Stefanie Malan-Muller, Mireia Valles-Colomer, Christine L Foxx, Sara Vieira-Silva, Leigh L van den Heuvel, Jeroen Raes, Soraya Seedat, Christopher A Lowry, Sian M J Hemmings
Posttraumatic stress disorder (PTSD) imposes a significant burden on patients and communities. Although the microbiome-gut-brain axis has been proposed as a mediator or moderator of PTSD risk and persistence of symptoms, clinical data directly delineating the gut microbiome's relationship to PTSD are sparse. This study investigated associations between the gut microbiome and mental health outcomes in participants with PTSD (n = 79) and trauma-exposed controls (TECs) (n = 58). Diagnoses of PTSD, major depressive disorder (MDD), and childhood trauma were made using the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5), MINI International Neuropsychiatric Interview (MINI), and Childhood Trauma Questionnaire (CTQ), respectively...
March 2022: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology