-is-affected-by-nutrition-total-mixed-ration-vs-increasing-levels-of-herbage-allowance
#14
A L Astessiano, M Carriquiry, D A Mattiauda, M L Adrien, P Chilibroste, A Meikle
The study postulated that differential nutritional management during the early lactation period would be reflected in endometrial expression of genes related to embryo growth at the end of the voluntary waiting period. Thus, the effect of the combined use of total mixed ration (TMR) and grazing under different herbage allowances during the first 75 days post-partum (DPP) on endometrial gene expression was evaluated in primiparous dairy cows. Cows were blocked by body weight, age and body condition score and randomly assigned to three grazing treatments: high (HA, 30 kg DM per cow per day), medium (MA, 15 kg DM per cow per day) and low (LA, 7...
April 12, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28387741/effects-of-low-molecular-weight-fucoidan-and-high-stability-fucoxanthin-on-glucose-homeostasis-lipid-metabolism-and-liver-function-in-a-mouse-model-of-type-ii-diabetes
#15
Hong-Ting Victor Lin, Yu-Chi Tsou, Yu-Ting Chen, Wen-Jung Lu, Pai-An Hwang
The combined effects of low-molecular-weight fucoidan (LMF) and fucoxanthin (Fx) in terms of antihyperglycemic, antihyperlipidemic, and hepatoprotective activities were investigated in a mouse model of type II diabetes. The intake of LMF, Fx, and LMF + Fx lowered the blood sugar and fasting blood sugar levels, and increased serum adiponectin levels. The significant decrease in urinary sugar was only observed in LMF + Fx supplementation. LMF and Fx had ameliorating effects on the hepatic tissue of db/db mice by increasing hepatic glycogen and antioxidative enzymes, and LMF was more effective than Fx at improving hepatic glucose metabolism...
April 7, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28378858/raspberry-ketone-fails-to-reduce-adiposity-beyond-decreasing-food-intake-in-c57bl-6-mice-fed-a-high-fat-diet
#16
Bradley M Cotten, Stephanie A Diamond, Taylor Banh, Yung-Hsuan Hsiao, Rachel M Cole, Jinhui Li, Christopher T Simons, Richard S Bruno, Martha A Belury, Yael Vodovotz
As the incidence of obesity continues to increase, identifying novel nutritional therapies to enhance weight loss are needed. Raspberry ketone (RK; 4-(4-hydroxyphenyl) butan-2-one) is a bioactive phytochemical that is marketed as a weight loss supplement in the United States, yet there is scant scientific evidence demonstrating that RK promotes weight loss. The aim of the current study was to investigate the effect of RK on accumulation of adipose mass, hepatic lipid storage, and levels of plasma adiponectin in mice fed a high-fat (HF) diet...
April 19, 2017: Food & Function
https://www.readbyqxmd.com/read/28373675/grape-seed-proanthocyanidin-supplementation-reduces-adipocyte-size-and-increases-adipocyte-number-in-obese-rats
#17
A Pascual-Serrano, A Arola-Arnal, S Suárez-Garcia, F I Bravo, M Suárez, L Arola, C Bladé
OBJECTIVES: White adipose tissue (WAT) expands through hypertrophy (increased adipocyte size) and/or hyperplasia (increased adipocyte number). Hypertrophy has been associated with insulin resistance and dyslipidemia independently of body composition and fat distribution. In contrast, hyperplasia protects against metabolic alterations. Proanthocyanidins, which are the most abundant flavonoids in the human diet, improve metabolic disturbances associated with diet-induced obesity without reducing body weight or adiposity...
April 4, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28333098/anti-obesity-and-anti-diabetic-effect-of-neoagarooligosaccharides-on-high-fat-diet-induced-obesity-in-mice
#18
Sun Joo Hong, Je-Hyeon Lee, Eun Joo Kim, Hea Jung Yang, Jae-Seon Park, Soon-Kwang Hong
Neoagarooligosaccharides (NAOs), mainly comprising neoagarotetraose and neoagarohexaose, were prepared by hydrolyzing agar with β-agarase DagA from Streptomyces coelicolor, and the anti-obesity and anti-diabetic effects of NAOs on high-fat diet (HFD)-induced obesity in mice were investigated after NAOs-supplementation for 64 days. Compared to the HFD group, the HFD-0.5 group that was fed with HFD + NAOs (0.5%, w/w) showed remarkable reduction of 36% for body weight gain and 37% for food efficiency ratios without abnormal clinical signs...
March 23, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28323947/effects-of-mixed-carotenoids-on-adipokines-and-abdominal-adiposity-in-children-a-pilot-study
#19
J Atilio Canas, Amanda Lochrie, Amy Galena McGowan, Jobayer Hossain, Christopher Schettino, P Babu Balagopal
Context: Carotenoids have been implicated in the regulation of adipocyte metabolism. Objective: To compare the effects of mixed-carotenoid supplementation (MCS) versus placebo on adipokines and the accrual of abdominal adiposity in children with obesity. Design and Setting: Randomized (1:1), double-blind, placebo-controlled intervention trial to evaluate the effects of MCS over 6 months in a subspecialty clinic. Participants: Twenty (6 male and 14 female) children with simple obesity [body mass index (BMI) > 90%], a mean age (± standard deviation) of 10...
June 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28282585/improvement-of-cardiometabolic-markers-after-fish-oil-intervention-in-young-mexican-adults-and-the-role-of-ppar%C3%AE-l162v-and-ppar%C3%AE-2-p12a
#20
Aristea Binia, Carolina Vargas-Martínez, Mónica Ancira-Moreno, Laura M Gosoniu, Ivan Montoliu, Elí Gámez-Valdez, Diana C Soria-Contreras, Adriana Angeles-Quezada, Rocío Gonzalez-Alberto, Silvia Fernández, Diego Martínez-Conde, Brianda Hernández-Morán, Marisol Ramírez-Solano, Carlos Pérez-Ortega, Yanelli Rodríguez-Carmona, Isabelle Castan, Isabel Rubio-Aliaga, Felipe Vadillo-Ortega, Ricardo Márquez-Velasco, Rafael Bojalil, Juan Carlos López-Alvarenga, Philippe Valet, Martin Kussmann, Irma Silva-Zolezzi, M Elizabeth Tejero
Polyunsaturated fatty acids (PUFA) contained in fish oil (FO) are ligands for peroxisome proliferator-activated receptors (PPAR) that may induce changes in cardiometabolic markers. Variation in PPAR genes may influence the beneficial responses linked to FO supplementation in young adults. The study aimed to analyze the effect of FO supplementation on glucose metabolism, circulating lipids and inflammation according to PPARα L162V and PPARγ2 P12A genotypes in young Mexican adults. 191 young, non-smoking subjects between 18 and 40 years were included in a one-arm study...
February 10, 2017: Journal of Nutritional Biochemistry
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