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Adiponectin AND AMPK

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https://www.readbyqxmd.com/read/29030114/impairment-of-energy-sensors-sirt1-and-ampk-in-lipid-induced-inflamed-adipocyte-is-regulated-by-fetuin-a
#1
Mrittika Chattopadhyay, Sandip Mukherjee, Subhendu K Chatterjee, Dipanjan Chattopadhyay, Snehasis Das, Subeer S Majumdar, Satinath Mukhopadhyay, Sutapa Mukherjee, Samir Bhattarcharya
Although several reports demonstrated that accumulation of excess lipid in adipose tissue produces defects in adipocyte which leads to the disruption of energy homeostasis causing severe metabolic problems, underlying mechanism of this event remains yet unclear. Here we demonstrate that FetuinA (FetA) plays a critical role in the impairment of two metabolic sensors, SIRT1 and AMPK, in inflamed adipocytes of high fat diet (HFD) mice. A linear increase in adipocyte hypertrophy from 10 to 16 week was in tandem with the increase in FetA and that coincided with SIRT1 cleavage and decrease in pAMPK which adversely affects PGC1α activation...
October 10, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/29018142/adiponectin-has-a-pivotal-role-in-the-cardioprotective-effect-of-cp-3-iv-a-selective-cd36-azapeptide-ligand-after-transient-coronary-artery-occlusion-in-mice
#2
David N Huynh, Valérie L Bessi, Liliane Ménard, Jérôme Piquereau, Caroline Proulx, Maria Febbraio, William D Lubell, André C Carpentier, Yan Burelle, Huy Ong, Sylvie Marleau
CD36 is a multiligand receptor involved in lipid metabolism. We investigated the mechanisms underlying the cardioprotective effect of CP-3(iv), an azapeptide belonging to a new class of selective CD36 ligands. The role of CP-3(iv) in mediating cardioprotection was investigated because CD36 signaling leads to activation of peroxisome proliferator-activated receptor-γ, a transcriptional regulator of adiponectin. CP-3(iv) pretreatment reduced infarct size by 54% and preserved hemodynamics in C57BL/6 mice subjected to 30 min coronary ligation and reperfusion but had no effect in CD36-deficient mice...
October 10, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28974704/maternal-intake-of-grape-seed-procyanidins-during-lactation-induces-insulin-resistance-and-an-adiponectin-resistance-like-phenotype-in-rat-offspring
#3
Antoni Caimari, Roger Mariné-Casadó, Noemí Boqué, Anna Crescenti, Lluís Arola, Josep Maria Del Bas
Previously, we demonstrated that a grape seed procyanidin extract (GSPE) supplementation in pregnant and lactating rats exerted both healthy and deleterious programming effects on their offspring. Here, we evaluated whether the administration of GSPE during lactation (100 mg.kg(-1).day(-1)) in rats elicited beneficial effects in their normoweight (STD-GSPE group) and cafeteria-fed obese (CAF-GSPE group) adult male offspring. STD-GSPE and CAF-GSPE offspring showed increased energy expenditure and circulating total and high-molecular-weight adiponectin...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28966224/interaction-between-bone-and-glucose-metabolism-review
#4
Ippei Kanazawa
Accumulating evidence has shown that bone and glucose metabolism are closely associated with each other. Since the risk of osteoporotic fractures is increased in patients with diabetes mellitus (DM), osteoporosis is recently recognized as one of diabetic complications, called DM-induced bone fragility. Previous studies showed that collagen cross-links of advanced glycation end products (AGEs) and dysfunctions of osteoblast and osteocyte are involved in DM-induced bone fragility. Circulating levels of AGEs and homocysteine are increased in patients with DM, and they directly impair the functions of osteoblast and osteocyte, resulting in decreased bone formation and bone remodeling...
