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Odontogenic keratocyst

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https://www.readbyqxmd.com/read/28797453/oncogenic-signalling-pathways-in-benign-odontogenic-cysts-and-tumours
#1
REVIEW
Marina Gonçalves Diniz, Carolina Cavalieri Gomes, Sílvia Ferreira de Sousa, Guilherme Machado Xavier, Ricardo Santiago Gomez
The first step towards the prevention of cancer is to develop an in-depth understanding of tumourigenesis and the molecular basis of malignant transformation. What drives tumour initiation? Why do most benign tumours fail to metastasize? Oncogenic mutations, previously considered to be the hallmark drivers of cancers, are reported in benign cysts and tumours, including those that have an odontogenic origin. Despite the presence of such alterations, the vast majority of odontogenic lesions are benign and never progress to the stage of malignant transformation...
September 2017: Oral Oncology
https://www.readbyqxmd.com/read/28761644/an-extensive-swelling-in-the-anterior-mandible-a-case-report
#2
Nikhil M Kurien, L K Surej Kumar, P B Uma, V Vivek, Anna P Joseph
INTRODUCTION: Glandular odontogenic cyst is a rare developmental odontogenic cyst, which often pose a challenge to diagnose it clinically. PRESENTATION OF A CASE: A 32 year old female patient was referred to the oral and maxillofacial surgery department with a chief complaint of a painless swelling in the anterior mandible, extending from mandibular left premolar to right first molar region, with fluctuancy and egg shell crackling at right premolar region. The associated teeth were firm...
September 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28761280/recurrent-keratocystic-odontogenic-tumor-of-right-maxillary-sinus-involving-the-right-infraorbital-rim
#3
Karthikeyan Maruthamuthu, G Vasupradha, Janardhanam Dineshshankar, Abishek Rajaram Balaji
Keratocystic odontogenic tumor (KCOT) is a benign odontogenic tumor with an aggressive behavior and high recurrence rate. The most common site of predilection is the posterior mandible. In contrast, KCOTs occurring in the maxillary region are relatively rare. However, the maxillary involvement poses a greater and increased threat, due to proximity to vital structures such as maxillary sinus, orbital floor, and infratemporal fossa. This report presents such a case of KCOT involving the maxillary sinus eroding the floor of the orbit and provides an account of the factors that need to be considered during management...
January 2017: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28755796/significant-association-of-inflammation-grade-with-the-number-of-langerhans-cells-in-odontogenic-keratocysts
#4
Chun-Han Chang, Yang-Che Wu, Yu-Hsueh Wu, Andy Sun, Shih-Jung Cheng, Hsin-Ming Chen
BACKGROUND/PURPOSE: Langerhans cells (LCs) are antigen-presenting cells. This study assessed the LC counts in odontogenic keratocysts (OKCs). METHODS: The LC numbers in the lining epithelia and subepithelial connective tissues were counted at 60 OKC sites without inflammation, 39 OKC sites with mild/moderate inflammation, and 13 OKC sites with severe inflammation from 60 OKC specimens immunostained with anti-S100 antibodies. RESULTS: The mean LC counts in the lining epithelia and subepithelial connective tissues increased significantly from no inflammation (0...
July 26, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28721991/angiogenesis-concept-in-odontogenic-keratocyst-a-comparative-study
#5
Donia Sadri, Fatemeh Shahsavari, Sareh Farhadi, Zahra Shahabi, Zahra Mehran
CONTEXT: Recent reports have indicated that angiogenesis possibly affects the biologic behavior of the lesions. AIM: Given the different clinical behaviors of odontogenic keratocyst (OKC), the present study was undertaken to evaluate the concept of angiogenesis in pathogenesis and clinical behavior of OKC. SETTING AND DESIGN: This experimental study was carried out on 22 and 24 samples of OKCs and dentigerous cysts (DCs), respectively. METHODS: Immunohistochemical staining was approached using CD34 and vascular endothelial growth factor (VEGF) antibodies...
