S Y Wang, S J Zhang, H F Meng, H Q Xu, Z X Guo, J F Yan, J L Gao, L N Niu, S L Wang, K Jiao
BACKGROUND: Oral submucous fibrosis (OSF) is a precancerous lesion characterized by fibrous tissue deposition, the incidence of which correlates positively with the frequency of betel nut chewing. Prolonged betel nut chewing can damage the integrity of the oral mucosal epithelium, leading to chronic inflammation and local immunological derangement. However, currently, the underlying cellular events driving fibrogenesis and dysfunction are incompletely understood, such that OSF has few treatment options with limited therapeutic effectiveness...
April 23, 2024: Stem Cell Research & Therapy