Ekta Tiwari, Danielle S Porreca, Alan S Braverman, Lewis Holt-Bright, Nagat A Frara, Justin M Brown, Benjamin R Johnston, Stanley F Bazarek, Brendan A Hilliard, Michael Mazzei, Michel A Pontari, Daohai Yu, Michael R Ruggieri, Mary F Barbe
In pilot work we showed that somatic nerve transfers can restore motor function in long-term decentralized dogs. We continue to explore the effectiveness of motor reinnervation in 30 female dogs. After anesthesia, 12 underwent bilateral transection of coccygeal and sacral (S) spinal roots, dorsal roots of lumbar (L)7, and hypogastric nerves. Twelve months post-decentralization, 8 underwent transfer of obturator nerve branches to pelvic nerve vesical branches, and sciatic nerve branches to pudendal nerves, followed by 10 months recovery (ObNT-ScNT Reinn)...
March 18, 2024: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology