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https://www.readbyqxmd.com/read/28426090/oleuropein-down-regulated-il-1%C3%AE-induced-inflammation-and-oxidative-stress-in-human-synovial-fibroblast-cell-line-sw982
#1
Maria Luisa Castejón, Maria Ángeles Rosillo, Tatiana Montoya, Alejandro González-Benjumea, Jose Maria Fernández-Bolaños, Catalina Alarcón-de-la-Lastra
Rheumatoid arthritis (RA) is a chronic and systemic inflammatory autoimmune disease mainly characterized by aggressive hyperproliferation of synovial fibroblasts (SFs). It is accompained by a massive infiltration of inflammatory immune cells inducing progressive matrix degradation, destruction of cartilage and bone erosion through the production of inflammatory mediators. Oleuropein is the most prevalent phenolic component in olive leaves, seed, pulp and peel of unripe olives and is responsible for the characteristic bitter taste of unprocessed olives...
April 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28407420/dental-biofilm-infections-an-update
#2
REVIEW
Tove Larsen, Nils-Erik Fiehn
Teeth are colonized by oral bacteria from saliva containing more than 700 different bacterial species. If removed regularly, the dental biofilm mainly comprises oral streptococci and is regarded as resident microflora. But if left undisturbed, a complex biofilm containing up to 100 bacterial species at a site will build up and may eventually cause development of disease. Depending on local ecological factors, the composition of the dental biofilm may vary considerably. With access to excess carbohydrates, the dental biofilm will be dominated by mainly gram-positive carbohydrate-fermenting bacteria causing demineralization of teeth, dental caries, which may further lead to inflammation and necrosis in the pulp and periapical region, i...
April 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28394043/efficacy-of-stem-cells-on-periodontal-regeneration-systematic-review-of-pre-clinical-studies
#3
REVIEW
S A Tassi, N Z Sergio, M Y O Misawa, C C Villar
This systematic review aims to evaluate mesenchymal stem cells (MSC) periodontal regenerative potential in animal models. MEDLINE, EMBASE and LILACS databases were searched for quantitative pre-clinical controlled animal model studies that evaluated the effect of local administration of MSC on periodontal regeneration. The systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines. Twenty-two studies met the inclusion criteria. Periodontal defects were surgically created in all studies...
April 10, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28380697/graphene-oxide-enrichment-collagen-membranes-improves-dpscs-differentiation-and-controls-inflammation-occurrence
#4
Milena Radunovic, Marianna De Colli, Patrizia De Marco, Chiara Di Nisio, Antonella Fontana, Adriano Piattelli, Amelia Cataldi, Susi Zara
Collagen membranes are used in oral surgery for bone defects treatment acting as a barrier that does not allow the invasion of soft tissue into the growing bone. To improve biocompatibility collagen membranes were coated with graphene oxide (GO), a graphene derivative. The aim of this study was to investigate the biocompatibility of GO coated collagen membranes on human dental pulp stem cells (DPSCs) focusing on biomaterial cytotoxicity, ability to promote DPSCs differentiation process and to control inflammation event induction...
April 5, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28371334/the-risk-of-healing-complications-in-primary-teeth-with-concussion-and-subluxation-injury-a-retrospective-cohort-study
#5
Eva Lauridsen, Paul Blanche, Catherina Amaloo, Jens Ove Andreasen
BACKGROUND/AIM: Traumatic dental injuries (TDIs) in the primary dentition occur frequently. Long term complications may potentially cause damage to the permanent successor. The aim of this study was to report the risk of pulp necrosis (PN), pulp canal obliteration (PCO), repair related resorption (RRR), infection-related resorption (IRR), ankylosis-related resorption (ARR) and premature tooth loss (PTL) in primary teeth following concussion and subluxation injuries, and to identify possible risk factors for PN, PCO and PTL following subluxation...