September 30, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28957801/globular-adiponectin-attenuated-h2o2-induced-apoptosis-in-rat-chondrocytes-by-inducing-autophagy-through-the-ampk-mtor-pathway
#5
Junzheng Hu, Weiding Cui, Wenxiao Ding, Yanqing Gu, Zhen Wang, Weimin Fan
BACKGROUND/AIMS: Chondrocyte apoptosis is closely related to the development and progression of osteoarthritis. Global adiponectin (gAPN), secreted from adipose tissue, possesses potent anti-inflammatory and antiapoptotic properties in various cell types. This study aimed to investigate the role of autophagy induced by gAPN in the suppression of H2O2-induced apoptosis and the potential mechanism of gAPN-induced autophagy in chondrocytes. METHODS: H2O2 was used to induce apoptotic injury in rat chondrocytes...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28952262/-piperine-regulates-glucose-metabolism-disorder-in-hepg2-cells-of-insulin-resistance-models-via-targeting-upstream-target-of-ampk-signaling-pathway
#6
Chun-Ping Wan, Ya-Gai Wei, Xiao-Xue Li, Li-Jun Zhang, Rui Yang, Zhao-Ri-Ge-Tu Bao
To investigate the effect of piperine on the disorder of glucose metabolism in the cell model with insulin resistance (IR) and explore the molecules mechanism on intervening the upstream target of AMPK signaling pathway. The insulin resistance models in HepG2 cells were established by fat emulsion stimulation. Then glucose consumption in culture supernatant was detected by GOD-POD method. Enzyme-linked immunosorbent assay(ELISA) was used to measure the levels of leptin(LEP) and adiponectin(APN) in culture supernatant; Real-time quantitative PCR was used to assess the mRNA expression of APN and LEP; and the protein expression levels of LepR, AdipoR1, AdipoR2 and the activation of AMPK signaling pathway were detected by Western blot analysis...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28919424/adiponectin-modulates-the-function-of-endothelial-progenitor-cells-via-ampk-enos-signaling-pathway
#7
Shuhong Wang, Jie Miao, Meijie Qu, Guo-Yuan Yang, Linhui Shen
Endothelial progenitor cells have been shown to differentiate into endothelial cells and to play a pivotal role in vascular homeostasis. Adiponectin has anti-atherogenic and anti-inflammatory properties via directly acting on vascular cells. The aim of the present study is to explore the effect of adiponectin on major functions involved in survival, migration, and tube formation of endothelial progenitor cells and to explore the underlying mechanism. In this study, we transferred adiponectin gene into endothelial progenitor cells via lentiviral vectors and investigated the proliferation, migration and tube formation of these transfected cells...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28901521/adiponectin-receptor-agonist-adiporon-suppresses-adipogenesis-in-c3h10t1-2-cells-through-the-adenosine-monophosphate%C3%A2-activated-protein-kinase-signaling-pathway
#8
Shu-Juan Wang, Wen-Yi Lu, Kai-Yan Liu
The aim of the present study was to investigate the effects of AdipoRon, an adiponectin receptor agonist, on adipogenesis in C3H10T1/2 cells and to explore the underlying mechanisms. C3H10T1/2 cells were treated with increasing doses of AdipoRon for 8 days, and Oil Red O staining was used to assess lipid accumulation. The protein and mRNA expression levels of adipogenic transcription factors and adipocyte‑specific genes were examined by western blotting and reverse transcription quantitative polymerase chain reaction, respectively...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28840618/the-beneficial-effect-of-anthocyanidin-rich-vitis-vinifera-l-grape-skin-extract-on-metabolic-changes-induced-by-high-fat-diet-in-mice-involves-antiinflammatory-and-antioxidant-actions
#9
Gisele França da Costa, Izabelle Barcellos Santos, Graziele Freitas de Bem, Viviane Silva Cristino Cordeiro, Cristiane Aguiar da Costa, Lenize Costa Reis Marins de Carvalho, Dayane Teixeira Ognibene, Angela Castro Resende, Roberto Soares de Moura
We hypothesized that a polyphenol-rich extract from Vitis vinifera L. grape skin (GSE) may exert beneficial effects on obesity and related metabolic disorders induced by a high-fat diet (HFD). C57/BL6 mice were fed a standard diet (10% fat, control, and GSE groups) or an HFD (60% fat, high fat (HF), and HF + GSE) with or without GSE (200 mg/kg/day) for 12 weeks. GSE prevented weight gain; dyslipidemia; insulin resistance; the alterations in plasma levels of leptin, adiponectin, and resistin; and the deregulation of leptin and adiponectin expression in adipose tissue...
August 25, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28825851/restoring-diabetes-induced-autophagic-flux-arrest-in-ischemic-reperfused-heart-by-adipor-adiponectin-receptor-activation-involves-both-ampk-dependent-and-ampk-independent-signaling
#10
Yajing Wang, Bin Liang, Wayne Bond Lau, Yunhui Du, Rui Guo, Zheyi Yan, Lu Gan, Wenjun Yan, Jianli Zhao, Erhe Gao, Walter Koch, Xin-Liang Ma
Macroautophagy/autophagy is increasingly recognized as an important regulator of myocardial ischemia-reperfusion (MI-R) injury. However, whether and how diabetes may alter autophagy in response to MI-R remains unknown. Deficiency of ADIPOQ, a cardioprotective molecule, markedly increases MI-R injury. However, the role of diabetic hypoadiponectinemia in cardiac autophagy alteration after MI-R is unclear. Utilizing normal control (NC), high-fat-diet-induced diabetes, and Adipoq knockout (adipoq(-/-)) mice, we demonstrated that autophagosome formation was modestly inhibited and autophagosome clearance was markedly impaired in the diabetic heart subjected to MI-R...
