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https://www.readbyqxmd.com/read/29336522/continued-root-maturation-despite-persistent-apical-periodontitis-of-immature-permanent-teeth-after-failed-regenerative-endodontic-therapy
#1
Louis M Lin, Sahng G Kim, Gabriela Martin, Bill Kahler
Three immature permanent teeth with pulp necrosis and apical periodontitis were treated with regenerative endodontic therapy (RET), which included root canal disinfection with sodium hypochlorite irrigation, intra-canal medication with calcium hydroxide paste, 17% EDTA rinse, induction of periapical bleeding into the canal, collagen matrix and MTA coronal seal, and composite resin restoration of access cavities. After different periods of follow-up, it was observed that continued root maturation, especially apical closure occurred despite persistent apical periodontitis of immature permanent teeth after failed RET...
January 16, 2018: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/29285027/comparison-of-the-level-of-substance-p-and-neurokinin-a-in-gingival-crevicular-fluid-of-sound-and-symptomatic-carious-primary-teeth-by-elisa
#2
Alireza Heidari, Mehdi Shahrabi, Marzieh Salehi Shahrabi, Mehdi Ghandehari, Pegah Rahbar
Objectives: Pulpal inflammation is often associated with odontogenic pain. Dental pulp is abundantly innervated with sensory fibers encompassing neuropeptides. Neurokinin A (NKA) and substance P (SP) are important neuropeptides in the dental pulp that can cause neurogenic inflammation. Since no previous study has assessed dental pulp neuropeptides in children, this study aimed to compare the level of NKA and SP in gingival crevicular fluid (GCF) of sound and symptomatic carious primary teeth...
July 2017: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/29230545/influence-of-different-types-of-light-on-the-response-of-the-pulp-tissue-in-dental-bleaching-a-systematic-review
#3
Francine Benetti, Cleidiel Aparecido Araújo Lemos, Marjorie de Oliveira Gallinari, Amanda Miyuki Terayama, André Luiz Fraga Briso, Rogério de Castilho Jacinto, Gustavo Sivieri-Araújo, Luciano Tavares Angelo Cintra
OBJECTIVES: This systematic review (PROSPERO register: CRD42016053140) investigated the influence of different types of light on the pulp tissue during dental bleaching. MATERIALS AND METHODS: Two independent authors conducted a systematic search and risk of bias evaluations. An electronic search was undertaken (PubMed/Medline, Embase, The Cochrane Library, and other databases) until May 2017. The population, intervention, comparison, outcomes (PICO) question was: "Does the light in dental bleaching change the response of the pulp to the bleaching procedure?" The intervention involved pulp tissue/cells after bleaching with light, while the comparison involved pulp tissue/cells after bleaching without light...
December 11, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29207830/assessment-of-pulp-oxygen-saturation-levels-by-pulse-oximetry-for-pulpal-diseases-a-diagnostic-study
#4
Bander Anusha, Koppolu Madhusudhana, Suneel Kumar Chinni, Yelloji Paramesh
Introduction: Diagnosis of pulpal inflammation is a key to endodontics. Pulse oximetry is a true vitality testing device which relies on oxygen saturation levels of pulp and helps in diagnosis of different pulpal conditions. Aim: The aim of the study was to analyse oxygen saturation levels of different pulpally inflamed teeth by using pulse oximetry. Materials and Methods: Hundred patients were included in the study and categorized into five groups based on pulpal status of the test tooth by using heat test and cold test...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29199328/-expression-of-human-%C3%AE-defensin-and-its-relationship-with-inflammatory-factor-in-human-dental-pulp-tissue
#5
Zhai Yue, Jian-Ying Huang, Park Hyun, Fang Ji, Zhao-Liang Fei, Jiang Tao
PURPOSE: To investigate the expression of human β-defensin(HBD) in human dental pulp tissue and to explore the regulation of HBD in pulp inflammation and the relationship among HBD family members. METHODS: The gene expression of HBD in human dental pulp tissue was assessed in NCBI GEO profiles and was verified by RT-PCR. Human dental pulp cells were stimulated with TNF-α, IL-1α, IL-1β and IL-6 in different combinations and the expression of HBD2 was analyzed by qPCR...