March 28, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28368434/the-ghrelin-goat-system-regulates-obesity-induced-inflammation-in-male-mice
#6
Rebecca E Harvey, Victor G Howard, Moyra B Lemus, Tara Jois, Zane B Andrews, Mark W Sleeman
Ghrelin plays a key role in appetite, energy homeostasis and glucose regulation. Recent evidence suggests ghrelin suppresses inflammation in obesity, however whether this is modulated by the acylated and/or des-acylated peptide is unclear. We used mice deficient in acylated ghrelin (GOAT KO), wildtype littermates (WT) and C57BL/6 mice to examine the endogenous and exogenous effects of acyl and des-acyl ghrelin on inflammatory profiles under non-obese and obese conditions. We demonstrate that in the spleen, both ghrelin and Ghrelin O-Acyl Transferase (GOAT) are localized primarily in the red pulp...
March 29, 2017: Endocrinology
https://www.readbyqxmd.com/read/28368079/the-effect-of-extracellular-acidosis-on-the-behaviour-of-mesenchymal-stem-cells-in-vitro
#7
A Massa, F Perut, T Chano, A Woloszyk, T A Mitsiadis, S Avnet, N Baldini
The stem cell fraction of a cell population is finely tuned by stimuli from the external microenvironment. Among these stimuli, a decrease of extracellular pH (pHe) may occur in a variety of physiological and pathological conditions, including hypoxia and inflammation. In this study, by using bone marrow stem cells and dental pulp stem cells, we provided evidence that extracellular acidosis endows the maintenance of stemness in mesenchymal cells. Indeed, continuous exposure for 21 d to low pHe (6.5-6.8) conditions impaired the osteogenic differentiation of both cell types...
April 3, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/28365680/pro-inflammatory-cytokine-tnf-%C3%AE-attenuates-bmp9-induced-osteo-odontoblastic-differentiation-of-the-stem-cells-of-dental-apical-papilla-scaps
#8
Feilong Wang, Ying Jiang, Xia Huang, Qiao Liu, Yan Zhang, Wenping Luo, Fugui Zhang, Pengfei Zhou, Juhong Lin, Hongmei Zhang
BACKGROUND/AIMS: Periapical periodontitis is a common oral disease caused by bacterial invasion of the tooth pulp, which usually leads to local release of pro-inflammatory cytokines and osteolytic lesion. This study is intended to examine the effect of TNF-α on BMP9-induced osteogenic differentiation of the stem cells of dental apical papilla (SCAPs). METHODS: Rat model of periapical periodontitis was established. TNF-α expression was assessed. Osteogenic markers and ectopic bone formation in iSCAPs were analyzed upon BMP9 and TNF-α treatment...
March 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28349653/the-risk-of-healing-complications-in-primary-teeth-with-intrusive-luxation-a-retrospective-cohort-study
#9
Eva Lauridsen, Paul Blanche, Nadia Yousaf, Jens Ove Andreasen
BACKGROUND/AIMS: Intrusive luxation is a frequent injury in the primary dentition. Complications such as ankylosis or pulp necrosis and infection with periapical inflammation may affect the developing permanent tooth if not diagnosed and treated in time. The aim of this study was to report the risk of pulp necrosis (PN), pulp canal obliteration (PCO), infection-related resorption (IRR), ankylosis-related resorption (ARR) and premature tooth loss (PTL) in primary teeth following intrusive luxation, and to identify possible risk factors for PN and PTL...
March 28, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28348613/histopathological-changes-in-dental-pulp-of-rats-following-radiotherapy
#10
Zahra Sadat Madani, Soheil Azarakhsh, Pouyan Amini Shakib, Masoomeh Karimi
BACKGROUND: Radiotherapy is one of the oral and pharyngeal cancer treatment methods that can cause damage to the tissues in the radiation area; the purpose of this study is to evaluate the effects of radiotherapy on dental pulp tissue in rats. MATERIALS AND METHODS: In this interventional, experimental double-blind study, 30 rats were studied in three groups (n = 10 each). The first group received 12 gray (Gy), the second group received 18 Gy in one session, and the third group was not exposed to radiation (control group)...
