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https://www.readbyqxmd.com/read/27886664/degradation-behaviors-of-geometric-cues-and-mechanical-properties-in-a-3d-scaffold-for-tendon-repair
#1
Yang Wu, Yoke San Wong, Jerry Ying Hsi Fuh
A three-dimensional (3D) scaffold fabricated via electrohydrodynamic jet printing (E-jetting) and thermally uniaxial stretching, has been developed for tendon tissue regeneration in our previous study. In this study, more in-depth biological test showed that the aligned cell morphology guided by the anisotropic geometries of the 3D tendon scaffolds, leading to up-regulated tendious gene expression including collagen type I, decorin, tenascin-C and biglycan, as compared to the electrospun scaffolds. Given the importance of geometric cues to the biological function of the scaffolds, the degradation behaviors of the 3D scaffolds were investigated...
November 25, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27860287/proteoglycan-neofunctions-regulation-of-inflammation-and-autophagy-in-cancer-biology
#2
Liliana Schaefer, Claudia Tredup, Maria A Gubbiotti, Renato V Iozzo
Inflammation and autophagy have emerged as prominent issues in the context of proteoglycan signaling. In particular, two small, leucine-rich proteoglycans, biglycan and decorin, play pivotal roles in the regulation of these vital cellular pathways and, as such, are intrinsically involved in cancer initiation and progression. In this minireview we will address novel functions of biglycan and decorin in inflammation and autophagy, and analyze new emerging signaling events triggered by these proteoglycans, which directly or indirectly modulate these processes...
November 17, 2016: FEBS Journal
https://www.readbyqxmd.com/read/27830278/molecular-communication-from-skeletal-muscle-to-bone-a-review-for-muscle-derived-myokines-regulating-bone-metabolism
#3
REVIEW
Baosheng Guo, Zong-Kang Zhang, Chao Liang, Jie Li, Jin Liu, Aiping Lu, Bao-Ting Zhang, Ge Zhang
Besides the mechanical loading-dependent paradigm, skeletal muscle also serves as an endocrine organ capable of secreting cytokines to modulate bone metabolism. In this review, we focused on reviewing the myokines involved in communication from skeletal muscle to bone, i.e. (1) myostatin and myostatin-binding proteins including follistatin and decorin, (2) interleukins including interleukin-6 (IL-6), interleukin-7 (IL-7) and interleukin-15 (IL-15), (3) insulin-like growth factor 1 (IGF-1) and its binding proteins, (4) other myokines including PGC-1α-irisin system and osteoglycin (OGN)...
November 9, 2016: Calcified Tissue International
https://www.readbyqxmd.com/read/27828834/serum-decorin-interleukin-1%C3%AE-and-transforming-growth-factor-%C3%AE-predict-hypertrophic-scarring-postburn
#4
Peter O Kwan, Jie Ding, Edward E Tredget
Hypertrophic scar after burn injury is a significant problem. Previous studies have examined the roles for decorin, interleukin-1β, and transforming growth factor-β1 in hypertrophic scar formation locally, but few have considered their systemic influence. The authors conducted a pilot study to examine whether serum levels of these molecules could predict hypertrophic scar formation. Serum levels were measured using enzyme-linked immunosorbent assay, and hypertrophic scar formation determined from chart reviews...
November 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27791138/laminin-targeting-of-a-peripheral-nerve-highlighting-peptide-enables-degenerated-nerve-visualization
#5
Heather L Glasgow, Michael A Whitney, Larry A Gross, Beth Friedman, Stephen R Adams, Jessica L Crisp, Timon Hussain, Andreas P Frei, Karel Novy, Bernd Wollscheid, Quyen T Nguyen, Roger Y Tsien
Target-blind activity-based screening of molecular libraries is often used to develop first-generation compounds, but subsequent target identification is rate-limiting to developing improved agents with higher specific affinity and lower off-target binding. A fluorescently labeled nerve-binding peptide, NP41, selected by phage display, highlights peripheral nerves in vivo. Nerve highlighting has the potential to improve surgical outcomes by facilitating intraoperative nerve identification, reducing accidental nerve transection, and facilitating repair of damaged nerves...
