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Odontogenic keratocyst

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https://www.readbyqxmd.com/read/29930360/surgical-treatments-for-nonsyndromic-odontogenic-keratocysts
#1
Silvia Spivakovsky
Data sourcesPubMed/MEDLINE, Science Direct, Web of Science, Scopus and the Cochrane Library were searched until October 2017.Study selectionClinical trials, controlled trials, retrospective studies and case series containing at least ten cases with a minimum follow-up of ten years of patients treated with marsupialisation or decompression with or without enucleation, and enucleation alone evaluating the recurrence rates.Data extraction and synthesisTwo reviewers independently assessed for eligibility and extracted data...
June 2018: Evidence-based Dentistry
https://www.readbyqxmd.com/read/29926463/fascin-expression-in-ameloblastoma-odontogenic-keratocyst-and-dentigerous-cyst
#2
Sedigheh Rahrotaban, Nariman Nikparto, Parham Yousefizadeh, Mohammad Javad Kharazifard, Samira Derakhshan
OBJECTIVE: The purpose of this study was to assess and compare fascin expression in 4 lesions which differ in aggressiveness: odontogenic keratocyst, dentigerous cyst and two types of ameloblastoma (solid and unicystic), and to find out whether fascin expression is associated with aggressiveness of these lesions or not. MATERIAL AND METHOD: Nine solid ameloblastomas , 12 unicystic ameloblastomas, 13 odontogenic keratocyst and 12 dentigerous cyst were assessed in this study...
June 21, 2018: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/29924761/recurrence-rate-of-odontogenic-keratocyst-treated-by-enucleation-and-peripheral-ostectomy-retrospective-case-series-with-up-to-12-years-of-follow-up
#3
Ç Karaca, K-A Dere, N Er, A Aktaş, E Tosun, O-T Köseoğlu, A Usubütün
BACKGROUND: Odontogenic keratocysts have been reported with high recurrence rates in the literature so various treatment modalities from simple enucleation to resection have been performed to achieve the cure. The purpose of this retrospective study was to investigate the recurrence rate of odontogenic keratocysts (OKCs) treated by enucleation and peripheral ostectomy. MATERIAL AND METHODS: An electronic search of the database of the Hacettepe University, Faculty of Medicine, Department of Pathology, was undertaken to identify patients histologically diagnosed with OKCs treated at Department of Oral and Maxillofacial Surgery between 2001 and 2015...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29892529/quantitative-analysis-of-argyrophilic-nucleolar-organizer-regions-in-odontogenic-cysts-and-tumor-a-comparative-study
#4
Bhavana Gupta, Shaleen Chandra, Vineet Raj, Vivek Gupta
Background: The nucleolar organizer region (NOR) is by definition part of a chromosome, and nucleolus is a structure containing this chromosomal part and in addition the material which accumulate around the NOR, mostly rRNAs and their precursors as well as specific ribosomal proteins. Argyrophilic Nucleolar organizing region (AgNOR) are silver binding NORs often used to study cell proliferation in various types of tumors. Aim: Quantitative assessment of Argyrophilic Nucleolar organizing region count and its comparison among dentigerous cyst, keratocystic odontogenic tumor and ameloblastoma...
May 2018: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/29892328/a-case-of-an-extensive-keratocystic-odontogenic-tumor-in-the-mandible-reconstructed-with-a-custom-made-total-joint-prosthesis
#5
Payam Farzad
The use of virtual surgical planning and computer-aided design/computer-aided manufacturing has previously been reported to enhance the planning for the reconstruction of mandibular continuity defects and to reduce surgical time. Reported is a case of a large keratocystic odontogenic tumor (KOT) affecting right hemimandible including the condylar neck. This case was initially reconstructed with a condyle-bearing reconstruction plate, but because of fatigue fracture 15 years later, a new reconstruction with a custom-made total joint temporomandibular prosthesis was performed...