January 2017: Dental Research Journal
https://www.readbyqxmd.com/read/28332168/pulp-bleeding-color-is-an-indicator-of-clinical-and-histohematologic-status-of-primary-teeth
#11
Naser Asl Aaminabadi, Marziyeh Parto, Parya Emamverdizadeh, Zahra Jamali, Sajjad Shirazi
OBJECTIVES: This study was carried out to investigate whether the changes in hematologic characteristic and color of pulpal bleeding is associated with clinical and histologic status of the pulp in primary teeth. MATERIALS AND METHODS: A total of 211 primary molars in 103 patients, 3-6 years old, were treated. One hundred eight teeth had pulpectomy, 57 teeth had pulpotomy after pulp exposure during caries excavation, and 46 teeth had pulpotomy after accidental pulp exposure in sound dentin...
March 23, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28318161/-clinical-comparative-study-on-the-efficacy-of-periodontal-endodontic-therapy-and-periodontal-treatment-alone-for-advanced-periodontitis
#12
RANDOMIZED CONTROLLED TRIAL
Tan Baochun, Xiao Jianping, Yan Fuhua, Huan Hong
OBJECTIVE: This study aimed to explore the period of endodontic treatment and the effects of periodontal-endodontic treatment for advanced periodontitis. METHODS: A total of 180 patients with advanced periodontitis participated in this clinical multicenter study. The respondents were randomly divided into an endodontic combined treatment (experimental) group and a periodontal treatment alone (control) group; each group consisted of 90 teeth. The control group received periodontal therapy only...
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28257892/role-of-%C3%AE-1-3-galactosyltransferase-2-in-trigeminal-neuronal-sensitization-induced-by-peripheral-inflammation
#13
Yiheng Lv, Lili Ren, Yunjie Fu, Keqiang Huang, Jing Bi
Glycosyltransferases are enzymes that catalyze the formation of a variety of glycoconjugates. Glycoconjugates play important roles in the nervous system. β-1,3-Galactosyltransferase 2 (B3galt2) belongs to the family of β-1,3-galactosyltransferase, which is one of the major types of glycosyltransferases. Dental pulp inflammation may cause neurophysiological alterations in the trigeminal ganglion (TG), and serve as a good model for investigating the peripheral inflammation and trigeminal neuronal sensitization...
May 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/28253184/idiopathic-external-apical-root-resorption-clinical-report-of-2-cases
#14
Ricardo Machado, Graziela Bianchi Leoni, Pedro Yarid, Antonio Miranda Cruz-Filho, Manoel Damião Sousa-Neto
External root resorptions are characterized by progressive destruction of hard tissue due to clastic activity. This article reports 2 cases that involved the nonsurgical treatment of mandibular molars with idiopathic external root resorption. In the first case, clinical and radiographic examination showed irreversible inflammation of the pulp tissue and resorption of the distal root. Chronic inflammatory infiltrate and necrosis were identified by histopathologic examination of the pulp tissue. In the second case, inadequate endodontic treatment and a resorptive process were observed in the mesial and distal roots...
March 2017: General Dentistry
https://www.readbyqxmd.com/read/28198096/treated-dentin-matrix-paste-as-a-novel-pulp-capping-agent-for-dentin-regeneration
#15
Jinlong Chen, Caiyun Cui, Xiangchen Qiao, Bo Yang, Mei Yu, Weihua Guo, Weidong Tian
Regenerating dentin and preserving pulp vitality are the two key targets for the treatment of dental pulp exposure. Calcium hydroxide (CH), the widely used capping agent, may induce potential tunnel defect in reparative dentin and cause inflammation or even necrosis in pulp tissues. This study aimed to produce a novel pulp capping agent with better bioactivities. Treated dentin matrix (TDM) paste (TDMP) was fabricated consisting of TDM powder and aqueous TDM extract. The chemical and biological characteristics of TDMP were investigated, and its effect on the odontogenic differentiation of dental pulp stem cells explored at gene and protein level; the therapeutic effect for pulp exposure in miniature swine was further verified...
