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https://www.readbyqxmd.com/read/27914008/igf1r-dental-pulp-stem-cells-enhanced-neuroplasticity-in-hypoxia-ischemia-model
#1
Hsiao-Yu Chiu, Chen-Huan Lin, Chung Y Hsu, John Yu, Chia-Hung Hsieh, Woei-Cherng Shyu
Until now, the surface markers of multipotent mesenchymal stem cells (MSCs) had not been fully identified. Here, we found that the IGF1 receptor (IGF1R), regarded as a pluripotent marker of embryonic stem cells (ESCs), was also expressed in human dental pulp derived-mesenchymal stem cells (hDSCs), which displayed a potential for both self-renewal and multipotency. hDSC-secreted IGF1 interacted with IGF1R through an autocrine signaling pathway to maintain this self-renewal and proliferation potential. Stereotaxic implantation of immunosorted IGF1R(+) hDSCs in rats with neonatal hypoxia-ischemia (NHI) promoted neuroplasticity, improving the neurological outcome by increasing expression of the anti-apoptotic protein Bcl-2, which enhanced both neurogenesis and angiogenesis...
December 2, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27898727/biological-markers-for-pulpal-inflammation-a-systematic-review
#2
Dan-Krister Rechenberg, Johnah C Galicia, Ove A Peters
BACKGROUND AND OBJECTIVE: Pulpitis is mainly caused by an opportunistic infection of the pulp space with commensal oral microorganisms. Depending on the state of inflammation, different treatment regimes are currently advocated. Predictable vital pulp therapy depends on accurate determination of the pulpal status that will allow repair to occur. The role of several players of the host response in pulpitis is well documented: cytokines, proteases, inflammatory mediators, growth factors, antimicrobial peptides and others contribute to pulpal defense mechanisms; these factors may serve as biomarkers that indicate the status of the pulp...
2016: PloS One
https://www.readbyqxmd.com/read/27866710/pulpal-tissue-inflammatory-reactions-after-experimental-pulpal-exposure-in-mice
#3
Ying He, Youhua Gan, Jiajian Lu, Qiong Feng, Haiyan Wang, Hongbing Guan, Qianzhou Jiang
INTRODUCTION: The purpose of this study was to establish a stable experimental mice pulpal inflammatory model and to evaluate inflammatory reactions of pulpal tissue after pulpal exposure. METHODS: Pulpal inflammation was induced in 80 C57BL/6 mice by occlusal exposure of the pulp of the maxillary first molar. The mice were sacrificed randomly at 0, 1, 6, 12, 24, 48, and 72 hours after pulpal exposure. Mice without pulpal exposure served as controls. Maxillary teeth were obtained and prepared for histologic analyses and real-time polymerase chain reaction analyses...
November 17, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27825676/expression-of-hypoxia-induced-semaphorin-7a-correlates-with-the-severity-of-inflammation-and-osteoclastogenesis-in-experimentally-induced-periapical-lesions
#4
Miao He, Zhuan Bian
OBJECTIVE: While hypoxia and inflammation are intimately linked, the effects of inflammatory hypoxia on the pathogenesis of periapical lesions remain largely unknown. The aim of this study was to examine hypoxia during the progression of experimentally induced rat periapical lesions, and to derive correlations between hypoxia-induced Semaphorin 7A (Sema7a) expression, severity of inflammation, and osteoclastogenesis in the lesions. DESIGN: Periapical lesions were developed after mandibular first molar pulp exposure in forty Sprague-Dawley rats...
October 29, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27812622/inflammatory-response-of-human-dental-pulp-to-at-home-and-in-office-tooth-bleaching
#5
Maysa Magalhães Vaz, Lawrence Gonzaga Lopes, Paula Carvalho Cardoso, João Batista de Souza, Aline Carvalho Batista, Nádia Lago Costa, Érica Miranda Torres, Carlos Estrela
Objective: This study evaluated the inflammatory responses of human dental pulp after the use of two bleaching techniques. Material and Methods: Pulp samples were collected from human third molars extracted for orthodontic reasons and divided into three groups: control - no tooth bleaching (CG) (n=7); at-home bleaching with 15% carbamide peroxide (AH) (n = 10), and in-office bleaching with 38% hydrogen peroxide (IO) (n=12). Pulps were removed and stained with hematoxylin-eosin for microscopic analysis of inflammation intensity, collagen degradation, and pulp tissue organization...
