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https://www.readbyqxmd.com/read/29760738/dental-mesenchymal-stem-stromal-cells-and-their-exosomes
#1
REVIEW
Peter Stanko, Ursula Altanerova, Jana Jakubechova, Vanda Repiska, Cestmir Altaner
Stem cells derived from human dental pulp tissue (DP-MSC) differ from the other mesenchymal stem cells prepared from bone marrow or adipose tissue due to their embryonic origin from the neural crest and are of special interest because of their neurotropic character. Furthermore, the therapeutic potential of DP-MSCs is realized through paracrine action of extracellularly released components, for which exosomes play an important role. In this review, we intend to explore the properties of these cells with an emphasis on exosomes...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29758315/ameliorative-role-of-ferulic-acid-against-diabetes-associated-oxidative-stress-induced-spleen-damage
#2
Sumit Ghosh, Sayantani Chowdhury, Poulami Sarkar, Parames C Sil
Spleen, a secondary lymphoid organ, is the site of initiation of most of the immune responses. The present study is centered on the ameliorative role of ferulic acid against diabetic complications in the spleen of male wistar rats. Induction of diabetes by STZ (at a dose of 50 mg kg-1 body wt, i.p.) reduced the spleen size, plasma insulin level, enhanced the blood glucose level and disrupted the intracellular antioxidant machineries along with the depletion of splenic white pulp. Induction of oxidative stress mediated inflammation and apoptosis (upregulation in the levels of inflammatory cytokines, translocation of NF ĸB in the nucleus, alteration in Bax/Bcl-2 ratio, release of cytochrome c from mitochondria, activation of caspase-9 and 3, PARP cleavage and DNA fragmentation) were evidenced from immunoblot analyses, DNA fragmentation and TUNEL assay...
May 11, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29744721/the-evaluation-of-mta-and-biodentine-as-a-pulpotomy-materials-for-carious-exposures-in-primary-teeth
#3
Burcu Nihan Çelik, Merve Safa Mutluay, Volkan Arıkan, Şaziye Sarı
OBJECTIVE: This study examined the effects of MTA and Biodentine on the clinical and radiographic success rates of pulpotomies performed on primary teeth with carious pulp exposures. MATERIALS AND METHODS: This study was conducted with 44 mandibular primary molars requiring vital pulpotomy. Carious dentin surrounding the exposure site was used as the inclusion criteria for all teeth, which were randomly divided into two groups according to pulpotomy material [MTA group (n = 24), Biodentine group (n = 20)]...
May 10, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29737545/influence-of-apical-enlargement-on-the-repair-of-apical-periodontitis
#4
C M Jara, R C Hartmann, D E Böttcher, T S Souza, M S Gomes, J A P Figueiredo
AIM: To evaluate the influence of several apical enlargement protocols on the radiographic and histological healing of apical periodontitis in rats. METHODOLOGY: Apical periodontitis was induced bilaterally in the mandibular right and left first molars of 24 Wistar rats by pulp exposure to the oral cavity for three weeks. A standard serial root canal preparation technique was performed in the molar of one side, while the opposite side was the control group. Rats were randomly divided into three experimental groups (n=8), according to the diameter of apical enlargement during root canal preparation: K-files size 20 (EG1), size 25 (EG2), and size 30 (EG3)...
May 8, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29731560/immunohistochemical-quantification-of-mast-cells-in-inflamed-and-noninflamed-pulp-tissue
#5
G Dinakar, Arathi Ganesh, Ms Prem Kumar, Mythili Sabesan, Malathi Narasimhan, Kandaswamy Deivanayagam
Background: Dental pulp inflammation is a very complex process due to its situation in low compliance (confined environment) surrounded by mineralized dentin. Mast cells are one of the mediators of inflammation. Immunohistochemical localization of mast cells by anti-tryptase antibodies in formalin-fixed paraffin-embedded sections has been shown to be highly specific. The aim of the present study is to quantify the mast cells in inflamed and noninflamed human pulp tissue using immunohistochemical analysis...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29709340/il-1%C3%AE-induced-il-8-and-upa-expression-production-of-dental-pulp-cells-role-of-tak1-and-mek-erk-signaling
#6
Szu-I Lin, Li-Deh Lin, Hsiao-Hua Chang, Mei-Chi Chang, Yin-Lin Wang, Yu-Hwa Pan, Guay-Feng Huang, Hseuh-Jen Lin, Jiiang-Huei Jeng
BACKGROUND/PURPOSE: Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine involved in the inflammatory processes of dental pulp. IL-8 and urokinase plasminogen activator (uPA) are two inflammatory mediators. However, the role of transforming growth factor beta-activated kinase-1 (TAK1) and mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathways in responsible for the effects of IL-1β on IL-8 and uPA expression/secretion of dental pulp cells are not clear...