August 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/29186939/periapical-abscess-%C3%A2-etiology-pathogenesis-and-epidemiology
#6
Aleksandra Burczyńska, Izabela Strużycka, Łukasz Dziewit, Marta Wróblewska
Inflammation of the pulp and periapical tissues is the main cause of tooth loss in patients worldwide, therefore endodontics is one of the most rapidly developing specialties in dentistry. Despite proper endodontic treatment, in many cases it is not possible to determine the etiology of infection or the reason for its relapse. Many research studies indicate that infections of the periapical tissues are mainly caused by strictly anaerobic bacteria. At present, more and more often the composition of the microflora within the inflammatory lesions is being evaluated with the use of molecular techniques, which showed that classical culture methods are not able to determine the etiology of infections of the periapical tissues...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29165324/in-vivo-evaluation-of-modified-silk-fibroin-scaffolds-with-a-mimicked-microenvironment-of-fibronectin-decellularized-pulp-tissue-for-maxillofacial-surgery
#7
Thanh H Thai, Thongchai Nuntanaranont, Suttatip Kamolmatyakul, Jirut Meesane
This study aimed to carry out in vivo testing of the formation of new bone by modified silk fibroin scaffolds with a mimicked microenvironment of fibronectin/decellularized pulp in bone defects. Silk fibroin scaffolds were fabricated into three-dimensional scaffolds before being coated with fibronectin/decellularized pulp. The coated scaffolds were implanted into rabbits. Twenty-four bicortical calvarial defects in 12 rabbits were divided randomly into two groups: non-coated and coated silk fibroin scaffolds...
November 22, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29132068/secretoneurin-and-pe-11-immunoreactivity-in-the-human-dental-pulp
#8
René Steiner, Reiner Fischer-Colbrie, Athanasia Bletsa, Johannes Laimer, Josef Troger
OBJECTIVE: To explore whether there are differences in the concentration of the secretogranin II-derived peptide secretoneurin and the chromogranin B-derived peptide PE-11 between the healthy and inflamed human dental pulps. Furthermore, colocalization studies with calcitonin gene-related peptide were performed to confirm the sensory origin of the peptidergic nerves in the dental pulp. DESIGN: The concentrations of secretoneurin and PE-11 were determined by highly sensitive radioimmunoassays in extracts of dental pulps, the molecular form of secretoneurin immunoreactivities by RP-HPLC with subsequent radioimmunoassay and colocalization studies with calcitonin gene-related peptide were performed by double immunofluorescence...
November 9, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29131694/role-of-neuron-glial-interaction-mediated-by-il-1%C3%AE-in-ectopic-tooth-pain
#9
H Komiya, K Shimizu, N Noma, Y Tsuboi, K Honda, K Kanno, K Ohara, M Shinoda, B Ogiso, K Iwata
Although many reports have demonstrated that ectopic pain develops in the orofacial region following tooth pulp inflammation, which often causes misdiagnosis and inappropriate treatment for patients with pulpitis, the precise mechanism remains unknown. In the present study, we hypothesized that the functional interaction between satellite glial cells and neurons mediated by interleukin 1β (IL-1β) in the trigeminal ganglion (TG) is involved in ectopic orofacial pain associated with tooth pulp inflammation...
November 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29081820/antihypercholesterolemic-effects-of-fruit-aqueous-extract-of-copernicia-prunifera-miller-h-e-moore-in-mice-diet-induced-hypercholesterolemia
#10
Raquel Teixeira Terceiro Paim, Stephen Rathinaraj Benjamin, Davide Rondina, Márcia Maria Mendes Marques, Daniel de Araújo Viana, Maria Leônia da Costa Gonzaga, Ícaro Gusmão Pinto Vieira, Francisca Noélia Pereira Mendes, Paula Alves Salmito Rodrigues, Maria Izabel Florindo Guedes
The present objective of the investigation is to evaluate the antihypercholesterolemic activity of the aqueous fruit pulp extract (APE) of Copernicia prunifera (Miller) H. E. Moore (Arecaceae family). Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy, (1)H and (13)C NMR, and molecular weight by gel permeation chromatography have been employed to characterize the extracted pectin. The present study demonstrated that hypercholesterolemic diet (HD) created hypercholesterolemia, caused significant increases in body weight, total cholesterol, and low-density lipoprotein, and caused decreases in high-density lipoprotein in serum compared with SD group...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29079059/differential-expression-of-long-noncoding-rnas-in-normal-and-inflamed-human-dental-pulp
#11
Xin Huang, Ke Chen
INTRODUCTION: Dental pulp inflammation is an excellent model for the interaction between tissue inflammation and regenerative processes. It is worthwhile to better understand molecular signaling of repair and regeneration in inflammatory processes. Emerging evidence suggests that long noncoding RNA (lncRNA) participates in immune system inflammatory processes. Here we investigate the expression of lncRNAs in pulpitis, the inflammation of dental pulp tissue, and identify lncRNAs that possibly participate in inflammation responses and odontogenesis...