May 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28716472/the-bone-lid-technique-in-oral-surgery-a-case-series-study
#6
S Sivolella, G Brunello, F Fistarol, E Stellini, C Bacci
The aim of this case series study was to illustrate the bone lid technique implemented using piezoelectric surgery to access mandibular alveolar bone diseases and to assess the clinical and radiographic outcomes. The technique was used to treat 21 consecutive patients with various conditions: cysts in six cases, impacted teeth with associated cysts in nine, keratocystic odontogenic tumours in three, impacted teeth in two, and an endodontic lesion in one. The bone lid was fashioned using piezoelectric surgery and a thin osteotomy insert...
July 14, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28713753/removal-of-multiple-keratocystic-odontogenic-tumors-in-a-nonsyndromic-patient
#7
Artur Cunha Vasconcelos, Paulo Henrique de Souza Castro, Alvaro Henrique Borges, Luiz Evaristo Ricci Volpato
Multiple keratocystic odontogenic tumors are one of the key features of Gorlin-Goltz syndrome. A 15-year-old nonsyndromic female child presented with multiple keratocystic odontogenic tumors. The presence of the tumors was observed in immunological examinations. The images led to the suspicion of Gorlin-Goltz syndrome which was discarded after analyzing the patient's medical history and complementary examinations. Le Fort I osteotomy was opted to access the maxillary tumors favoring visibility and allowing simultaneous bilateral accesses...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28713736/using-carnoy-s-solution-in-treatment-of-keratocystic-odontogenic-tumor
#8
Najwa Jameel Alchalabi, Ahmed Maki Merza, Sabah Abdulaziz Issa
AIM: The aim of this study was to assess the treatment of keratocystic odontogenic tumor using enucleation and Carnoy's solution with peripheral ostectomy. MATERIALS AND METHODS: Twenty-nine patients (14 females and 15 males) with age range from 12 to 62 years were included in this study and followed up for 7 years; all the patients were treated in the Department of Oral and Maxillofacial Surgery of the Specialized Surgeries Teaching Hospital (Al-Shaheed Ghazi Al-Hariri Hospital-Medical City, Baghdad, Iraq)...
January 2017: Annals of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28706783/the-anecdote-of-viral-etiopathogenia-in-ameloblastoma-and-odontogenic-keratocyst-why-don-t-we-let-it-go
#9
Bacem A E O Khalele
BACKGROUND: Ameloblastoma (AM) and odontogenic Keratocyst (OKC) are destructive odontogenic lesions of the gnathion. Although their exact pathogeneses are not yet totally understood, the viral etiopathogenesis in AM and KCOT has been proposed. True to syndromic keratocystic odontogenic tumor (sKCOT) and non-syndromic OKC is the high recurrence rate. OBJECTIVES: Given that shared pathways trailed by AM and by sKCOT/OKC have been suggested, this study, however, contrasts the expression of AM and OKC for viral antibodies...
May 2017: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/28700034/application-of-endoscopy-to-treat-mandibular-keratocystic-odontogenic-tumors
#10
Z Gao, Q W Ni, W Gao, Y P Liu, Q Zhang
The aim of this study was to evaluate the feasibility of endoscopy to remove keratocystic odontogenic tumors (KCOTs) with virtual 3D mandibular images. Fifteen patients (mean age, 40.27±14.58 years) who underwent endoscopic mandibular KCOT enucleation between May 2009 and October 2009 were included. Virtual 3D mandibular reconstructions derived from computed tomography (CT) imaging were generated for all patients. Recurrence and pathological fracture were evaluated as the primary outcome variables at 1 and 12 months after operation...
July 10, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28688493/computer-aided-diagnosis-of-periapical-cyst-and-keratocystic-odontogenic-tumor-on-cone-beam-computed-tomography
#11
E Yilmaz, T Kayikcioglu, S Kayipmaz
BACKGROUND AND OBJECTIVES: In this article, we propose a decision support system for effective classification of dental periapical cyst and keratocystic odontogenic tumor (KCOT) lesions obtained via cone beam computed tomography (CBCT). CBCT has been effectively used in recent years for diagnosing dental pathologies and determining their boundaries and content. Unlike other imaging techniques, CBCT provides detailed and distinctive information about the pathologies by enabling a three-dimensional (3D) image of the region to be displayed...