April 27, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29702010/pulp-regeneration-by-3-dimensional-dental-pulp-stem-cell-constructs
#7
Y Itoh, J I Sasaki, M Hashimoto, C Katata, M Hayashi, S Imazato
Dental pulp regeneration therapy for the pulpless tooth has attracted recent attention, and clinical trial studies are underway with the tissue engineering approach. However, there remain many concerns, including the extended period for regenerating the dental pulp. In addition, the use of scaffolds increases the risk of inflammation and infection. To establish a basic technology for novel dental pulp regenerative therapy that allows transplant of pulp-like tissue, we attempted to fabricate scaffold-free 3-dimensional (3D) cell constructs composed of dental pulp stem cells (DPSCs)...
April 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29680724/human-dental-pulp-cells-express-cellular-markers-for-inflammation-and-hard-tissue-formation-in-response-to-bacterial-information
#8
Akina Sugiuchi, Yousuke Sano, Masahiro Furusawa, Shu Abe, Takashi Muramatsu
INTRODUCTION: Lipopolysaccharide (LPS) is a major component of the outer membranes of gram-negative bacteria associated with deep dental caries and pulpitis. When bacteria invade dentinal tubes and dentin is continually destroyed, tertiary dentin is formed by preexisting odontoblasts. However, the relationship between LPS and tertiary dentin formation remains unclear. We investigated whether LPS stimulation induces the formation of hard tissue in human dental pulp cells (hDPCs). METHODS: Immortalized hDPCs were cultured, and Escherichia coli-derived LPS (1 μg/mL) was incorporated into the culture medium...
April 18, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29660488/changes-in-the-radicular-pulp-dentine-complex-in-healthy-intact-teeth-and-in-response-to-deep-caries-or-restorations-a-histological-and-histobacteriological-study
#9
Domenico Ricucci, Simona Loghin, Li-Na Niu, Franklin R Tay
INTRODUCTION: The present study reported the histological events that occurred in the radicular pulp of human mature teeth in the presence of medium/deep untreated caries lesions, and those teeth with restorations or direct pulp capping, with particular emphasis on the morphology of the canal wall dentine and the odontoblast layer. METHODS: Sixty-two teeth with medium/deep caries lesions, extensive restorations or after application of a direct pulp capping procedure were obtained from 57 subjects...
April 13, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29620442/mir-21-stat3-signal-is-involved-in-odontoblast-differentiation-of-human-dental-pulp-stem-cells-mediated-by-tnf-%C3%AE
#10
Ke Xu, Jingwen Xiao, Ke Zheng, Xingmei Feng, Jinlong Zhang, Donghui Song, Chenfei Wang, Xiang Shen, Xin Zhao, Changbo Wei, Dan Huang, Guijuan Feng
Dental pulp stem cells (DPSCs), as one type of mesenchymal stem cells (MSCs), have the capability of self-renewal and multipotency to differentiate into several cell lineages, including osteogenesis, odontoblasts, chondrogenesis, neurogenesis, and adipogenesis. It has found that tumor necrosis factor-α (TNF-α) can promote osteogenic differentiation of human DPSCs in our previous studies. Other experimentation revealed that signal transducer and activator of transcription 3 (STAT3) underwent a rapid activation both in osteogenesis and inflammation microenvironment of MSCs in vitro...