September 2016: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/27790263/the-effect-of-mineral-trioxide-aggregate-mixed-with-chlorhexidine-as-direct-pulp-capping-agent-in-dogs-teeth-a-histologic-study
#6
Hamed Manochehrifar, Masoud Parirokh, Sina Kakooei, Mohammad Mehdi Oloomi, Saeed Asgary, Mohammad Jafar Eghbal, Fatemeh Mashhadi Abbas
INTRODUCTION: The aim of the present investigation was to compare the efficacy of mineral trioxide aggregate (MTA) and 0.2% chlorhexidine (CHX) mixture to pure MTA, as a pulp capping material. METHODS AND MATERIALS: The pulp of 24 lateral incisors and canines from four dogs were exposed and capped either with MTA or MTA+0.2% CHX. After 2 months the animals were sacrificed and the teeth were prepared for histological evaluation in terms of calcified bridge formation, the degree of inflammation and presence of necrosis...
2016: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/27767114/review-suggests-direct-pulp-capping-with-mta-more-effective-than-calcium-hydroxide
#7
Lakshmi Rasaratnam
Data sourcesPubMed, the Cochrane Library, Embase, and the Web of Knowledge.Study selectionRandomised controlled trials (RCTs) or retrospective non-randomised trials (RNTs) of direct pulp capping in patients comparing mineral trioxide aggregate (MTA) with calcium hydroxide (CH) were considered.Data extraction and synthesisTwo reviewers independently abstracted data. Risk of bias for the RCTs was assessed using the Cochrane risk of bias tool and RNTs were assessed according to the methodological index for non-randomised studies...
September 2016: Evidence-based Dentistry
https://www.readbyqxmd.com/read/27761672/histologic-tissue-response-to-furcation-perforation-repair-using-mineral-trioxide-aggregate-or-dental-pulp-stem-cells-loaded-onto-treated-dentin-matrix-or-tricalcium-phosphate
#8
H Bakhtiar, H Mirzaei, M R Bagheri, N Fani, F Mashhadiabbas, M Baghaban Eslaminejad, D Sharifi, M H Nekoofar, Pmh Dummer
OBJECTIVES: The aim of this study is to compare the effect of treated dentine matrix (TDM) and tricalcium phosphate (TCP) scaffolds on odontogenic differentiation and mineralization of dental pulp stem cells (DPSCs) in furcation perforations created in the pulp chamber floor of premolar teeth in dogs. MATERIAL AND METHODS: DPSCs were isolated and cultured from the dental pulp of the maxillary left second and third premolars of dogs. The DPSCs were loaded on TCP (SC+TCP) and TDM (SC+TDM) scaffolds and inserted into intentionally perforated pulp chamber floors of premolars in dogs; six teeth were used for each group...
October 20, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27752174/-impact-of-different-degree-pulpitis-on-cell-proliferation-and-osteoblastic-differentiation-of-dental-pulp-stem-cell-in-beagle-immature-premolars
#9
L Ling, Y M Zhao, L H Ge
OBJECTIVE: To compare the proliferation and osteoblastic differentiation of dental pulp stem cell (DPSC) isolated from normal and inflamed pulps of different degrees in Beagle immature premolars, and provide evidence for the use of inflammatory DPSC (IDPSC). METHODS: This study evaluated 14 Beagle's young premolars (21 roots). In the experiment group, irreversible pulpitis was induced by pulp exposure and the inflamed pulps were extracted 2 weeks and 6 weeks after the pulp chamber opening...
October 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27744048/pulp-and-apical-tissue-response-to-deep-caries-in-immature-teeth-a-histologic-and-histobacteriologic-study
#10
Domenico Ricucci, José F Siqueira, Simona Loghin, Louis M Lin
: Descriptions of the pathologic changes in the pulp and associated apical structures of human immature teeth in response to deep caries are lacking in the literature. OBJECTIVES: This article describes the histologic events associated with the radicular pulp and the apical tissues of human immature teeth following pulp inflammation and necrosis. METHODS: Twelve immature teeth with destructive caries lesions were obtained from 8 patients. Two intact immature teeth served as controls...