August 21, 2017: Autophagy
https://www.readbyqxmd.com/read/28811634/molecular-cloning-and-expression-of-osmotin-in-a-baculovirus-insect-system-purified-osmotin-mitigates-amyloid-beta-deposition-in-neuronal-cells
#11
Noman Bin Abid, Gwangho Yoon, Myeong Ok Kim
Osmotin is a pathogenesis-related plant protein, have gained focus of research because of its homology with mammalian adiponectin. The therapeutic properties of osmotin have been explored in recent years as it exhibits neuroprotective effects against amyloid beta-, glutamate- and ethanol-induced synaptic dysfunction and neurodegeneration. In the present study, the full-length gene of the tobacco plant osmotin was cloned and expressed in the Sf9 insect cell line using the baculovirus expression system. In vitro analysis of purified Osmotin protein showed excellent cell viability, p-AMPK activation and a reduction in amyloid-beta deposition...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28805698/artemisia-iwayomogi-extract-attenuates-high-fat-diet-induced-hypertriglyceridemia-in-mice-potential-involvement-of-the-adiponectin-ampk-pathway-and-very-low-density-lipoprotein-assembly-in-the-liver
#12
Jinhui Lee, Vikram P Narayan, Eun Young Hong, Wan Kyunn Whang, Taesun Park
This study aimed to examine the protective effect of Artemisia iwayomogi extract (AI) against hypertriglyceridemia induced by a high-fat diet (HFD) in mice and to uncover the underlying molecular mechanisms. C57BL/6N mice were fed chow, HFD, HFD + 0.1% AI, HFD + 0.25% AI, or HFD + 0.5% AI for 10 weeks. The addition of 0.25% and 0.5% AI resulted in dose-dependent improvements in the major parameters of hypertriglyceridemia, including plasma triglyceride, free fatty acids, apolipoprotein B, and lipoprotein lipase, with parallel reductions in body weight gain, hepatic lipid accumulation, and insulin resistance...
August 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28750043/correction-adiponectin-attenuates-high-glucose-induced-apoptosis-through-the-ampk-p38-mapk-signaling-pathway-in-nrk-52e-cells
#13
Yuanyuan Wang, Juan Zhang, Lian Zhang, Ping Gao, Xiaoyan Wu
[This corrects the article DOI: 10.1371/journal.pone.0178215.].
2017: PloS One
https://www.readbyqxmd.com/read/28696138/adipoq-adiponectin-induces-cytotoxic-autophagy-in-breast-cancer-cells-through-stk11-lkb1-mediated-activation-of-the-ampk-ulk1-axis
#14
Seung J Chung, Ganji Purnachandra Nagaraju, Arumugam Nagalingam, Nethaji Muniraj, Panjamurthy Kuppusamy, Alyssa Walker, Juhyung Woo, Balázs Győrffy, Ed Gabrielson, Neeraj K Saxena, Dipali Sharma
ADIPOQ/adiponectin, an adipocytokine secreted by adipocytes in the breast tumor microenvironment, negatively regulates cancer cell growth hence increased levels of ADIPOQ/adiponectin are associated with decreased breast cancer growth. However, its mechanisms of action remain largely elusive. We report that ADIPOQ/adiponectin induces a robust accumulation of autophagosomes, increases MAP1LC3B-II/LC3B-II and decreases SQSTM1/p62 in breast cancer cells. ADIPOQ/adiponectin-treated cells and xenografts exhibit increased expression of autophagy-related proteins...
August 3, 2017: Autophagy
https://www.readbyqxmd.com/read/28686516/standardized-cirsium-setidens-nakai-ethanolic-extract-suppresses-adipogenesis-and-regulates-lipid-metabolisms-in-3t3-l1-adipocytes-and-c57bl-6j-mice-fed-high-fat-diets
#15
Bong-Yeon Cho, Mi-Ryeong Park, Jin-Ha Lee, Moon-Jin Ra, Kyoung Chan Han, Il-Jun Kang, Ok-Hwan Lee
Cirsium setidens Nakai, a wild perennial herb, grows mainly in Gangwon province, Korea, and has been reported to contain bioactive ingredients with various medicinal activities, including the treatment of edema, bleeding, and hemoptysis. However, the potential antiobesity effects of C. setidens Nakai have not been fully investigated. This study evaluated the antiobesity effect of standardized C. setidens Nakai ethanolic extract (CNE) in 3T3-L1 adipocytes and in obese C57BL/6J mice fed a high-fat diet. CNE suppressed the expression of lipogenic genes and increased the expression of lipolytic genes...