June 2018: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/29850338/initial-stage-primary-intraosseous-squamous-cell-carcinoma-derived-from-odontogenic-keratocyst-with-unusual-keratoameloblastomatous-change-of-the-maxilla-a-case-report-and-literature-discussion
#6
Kentaro Kikuchi, Fumio Ide, Shota Takizawa, Seiji Suzuki, Hideaki Sakashita, Tie-Jun Li, Kaoru Kusama
Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant neoplasm derived from odontogenic epithelial remnants in the central jaw bone. Most PIOSCCs originate from odontogenic cysts with a nonkeratinized epithelial lining, especially from radicular/residual and dentigerous cysts. There have been few reports of PIOSCCs derived from the odontogenic keratocyst (OKC), particularly those describing pathological features at the initial stage. The diagnosis of PIOSCC is difficult and based on exclusion of other carcinomas, including metastatic tumors from other primary sites...
2018: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29802703/amelogenin-is-a-potential-biomarker-for-the-aggressiveness-in-odontogenic-tumors
#7
Safa Zakaraia, Mamdouh Almohareb, Khaled Zaid, Mazen Doumani, Mohammad Yaman Seirawan
Amelogenin (AMEL), the major structural protein of the enamel organic matrix, constitutes more than 90% of the enamel’s protein content, Aberrations of amelogenin are thought to be involved in the oncogenesis of odontogenic epithelium. The expression of amelogenin is possibly an indicator of differentiation of epithelial cells in the odontogenic tumors. Aim of the study: Investigating the expression of amelogenin in some odontogenic tumors, using an anti-amelogenin polyclonal antibody, and then compare it with AMEL expression in tooth buds as control...
May 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29791200/evaluation-of-mandibular-odontogenic-keratocyst-and-ameloblastoma-by-panoramic-radiograph-and-computed-tomography
#8
Daniel Berretta Moreira Alves, Fabrício Mesquita Tuji, Fábio Abreu Alves, André Caroli Rocha, Alan Roger Dos Santos-Silva, Pablo Agustin Vargas, Márcio Ajudarte Lopes
OBJECTIVE: The purpose of this study was to describe and compare the main imagenological features of mandibular ameloblastomas and odontogenic keratocyst (OKC) using panoramic radiograph (PR) and computed tomography (CT). METHODS: The sample consisted of 9 cases of ameloblastomas and 9 cases of OKC. PR and CT images were analyzed according to shape, internal structure, borders, associated unerupted tooth, root resorption, expansion and perforation of cortical bones...
May 23, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29731577/expression-of-ki-67-in-odontogenic-cysts-a-comparative-study-between-odontogenic-keratocysts-radicular-cysts-and-dentigerous-cysts
#9
Tapan G Modi, Monali Chalishazar, Malay Kumar
Introduction and Objectives: Odontogenic cysts are the most common cysts of the jaws and are formed from the remnants of the odontogenic apparatus. Among these odontogenic cysts, radicular cysts (RCs) (about 60% of all diagnosed jaw cysts), dentigerous cysts (DCs) (16.6% of all jaw cysts) and odontogenic keratocysts (OKCs) (11.2% of all developmental odontogenic cysts) are the most common. The behavior of any lesion is generally reflected by its growth potential. Growth potential is determined by measuring the cell proliferative activity...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29706474/a-series-of-240-odontogenic-keratocysts-should-we-continue-to-use-the-terminology-of-keratocystic-odontogenic-tumour-for-the-solid-variant-of-odontogenic-keratocyst
#10
Devrim Kahraman, Omer Gunhan, Bulent Celasun
Most of the odontogenic keratocysts show an indolent behaviour like non-neoplastic lesions. For this reason, the odontogenic keratocyst was reclassified within the odontogenic cysts category in the WHO 2017 classification. Some odontogenic keratocysts may contain satellite cysts or solid squamoid islands within their wall. Recently, a solid form of odontogenic keratocyst has also been described which is composed entirely of multiple epithelial islands and small cysts in a collagenous stroma. The true nature of this variant is unclear yet...