July 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28680851/squamous-cell-carcinoma-arising-within-a-maxillary-odontogenic-keratocyst-a-rare-occurrence
#12
Elnaz Jalali, Elie M Ferneini, Kandasamy Rengasamy, Aditya Tadinada
Squamous cell carcinoma (SCC) arising within the lining of an odontogenic keratocyst (OKC) is a rare occurrence. Although potentially locally destructive, OKC is a benign odontogenic process that typically presents with clinical and radiographic features characteristic of a benign intraosseous neoplasm. We present the clinical and radiographic features of a maxillary mass that demonstrated SCC arising from the lining of an OKC. Although the initial clinical and radiographic presentation suggested an infection or malignant neoplasm, biopsies revealed an infiltrative well-differentiated SCC contiguous with and arising from the focus of a pre-existing OKC...
June 2017: Imaging Science in Dentistry
https://www.readbyqxmd.com/read/28674741/new-tumour-entities-in-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumours-odontogenic-and-maxillofacial-bone-tumours
#13
REVIEW
Paul M Speight, Takashi Takata
The latest (4th) edition of the World Health Organization Classification of Head and Neck tumours has recently been published with a number of significant changes across all tumour sites. In particular, there has been a major attempt to simplify classifications and to use defining criteria which can be used globally in all situations, avoiding wherever possible the use of complex molecular techniques which may not be affordable or widely available. This review summarises the changes in Chapter 8: Odontogenic and maxillofacial bone lesions...
July 3, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28650783/conservative-treatment-of-multiple-keratocystic-odontogenic-tumors-in-a-young-patient-with-nevoid-basal-cell-carcinoma-syndrome-by-decompression-a-7-year-follow-up-study
#14
Su-Hyun Kim, Min-Seok Oh, Yo-Seob Seo, Jin-Young Kim, Soon-Hyeun Nam, Su-Min Lim
Multiple keratocystic odontogenic tumors (KCOT) occurred in a young child is challenging problem in the field of pediatric dentistry, and might have been related to nevoid basal cell carcinoma syndrome (NBCCS). Because of high recurrence rate of KCOTs, complete surgical resection is generally accepted as definitive treatment. However, complete surgical resection could induce negative effect on the development of permanent teeth and growth of jaw. Herein, we reported successful treatment case of young KCOT patient with NBCCS...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28635992/odontogenic-tumors-a-retrospective-clinicopathological-study-from-two-italian-centers
#15
C Rubini, M Mascitti, A Santarelli, A Tempesta, L Limongelli, G Favia, E Maiorano
Objective: The aim of this retrospective study was to perform an epidemiological analysis of all odontogenic tumors treated in the University Hospitals "Ospedali Riuniti" in Ancona and "Policlinico" in Bari, from 1990 to 2015. Materials and methods: A retrospective survey of 277 patients treated for odontogenic tumors from 1990 to 2015 was performed. Data were retrieved from the archives of the above quoted Sections of Pathology. The lesions were classified according to 2005 WHO histological classification, and the following variables were analyzed: age, sex, histopathological diagnosis, site distribution, tumor size, and relapses...
