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https://www.readbyqxmd.com/read/29113747/differential-effects-of-epa-dpa-and-dha-on-cardio-metabolic-risk-factors-in-high-fat-diet-fed-mice
#1
Xiao-Fei Guo, Andrew J Sinclair, Gunveen Kaur, Duo Li
The aim of the present study was to assess and compare the effects of eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) supplementation on lipid metabolism in 4 month-old male C57BL/6J mice fed a high-fat diet. The high-fat fed mice showed evidence of fatty liver, obesity and insulin resistance after being on the high-fat diet for 6 weeks compared with the control low-fat diet fed mice. Supplementation of the high-fat diet with either EPA, DPA or DHA prevented the fatty liver, prevented high serum cholesterol and serum glucose and prevented high liver cholesterol levels...
September 22, 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29111889/the-combined-effects-of-exercise-diet-and-a-multi-ingredient-dietary-supplement-on-body-composition-and-adipokine-changes-in-overweight-adults
#2
Shawn M Arent, Alan J Walker, Joseph K Pellegrino, David J Sanders, Bridget A McFadden, Tim N Ziegenfuss, Hector L Lopez
BACKGROUND: Very few weight and fat loss supplements undergo finished-product research to examine efficacy. The purpose of this study was to determine the effects of an 8-week diet and exercise program on body composition, hip and waist girth, and adipokines and evaluate whether a dietary supplement containing raspberry ketone, capsaicin, caffeine, garlic, and Citrus aurantium enhanced outcomes. METHODS: Overweight men and women completed this randomized, placebo-controlled, double-blind study...
November 7, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29105398/oral-quercetin-supplementation-enhances-adiponectin-receptor-transcript-expression-in-polycystic-ovary-syndrome-patients-a-randomized-placebo-controlled-double-blind-clinical-trial
#3
Neda Rezvan, Ashraf Moini, Sattar Gorgani-Firuzjaee, Mohammad Javad Hosseinzadeh-Attar
OBJECTIVES: Polycystic ovary syndrome (PCOS), an ovarian-pituitary axis androgen disorder, is a common endocrine disease in women. Obesity-induced androgenesis and imbalance of adipokine secretion may lead to some metabolic features of PCOS. The beneficial effects of polyphenolic compounds such as quercetin have been reported, however, the underlying molecular mechanism is not entirely understood. In the present study, we investigated the effect of quercetin supplementation on the expression of adiponectin receptors at the transcript level in peripheral blood mononuclear cells (PBMC) samples of PCOS patients...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29101812/the-effect-of-ketorolac-and-triamcinolone-acetonide-on-adipogenic-and-hepatogenic-differentiation-through-mirnas-16-15-195-possible-clinical-application-in-regenerative-medicine
#4
Sedigheh Fekri Aval, Nosratollah Zarghami, Effat Alizadeh, Seyed Abolghasem Mohammadi
OBJECTIVE: The role of miR-16/15b/195 and complementary compounds in the commitment of mesenchymal stem cells (MSCs) to different lineages is unknown. The aim of this work was to investigate the effect of ketorolac and triamcinolone acetonide on adipogenic and hepatogenic processes, respectively. Also, miR-16/15 and miR-195 expression levels were evaluated under different induction conditions. METHODS: MSCs were isolated, expanded and directed using adipogenesis medium or medium supplemented with ketorolac, and also subjected to hepatogenic differentiation using a cocktail of hepatocyte growth factor (HGF) and Oncostatin M (OSM) either with or without triamcinolone acetonide...
November 1, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29098530/adiponectin-attenuates-streptozotocin-induced-tau-hyperphosphorylation-and-cognitive-deficits-by-rescuing-pi3k-akt-gsk-3%C3%AE-pathway
#5
Zhi-Peng Xu, Guo-Sheng Gan, Yu-Min Liu, Jin-Song Xiao, Han-Xing Liu, Bin Mei, Jun-Jian Zhang
Clinical studies have demonstrated that decreased adiponectin is associated with the development of Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). We focused on determining the neuroprotective effect offered by adiponectin against streptozotocin-induced brain damage in ICV-STZ rat model. We found that adiponectin supplements significantly restored the cognitive deficits in ICV-STZ rat model including shorter escape latency, more crossing times and increased time spent in the target quadrant. Adiponectin supplements also increased number of dendritic branches and mushroom percentage...