June 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29672163/an-unusual-case-of-an-odontogenic-keratocyst-associated-with-an-ungrafted-alveolar-cleft-a-case-report-and-review-of-the-literature
#11
Sapna Radia, Alexander C Cash, Kanwalraj Moar
We describe an unusual case of an odontogenic keratocyst (OKC) associated with an ungrafted left-sided alveolar cleft in a 10-year-old male patient. There is no previous report in the literature of OKC or other dental cysts associated with an alveolar cleft. We discuss the management of the OKC prior to secondary bone grafting and present this case to highlight the difficulty in the management of OKC concurrent with grafting of the alveolar cleft site, the proximity of unerupted permanent teeth, and possible treatment modalities...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29657523/comparison-of-osteoclastogenesis-and-local-invasiveness-of-ameloblastoma-and-keratocystic-odontogenic-tumor
#12
Natheer H Al-Rawi, Ammar K Al-Siraj, Ahlam H Majeed
Objectives: The aim of this study was to compare the expression of receptor-activated nuclear factor kappa B (RANK) with its ligand (RANKL) and matrix metalloproteinase-2 (MMP2) in solid/multicystic ameloblastomas (ABs) and keratocystic odontogenic tumors (KOTs). Materials and Methods: The expression of MMP2, RANK, and RANKL molecules was evaluated in 13 ABs and 14 KOTs by immunohistochemistry. The expressions were calculated in the odontogenic epithelial cells as well as the stromal cells...
January 2018: European Journal of Dentistry
https://www.readbyqxmd.com/read/29621081/odontogenic-keratocysts-as-first-manifestation-of-nevoid-basal-cell-carcinoma-syndrome-surgical-management-and-immunohistochemical-analysis
#13
Jessica Luana Dos Santos, Renata Zoraida Rizental Delgado, Greison Rabelo de Oliveira, Ana Lúcia Carrinho Ayroza Rangel
Nevoid Basal Cell Carcinoma Syndrome (NBCCS), also known as Gorlin syndrome, is a rare autosomal dominant disorder, with no gender predilection. Individuals with NBCCS are commonly diagnosed between 17 and 35 years old and can present multiple basal cell carcinomas scattered throughout the body, presence of recurrent and early-onset odontogenic keratocysts (OKCs) and skeletal abnormalities. This article describes a case of a 13-year-old white boy who referred complaining of facial asymmetry. Extraoral examination revealed volumetric increase displacing the nasal ala from the right side and extended to the zygomatic bone...
April 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29620170/increased-level-of-cell-derived-microparticles-in-the-cyst-fluids-of-odontogenic-keratocysts
#14
Qi-Wen Man, Wen-Qun Zhong, Jian-Gang Ren, Jin-Yuan Liu, Yue-Yu Zheng, Rui-Fang Li, B Fidele Nyimi, Gang Chen, Yi-Fang Zhao, Bing Liu
The aim of this study was to examine the level and basic characteristics of cell‑derived microparticles (MPs) in the cyst fluids of odontogenic keratocysts (OKCs). For this purpose, MPs from the cyst fluids (CFMPs) of OKCs were purified by a classic differential centrifugation method and characterized by a transmission electron microscope and fluorescence microscope. Flow cytometric analysis was used to determine the size, concentration and cellular origins of the CFMPs. Moreover, the expression level of receptor activator for nuclear factor‑κB ligand in the OKCs was evaluated by immunohistochemical staining and then analyzed for its correlation with the concentration of CFMPs by Spearman's rank correlation test...
June 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29577431/is-podoplanin-expression-associated-with-transforming-growth-factor-%C3%AE-signaling-in-odontogenic-cysts-and-tumors
#15
Shahroo Etemad-Moghadam, Mojgan Alaeddini
BACKGROUND: Induction of podoplanin by transforming growth factor-β (TGF-β) has been shown in a number of lesions but not in odontogenic tumors (OTs). We evaluated the association between these markers in OTs for the first time and compared their expression among the different neoplasms. METHODS: Immunohistochemistry using monoclonal antibody against podoplanin and TGF-β was performed on 76 odontogenic cysts and tumors. Spearman's correlation coefficient, Kruskal-Wallis, and Mann-Whitney U tests followed by adjustment with Bonferroni were used for statistical analysis (P < ...