October 24, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29079049/evaluation-of-the-periodontal-disease-effect-on%C3%A2-pulp-volume
#12
Arslan Terlemez, Raif Alan, Onur Gezgin
INTRODUCTION: The success of periodontal and endodontic treatments depends on the total recovery from both conditions regardless of their occurrence as independent or combined lesions. There is strong presumptive evidence that teeth with periodontal disease may cause pulpal inflammation and degeneration. Therefore, the goal of this study was to establish a correlation between periodontitis and pulp volume. METHODS: Thirty-four dental images from 17 patients obtained by cone-beam computed tomography were analyzed by medical software to create three-dimensional images...
October 24, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29069143/factors-affecting-the-periapical-healing-process-of-endodontically-treated-teeth
#13
Roberto Holland, João Eduardo Gomes, Luciano Tavares Angelo Cintra, Índia Olinta de Azevedo Queiroz, Carlos Estrela
Tissue repair is an essential process that reestablishes tissue integrity and regular function. Nevertheless, different therapeutic factors and clinical conditions may interfere in this process of periapical healing. This review aims to discuss the important therapeutic factors associated with the clinical protocol used during root canal treatment and to highlight the systemic conditions associated with the periapical healing process of endodontically treated teeth. The antibacterial strategies indicated in the conventional treatment of an inflamed and infected pulp and the modulation of the host's immune response may assist in tissue repair, if wound healing has been hindered by infection...
September 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29041775/lychee-litchi-chinensis-sonn-pulp-phenolic-extract-provides-protection-against-alcoholic-liver-injury-in-mice-by-alleviating-intestinal-microbiota-dysbiosis-intestinal-barrier-dysfunction-and-liver-inflammation
#14
Juan Xiao, Ruifen Zhang, Qiuyun Zhou, Lei Liu, Fei Huang, Yuanyuan Deng, Yongxuan Ma, Zhencheng Wei, Xiaojun Tang, Mingwei Zhang
Liver injury is the most common consequence of alcohol abuse, which is promoted by the inflammatory response triggered by gut-derived endotoxins produced as a consequence of intestinal microbiota dysbiosis and barrier dysfunction. The aim of this study was to investigate whether modulation of intestinal microbiota and barrier function, and liver inflammation contributes to the hepatoprotective effect of lychee pulp phenolic extract (LPPE) in alcohol-fed mice. Mice were treated with an ethanol-containing liquid diet alone or in combination with LPPE for 8 weeks...
October 27, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29032813/light-cured-tricalcium-silicate-toxicity-to-the-dental-pulp
#15
Charlotte Jeanneau, Patrick Laurent, Charlotte Rombouts, Thomas Giraud, Imad About
INTRODUCTION: Numerous studies reported dentin bridge formation after pulp capping with tricalcium silicates. By contrast, pulp capping with resins leads to pulp toxicity and inflammation. Hybrid materials made up of tricalcium silicates and resins have also been developed to be used in direct pulp capping. This work was designed to study the consequences of adding resins to tricalcium silicates by investigating TheraCal (BISCO, Lançon De Provence, France) and Biodentine (Septodont, Saint Maur des Fosses, France) interactions with the dental pulp...
October 9, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29028630/ezh2-regulates-dental-pulp-inflammation-by-direct-effect-on-inflammatory-factors
#16
Tianqian Hui, Peng A, Yuan Zhao, Jing Yang, Ling Ye, Chenglin Wang
OBJECTIVE: Pulpitis is a multi-factorial disease that could be caused by complex interactions between genetics, epigenetics and environmental factors. We aimed to evaluate the role of Enhancer of Zeste Homolog 2 (EZH2) in the inflammatory response of human dental pulp cells (HDPCs) and dental pulp tissues. METHODS: The expressions of inflammatory cytokines in HDPCs treated by EZH2 complex or EZH2 siRNA with or without rhTNF-α were examined by quantitative real-time polymerase chain reaction (q-PCR)...
October 7, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28983188/mango-supplementation-has-no-effects-on-inflammatory-mediators-in-obese-adults
#17
Shirley F Evans, Maureen Beebe, Maryam Mahmood, Sawanya Janthachotikun, Heba Eldoumi, Sandra Peterson, Mark Payton, Penelope Perkins-Veazie, Brenda J Smith, Edralin A Lucas
This pilot study examined the effects of freeze-dried mango (Mangifera indica L.) supplementation on anthropometric measurements, lipid parameters, and inflammatory mediators in obese individuals. A total of 20 obese (body mass index [BMI]: 30-35 kg/m(2)) adults (11 men and 9 women), aged 20 to 50 years, received 10 g/d of ground freeze-dried mango pulp for 12 weeks. Anthropometrics, lipids, and inflammatory mediators were assessed at baseline and after 12 weeks of mango supplementation. There were no differences between baseline and final visits in inflammatory mediators, lipids, diet, physical activity, and anthropometrics...
2017: Nutrition and Metabolic Insights
https://www.readbyqxmd.com/read/28951318/rapidly-progressive-course-of-trypanosoma-cruzi-infection-in-mice-heterozygous-for-hexamethylene-bis-acetamide-inducible-1-hexim1-gene
#18
Eduardo Mascareno, Raavi Gupta, Laura A Martello, Manya Dhar-Mascareno, Louis Salciccioli, Daniel Beckles, Michael G Walsh, Fabiana S Machado, Herbert B Tanowitz, M A Haseeb
Infection with Trypanosoma cruzi causes Chagas disease and results in myocardial inflammation and cardiomyopathy. Downregulated Hexim1 expression, as in Hexim1(+/-) mice, reduces cardiac inflammation and fibrosis following ischemic stress. We asked whether reduced expression of Hexim1 would also afford protection against T. cruzi-induced cardiomyopathy. C57BL/6J (wild type - WT) and Hexim1(+/-) mice were infected with sub-lethal doses of T. cruzi (Brazil strain), and cardiac function, serologic markers of inflammation and tissue pathology were examined...
September 22, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28914245/a-comparative-evaluation-of-clinical-and-radiographic-success-rate-of-pulpotomy-in-primary-molars-using-antioxidant-mix-and-mineral-trioxide-aggregate-an-in-vivo-1-year-follow-up-study
#19
Sommyta Kathal, Shilpi Gupta, Deepak P Bhayya, Ashish Rao, Amrita Pal Roy, Anubhuti Sabhlok
INTRODUCTION: Pulpotomy technique is most widely accepted clinical procedure for treating primary teeth with coronal pulp inflammation caused by caries with no involvement of the radicular pulp. AIM AND OBJECTIVE: The aim of the study was to evaluate the success and efficacy of mineral trioxide aggregate (MTA) and antioxidant mix as pulpotomy agents both clinically and radiographically. MATERIALS AND METHODS: A total of forty primary molars in children aged between 6 and 9 years, requiring for pulpotomy procedures, were selected...
October 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28898790/cytotoxicity-and-potential-anti-inflammatory-activity-of-velutin-on-raw-264-7-cell-line-differentiation-implications-in-periodontal-bone-loss
#20
Carlos Brito, Alexander Stavroullakis, Tatiane Oliveira, Anuradha Prakki
OBJECTIVES: Hypoxia-inducible factor-1α (HIF-1α) has been implicated in periodontal tissue inflammation and possibly in osteoclast differentiation, while polyphenols are known to be anti-inflammatory natural compounds that are capable of regulating the NF-κB protein complex pathway. The objective of this study was to investigate cytotoxicity and HIF-1α expression through the NF-κB pathway by polyphenol velutin (Euterpe oleracea Mart.), found in the pulp of acai fruit, during inflammatory RAW 264...
September 2, 2017: Archives of Oral Biology
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