April 2018: Cellular Reprogramming
https://www.readbyqxmd.com/read/29551204/foxo3a-regulates-inflammation-induced-autophagy-in-odontoblasts
#11
Yuan Li, Haisheng Wang, Fei Pei, Zhi Chen, Lu Zhang
INTRODUCTION: FoxO3a is a member of FoxO transcription factor family that participates in the transcriptional regulation of autophagy. In this study we explored the anti-inflammatory function of FoxO3a-regulated autophagy in inflamed human dental pulp and lipopolysaccharide-treated mDPC6T cells. METHODS: The expression of FoxO3a and autophagy markers in caries and pulpitis from human dental pulp were examined by immunohistochemistry and Western blot. We conducted in vitro studies by treating mDPC6T cells with lipopolysaccharide for various lengths of time...
March 15, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29550006/ovariectomy-exacerbates-apical-periodontitis-in-rats-with-an-increase-in-expression-of-proinflammatory-cytokines-and-matrix-metalloproteinases
#12
Priscilla Coutinho Romualdo, Marília P Lucisano, Francisco Wanderley G Paula-Silva, Graziela B Leoni, Manoel D Sousa-Neto, Raquel Assed B Silva, Lea Assed B Silva, Paulo Nelson-Filho
INTRODUCTION: The aim of this study was to evaluate the gene expression of proinflammatory cytokines, matrix metalloproteinases (MMPs), and cathepsin K in apical periodontitis (AP) and the volume of lesions in ovariectomized and sham-operated rats. METHODS: Twenty 12-week-old female Wistar rats were subjected to ovariectomy (OVX) or sham surgery. After 9 weeks, access cavities were prepared in the maxillary and mandibular first molars, pulp tissue was removed, and canals were exposed to the oral environment during 21 days for the induction of AP...
March 14, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29545856/molecular-differences-between-mature-and-immature-dental-pulp-cells-bioinformatics-and-preliminary-results
#13
Long Chen, Yifeng Jiang, Zhen Du
Although previous studies have demonstrated that dental pulp stem cells (DPSCs) from mature and immature teeth exhibit potential for multi-directional differentiation, the molecular and biological difference between the DPSCs from mature and immature permanent teeth has not been fully investigated. In the present study, 500 differentially expressed genes from dental pulp cells (DPCs) in mature and immature permanent teeth were obtained from the Gene Expression Omnibus online database. Based on bioinformatics analysis using the Database for Annotation, Visualization and Integrated Discovery, these genes were divided into a number of subgroups associated with immunity, inflammation and cell signaling...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29516260/activation-of-satellite-glial-cells-in-trigeminal-ganglion-following-dental-injury-and-inflammation
#14
Haichao Liu, Lei Zhao, Wenzhen Gu, Qin Liu, Zhixiong Gao, Xiao Zhu, Zhi Wu, Hongwen He, Fang Huang, Wenguo Fan
Satellite glial cells (SGCs), a peripheral neuroglial cell, surround neurons and form a complete envelope around individual sensory neurons in the trigeminal ganglia (TG), which may be involved in modulating neurons in inflammation. The purpose of this study was to determine the effect of dental injury and inflammation on SGCs in the TG. Pulp exposure (PX) was performed on the first maxillary molar of 28 rats. The neurons innervating injured tooth in TG were labeled by the retrograde transport of fluoro-gold (FG)...
June 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29505090/astrocyte-elevated-gene-1-participates-in-the-production-of-pro-inflammatory-cytokines-in-dental-pulp-cells-via-nf-%C3%AE%C2%BAb-signalling-pathway
#15
H Wu, M He, R Yang, Y Zuo, Z Bian
AIM: To identify the role of astrocyte elevated gene-1 (AEG-1) and the mechanism underlying the inflammatory response in dental pulp cells. METHODOLOGY: Astrocyte elevated gene-1 expression was detected at different stages of pulpitis in a rat model using immunohistochemistry. RT-qPCR and Western blot were used to assess AEG-1 expression in human dental pulp cells stimulated by lipopolysaccharide (LPS). The LPS-induced expression of inflammatory cytokine genes was quantified by RT-qPCR in cells transfected with AEG-1 or negative control (NC) siRNA...
