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https://www.readbyqxmd.com/read/29329593/targeting-ectodysplasin-promotor-by-crispr-dcas9-effector-effectively-induces-the-reprogramming-of-human-bone-marrow-derived-mesenchymal-stem-cells-into-sweat-gland-like-cells
#1
Sujing Sun, Jun Xiao, Jiahui Huo, Zhijun Geng, Kui Ma, Xiaoyan Sun, Xiaobing Fu
BACKGROUND: Patients with a deep burn injury are characterized by losing the function of perspiration and being unable to regenerate the sweat glands. Because of their easy accession, multipotency, and lower immunogenicity, bone marrow-derived mesenchymal stem cells (BM-MSCs) represent as an ideal biological source for cell therapy. The aim of this study was to identify whether targeting the promotor of ectodysplasin (EDA) by CRISPR/dCas9-effector (dCas9-E) could induce the BM-MSCs to differentiate into sweat gland-like cells (SGCs)...
January 12, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29249879/a-spectrophotometric-analysis-of-extraoral-aging-conditions-on-the-color-stability-of-maxillofacial-silicone
#2
Siddharth Mehta, D B Nandeeshwar
Context: Surveys have reported color fading as the most frequent reasons patients given for disliking their prostheses. Aim: The aim of the study is to compare the color variation between two maxillofacial silicone elastomers after subjecting them to extraoral aging conditions. Subjects and Methods: A total of 80 samples were made from M511 Maxillofacial Rubber (Part A: Part B = 10:1) and Z004 Platinum Silicone Rubber (Part A: Part B = 1:1) and divided into two main Groups A and B (40 each)...
October 2017: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/29233679/graphene-paper-supported-mos2-nanocrystals-monolayer-with-cu-submicron-buds-high-performance-flexible-platform-for-sensing-in-sweat
#3
Zhengyun Wang, Shuang Dong, Mengxi Gui, Muhammad Asif, Wei Wang, Feng Wang, Hongfang Liu
Flexible sweat biosensors are of considerable current interest for the development of wearable smart miniature devices. In this work, we report a novel type of flexible and electrochemical sweat platform fabricated by depositing Cu submicron buds on freestanding graphene paper (GP) carrying MoS2 nanocrystals monolayer for bio-functional detection of glucose and lactate. Quantitative analysis of glucose and lactate was carried out by using amperometric i-t method. Linear ranges were obtained between 5 and 1775 μM for glucose and 0...
December 9, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/29171366/-palmar-and-axillary-hyperhidrosis-in-children-endoscopic-thoracic-sympathectomy-using-clips-for-an-underestimated-problem
#4
S M Hermelijn, I H Boersma, M H Dekker, S van Duin, J M Schnater
BACKGROUND: Palmar and axillary hyperhidrosis are defined as perspiration exceeding the body's 'normal' physiological need for thermal regulation. This condition affects about 1% of adolescents and children and may lead to psychosocial problems and poor school performance. CASE DESCRIPTION: We carried out an endoscopic thoracic sympathectomy (ETS) with clips in a 14-year-old girl and a 16-year-old girl who suffered from debilitating palmar and axillary hyperhidrosis...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29168215/non-corticosteroid-adherence-and-itch-severity-influence-perception-of-itch-in-atopic-dermatitis
#5
Satoshi Takeuchi, Junna Oba, Hitokazu Esaki, Masutaka Furue
Topical corticosteroid phobia is an important problem in the treatment of atopic dermatitis as it can affect the ability to control disease severity and itch by reducing treatment adherence. Topical corticosteroid phobia often ends up even non-corticosteroid adherence. As such, non-corticosteroid adherence, disease severity and itch are likely to be associated with each other, but their relationship has yet to be thoroughly investigated. Thus, the purpose of this study is to investigate it in atopic dermatitis...
November 23, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29128285/prolonged-and-localized-sweat-stimulation-by-iontophoretic-delivery-of-the-slowly-metabolized-cholinergic-agent-carbachol
#6
Phillip Simmers, S Kevin Li, Gerald Kasting, Jason Heikenfeld
BACKGROUND: Continuous non-invasive sampling and sensing of multiple classes of analytes could revolutionize medical diagnostics and wearable technologies, but also remains highly elusive because of the many confounding factors for candidate biofluids such as interstitial fluid, tears, saliva, and sweat. Eccrine sweat biosensing has seen a recent surge in demonstrations of wearable sampling and sensing devices. However, for subjects at rest, access to eccrine sweat is highly limited and unpredictable compared to saliva and tears...
November 8, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29064607/hypothalamic-pituitary-thyroid-hpt-axis-functioning-in-anxiety-disorders-a-systematic-review
#7
REVIEW
Susanne Fischer, Ulrike Ehlert
Depression has repeatedly been linked to subclinical hypothyroidism, and thyroid hormones have successfully been used to augment antidepressant treatment. By contrast, the extent of thyroid dysfunction in anxiety disorders remains less clear. This is surprising, given that anxiety-related symptoms (e.g., nervousness, palpitations, increased perspiration) are highly prevalent in hyperthyroidism. The present study was undertaken to synthesize the literature on hypothalamic-pituitary-thyroid (HPT) axis functioning in anxiety disorders...