November 2, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29091879/protective-effect-of-the-hydroalcoholic-extract-of-tripodanthus-acutifolius-in-hypercholesterolemic-wistar-rats
#6
Ritiéle Pinto Coelho, Denise Lima Feksa, Patrícia Martinez Oliveira, Angélica Aparecida da Costa Güllich, Bruna Cocco Pilar, Jacqueline da Costa Escobar Piccoli, Vanusa Manfredini
Cardiovascular disease (CVD) are a major public health problem, as they are among the leading causes of mortality worldwide. Tripodanthus acutifolius (TA) is a hemiparasite plant used for medicinal purposes with great antioxidant capacity. However, little is known about its hypolipemic effect. Thus, the aim of this study was to evaluate the effects of the hydroalcoholic extract of Tripodanthus acutifolius leaves in hypercholesterolemic Wistar rats. The animals were divided into: (1) NC (Normocaloric Control); (2) HC (Hypercaloric Control); (3) Oral Simvastatin Suspension 10mg/kg (SIM); (4) TA extract 50mg/kg (TA 50mg/kg) and (5) TA 100mg/kg...
October 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29090980/dolichos-lablab-protects-against-nonalcoholic-fatty-liver-disease-in-mice-fed-high-fat-diets
#7
A-Rang Im, Yun Hee Kim, Young Hwa Kim, Won-Kyung Yang, Seung Hyung Kim, Kwang Hoon Song
Hyacinth bean, Dolichos lablab or Lablab purpureus, has been used for centuries in India and China as an edible pod and animal forage, as well as to treat diarrhea and other gastrointestinal disease in traditional Korean medicine. Recently, we have demonstrated that D. lablab extract (DLL-Ex) prevented free fatty acid-induced lipid accumulation in an in vitro cellular nonalcoholic fatty liver disease (NAFLD) model. In this study, we, thus, aimed at clarifying the hepatoprotective effects of DLL-Ex in a high-fat diet-induced in vivo animal NAFLD model, as well as at elucidating underlying mechanisms of identified effects...
November 1, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29067068/therapeutic-benefits-of-green-tea-extract-on-various-parameters-in-non-alcoholic-fatty-liver-disease-patients
#8
Mazhar Hussain, Habib-Ur-Rehman, Lubna Akhtar
BACKGROUND AND OBJECTIVE: NAFLD affecting up to 30% of the population globally. Drug treatment options are limited with disappointing results. The dietary supplementation in the form of green tea is another option. Our objective was toinvestigate the effect of Green tea extract (GTE) supplementation on various parameters innon-alcoholicfatty liver disease (NAFLD) patients. METHODS: This study was conducted Dept. of Medicineof Sheikh Zayed Medical College/Hospital, Rahim Yar Khan from 15 April 2016 to 15 July 2016...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29065507/fatty-acids-consumption-the-role-metabolic-aspects-involved-in-obesity-and-its-associated-disorders
#9
REVIEW
Priscila Silva Figueiredo, Aline Carla Inada, Gabriela Marcelino, Carla Maiara Lopes Cardozo, Karine de Cássia Freitas, Rita de Cássia Avellaneda Guimarães, Alinne Pereira de Castro, Valter Aragão do Nascimento, Priscila Aiko Hiane
Obesity and its associated disorders, such as insulin resistance, dyslipidemia, metabolic inflammation, dysbiosis, and non-alcoholic hepatic steatosis, are involved in several molecular and inflammatory mechanisms that alter the metabolism. Food habit changes, such as the quality of fatty acids in the diet, are proposed to treat and prevent these disorders. Some studies demonstrated that saturated fatty acids (SFA) are considered detrimental for treating these disorders. A high fat diet rich in palmitic acid, a SFA, is associated with lower insulin sensitivity and it may also increase atherosclerosis parameters...
October 22, 2017: Nutrients
https://www.readbyqxmd.com/read/29056106/the-influence-of-dietary-and-supplemental-calcium-on-postprandial-effects-of-a-high-fat-meal-on-lipaemia-glycaemia-c-reactive-protein-and-adiponectin-in-obese-women
#10
RANDOMIZED CONTROLLED TRIAL
Thaís da S Ferreira, Vanessa P Antunes, Priscila M Leal, Antonio F Sanjuliani, Márcia R S T Klein
Non-fasting hypertriacylglycerolaemia is a risk factor for CVD and the amount of fat in a meal seems to be the main factor influencing postprandial lipaemia. Although several studies suggest that Ca can increase faecal fat excretion, it is not known whether Ca can decrease postprandial TAG. This study aimed to evaluate the influence of dietary Ca (DC) and supplemental Ca (SC) on lipaemia, glucose metabolism, C-reactive protein (CRP) and adiponectin during postprandial period in obese women challenged with a high-fat meal...
October 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29032404/dietary-supplementation-with-methylseleninic-acid-inhibits-mammary-tumorigenesis-and-metastasis-in-male-mmtv-pymt-mice
#11
Sneha Sundaram, Lin Yan
Male breast cancer, which makes up approximately 1% of all breast cancers, is an aggressive disease with poor prognosis. We investigated the effects of dietary supplementation with selenium in the form of methylseleninic acid [(MSeA) 2.5 mg selenium/kg] on mammary tumorigenesis in male MMTV-PyMT mice. The mammary tumor latency was 14.6 weeks for the MSeA-fed group and 13.8 weeks for the controls fed the AIN93G diet (p < 0.05). Dietary supplementation with MSeA, versus the control, resulted in a 72% reduction in tumor progression, a 46% reduction in both final volume and weight of mammary tumors, and a 70% reduction in the number of lung metastases...
October 14, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29023845/aqueous-extract-of-gynura-bicolor-attenuated-hepatic-steatosis-glycative-oxidative-and-inflammatory-injury-induced-by-chronic-ethanol-consumption-in-mice
#12
Mei-Chin Yin, Zhi-Hong Wang, Wen-Hu Liu, Mei-Chin Mong
Gynura bicolor leaf aqueous extract (GAE) is rich in phytochemicals including phenolic acids, flavonoids, carotenoids, and anthocyanins. Effects of GAE upon hepatic injury in mice with chronic ethanol intake were examined. Lieber-DeCarli liquid diet with ethanol was used to induce hepatic lipid accumulation, oxidative, glycative, and inflammatory injury. GAE at 0.25% or 0.5% was added in feeds, and supplied to mice consumed Lieber-DeCarli liquid diet with ethanol for 6 wk. Blood and liver were collected for analyses...
October 12, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29019279/leucine-and-resistance-training-improve-hyperglycemia-white-adipose-tissue-loss-and-inflammatory-parameters-in-an-experimental-model-of-type-1-diabetes
#13
Henrique Quintas Teixeira Ribeiro, Audrey Yule Coqueiro, Vanessa Batista de Sousa Lima, Carlos Eduardo Carvalho Martins, Julio Tirapegui
BACKGROUND: Loss of white adipose tissue (WAT), associated with type 1 diabetes (DM1), contributes to increased chronic systemic inflammation. AIM: The aim of this study was to investigate the effects of leucine supplementation and resistance training (RT) in attenuating WAT loss and improving inflammatory parameters and glucose metabolism in DM1 rats. METHODS: Thirty-two male Wistar rats were distributed into four groups: DA (sedentary and supplemented with non-essential amino acids (NEAA)), DL (sedentary and supplemented with leucine), DTA (submitted to RT and supplemented with NEAA) and DTL (submitted to RT and supplemented with leucine)...
January 1, 2017: Nutrition and Health
https://www.readbyqxmd.com/read/29017158/beneficial-effects-of-n-3-fatty-acids-on-cardiometabolic-and-inflammatory-markers-in-type-2-diabetes-mellitus-a-randomized-placebo-controlled-double-blind-clinical-trial
#14
Maryam Mazaherioun, Mahmoud Djalali, Fariba Koohdani, Mohammad Hassan Javanbakht, Mahnaz Zarei, Maani Beigy, Samaneh Ansari, Neda Rezvan, Ahmad Saedisomeolia
OBJECTIVE: To determine the effect of n-3 polyunsaturated fatty acids (n-3PUFAs) supplementation on circulatory resistin and monocyte chemoattractant 1 (MCP-1) levels in type 2 diabetes mellitus (T2DM) patients. SUBJECTS AND METHODS: This was a ten-week, placebo-controlled, double-blind, randomized trial of n-3 PUFAs (2700 mg/day) vs. placebo (soft gels containing 900 mg of edible paraffin). Forty-four (44) T2DM patients were supplemented with n-3 PUFAs and another 44 patients received placebo (3 patients discontinued the trial)...
October 10, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28993384/can-coenzyme-q10-supplementation-effectively-reduce-human-tumour-necrosis-factor-%C3%AE-and-interleukin-6-levels-in-chronic-diseases-protocol-for-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#15
Farnaz Farsi, Javad Heshmati, Leila Janani, Pardis Irandoost, Naeimeh Mesri Alamdari, Abbasali Keshtkar, Abolfazl Akbari, Mohammadreza Vafa
INTRODUCTION: Inflammation, as a critical factor, can cause numerous chronic diseases by creating various proinflammatory cytokines. Coenzyme Q10 (CoQ10) can potentially exert an anti-inflammatory agent; in turn, this agent can reduce the systemic inflammatory response. The aims of this study are to conduct a comprehensive systematic review and a meta-analysis for the determination of the CoQ10 efficacy on the changes in serum interleukin-6 (IL-6) and the tumour necrosis factor-α (TNF-α) levels in unhealthy subjects...