May 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29564556/immunohistochemical-evaluation-of-sonic-hedgehog-signaling-pathway-proteins-shh-ptch1-ptch2-smo-gli1-gli2-and-gli3-in-sporadic-and-syndromic-odontogenic-keratocysts
#16
Ana Maria Hoyos Cadavid, E Kaminagakura, M F S D Rodrigues, C A L Pinto, T H N Teshima, F A Alves
AIMS: The aim of this study was to compare the clinical and demographic features of 62 patients presenting sporadic odontogenic keratocysts (OKCs) or OKCs associated with nevoid basal cell carcinoma syndrome (NBCCS). In conjunction with this, we also evaluated the immunohistochemical expression of Shh, Ptch1, Ptch2, Smo, Gli1, Gli2 and Gli3 proteins in 86 OKCs. By doing this, we add to the understanding of the biology of this type of lesion, providing tools that will help facilitate the early diagnosis of NBCCS in those patients where the first manifestation is that of OKCs...
March 21, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29544218/a-novel-ptch1-frameshift-mutation-leading-to-nevoid-basal-cell-carcinoma-syndrome
#17
Ceren D Durmaz, Gareth Evans, Miriam J Smith, Pelin Ertop, Bengü N Akay, Timur Tuncalı
Nevoid basal cell carcinoma syndrome (NBCCS), also known as Gorlin syndrome, is a rare multisystemic autosomal dominant disorder typically presenting with cutaneous basal cell carcinomas, multiple keratocysts, and skeletal anomalies. NBCCS is caused by heterozygous mutations in the PTCH1 gene in chromosome 9q22, in the PTCH2 gene in 1p34, or the SUFU gene in 10q24.32. Here, we report on an 18-month-old boy presenting with medulloblastoma, frontal bossing, and multiple skeletal anomalies and his father who has basal cell carcinomas, palmar pits, macrocephaly, bifid ribs, calcification of falx cerebri, and a history of surgery for odontogenic keratocyst...
2018: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29543044/the-use-of-dual-nasal-trumpet-stents-to-decompress-keratocystic-odontogenic-tumours
#18
S Al-Benna, T G Arayathinal
No abstract text is available yet for this article.
March 15, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29530737/clinical-characteristics-and-immunohistochemical-analysis-of-p53-ki-67-and-cyclin-d1-in-80-odontogenic-keratocysts
#19
C Doll, K Dauter, K Jöhrens, S Hartwig, J O Voss, M Klein, M Heiland, J-D Raguse
OBJECTIVE: The aim of this study was to evaluate clinical parameters and expression patterns of Ki-67, cyclin D1 and p53 in odontogenic keratocysts. MATERIAL AND METHODS: In this study, fifty-three patients with 80 odontogenic keratocysts were included. The medical records of these patients were reviewed retrospectively. To elucidate the molecular pathogenesis of the disease, the expression of p53, Ki-67 and cyclin D1 was analyzed using immunohistochemistry. RESULTS: A total of 53 patients (mean age 38 years) with a median follow-up of 4...
March 9, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29521748/delayed-diagnosis-of-gorlin-goltz-syndrome-the-importance-of-the-multidisciplinary-approach
#20
Jéssica Araújo Figueira, Fábio Roberto de Souza Batista, Karina Rosso, Vanessa Cristina Veltrini, Angelo José Pavan
Gorlin-Goltz syndrome (GGS), also known as nevoid basal cell carcinoma syndrome, is an autosomal dominant inherited disorder with high penetrance and variable expressivity. The classic triad originally described by Gorlin and Goltz in 1960 is composed of multiple nevoid basal cell carcinomas (NBCCs), odontogenic keratocysts (OKCs) in the jaws and bifid ribs. in 1977, this triad was modified by Rayner et al, and to GGS diagnosis, the OKCs had to appear in combination with calcification of the cerebellar falx or palmar and plantar pits...
March 8, 2018: Journal of Craniofacial Surgery
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