March 5, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29502358/mettl3-regulates-alternative-splicing-of-myd88-upon-the-lipopolysaccharide-induced-inflammatory-response-in-human-dental-pulp-cells
#16
Zhihui Feng, Qimeng Li, Runsha Meng, Baicheng Yi, Qiong Xu
Dental pulp inflammation is a widespread public health problem caused by oral bacterial infections and can progress to pulp necrosis and periapical diseases. N6-methyladenosine (m6A) is a prevalent epitranscriptomic modification in mRNA. Previous studies have demonstrated that m6A methylation plays important roles in cell differentiation, embryonic development and stress responses. However, whether m6A modification affects dental pulp inflammation remains unknown. To address this issue, we investigated the expression of m6A and N6-adenosine methyltransferase (METTL3, METTL14) as well as demethylases (FTO, ALKBH5) and found that the levels of m6A and METTL3 were up-regulated in human dental pulp cells (HDPCs) stimulated by lipopolysaccharide (LPS)...
May 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29486132/the-role-of-neuropilin-1-fyn-interaction-in-odontoblast-differentiation-of-dental-pulp-stem-cells
#17
Yihua Song, Peipei Cao, Zhifeng Gu, Jingwen Xiao, Min Lian, Dan Huang, Jing Xing, Ye Zhang, Xingmei Feng, Chenfei Wang
Abnormal odontoblast differentiation of dental pulp stem cells (DPSCs) caused by inflammation is closely related to the development of dental caries. Neuropilin-1 (NRP1) is one of the members of neuropilin family. It can combine with disparate ligands involved in regulating cell differentiation. FYN belongs to the protein-tyrosine kinase family, which has been implicated in the control of cell growth, and the effect can be further strengthened by inflammatory factors. In our studies, we verified that NRP1 can form complexes with FYN and have the correlation changes in odontoblast differentiation of DPSCs...
April 2018: Cellular Reprogramming
https://www.readbyqxmd.com/read/29483293/enterococcus-faecalis-demonstrates-pathogenicity-through-increased-attachment-in-an-ex-vivo-polymicrobial-pulpal-infection
#18
Wayne Nishio Ayre, Genevieve Melling, Camille Cuveillier, Madhan Natarajan, Jessica L Roberts, Lucy L Marsh, Christopher D Lynch, Jean-Yves Maillard, Stephen P Denyer, Alastair J Sloan
This study investigated the host response to a polymicrobial pulpal infection consisting of Streptococcus anginosus and Enterococcus faecalis , bacteria commonly implicated in dental abscesses and endodontic failure, using a validated ex vivo rat tooth model. Tooth slices were inoculated with planktonic cultures of S. anginosus or E. faecalis alone or in coculture at S. anginosus / E. faecalis ratios of 50:50 and 90:10. Attachment was semiquantified by measuring the area covered by fluorescently labeled bacteria...
May 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29482681/does-achievement-of-hemostasis-after-pulp-exposure-provide-an-accurate-assessment-of-pulp-inflammation
#19
Merve Mutluay, Volkan Arıkan, Saziye Sarı, Üçler Kısa
PURPOSE: The purpose of this study was to determine in primary molars with carious exposures whether hemostasis at the exposure site and pulp orifice reflected inflammatory status of the pulp at the canal orifice based on cytokine levels. METHODS: Forty mandibular primary molars with deep caries were included in the study. Teeth were divided into two groups: group A had teeth where hemostasis at the exposure site was achieved within five minutes, and group B had teeth where hemostasis at the exposure site could not be achieved within five minutes...
January 1, 2018: Pediatric Dentistry
https://www.readbyqxmd.com/read/29480617/autophagy-in-the-dentin-pulp-complex-against-inflammation
#20
L Zhang, Z Chen
The dentin-pulp complex is a highly specialized tissue for protecting the dental pulp. Odontoblasts are long-lived, hard-tissue-forming cells in the dentin-pulp complex and critically involved in inflammatory responses against invading pathogens. Autophagy is a highly conserved homeostasis mechanism of living cells under various stress conditions. Growing evidence in the literature addresses the role of autophagy in odontoblast differentiation and aging. This review summarizes the current knowledge about autophagy for the dentin-pulp complex in resisting inflammation...
March 2018: Oral Diseases
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