October 20, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27786166/impact-of-osmoregulatory-agents-on-the-recovery-of-collagen-conformation-in-decellularized-corneas
#6
Sumit Murab, Sourabh Ghosh
The process of decellularization of the cornea leads to the removal of cells and antigens. However, during decellularization the ultrastructure of the corneal matrix is usually damaged and a secondary conformation of the collagen fibrils is modulated resulting in altered transparency and physical properties. The strategy for recovering modulation in collagen conformation may help to attain the native physical properties and transparency of the cornea. Decellularized corneas were treated with varied concentrations of glycerol and dextran, and the collagen conformation was monitored by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), x-ray diffraction (XRD) and Raman spectroscopic analysis...
October 27, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27765088/-effects-of-local-transplantation-of-autologous-adipose-derived-mesenchymal-stem-cells-on-the-formation-of-hyperplastic-scar-on-rabbit-ears
#7
L Chen, D L Wang, Z R Wei, B Wang, J P Qi, G F Sun
Objective: To investigate the effects of local transplantation of autologous adipose-derived mesenchymal stem cells (ADSCs) on the formation of hyperplastic scar on rabbit ears. Methods: ADSCs were isolated from inguinal fat of six New Zealand rabbits and then sub-cultured. ADSCs of the third passage of each rabbit were used in the following experiments. Six full-thickness skin defect wounds with diameter of 6 mm on the ventral surface of every rabbit ear were made. Wound healing and local-tissue proliferation were observed, and complete epithelization time of wounds and formation time of hyperplastic scar were recorded...
October 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27744073/does-decorin-protect-neuronal-tissue-via-its-antioxidant-and-antiinflammatory-activity-from-traumatic-brain-injury-an-experimental-study
#8
Rafet Özay, Erhan Türkoğlu, Bora Gürer, Habibullah Dolgun, Oya Evirgen, Berrin İmge Ergüder, Nazlı Hayırlı, Levent Gürses, Zeki Şekerci, Erdal Reşit Yılmaz
BACKGROUND: The development of secondary brain injury via oxidative stress after traumatic brain injury (TBI) is well known. Decorin inactivates Transforming growth factor-β1 (TGF-β1), complement system (CS) and Tumor necrosis factor-α (TNF-α) which are related the oxidative stress and apoptosis. Consequently, the aim of the present study was to evaluate the role of Decorin (DC) on TBI. METHODS: A total of 24 male rats were used and divided into four groups as follows; control, trauma, DC, and methylprednisolone (MP)...
October 12, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27733818/expression-patterns-of-extracellular-matrix-proteins-during-posterior-commissure-development
#9
Karen Stanic, Natalia Saldivia, Benjamín Förstera, Marcela Torrejón, Hernán Montecinos, Teresa Caprile
Extracellular matrix (ECM) molecules are pivotal for central nervous system (CNS) development, facilitating cell migration, axonal growth, myelination, dendritic spine formation, and synaptic plasticity, among other processes. During axon guidance, the ECM not only acts as a permissive or non-permissive substrate for navigating axons, but also modulates the effects of classical guidance cues, such as netrin or Eph/ephrin family members. Despite being highly important, little is known about the expression of ECM molecules during CNS development...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27726099/reduced-decorin-expression-in-the-tumor-stroma-correlates-with-tumor-proliferation-and-predicts-poor-prognosis-in-patients-with-i-iiia-non-small-cell-lung-cancer
#10
Xuan Hong, Zhaoyang Yang, Meng Wang, Li Wang, Qingyong Xu
Decorin, chiefly synthesized by tumor stroma, is known as a tumor suppressor. However, the clinical and prognostic significance in lung cancer remained unclear. Here, decorin and Ki67 expression was detected by immunohistochemistry (IHC) in I-IIIA non-small cell lung cancer (NSCLC) tissues (n = 264) in comparison to adjacent normal tissues (n = 40). The relationship between the expression of decorin and clinical characteristics, as well as Ki67 index and prognosis, was analyzed. Decorin expression was decreased in both the stroma (P < 0...