August 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28676553/voluntary-physical-activity-counteracts-the-proliferative-tumor-growth-microenvironment-created-by-adipose-tissue-via-high-fat-diet-feeding-in-female-rats
#16
Christopher F Theriau, Michael K Connor
The adipokine secretion profile created from adipose tissue may represent the molecular mechanism behind the obesity-breast cancer association. Two adipokines, adiponectin (ADIPO), and leptin (LEP), are altered with obesity and exert antagonistic effects on breast cancer proliferation. We set out to determine whether the adipose-dependent tumor promoting growth environment created by a high-fat diet (HFD) in female Sprague-Dawley rats is altered compared to established responses in male rats and whether voluntary physical activity (PA) ameliorates any HFD-dependent effects...
July 2017: Physiological Reports
https://www.readbyqxmd.com/read/28624657/adiponectin-improves-the-osteointegration-of-titanium-implant-under-diabetic-conditions-by-reversing-mitochondrial-dysfunction-via-the-ampk-pathway-in-vivo-and-in-vitro
#17
Xiao-Fan Hu, Lin Wang, Yi-Zhao Lu, Geng Xiang, Zi-Xiang Wu, Ya-Bo Yan, Yang Zhang, Xiong Zhao, Yuan Zang, Lei Shi, Wei Lei, Ya-Fei Feng
Diabetes-induced reactive oxygen species (ROS) overproduction would result in compromised osteointegration of titanium implant (TI) and high rate of implant failure, yet the underlying mechanisms remain elusive. Adiponectin (APN) is a fat-derived adipocytokine with strong antioxidant, mitochondrial-protective and anti-diabetic efficacies. We hypothesized that mitochondrial dysfunction under diabetes may account for the oxidative stress in osteoblasts and titanium-bone interface (TBI) instability, which could be ameliorated by APN...
June 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28617316/globular-adiponectin-inhibits-lipopolysaccharide-primed-inflammasomes-activation-in-macrophages-via-autophagy-induction-the-critical-role-of-ampk-signaling
#18
Mi Jin Kim, Eun Hye Kim, Nirmala TiliJa Pun, Jae-Hoon Chang, Jung-Ae Kim, Jee-Heon Jeong, Dong Young Choi, Sang-Hyun Kim, Pil-Hoon Park
The inflammasome acts as a key platform for the activation of pro-inflammatory cytokines. Adiponectin exhibits potent anti-inflammatory properties. However, the effect of adiponectin on the modulation of the inflammasome has not been explored. Herein, we show that globular adiponectin (gAcrp) suppressed lipopolysaccharide (LPS)-primed inflammasomes activation in murine peritoneal macrophages judged by prevention of interleukin-1β (IL-1β) maturation, caspase-1 activation, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) speck formation, and pyroptotic cell death...
June 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28608766/wsf-p-1-a-novel-ampk-activator-promotes-adiponectin-multimerization-in-3t3-l1-adipocytes
#19
Yao Wang, Yudian Zhang, Yunyun Wang, Han Peng, Jian Rui, Zhijie Zhang, Shifa Wang, Zhen Li
Adiponectin, an adipokine with insulin-sensitizing effect, is secreted from adipocytes into circulation as high, medium, and low molecular weight forms (HMW, MMW, and LMW). The HMW adiponectin oligomers possess the most potent insulin-sensitizing activity. WSF-P-1(N-methyl-1,2,3,4,5,6-hexahydro-1,1,5,5-tetramethyl-7H-2,4α-methanonaphthalen-7-amine) is derived from natural sesquiterpene longifolene by chemical modifications. We found that WSF-P-1 activates AMPK in both 3T3-L1 adipocytes and 293T cells in this study...
August 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28587677/anti-obesity-activity-acute-toxicity-and-chemical-constituents-of-aqueous-and-ethanol-viola-mandshurica-extracts
#20
Yoon-Young Sung, Dong-Seon Kim, Seung-Hyung Kim, Ho Kyoung Kim
BACKGROUND: Viola mandshurica has traditionally been used as an expectorant, diuretic, and anti-inflammatory drug. The present study was designed to test the hypothesis that low doses of two different V. mandshurica extracts have anti-obesity effects. METHODS: We evaluated the effects of ethanol extract (VME) and aqueous extract (VMA) from V. mandshurica on high-fat diet (HFD)-induced obese mice as well as the acute oral toxicities and chemical compositions of both extracts...
June 6, 2017: BMC Complementary and Alternative Medicine
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