October 12, 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/27726970/immunomodulatory-anti-inflammatory-effect-of-zoe-based-dental-materials
#11
Jung-Hwan Lee, Hae-Hyoung Lee, Hae-Won Kim, Je-Wook Yu, Kyoung-Nam Kim, Kwang-Mahn Kim
OBJECTIVE: The study assessed the cytotoxicity and immunomodulatory/anti-inflammatory effect of extract from zinc oxide-eugenol (ZOE)-based dental materials during setting using immortalized human dental pulp stem cells (IHDPSCs) and mouse bone marrow monocytes (IMBMMs), and identified the responsible extract component. METHODS: In accord with the ISO 10993-12, we extracted a mixture of ZOE cement and sealer after a specified time. The extract was analyzed by two types of mass spectrometry (ICP-MS and GC-MS)...
October 7, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27716214/administration-of-amd3100-in-endotoxemia-is-associated-with-pro-inflammatory-pro-oxidative-and-pro-apoptotic-effects-in-vivo
#12
Semjon Seemann, Amelie Lupp
BACKGROUND: Chemokine receptor 4 (CXCR4) is a multifunctional G protein-coupled receptor that is activated by its natural ligand, C-X-C motif chemokine 12 (CXCL12). As a likely member of the lipopolysaccharide (LPS)-sensing complex, CXCR4 is involved in pro-inflammatory cytokine production and exhibits substantial chemo-attractive activity for various inflammatory cells. Here, we aimed to characterize the effects of CXCR4 blockade in systemic inflammation and to evaluate its impact on organ function...
October 3, 2016: Journal of Biomedical Science
https://www.readbyqxmd.com/read/27687716/changes-in-nitric-oxide-synthase-isoforms-in-the-trigeminal-ganglion-of-rat-following-chronic-tooth-pulp-inflammation
#13
Qin Liu, Zhixiong Gao, Xiao Zhu, Zhi Wu, Dongpei Li, Hongwen He, Fang Huang, Wenguo Fan
Nitric oxide (NO) possibly plays an important role in the events resulting in hyperalgesia. NO synthase (NOS) is a key enzyme in the production of NO. Changes in NOS expression in primary sensory neurons may be involved in the persistent sensory abnormalities that can be induced by inflammation. To assess the possible roles of NOS in trigeminal sensory system, we studied changes in the expression of NOS isoforms in the trigeminal ganglion (TG) following chronic inflammation after pulp exposure (PX) in rats...
October 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27687583/endodontic-repair-in-immature-dogs-teeth-with-apical-periodontitis-blood-clot-versus-plasma-rich-in-growth-factors-scaffold
#14
Omid Dianat, Fatemeh Mashhadi Abas, Payam Paymanpour, Mohammad Jafar Eghbal, Sahar Haddadpour, Nazanin Bahrololumi
BACKGROUND/AIM: Different types of scaffolds have been suggested for endodontic repair procedures. The aim of this study was to compare the outcome of procedures using blood clot versus plasma rich in growth factors (PRGF) scaffold in immature teeth with apical periodontitis in dogs. MATERIALS AND METHODS: In this in vivo animal study, 20 teeth (30 canals) with open apices were divided into two groups (n = 12): (1) blood clot and (2) PRGF. Two positive and negative control groups were also selected randomly...
September 30, 2016: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/27679980/pannexin3-inhibits-tnf-%C3%AE-induced-inflammatory-response-by-suppressing-nf-%C3%AE%C2%BAb-signalling-pathway-in-human-dental-pulp-cells
#15
Fangfang Song, Hualing Sun, Yake Wang, Hongye Yang, Liyuan Huang, Dongjie Fu, Jing Gan, Cui Huang
Human dental pulp cells (HDPCs) play a crucial role in dental pulp inflammation. Pannexin 3 (Panx3), a member of Panxs (Pannexins), has been recently found to be involved in inflammation. However, the mechanism of Panx3 in human dental pulp inflammation remains unclear. In this study, the role of Panx3 in inflammatory response was firstly explored, and its potential mechanism was proposed. Immunohistochemical staining showed that Panx3 levels were diminished in inflamed human and rat dental pulp tissues. In vitro, Panx3 expression was significantly down-regulated in HDPCs following a TNF-α challenge in a concentration-dependent way, which reached the lowest level at 10 ng/ml of TNF-α...