October 10, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27699222/maternal-obesity-drives-functional-alterations-in-uterine-nk-cells
#11
Sofie Perdu, Barbara Castellana, Yoona Kim, Kathy Chan, Lauren DeLuca, Alexander G Beristain
Over one-fifth of North American women of childbearing age are obese, putting these women at risk for a variety of detrimental chronic diseases. In addition, obesity increases the risk for developing major complications during pregnancy. The mechanisms by which obesity contributes to pregnancy complications and loss remain unknown. Increasing evidence indicates that obesity results in major changes to adipose tissue immune cell composition and function; whether or not obesity also affects immune function in the uterus has not been explored...
July 21, 2016: JCI Insight
https://www.readbyqxmd.com/read/27698710/decorin-inhibits-the-proliferation-of-hepg2-cells-by-elevating-the-expression-of-transforming-growth-factor-%C3%AE-receptor-ii
#12
Yanfeng Liu, Xuesong Wang, Zhaohui Wang, Wenbo Ju, Dawei Wang
The aim of the present study was to investigate the effects of decorin (DCN) on the proliferation of human hepatoma HepG2 cells and the involvement of transforming growth factor-β (TGF-β) signaling pathway. A vector containing DCN was transfected into HepG2 cells with the use of Lipofectamine 2000. Cell proliferation was assessed with an MTT assay, and western blot analysis was used to detect the protein expression of TGF-β receptor I (TGF-βRI), phosphorylated TGF-βRI, p15 and TGF-βRII. In addition, small interfering RNA (siRNA) silencing was performed to knock down the target gene...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27698699/decorin-reduces-hypertrophic-scarring-through-inhibition-of-the-tgf-%C3%AE-1-smad-signaling-pathway-in-a-rat-osteomyelitis-model
#13
Peng Wang, Xiangyan Liu, Peng Xu, Jialiang Lu, Runze Wang, Weidong Mu
Chronic osteomyelitis is a bone infection that results in hypertrophic scarring of the soft tissue surrounding the infected bone. This scarring can create functional problems and its treatment is challenging. The aim of the present study was to evaluate the efficacy of decorin in treating scar formation in osteomyelitis and the underlying mechanism of its action. A rat osteomyelitis model was used, and animals were divided into three groups, as follows: Group A (control), group B (osteomyelitis model) and group C (decorin-treated)...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27693454/decorin-interacting-network-a-comprehensive-analysis-of-decorin-binding-partners-and-their-versatile-functions
#14
Maria A Gubbiotti, Sylvain D Vallet, Sylvie Ricard-Blum, Renato V Iozzo
Decorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and autophagy. This functional versatility arises from a wide array of decorin/protein interactions also including interactions with its single glycosaminoglycan side chain. The decorin-binding partners encompass numerous categories ranging from extracellular matrix molecules to cell surface receptors to growth factors and enzymes. Despite the diversity of the decorin interacting network, two main roles emerge as prominent themes in decorin function: maintenance of cellular structure and outside-in signaling, culminating in anti-tumorigenic effects...
September 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27644884/the-extracellular-matrix-regulates-the-effect-of-decorin-and-transforming-growth-factor-beta-2-tgf-%C3%AE-2-on-myoblast-migration
#15
K P Goetsch, C U Niesler
Muscular injuries that destroy the basal lamina result in poor functional recovery of skeletal muscle. This is due, in part, to the deposition of structural fibrotic proteins such as fibronectin and collagen by fibroblasts and other cells. Transforming growth factor-β (TGF-β) promotes fibrosis, whereas the proteoglycan decorin is known to act as an anti-fibrotic agent, in part via the binding and neutralization of TGF-β. We have previously established that decorin can alter the migratory response of skeletal muscle myoblasts to the extracellular matrix (ECM) factor collagen, but not fibronectin...