October 24, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29060733/development-of-a-thermal-associated-pain-index-score-using-infrared-thermography-for-objective-pain-assessment
#8
M Czaplik, N Hochhausen, H Dohmeier, C Barbosa Pereira, R Rossaint
Without any doubt, research in biomedical engineering and anesthesiology achieved diverse ground-breaking successes for the sake of patient safety and for optimization of medical treatment in the last decades. Particularly anesthesia has become increasingly comfortable and safer due to new monitoring devices and further techniques. However, assessment of pain still relies on self-reporting of the patient using a Numeric Rating Scale ranging from 0 to 10. Obviously, this method suffers from severe restraints when unconscious, anesthetized or uncooperative subjects or children are involved as patients...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29042582/portable-biosensor-for-monitoring-cortisol-in-low-volume-perspired-human-sweat
#9
David Kinnamon, Ramesh Ghanta, Kai-Chun Lin, Sriram Muthukumar, Shalini Prasad
A non-faradaic label-free cortisol biosensor was demonstrated using MoS2 nanosheets integrated into a nanoporous flexible electrode system. Low volume (1-5 μL) sensing was achieved through use of a novel sensor stack design comprised of vertically aligned metal electrodes confining semi-conductive MoS2 nanosheets. The MoS2 nanosheets were surface functionalized with cortisol antibodies towards developing an affinity biosensor specific to the physiological relevant range of cortisol (8.16 to 141.7 ng/mL) in perspired human sweat...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923015/transcriptome-analysis-of-pseudostellaria-heterophylla-in-response-to-the-infection-of-pathogenic-fusarium-oxysporum
#10
Xianjin Qin, Hongmiao Wu, Jun Chen, Linkun Wu, Sheng Lin, Muhammad Umar Khan, Mohammad Reza Boorboori, Wenxiong Lin
BACKGROUND: Pseudostellaria heterophylla (P. heterophylla), a herbaceous perennial, belongs to Caryophyllaceae family and is one of the Chinese herbal medicine with high pharmacodynamic value. It can be used to treat the spleen deficiency, anorexia, weakness after illness and spontaneous perspiration symptoms. Our previous study found that consecutive monoculture of Pseudostellaria heterophylla could lead to the deterioration of the rhizosphere microenvironment. The specialized forms of pathogenic fungus Fusarium oxysporum f...
September 18, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28858812/a-thermally-powered-isfet-array-for-on-body-ph-measurement
#11
Matthew Douthwaite, Ermis Koutsos, David C Yates, Paul D Mitcheson, Pantelis Georgiou
Recent advances in electronics and electrochemical sensors have led to an emerging class of next generation wearables, detecting analytes in biofluids such as perspiration. Most of these devices utilize ion-selective electrodes (ISEs) as a detection method; however, ion-sensitive field-effect transistors (ISFETs) offer a solution with improved integration and a low power consumption. This work presents a wearable, thermoelectrically powered system composed of an application-specific integrated circuit (ASIC), two commercial power management integrated circuits and a network of commercial thermoelectric generators (TEGs)...
August 24, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28803369/volume-balance-and-intradialytic-ultrafiltration-rate-in-the-hemodialysis-patient
#12
REVIEW
Jason A Chou, Kamyar Kalantar-Zadeh
PURPOSE OF REVIEW: Volume management in hemodialysis patients is often challenging. Assessing volume status and deciding how much fluid to remove during hemodialysis, the so-called ultrafiltration rate (UFR), has remained a conundrum. RECENT FINDINGS: To date there is no objective assessment tool to determine the needed UFR during each hemodialysis session. Higher volume overload or higher UFR is associated with poor outcomes including worse mortality and unfavorable clinical outcomes...
October 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28795753/single-wearable-sensing-energy-device-based-on-photoelectric-biofuel-cells-for-simultaneous-analysis-of-perspiration-and-illuminance
#13
You Yu, Junfeng Zhai, Yong Xia, Shaojun Dong
Wearable electronics are essential for the construction of epidermal energy supply and portable healthcare devices. Herein, a self-powered wearable electronic device based on a photoelectric biofuel cell has been introduced for the first time to simultaneously detect the perspiration lactate and monitor the ambient illuminance depending on independent parameters. The functions of harvesting energy, detection of body function and monitoring of ambient have been merged into a single wireless sensor. This novel design may provide a wide range of smart and exciting wearable electronics...
August 24, 2017: Nanoscale
https://www.readbyqxmd.com/read/28782691/first-case-of-autonomic-dysreflexia-following-elective-lower-thoracic-spinal-cord-transection-in-a-spina-bifida-adult
#14
Juanita Garces, Mansour Mathkour, Tyler Scullen, Lora Kahn, Erin Biro, Alex Pham, Olawale A R Sulaiman, Roger Smith, Cuong J Bui
BACKGROUND: Spinal cord transection is a radical but effective treatment for highly selective cases of symptomatic spinal retethering in paraplegic spina bifida patients. Autonomic dysreflexia (AD) is a potentially life-threatening syndrome involving a dysregulated sympathetic discharge reflex commonly seen following cervical and high thoracic spinal cord injury, leading to a disconnect between autonomic pathways above and below the lesion that can lead to severe complications including uncontrolled hypertension, bradycardia, stroke, and potentially death...