October 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28986580/fenugreek-supplementation-during-high-fat-feeding-improves-specific-markers-of-metabolic-health
#16
Eric J Knott, Allison J Richard, Randall L Mynatt, David Ribnicky, Jacqueline M Stephens, Annadora Bruce-Keller
To assess the metabolically beneficial effects of fenugreek (Trigonella foenum-graecum), C57BL/6J mice were fed a low- or high-fat diet for 16 weeks with or without 2% (w/w) fenugreek supplementation. Body weight, body composition, energy expenditure, food intake, and insulin/glucose tolerance were measured regularly, and tissues were collected for histological and biochemical analysis after 16 weeks of diet exposure. Fenugreek did not alter body weight, fat mass, or food intake in either group, but did transiently improve glucose tolerance in high fat-fed mice...
October 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28983188/mango-supplementation-has-no-effects-on-inflammatory-mediators-in-obese-adults
#17
Shirley F Evans, Maureen Beebe, Maryam Mahmood, Sawanya Janthachotikun, Heba Eldoumi, Sandra Peterson, Mark Payton, Penelope Perkins-Veazie, Brenda J Smith, Edralin A Lucas
This pilot study examined the effects of freeze-dried mango (Mangifera indica L.) supplementation on anthropometric measurements, lipid parameters, and inflammatory mediators in obese individuals. A total of 20 obese (body mass index [BMI]: 30-35 kg/m(2)) adults (11 men and 9 women), aged 20 to 50 years, received 10 g/d of ground freeze-dried mango pulp for 12 weeks. Anthropometrics, lipids, and inflammatory mediators were assessed at baseline and after 12 weeks of mango supplementation. There were no differences between baseline and final visits in inflammatory mediators, lipids, diet, physical activity, and anthropometrics...
2017: Nutrition and Metabolic Insights
https://www.readbyqxmd.com/read/28974704/maternal-intake-of-grape-seed-procyanidins-during-lactation-induces-insulin-resistance-and-an-adiponectin-resistance-like-phenotype-in-rat-offspring
#18
Antoni Caimari, Roger Mariné-Casadó, Noemí Boqué, Anna Crescenti, Lluís Arola, Josep Maria Del Bas
Previously, we demonstrated that a grape seed procyanidin extract (GSPE) supplementation in pregnant and lactating rats exerted both healthy and deleterious programming effects on their offspring. Here, we evaluated whether the administration of GSPE during lactation (100 mg.kg(-1).day(-1)) in rats elicited beneficial effects in their normoweight (STD-GSPE group) and cafeteria-fed obese (CAF-GSPE group) adult male offspring. STD-GSPE and CAF-GSPE offspring showed increased energy expenditure and circulating total and high-molecular-weight adiponectin...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28952607/vitamin-k-induced-effects-on-body-fat-and-weight-results-from-a-3-year-vitamin-k2-intervention-study
#19
M H J Knapen, K M Jardon, C Vermeer
BACKGROUND/OBJECTIVES: Vitamin K status has been linked to fat and glucose metabolism by several authors, but whether high vitamin K intake influences body weight or composition has remained unclear. Here we tested the hypothesis that increased vitamin K intake decreases body fat or fat distribution. SUBJECTS/METHODS: In a randomized placebo-controlled human intervention trial, 214 postmenopausal women, 55-65 years of age, received either 180 mcg/day of vitamin K2 (menaquinone-7, MK-7) or placebo for 3 years...
September 27, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28942443/a-novel-role-of-sirt1-fgf-21-in-taurine-protection-against-cafeteria-diet-induced-steatohepatitis-in-rats
#20
Azza H Abd Elwahab, Basma K Ramadan, Mona F Schaalan, Amina M Tolba
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is one of the alarmingly rising clinical problems in the 21st century with no effective drug treatment until now. Taurine is an essential amino acid in humans that proved efficacy as a non-pharmacological therapy in a plethora of diseases; however, its impact on NAFLD remains elusive. The aim of the current study is to evaluate the protective mechanism of taurine in experimental steatohepatitis induced by junk food given as cafeteria-diet (CAF-D) in male albino rats...
2017: Cellular Physiology and Biochemistry
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