October 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27640956/usp2-69-overexpression-slows-down-the-progression-of-rat-anti-thy1-1-nephritis
#16
Xing Mao, Weili Luo, Jianyong Sun, Nianji Yang, Linda Wei Zhang, Zhonghua Zhao, Zhigang Zhang, Huijuan Wu
Mesangial proliferative glomerulonephritis is characterized by proliferation of mesangial cells (MCs) and transforming growth factor-β (TGF-β)-dependent stimulation of abnormal extracellular matrix (ECM) accumulation. We previously showed that Decorin--a leucine-rich proteoglycan inhibiting the progression of glomerulonephritis and glomerular sclerosis--can be degraded by the ubiquitin-proteasome pathway and deubiquitinated and stabilized by ubiquitin-specific processing protease 2-69(Usp2-69). Usp2-69 is highly expressed in the kidney and has been implicated in the regulation of cell proliferation and apoptosis...
September 15, 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27630718/induction-of-tenogenic-differentiation-mediated-by-extracellular-tendon-matrix-and-short-term-cyclic-stretching
#17
Janina Burk, Amelie Plenge, Walter Brehm, Sandra Heller, Bastian Pfeiffer, Cornelia Kasper
Tendon and ligament pathologies are still a therapeutic challenge, due to the difficulty in restoring the complex extracellular matrix architecture and biomechanical strength. While progress is being made in cell-based therapies and tissue engineering approaches, comprehensive understanding of the fate of progenitor cells in tendon healing is still lacking. The aim of this study was to investigate the effect of decellularized tendon matrix and moderate cyclic stretching as natural stimuli which could potentially direct tenogenic fate...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27627554/identification-of-small-peptides-of-acidic-collagen-extracts-from-silver-carp-skin-and-their-therapeutic-relevance
#18
Diana Wojtkowiak, Andrzej F Frydrychowski, Jakub Hadzik, Marzena Dominiak
BACKGROUND: Low-temperature techniques that prevent protein denaturation are being used to extract collagen from fish skin for cosmetic purposes. These extracts contain collagen with its triple helix structure preserved, as well as a number of other proteins. OBJECTIVES: The aim of the study was to investigate collagen extracts from the skin of silver carp for the presence of small-molecule peptides. MATERIAL AND METHODS: Liquid chromatography-mass spectrometry (HPLC-MS) was performed to analyze collagen extracts from silver carp skin for the presence of small-molecule peptides...
March 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27624935/ring-mesh-model-of-proteoglycan-glycosaminoglycan-chains-in-tendon-based-on-three-dimensional-reconstruction-by-focused-ion-beam-scanning-electron-microscopy
#19
Takafumi Watanabe, Kiyokazu Kametani, Yoh-Ichi Koyama, Daisuke Suzuki, Yasutada Imamura, Kazushige Takehana, Kohzy Hiramatsu
Tendons are composed of collagen fibrils and proteoglycan predominantly consisting of decorin. Decorin is located on the d-band of collagen fibrils, and its glycosaminoglycan (GAG) chains have been observed between collagen fibrils with transmission electron microscopy. GAG chains have been proposed to interact with each other or with collagen fibrils, but its three-dimensional organization remains unclear. In this report, we used focused ion beam scanning electron microscopy to examine the three-dimensional organization of the GAG chain in the Achilles tendon of mature rats embedded in epoxy resin after staining with Cupromeronic blue, which specifically stains GAG chains...
November 4, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27614617/biological-function-of-unique-sulfated-glycosaminoglycans-in-primitive-chordates
#20
Konstantina Karamanou, Diana Carolina Restrepo Espinosa, Anneliese Fortuna-Costa, Mauro Sérgio Gonçalves Pavão
Glycosaminoglycans with unique sulfation patterns have been identified in different species of ascidians (sea squirts), a group of marine invertebrates of the Phylum Chordata, sub-phylum Tunicata (or Urochordata). Oversulfated dermatan sulfate composed of [4-α-L-IdoA-(2-O-SO3)(-1) → 3-β-D-GalNAc(4-OSO3)(-1)]n repeating disaccharide units is found in the extracellular matrix of several organs, where it seems to interact with collagen fibers. This dermatan sulfate co-localizes with a decorin-like protein, as indicated by immunohistochemical analysis...
September 10, 2016: Glycoconjugate Journal
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