September 29, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27650043/vegfr-2-reduces-while-combined-vegfr-2-and-3-signaling-increases-inflammation-in-apical-periodontitis
#16
Anca Virtej, Panagiota Papadakou, Hajime Sasaki, Athanasia Bletsa, Ellen Berggreen
BACKGROUND: In apical periodontitis, oral pathogens provoke an inflammatory response in the apical area that induces bone resorptive lesions. In inflammation, angio- and lymphangiogenesis take place. Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are key players in these processes and are expressed in immune cells and endothelial cells in the lesions. OBJECTIVE: We aimed at testing the role of VEGFR-2 and -3 in periapical lesion development and investigated their role in lymphangiogenesis in the draining lymph nodes...
2016: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/27630966/biodentine-pulpotomy-in-mature-permanent-molar-a-case-report
#17
Harleen Kaur Soni
Irreversible pulpitis is the most common reason for endodontic treatment in primary and permanent teeth. Root canal therapy and extraction are the two viable and most documented treatment options for the same. Studies with regards to management of mature permanent teeth with carious exposure and treatment with vital pulp therapies such as adult permanent tooth pulpotomy are scarce. However, permanent tooth pulpotomy with the new calcium-silicate based cements (Mineral Trioxide Aggregate and Biodentine) can help preserve the tooth pulp vitality and promote healing and repair foregoing the more invasive root canal therapy procedure...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27630497/evaluation-of-pulpal-response-of-deciduous-teeth-after-direct-pulp-capping-with-bioactive-glass-and-mineral-trioxide-aggregate
#18
Roza Haghgoo, Motahare Ahmadvand
AIM: The aim of this study was to evaluate the pulpal response of primary teeth after direct pulp capping (DPC) with two biocompatible materials namely mineral trioxide aggregate (MTA) and bioactive glass (BAG). SETTINGS AND DESIGN: This study was a randomized clinical trial. MATERIALS AND METHODS: A total of 22 healthy primary canine teeth scheduled for extraction for orthodontic reasons were selected. The teeth were divided into two groups of 11 and underwent DPC...
July 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27614116/the-effect-of-dental-bleaching-on-pulpal-tissue-response-in-a-diabetic-animal-model
#19
L T A Cintra, L L Ferreira, F Benetti, A A Gastélum, J E Gomes-Filho, E Ervolino, A L F Briso
AIM: To evaluate pulpal tissue response after dental bleaching in normal and alloxan-induced diabetic rats. METHODOLOGY: Twenty-eight rats were divided into two groups of normoglycaemic and diabetic rats (n = 14). Diabetes mellitus (DM) was induced with alloxan. After DM confirmation, all rats were anaesthetized and dental bleaching was performed with 35% hydrogen peroxide (H2 O2 ) on the right maxillary molars for 30 min. Left molars were used as controls. Bleaching resulted in four hemimaxillae groups: normoglycaemic (N), N-bleached (NBle), diabetic (D) and D-bleached (DBle)...
September 10, 2016: International Endodontic Journal
https://www.readbyqxmd.com/read/27605996/the-effect-of-intrusive-orthodontic-force-on-dental-pulp-of-adults-versus-adolescents
#20
Mostafa Abtahi, Neda Eslami, Reza Zare Mahmoud Abadi, Saber Pooria Rezaei
BACKGROUND: There is no conclusive evidence on the effect of orthodontic force application on dental pulp tissue. The aim of this study was to compare early and delayed histological effects of intrusive forces on dental pulp of adolescents and adults. MATERIALS AND METHODS: Patients referred to the Department of Orthodontics of Mashhad University of Medical Sciences participated in this study. They were assigned to adult (25-32-year-old) and adolescent (13-18-year-old) Groups...
July 2016: Dental Research Journal
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