March 2017: Pathologica
https://www.readbyqxmd.com/read/28628158/-effects-of-ptch1-mutations-on-the-epithelial-proliferation-derived-from-keratocystic-odontogenic-tumour
#16
(no author information available yet)
OBJECTIVE: To explore the relationship between the PTCH1 mutation and the expression of bcl-2, filaggrin, and loricrin in the keratocystic odontogenic tumour (KCOT), as well as the effects of the mutated PTCH1 on the epithelial proliferation and differentiation. METHODS: The samples were collected from 20 cases of KCOT with mutated PTCH1, as well as 20 cases without mutation. All the samples were analyzed with immunohistochemical staining, for the purpose of investigating the expression of bcl-2, filaggrin, and loricrin...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28611319/assessing-alpha-tocopherol-levels-in-patients-with-keratocystic-odontogenic-tumor-a-cross-sectional-study
#17
Bhargavi Krishna Ayinampudi, Sushmita Bhargavi Varikoti, Pacha Venkat Baghirath, B Hari Vinay, Ch Gayathri, Ashalata Gannepalli
AIMS AND OBJECTIVES: A keratocystic odontogenic tumour (KCOT) is a benign uni- or multicystic, intraosseous tumour of odontogenic origin, with a characteristic lining of parakeratinized stratified squamous epithelium and potential for aggressive, infiltrative behaviour. Various studies in hamsters showed that, alpha-Tocopherol, which is an active biological form of Vitamin E, is a potent antioxidant known to inhibit tumour formation and also regression of established tumours. So, the aim of the present pilot study was to assess the levels of Alpha-Tocopherol(Vitamin E) in Patients with KCOT and compare them with Vitamin E levels in normal healthy individuals...
March 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28584604/p53-protein-expression-in-dental-follicle-dentigerous-cyst-odontogenic-keratocyst-and-inflammatory-subtypes-of-cysts-an-immunohistochemical-study
#18
Mashhadiabbas Fatemeh, Arab Sepideh, Bagheri Seyedeh Sara, Mahdavi Nazanin
OBJECTIVES: An odontogenic keratocyst (OKC) is a developmental odontogenic cyst with aggressive clinical behavior. This cyst shows a different growth mechanism from the more common dentigerous cyst and now has been renamed as a keratocystic odontogenic tumor (KCOT). Inflammation can assist tumor growth via different mechanisms including dysregulation of the p53 gene. This study aims to assess and compare the expression of tumor suppressor gene p53 in inflamed and non-inflamed types of OKC and dentigerous cyst...
May 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28521454/histopathological-and-immunohistochemical-study-in-keratocystic-odontogenic-tumors-predictive-factors-of-recurrence
#19
Tomofumi Naruse, Kentaro Yamashita, Souichi Yanamoto, Satoshi Rokutanda, Yuki Matsushita, Yuki Sakamoto, Hiroshi Sakamoto, Hisazumi Ikeda, Tohru Ikeda, Izumi Asahina, Masahiro Umeda
The aim of the present study was to identify the most useful markers for predicting recurrence of keratocystic odontogenic tumors (KCOTs). A total of 65 tumor samples from 63 patients diagnosed with typical parakeratinized cysts and KCOTs between 1992 and 2014 were retrospectively studied. Clinical and histopathological data and treatment modality were reviewed. In addition, the expression profiles of Ki-67, cluster of differentiation (CD)34 and podoplanin were assessed using immunohistochemistry. The association between these factors and the rate of KCOT recurrence was evaluated...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28512636/expression-of-yap-taz-in-keratocystic-odontogenic-tumors-and-its-possible-association-with-proliferative-behavior
#20
Qi-Wen Man, Yan-Qi Ma, Jin-Yuan Liu, Yi Zhao, Bing Liu, Yi-Fang Zhao
The aim of this study is to clarify whether YAP/TAZ is involved in the pathogenesis and proliferative growth of keratocystic odontogenic tumor (KCOT). The expression levels of YAP/TAZ and downstream proteins and genes in normal oral mucosa (OM) and KCOT were determined and compared by immunohistochemistry and real-time quantitative PCR. The results showed that the expression of YAP/TAZ and downstream proteins (Cyr61, CTGF) was significantly upregulated in KCOT with upregulation of Ki-67 compared to OM. Importantly, the mRNA levels of transcription factors (TEAD1, TEAD4, and RUNX2) and cell cycle related genes (CDK2, PCNA), which interact with the transcriptional coactivators YAP/TAZ, are also upregulated in the KCOT...
2017: BioMed Research International
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