August 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28782353/a-self-powered-wearable-noninvasive-electronic-skin-for-perspiration-analysis-based-on-piezo-biosensing-unit-matrix-of-enzyme-zno-nanoarrays
#15
Wuxiao Han, Haoxuan He, Linlin Zhang, Chuanyi Dong, Hui Zeng, Yitong Dai, Lili Xing, Yan Zhang, Xinyu Xue
The emerging multifunctional flexible electronic-skin for establishing body-electric interaction can enable real-time monitoring of personal health status as a new personalized medicine technique. A key difficulty in the device design is the flexible power supply. Here a self-powered wearable noninvasive electronic-skin for perspiration analysis has been realized on the basis of a piezo-biosensing unit matrix of enzyme/ZnO nanoarrays. The electronic-skin can detect lactate, glucose, uric acid, and urea in the perspiration, and no outside electrical power supply or battery is used in the biosensing process...
August 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28748727/silk-fabric-dyed-with-extract-of-sophora-flower-bud
#16
Su Yan, Shanshan Pan, Junling Ji
This study analysed the use of sophora flower bud extract for dyeing and the resulting colour character and fastness of dyed silk fabric. The pigment composition on the silk fabric and recycling of this extract were also studied. The results indicated that the dyed silk fabric possessed good washing, rubbing and perspiration fastness, and the pigment composition on the silk fabric was mainly rutin and quercetin. The average recovery rate of the dye was 55.00%. These results demonstrate that the sophora flower bud extract is an effective natural dye...
July 27, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28724276/fatal-small-intestinal-ischemia-due-to-methamphetamine-intoxication-report-of-a-case-with-autopsy-results
#17
Hamid Attaran
Methamphetamine is one of the most common abused drugs, so its various effects on different body organs should be familiar to all physicians. Regarding its gastrointestinal sequels, there are few reports of ischemic colitis induced by its vasoconstrictive effects. This is the first report of isolated small intestinal infarction resulting in death following methamphetamine toxicity. A 40-year-old woman with a past history of medical treatment for obesity referred to hospital with severe chest and back pain, perspiration, nausea, agitation, high blood pressure, bradycardia and subsequent lethargy and vasomotor instability...
May 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28706557/comparative-pharmacokinetics-and-bioavailability-of-three-ephedrines-in-rat-after-oral-administration-of-unprocessed-and-honey-fried-ephedra-extract-by-response-surface-experimental-design
#18
Yezhe Cheng, Yu Zhang, Hang Xing, Kun Qian, Longshan Zhao, Xiaohui Chen
Ephedra have been used as a common traditional Chinese medicine for thousands of years. However, the perspiration effect of the unprocessed ephedra was too strong. Clinical trials have shown that processing methods play a critical role in moderating the perspiration property of ephedra according to the needs. A LC-MS/MS method was developed and validated to compare the pharmacokinetic properties of the three ephedrines after oral administration of unprocessed and honey-fried ephedra extract. The contents of honey, frying temperature, and frying time were set at 20%, 116°C, and 7 min by the Box-Behnken response surface method, respectively...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28675233/integrated-sudomotor-axon-reflex-sweat-stimulation-for-continuous-sweat-analyte-analysis-with-individuals-at-rest
#19
Zachary Sonner, Eliza Wilder, Trudy Gaillard, Gerald Kasting, Jason Heikenfeld
Eccrine sweat has rapidly emerged as a non-invasive, ergonomic, and rich source of chemical analytes with numerous technological demonstrations now showing the ability for continuous electrochemical sensing. However, beyond active perspirers (athletes, workers, etc.), continuous sweat access in individuals at rest has hindered the advancement of both sweat sensing science and technology. Reported here is integration of sudomotor axon reflex sweat stimulation for continuous wearable sweat analyte analysis, including the ability for side-by-side integration of chemical stimulants & sensors without cross-contamination...
July 25, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28667529/unbiased-race-based-massive-parallel-surveys-of-human-iga-antibody-repertoires
#20
Hanane El Bannoudi, Céline Anquetil, Marc J Braunstein, Sergei L Kosakovsky Pond, Gregg J Silverman
For investigations of human B-cell receptor (BCR) repertoires, we have developed a protocol for large-scale surveys of human antibody heavy chain (VH) rearrangements. Here we study IgA repertoires, as more IgA antibodies are synthesized in the human body on a daily level than all other isotypes combined. In fact, IgA is secreted at all mucosal surfaces, and it is also secreted in the perspiration that coats our cutaneous surfaces. In these studies we can characterize the IgA clonal diversity of B-cell populations obtained from any donor...
2017: Methods in Molecular Biology
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