February 15, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28190588/survival-of-the-apical-papilla-and-its-resident-stem-cells-in-a-case-of-advanced-pulpal-necrosis-and-apical-periodontitis
#16
Vanessa Chrepa, Brandon Pitcher, Michael A Henry, Anibal Diogenes
INTRODUCTION: Apical papilla represents a source of an enriched mesenchymal stem cell (MSC) population (stem cells of the apical papilla [SCAPs]) that modulates root development and may participate in regenerative endodontic procedures in immature teeth with pulp necrosis. The characteristics and phenotype of this tissue in the presence of inflammation are largely unknown. The purpose of this study was to characterize a human apical papilla sample that was isolated from an immature tooth with pulp necrosis and apical periodontitis...
April 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28190584/the-effects-of-m1-and-m2-macrophages-on-odontogenic-differentiation-of-human-dental-pulp-cells
#17
Hee Chul Park, Hongxuan Quan, Tingting Zhu, Yongjoon Kim, Bongju Kim, Hyeong-Cheol Yang
INTRODUCTION: M1 (classically activated) and M2 (alternatively activated) macrophages are known to play primary roles in inflammation and tissue regeneration. To investigate the role of macrophages in dentin regeneration, this study examined the effects of M1 and M2 macrophages on the odontogenic/osteogenic differentiation of human dental pulp cells (HDPCs) using the conditioned media (CM) of the activated human monocyte cell line THP-1. METHODS: M1 and M2 macrophages were induced by lipopolysaccharide/interferon-γ and interleukin-4, respectively, and the phenotypes were confirmed by flow cytometry...
April 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28138240/plant-derived-pectin-nanocoatings-to-prevent-inflammatory-cellular-response-of-osteoblasts-following-porphyromonas-gingivalis-infection
#18
Anna Meresta, Justyna Folkert, Timo Gaber, Korneliusz Miksch, Frank Buttgereit, Jacqueline Detert, Nicole Pischon, Katarzyna Gurzawska
BACKGROUND: Bioengineered plant-derived Rhamnogalacturonan-Is (RG-Is) from pectins are potential candidates for surface nanocoating of medical devices. It has recently been reported that RG-I nanocoatings may prevent bacterial infection and improve the biocompatibility of implants. The aim of the study was to evaluate in vitro impact of bioengineered RG-I nanocoatings on osteogenic capacity and proinflammatory cytokine response of murine osteoblasts following Porphyromonas gingivalis infection...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28132712/the-triple-functions-of-d2-silencing-in-treatment-of-periapical-disease
#19
Jie Pan, Jue Wang, Liang Hao, Guochun Zhu, Diep N Nguyen, Qian Li, Yuehua Liu, Zhihe Zhao, Yi-Ping Li, Wei Chen
INTRODUCTION: Dental caries is the most widespread chronic infectious disease. Inflammation in pulp tissues caused by dental caries will lead to periapical granulomas, bone erosion, loss of the tooth, and severe pain. Despite numerous efforts in recent studies to develop effective treatments for dental caries, the need for a potent therapy is still urgent. METHODS: In this study, we applied a gene-based therapy approach by administering recombinant adeno-associated virus (AAV)-mediated Atp6v0d2 (d2) RNA interference knockdown of d2 gene expression to prevent periapical bone loss and suppress periapical inflammation simultaneously...
February 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28125136/why-not-to-treat-the-tooth-canal-to-solve-external-root-resorptions-here-are-the-principles
#20
Alberto Consolaro, Graziella Bittencourt
This paper aims at exposing the foundations or reasons why, in cases of external tooth resorption, including those of orthodontic origin, one should not perform a root canal to treat it. That should be done only to teeth with contamination or pulp necrosis, to remove the periapical inflammation induced by microbial products. When facing cases of external tooth resorption, one's conduct must always respect the following sequence of steps: first of all, identifying the cause accurately; then, planning the therapeutic approach and, finally, adopting the conducts in a very well-founded way...
November 2016: Dental Press Journal of Orthodontics
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